BBC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)5.96405836
2embryonic process involved in female pregnancy (GO:0060136)5.62174316
3establishment of apical/basal cell polarity (GO:0035089)4.64857033
4transcription from mitochondrial promoter (GO:0006390)4.63622490
5negative regulation of erythrocyte differentiation (GO:0045647)4.56092013
6regulation of gene silencing by RNA (GO:0060966)4.40059427
7regulation of posttranscriptional gene silencing (GO:0060147)4.40059427
8regulation of gene silencing by miRNA (GO:0060964)4.40059427
9regulation of translational fidelity (GO:0006450)4.31165912
10positive regulation by symbiont of host defense response (GO:0052509)4.29726046
11modulation by symbiont of host defense response (GO:0052031)4.29726046
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.29726046
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.29726046
14positive regulation by organism of defense response of other organism involved in symbiotic interact4.29726046
15modulation by symbiont of host immune response (GO:0052553)4.29726046
16regulation of integrin activation (GO:0033623)4.10225231
17formation of translation preinitiation complex (GO:0001731)4.07465862
18proline metabolic process (GO:0006560)4.06127895
19modulation by virus of host process (GO:0019054)4.03166022
20replication fork processing (GO:0031297)4.00835215
21establishment of monopolar cell polarity (GO:0061162)4.00429569
22establishment or maintenance of monopolar cell polarity (GO:0061339)4.00429569
23modulation by symbiont of host cellular process (GO:0044068)3.95616401
24DNA deamination (GO:0045006)3.94017165
25histone H4-K12 acetylation (GO:0043983)3.88416260
26mitochondrial DNA metabolic process (GO:0032042)3.84203325
27dosage compensation (GO:0007549)3.82759513
28mitotic G1 DNA damage checkpoint (GO:0031571)3.80356528
29regulation of chromatin binding (GO:0035561)3.68248128
30trophectodermal cell differentiation (GO:0001829)3.68021868
31pre-miRNA processing (GO:0031054)3.66820031
32cellular response to virus (GO:0098586)3.66190475
33embryonic placenta development (GO:0001892)3.64608884
34heterochromatin organization (GO:0070828)3.62445951
35apoptotic process involved in morphogenesis (GO:0060561)3.60512805
36protein localization to kinetochore (GO:0034501)3.57249074
37protein localization to endosome (GO:0036010)3.55862521
38maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.54031852
39somatic hypermutation of immunoglobulin genes (GO:0016446)3.51675433
40somatic diversification of immune receptors via somatic mutation (GO:0002566)3.51675433
41activation of MAPKKK activity (GO:0000185)3.51319816
42folic acid-containing compound biosynthetic process (GO:0009396)3.51224113
43nodal signaling pathway (GO:0038092)3.50190153
44negative regulation of cAMP-mediated signaling (GO:0043951)3.44550036
45response to peptidoglycan (GO:0032494)3.44496173
46response to muramyl dipeptide (GO:0032495)3.44392640
47mitotic G1/S transition checkpoint (GO:0044819)3.42332855
48negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.36674808
49NIK/NF-kappaB signaling (GO:0038061)3.36303195
50maternal placenta development (GO:0001893)3.34820542
51positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.33220813
52ribosomal small subunit biogenesis (GO:0042274)3.31774078
53regulation of early endosome to late endosome transport (GO:2000641)3.31093699
54mannose metabolic process (GO:0006013)3.28441083
55mitotic sister chromatid segregation (GO:0000070)3.26975298
56negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.26388193
57negative regulation of cell killing (GO:0031342)3.26388193
58regulation of mammary gland epithelial cell proliferation (GO:0033599)3.25339360
59oxygen transport (GO:0015671)3.24942487
60erythrocyte maturation (GO:0043249)3.22080435
61regulation of hippo signaling (GO:0035330)3.16716449
62mRNA cleavage (GO:0006379)3.15205849
63G1 DNA damage checkpoint (GO:0044783)3.11399919
64negative regulation of cell cycle arrest (GO:0071157)3.09784207
65macrophage activation involved in immune response (GO:0002281)3.08873439
66intracellular estrogen receptor signaling pathway (GO:0030520)3.07082271
67erythrocyte development (GO:0048821)3.06343296
68protoporphyrinogen IX metabolic process (GO:0046501)3.03564733
69positive regulation of Cdc42 GTPase activity (GO:0043089)2.99949008
70positive regulation of histone deacetylation (GO:0031065)2.96413650
71granulocyte differentiation (GO:0030851)2.92315230
72oxidative demethylation (GO:0070989)2.91141301
73negative regulation of mRNA processing (GO:0050686)2.91037028
74negative regulation of fatty acid biosynthetic process (GO:0045717)2.90791132
75spliceosomal tri-snRNP complex assembly (GO:0000244)2.90105494
76protein localization to chromosome, centromeric region (GO:0071459)2.90062218
77DNA unwinding involved in DNA replication (GO:0006268)2.89450022
78chromatin assembly (GO:0031497)2.89221635
79positive regulation by host of viral transcription (GO:0043923)2.89006409
80viral transcription (GO:0019083)2.86610440
81mitotic nuclear envelope disassembly (GO:0007077)2.84613157
82sister chromatid segregation (GO:0000819)2.84186506
83telomere maintenance via semi-conservative replication (GO:0032201)2.82399260
84negative regulation of RNA splicing (GO:0033119)2.82398487
85polarized epithelial cell differentiation (GO:0030859)2.82323782
86intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.79606107
87* regulation of protein homooligomerization (GO:0032462)2.78449824
88base-excision repair (GO:0006284)2.77119081
89positive regulation of protein deacetylation (GO:0090312)2.76727542
90* intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.74590938
91antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.72290864
92negative regulation of JAK-STAT cascade (GO:0046426)2.72109697
93regulation of RNA export from nucleus (GO:0046831)2.72031365
94regulation of apoptotic process involved in morphogenesis (GO:1902337)2.72021338
95negative regulation of viral release from host cell (GO:1902187)2.71250730
96negative regulation of toll-like receptor signaling pathway (GO:0034122)2.71239750
97DNA strand elongation involved in DNA replication (GO:0006271)2.70180665
98histone H4 deacetylation (GO:0070933)2.70059782
99membrane disassembly (GO:0030397)2.69318759
100nuclear envelope disassembly (GO:0051081)2.69318759
101viral protein processing (GO:0019082)2.68609517
102regulation of interferon-beta biosynthetic process (GO:0045357)2.68124670
103negative regulation of interleukin-12 production (GO:0032695)2.68010488
104DNA duplex unwinding (GO:0032508)2.67717358
105DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.66755213
106positive regulation of developmental pigmentation (GO:0048087)2.65561268
107histone H4-K5 acetylation (GO:0043981)2.65471202
108histone H4-K8 acetylation (GO:0043982)2.65471202
109* positive regulation of protein homooligomerization (GO:0032464)2.64813633
110detection of other organism (GO:0098543)2.64720240
111ribosome biogenesis (GO:0042254)2.64433976
112DNA geometric change (GO:0032392)2.64320582
113regulation of sister chromatid cohesion (GO:0007063)2.64011914
114germinal center formation (GO:0002467)2.63819693
115developmental programmed cell death (GO:0010623)2.63262057
116positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.62175563
117positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.62175563
118positive regulation of mitotic sister chromatid separation (GO:1901970)2.62175563
119termination of RNA polymerase II transcription (GO:0006369)2.61295211
120planar cell polarity pathway involved in neural tube closure (GO:0090179)2.61076888
121positive regulation of gamma-delta T cell activation (GO:0046645)2.60200198
122* positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.59241605
123neutrophil activation involved in immune response (GO:0002283)2.58947889
124negative regulation of DNA-templated transcription, elongation (GO:0032785)2.58715529
125protein insertion into membrane (GO:0051205)2.58285479
126detection of bacterium (GO:0016045)2.57708956
127regulation of gene silencing (GO:0060968)2.56902291
128virion assembly (GO:0019068)2.56794475
1293-UTR-mediated mRNA stabilization (GO:0070935)2.55160615
130stress fiber assembly (GO:0043149)2.54828186
131negative regulation of mRNA metabolic process (GO:1903312)2.54779326
132apoptotic process involved in development (GO:1902742)2.54711166
133DNA strand elongation (GO:0022616)2.54221654
134histone arginine methylation (GO:0034969)2.53858052
135DNA damage response, signal transduction resulting in transcription (GO:0042772)2.53098293
136positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.52822612
137tooth mineralization (GO:0034505)2.52728233
138gas transport (GO:0015669)2.52518334
139DNA strand renaturation (GO:0000733)2.52452735
140negative regulation of protein oligomerization (GO:0032460)2.52424631
141positive regulation of SMAD protein import into nucleus (GO:0060391)2.52257027
142response to laminar fluid shear stress (GO:0034616)2.51721856
143antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.51461285
144regulation of ARF GTPase activity (GO:0032312)2.51083731
145antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.48586183
146retinoic acid receptor signaling pathway (GO:0048384)2.48561240
147positive thymic T cell selection (GO:0045059)2.47740118
148regulation of mast cell degranulation (GO:0043304)2.47360841
149regulation of double-strand break repair (GO:2000779)2.47315057
150glutamine family amino acid biosynthetic process (GO:0009084)2.47120144
151negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.47094220
152positive regulation of receptor recycling (GO:0001921)2.45066410
153positive regulation of chromosome segregation (GO:0051984)2.44954784
154peptidyl-arginine omega-N-methylation (GO:0035247)2.44423005
155lipopolysaccharide-mediated signaling pathway (GO:0031663)2.43714789
156regulation of NFAT protein import into nucleus (GO:0051532)2.43638719
157regulation of T-helper 2 cell differentiation (GO:0045628)2.43402094
158pteridine-containing compound biosynthetic process (GO:0042559)2.43156780
159translational termination (GO:0006415)2.42869354
160cell-cell junction maintenance (GO:0045217)2.42494414
161cell migration in hindbrain (GO:0021535)2.42307790
162thymic T cell selection (GO:0045061)2.42203714
163respiratory system process (GO:0003016)2.41573255
164mitochondrial RNA metabolic process (GO:0000959)2.41468649
165antigen processing and presentation of endogenous antigen (GO:0019883)2.41455576
166mRNA stabilization (GO:0048255)2.40824049
167RNA stabilization (GO:0043489)2.40824049
168spindle assembly (GO:0051225)2.40723204
169negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.40717365
170regulation of response to osmotic stress (GO:0047484)2.40336374
171vagina development (GO:0060068)2.40114405
172viral mRNA export from host cell nucleus (GO:0046784)2.40005885
173intrinsic apoptotic signaling pathway by p53 class mediator (GO:0072332)2.39212326
174negative regulation of granulocyte differentiation (GO:0030853)2.38691000
175regulation of protein heterodimerization activity (GO:0043497)2.38308830
176myeloid dendritic cell differentiation (GO:0043011)2.38123882
177tolerance induction (GO:0002507)2.36964790
178response to host immune response (GO:0052572)2.36099387
179response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.36099387
180positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.35520924
181regulation of leukocyte degranulation (GO:0043300)2.35225323
182modulation by virus of host morphology or physiology (GO:0019048)2.34571910
183* negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.32420614
184activation of Rac GTPase activity (GO:0032863)2.32024776
185adherens junction assembly (GO:0034333)2.31870421
186negative regulation of glial cell proliferation (GO:0060253)2.31522596
187negative regulation of necroptotic process (GO:0060546)2.31448197
188regulation of defense response to virus by virus (GO:0050690)2.31257888
189response to host defenses (GO:0052200)2.30901375
190response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.30901375

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.39185585
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.86982290
3MYC_22102868_ChIP-Seq_BL_Human2.79040191
4SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.72636328
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.69056691
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.58290416
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.58290416
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.58290416
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.55052488
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.40577814
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.37428886
12VDR_21846776_ChIP-Seq_THP-1_Human2.33929146
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.25339682
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.25120205
15ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.12006704
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.10112373
17* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.04136211
18* KDM2B_26808549_Chip-Seq_K562_Human2.01708641
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.91274736
20POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.89059761
21KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.86426183
22* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.82652960
23NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.78316670
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.78196709
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77716584
26* KDM2B_26808549_Chip-Seq_JURKAT_Human1.73966140
27P68_20966046_ChIP-Seq_HELA_Human1.73809569
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.71833859
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.71763097
30* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70131705
31* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.69067989
32SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.68641438
33CTCF_27219007_Chip-Seq_ERYTHROID_Human1.66564139
34SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.65210025
35SA1_27219007_Chip-Seq_ERYTHROID_Human1.65112829
36E2F4_17652178_ChIP-ChIP_JURKAT_Human1.63781744
37TCF3_18692474_ChIP-Seq_MEFs_Mouse1.59973830
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.58694891
39* TCF7_22412390_ChIP-Seq_EML_Mouse1.58613357
40DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.58537051
41ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.57027406
42* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54012906
43* ELK3_25401928_ChIP-Seq_HUVEC_Human1.54004447
44UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.52360664
45NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.51747913
46* KDM2B_26808549_Chip-Seq_DND41_Human1.51403031
47* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.48408013
48* LXR_22292898_ChIP-Seq_THP-1_Human1.47071520
49ELF1_20517297_ChIP-Seq_JURKAT_Human1.46685885
50TCF3_18692474_ChIP-Seq_MESCs_Mouse1.45697229
51* TP53_22127205_ChIP-Seq_IMR90_Human1.45690175
52* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45219656
53* CREB1_26743006_Chip-Seq_LNCaP_Human1.43531321
54KLF4_18555785_ChIP-Seq_MESCs_Mouse1.43245740
55* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.41485496
56ZNF263_19887448_ChIP-Seq_K562_Human1.41414552
57MAF_26560356_Chip-Seq_TH1_Human1.40996290
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.38731673
59XRN2_22483619_ChIP-Seq_HELA_Human1.36033007
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.35505216
61CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.34718448
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33089283
63BCL6_27268052_Chip-Seq_Bcells_Human1.31779162
64CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31663456
65BCOR_27268052_Chip-Seq_Bcells_Human1.30750336
66SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.30734718
67GATA1_19941826_ChIP-Seq_K562_Human1.30204225
68NANOG_21062744_ChIP-ChIP_HESCs_Human1.29626492
69ERG_21242973_ChIP-ChIP_JURKAT_Human1.29382299
70HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.28606085
71POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.28001160
72SMC4_20622854_ChIP-Seq_HELA_Human1.26550869
73NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26457498
74RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.24517222
75GATA1_19941827_ChIP-Seq_MEL_Mouse1.24174655
76TFEB_21752829_ChIP-Seq_HELA_Human1.23844406
77E2F1_18555785_ChIP-Seq_MESCs_Mouse1.23614132
78ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23377007
79RACK7_27058665_Chip-Seq_MCF-7_Human1.21927260
80POU5F1_16518401_ChIP-PET_MESCs_Mouse1.21411641
81* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20261375
82SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19846537
83TP63_17297297_ChIP-ChIP_HaCaT_Human1.19589838
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18220243
85MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.17615564
86* UTX_26944678_Chip-Seq_JUKART_Human1.17603833
87NCOR1_26117541_ChIP-Seq_K562_Human1.17329869
88KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16609728
89NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.16515564
90SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16260404
91MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14149878
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13836513
93* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.13695590
94KDM5A_27292631_Chip-Seq_BREAST_Human1.13553946
95DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13166417
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13111766
97* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13089402
98GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12913931
99ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12317342
100OCT4_18692474_ChIP-Seq_MEFs_Mouse1.12230007
101SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11795460
102CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11557365
103GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11422649
104MAF_26560356_Chip-Seq_TH2_Human1.10607584
105CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10293059
106* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10041497
107TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09873526
108SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09800995
109* CTCF_21964334_Chip-Seq_Bcells_Human1.09694531
110NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09461549
111* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09437411
112PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08977626
113* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08008659
114CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07938094
115RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07606822
116HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07553826
117* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06888160
118POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.06428259
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.05893224
120SOX2_18692474_ChIP-Seq_MEFs_Mouse1.05765462
121VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05588610
122YY1_21170310_ChIP-Seq_MESCs_Mouse1.05524960
123ETS1_20019798_ChIP-Seq_JURKAT_Human1.05407567
124SOX2_18692474_ChIP-Seq_MESCs_Mouse1.05337591
125ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04986193
126STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04661709
127CTCF_27219007_Chip-Seq_Bcells_Human1.04291218
128* ATF3_27146783_Chip-Seq_COLON_Human1.03758608
129SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02716788
130E2F1_21310950_ChIP-Seq_MCF-7_Human1.02415253
131* RUNX1_22412390_ChIP-Seq_EML_Mouse1.02388266
132GABP_19822575_ChIP-Seq_HepG2_Human1.02103259
133PHF8_20622854_ChIP-Seq_HELA_Human1.02090021
134NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.01635998
135SA1_27219007_Chip-Seq_Bcells_Human1.01406360
136* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.01392070
137* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00640827
138VDR_24763502_ChIP-Seq_THP-1_Human0.99830924
139SCL_19346495_ChIP-Seq_HPC-7_Human0.99806486
140SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99640303
141* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99281873
142PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.99038498
143CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98922930
144SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98792608
145* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97625234
146FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.96775932
147MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.96346749
148TP63_19390658_ChIP-ChIP_HaCaT_Human0.95840539
149TET1_21451524_ChIP-Seq_MESCs_Mouse0.95829840
150RARA_24833708_ChIP-Seq_LIVER_Mouse0.95825260
151* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95762086
152PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95691788
153BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94738683
154* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94729148
155ESR2_21235772_ChIP-Seq_MCF-7_Human0.93834807

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.98022624
2MP0009278_abnormal_bone_marrow2.98864714
3MP0010352_gastrointestinal_tract_polyps2.97914170
4MP0008260_abnormal_autophagy2.77056715
5MP0005451_abnormal_body_composition2.69220826
6MP0004957_abnormal_blastocyst_morpholog2.52612910
7MP0005397_hematopoietic_system_phenotyp2.46226858
8MP0001545_abnormal_hematopoietic_system2.46226858
9MP0005076_abnormal_cell_differentiation2.39132187
10MP0005058_abnormal_lysosome_morphology2.38215881
11MP0003111_abnormal_nucleus_morphology2.36876871
12MP0005083_abnormal_biliary_tract2.35868233
13MP0002653_abnormal_ependyma_morphology2.26854412
14MP0010094_abnormal_chromosome_stability2.26848347
15MP0003077_abnormal_cell_cycle2.18907157
16MP0010030_abnormal_orbit_morphology2.14609737
17MP0003705_abnormal_hypodermis_morpholog2.14550882
18MP0005257_abnormal_intraocular_pressure2.12812670
19MP0000685_abnormal_immune_system2.06224576
20MP0000490_abnormal_crypts_of2.02427314
21MP0004858_abnormal_nervous_system2.01738713
22MP0003123_paternal_imprinting1.97883917
23MP0003300_gastrointestinal_ulcer1.96937509
24MP0003693_abnormal_embryo_hatching1.96837934
25MP0003656_abnormal_erythrocyte_physiolo1.84008883
26MP0010307_abnormal_tumor_latency1.81325673
27MP0000350_abnormal_cell_proliferation1.81079689
28MP0000678_abnormal_parathyroid_gland1.72690858
29MP0001348_abnormal_lacrimal_gland1.71029904
30MP0002086_abnormal_extraembryonic_tissu1.70419232
31MP0002419_abnormal_innate_immunity1.69270174
32MP0004947_skin_inflammation1.68449986
33MP0003890_abnormal_embryonic-extraembry1.68347313
34MP0005025_abnormal_response_to1.63081874
35MP0004197_abnormal_fetal_growth/weight/1.61634606
36MP0001672_abnormal_embryogenesis/_devel1.53412508
37MP0005380_embryogenesis_phenotype1.53412508
38MP0002084_abnormal_developmental_patter1.51937203
39MP0003453_abnormal_keratinocyte_physiol1.51724193
40MP0001697_abnormal_embryo_size1.51405017
41MP0005000_abnormal_immune_tolerance1.49809416
42MP0003119_abnormal_digestive_system1.49015244
43MP0002089_abnormal_postnatal_growth/wei1.48922860
44MP0004510_myositis1.47565467
45MP0001730_embryonic_growth_arrest1.46210108
46MP0004133_heterotaxia1.45582138
47MP0008058_abnormal_DNA_repair1.44995540
48MP0006082_CNS_inflammation1.44044397
49MP0002396_abnormal_hematopoietic_system1.43734068
50MP0002085_abnormal_embryonic_tissue1.42692654
51MP0008007_abnormal_cellular_replicative1.41867183
52MP0009333_abnormal_splenocyte_physiolog1.40105490
53MP0002019_abnormal_tumor_incidence1.39723090
54MP0003172_abnormal_lysosome_physiology1.38357193
55MP0003724_increased_susceptibility_to1.37053441
56MP0002877_abnormal_melanocyte_morpholog1.36427390
57MP0003984_embryonic_growth_retardation1.35733528
58MP0002398_abnormal_bone_marrow1.34935442
59MP0002723_abnormal_immune_serum1.34899123
60* MP0001819_abnormal_immune_cell1.34548951
61MP0002088_abnormal_embryonic_growth/wei1.34013299
62* MP0002420_abnormal_adaptive_immunity1.33473688
63MP0001293_anophthalmia1.31943933
64MP0002405_respiratory_system_inflammati1.31676850
65MP0009840_abnormal_foam_cell1.31032403
66MP0002080_prenatal_lethality1.30430371
67MP0002009_preneoplasia1.29894519
68MP0004264_abnormal_extraembryonic_tissu1.28701529
69MP0002138_abnormal_hepatobiliary_system1.26115222
70MP0001533_abnormal_skeleton_physiology1.25897985
71* MP0000689_abnormal_spleen_morphology1.24215804
72MP0002722_abnormal_immune_system1.23944109
73MP0005377_hearing/vestibular/ear_phenot1.22431575
74MP0003878_abnormal_ear_physiology1.22431575
75MP0000858_altered_metastatic_potential1.21823377
76MP0003329_amyloid_beta_deposits1.20386987
77MP0003786_premature_aging1.19933159
78MP0003566_abnormal_cell_adhesion1.19057484
79MP0005023_abnormal_wound_healing1.17830981
80MP0003436_decreased_susceptibility_to1.15895393
81* MP0000313_abnormal_cell_death1.15866992
82MP0003763_abnormal_thymus_physiology1.14235312
83MP0000703_abnormal_thymus_morphology1.14177178
84MP0005671_abnormal_response_to1.13497032
85MP0003806_abnormal_nucleotide_metabolis1.13265653
86MP0004233_abnormal_muscle_weight1.12516357
87MP0009785_altered_susceptibility_to1.10866744
88MP0008932_abnormal_embryonic_tissue1.10829265
89MP0001849_ear_inflammation1.10046781
90MP0004381_abnormal_hair_follicle1.09471679
91MP0002998_abnormal_bone_remodeling1.09290898
92MP0003879_abnormal_hair_cell1.09073947
93MP0003942_abnormal_urinary_system1.07989598
94MP0000015_abnormal_ear_pigmentation1.07366057
95MP0005075_abnormal_melanosome_morpholog1.06541950
96MP0003283_abnormal_digestive_organ1.04672833
97MP0009379_abnormal_foot_pigmentation1.02869986
98MP0010155_abnormal_intestine_physiology1.02682308
99MP0001542_abnormal_bone_strength1.01617427
100MP0001915_intracranial_hemorrhage1.01324069
101MP0003091_abnormal_cell_migration1.00922788
102* MP0002429_abnormal_blood_cell0.99107450
103MP0003221_abnormal_cardiomyocyte_apopto0.98291259
104MP0009764_decreased_sensitivity_to0.97689001
105MP0006292_abnormal_olfactory_placode0.96338827
106MP0001800_abnormal_humoral_immune0.95597126
107MP0004808_abnormal_hematopoietic_stem0.94186650
108MP0003448_altered_tumor_morphology0.92710850
109MP0001835_abnormal_antigen_presentation0.91815796
110MP0003567_abnormal_fetal_cardiomyocyte0.91650328
111MP0000750_abnormal_muscle_regeneration0.91567040
112MP0009053_abnormal_anal_canal0.90687200
113MP0005464_abnormal_platelet_physiology0.90619247
114* MP0000716_abnormal_immune_system0.90454584
115MP0001663_abnormal_digestive_system0.89710840
116MP0000477_abnormal_intestine_morphology0.89177619
117MP0003191_abnormal_cellular_cholesterol0.88716322
118MP0005501_abnormal_skin_physiology0.87800271
119MP0000371_diluted_coat_color0.87766026
120MP0002148_abnormal_hypersensitivity_rea0.87226633
121MP0005248_abnormal_Harderian_gland0.87037348
122MP0003303_peritoneal_inflammation0.86307170
123MP0002132_abnormal_respiratory_system0.86222952
124MP0002092_abnormal_eye_morphology0.85737400
125MP0005390_skeleton_phenotype0.85706910
126MP0002166_altered_tumor_susceptibility0.85523035
127MP0008770_decreased_survivor_rate0.84991200
128MP0000598_abnormal_liver_morphology0.84317939
129MP0004185_abnormal_adipocyte_glucose0.83335104
130MP0000609_abnormal_liver_physiology0.82889595
131MP0002111_abnormal_tail_morphology0.82657880
132MP0002254_reproductive_system_inflammat0.81464588
133MP0001845_abnormal_inflammatory_respons0.80568769
134MP0001873_stomach_inflammation0.80400899
135MP0009931_abnormal_skin_appearance0.80217846
136MP0008995_early_reproductive_senescence0.79984873
137MP0005174_abnormal_tail_pigmentation0.79644072
138MP0000604_amyloidosis0.79060081
139MP0002006_tumorigenesis0.78818682
140MP0002970_abnormal_white_adipose0.77619131
141MP0002452_abnormal_antigen_presenting0.77439407
142MP0002249_abnormal_larynx_morphology0.77013795
143MP0005310_abnormal_salivary_gland0.75648001
144MP0003828_pulmonary_edema0.74574137
145MP0001790_abnormal_immune_system0.73818727
146MP0005387_immune_system_phenotype0.73818727
147MP0002697_abnormal_eye_size0.73058989
148MP0003279_aneurysm0.73056576
149MP0002925_abnormal_cardiovascular_devel0.72784809
150MP0008469_abnormal_protein_level0.69753680
151MP0000428_abnormal_craniofacial_morphol0.67389145
152MP0005666_abnormal_adipose_tissue0.66187121
153MP0003866_abnormal_defecation0.64063538

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)4.80949494
2Hypochromic microcytic anemia (HP:0004840)4.58118864
3Pustule (HP:0200039)4.16642058
4Hypochromic anemia (HP:0001931)3.50039783
5Eczematoid dermatitis (HP:0000976)3.36823893
6Ependymoma (HP:0002888)3.34264819
7Rectovaginal fistula (HP:0000143)3.31905734
8Rectal fistula (HP:0100590)3.31905734
9Increased IgM level (HP:0003496)3.18944569
10Ulnar bowing (HP:0003031)3.17566611
11Intestinal fistula (HP:0100819)3.16703267
12Long palpebral fissure (HP:0000637)3.16057062
13Poikiloderma (HP:0001029)3.15725413
14Gastrointestinal infarctions (HP:0005244)3.13041428
15Vaginal fistula (HP:0004320)3.10110617
16Hypertensive crisis (HP:0100735)3.04588826
17Facial hemangioma (HP:0000329)3.02946661
18Basal cell carcinoma (HP:0002671)3.01665566
19Abnormality of the astrocytes (HP:0100707)2.99258441
20Astrocytoma (HP:0009592)2.99258441
21Tongue fasciculations (HP:0001308)2.95973265
22Short humerus (HP:0005792)2.95282393
23Recurrent bacterial skin infections (HP:0005406)2.89795468
24Aplasia/hypoplasia of the humerus (HP:0006507)2.88487797
25Abnormality of macrophages (HP:0004311)2.87574080
26Obstructive lung disease (HP:0006536)2.82560297
27Chronic obstructive pulmonary disease (HP:0006510)2.82560297
28Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.81125457
29Hyperthyroidism (HP:0000836)2.77429251
30Annular pancreas (HP:0001734)2.76270036
31Recurrent abscess formation (HP:0002722)2.73570992
32Muscle fibrillation (HP:0010546)2.73225469
33Selective tooth agenesis (HP:0001592)2.71987454
34Vertebral hypoplasia (HP:0008417)2.71816554
35Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.71816554
36Cerebral aneurysm (HP:0004944)2.70884628
37Disproportionate tall stature (HP:0001519)2.63228618
38Abnormality of the lower motor neuron (HP:0002366)2.62290623
39Polycythemia (HP:0001901)2.61991700
40Deep palmar crease (HP:0006191)2.60877759
41Abnormality of the thoracic spine (HP:0100711)2.60203307
42Turricephaly (HP:0000262)2.60168339
43Microcytic anemia (HP:0001935)2.59658150
44Cellulitis (HP:0100658)2.53102833
45Hyperacusis (HP:0010780)2.49731318
46Abnormality of the fingertips (HP:0001211)2.49073155
47Orthostatic hypotension (HP:0001278)2.46361823
48Abnormal hemoglobin (HP:0011902)2.44152764
49Thin bony cortex (HP:0002753)2.43576050
50Vertebral fusion (HP:0002948)2.43526348
51Reticulocytosis (HP:0001923)2.43414326
52Concave nail (HP:0001598)2.40633557
53Segmental peripheral demyelination/remyelination (HP:0003481)2.38444876
54Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.34532838
55Squamous cell carcinoma (HP:0002860)2.33988192
56Insomnia (HP:0100785)2.32369721
57Thoracic kyphosis (HP:0002942)2.31187204
58Metaphyseal cupping (HP:0003021)2.25225788
59Alopecia of scalp (HP:0002293)2.22549303
60Multiple enchondromatosis (HP:0005701)2.22248143
61Short 5th finger (HP:0009237)2.21640201
62Obstructive sleep apnea (HP:0002870)2.21244751
63Truncus arteriosus (HP:0001660)2.21029342
64Mediastinal lymphadenopathy (HP:0100721)2.20932140
65Rectal prolapse (HP:0002035)2.19750774
66Pallor (HP:0000980)2.15741913
67Emphysema (HP:0002097)2.14362306
68Glioma (HP:0009733)2.12665278
69Neoplasm of the oral cavity (HP:0100649)2.12050221
70Myositis (HP:0100614)2.10261468
71Absent radius (HP:0003974)2.10026927
72Absent thumb (HP:0009777)2.09666030
73Aplasia/Hypoplasia of the sacrum (HP:0008517)2.08729933
74Rhabdomyosarcoma (HP:0002859)2.07300817
75Neoplasm of striated muscle (HP:0009728)2.05499766
76Heterotopia (HP:0002282)2.04786779
77Patellar aplasia (HP:0006443)2.04781692
78Achilles tendon contracture (HP:0001771)2.04463726
79Increased cerebral lipofuscin (HP:0011813)2.03034072
80Increased IgE level (HP:0003212)2.02886626
81Orchitis (HP:0100796)2.02541628
82Broad distal phalanx of finger (HP:0009836)2.02507256
83Spinal muscular atrophy (HP:0007269)2.01899313
84Missing ribs (HP:0000921)2.01719385
85Atelectasis (HP:0100750)2.01341023
86Bowed forearm bones (HP:0003956)1.99586037
87Bowing of the arm (HP:0006488)1.99586037
88Abnormality of reticulocytes (HP:0004312)1.99262149
89Broad alveolar ridges (HP:0000187)1.99123298
90Poikilocytosis (HP:0004447)1.97893929
91Abnormality of the heme biosynthetic pathway (HP:0010472)1.97889117
92Abnormality of the aortic arch (HP:0012303)1.97705766
93Abnormal platelet volume (HP:0011876)1.96969207
94Polygenic inheritance (HP:0010982)1.95985291
95Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.95440875
96Hemorrhage of the eye (HP:0011885)1.94081004
97Absent forearm bone (HP:0003953)1.92691627
98Aplasia involving forearm bones (HP:0009822)1.92691627
99Increased mean platelet volume (HP:0011877)1.91267136
100Colitis (HP:0002583)1.90234671
101Albinism (HP:0001022)1.89042829
102Gingivitis (HP:0000230)1.88987687
103Myocardial infarction (HP:0001658)1.87887138
104Congenital hip dislocation (HP:0001374)1.87792894
105Hypercortisolism (HP:0001578)1.87229317
106Urinary glycosaminoglycan excretion (HP:0003541)1.86436255
107Mucopolysacchariduria (HP:0008155)1.86436255
108Pseudobulbar signs (HP:0002200)1.86084409
109Mitral regurgitation (HP:0001653)1.85274979
110Hyperparathyroidism (HP:0000843)1.85223899
111Upper limb amyotrophy (HP:0009129)1.85107268
112Distal upper limb amyotrophy (HP:0007149)1.85107268
113Bilateral sensorineural hearing impairment (HP:0008619)1.84243610
114Abnormal vertebral ossification (HP:0100569)1.83560512
115Supranuclear gaze palsy (HP:0000605)1.82606172
116Aplasia/Hypoplasia of the patella (HP:0006498)1.82407557
117Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.82222679
118Easy fatigability (HP:0003388)1.81875909
119Peritonitis (HP:0002586)1.81785980
120Diaphragmatic weakness (HP:0009113)1.81540511
121Vertebral compression fractures (HP:0002953)1.81494612
122Cheilitis (HP:0100825)1.81371825
123Genu recurvatum (HP:0002816)1.81211877
124Gastrointestinal stroma tumor (HP:0100723)1.80950728
125Syringomyelia (HP:0003396)1.80899689
126Spinal cord lesions (HP:0100561)1.80899689
127Increased serum ferritin (HP:0003281)1.80435942
128Supernumerary nipples (HP:0002558)1.80398170
129Purpura (HP:0000979)1.80263391
130Nasal polyposis (HP:0100582)1.80261181
131Cutaneous melanoma (HP:0012056)1.78381760
132Hypoparathyroidism (HP:0000829)1.77954403
133Abnormal number of erythroid precursors (HP:0012131)1.77352018
134Abnormality of the Achilles tendon (HP:0005109)1.77043798
135Abnormality of cells of the erythroid lineage (HP:0012130)1.75429633
136Hand muscle atrophy (HP:0009130)1.75143736
137Vertebral clefting (HP:0008428)1.74025193
138Cholelithiasis (HP:0001081)1.73897317
139Intestinal atresia (HP:0011100)1.73781142
140Increased neuronal autofluorescent lipopigment (HP:0002074)1.72879149
141Prolonged bleeding time (HP:0003010)1.72699821
142Acute lymphatic leukemia (HP:0006721)1.72151473
143Trismus (HP:0000211)1.72119785
144Urticaria (HP:0001025)1.71960637
145Lower limb hyperreflexia (HP:0002395)1.71145993
146Persistence of primary teeth (HP:0006335)1.70618226
147Spastic diplegia (HP:0001264)1.70452666
148Elevated erythrocyte sedimentation rate (HP:0003565)1.69976008
149Dysautonomia (HP:0002459)1.69937562
150Abnormality of T cell physiology (HP:0011840)1.68860169
151Medulloblastoma (HP:0002885)1.68854412
152Atrophy/Degeneration involving motor neurons (HP:0007373)1.68277069
153Broad palm (HP:0001169)1.67688476
154Spontaneous hematomas (HP:0007420)1.67062823
155Abnormality of mucopolysaccharide metabolism (HP:0011020)1.66925571
156Abnormality of polysaccharide metabolism (HP:0011012)1.66925571
157Abnormality of glycosaminoglycan metabolism (HP:0004371)1.66925571
158Abnormality of the motor neurons (HP:0002450)1.66878929
159Abnormal neuron morphology (HP:0012757)1.66878929
160Abnormality of the phalanges of the hallux (HP:0010057)1.66589781
161Hypercalcemia (HP:0003072)1.66547851
162Abnormality of the nasal mucosa (HP:0000433)1.65702542
163Bowel incontinence (HP:0002607)1.65521676
164Patellar dislocation (HP:0002999)1.65290872
165Abnormality of the anterior horn cell (HP:0006802)1.65274231
166Degeneration of anterior horn cells (HP:0002398)1.65274231
167Agnosia (HP:0010524)1.64802872
168Myopathic facies (HP:0002058)1.64676876
169Abnormal number of incisors (HP:0011064)1.64372801
170Entropion (HP:0000621)1.64338829
171Gastrointestinal inflammation (HP:0004386)1.63954090
172Hemivertebrae (HP:0002937)1.61731981
173Abnormal large intestine physiology (HP:0012700)1.61377197
174Decreased motor nerve conduction velocity (HP:0003431)1.61353973
175Renal cell carcinoma (HP:0005584)1.60404197
176Joint stiffness (HP:0001387)1.60289707
177Partial duplication of thumb phalanx (HP:0009944)1.60269484
178Retrobulbar optic neuritis (HP:0100654)1.60245751
179Skin tags (HP:0010609)1.59306898

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK3.90976049
2PRPF4B3.53934796
3CDK123.42019803
4SMG13.28308640
5MAP3K103.15673760
6MAPK152.50973023
7DDR22.41900627
8EEF2K2.40621225
9MAP3K112.38815903
10PIM22.37648134
11IRAK32.30661919
12ERN12.09721281
13MATK2.05260939
14MAP3K62.02374050
15PIM12.01476868
16BMX2.00356972
17TYRO31.96577590
18TRIB31.92871138
19IRAK41.79196990
20EPHA21.77738034
21DYRK1B1.76879681
22MARK21.73030147
23STK101.71349266
24GRK61.71027332
25CDK71.70262402
26MAP4K11.67608862
27RIPK41.67532943
28CDK61.61388792
29CSK1.51043611
30NEK21.48014424
31FLT31.46333298
32DYRK31.45874670
33PDGFRA1.45059260
34PKN21.43399353
35RPS6KB21.40509719
36MAP3K31.38445848
37PRKD21.37136838
38CAMK1D1.35426143
39MAP3K131.31819702
40FGR1.29586659
41MAP3K11.29405908
42RPS6KA21.24016625
43ARAF1.22939461
44BRAF1.22208067
45EPHB11.21483910
46DAPK11.14616153
47MTOR1.12592576
48IRAK21.10733008
49KSR21.09943105
50CDK41.08532509
51ALK1.06946897
52BLK1.06824359
53CHEK21.05298538
54FES1.02868660
55MAPK111.00866533
56SIK30.99925567
57MAPKAPK30.97339481
58NME20.96813504
59CDC70.96638377
60RPS6KC10.95892093
61RPS6KL10.95892093
62PAK40.95544666
63SCYL20.93913690
64PLK10.93011783
65UHMK10.92957119
66LATS20.91684079
67TGFBR20.90149751
68RPS6KA60.89376395
69JAK30.87268247
70MAP3K140.83937157
71ACVR1B0.83517211
72MAP3K90.83312761
73TYK20.82579890
74CDK190.81676548
75YES10.81047011
76ZAP700.79000350
77TBK10.78896678
78RPS6KA10.78667154
79PDPK10.78472849
80CSF1R0.77047594
81MAP3K80.76918034
82TESK20.76374157
83FGFR40.75713972
84ATR0.75129500
85SIK10.74643506
86PTK20.72808012
87GSK3A0.72586284
88MAP2K20.72514755
89BTK0.71937660
90MAP2K30.69571237
91HIPK20.69401431
92TNK20.68700497
93RIPK10.68100162
94WEE10.67706348
95SIK20.67489324
96STK40.66808039
97TAOK10.64622258
98BUB10.64332150
99TTK0.63932004
100IKBKE0.63334924
101CHEK10.63184726
102HCK0.63013964
103CDK20.62679015
104MARK30.61480640
105AURKA0.60230932
106CAMK1G0.59963018
107TAOK20.56803863
108MAPK120.56223755
109SGK30.55954131
110MAP3K70.55465569
111CDC42BPA0.54795138
112MAPKAPK20.54624810
113BRD40.54586238
114* IKBKB0.53611094
115NEK10.51882430
116STK110.51706723
117AURKB0.51170517
118JAK20.50868176
119AKT20.50633929
120PRKD30.50571681
121LRRK20.49064080
122IRAK10.47484947
123TRPM70.47459505
124PTK60.47321359
125TTN0.47212016
126PAK20.46616447
127RPS6KA40.46246317
128DAPK30.45547533
129WNK10.45181426
130PDK10.44651922
131MAPK10.44521627
132DYRK20.44195128
133EGFR0.44050969
134* CHUK0.42916565
135PIK3CA0.41158630
136LCK0.41006192
137PINK10.38614927
138MAP2K40.38102409
139ABL20.37747157
140ATM0.37088939
141TGFBR10.37031705
142TLK10.36059132
143PRKCI0.35583588
144EPHB20.34923424
145MAPK30.33851234
146PRKAA10.32785433
147MOS0.32723022
148LYN0.31627932
149AKT10.30335469
150PRKCZ0.27879037

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.25309076
2DNA replication_Homo sapiens_hsa030303.15213799
3Base excision repair_Homo sapiens_hsa034102.92741061
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.31285808
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.26840469
6Spliceosome_Homo sapiens_hsa030402.04119453
7One carbon pool by folate_Homo sapiens_hsa006702.03579304
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.01515636
9RNA transport_Homo sapiens_hsa030132.00651265
10* p53 signaling pathway_Homo sapiens_hsa041151.97593538
11mTOR signaling pathway_Homo sapiens_hsa041501.87902481
12Other glycan degradation_Homo sapiens_hsa005111.83884598
13Sulfur relay system_Homo sapiens_hsa041221.78954973
14Notch signaling pathway_Homo sapiens_hsa043301.70641801
15mRNA surveillance pathway_Homo sapiens_hsa030151.69067893
16Cell cycle_Homo sapiens_hsa041101.68719035
17Bladder cancer_Homo sapiens_hsa052191.66265432
18Nucleotide excision repair_Homo sapiens_hsa034201.64004899
19Malaria_Homo sapiens_hsa051441.61363446
20Fatty acid biosynthesis_Homo sapiens_hsa000611.56901073
21Chronic myeloid leukemia_Homo sapiens_hsa052201.56729365
22Acute myeloid leukemia_Homo sapiens_hsa052211.54577564
23Ribosome_Homo sapiens_hsa030101.51808520
24Renal cell carcinoma_Homo sapiens_hsa052111.41855679
25Transcriptional misregulation in cancer_Homo sapiens_hsa052021.38155635
26Viral carcinogenesis_Homo sapiens_hsa052031.31950116
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.31125403
28TNF signaling pathway_Homo sapiens_hsa046681.27511707
29Hepatitis C_Homo sapiens_hsa051601.27259787
30Herpes simplex infection_Homo sapiens_hsa051681.26705999
31Thyroid cancer_Homo sapiens_hsa052161.23730725
32Small cell lung cancer_Homo sapiens_hsa052221.21372254
33Primary immunodeficiency_Homo sapiens_hsa053401.20935340
34Legionellosis_Homo sapiens_hsa051341.19341905
35ErbB signaling pathway_Homo sapiens_hsa040121.19340177
36Tuberculosis_Homo sapiens_hsa051521.18381794
37Biosynthesis of amino acids_Homo sapiens_hsa012301.17498361
38Shigellosis_Homo sapiens_hsa051311.16551474
39Homologous recombination_Homo sapiens_hsa034401.15389988
40FoxO signaling pathway_Homo sapiens_hsa040681.14308339
41MicroRNAs in cancer_Homo sapiens_hsa052061.13440798
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.11460756
43Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10568587
44Colorectal cancer_Homo sapiens_hsa052101.09663606
45Folate biosynthesis_Homo sapiens_hsa007901.07510759
46Adherens junction_Homo sapiens_hsa045201.07500302
47Chemokine signaling pathway_Homo sapiens_hsa040621.05941743
48Longevity regulating pathway - mammal_Homo sapiens_hsa042111.05733060
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.05395454
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05131032
51* Hippo signaling pathway_Homo sapiens_hsa043901.05086945
52Fructose and mannose metabolism_Homo sapiens_hsa000511.03399133
53Endocytosis_Homo sapiens_hsa041441.02452105
54Adipocytokine signaling pathway_Homo sapiens_hsa049201.02089443
55Fanconi anemia pathway_Homo sapiens_hsa034601.01412531
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.01351600
57Lysine degradation_Homo sapiens_hsa003101.01015316
58NOD-like receptor signaling pathway_Homo sapiens_hsa046211.00522101
59* Apoptosis_Homo sapiens_hsa042101.00115532
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99978931
61Selenocompound metabolism_Homo sapiens_hsa004500.98893730
62B cell receptor signaling pathway_Homo sapiens_hsa046620.97925929
63* Measles_Homo sapiens_hsa051620.97110307
64Glioma_Homo sapiens_hsa052140.96657043
65HTLV-I infection_Homo sapiens_hsa051660.95341482
66Hepatitis B_Homo sapiens_hsa051610.94423309
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92643018
68Leishmaniasis_Homo sapiens_hsa051400.90707982
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.89322881
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88854438
71VEGF signaling pathway_Homo sapiens_hsa043700.88483110
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87555499
73MAPK signaling pathway_Homo sapiens_hsa040100.87378795
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87251551
75Systemic lupus erythematosus_Homo sapiens_hsa053220.87120467
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.86574928
77Epstein-Barr virus infection_Homo sapiens_hsa051690.86136077
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84951571
79Viral myocarditis_Homo sapiens_hsa054160.84795729
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.84466585
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84428487
82Basal cell carcinoma_Homo sapiens_hsa052170.84211810
83Antigen processing and presentation_Homo sapiens_hsa046120.84204690
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84034739
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83851256
86Salmonella infection_Homo sapiens_hsa051320.83401563
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.83037133
88Hedgehog signaling pathway_Homo sapiens_hsa043400.80748914
89Choline metabolism in cancer_Homo sapiens_hsa052310.80643818
90Lysosome_Homo sapiens_hsa041420.80462910
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.79894814
92Pancreatic cancer_Homo sapiens_hsa052120.77551776
93Non-small cell lung cancer_Homo sapiens_hsa052230.76201575
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.73568889
95Staphylococcus aureus infection_Homo sapiens_hsa051500.72663873
96Type II diabetes mellitus_Homo sapiens_hsa049300.72473093
97Endometrial cancer_Homo sapiens_hsa052130.72220550
98GnRH signaling pathway_Homo sapiens_hsa049120.70623780
99Inositol phosphate metabolism_Homo sapiens_hsa005620.70020871
100African trypanosomiasis_Homo sapiens_hsa051430.69087967
101Jak-STAT signaling pathway_Homo sapiens_hsa046300.68972858
102Axon guidance_Homo sapiens_hsa043600.67451943
103Glycosaminoglycan degradation_Homo sapiens_hsa005310.67110759
104Insulin resistance_Homo sapiens_hsa049310.64133521
105Rap1 signaling pathway_Homo sapiens_hsa040150.64076559
106Arginine biosynthesis_Homo sapiens_hsa002200.63915492
107Melanoma_Homo sapiens_hsa052180.63538534
108AMPK signaling pathway_Homo sapiens_hsa041520.63130427
109Alcoholism_Homo sapiens_hsa050340.62424369
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61935440
111RNA degradation_Homo sapiens_hsa030180.61908733
112Galactose metabolism_Homo sapiens_hsa000520.61758618
113Intestinal immune network for IgA production_Homo sapiens_hsa046720.61224864
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61222555
115Proteoglycans in cancer_Homo sapiens_hsa052050.61093871
116TGF-beta signaling pathway_Homo sapiens_hsa043500.60907137
1172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60756752
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60653221
119Phagosome_Homo sapiens_hsa041450.60340978
120Pentose phosphate pathway_Homo sapiens_hsa000300.59332265
121Osteoclast differentiation_Homo sapiens_hsa043800.57435005
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57028030
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56515350
124Arginine and proline metabolism_Homo sapiens_hsa003300.56262397
125Toxoplasmosis_Homo sapiens_hsa051450.55706521
126Influenza A_Homo sapiens_hsa051640.55041960
127Drug metabolism - other enzymes_Homo sapiens_hsa009830.54308920
128T cell receptor signaling pathway_Homo sapiens_hsa046600.53366398
129Pathways in cancer_Homo sapiens_hsa052000.53323232
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.52679909
131Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52654808
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52444774
133Prostate cancer_Homo sapiens_hsa052150.50585655
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.50415748
135Prolactin signaling pathway_Homo sapiens_hsa049170.47766891
136HIF-1 signaling pathway_Homo sapiens_hsa040660.44745165
137Prion diseases_Homo sapiens_hsa050200.43447304
138Pyrimidine metabolism_Homo sapiens_hsa002400.43309039
139Insulin signaling pathway_Homo sapiens_hsa049100.42601393
140Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42469277
141Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42396950
142Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40672191
143Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40061590
144Wnt signaling pathway_Homo sapiens_hsa043100.37973992

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