BAZ1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the bromodomain protein family. The bromodomain is a structural motif characteristic of proteins involved in chromatin-dependent regulation of transcription. This gene is deleted in Williams-Beuren syndrome, a developmental disorder caused by deletion of multiple genes at 7q11.23. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.57136202
2mitotic sister chromatid cohesion (GO:0007064)5.55379426
3nuclear pore organization (GO:0006999)5.07636007
4DNA unwinding involved in DNA replication (GO:0006268)4.59472742
5DNA strand elongation involved in DNA replication (GO:0006271)4.31007048
6protein localization to kinetochore (GO:0034501)4.29575074
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.27587526
8DNA replication initiation (GO:0006270)4.21478862
9mitotic chromosome condensation (GO:0007076)4.19782148
10DNA strand elongation (GO:0022616)4.18738249
11sister chromatid segregation (GO:0000819)4.14653825
12pre-miRNA processing (GO:0031054)4.13778790
13regulation of DNA endoreduplication (GO:0032875)4.13666496
14pore complex assembly (GO:0046931)4.12864852
15regulation of RNA export from nucleus (GO:0046831)3.99924513
16DNA replication checkpoint (GO:0000076)3.86356279
17negative regulation of histone methylation (GO:0031061)3.83626842
18DNA duplex unwinding (GO:0032508)3.75868238
19DNA geometric change (GO:0032392)3.75554503
20dosage compensation (GO:0007549)3.65977406
21regulation of histone H3-K9 methylation (GO:0051570)3.59423352
22protein localization to chromosome, centromeric region (GO:0071459)3.58360733
23cytoplasmic mRNA processing body assembly (GO:0033962)3.56793297
24telomere maintenance via semi-conservative replication (GO:0032201)3.56691334
25glucocorticoid receptor signaling pathway (GO:0042921)3.53755284
26mitotic sister chromatid segregation (GO:0000070)3.52528196
27heterochromatin organization (GO:0070828)3.49988490
28mRNA stabilization (GO:0048255)3.49643818
29RNA stabilization (GO:0043489)3.49643818
30peptidyl-lysine dimethylation (GO:0018027)3.48021699
31regulation of centrosome cycle (GO:0046605)3.45550647
32regulation of sister chromatid cohesion (GO:0007063)3.44884623
33positive regulation of histone deacetylation (GO:0031065)3.44767936
34chromatin assembly (GO:0031497)3.43492040
35regulation of mitotic spindle organization (GO:0060236)3.34592539
36DNA topological change (GO:0006265)3.31579008
37negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.30010004
38mitotic nuclear envelope disassembly (GO:0007077)3.27104764
39regulation of nucleobase-containing compound transport (GO:0032239)3.26091191
40regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.25843824
41positive regulation of mitotic sister chromatid separation (GO:1901970)3.25128941
42positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.25128941
43positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.25128941
44establishment of integrated proviral latency (GO:0075713)3.24885883
45kinetochore organization (GO:0051383)3.19148160
46regulation of histone H3-K27 methylation (GO:0061085)3.17896335
47translesion synthesis (GO:0019985)3.17806845
48regulation of centrosome duplication (GO:0010824)3.17062084
49telomere maintenance via recombination (GO:0000722)3.16553783
50mitotic recombination (GO:0006312)3.14699572
51formation of translation preinitiation complex (GO:0001731)3.13458588
52regulation of spindle organization (GO:0090224)3.10743120
53membrane disassembly (GO:0030397)3.10506893
54nuclear envelope disassembly (GO:0051081)3.10506893
55NLS-bearing protein import into nucleus (GO:0006607)3.10419889
56chromosome segregation (GO:0007059)3.04556083
57DNA conformation change (GO:0071103)3.03075907
58double-strand break repair via nonhomologous end joining (GO:0006303)3.02935416
59non-recombinational repair (GO:0000726)3.02935416
60establishment of chromosome localization (GO:0051303)3.00688259
61histone H3-K36 demethylation (GO:0070544)2.99558425
62corticosteroid receptor signaling pathway (GO:0031958)2.99387012
63positive regulation of DNA-dependent DNA replication (GO:2000105)2.96198184
64regulation of centriole replication (GO:0046599)2.95879329
65positive regulation of chromosome segregation (GO:0051984)2.95406663
66DNA synthesis involved in DNA repair (GO:0000731)2.93436046
67negative regulation of mRNA processing (GO:0050686)2.92402900
68negative regulation of RNA splicing (GO:0033119)2.91973862
69cellular protein complex localization (GO:0034629)2.91542804
70histone mRNA catabolic process (GO:0071044)2.91058136
71histone H3-K4 methylation (GO:0051568)2.90086053
72V(D)J recombination (GO:0033151)2.88776055
73protein complex localization (GO:0031503)2.88293929
74negative regulation of mRNA metabolic process (GO:1903312)2.84111583
75regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.84089747
76regulation of translational fidelity (GO:0006450)2.82787211
77histone H3-K4 trimethylation (GO:0080182)2.82781588
78protein export from nucleus (GO:0006611)2.82764435
79regulation of chromosome segregation (GO:0051983)2.82211052
80chromosome condensation (GO:0030261)2.81984335
81peptidyl-lysine trimethylation (GO:0018023)2.81686704
82DNA replication-dependent nucleosome assembly (GO:0006335)2.80994597
83DNA replication-dependent nucleosome organization (GO:0034723)2.80994597
84alternative mRNA splicing, via spliceosome (GO:0000380)2.80220714
85* chromatin assembly or disassembly (GO:0006333)2.78813737
86mRNA transport (GO:0051028)2.78375776
87regulation of mRNA stability (GO:0043488)2.77634418
88histone H3-K9 methylation (GO:0051567)2.75837814
89spindle organization (GO:0007051)2.75786394
90mitotic spindle organization (GO:0007052)2.74735105
91protein localization to chromosome (GO:0034502)2.74050142
92monoubiquitinated protein deubiquitination (GO:0035520)2.72673854
93histone H3-K9 demethylation (GO:0033169)2.71220862
94spindle assembly involved in mitosis (GO:0090307)2.71129647
95positive regulation of cell cycle checkpoint (GO:1901978)2.70452538
96histone lysine methylation (GO:0034968)2.70339003
97mRNA splice site selection (GO:0006376)2.70000237
98CENP-A containing nucleosome assembly (GO:0034080)2.68316401
99histone H2B ubiquitination (GO:0033523)2.68304913
100sister chromatid cohesion (GO:0007062)2.68188249
101mitotic cytokinesis (GO:0000281)2.66154228
102chromatin remodeling at centromere (GO:0031055)2.65124403
103regulation of double-strand break repair (GO:2000779)2.64851814
104response to UV-C (GO:0010225)2.64260242
105spindle assembly (GO:0051225)2.62398215
106regulation of histone H3-K4 methylation (GO:0051569)2.62329278
107negative regulation of DNA-dependent DNA replication (GO:2000104)2.62178583
108DNA replication-independent nucleosome organization (GO:0034724)2.61725366
109DNA replication-independent nucleosome assembly (GO:0006336)2.61725366
110histone H2A monoubiquitination (GO:0035518)2.60674058
111regulation of DNA-dependent DNA replication (GO:0090329)2.60267695
112meiotic chromosome segregation (GO:0045132)2.58783122
113DNA packaging (GO:0006323)2.58166631
114insulin-like growth factor receptor signaling pathway (GO:0048009)2.57012984
115protein-DNA complex disassembly (GO:0032986)2.56404862
116nucleosome disassembly (GO:0006337)2.56404862
117regulation of RNA stability (GO:0043487)2.55495022
118negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.55318959
119regulation of histone methylation (GO:0031060)2.54683762
120establishment of mitotic spindle localization (GO:0040001)2.54196374
121hippo signaling (GO:0035329)2.53719884
122microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.53108151
123ATP-dependent chromatin remodeling (GO:0043044)2.52979312
124negative regulation of histone modification (GO:0031057)2.52224078
125gene silencing (GO:0016458)2.52030714
126spliceosomal tri-snRNP complex assembly (GO:0000244)2.51811949
127nuclear envelope organization (GO:0006998)2.51088500
128paraxial mesoderm development (GO:0048339)2.51059512
129positive regulation of RNA splicing (GO:0033120)2.50094765
130metaphase plate congression (GO:0051310)2.49985427
131histone lysine demethylation (GO:0070076)2.49486489
132positive regulation of histone H3-K4 methylation (GO:0051571)2.49390670
133chromatin silencing (GO:0006342)2.49135142
134negative regulation of gene expression, epigenetic (GO:0045814)2.48654244
135negative regulation of DNA repair (GO:0045738)2.47394865
136mitotic metaphase plate congression (GO:0007080)2.46605061
137regulation of DNA damage checkpoint (GO:2000001)2.46203678

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human7.04144613
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.49582888
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.08080785
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.43595661
5MYC_22102868_ChIP-Seq_BL_Human3.24764235
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.95164970
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.89775274
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.87572117
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.77213563
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.62927053
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.56450405
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.49458960
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.32636143
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.27175881
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.26803967
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.19648156
17AR_21909140_ChIP-Seq_LNCAP_Human2.16994685
18TCF7_22412390_ChIP-Seq_EML_Mouse2.01042404
19E2F7_22180533_ChIP-Seq_HELA_Human11.9410658
20VDR_21846776_ChIP-Seq_THP-1_Human1.89531660
21KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.83561759
22* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.80955123
23* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.80014027
24XRN2_22483619_ChIP-Seq_HELA_Human1.75075873
25CIITA_25753668_ChIP-Seq_RAJI_Human1.72446552
26DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.72142897
27MYC_18358816_ChIP-ChIP_MESCs_Mouse1.71281254
28KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.70087523
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.66197982
30KDM2B_26808549_Chip-Seq_DND41_Human1.66076093
31FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.57640501
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.54838332
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.47487117
34ZFP281_27345836_Chip-Seq_ESCs_Mouse1.46701951
35TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.46653789
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45632224
37TTF2_22483619_ChIP-Seq_HELA_Human1.45623171
38* UTX_26944678_Chip-Seq_JUKART_Human1.45500117
39* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.43943168
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.42422606
41PKCTHETA_26484144_Chip-Seq_BREAST_Human1.41968046
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41609047
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.41378598
44* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37308966
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.35715176
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35572382
47KDM2B_26808549_Chip-Seq_JURKAT_Human1.34803668
48KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.32859861
49MAF_26560356_Chip-Seq_TH1_Human1.31676595
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29604717
51DCP1A_22483619_ChIP-Seq_HELA_Human1.27939874
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27419465
53TP63_17297297_ChIP-ChIP_HaCaT_Human1.26787793
54ZNF263_19887448_ChIP-Seq_K562_Human1.25300893
55ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23406422
56MYB_26560356_Chip-Seq_TH1_Human1.22119634
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21564709
58HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21107705
59* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18843798
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17783856
61P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16575850
62WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15827748
63SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.15146734
64FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.15089127
65SCL_19346495_ChIP-Seq_HPC-7_Human1.14332354
66KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.13805365
67ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13676738
68SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.13010858
69* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12543940
70MYB_26560356_Chip-Seq_TH2_Human1.10625838
71TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09226428
72EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09048843
73MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09018541
74BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08345386
75CHD1_26751641_Chip-Seq_LNCaP_Human1.08273451
76* NCOR1_26117541_ChIP-Seq_K562_Human1.07902844
77MYC_19079543_ChIP-ChIP_MESCs_Mouse1.07800074
78* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07706114
79YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07099245
80CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05401671
81ELK3_25401928_ChIP-Seq_HUVEC_Human1.05191252
82KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04108781
83BRD4_25478319_ChIP-Seq_HGPS_Human1.03912982
84SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03471492
85ETS1_20019798_ChIP-Seq_JURKAT_Human1.02530590
86CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.02203744
87E2F1_18555785_ChIP-Seq_MESCs_Mouse1.01621518
88* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.01511288
89VDR_24763502_ChIP-Seq_THP-1_Human1.00876507
90STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.00577701
91KDM5A_27292631_Chip-Seq_BREAST_Human0.99676262
92GABP_19822575_ChIP-Seq_HepG2_Human0.95950026
93NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93723019
94SPI1_23127762_ChIP-Seq_K562_Human0.93579085
95TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93477681
96* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.93212527
97* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93060659
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92085783
99TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91998558
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.91754083
101* SOX17_20123909_ChIP-Seq_XEN_Mouse0.91747823
102* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91685262
103ELK1_19687146_ChIP-ChIP_HELA_Human0.91628947
104ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.91527951
105POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91379268
106MYC_18555785_ChIP-Seq_MESCs_Mouse0.90312480
107SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90150771
108* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.89822275
109NANOG_21062744_ChIP-ChIP_HESCs_Human0.89062965
110DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88841591
111MYCN_18555785_ChIP-Seq_MESCs_Mouse0.88675826
112* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.87390434
113WT1_19549856_ChIP-ChIP_CCG9911_Human0.87239329
114KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.86045824
115ISL1_27105846_Chip-Seq_CPCs_Mouse0.84694502
116TFEB_21752829_ChIP-Seq_HELA_Human0.84297188
117ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84167966
118STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84061783
119EST1_17652178_ChIP-ChIP_JURKAT_Human0.83397758
120CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83251353
121* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.83182547
122ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.82925559
123TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.82575113
124GATA6_25053715_ChIP-Seq_YYC3_Human0.82513213
125E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82474046
126RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81827762
127* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.81625983
128FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81142740
129NELFA_20434984_ChIP-Seq_ESCs_Mouse0.80906877
130TP53_16413492_ChIP-PET_HCT116_Human0.80062689
131* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.79636744
132MYB_21317192_ChIP-Seq_ERMYB_Mouse0.79245977
133* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.79220447
134JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.78221117
135KDM2B_26808549_Chip-Seq_K562_Human0.76174257
136* CLOCK_20551151_ChIP-Seq_293T_Human0.75794755
137SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.75646280
138RUNX1_22412390_ChIP-Seq_EML_Mouse0.75161445
139CTNNB1_20460455_ChIP-Seq_HCT116_Human0.73145222
140ATF3_27146783_Chip-Seq_COLON_Human0.72993352
141* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.72976656
142SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.72853563
143FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.72170074
144FOXP3_21729870_ChIP-Seq_TREG_Human0.71986932
145FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.71849542
146* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.71389343
147TP53_22127205_ChIP-Seq_IMR90_Human0.70712194
148EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.69920117
149HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.68699275

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.62688539
2MP0003705_abnormal_hypodermis_morpholog3.04495948
3MP0010094_abnormal_chromosome_stability3.00904413
4MP0003111_abnormal_nucleus_morphology3.00686993
5MP0005076_abnormal_cell_differentiation2.95690766
6MP0010352_gastrointestinal_tract_polyps2.87201762
7MP0010307_abnormal_tumor_latency2.50779224
8MP0008057_abnormal_DNA_replication2.44620735
9MP0003077_abnormal_cell_cycle2.39261393
10MP0003121_genomic_imprinting2.36728754
11MP0003787_abnormal_imprinting2.34824538
12MP0002396_abnormal_hematopoietic_system2.28509666
13MP0009278_abnormal_bone_marrow2.23630090
14MP0003123_paternal_imprinting2.14236369
15MP0003300_gastrointestinal_ulcer2.13929439
16MP0004808_abnormal_hematopoietic_stem2.13808609
17MP0003693_abnormal_embryo_hatching2.07792027
18MP0005409_darkened_coat_color1.85089783
19MP0000350_abnormal_cell_proliferation1.76850802
20* MP0004197_abnormal_fetal_growth/weight/1.76449859
21MP0000733_abnormal_muscle_development1.71968465
22MP0004957_abnormal_blastocyst_morpholog1.70676961
23MP0001730_embryonic_growth_arrest1.66179458
24MP0001672_abnormal_embryogenesis/_devel1.63403887
25MP0005380_embryogenesis_phenotype1.63403887
26MP0002084_abnormal_developmental_patter1.63044308
27MP0002877_abnormal_melanocyte_morpholog1.61100309
28MP0003984_embryonic_growth_retardation1.56710136
29MP0003890_abnormal_embryonic-extraembry1.55474294
30MP0002088_abnormal_embryonic_growth/wei1.55327992
31MP0002086_abnormal_extraembryonic_tissu1.51247459
32MP0000537_abnormal_urethra_morphology1.48838481
33MP0008007_abnormal_cellular_replicative1.46527603
34MP0003566_abnormal_cell_adhesion1.45094421
35* MP0002085_abnormal_embryonic_tissue1.44523267
36MP0008877_abnormal_DNA_methylation1.43255289
37MP0000566_synostosis1.40346770
38MP0010030_abnormal_orbit_morphology1.38323939
39MP0002166_altered_tumor_susceptibility1.37343829
40MP0000428_abnormal_craniofacial_morphol1.37298989
41MP0010234_abnormal_vibrissa_follicle1.35617159
42MP0001697_abnormal_embryo_size1.34747601
43* MP0009703_decreased_birth_body1.33544392
44MP0003567_abnormal_fetal_cardiomyocyte1.30182270
45MP0003045_fibrosis1.29105945
46* MP0003935_abnormal_craniofacial_develop1.28005929
47MP0003385_abnormal_body_wall1.22756432
48MP0009672_abnormal_birth_weight1.21286537
49MP0003115_abnormal_respiratory_system1.21156858
50MP0003283_abnormal_digestive_organ1.20464426
51MP0001545_abnormal_hematopoietic_system1.19338385
52MP0005397_hematopoietic_system_phenotyp1.19338385
53MP0000703_abnormal_thymus_morphology1.19056501
54MP0002080_prenatal_lethality1.18642870
55MP0003942_abnormal_urinary_system1.18435697
56MP0002925_abnormal_cardiovascular_devel1.17480310
57MP0009697_abnormal_copulation1.17352883
58MP0008438_abnormal_cutaneous_collagen1.16286429
59MP0003937_abnormal_limbs/digits/tail_de1.16157537
60MP0003315_abnormal_perineum_morphology1.15682207
61MP0003941_abnormal_skin_development1.14680229
62MP0009053_abnormal_anal_canal1.14464544
63MP0001293_anophthalmia1.12307460
64MP0002092_abnormal_eye_morphology1.10099456
65MP0003091_abnormal_cell_migration1.09528589
66MP0003861_abnormal_nervous_system1.08911651
67MP0004185_abnormal_adipocyte_glucose1.07892812
68MP0001286_abnormal_eye_development1.06566927
69MP0001849_ear_inflammation1.05098992
70MP0006292_abnormal_olfactory_placode1.04220133
71MP0005187_abnormal_penis_morphology1.03929464
72MP0008961_abnormal_basal_metabolism1.02651296
73MP0002006_tumorigenesis1.02157476
74MP0006054_spinal_hemorrhage1.01742480
75MP0002697_abnormal_eye_size1.00910991
76MP0003122_maternal_imprinting1.00559967
77* MP0000432_abnormal_head_morphology0.99705295
78MP0001348_abnormal_lacrimal_gland0.98379377
79MP0008932_abnormal_embryonic_tissue0.98123834
80MP0001915_intracranial_hemorrhage0.97674177
81MP0000490_abnormal_crypts_of0.96373920
82MP0005623_abnormal_meninges_morphology0.96248234
83MP0005023_abnormal_wound_healing0.95621037
84MP0002928_abnormal_bile_duct0.95555571
85MP0000003_abnormal_adipose_tissue0.95456230
86MP0009379_abnormal_foot_pigmentation0.92032605
87MP0002932_abnormal_joint_morphology0.91515296
88MP0002019_abnormal_tumor_incidence0.89922104
89MP0005257_abnormal_intraocular_pressure0.89836113
90MP0001346_abnormal_lacrimal_gland0.89741005
91* MP0000266_abnormal_heart_morphology0.88846833
92MP0000371_diluted_coat_color0.88526897
93MP0010678_abnormal_skin_adnexa0.88308029
94MP0004264_abnormal_extraembryonic_tissu0.86394680
95MP0000313_abnormal_cell_death0.85792764
96MP0000383_abnormal_hair_follicle0.85410712
97MP0000534_abnormal_ureter_morphology0.84990818
98MP0002009_preneoplasia0.84743090
99MP0003303_peritoneal_inflammation0.84444196
100* MP0008058_abnormal_DNA_repair0.84408699
101MP0008770_decreased_survivor_rate0.83862585
102MP0002398_abnormal_bone_marrow0.83394860
103MP0003755_abnormal_palate_morphology0.83196810
104* MP0010630_abnormal_cardiac_muscle0.83180654
105MP0003943_abnormal_hepatobiliary_system0.83107021
106MP0002111_abnormal_tail_morphology0.82294427
107MP0001299_abnormal_eye_distance/0.82260758
108MP0005248_abnormal_Harderian_gland0.82250744
109MP0002249_abnormal_larynx_morphology0.82170670
110MP0000627_abnormal_mammary_gland0.81182603
111MP0002060_abnormal_skin_morphology0.80056700
112MP0002081_perinatal_lethality0.79668803
113MP0002233_abnormal_nose_morphology0.79539224
114MP0000767_abnormal_smooth_muscle0.79363961
115MP0005503_abnormal_tendon_morphology0.79347096
116MP0000762_abnormal_tongue_morphology0.78864122
117MP0000377_abnormal_hair_follicle0.77893400
118MP0003279_aneurysm0.76932691
119MP0004233_abnormal_muscle_weight0.76798059
120MP0005621_abnormal_cell_physiology0.76513856
121MP0005384_cellular_phenotype0.75264394
122MP0004272_abnormal_basement_membrane0.74499079
123MP0001661_extended_life_span0.74425679
124MP0005501_abnormal_skin_physiology0.74290329
125MP0002938_white_spotting0.73487357
126MP0003763_abnormal_thymus_physiology0.73330806
127* MP0002116_abnormal_craniofacial_bone0.72636593
128MP0002114_abnormal_axial_skeleton0.72548812
129MP0002210_abnormal_sex_determination0.70436083
130MP0000579_abnormal_nail_morphology0.68146269
131MP0002098_abnormal_vibrissa_morphology0.64273067
132MP0005408_hypopigmentation0.62912960
133MP0001340_abnormal_eyelid_morphology0.61952109

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.95700514
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.73642575
3Short 4th metacarpal (HP:0010044)3.73642575
4Abnormality of the fingertips (HP:0001211)3.62776210
5Cerebral aneurysm (HP:0004944)3.16275336
6Abnormality of the 4th metacarpal (HP:0010012)2.85933555
7Macroorchidism (HP:0000053)2.76377373
8Shallow orbits (HP:0000586)2.71184699
9Overlapping toe (HP:0001845)2.68340304
10Long eyelashes (HP:0000527)2.64390199
11* Increased nuchal translucency (HP:0010880)2.51991688
12High anterior hairline (HP:0009890)2.51082386
13Cortical dysplasia (HP:0002539)2.48454530
14Missing ribs (HP:0000921)2.47930424
15Trigonocephaly (HP:0000243)2.46009235
16* Insomnia (HP:0100785)2.43223240
17Chromsome breakage (HP:0040012)2.42969973
18Nephroblastoma (Wilms tumor) (HP:0002667)2.37546239
19Heterotopia (HP:0002282)2.37516252
20Deviation of the thumb (HP:0009603)2.34740426
21High pitched voice (HP:0001620)2.34009820
22Prominent nose (HP:0000448)2.33470252
23Astrocytoma (HP:0009592)2.31645628
24Abnormality of the astrocytes (HP:0100707)2.31645628
25Abnormality of the preputium (HP:0100587)2.30836457
26Ependymoma (HP:0002888)2.30765449
27Meckel diverticulum (HP:0002245)2.28729125
28Proximal placement of thumb (HP:0009623)2.28366769
29Ulnar bowing (HP:0003031)2.28275799
30Absent frontal sinuses (HP:0002688)2.27112208
31Ectopic kidney (HP:0000086)2.26009700
32Subacute progressive viral hepatitis (HP:0006572)2.24404777
33Embryonal renal neoplasm (HP:0011794)2.23673821
34Truncal obesity (HP:0001956)2.22383492
35* Abnormality of the carotid arteries (HP:0005344)2.20288270
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.17405076
37Increased density of long bones (HP:0006392)2.16085916
38Glioma (HP:0009733)2.14330078
39Abnormality of the ileum (HP:0001549)2.14275309
40Chromosomal breakage induced by crosslinking agents (HP:0003221)2.13775996
41Deep palmar crease (HP:0006191)2.13737202
42Broad palm (HP:0001169)2.13125560
43Narrow palate (HP:0000189)2.10341781
44Urethral obstruction (HP:0000796)2.08944399
45Termporal pattern (HP:0011008)2.08578996
46Insidious onset (HP:0003587)2.08578996
47Broad thumb (HP:0011304)2.07850400
4811 pairs of ribs (HP:0000878)2.06972074
49Abnormality of the phalanges of the hallux (HP:0010057)2.04409138
50* Obsessive-compulsive behavior (HP:0000722)2.02048626
51Deep philtrum (HP:0002002)2.01724164
52* Overriding aorta (HP:0002623)2.01702843
53Medulloblastoma (HP:0002885)2.01549452
54* Elfin facies (HP:0004428)2.01017076
55Vertebral arch anomaly (HP:0008438)1.99900326
56Sparse lateral eyebrow (HP:0005338)1.98501898
57Birth length less than 3rd percentile (HP:0003561)1.97877671
58Duodenal stenosis (HP:0100867)1.96429172
59Small intestinal stenosis (HP:0012848)1.96429172
60* Hyperacusis (HP:0010780)1.96366087
61Myelodysplasia (HP:0002863)1.95154657
62Relative macrocephaly (HP:0004482)1.94980140
63Enlarged penis (HP:0000040)1.94687153
64Reticulocytopenia (HP:0001896)1.94602661
65Malignant gastrointestinal tract tumors (HP:0006749)1.94253904
66Gastrointestinal carcinoma (HP:0002672)1.94253904
67Diastasis recti (HP:0001540)1.94196464
68Limited elbow extension (HP:0001377)1.92623472
69Papillary thyroid carcinoma (HP:0002895)1.92515423
70* Renovascular hypertension (HP:0100817)1.92471171
71Septate vagina (HP:0001153)1.92434021
72Duplication of thumb phalanx (HP:0009942)1.92184645
73Mesomelia (HP:0003027)1.91525577
74Sandal gap (HP:0001852)1.90625120
75Supernumerary ribs (HP:0005815)1.90540106
76Cutis marmorata (HP:0000965)1.90473111
77Lip pit (HP:0100267)1.90275385
78Skull defect (HP:0001362)1.90178657
79Abnormality of the distal phalanx of the thumb (HP:0009617)1.88536421
80Skin tags (HP:0010609)1.86745133
81* Patellar dislocation (HP:0002999)1.86223205
82Anal stenosis (HP:0002025)1.84457126
83Neoplasm of the oral cavity (HP:0100649)1.83483047
84Abnormality of the calcaneus (HP:0008364)1.82844662
85Syringomyelia (HP:0003396)1.82790113
86Spinal cord lesions (HP:0100561)1.82790113
87Low anterior hairline (HP:0000294)1.82546576
88Mitral valve prolapse (HP:0001634)1.82304519
89Asymmetry of the thorax (HP:0001555)1.80784141
90Dysmetric saccades (HP:0000641)1.80690526
91Abnormality of chromosome stability (HP:0003220)1.80275169
92Aneurysm (HP:0002617)1.78916767
93Aortic aneurysm (HP:0004942)1.78064990
94Choanal atresia (HP:0000453)1.77023823
95Transitional cell carcinoma of the bladder (HP:0006740)1.75765612
96Atresia of the external auditory canal (HP:0000413)1.75515822
97Arteriovenous malformation (HP:0100026)1.74960521
98Broad phalanges of the hand (HP:0009768)1.74302501
99Hypopigmentation of the fundus (HP:0007894)1.74075353
100Abnormal number of incisors (HP:0011064)1.73970783
101Ankle contracture (HP:0006466)1.73748070
102Microglossia (HP:0000171)1.73747997
103Absent radius (HP:0003974)1.71800199
104Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.71654196
105Rectal prolapse (HP:0002035)1.70770848
106Abnormality of chromosome segregation (HP:0002916)1.70343447
107Smooth philtrum (HP:0000319)1.70031570
108Abnormality of the duodenum (HP:0002246)1.69995384
109Neonatal hypoglycemia (HP:0001998)1.69649713
110Leiomyosarcoma (HP:0100243)1.68662181
111Uterine leiomyosarcoma (HP:0002891)1.68662181
112Abnormality of oral frenula (HP:0000190)1.68261361
113Hypoplasia of the maxilla (HP:0000327)1.67921826
114Disproportionate tall stature (HP:0001519)1.67738541
115Facial hemangioma (HP:0000329)1.67650331
116* Bowel diverticulosis (HP:0005222)1.67305874
117Colon cancer (HP:0003003)1.67241535
118Ankyloglossia (HP:0010296)1.67084857
119Pseudobulbar signs (HP:0002200)1.66792508
120Thick eyebrow (HP:0000574)1.66549224
121Cafe-au-lait spot (HP:0000957)1.65875943
122Embryonal neoplasm (HP:0002898)1.65432930
123* Renal duplication (HP:0000075)1.65415929
124Neoplasm of striated muscle (HP:0009728)1.64350932
125Hepatoblastoma (HP:0002884)1.64277906
126Broad finger (HP:0001500)1.63930803
127* Radioulnar synostosis (HP:0002974)1.61958049
128* Pointed chin (HP:0000307)1.61600094
129Dislocated radial head (HP:0003083)1.61207818
130Chin dimple (HP:0010751)1.60571649
131Microtia (HP:0008551)1.60446606
132Bladder carcinoma (HP:0002862)1.59924039
133Bladder neoplasm (HP:0009725)1.59924039
134Selective tooth agenesis (HP:0001592)1.59602926
135Radial bowing (HP:0002986)1.58748113
136Neoplasm of the adrenal cortex (HP:0100641)1.58167011
137Supernumerary bones of the axial skeleton (HP:0009144)1.58002188
138Preauricular skin tag (HP:0000384)1.57412832
139Long clavicles (HP:0000890)1.56465575
140Abnormality of cochlea (HP:0000375)1.56263596
141Short 1st metacarpal (HP:0010034)1.56163187
142Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.56163187
143Rhabdomyosarcoma (HP:0002859)1.55760446
144Broad phalanx (HP:0006009)1.54875986
145Midline defect of the nose (HP:0004122)1.54620942
146* Attention deficit hyperactivity disorder (HP:0007018)1.54350129
147Hypochromic microcytic anemia (HP:0004840)1.53764810
148Capillary hemangiomas (HP:0005306)1.53290793
149Acute myeloid leukemia (HP:0004808)1.53174040
150Hematochezia (HP:0002573)1.53031914
151Viral hepatitis (HP:0006562)1.51898168
152Absent forearm bone (HP:0003953)1.51440793
153Aplasia involving forearm bones (HP:0009822)1.51440793
154Cystic hygroma (HP:0000476)1.51367828

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.67482176
2CDC73.74318127
3EEF2K3.38486299
4MAP3K102.92855022
5TRIB32.69203371
6PKN22.65707824
7LATS12.46437369
8NEK22.43356671
9EIF2AK12.33156456
10SMG12.29191033
11BRD42.29089205
12CAMK1D2.18212997
13PNCK2.11950250
14TSSK62.07132551
15PLK42.04056589
16TTN1.98693033
17CAMK1G1.97215692
18BUB11.76341448
19TTK1.75679087
20CDK61.75142717
21LATS21.71886848
22PDGFRA1.69441219
23PTK61.65769656
24CDK41.61808644
25ALK1.61133455
26ATR1.53629583
27MTOR1.50663964
28SIK11.44583727
29PBK1.44376629
30STK101.42122571
31STK31.40403750
32RIPK11.38896683
33MST1R1.35934092
34SIK21.34687444
35TAF11.34290354
36PASK1.25512934
37STK41.24757112
38DMPK1.23423920
39CHEK11.21907089
40FGFR31.21284145
41CDK91.16235415
42ATM1.11904971
43CHEK21.08974041
44RPS6KB21.08550414
45SCYL21.03258014
46AURKB1.03020238
47BRSK11.02950632
48ZAK1.02915842
49FGFR21.02103684
50MKNK11.02058617
51PDGFRB1.00911660
52MAP4K10.98002972
53CDK80.97980690
54MET0.94364817
55MAP3K90.92039298
56CDK20.91164228
57SRPK10.89099944
58MAP3K80.88832311
59MELK0.88770878
60PLK10.88730342
61PAK20.86364597
62PRPF4B0.85417195
63CDK70.85163115
64RPS6KA40.84911230
65MKNK20.84480381
66LRRK20.82649047
67KSR10.82524000
68EPHA20.80626573
69PRKCH0.78987203
70ICK0.78321944
71EIF2AK30.75200169
72FGFR10.74986746
73PAK40.74308947
74JAK10.73872128
75CDK10.73701800
76KSR20.72751668
77BMX0.72268714
78AKT30.69573363
79SGK30.69519221
80DDR20.69514531
81PRKDC0.69488902
82PIM10.68406870
83PLK30.68330126
84AURKA0.68018649
85CDC42BPA0.66313809
86IRAK30.66117733
87HIPK20.64939343
88ERBB40.64480636
89FGFR40.64369043
90NEK10.63804601
91EIF2AK20.63586344
92FRK0.63034691
93MAP3K70.62944578
94* MAPK140.62720642
95TGFBR10.62281017
96CDK30.62065616
97CSNK1D0.61858732
98CSF1R0.60278523
99BRAF0.57663000
100RAF10.57645717
101TRPM70.55990080
102JAK30.53188640
103NEK60.53159320
104CHUK0.52772822
105AKT10.52665447
106CLK10.50489974
107GSK3B0.49678753
108PTK20.49591669
109NEK90.48302981
110NUAK10.46496352
111NTRK10.46035598
112AKT20.45623767
113MAPK110.45337385
114MAPK10.44875544
115HCK0.44844426
116FLT30.44316657
117BRSK20.44192664
118ERBB20.43890644
119TLK10.43292037
120RPS6KB10.43201400
121* CSNK1E0.42773729
122ITK0.41827764
123MAPK80.41798032
124WNK10.40750827
125RET0.40736704
126WEE10.39493511
127STK38L0.39393971
128TYRO30.39090682
129MAPK100.38730441
130DYRK1B0.37693531
131GRK60.36760846
132TYK20.36450888
133* CSNK2A20.36191245
134PRKCI0.34804065
135YES10.33591417

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041102.18768378
2DNA replication_Homo sapiens_hsa030302.18215023
3Lysine degradation_Homo sapiens_hsa003102.13833662
4Chronic myeloid leukemia_Homo sapiens_hsa052201.93577207
5MicroRNAs in cancer_Homo sapiens_hsa052061.79565547
6mRNA surveillance pathway_Homo sapiens_hsa030151.77554199
7Mismatch repair_Homo sapiens_hsa034301.70448883
8One carbon pool by folate_Homo sapiens_hsa006701.67851190
9Small cell lung cancer_Homo sapiens_hsa052221.62027147
10RNA transport_Homo sapiens_hsa030131.53652077
11Non-homologous end-joining_Homo sapiens_hsa034501.48540950
12Fanconi anemia pathway_Homo sapiens_hsa034601.47126861
13Non-small cell lung cancer_Homo sapiens_hsa052231.44809854
14Systemic lupus erythematosus_Homo sapiens_hsa053221.43118120
15Adherens junction_Homo sapiens_hsa045201.41135986
16mTOR signaling pathway_Homo sapiens_hsa041501.40248420
17Spliceosome_Homo sapiens_hsa030401.39301073
18Transcriptional misregulation in cancer_Homo sapiens_hsa052021.38442405
19Viral carcinogenesis_Homo sapiens_hsa052031.38248606
20HTLV-I infection_Homo sapiens_hsa051661.35338476
21Basal transcription factors_Homo sapiens_hsa030221.34174433
22Proteoglycans in cancer_Homo sapiens_hsa052051.31223699
23Pancreatic cancer_Homo sapiens_hsa052121.30682471
24Base excision repair_Homo sapiens_hsa034101.30402577
25Colorectal cancer_Homo sapiens_hsa052101.26233070
26Notch signaling pathway_Homo sapiens_hsa043301.22963774
27Thyroid hormone signaling pathway_Homo sapiens_hsa049191.22322219
28Endometrial cancer_Homo sapiens_hsa052131.19493709
29Basal cell carcinoma_Homo sapiens_hsa052171.19330422
30Glioma_Homo sapiens_hsa052141.19187372
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.17861933
32p53 signaling pathway_Homo sapiens_hsa041151.17798683
33B cell receptor signaling pathway_Homo sapiens_hsa046621.17766751
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.16860856
35Prostate cancer_Homo sapiens_hsa052151.16625270
36Viral myocarditis_Homo sapiens_hsa054161.14140158
37Homologous recombination_Homo sapiens_hsa034401.13725243
38Focal adhesion_Homo sapiens_hsa045101.12044424
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.10097952
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08865591
41Type II diabetes mellitus_Homo sapiens_hsa049301.00863412
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99360040
43Herpes simplex infection_Homo sapiens_hsa051680.98722334
44Primary immunodeficiency_Homo sapiens_hsa053400.97525963
45Hepatitis B_Homo sapiens_hsa051610.96906668
46Hippo signaling pathway_Homo sapiens_hsa043900.96101529
47Antigen processing and presentation_Homo sapiens_hsa046120.95613003
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95512460
49Biosynthesis of amino acids_Homo sapiens_hsa012300.95243377
50Acute myeloid leukemia_Homo sapiens_hsa052210.92753923
51Neurotrophin signaling pathway_Homo sapiens_hsa047220.91825744
52FoxO signaling pathway_Homo sapiens_hsa040680.91389146
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91090349
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89994262
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.89654988
56TGF-beta signaling pathway_Homo sapiens_hsa043500.88928723
57Platelet activation_Homo sapiens_hsa046110.88590613
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.87934956
59T cell receptor signaling pathway_Homo sapiens_hsa046600.87854109
60Vitamin B6 metabolism_Homo sapiens_hsa007500.87787236
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.86730167
62Pathways in cancer_Homo sapiens_hsa052000.85565319
63Pyrimidine metabolism_Homo sapiens_hsa002400.84841320
64Insulin resistance_Homo sapiens_hsa049310.84498585
65Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84143467
66Dorso-ventral axis formation_Homo sapiens_hsa043200.83584909
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.83149754
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.83096196
69Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.82879698
70RNA degradation_Homo sapiens_hsa030180.81194553
71Wnt signaling pathway_Homo sapiens_hsa043100.80990278
72Oocyte meiosis_Homo sapiens_hsa041140.80361843
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79694672
74Thyroid cancer_Homo sapiens_hsa052160.79328058
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78597975
76Alcoholism_Homo sapiens_hsa050340.77924446
77Bladder cancer_Homo sapiens_hsa052190.76964269
78Toxoplasmosis_Homo sapiens_hsa051450.76037249
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75626565
80AMPK signaling pathway_Homo sapiens_hsa041520.75229964
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74928803
82Prolactin signaling pathway_Homo sapiens_hsa049170.74871706
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74849186
84Estrogen signaling pathway_Homo sapiens_hsa049150.74766604
85Osteoclast differentiation_Homo sapiens_hsa043800.73876621
86Measles_Homo sapiens_hsa051620.71562213
87Nucleotide excision repair_Homo sapiens_hsa034200.71417417
88Apoptosis_Homo sapiens_hsa042100.71388571
89ECM-receptor interaction_Homo sapiens_hsa045120.70691122
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70345304
91VEGF signaling pathway_Homo sapiens_hsa043700.68487654
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67591967
93Melanoma_Homo sapiens_hsa052180.66590452
94RNA polymerase_Homo sapiens_hsa030200.66519083
95Ribosome_Homo sapiens_hsa030100.66419120
96Tight junction_Homo sapiens_hsa045300.65240960
97Selenocompound metabolism_Homo sapiens_hsa004500.64063767
98Insulin signaling pathway_Homo sapiens_hsa049100.63446064
99Hedgehog signaling pathway_Homo sapiens_hsa043400.63411682
100Renal cell carcinoma_Homo sapiens_hsa052110.60910569
101Jak-STAT signaling pathway_Homo sapiens_hsa046300.60563562
102Melanogenesis_Homo sapiens_hsa049160.59489660
103Pyruvate metabolism_Homo sapiens_hsa006200.59401996
104Chemokine signaling pathway_Homo sapiens_hsa040620.59234772
105HIF-1 signaling pathway_Homo sapiens_hsa040660.58863768
106Inositol phosphate metabolism_Homo sapiens_hsa005620.57859917
107Rap1 signaling pathway_Homo sapiens_hsa040150.57639916
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57184488
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56812374
110ErbB signaling pathway_Homo sapiens_hsa040120.56158753
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.55534787
112Epstein-Barr virus infection_Homo sapiens_hsa051690.55198683
113Choline metabolism in cancer_Homo sapiens_hsa052310.55184336
114MAPK signaling pathway_Homo sapiens_hsa040100.53927031
115TNF signaling pathway_Homo sapiens_hsa046680.53161780
116Leishmaniasis_Homo sapiens_hsa051400.52906965
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52651627
118Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52547346
119Pentose phosphate pathway_Homo sapiens_hsa000300.51884165
120Thyroid hormone synthesis_Homo sapiens_hsa049180.49925558
121Carbon metabolism_Homo sapiens_hsa012000.48648924
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42804983
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41026100
124Purine metabolism_Homo sapiens_hsa002300.40273688
125Axon guidance_Homo sapiens_hsa043600.39949459
1262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38295517
127N-Glycan biosynthesis_Homo sapiens_hsa005100.38160519
128Glucagon signaling pathway_Homo sapiens_hsa049220.37799134
129Gap junction_Homo sapiens_hsa045400.37559053
130Prion diseases_Homo sapiens_hsa050200.35255672

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