BATF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.20246412
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.20246412
3cellular response to type I interferon (GO:0071357)5.97334206
4type I interferon signaling pathway (GO:0060337)5.97334206
5response to type I interferon (GO:0034340)5.93310129
6positive regulation of interferon-alpha production (GO:0032727)5.77970568
7positive regulation by symbiont of host defense response (GO:0052509)5.69090702
8modulation by symbiont of host defense response (GO:0052031)5.69090702
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.69090702
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.69090702
11positive regulation by organism of defense response of other organism involved in symbiotic interact5.69090702
12modulation by symbiont of host immune response (GO:0052553)5.69090702
13antigen processing and presentation of endogenous antigen (GO:0019883)5.56894014
14regulation of interferon-alpha production (GO:0032647)5.53786455
15response to interferon-alpha (GO:0035455)5.31551552
16negative regulation of viral genome replication (GO:0045071)5.05484589
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.90980105
18regulation of interferon-beta biosynthetic process (GO:0045357)4.89759019
19immunoglobulin mediated immune response (GO:0016064)4.62565208
20negative regulation of interleukin-12 production (GO:0032695)4.60488914
21response to interferon-beta (GO:0035456)4.57134078
22positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.56437875
23response to peptidoglycan (GO:0032494)4.45946465
24lipopolysaccharide-mediated signaling pathway (GO:0031663)4.26479788
25positive regulation of chemokine biosynthetic process (GO:0045080)4.26165032
26neutrophil activation involved in immune response (GO:0002283)4.22265941
27positive regulation of type 2 immune response (GO:0002830)4.16916993
28interferon-gamma-mediated signaling pathway (GO:0060333)4.13567660
29positive regulation of interferon-beta production (GO:0032728)4.11146017
30macrophage activation involved in immune response (GO:0002281)4.08318633
31regulation of vitamin D biosynthetic process (GO:0060556)4.07379869
32response to host immune response (GO:0052572)4.03294032
33response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.03294032
34lymphocyte chemotaxis (GO:0048247)4.01919722
35regulation of T-helper 1 cell differentiation (GO:0045625)3.98791712
36cellular response to exogenous dsRNA (GO:0071360)3.96071796
37cellular response to interferon-beta (GO:0035458)3.87397657
38T-helper 1 type immune response (GO:0042088)3.81249058
39negative regulation of cell killing (GO:0031342)3.81039168
40negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.81039168
41regulation of cytokine secretion involved in immune response (GO:0002739)3.75210007
42cellular response to interferon-alpha (GO:0035457)3.73323316
43positive regulation of antigen processing and presentation (GO:0002579)3.65736462
44response to host (GO:0075136)3.62638849
45response to host defenses (GO:0052200)3.62638849
46response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.62638849
47negative regulation of cytokine production involved in immune response (GO:0002719)3.62182725
48production of molecular mediator involved in inflammatory response (GO:0002532)3.59990730
49natural killer cell mediated cytotoxicity (GO:0042267)3.59944210
50natural killer cell mediated immunity (GO:0002228)3.59944210
51detection of molecule of bacterial origin (GO:0032490)3.58480423
52positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.57620301
53detection of other organism (GO:0098543)3.57078524
54regulation of chemokine biosynthetic process (GO:0045073)3.53397750
55regulation of vitamin metabolic process (GO:0030656)3.52983116
56positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.52765490
57cellular response to interferon-gamma (GO:0071346)3.49899417
58germinal center formation (GO:0002467)3.47824884
59B cell mediated immunity (GO:0019724)3.47355507
60regulation of type I interferon-mediated signaling pathway (GO:0060338)3.46849296
61positive regulation of heat generation (GO:0031652)3.46594168
62T cell migration (GO:0072678)3.46577047
63positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.45375180
64positive regulation of cAMP-mediated signaling (GO:0043950)3.43268673
65response to muramyl dipeptide (GO:0032495)3.41262764
66regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.41040397
67respiratory burst (GO:0045730)3.41022589
68cellular response to virus (GO:0098586)3.39897958
69positive regulation of toll-like receptor signaling pathway (GO:0034123)3.39845104
70regulation of podosome assembly (GO:0071801)3.39262251
71detection of bacterium (GO:0016045)3.39111459
72regulation of RIG-I signaling pathway (GO:0039535)3.36119129
73defense response to virus (GO:0051607)3.35307078
74positive regulation of natural killer cell differentiation (GO:0032825)3.35136641
75regulation of fever generation (GO:0031620)3.34210901
76regulation of type 2 immune response (GO:0002828)3.33488147
77regulation of T cell tolerance induction (GO:0002664)3.32314302
78negative regulation of myeloid cell apoptotic process (GO:0033033)3.28941302
79interferon-gamma secretion (GO:0072643)3.28167212
80response to interferon-gamma (GO:0034341)3.27730516
81detection of external biotic stimulus (GO:0098581)3.26769307
82regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.25380056
83granulocyte activation (GO:0036230)3.23329033
84regulation of mononuclear cell migration (GO:0071675)3.21835039
85NIK/NF-kappaB signaling (GO:0038061)3.21189620
86branching involved in labyrinthine layer morphogenesis (GO:0060670)3.16323000
87myeloid cell activation involved in immune response (GO:0002275)3.15029704
88regulation of antigen processing and presentation (GO:0002577)3.14853362
89regulation of interferon-beta production (GO:0032648)3.14628771
90positive regulation of interleukin-12 production (GO:0032735)3.14091311
91positive regulation of T cell cytokine production (GO:0002726)3.10531113
92negative regulation of viral process (GO:0048525)3.08794117
93regulation of T-helper 2 cell differentiation (GO:0045628)3.07895279
94microglial cell activation (GO:0001774)3.07622392
95eosinophil chemotaxis (GO:0048245)3.07110535
96regulation of interleukin-12 production (GO:0032655)3.04449694
97monocyte chemotaxis (GO:0002548)3.03531538
98regulation of chronic inflammatory response (GO:0002676)3.03432779
99regulation of interleukin-8 biosynthetic process (GO:0045414)3.03082828
100hydrogen peroxide biosynthetic process (GO:0050665)3.00066779
101* myeloid dendritic cell differentiation (GO:0043011)2.98911191
102regulation of dendritic cell antigen processing and presentation (GO:0002604)2.96148337
103negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.94974529
104neutrophil activation (GO:0042119)2.94314117
105positive regulation of acute inflammatory response (GO:0002675)2.93235346
106positive regulation of gamma-delta T cell activation (GO:0046645)2.92916368
107regulation of viral genome replication (GO:0045069)2.92805655
108positive regulation of lymphocyte migration (GO:2000403)2.91389793
109regulation of interleukin-12 biosynthetic process (GO:0045075)2.90490317
110response to exogenous dsRNA (GO:0043330)2.90092260
111regulation of tolerance induction (GO:0002643)2.88790406
112negative regulation of production of molecular mediator of immune response (GO:0002701)2.88718247
113positive regulation of Cdc42 GTPase activity (GO:0043089)2.88506158
114positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.88358637
115regulation of toll-like receptor signaling pathway (GO:0034121)2.88054883
116positive regulation of NF-kappaB import into nucleus (GO:0042346)2.88001603
117* response to protozoan (GO:0001562)2.87457748
118positive regulation of interleukin-17 production (GO:0032740)2.86308206
119regulation of interferon-gamma biosynthetic process (GO:0045072)2.84910573
120antigen processing and presentation via MHC class Ib (GO:0002475)2.84910109
121detection of biotic stimulus (GO:0009595)2.84904523
122regulation of interleukin-17 production (GO:0032660)2.82797784
123macrophage activation (GO:0042116)2.82626518
124positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.81344126
125regulation of T-helper cell differentiation (GO:0045622)2.80713710
126positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.80371596
127regulation of membrane protein ectodomain proteolysis (GO:0051043)2.78141955
128positive regulation of interleukin-6 production (GO:0032755)2.76479671
129regulation of regulatory T cell differentiation (GO:0045589)2.75834026
130regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.73375070
131positive regulation of chemokine production (GO:0032722)2.72397904
132positive regulation of tolerance induction (GO:0002645)2.72122319
133* defense response to protozoan (GO:0042832)2.71913767
134JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.71194690
135eosinophil migration (GO:0072677)2.68739246
136cellular response to lipopolysaccharide (GO:0071222)2.68062347
137regulation of cholesterol storage (GO:0010885)2.67340388

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.47382996
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.95782847
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human6.56204306
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.74000498
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.66386448
6* IRF8_27001747_Chip-Seq_BMDM_Mouse4.17923513
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.45128733
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.36523971
9RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.00546991
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.77326662
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.75656121
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.69394261
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.59702153
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.59356667
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.57120629
16GATA1_22025678_ChIP-Seq_K562_Human2.53680642
17STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.47570285
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.35563076
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.30086156
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.27751509
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.13037931
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.07785378
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.06229521
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.03946516
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.75487462
26SPI1_23547873_ChIP-Seq_NB4_Human1.72457808
27SCL_19346495_ChIP-Seq_HPC-7_Human1.71836683
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.71594928
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.70890538
30VDR_24763502_ChIP-Seq_THP-1_Human1.61358013
31SPI1_23127762_ChIP-Seq_K562_Human1.55412862
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.55274713
33GATA2_21666600_ChIP-Seq_HMVEC_Human1.48390661
34* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.48043529
35PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.47805705
36MAF_26560356_Chip-Seq_TH1_Human1.47064520
37* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46649453
38PU_27001747_Chip-Seq_BMDM_Mouse1.38468931
39SOX2_20726797_ChIP-Seq_SW620_Human1.38285240
40MYB_26560356_Chip-Seq_TH2_Human1.36552904
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.34301101
42VDR_21846776_ChIP-Seq_THP-1_Human1.30588165
43CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.29405612
44EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24506391
45EGR1_19032775_ChIP-ChIP_M12_Human1.24418955
46KDM2B_26808549_Chip-Seq_DND41_Human1.23983963
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23444970
48GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22739687
49RACK7_27058665_Chip-Seq_MCF-7_Human1.21120608
50PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20010351
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18345976
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18185525
53VDR_24787735_ChIP-Seq_THP-1_Human1.17468322
54* ELK3_25401928_ChIP-Seq_HUVEC_Human1.15904518
55FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.14324770
56RUNX_20019798_ChIP-Seq_JUKART_Human1.14169272
57CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14056376
58PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.13729498
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13301072
60PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12888423
61* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12768146
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11226709
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11141784
64MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10568563
65ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.10279487
66GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09599437
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09502814
68MYB_26560356_Chip-Seq_TH1_Human1.09292716
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.08036776
70CDX2_20551321_ChIP-Seq_CACO-2_Human1.08005931
71FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.07321469
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07231069
73TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06245964
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06049320
75TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05618682
76GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04339079
77E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.02145449
78PPARA_22158963_ChIP-Seq_LIVER_Mouse1.00354307
79TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98092694
80MYC_22102868_ChIP-Seq_BL_Human0.97583930
81GATA1_19941827_ChIP-Seq_MEL_Mouse0.95975364
82VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95672473
83SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95099488
84ESR1_21235772_ChIP-Seq_MCF-7_Human0.94752541
85PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92083574
86GATA3_26560356_Chip-Seq_TH2_Human0.91476743
87CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91105646
88UTX_26944678_Chip-Seq_JUKART_Human0.91097111
89KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91040317
90GATA1_19941826_ChIP-Seq_K562_Human0.90574349
91NCOR1_26117541_ChIP-Seq_K562_Human0.88955850
92TCF7_22412390_ChIP-Seq_EML_Mouse0.88535226
93RXR_22158963_ChIP-Seq_LIVER_Mouse0.87761718
94MAF_26560356_Chip-Seq_TH2_Human0.86567556
95KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.85363684
96GATA3_27048872_Chip-Seq_THYMUS_Human0.85207813
97ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.85038385
98SRY_22984422_ChIP-ChIP_TESTIS_Rat0.83773423
99TRIM28_21343339_ChIP-Seq_HEK293_Human0.81245273
100MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.79852609
101SOX2_27498859_Chip-Seq_STOMACH_Mouse0.78839070
102GATA2_19941826_ChIP-Seq_K562_Human0.78491043
103LXR_22158963_ChIP-Seq_LIVER_Mouse0.77513724
104LXR_22292898_ChIP-Seq_THP-1_Human0.75916537
105NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.74504260
106RARG_19884340_ChIP-ChIP_MEFs_Mouse0.74233974
107* GATA4_25053715_ChIP-Seq_YYC3_Human0.72187708
108TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.71984599
109KDM2B_26808549_Chip-Seq_SUP-B15_Human0.71961925
110BCOR_27268052_Chip-Seq_Bcells_Human0.70104015
111STAT1_20625510_ChIP-Seq_HELA_Human0.70067919
112* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.69867418
113CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.68931033
114SMAD_19615063_ChIP-ChIP_OVARY_Human0.67513206
115BCL6_27268052_Chip-Seq_Bcells_Human0.67084933

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.35862717
2MP0009785_altered_susceptibility_to4.13559172
3MP0003724_increased_susceptibility_to3.64553022
4MP0006082_CNS_inflammation3.62494016
5MP0003436_decreased_susceptibility_to3.36709450
6MP0003303_peritoneal_inflammation3.36606715
7MP0002148_abnormal_hypersensitivity_rea3.35038657
8MP0005025_abnormal_response_to3.09791331
9MP0005058_abnormal_lysosome_morphology3.09041739
10MP0004510_myositis2.99584500
11MP0005000_abnormal_immune_tolerance2.90597678
12MP0001790_abnormal_immune_system2.89418148
13MP0005387_immune_system_phenotype2.89418148
14MP0002419_abnormal_innate_immunity2.77924114
15MP0000685_abnormal_immune_system2.58440292
16MP0005451_abnormal_body_composition2.49725911
17MP0005671_abnormal_response_to2.49637012
18MP0002452_abnormal_antigen_presenting2.38294492
19MP0009840_abnormal_foam_cell2.34493950
20MP0001800_abnormal_humoral_immune2.32938550
21MP0002723_abnormal_immune_serum2.31932121
22MP0004947_skin_inflammation2.30644043
23MP0010155_abnormal_intestine_physiology2.27323135
24MP0001533_abnormal_skeleton_physiology2.22096982
25MP0002139_abnormal_hepatobiliary_system2.07847868
26MP0003191_abnormal_cellular_cholesterol2.04183501
27MP0003300_gastrointestinal_ulcer2.03226006
28MP0001819_abnormal_immune_cell2.00741306
29MP0005464_abnormal_platelet_physiology1.94809867
30MP0002420_abnormal_adaptive_immunity1.93618588
31MP0008004_abnormal_stomach_pH1.88128621
32MP0004858_abnormal_nervous_system1.87326412
33MP0009764_decreased_sensitivity_to1.81237181
34MP0001845_abnormal_inflammatory_respons1.80290709
35MP0003075_altered_response_to1.79646433
36MP0008469_abnormal_protein_level1.79134222
37MP0005167_abnormal_blood-brain_barrier1.72208254
38MP0001853_heart_inflammation1.66459016
39MP0000343_altered_response_to1.64386669
40MP0009333_abnormal_splenocyte_physiolog1.57585135
41MP0003448_altered_tumor_morphology1.57181334
42MP0000604_amyloidosis1.55532334
43MP0003806_abnormal_nucleotide_metabolis1.49987533
44MP0003172_abnormal_lysosome_physiology1.46635158
45MP0005310_abnormal_salivary_gland1.45928619
46MP0005257_abnormal_intraocular_pressure1.44623257
47MP0002006_tumorigenesis1.42346656
48MP0000716_abnormal_immune_system1.42204511
49MP0002405_respiratory_system_inflammati1.41591835
50MP0005083_abnormal_biliary_tract1.39058842
51MP0004782_abnormal_surfactant_physiolog1.37254511
52MP0002166_altered_tumor_susceptibility1.35792905
53MP0002398_abnormal_bone_marrow1.31110016
54MP0005166_decreased_susceptibility_to1.29328059
55MP0009278_abnormal_bone_marrow1.29144328
56MP0001873_stomach_inflammation1.28123175
57MP0010307_abnormal_tumor_latency1.25416761
58MP0002998_abnormal_bone_remodeling1.23845693
59MP0002254_reproductive_system_inflammat1.22876121
60MP0005164_abnormal_response_to1.20056656
61MP0001663_abnormal_digestive_system1.17349991
62MP0002429_abnormal_blood_cell1.15535242
63MP0002277_abnormal_respiratory_mucosa1.12416719
64MP0000490_abnormal_crypts_of1.11240707
65MP0006054_spinal_hemorrhage1.09681689
66MP0005397_hematopoietic_system_phenotyp1.09297051
67MP0001545_abnormal_hematopoietic_system1.09297051
68MP0003866_abnormal_defecation1.06681598
69MP0003690_abnormal_glial_cell1.04749320
70MP0000689_abnormal_spleen_morphology1.03776514
71MP0005360_urolithiasis1.01667171
72MP0003195_calcinosis1.01458046
73MP0004883_abnormal_blood_vessel0.99276036
74MP0002722_abnormal_immune_system0.98359362
75MP0009763_increased_sensitivity_to0.95031688
76MP0000858_altered_metastatic_potential0.93406575
77MP0001851_eye_inflammation0.90643445
78MP0003186_abnormal_redox_activity0.89928354
79MP0005390_skeleton_phenotype0.89924378
80MP0001501_abnormal_sleep_pattern0.80694433
81MP0000249_abnormal_blood_vessel0.80269571
82MP0001542_abnormal_bone_strength0.79940958
83MP0005319_abnormal_enzyme/_coenzyme0.79143631
84MP0003763_abnormal_thymus_physiology0.78684782
85MP0005174_abnormal_tail_pigmentation0.77944213
86MP0003828_pulmonary_edema0.76528356
87MP0005023_abnormal_wound_healing0.76394240
88MP0008874_decreased_physiological_sensi0.76122308
89MP0003183_abnormal_peptide_metabolism0.76013764
90MP0003453_abnormal_keratinocyte_physiol0.74731246
91MP0010352_gastrointestinal_tract_polyps0.72719148
92MP0005076_abnormal_cell_differentiation0.71330350
93MP0005165_increased_susceptibility_to0.70767868
94MP0002933_joint_inflammation0.70357503
95MP0005381_digestive/alimentary_phenotyp0.69392211
96MP0000465_gastrointestinal_hemorrhage0.68979572
97MP0005584_abnormal_enzyme/coenzyme_acti0.68793757
98MP0003656_abnormal_erythrocyte_physiolo0.68390586
99MP0002136_abnormal_kidney_physiology0.68315097
100MP0002138_abnormal_hepatobiliary_system0.68186259
101MP0003646_muscle_fatigue0.67066413
102MP0005666_abnormal_adipose_tissue0.66704696
103MP0003566_abnormal_cell_adhesion0.64579508
104MP0001666_abnormal_nutrient_absorption0.64167508
105MP0003879_abnormal_hair_cell0.63707900
106MP0009643_abnormal_urine_homeostasis0.62285013
107MP0003045_fibrosis0.61722863
108MP0008873_increased_physiological_sensi0.61534827
109MP0002332_abnormal_exercise_endurance0.61463681
110MP0000609_abnormal_liver_physiology0.60618299
111MP0009765_abnormal_xenobiotic_induced0.58974316
112MP0008260_abnormal_autophagy0.56510274
113MP0003795_abnormal_bone_structure0.53411656
114MP0003091_abnormal_cell_migration0.51903258
115MP0003329_amyloid_beta_deposits0.51452758
116MP0001849_ear_inflammation0.51356750

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.92295251
2Eczematoid dermatitis (HP:0000976)5.56936458
3Elevated erythrocyte sedimentation rate (HP:0003565)5.46917546
4Recurrent bacterial skin infections (HP:0005406)5.46321785
5Chronic otitis media (HP:0000389)5.29160219
6Autoimmune thrombocytopenia (HP:0001973)4.99653788
7Abnormality of macrophages (HP:0004311)4.70913774
8Systemic lupus erythematosus (HP:0002725)4.70401041
9Orchitis (HP:0100796)4.57722481
10Myositis (HP:0100614)4.56819050
11Recurrent gram-negative bacterial infections (HP:0005420)4.52234583
12Vacuolated lymphocytes (HP:0001922)3.95055835
13Prostate neoplasm (HP:0100787)3.92762831
14Pustule (HP:0200039)3.86617138
15Increased cerebral lipofuscin (HP:0011813)3.86440627
16Abnormality of the nasal mucosa (HP:0000433)3.83589110
17Nasal polyposis (HP:0100582)3.78710892
18Mediastinal lymphadenopathy (HP:0100721)3.73692000
19Retrobulbar optic neuritis (HP:0100654)3.69116835
20Optic neuritis (HP:0100653)3.69116835
21Keratoconjunctivitis (HP:0001096)3.59100463
22Interstitial pulmonary disease (HP:0006530)3.54248369
23Recurrent skin infections (HP:0001581)3.41496053
24Vasculitis (HP:0002633)3.37762249
25Increased neuronal autofluorescent lipopigment (HP:0002074)3.35031278
26Recurrent fungal infections (HP:0002841)3.33219388
27Gingivitis (HP:0000230)3.30707447
28Axonal loss (HP:0003447)3.30131973
29Basal ganglia calcification (HP:0002135)3.28109383
30Recurrent viral infections (HP:0004429)3.27866815
31Tetraparesis (HP:0002273)3.24905664
32Petechiae (HP:0000967)3.12182742
33Gastrointestinal infarctions (HP:0005244)2.98474764
34Increased IgM level (HP:0003496)2.95742211
35Premature loss of primary teeth (HP:0006323)2.93039707
36Periodontitis (HP:0000704)2.90806004
37Stomatitis (HP:0010280)2.87158054
38Loss of speech (HP:0002371)2.84474326
39Gangrene (HP:0100758)2.80462826
40Malnutrition (HP:0004395)2.76595356
41Hypergammaglobulinemia (HP:0010702)2.76347986
42Dysostosis multiplex (HP:0000943)2.74381076
43Encephalitis (HP:0002383)2.70836243
44Cellulitis (HP:0100658)2.68995529
45Glomerulonephritis (HP:0000099)2.67002218
46Progressive neurologic deterioration (HP:0002344)2.61260739
47Recurrent bronchitis (HP:0002837)2.58125734
48Chronic sinusitis (HP:0011109)2.57561182
49Autoimmune hemolytic anemia (HP:0001890)2.49580732
50Urticaria (HP:0001025)2.49529853
51Pulmonary infiltrates (HP:0002113)2.48224783
52Hepatosplenomegaly (HP:0001433)2.46423270
53Obstructive lung disease (HP:0006536)2.45934039
54Chronic obstructive pulmonary disease (HP:0006510)2.45934039
55Increased IgE level (HP:0003212)2.44279110
56Leukocytosis (HP:0001974)2.40900030
57Hematochezia (HP:0002573)2.40802800
58Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.40517840
59Increased serum ferritin (HP:0003281)2.36991027
60Abnormality of glycolipid metabolism (HP:0010969)2.36003122
61Abnormality of liposaccharide metabolism (HP:0010968)2.36003122
62Abnormality of glycosphingolipid metabolism (HP:0004343)2.36003122
63Mucopolysacchariduria (HP:0008155)2.35299847
64Urinary glycosaminoglycan excretion (HP:0003541)2.35299847
65Abnormality of the prostate (HP:0008775)2.34936979
66Abnormality of the pleura (HP:0002103)2.34272473
67Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.34206056
68Nausea (HP:0002018)2.34012249
69Disinhibition (HP:0000734)2.32607779
70Pulmonary embolism (HP:0002204)2.32604477
71Complement deficiency (HP:0004431)2.32033661
72Bone pain (HP:0002653)2.31805774
73Porencephaly (HP:0002132)2.29523054
74Nephritis (HP:0000123)2.26466425
75Recurrent cutaneous fungal infections (HP:0011370)2.26258862
76Chronic mucocutaneous candidiasis (HP:0002728)2.26258862
77Colitis (HP:0002583)2.26186784
78Episodic fever (HP:0001954)2.25727308
79Nuclear cataract (HP:0100018)2.24737651
80Gingival bleeding (HP:0000225)2.24692859
81Inflammation of the large intestine (HP:0002037)2.23952925
82Purpura (HP:0000979)2.23277589
83Acne (HP:0001061)2.22473619
84Abnormal delayed hypersensitivity skin test (HP:0002963)2.21585699
85Arterial thrombosis (HP:0004420)2.20836068
86Esophageal neoplasm (HP:0100751)2.20118385
87Neoplasm of head and neck (HP:0012288)2.20118385
88Osteomyelitis (HP:0002754)2.18380927
89Abnormality of complement system (HP:0005339)2.17258027
90Spontaneous hematomas (HP:0007420)2.17091515
91Polyneuropathy (HP:0001271)2.16380875
92Abnormality of polysaccharide metabolism (HP:0011012)2.15934719
93Abnormality of glycosaminoglycan metabolism (HP:0004371)2.15934719
94Abnormality of mucopolysaccharide metabolism (HP:0011020)2.15934719
95Thick nail (HP:0001805)2.15708353
96Joint swelling (HP:0001386)2.15426908
97Hemoptysis (HP:0002105)2.15042372
98Poor head control (HP:0002421)2.14060484
99Mutism (HP:0002300)2.13606084
100Peritonitis (HP:0002586)2.12020803
101Parakeratosis (HP:0001036)2.10829260
102Abnormality of T cell physiology (HP:0011840)2.10800695
103Keratoconjunctivitis sicca (HP:0001097)2.09401264
104Gastrointestinal inflammation (HP:0004386)2.09207520
105Anorexia (HP:0002039)2.07873308
106Progressive visual loss (HP:0000529)2.06883861
107Vertigo (HP:0002321)2.06616987
108Abnormality of T cell number (HP:0011839)2.05547471
109Abnormality of the endocardium (HP:0004306)2.03867136
110Neurofibrillary tangles (HP:0002185)2.03331867
111Abnormality of iron homeostasis (HP:0011031)2.02321079
112T lymphocytopenia (HP:0005403)2.01064936
113Recurrent pneumonia (HP:0006532)2.00261007
114Meningitis (HP:0001287)1.99926606
115Osteolytic defects of the hand bones (HP:0009699)1.99174275
116Osteolytic defects of the phalanges of the hand (HP:0009771)1.99174275
117Amyloidosis (HP:0011034)1.98488913
118Abnormality of the pericardium (HP:0001697)1.97647701
119Hydroxyprolinuria (HP:0003080)1.96502574
120Abnormality of proline metabolism (HP:0010907)1.96502574
121Glomerulopathy (HP:0100820)1.95470571
122Cheilitis (HP:0100825)1.95121904
123Recurrent lower respiratory tract infections (HP:0002783)1.95080015
124Hemorrhage of the eye (HP:0011885)1.94953904
125Myocardial infarction (HP:0001658)1.90362368
126Keratitis (HP:0000491)1.89341003
127Polygenic inheritance (HP:0010982)1.89038474
128Polycythemia (HP:0001901)1.88608352
129Apathy (HP:0000741)1.88149066

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TBK13.98286531
2MST1R3.83981575
3ERN13.81666990
4TYK23.56250649
5BLK3.33858423
6IKBKE3.30364296
7MAP3K143.04209492
8MAP4K12.86391192
9KIT2.86329198
10PBK2.70371343
11RIPK42.43514195
12TAOK22.41154819
13IRAK42.32703665
14PIM22.30059683
15JAK32.29974987
16PRPF4B2.21926835
17MATK2.13916868
18JAK12.04666178
19EPHB11.95077963
20PIK3CA1.89666149
21TXK1.76839450
22IKBKB1.76357192
23FGFR41.75113552
24CSK1.60724494
25IRAK31.59217635
26CDC42BPA1.58599600
27FGR1.50701142
28KSR21.48352886
29TAOK31.41806967
30MAP3K131.36695792
31ZAP701.33797413
32EPHA31.31117466
33CSF1R1.29399057
34SYK1.22092109
35MST41.19644655
36NME21.18824867
37KDR1.16125314
38HCK1.15061923
39LYN1.12813004
40BMX1.11934567
41MAP3K11.09368390
42TRIB31.08717945
43MAP3K21.06784425
44BTK1.06207451
45MAP2K21.03528694
46JAK21.01086175
47TGFBR21.00949799
48FES0.98926166
49PRKG20.93660816
50MET0.92679178
51LCK0.91713224
52PTK60.91310887
53FGFR30.90449574
54DDR20.85044243
55RPS6KA40.84979520
56CHUK0.84836767
57IRAK10.84748776
58TNK20.83199900
59MAP3K110.82559281
60MAP3K50.79669406
61ABL20.76955226
62TESK20.76625916
63MAP2K30.75408475
64ARAF0.73499694
65ADRBK20.71959861
66TEC0.71800520
67SIK30.69638014
68PIM10.69555272
69SIK10.69138576
70TIE10.66852687
71HIPK20.66644740
72MAP2K60.66427916
73RIPK10.65851528
74TGFBR10.65132007
75TLK10.63984398
76PRKD20.62446718
77CLK10.62050748
78MAPK70.58224214
79TESK10.56622667
80ACVR1B0.55462672
81PRKCD0.54379891
82DAPK30.54322923
83PDPK10.53695919
84EGFR0.52549662
85MARK20.52236554
86DYRK1B0.50139730
87STK100.49505829
88PDK10.48825771
89MARK30.48723305
90MAP3K30.47526615
91EIF2AK20.47437725
92NUAK10.44386914
93ABL10.44153536
94DYRK30.42955218
95BMPR20.42669792
96MUSK0.42429284
97LRRK20.39792330
98MAP3K60.38844265
99MAP3K120.38188429
100MAP2K10.37450691
101IRAK20.36566881
102FYN0.35035667
103NEK90.34331948
104MAP3K80.31480163
105YES10.31461013
106MAPK110.30710899
107RPS6KL10.28733495
108RPS6KC10.28733495
109PIK3CG0.28698654
110MAPKAPK20.28448207
111TRPM70.28296680
112PKN10.28013925
113PAK40.27639067
114STK240.26760593
115CAMK1D0.26390465
116MOS0.26335731
117EPHA20.25520870
118TAOK10.24446822
119GRK60.24388932
120DAPK20.24099421
121ICK0.23120627
122IGF1R0.23064848
123SRC0.22631906
124TTN0.22361906
125RET0.21466464
126CDK60.20286815
127STK40.20228126
128MAP3K100.20168212
129GRK70.19804035
130MAPK40.16825840
131ALK0.16472504

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.31798744
2Toll-like receptor signaling pathway_Homo sapiens_hsa046203.10207800
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.87479443
4Staphylococcus aureus infection_Homo sapiens_hsa051502.85123784
5RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.84555951
6Pertussis_Homo sapiens_hsa051332.58514502
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.44967046
8Influenza A_Homo sapiens_hsa051642.31897097
9NOD-like receptor signaling pathway_Homo sapiens_hsa046212.23304724
10Malaria_Homo sapiens_hsa051442.22229764
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.21109848
12Osteoclast differentiation_Homo sapiens_hsa043802.14084962
13Graft-versus-host disease_Homo sapiens_hsa053322.13327709
14African trypanosomiasis_Homo sapiens_hsa051432.12131360
15Legionellosis_Homo sapiens_hsa051342.11180549
16Allograft rejection_Homo sapiens_hsa053302.10892447
17Tuberculosis_Homo sapiens_hsa051522.05082500
18Measles_Homo sapiens_hsa051621.98624463
19TNF signaling pathway_Homo sapiens_hsa046681.91492914
20Asthma_Homo sapiens_hsa053101.89496856
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.88566800
22Salmonella infection_Homo sapiens_hsa051321.82500029
23Mineral absorption_Homo sapiens_hsa049781.76786459
24Herpes simplex infection_Homo sapiens_hsa051681.74356648
25Rheumatoid arthritis_Homo sapiens_hsa053231.71001730
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.67580045
27Toxoplasmosis_Homo sapiens_hsa051451.66407822
28Hepatitis C_Homo sapiens_hsa051601.64589911
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.61156555
30Caffeine metabolism_Homo sapiens_hsa002321.57390421
31Shigellosis_Homo sapiens_hsa051311.54666350
32Lysosome_Homo sapiens_hsa041421.53497112
33Antigen processing and presentation_Homo sapiens_hsa046121.51491952
34B cell receptor signaling pathway_Homo sapiens_hsa046621.39526169
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.28508896
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.25100001
37Apoptosis_Homo sapiens_hsa042101.25040265
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.21526090
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.18598902
40Chemokine signaling pathway_Homo sapiens_hsa040621.18302850
41Phagosome_Homo sapiens_hsa041451.10810105
42Hematopoietic cell lineage_Homo sapiens_hsa046401.08840577
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07616815
44Type I diabetes mellitus_Homo sapiens_hsa049401.06855328
45Hepatitis B_Homo sapiens_hsa051611.05861700
46Other glycan degradation_Homo sapiens_hsa005111.01379643
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00263303
48Primary immunodeficiency_Homo sapiens_hsa053400.92928888
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91133277
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.85464437
51Amoebiasis_Homo sapiens_hsa051460.84556136
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84180856
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83071510
54Viral myocarditis_Homo sapiens_hsa054160.81784078
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81083226
56Prion diseases_Homo sapiens_hsa050200.79593250
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76942279
58Galactose metabolism_Homo sapiens_hsa000520.76121934
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72803021
60Prolactin signaling pathway_Homo sapiens_hsa049170.72205995
61Bladder cancer_Homo sapiens_hsa052190.69519079
62Epstein-Barr virus infection_Homo sapiens_hsa051690.68128326
63Folate biosynthesis_Homo sapiens_hsa007900.67065875
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66240030
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.65693285
66Autoimmune thyroid disease_Homo sapiens_hsa053200.65590129
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62155697
68Acute myeloid leukemia_Homo sapiens_hsa052210.58515808
69HIF-1 signaling pathway_Homo sapiens_hsa040660.57324388
70Complement and coagulation cascades_Homo sapiens_hsa046100.56489193
71Platelet activation_Homo sapiens_hsa046110.55657081
72Type II diabetes mellitus_Homo sapiens_hsa049300.55643012
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55146819
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54130257
75Arginine biosynthesis_Homo sapiens_hsa002200.53934065
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51765179
77Fat digestion and absorption_Homo sapiens_hsa049750.51219366
78Renin-angiotensin system_Homo sapiens_hsa046140.49920222
79ABC transporters_Homo sapiens_hsa020100.49078882
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43860265
81Sulfur metabolism_Homo sapiens_hsa009200.43565215
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42747965
83Insulin resistance_Homo sapiens_hsa049310.40070553
84T cell receptor signaling pathway_Homo sapiens_hsa046600.38676979
85HTLV-I infection_Homo sapiens_hsa051660.38484237
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38102292
87Sphingolipid metabolism_Homo sapiens_hsa006000.37818148
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37703825
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.37200281
90Fructose and mannose metabolism_Homo sapiens_hsa000510.37162601
91Chronic myeloid leukemia_Homo sapiens_hsa052200.36781383
92Pentose phosphate pathway_Homo sapiens_hsa000300.36266078
93VEGF signaling pathway_Homo sapiens_hsa043700.34544239
94Endocytosis_Homo sapiens_hsa041440.33314184
95Histidine metabolism_Homo sapiens_hsa003400.32777402
96Notch signaling pathway_Homo sapiens_hsa043300.29588702
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.29163237
98Starch and sucrose metabolism_Homo sapiens_hsa005000.26747623
99FoxO signaling pathway_Homo sapiens_hsa040680.26659535
100Pancreatic cancer_Homo sapiens_hsa052120.26228186
101Collecting duct acid secretion_Homo sapiens_hsa049660.25705907
102PPAR signaling pathway_Homo sapiens_hsa033200.24617663
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.24307314
104Dorso-ventral axis formation_Homo sapiens_hsa043200.21983757
105Renal cell carcinoma_Homo sapiens_hsa052110.20541893
106Viral carcinogenesis_Homo sapiens_hsa052030.19366267
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.18867840
108Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.18772330
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.18288533
110Sulfur relay system_Homo sapiens_hsa041220.18002259
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.15800167
112Vibrio cholerae infection_Homo sapiens_hsa051100.14792412
113Systemic lupus erythematosus_Homo sapiens_hsa053220.12388233
114Arachidonic acid metabolism_Homo sapiens_hsa005900.12031965
115GnRH signaling pathway_Homo sapiens_hsa049120.10994378
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.10981286

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