BAZ2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the bromodomain gene family. Members of this gene family encode proteins that are integral components of chromatin remodeling complexes. The encoded protein showed strong preference for the activating H3K14Ac mark in a histone peptide screen, suggesting a potential role in transcriptional activation. This gene may be associated with susceptibility to sudden cardiac death (SCD). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K4 trimethylation (GO:0080182)5.12283646
2pyrimidine nucleobase catabolic process (GO:0006208)4.58121086
3photoreceptor cell differentiation (GO:0046530)4.30078405
4eye photoreceptor cell differentiation (GO:0001754)4.30078405
5axon ensheathment in central nervous system (GO:0032291)4.14185429
6central nervous system myelination (GO:0022010)4.14185429
7behavioral response to nicotine (GO:0035095)3.96437439
8photoreceptor cell maintenance (GO:0045494)3.82299794
9nucleobase catabolic process (GO:0046113)3.76532781
10negative regulation of cytosolic calcium ion concentration (GO:0051481)3.58950747
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.55136992
12establishment of protein localization to Golgi (GO:0072600)3.53602788
13peptidyl-lysine trimethylation (GO:0018023)3.50750051
14detection of light stimulus involved in sensory perception (GO:0050962)3.45996320
15detection of light stimulus involved in visual perception (GO:0050908)3.45996320
16centriole replication (GO:0007099)3.44259899
17auditory behavior (GO:0031223)3.42989316
18negative regulation of neurotransmitter secretion (GO:0046929)3.34331093
19axonal fasciculation (GO:0007413)3.31939240
20establishment of nucleus localization (GO:0040023)3.25152290
21mechanosensory behavior (GO:0007638)3.24545796
22positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.22725997
23postsynaptic membrane organization (GO:0001941)3.18960999
24rhodopsin mediated signaling pathway (GO:0016056)3.16853129
25regulation of rhodopsin mediated signaling pathway (GO:0022400)3.16706698
26dendritic spine morphogenesis (GO:0060997)3.14341108
27negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.13343194
28negative regulation of translation, ncRNA-mediated (GO:0040033)3.13343194
29regulation of translation, ncRNA-mediated (GO:0045974)3.13343194
30retina layer formation (GO:0010842)3.10665869
31neuron cell-cell adhesion (GO:0007158)3.09898847
32limb bud formation (GO:0060174)3.09809485
33central nervous system projection neuron axonogenesis (GO:0021952)3.08594645
34protein targeting to Golgi (GO:0000042)3.07921891
35protein polyglutamylation (GO:0018095)3.07028082
36epithelial cilium movement (GO:0003351)3.04688798
37retinal ganglion cell axon guidance (GO:0031290)3.04456586
38histone H3-K4 methylation (GO:0051568)3.04096729
39behavioral response to ethanol (GO:0048149)3.03139437
40cerebral cortex cell migration (GO:0021795)3.00895073
41protein localization to cilium (GO:0061512)2.99627470
42histone H3-K9 methylation (GO:0051567)2.99386854
43myelination (GO:0042552)2.97468007
44nucleus localization (GO:0051647)2.94954733
45retrograde transport, vesicle recycling within Golgi (GO:0000301)2.94483519
46centriole assembly (GO:0098534)2.94338641
47histone H3-K9 modification (GO:0061647)2.93864630
48nonmotile primary cilium assembly (GO:0035058)2.93351762
49ensheathment of neurons (GO:0007272)2.93145627
50axon ensheathment (GO:0008366)2.93145627
51intraciliary transport (GO:0042073)2.92433313
52membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.90218657
53regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.89877063
54leukocyte migration involved in inflammatory response (GO:0002523)2.89387258
55central nervous system neuron axonogenesis (GO:0021955)2.87917388
56forebrain neuron differentiation (GO:0021879)2.86435931
57regulation of cilium movement (GO:0003352)2.85922533
58neuron recognition (GO:0008038)2.85687116
59axoneme assembly (GO:0035082)2.85435726
60histone H3-K36 demethylation (GO:0070544)2.83148397
61response to lipoprotein particle (GO:0055094)2.83013915
62neutrophil activation (GO:0042119)2.82663273
63olfactory bulb development (GO:0021772)2.79884371
64neutrophil activation involved in immune response (GO:0002283)2.79065108
65neuronal action potential (GO:0019228)2.78884504
66presynaptic membrane assembly (GO:0097105)2.76642430
67cilium morphogenesis (GO:0060271)2.75511099
68eye photoreceptor cell development (GO:0042462)2.75239031
69neurotransmitter-gated ion channel clustering (GO:0072578)2.72833293
70peptidyl-tyrosine autophosphorylation (GO:0038083)2.72597360
71cilium movement (GO:0003341)2.71310275
72transmission of nerve impulse (GO:0019226)2.70832891
73cilium organization (GO:0044782)2.70253393
74substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.70078007
75substrate-independent telencephalic tangential migration (GO:0021826)2.70078007
76neuronal stem cell maintenance (GO:0097150)2.69060631
77head development (GO:0060322)2.68386369
78negative regulation of mast cell activation (GO:0033004)2.67864292
79auditory receptor cell differentiation (GO:0042491)2.67788936
80cilium assembly (GO:0042384)2.67068086
81reflex (GO:0060004)2.66875218
82G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.66050171
83synapse assembly (GO:0007416)2.65865402
84photoreceptor cell development (GO:0042461)2.65146224
85atrial cardiac muscle cell action potential (GO:0086014)2.63941902
86regulation of heat generation (GO:0031650)2.62405703
87neuronal action potential propagation (GO:0019227)2.60611524
88microtubule anchoring (GO:0034453)2.59759704
89interkinetic nuclear migration (GO:0022027)2.59544414
90cilium or flagellum-dependent cell motility (GO:0001539)2.57717718
91membrane depolarization during action potential (GO:0086010)2.57084498
92adult walking behavior (GO:0007628)2.55633033
93fucose catabolic process (GO:0019317)2.54794475
94L-fucose metabolic process (GO:0042354)2.54794475
95L-fucose catabolic process (GO:0042355)2.54794475
96histone H2B ubiquitination (GO:0033523)2.53009809
97hindbrain development (GO:0030902)2.52870160
98cell proliferation in forebrain (GO:0021846)2.52850741
99protein localization to Golgi apparatus (GO:0034067)2.52660959
100cAMP catabolic process (GO:0006198)2.52293338
101detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.51607977
102C4-dicarboxylate transport (GO:0015740)2.49229066
103regulation of DNA endoreduplication (GO:0032875)2.47985877
104inner ear receptor cell differentiation (GO:0060113)2.47620852
105regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.47326366
106positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.47326366
107presynaptic membrane organization (GO:0097090)2.46425039
108cranial nerve development (GO:0021545)2.45698238
109gamma-aminobutyric acid transport (GO:0015812)2.44782408
110regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.44694346
111positive regulation of oligodendrocyte differentiation (GO:0048714)2.44179547
112retinal cone cell development (GO:0046549)2.43475008
113embryonic retina morphogenesis in camera-type eye (GO:0060059)2.42976406
114response to auditory stimulus (GO:0010996)2.41639153
115inner ear receptor stereocilium organization (GO:0060122)2.41407424
116spinal cord motor neuron differentiation (GO:0021522)2.41167631
117phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.40878448
118glutamate receptor signaling pathway (GO:0007215)2.39729072
119dendrite morphogenesis (GO:0048813)2.39147040
120regulation of action potential (GO:0098900)2.38473035
121indolalkylamine metabolic process (GO:0006586)2.38421898
122brain morphogenesis (GO:0048854)2.36821397
123cerebral cortex radially oriented cell migration (GO:0021799)2.35847796
124negative regulation of neurotransmitter transport (GO:0051589)2.35672798
125long-chain fatty acid biosynthetic process (GO:0042759)2.34920762
126asymmetric protein localization (GO:0008105)2.34646873
127calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.34052286
128somite development (GO:0061053)2.33970843
129response to muramyl dipeptide (GO:0032495)2.33868970
130telencephalon cell migration (GO:0022029)2.33695807
131granulocyte activation (GO:0036230)2.33558873
132positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.32099963
133regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.32099963
134preassembly of GPI anchor in ER membrane (GO:0016254)2.31267806
135cornea development in camera-type eye (GO:0061303)2.30548223
136oligodendrocyte differentiation (GO:0048709)2.27701512
137establishment of mitotic spindle orientation (GO:0000132)2.27082212
138positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.27009136
139appendage development (GO:0048736)2.26646025
140limb development (GO:0060173)2.26646025
141histone lysine methylation (GO:0034968)2.26110629
142poly(A)+ mRNA export from nucleus (GO:0016973)2.26032021
143negative regulation of transcription by competitive promoter binding (GO:0010944)2.24760617
144import into cell (GO:0098657)2.23955046
145neural tube formation (GO:0001841)2.23351731
146cytoplasmic mRNA processing body assembly (GO:0033962)2.23332012
147sympathetic nervous system development (GO:0048485)2.22507617
148regulation of somitogenesis (GO:0014807)2.22403079
149neutrophil mediated immunity (GO:0002446)2.21660901
150negative regulation of execution phase of apoptosis (GO:1900118)2.18527995
151negative regulation of myoblast differentiation (GO:0045662)2.18358083
152peptidyl-lysine methylation (GO:0018022)2.17252210
153regulation of pigment cell differentiation (GO:0050932)2.15926296
154Golgi to plasma membrane protein transport (GO:0043001)2.15759807
155magnesium ion transport (GO:0015693)2.15671594
156lateral sprouting from an epithelium (GO:0060601)2.15186039
157lymphoid progenitor cell differentiation (GO:0002320)2.15136659
158positive regulation of cell fate commitment (GO:0010455)2.13223380
159retinal rod cell development (GO:0046548)2.12538578
160Golgi to endosome transport (GO:0006895)2.11306784
161myelination in peripheral nervous system (GO:0022011)2.10827191
162peripheral nervous system axon ensheathment (GO:0032292)2.10827191
163energy homeostasis (GO:0097009)2.09603728
164mitotic sister chromatid cohesion (GO:0007064)2.07133478
165regulation of collateral sprouting (GO:0048670)2.06788395
166activated T cell proliferation (GO:0050798)2.06758566
167cell differentiation in spinal cord (GO:0021515)2.06537733
168developmental pigmentation (GO:0048066)2.05853430
169regulation of histone H3-K4 methylation (GO:0051569)2.05250542
170B cell homeostasis (GO:0001782)2.04945911
171response to redox state (GO:0051775)2.04094909
172Sertoli cell development (GO:0060009)2.03248303
173cyclic nucleotide catabolic process (GO:0009214)2.02395323
174sensory perception of light stimulus (GO:0050953)2.01678038

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.88221749
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.87099919
3GBX2_23144817_ChIP-Seq_PC3_Human2.86479760
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.44337690
5ZNF274_21170338_ChIP-Seq_K562_Hela2.38025444
6VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.31453730
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.22168592
8CDX2_19796622_ChIP-Seq_MESCs_Mouse2.09294845
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.04767458
10ZFP57_27257070_Chip-Seq_ESCs_Mouse1.97157393
11PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83610512
12IGF1R_20145208_ChIP-Seq_DFB_Human1.83074003
13SMAD_19615063_ChIP-ChIP_OVARY_Human1.72187827
14PCGF2_27294783_Chip-Seq_NPCs_Mouse1.71480497
15SALL1_21062744_ChIP-ChIP_HESCs_Human1.69798922
16* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69606032
17* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.68207689
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67818300
19PIAS1_25552417_ChIP-Seq_VCAP_Human1.66513655
20* NANOG_18555785_Chip-Seq_ESCs_Mouse1.62815921
21REST_21632747_ChIP-Seq_MESCs_Mouse1.58432861
22RBPJ_22232070_ChIP-Seq_NCS_Mouse1.58305384
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57623347
24NR3C1_21868756_ChIP-Seq_MCF10A_Human1.57351692
25TAF15_26573619_Chip-Seq_HEK293_Human1.55498560
26ZNF217_24962896_ChIP-Seq_MCF-7_Human1.55308905
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54929876
28AR_25329375_ChIP-Seq_VCAP_Human1.54442734
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54350014
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53878964
31CBP_20019798_ChIP-Seq_JUKART_Human1.53878964
32FUS_26573619_Chip-Seq_HEK293_Human1.53581611
33* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53385046
34AR_21572438_ChIP-Seq_LNCaP_Human1.53182576
35* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51971327
36SCL_19346495_ChIP-Seq_HPC-7_Human1.50638731
37SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50605292
38P300_19829295_ChIP-Seq_ESCs_Human1.50477716
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46942974
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.46646858
41* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.46268337
42OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46037037
43* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.45866466
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45017537
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.43981838
46AHR_22903824_ChIP-Seq_MCF-7_Human1.43590106
47FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.43508199
48BCAT_22108803_ChIP-Seq_LS180_Human1.42564255
49ER_23166858_ChIP-Seq_MCF-7_Human1.42111223
50POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41914368
51TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41914368
52CMYC_18555785_Chip-Seq_ESCs_Mouse1.41766387
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.41127660
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.39168182
55* STAT3_23295773_ChIP-Seq_U87_Human1.38814982
56* E2F1_18555785_Chip-Seq_ESCs_Mouse1.38546829
57IRF8_22096565_ChIP-ChIP_GC-B_Human1.36791353
58JARID2_20064375_ChIP-Seq_MESCs_Mouse1.34947363
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.34155813
60EWS_26573619_Chip-Seq_HEK293_Human1.33497487
61* P53_22387025_ChIP-Seq_ESCs_Mouse1.33194929
62ARNT_22903824_ChIP-Seq_MCF-7_Human1.33168833
63* P300_18555785_Chip-Seq_ESCs_Mouse1.32294378
64STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.31729163
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.30872908
66WT1_19549856_ChIP-ChIP_CCG9911_Human1.29313627
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29304192
68* TCF4_23295773_ChIP-Seq_U87_Human1.29253414
69VDR_22108803_ChIP-Seq_LS180_Human1.28070938
70ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27619034
71* STAT3_18555785_Chip-Seq_ESCs_Mouse1.27569720
72NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26701044
73TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26511631
74SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.26494221
75VDR_24787735_ChIP-Seq_THP-1_Human1.24949273
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24251277
77P53_22127205_ChIP-Seq_FIBROBLAST_Human1.24195913
78* SOX2_21211035_ChIP-Seq_LN229_Gbm1.23959714
79RUNX_20019798_ChIP-Seq_JUKART_Human1.23656638
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23436447
81SMAD4_21799915_ChIP-Seq_A2780_Human1.23016723
82FLI1_21867929_ChIP-Seq_TH2_Mouse1.22973067
83Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.22894509
84PRDM14_20953172_ChIP-Seq_ESCs_Human1.22347166
85IRF8_21731497_ChIP-ChIP_J774_Mouse1.21979069
86PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21950708
87RNF2_27304074_Chip-Seq_NSC_Mouse1.21319356
88TCF4_22108803_ChIP-Seq_LS180_Human1.21172261
89* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.21149242
90TAL1_26923725_Chip-Seq_HPCs_Mouse1.19320904
91RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19301769
92FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18633858
93* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16861914
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16409012
95* OCT4_18555785_Chip-Seq_ESCs_Mouse1.16366430
96LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16224711
97TP53_16413492_ChIP-PET_HCT116_Human1.15648544
98* NMYC_18555785_Chip-Seq_ESCs_Mouse1.15406197
99CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14584264
100RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14116725
101KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13682737
102KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13354785
103* SOX2_18555785_Chip-Seq_ESCs_Mouse1.12020241
104* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11085906
105KDM2B_26808549_Chip-Seq_REH_Human1.11073494
106EZH2_22144423_ChIP-Seq_EOC_Human1.10053351
107* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.10004668
108GATA2_21666600_ChIP-Seq_HMVEC_Human1.09484333
109STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.09419975
110IRF8_27001747_Chip-Seq_BMDM_Mouse1.09399819
111CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09067508
112TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07460460
113* KLF4_18555785_Chip-Seq_ESCs_Mouse1.07346886
114POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07253300
115RXR_22108803_ChIP-Seq_LS180_Human1.06841189
116DROSHA_22980978_ChIP-Seq_HELA_Human1.06167876
117TBL1_22424771_ChIP-Seq_293T_Human1.06148215
118CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05879970
119STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05313392
120IRF1_19129219_ChIP-ChIP_H3396_Human1.05281955
121* ZFX_18555785_Chip-Seq_ESCs_Mouse1.03399329
122* PU1_27457419_Chip-Seq_LIVER_Mouse1.02034508
123NANOG_19829295_ChIP-Seq_ESCs_Human1.01977893
124SOX2_19829295_ChIP-Seq_ESCs_Human1.01977893
125CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01413976
126RUNX2_22187159_ChIP-Seq_PCA_Human1.01382871
127* CTCF_18555785_Chip-Seq_ESCs_Mouse1.01276199
128TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01241891
129CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01050249
130SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.00277206
131SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00227465
132SMAD4_21741376_ChIP-Seq_EPCs_Human1.00131439
133SMAD1_18555785_Chip-Seq_ESCs_Mouse0.99360585
134RNF2_27304074_Chip-Seq_ESCs_Mouse0.99291180
135EED_16625203_ChIP-ChIP_MESCs_Mouse0.99128930
136EZH2_27304074_Chip-Seq_ESCs_Mouse0.98472521

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005409_darkened_coat_color3.06951342
2MP0006292_abnormal_olfactory_placode2.94502559
3MP0000569_abnormal_digit_pigmentation2.90776824
4MP0005551_abnormal_eye_electrophysiolog2.90150425
5MP0006072_abnormal_retinal_apoptosis2.87790636
6MP0003880_abnormal_central_pattern2.83219651
7MP0003787_abnormal_imprinting2.80215547
8MP0005253_abnormal_eye_physiology2.57738113
9MP0003950_abnormal_plasma_membrane2.48973511
10MP0000383_abnormal_hair_follicle2.42868469
11MP0003122_maternal_imprinting2.28437935
12MP0005423_abnormal_somatic_nervous2.28371895
13MP0000920_abnormal_myelination2.21906977
14MP0002822_catalepsy2.09465437
15MP0008057_abnormal_DNA_replication2.06189025
16MP0003183_abnormal_peptide_metabolism2.04314836
17MP0001986_abnormal_taste_sensitivity2.02065944
18MP0004742_abnormal_vestibular_system1.96781002
19MP0006276_abnormal_autonomic_nervous1.92020672
20MP0009046_muscle_twitch1.89698501
21MP0005174_abnormal_tail_pigmentation1.88553307
22MP0005171_absent_coat_pigmentation1.86771258
23MP0002938_white_spotting1.83469606
24MP0002272_abnormal_nervous_system1.82240468
25MP0009745_abnormal_behavioral_response1.77909618
26MP0000566_synostosis1.75712379
27MP0004859_abnormal_synaptic_plasticity1.75620688
28MP0002102_abnormal_ear_morphology1.73722815
29MP0001968_abnormal_touch/_nociception1.72876995
30MP0004270_analgesia1.71436774
31MP0001188_hyperpigmentation1.71294450
32MP0004043_abnormal_pH_regulation1.70663518
33MP0000015_abnormal_ear_pigmentation1.69583891
34MP0002638_abnormal_pupillary_reflex1.69043779
35MP0001529_abnormal_vocalization1.67211141
36MP0003635_abnormal_synaptic_transmissio1.66664634
37MP0001346_abnormal_lacrimal_gland1.65549576
38MP0010678_abnormal_skin_adnexa1.65472918
39MP0004381_abnormal_hair_follicle1.64109320
40MP0003136_yellow_coat_color1.60730917
41MP0000427_abnormal_hair_cycle1.60223860
42MP0002277_abnormal_respiratory_mucosa1.57810611
43MP0005195_abnormal_posterior_eye1.57365092
44MP0002735_abnormal_chemical_nociception1.56123736
45MP0005248_abnormal_Harderian_gland1.56012796
46MP0003011_delayed_dark_adaptation1.54549116
47MP0002572_abnormal_emotion/affect_behav1.53497775
48MP0002064_seizures1.52480983
49MP0005391_vision/eye_phenotype1.52383069
50MP0002734_abnormal_mechanical_nocicepti1.51266110
51MP0002063_abnormal_learning/memory/cond1.50520404
52MP0000778_abnormal_nervous_system1.48462129
53MP0005187_abnormal_penis_morphology1.48099957
54MP0005645_abnormal_hypothalamus_physiol1.46351315
55MP0005386_behavior/neurological_phenoty1.46317902
56MP0004924_abnormal_behavior1.46317902
57MP0001324_abnormal_eye_pigmentation1.46140130
58MP0002184_abnormal_innervation1.45861467
59MP0008789_abnormal_olfactory_epithelium1.45062194
60MP0002557_abnormal_social/conspecific_i1.40799951
61MP0004142_abnormal_muscle_tone1.36018993
62MP0000955_abnormal_spinal_cord1.33767833
63MP0002067_abnormal_sensory_capabilities1.32996817
64MP0002009_preneoplasia1.32865779
65MP0001485_abnormal_pinna_reflex1.30860288
66MP0001502_abnormal_circadian_rhythm1.30465384
67MP0000462_abnormal_digestive_system1.30002888
68MP0005379_endocrine/exocrine_gland_phen1.29237602
69MP0002653_abnormal_ependyma_morphology1.29029727
70MP0004133_heterotaxia1.28728354
71MP0003195_calcinosis1.28073097
72MP0005387_immune_system_phenotype1.27913813
73MP0001790_abnormal_immune_system1.27913813
74MP0001970_abnormal_pain_threshold1.22954879
75MP0005310_abnormal_salivary_gland1.22653025
76MP0002095_abnormal_skin_pigmentation1.22228695
77MP0001879_abnormal_lymphatic_vessel1.21412546
78MP0001835_abnormal_antigen_presentation1.21358427
79MP0002736_abnormal_nociception_after1.20080288
80MP0002733_abnormal_thermal_nociception1.18926194
81MP0002837_dystrophic_cardiac_calcinosis1.17589993
82MP0000631_abnormal_neuroendocrine_gland1.15066969
83MP0000465_gastrointestinal_hemorrhage1.13229584
84MP0003121_genomic_imprinting1.12010994
85MP0003937_abnormal_limbs/digits/tail_de1.11483011
86MP0001501_abnormal_sleep_pattern1.08952034
87MP0003938_abnormal_ear_development1.08471305
88MP0002909_abnormal_adrenal_gland1.08278626
89MP0002234_abnormal_pharynx_morphology1.08094004
90MP0004885_abnormal_endolymph1.07877654
91MP0004145_abnormal_muscle_electrophysio1.07376876
92MP0008877_abnormal_DNA_methylation1.06821684
93MP0002177_abnormal_outer_ear1.06185592
94MP0002229_neurodegeneration1.05643957
95MP0001800_abnormal_humoral_immune1.05039820
96MP0003045_fibrosis1.03983203
97MP0003890_abnormal_embryonic-extraembry1.03977375
98MP0010386_abnormal_urinary_bladder1.03427947
99MP0003690_abnormal_glial_cell1.02390526
100MP0002877_abnormal_melanocyte_morpholog1.01936396
101MP0008995_early_reproductive_senescence1.01809432
102MP0002098_abnormal_vibrissa_morphology1.01518024
103MP0005499_abnormal_olfactory_system1.01022910
104MP0005394_taste/olfaction_phenotype1.01022910
105MP0002233_abnormal_nose_morphology1.00704499
106MP0002928_abnormal_bile_duct1.00265911
107MP0002163_abnormal_gland_morphology0.99207687
108MP0002452_abnormal_antigen_presenting0.99205274
109MP0000647_abnormal_sebaceous_gland0.98988980
110MP0005671_abnormal_response_to0.98678526
111MP0001851_eye_inflammation0.98642782
112MP0004811_abnormal_neuron_physiology0.97984894
113MP0002419_abnormal_innate_immunity0.97769521
114MP0002752_abnormal_somatic_nervous0.97724818
115MP0001486_abnormal_startle_reflex0.97407365
116MP0001984_abnormal_olfaction0.96614722
117MP0008058_abnormal_DNA_repair0.95927620
118MP0002152_abnormal_brain_morphology0.95306812
119MP0003633_abnormal_nervous_system0.93563792
120MP0000613_abnormal_salivary_gland0.89502335
121MP0002148_abnormal_hypersensitivity_rea0.88240747
122MP0004134_abnormal_chest_morphology0.86889888
123MP0003646_muscle_fatigue0.86447391
124MP0002723_abnormal_immune_serum0.86358838
125MP0005000_abnormal_immune_tolerance0.85122779
126MP0000579_abnormal_nail_morphology0.84130064
127MP0001299_abnormal_eye_distance/0.83910205
128MP0000026_abnormal_inner_ear0.83840169
129MP0002420_abnormal_adaptive_immunity0.83401643
130MP0001819_abnormal_immune_cell0.81774504
131MP0005075_abnormal_melanosome_morpholog0.81079272
132MP0001963_abnormal_hearing_physiology0.80309828
133MP0003634_abnormal_glial_cell0.79758505
134MP0003878_abnormal_ear_physiology0.79043136
135MP0005377_hearing/vestibular/ear_phenot0.79043136
136MP0001293_anophthalmia0.79038204
137MP0001440_abnormal_grooming_behavior0.78901107
138MP0003935_abnormal_craniofacial_develop0.78471205
139MP0004484_altered_response_of0.77066308
140MP0002396_abnormal_hematopoietic_system0.75421988
141MP0003755_abnormal_palate_morphology0.75368434
142MP0000049_abnormal_middle_ear0.75214579
143MP0001286_abnormal_eye_development0.75202331
144MP0003861_abnormal_nervous_system0.74298698
145MP0005025_abnormal_response_to0.74250620
146MP0000470_abnormal_stomach_morphology0.74152197
147MP0002882_abnormal_neuron_morphology0.71900902
148MP0003943_abnormal_hepatobiliary_system0.70463074
149MP0005646_abnormal_pituitary_gland0.69846209
150MP0002751_abnormal_autonomic_nervous0.69410549
151MP0009278_abnormal_bone_marrow0.68622920

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)4.17112472
2Congenital stationary night blindness (HP:0007642)4.09083973
3Pancreatic cysts (HP:0001737)4.04309685
4True hermaphroditism (HP:0010459)3.69037006
5Pancreatic fibrosis (HP:0100732)3.68407943
6Lip pit (HP:0100267)3.46450338
7Bony spicule pigmentary retinopathy (HP:0007737)3.41822894
8Broad-based gait (HP:0002136)3.35964281
9Dyschromatopsia (HP:0007641)3.33768493
10Absent rod-and cone-mediated responses on ERG (HP:0007688)3.32950256
11Abnormality of macular pigmentation (HP:0008002)3.25895264
12Abnormal rod and cone electroretinograms (HP:0008323)3.25667723
13Decreased central vision (HP:0007663)3.15483752
14Volvulus (HP:0002580)3.03769092
15Central scotoma (HP:0000603)3.00684480
16Progressive cerebellar ataxia (HP:0002073)2.99407140
17Gait imbalance (HP:0002141)2.99177651
18Drooling (HP:0002307)2.98152529
19Febrile seizures (HP:0002373)2.95746722
20Keratoconus (HP:0000563)2.84599406
21Increased corneal curvature (HP:0100692)2.84599406
22Parakeratosis (HP:0001036)2.83400645
23Genetic anticipation (HP:0003743)2.83397948
24Congenital sensorineural hearing impairment (HP:0008527)2.81692208
25White forelock (HP:0002211)2.79611827
26Congenital primary aphakia (HP:0007707)2.76890719
27Excessive salivation (HP:0003781)2.74016033
28Oligodactyly (hands) (HP:0001180)2.73997461
29Patchy hypopigmentation of hair (HP:0011365)2.71450545
30Abnormality of the renal cortex (HP:0011035)2.67586260
31Attenuation of retinal blood vessels (HP:0007843)2.62878609
32Degeneration of the lateral corticospinal tracts (HP:0002314)2.62221405
33Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.62221405
34Gaze-evoked nystagmus (HP:0000640)2.60988011
35Abolished electroretinogram (ERG) (HP:0000550)2.59874575
36Abnormality of the fingertips (HP:0001211)2.59362189
37Hepatoblastoma (HP:0002884)2.58383173
38Genital tract atresia (HP:0001827)2.57673768
39Type II lissencephaly (HP:0007260)2.56449631
40Cystic liver disease (HP:0006706)2.55017438
41Focal motor seizures (HP:0011153)2.54875100
42Cone-rod dystrophy (HP:0000548)2.54342557
43Abnormality of the labia minora (HP:0012880)2.51861874
44Nephrogenic diabetes insipidus (HP:0009806)2.50546448
45Focal seizures (HP:0007359)2.46583529
46Pendular nystagmus (HP:0012043)2.43072119
47Lissencephaly (HP:0001339)2.42536976
48Stomach cancer (HP:0012126)2.39357241
49Abnormality of the renal collecting system (HP:0004742)2.38831012
50Cupped ear (HP:0000378)2.37713089
51Septo-optic dysplasia (HP:0100842)2.36961198
52Polyphagia (HP:0002591)2.36911331
53Protruding tongue (HP:0010808)2.36464203
54Submucous cleft hard palate (HP:0000176)2.34180281
55Dynein arm defect of respiratory motile cilia (HP:0012255)2.33339054
56Absent/shortened dynein arms (HP:0200106)2.33339054
57Recurrent abscess formation (HP:0002722)2.31378237
58Abnormality of the nasal septum (HP:0000419)2.30861085
59Thyroiditis (HP:0100646)2.30215749
60Absent speech (HP:0001344)2.29246520
61Agitation (HP:0000713)2.27551305
62Poor coordination (HP:0002370)2.21353780
63Scotoma (HP:0000575)2.18625571
64Pachygyria (HP:0001302)2.18096324
65Recurrent bacterial skin infections (HP:0005406)2.15181264
66Postaxial hand polydactyly (HP:0001162)2.15073608
67Aplasia/Hypoplasia of the tongue (HP:0010295)2.15000887
68Inability to walk (HP:0002540)2.14902443
69Midline defect of the nose (HP:0004122)2.13227361
70Renal cortical cysts (HP:0000803)2.13147080
71Widely spaced teeth (HP:0000687)2.12389714
72Postaxial foot polydactyly (HP:0001830)2.12314729
73Congenital hepatic fibrosis (HP:0002612)2.11987267
74Chromosomal breakage induced by crosslinking agents (HP:0003221)2.11791017
75Alacrima (HP:0000522)2.10863976
76Decreased lacrimation (HP:0000633)2.10491084
77Chorioretinal atrophy (HP:0000533)2.09281813
78Abnormality of incisor morphology (HP:0011063)2.09192386
79Aplasia cutis congenita (HP:0001057)2.09044639
80Agammaglobulinemia (HP:0004432)2.08498026
81Pigmentary retinal degeneration (HP:0001146)2.08061294
82Hemiparesis (HP:0001269)2.06582449
83Ectopic kidney (HP:0000086)2.04916862
84Anencephaly (HP:0002323)2.03606648
85Anteriorly placed anus (HP:0001545)2.03287599
86Chromsome breakage (HP:0040012)2.03224041
87Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.02662152
88Short 4th metacarpal (HP:0010044)2.02662152
89Specific learning disability (HP:0001328)2.02423213
90Duplicated collecting system (HP:0000081)2.01611659
91Photophobia (HP:0000613)2.01403022
92Atonic seizures (HP:0010819)2.01391575
93Aplasia/Hypoplasia of the tibia (HP:0005772)2.01336140
94Dialeptic seizures (HP:0011146)1.98590834
95Cerebellar dysplasia (HP:0007033)1.98469153
96Anophthalmia (HP:0000528)1.98068514
97Hip dysplasia (HP:0001385)1.93804574
98Abnormality of the fovea (HP:0000493)1.90837243
99Colon cancer (HP:0003003)1.88461981
100Amyotrophic lateral sclerosis (HP:0007354)1.87384784
101Intestinal atresia (HP:0011100)1.86879290
102Fair hair (HP:0002286)1.86717842
103Renal hypoplasia (HP:0000089)1.86127161
104Progressive inability to walk (HP:0002505)1.86048279
105Narrow forehead (HP:0000341)1.85558431
106Labial hypoplasia (HP:0000066)1.85281337
107Abnormality of the corticospinal tract (HP:0002492)1.85130710
108Sclerocornea (HP:0000647)1.84937643
109Tented upper lip vermilion (HP:0010804)1.84883788
110Oligodactyly (HP:0012165)1.84680949
111Tubulointerstitial nephritis (HP:0001970)1.84375004
112Neoplasm of the oral cavity (HP:0100649)1.83188630
113Absent septum pellucidum (HP:0001331)1.82571248
114Male pseudohermaphroditism (HP:0000037)1.81735164
115Growth hormone deficiency (HP:0000824)1.81616813
116Thyroid-stimulating hormone excess (HP:0002925)1.81497636
117Hypoplastic ischia (HP:0003175)1.80591067
118Hypoplasia of the fovea (HP:0007750)1.80163936
119Aplasia/Hypoplasia of the fovea (HP:0008060)1.80163936
120Abnormal hair whorl (HP:0010721)1.80094458
121Severe visual impairment (HP:0001141)1.80018194
122Short foot (HP:0001773)1.79897765
123Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.79519100
124Abnormality of the renal medulla (HP:0100957)1.79429758
125Eczematoid dermatitis (HP:0000976)1.78720287
126Tubular atrophy (HP:0000092)1.78471002
127Abnormal respiratory epithelium morphology (HP:0012253)1.78194373
128Abnormal respiratory motile cilium morphology (HP:0005938)1.78194373
129Macular degeneration (HP:0000608)1.77880457
130Recurrent pneumonia (HP:0006532)1.77590413
131Exotropia (HP:0000577)1.77562276
132Macroorchidism (HP:0000053)1.77490140
133Abnormal ciliary motility (HP:0012262)1.75598527
134Prostate neoplasm (HP:0100787)1.75424600
135Abnormality of the ischium (HP:0003174)1.74742857
136Ectropion (HP:0000656)1.73640633
137Osteomalacia (HP:0002749)1.72166425
138Type II diabetes mellitus (HP:0005978)1.70827289
139Abnormality of the septum pellucidum (HP:0007375)1.69547128
140Aqueductal stenosis (HP:0002410)1.68495601
141Chronic hepatic failure (HP:0100626)1.68095346
142Recurrent skin infections (HP:0001581)1.67226792
143Medial flaring of the eyebrow (HP:0010747)1.64321327
144Optic nerve hypoplasia (HP:0000609)1.63497950
145Abnormality of the columella (HP:0009929)1.62706085
146Long eyelashes (HP:0000527)1.62121737
147Retinitis pigmentosa (HP:0000510)1.61729811
148Hypoplastic labia majora (HP:0000059)1.61709960
149Abnormality of DNA repair (HP:0003254)1.60951581
150Nephronophthisis (HP:0000090)1.60499893
151Nasolacrimal duct obstruction (HP:0000579)1.58331029
152Recurrent fungal infections (HP:0002841)1.58318293
153Abnormality of the nasolacrimal system (HP:0000614)1.55951007
154Recurrent cutaneous fungal infections (HP:0011370)1.55562254
155Chronic mucocutaneous candidiasis (HP:0002728)1.55562254
156Abnormality of the parathyroid morphology (HP:0011766)1.54746072
157Asymmetry of the thorax (HP:0001555)1.54659637
158Abnormality of the frontal sinuses (HP:0002687)1.53477509
159Abnormality of the parietal bone (HP:0002696)1.53397522
160Morphological abnormality of the middle ear (HP:0008609)1.53009783
161Chin dimple (HP:0010751)1.52969824
162Molar tooth sign on MRI (HP:0002419)1.52592094
163Abnormality of midbrain morphology (HP:0002418)1.52592094
164Slow saccadic eye movements (HP:0000514)1.52249400
165Obstructive lung disease (HP:0006536)1.52080982
166Chronic obstructive pulmonary disease (HP:0006510)1.52080982
167Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.51989596
168Pulmonary artery stenosis (HP:0004415)1.50657196
169Gastrointestinal stroma tumor (HP:0100723)1.50584397
170Papillary thyroid carcinoma (HP:0002895)1.50482117
171Vaginal atresia (HP:0000148)1.50010280
172Anal stenosis (HP:0002025)1.49378659

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR3.04399330
2MAP3K42.98890306
3TNIK2.75326739
4WNK32.72509334
5MARK12.70876142
6STK392.45239850
7IRAK42.45160304
8EPHB12.44664363
9BRD42.35476910
10NUAK12.31314769
11MAP4K22.27522670
12MAP2K71.91935547
13PBK1.84444059
14NTRK21.83547827
15PINK11.82774180
16MAP3K141.72445345
17CAMK1G1.70567628
18PAK31.65635944
19MAPK151.65062103
20ACVR1B1.62952111
21IRAK31.62010378
22TAOK31.60408135
23NTRK31.60246888
24PKN11.59961215
25PRPF4B1.58806053
26YES11.58412239
27OXSR11.57748589
28GRK11.53052922
29BMPR1B1.50104486
30HIPK21.47999556
31WNK11.43362856
32CAMK1D1.40308203
33NEK61.38969035
34BCR1.35976906
35PNCK1.34345876
36EPHA41.32282988
37ERBB31.29716478
38FGFR21.24837751
39CASK1.23824809
40MKNK21.23675398
41TRPM71.22648328
42EPHA31.21325373
43CLK11.20661842
44CDK121.17361698
45IRAK21.14222251
46DAPK21.07243416
47CSNK1A1L1.06633680
48TEC1.06081895
49ZAK1.05082101
50MKNK11.04144948
51CDK31.03756912
52FRK1.02876258
53STK41.02412142
54STK38L0.97980898
55ICK0.96710227
56SGK2230.95279373
57SGK4940.95279373
58MAP2K40.94376973
59AKT30.93523518
60MAPK130.93174869
61CAMKK20.92831628
62PLK20.91759990
63CHUK0.90604820
64DYRK30.89720576
65BLK0.89712128
66IKBKB0.89608367
67SRPK10.89396431
68MARK20.89275445
69CSNK1G20.87980226
70IRAK10.87783335
71EIF2AK20.87322707
72IKBKE0.87315498
73SIK20.85767304
74ERBB20.85657135
75ADRBK10.85279912
76PRKCE0.83597193
77CDK190.83521891
78KIT0.83081644
79BMPR20.82848660
80STK110.82578338
81CSK0.81173361
82DMPK0.80258081
83PRKCG0.79350742
84RPS6KA50.78751545
85FGR0.78370622
86BTK0.78310132
87CDK90.77827710
88UHMK10.77287220
89ITK0.76692694
90TLK10.76281808
91SGK20.75803078
92ADRBK20.74474563
93OBSCN0.74005083
94GRK70.73181159
95CSF1R0.72033203
96PIK3CA0.69057336
97RIPK40.68775875
98TXK0.67281615
99TIE10.66924224
100MST40.65330831
101CAMK2A0.64293827
102DYRK1B0.64104405
103MAP3K60.63036018
104PDGFRB0.62090086
105WNK40.61386377
106DYRK20.61202937
107PRKAA20.60878841
108PRKCQ0.60688281
109STK30.60604947
110MAP3K130.60437578
111CSNK1G10.60239677
112NLK0.60073118
113CAMK40.58842281
114LATS10.56544325
115PRKG10.56184436
116JAK10.54862759
117LCK0.54788108
118STK160.54781450
119TGFBR10.54692144
120CAMK10.54644421
121FES0.54477326
122CSNK1G30.54057409
123LYN0.54020556
124MINK10.53187674
125DYRK1A0.53148188
126SIK30.52778195
127SGK30.52678346
128PRKCZ0.50949911
129PTK2B0.50059862
130CDC42BPA0.49925491
131HCK0.48934535
132CDK50.48025476
133SGK10.47965219
134SYK0.46391075
135PIK3CG0.46186998
136MAPKAPK50.45856449
137PRKACA0.45023226
138PRKD20.44479578
139MAPK70.43496387
140MAP4K10.42883447
141PRKACB0.42539150
142MAP3K70.40216954
143CSNK1A10.38569106
144TGFBR20.37957045
145TNK20.35820377
146BRSK20.34671251
147CSNK1D0.34647598
148PLK40.32887731
149FER0.32157672

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.56953569
2Nicotine addiction_Homo sapiens_hsa050333.27235901
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.10106184
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.01527152
5Circadian entrainment_Homo sapiens_hsa047132.01222899
6Butanoate metabolism_Homo sapiens_hsa006501.99695965
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.96103708
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.95485225
9GABAergic synapse_Homo sapiens_hsa047271.87506858
10Non-homologous end-joining_Homo sapiens_hsa034501.80317947
11Regulation of autophagy_Homo sapiens_hsa041401.72457560
12Insulin secretion_Homo sapiens_hsa049111.72003537
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.65848842
14Dopaminergic synapse_Homo sapiens_hsa047281.61572313
15Olfactory transduction_Homo sapiens_hsa047401.55604098
16Sphingolipid metabolism_Homo sapiens_hsa006001.54972558
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.53730701
18Ether lipid metabolism_Homo sapiens_hsa005651.52276805
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42285742
20B cell receptor signaling pathway_Homo sapiens_hsa046621.41694939
21Nitrogen metabolism_Homo sapiens_hsa009101.41167945
22Transcriptional misregulation in cancer_Homo sapiens_hsa052021.38792389
23Renin secretion_Homo sapiens_hsa049241.37211467
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.34031418
25Cocaine addiction_Homo sapiens_hsa050301.33962507
26Salivary secretion_Homo sapiens_hsa049701.32564037
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.30517023
28Steroid biosynthesis_Homo sapiens_hsa001001.25346961
29Protein export_Homo sapiens_hsa030601.22622714
30Primary immunodeficiency_Homo sapiens_hsa053401.22431357
31Fanconi anemia pathway_Homo sapiens_hsa034601.21526169
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.20518110
33Hematopoietic cell lineage_Homo sapiens_hsa046401.20218269
34Axon guidance_Homo sapiens_hsa043601.19713005
35Long-term depression_Homo sapiens_hsa047301.12802627
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.12128719
37Tryptophan metabolism_Homo sapiens_hsa003801.09934269
38Propanoate metabolism_Homo sapiens_hsa006401.08819843
39Chemokine signaling pathway_Homo sapiens_hsa040621.07958973
40Notch signaling pathway_Homo sapiens_hsa043301.07638528
41Amphetamine addiction_Homo sapiens_hsa050311.07248079
42Leishmaniasis_Homo sapiens_hsa051401.05288314
43Calcium signaling pathway_Homo sapiens_hsa040201.04131703
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01982372
45Osteoclast differentiation_Homo sapiens_hsa043801.01163872
46Autoimmune thyroid disease_Homo sapiens_hsa053201.00467059
47Circadian rhythm_Homo sapiens_hsa047100.96834979
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96638335
49Toll-like receptor signaling pathway_Homo sapiens_hsa046200.96613540
50Serotonergic synapse_Homo sapiens_hsa047260.95626381
51Primary bile acid biosynthesis_Homo sapiens_hsa001200.94825387
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94795105
53Prostate cancer_Homo sapiens_hsa052150.94779069
54Lysine degradation_Homo sapiens_hsa003100.93271842
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93149517
56Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93002139
57Malaria_Homo sapiens_hsa051440.92955167
58Oxytocin signaling pathway_Homo sapiens_hsa049210.92461083
59Measles_Homo sapiens_hsa051620.91212507
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.90786008
61Gastric acid secretion_Homo sapiens_hsa049710.90701081
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.88675328
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88595963
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88436744
65Dorso-ventral axis formation_Homo sapiens_hsa043200.87734908
66Caffeine metabolism_Homo sapiens_hsa002320.87488653
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.86414212
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86281435
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.85424269
70Linoleic acid metabolism_Homo sapiens_hsa005910.84695543
71Type II diabetes mellitus_Homo sapiens_hsa049300.84427903
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84262045
73TNF signaling pathway_Homo sapiens_hsa046680.83051169
74ABC transporters_Homo sapiens_hsa020100.82953780
75Arachidonic acid metabolism_Homo sapiens_hsa005900.80721039
76Allograft rejection_Homo sapiens_hsa053300.80500185
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80169443
78Herpes simplex infection_Homo sapiens_hsa051680.79871424
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78776015
80Rheumatoid arthritis_Homo sapiens_hsa053230.78273512
81Inositol phosphate metabolism_Homo sapiens_hsa005620.77753846
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77436275
83Graft-versus-host disease_Homo sapiens_hsa053320.77179977
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75560021
85T cell receptor signaling pathway_Homo sapiens_hsa046600.74938621
86MicroRNAs in cancer_Homo sapiens_hsa052060.74915614
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74821278
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74583222
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.74294052
90Hepatitis C_Homo sapiens_hsa051600.74125519
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73653152
92Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73639530
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73457280
94Ovarian steroidogenesis_Homo sapiens_hsa049130.73319352
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72754285
96Platelet activation_Homo sapiens_hsa046110.72609820
97Basal transcription factors_Homo sapiens_hsa030220.72524053
98Asthma_Homo sapiens_hsa053100.71909319
99Peroxisome_Homo sapiens_hsa041460.71879783
100Renal cell carcinoma_Homo sapiens_hsa052110.70711735
101Ras signaling pathway_Homo sapiens_hsa040140.70465140
102Other glycan degradation_Homo sapiens_hsa005110.70187079
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68193169
104MAPK signaling pathway_Homo sapiens_hsa040100.67960137
105Influenza A_Homo sapiens_hsa051640.67313192
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66508047
107Retinol metabolism_Homo sapiens_hsa008300.65315083
108Pancreatic secretion_Homo sapiens_hsa049720.65170936
109Wnt signaling pathway_Homo sapiens_hsa043100.65115036
110Toxoplasmosis_Homo sapiens_hsa051450.64288063
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64284846
112Morphine addiction_Homo sapiens_hsa050320.64138740
113Choline metabolism in cancer_Homo sapiens_hsa052310.62337219
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.62259251
115Chemical carcinogenesis_Homo sapiens_hsa052040.61350499
116Chronic myeloid leukemia_Homo sapiens_hsa052200.61243014
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60768160
118beta-Alanine metabolism_Homo sapiens_hsa004100.60765113
119Cholinergic synapse_Homo sapiens_hsa047250.60521865
120ErbB signaling pathway_Homo sapiens_hsa040120.60075167
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.59420586
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59099610
123Glycerolipid metabolism_Homo sapiens_hsa005610.58543606
124Pathways in cancer_Homo sapiens_hsa052000.57985444
125Phagosome_Homo sapiens_hsa041450.57901385
126Taste transduction_Homo sapiens_hsa047420.57676089
127Homologous recombination_Homo sapiens_hsa034400.57179088
128Tuberculosis_Homo sapiens_hsa051520.56842777
129Basal cell carcinoma_Homo sapiens_hsa052170.56663164
130Salmonella infection_Homo sapiens_hsa051320.55823374
131Histidine metabolism_Homo sapiens_hsa003400.55815537
132Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55484218
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55475978
134Acute myeloid leukemia_Homo sapiens_hsa052210.54855965
135PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53785298
136Pancreatic cancer_Homo sapiens_hsa052120.53228708
137FoxO signaling pathway_Homo sapiens_hsa040680.51952896
138cAMP signaling pathway_Homo sapiens_hsa040240.51109539
139Glutamatergic synapse_Homo sapiens_hsa047240.49871909
140Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49514441
141mRNA surveillance pathway_Homo sapiens_hsa030150.49360496
142Shigellosis_Homo sapiens_hsa051310.48952197
143Hedgehog signaling pathway_Homo sapiens_hsa043400.48666780
144Gap junction_Homo sapiens_hsa045400.48601639
145Hepatitis B_Homo sapiens_hsa051610.48312073
146Cardiac muscle contraction_Homo sapiens_hsa042600.48295545
147RNA degradation_Homo sapiens_hsa030180.48268076
148Glycerophospholipid metabolism_Homo sapiens_hsa005640.46277221
149Prolactin signaling pathway_Homo sapiens_hsa049170.45268746
150Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44863946
151Collecting duct acid secretion_Homo sapiens_hsa049660.44380843
152Alcoholism_Homo sapiens_hsa050340.43462738
153Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42934814
154Hippo signaling pathway_Homo sapiens_hsa043900.42780973
155Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41795680
156Synaptic vesicle cycle_Homo sapiens_hsa047210.40932758
157Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39507038
158Rap1 signaling pathway_Homo sapiens_hsa040150.36207667
159TGF-beta signaling pathway_Homo sapiens_hsa043500.35259726
160Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33820338

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