BBOF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.60287210
2sperm-egg recognition (GO:0035036)9.58148405
3cell wall macromolecule catabolic process (GO:0016998)8.77824879
4cell wall macromolecule metabolic process (GO:0044036)8.77824879
5motile cilium assembly (GO:0044458)8.68137034
6acrosome reaction (GO:0007340)8.65316503
7cell-cell recognition (GO:0009988)8.51864337
8plasma membrane fusion (GO:0045026)8.42776340
9binding of sperm to zona pellucida (GO:0007339)8.40822441
10piRNA metabolic process (GO:0034587)8.31886320
11reproduction (GO:0000003)8.14201266
12male meiosis (GO:0007140)8.09157507
13regulation of cilium movement (GO:0003352)7.90365219
14spermatid development (GO:0007286)7.61747311
15sperm capacitation (GO:0048240)7.07207330
16single fertilization (GO:0007338)6.97751492
17synaptonemal complex organization (GO:0070193)6.83136669
18ventricular system development (GO:0021591)6.63791379
19synaptonemal complex assembly (GO:0007130)6.48737142
20fertilization (GO:0009566)5.69304597
21DNA methylation involved in gamete generation (GO:0043046)5.41867843
22protein localization to cilium (GO:0061512)5.27844959
23microtubule severing (GO:0051013)5.14462684
24male meiosis I (GO:0007141)5.13720474
25negative regulation of inclusion body assembly (GO:0090084)5.12462230
26axoneme assembly (GO:0035082)5.08505225
27intraciliary transport (GO:0042073)5.07403085
28spermatogenesis (GO:0007283)4.83919253
29male gamete generation (GO:0048232)4.82470177
30cell recognition (GO:0008037)4.81642321
31primary alcohol catabolic process (GO:0034310)4.65865754
32calcium ion-dependent exocytosis (GO:0017156)4.62820758
33regulation of microtubule-based movement (GO:0060632)4.57002805
34chromosome organization involved in meiosis (GO:0070192)4.52462846
35gamete generation (GO:0007276)4.46106755
36cellular process involved in reproduction in multicellular organism (GO:0022412)4.42467720
37left/right pattern formation (GO:0060972)4.38057729
38spermatid nucleus differentiation (GO:0007289)4.35152437
39germ cell development (GO:0007281)4.34418635
40protein polyglutamylation (GO:0018095)4.31716304
41diterpenoid biosynthetic process (GO:0016102)4.29854616
42meiotic nuclear division (GO:0007126)4.23943076
43cilium organization (GO:0044782)4.22443124
44ethanol metabolic process (GO:0006067)4.19303406
45microtubule depolymerization (GO:0007019)4.19023336
46cilium assembly (GO:0042384)4.06703938
47meiosis I (GO:0007127)4.00957930
48organic cation transport (GO:0015695)4.00152169
49one-carbon compound transport (GO:0019755)3.99961963
50regulation of inclusion body assembly (GO:0090083)3.91499604
51microtubule-based movement (GO:0007018)3.84807611
52vitamin transmembrane transport (GO:0035461)3.74705826
53cellular component assembly involved in morphogenesis (GO:0010927)3.72547907
54cilium morphogenesis (GO:0060271)3.67844141
55nucleoside diphosphate phosphorylation (GO:0006165)3.65667764
56meiotic cell cycle (GO:0051321)3.61239004
57seminiferous tubule development (GO:0072520)3.56906472
58GTP biosynthetic process (GO:0006183)3.54938232
59centriole replication (GO:0007099)3.54935666
60response to xenobiotic stimulus (GO:0009410)3.53485740
61multicellular organismal reproductive process (GO:0048609)3.50079758
62pyrimidine-containing compound transmembrane transport (GO:0072531)3.48788848
63determination of left/right symmetry (GO:0007368)3.32087662
64lung epithelium development (GO:0060428)3.25738120
65genitalia morphogenesis (GO:0035112)3.25017487
66monoubiquitinated protein deubiquitination (GO:0035520)3.22055986
67glutathione derivative metabolic process (GO:1901685)3.20104186
68glutathione derivative biosynthetic process (GO:1901687)3.20104186
69nonmotile primary cilium assembly (GO:0035058)3.19815814
70centriole assembly (GO:0098534)3.18692296
71determination of bilateral symmetry (GO:0009855)3.18667227
72left/right axis specification (GO:0070986)3.16868375
73calcium ion import (GO:0070509)3.16278437
74mitochondrion degradation (GO:0000422)3.15228536
75specification of symmetry (GO:0009799)3.12644344
76smoothened signaling pathway (GO:0007224)3.12113239
77ethanol oxidation (GO:0006069)3.09998381
78terpenoid biosynthetic process (GO:0016114)3.03459227
79negative regulation of humoral immune response (GO:0002921)3.02093701
80retinal rod cell development (GO:0046548)2.99218062
81tolerance induction (GO:0002507)2.99164376
82lateral ventricle development (GO:0021670)2.98118615
83UTP biosynthetic process (GO:0006228)2.97129766
84negative regulation of T cell differentiation in thymus (GO:0033085)2.97070021
85lactate metabolic process (GO:0006089)2.96554103
86photoreceptor cell maintenance (GO:0045494)2.95202489
87negative regulation of organelle assembly (GO:1902116)2.93670168
88regulation of germinal center formation (GO:0002634)2.93102550
89positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.93047133
90retinoic acid metabolic process (GO:0042573)2.89468226
91regulation of interleukin-5 production (GO:0032674)2.88744294
92negative regulation of immunoglobulin mediated immune response (GO:0002890)2.87388271
93negative regulation of B cell mediated immunity (GO:0002713)2.87388271
94regulation of interleukin-13 production (GO:0032656)2.84749274
95synapsis (GO:0007129)2.84391353
96glomerular epithelial cell development (GO:0072310)2.83807898
97protein K11-linked deubiquitination (GO:0035871)2.82852120
98microtubule-based process (GO:0007017)2.80498605
99regulation of autophagic vacuole assembly (GO:2000785)2.79404047
100microtubule bundle formation (GO:0001578)2.78417802
101membrane depolarization during action potential (GO:0086010)2.77820206
102multicellular organismal development (GO:0007275)2.77068036
103retinol metabolic process (GO:0042572)2.69066880
104carnitine transmembrane transport (GO:1902603)2.68033474
105cytoplasmic microtubule organization (GO:0031122)2.66807726
106UTP metabolic process (GO:0046051)2.64346828
107amino-acid betaine transport (GO:0015838)2.63141082
108carnitine transport (GO:0015879)2.63141082
109regulation of centriole replication (GO:0046599)2.62911957
110regulation of meiosis I (GO:0060631)2.62798317
111glycerol ether metabolic process (GO:0006662)2.59237596
112gas transport (GO:0015669)2.57207534
113phosphatidylcholine biosynthetic process (GO:0006656)2.54884895
114cell projection assembly (GO:0030031)2.53507576
115carnitine metabolic process (GO:0009437)2.53246818
116phosphatidylethanolamine biosynthetic process (GO:0006646)2.53059995
117microtubule polymerization or depolymerization (GO:0031109)2.52390137
118meiotic cell cycle process (GO:1903046)2.48654053
119androgen biosynthetic process (GO:0006702)2.48219285
120regulation of vacuole organization (GO:0044088)2.47249382
121alditol metabolic process (GO:0019400)2.45228865
122positive regulation of tolerance induction (GO:0002645)2.44885014
123establishment of monopolar cell polarity (GO:0061162)2.44767641
124establishment or maintenance of monopolar cell polarity (GO:0061339)2.44767641
125establishment of apical/basal cell polarity (GO:0035089)2.44590564
126peptidyl-glutamic acid modification (GO:0018200)2.44418702
127brain morphogenesis (GO:0048854)2.43428688
128lateral sprouting from an epithelium (GO:0060601)2.43193105
129retinal cone cell development (GO:0046549)2.42396376
130negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.42172033
131gene silencing by RNA (GO:0031047)2.41516211
132embryonic camera-type eye development (GO:0031076)2.41448925
133ether metabolic process (GO:0018904)2.41434679
134primary alcohol metabolic process (GO:0034308)2.41046536
135phosphatidylethanolamine metabolic process (GO:0046337)2.40850509
136polyol catabolic process (GO:0046174)2.40154028
137histone H3-K9 methylation (GO:0051567)2.39768571
138heart looping (GO:0001947)2.38898998
139glycerol metabolic process (GO:0006071)2.38614475
140organelle assembly (GO:0070925)2.37088024
141negative regulation of appetite (GO:0032099)2.34443690
142negative regulation of response to food (GO:0032096)2.34443690
143O-glycan processing (GO:0016266)2.33600263
144chaperone-mediated protein complex assembly (GO:0051131)2.33286733
145establishment of planar polarity (GO:0001736)2.32871897
146establishment of tissue polarity (GO:0007164)2.32871897
147phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.32469610
148protein refolding (GO:0042026)2.31330061
149regulation of acrosome reaction (GO:0060046)2.30875000
150regulation of inositol phosphate biosynthetic process (GO:0010919)2.30757135
151guanosine-containing compound biosynthetic process (GO:1901070)2.28199102
152glutathione metabolic process (GO:0006749)2.21716713
153regulation of cilium assembly (GO:1902017)2.21122621
154positive regulation of smoothened signaling pathway (GO:0045880)2.21085242
155cilium or flagellum-dependent cell motility (GO:0001539)15.3705287
156axonemal dynein complex assembly (GO:0070286)11.5496404
157fusion of sperm to egg plasma membrane (GO:0007342)10.8248928
158epithelial cilium movement (GO:0003351)10.6424872
159sperm motility (GO:0030317)10.5058754
160cilium movement (GO:0003341)10.4325541
161acrosome assembly (GO:0001675)10.4162405
162multicellular organism reproduction (GO:0032504)10.2667649

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.73223982
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.73040245
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.96352931
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.91731267
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.95697822
6ESR1_20079471_ChIP-ChIP_T-47D_Human2.63854451
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.56638438
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.49411516
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.43389985
10GBX2_23144817_ChIP-Seq_PC3_Human2.36596271
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.32665204
12FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.30438306
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.26306631
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.25909874
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.23480561
16VDR_22108803_ChIP-Seq_LS180_Human2.21708218
17CBX2_27304074_Chip-Seq_ESCs_Mouse2.19604190
18PIAS1_25552417_ChIP-Seq_VCAP_Human2.07040959
19TAF15_26573619_Chip-Seq_HEK293_Human2.05777864
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.00096340
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99133529
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.95864456
23ARNT_22903824_ChIP-Seq_MCF-7_Human1.91798731
24IGF1R_20145208_ChIP-Seq_DFB_Human1.90973501
25AHR_22903824_ChIP-Seq_MCF-7_Human1.84818132
26ZNF274_21170338_ChIP-Seq_K562_Hela1.83374513
27RNF2_27304074_Chip-Seq_NSC_Mouse1.81004977
28PCGF2_27294783_Chip-Seq_NPCs_Mouse1.73728548
29TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.70307277
30REST_21632747_ChIP-Seq_MESCs_Mouse1.69929680
31FOXM1_26456572_ChIP-Seq_MCF-7_Human1.69461781
32RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.68889003
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.67800082
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65252304
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.65121061
36NANOG_18555785_Chip-Seq_ESCs_Mouse1.64857523
37EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.63267856
38KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.62687901
39SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.60382275
40EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.56696422
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.55615708
42IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53107281
43CBP_20019798_ChIP-Seq_JUKART_Human1.53107281
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.50489525
45TAL1_26923725_Chip-Seq_HPCs_Mouse1.50018564
46NR3C1_21868756_ChIP-Seq_MCF10A_Human1.49267142
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47869352
48KDM2B_26808549_Chip-Seq_REH_Human1.47808319
49P53_22387025_ChIP-Seq_ESCs_Mouse1.44694040
50TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.44377909
51TP53_18474530_ChIP-ChIP_U2OS_Human1.42563156
52TP63_23658742_ChIP-Seq_EP156T_Human1.40484719
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40056920
54TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40056920
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39732409
56ER_23166858_ChIP-Seq_MCF-7_Human1.39574219
57SUZ12_18555785_Chip-Seq_ESCs_Mouse1.38751074
58CMYC_18555785_Chip-Seq_ESCs_Mouse1.38240780
59P300_18555785_Chip-Seq_ESCs_Mouse1.37687206
60EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.37472745
61OCT4_18555785_Chip-Seq_ESCs_Mouse1.37216343
62SMAD4_21799915_ChIP-Seq_A2780_Human1.36824015
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36745449
64ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36375715
65GATA1_26923725_Chip-Seq_HPCs_Mouse1.36340878
66STAT3_18555785_Chip-Seq_ESCs_Mouse1.34745841
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.34704817
68FUS_26573619_Chip-Seq_HEK293_Human1.33406510
69E2F1_18555785_Chip-Seq_ESCs_Mouse1.32697269
70NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.31778740
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31520093
72P300_19829295_ChIP-Seq_ESCs_Human1.30653062
73TBL1_22424771_ChIP-Seq_293T_Human1.29448287
74TP53_16413492_ChIP-PET_HCT116_Human1.28146633
75RUNX1_27457419_Chip-Seq_LIVER_Mouse1.26879836
76MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.26843456
77FLI1_21867929_ChIP-Seq_TH2_Mouse1.26456995
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26202111
79KLF4_18555785_Chip-Seq_ESCs_Mouse1.25927908
80TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24657061
81ELK4_26923725_Chip-Seq_MESODERM_Mouse1.24338648
82SOX2_18555785_Chip-Seq_ESCs_Mouse1.23004853
83ESRRB_18555785_Chip-Seq_ESCs_Mouse1.22321348
84TCF4_23295773_ChIP-Seq_U87_Human1.21603171
85CRX_20693478_ChIP-Seq_RETINA_Mouse1.21558080
86AR_21572438_ChIP-Seq_LNCaP_Human1.21439052
87RUNX2_22187159_ChIP-Seq_PCA_Human1.21386635
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.20339666
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19305531
90TCF4_22108803_ChIP-Seq_LS180_Human1.19236141
91GATA1_19941826_ChIP-Seq_K562_Human1.18217079
92STAT1_20625510_ChIP-Seq_HELA_Human1.17427447
93FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.15799435
94PHF8_20622853_ChIP-Seq_HELA_Human1.15499712
95CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.14991934
96CTCF_18555785_Chip-Seq_ESCs_Mouse1.14516441
97DROSHA_22980978_ChIP-Seq_HELA_Human1.14453333
98WDR5_24793694_ChIP-Seq_LNCAP_Human1.13883070
99SMRT_27268052_Chip-Seq_Bcells_Human1.13777213
100HNFA_21074721_ChIP-Seq_CACO-2_Human1.13518996
101OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12784141
102CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12766284
103GATA2_19941826_ChIP-Seq_K562_Human1.12733970
104ETV1_20927104_ChIP-Seq_GIST48_Human1.12493970
105STAT1_17558387_ChIP-Seq_HELA_Human1.12281389
106NFYB_21822215_ChIP-Seq_K562_Human1.11539859
107NMYC_18555785_Chip-Seq_ESCs_Mouse1.11367966
108PU1_27457419_Chip-Seq_LIVER_Mouse1.11005680
109KAP1_22055183_ChIP-Seq_ESCs_Mouse1.10792141
110STAT3_23295773_ChIP-Seq_U87_Human1.10787981
111AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10534724
112GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.09758837
113ZFX_18555785_Chip-Seq_ESCs_Mouse1.09710231
114BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09615475
115NFYA_21822215_ChIP-Seq_K562_Human1.07861024
116TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07606960
117SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.07065555
118SMAD1_18555785_Chip-Seq_ESCs_Mouse1.07014610
119CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.06793399
120BCAT_22108803_ChIP-Seq_LS180_Human1.06512511
121CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04661464
122PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.03874989
123TDRD3_21172665_ChIP-Seq_MCF-7_Human1.02186360
124EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02155071
125EZH2_27294783_Chip-Seq_ESCs_Mouse1.01932376
126NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01613685
127NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01613685
128CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01433670
129OCT1_27270436_Chip-Seq_PROSTATE_Human1.00788357
130CDX2_22108803_ChIP-Seq_LS180_Human1.00735304
131PRDM14_20953172_ChIP-Seq_ESCs_Human1.00126779
132FOXA1_25552417_ChIP-Seq_VCAP_Human0.99923914
133PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.99451113
134SOX9_26525672_Chip-Seq_HEART_Mouse0.99121310
135SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98665910
136EWS_26573619_Chip-Seq_HEK293_Human0.98129367
137VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97671228
138TRIM28_21343339_ChIP-Seq_HEK293_Human0.97269707
139SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96893864
140AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.96800643
141TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96721291
142SMAD4_21741376_ChIP-Seq_EPCs_Human0.95412570
143TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95368375
144AR_25329375_ChIP-Seq_VCAP_Human0.94887059
145RBPJ_21746931_ChIP-Seq_IB4_Human0.94515321
146SMAD3_21741376_ChIP-Seq_HESCs_Human0.94486245
147KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93932348
148PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93769865
149CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93355116
150TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.93277515
151FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92471609
152FOXA1_25329375_ChIP-Seq_VCAP_Human0.92471609
153GF1_26923725_Chip-Seq_HPCs_Mouse0.92178030
154ERG_20517297_ChIP-Seq_VCAP_Human0.92169599
155NANOG_19829295_ChIP-Seq_ESCs_Human0.92095671
156SOX2_19829295_ChIP-Seq_ESCs_Human0.92095671
157TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92027310
158SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91570557

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive4.81802438
2MP0002132_abnormal_respiratory_system4.72258023
3MP0008877_abnormal_DNA_methylation4.42916236
4MP0008875_abnormal_xenobiotic_pharmacok4.40168090
5MP0001929_abnormal_gametogenesis4.22188570
6MP0008789_abnormal_olfactory_epithelium3.77598438
7MP0002653_abnormal_ependyma_morphology3.48649200
8MP0008004_abnormal_stomach_pH3.18640233
9MP0005394_taste/olfaction_phenotype3.04831165
10MP0005499_abnormal_olfactory_system3.04831165
11MP0009046_muscle_twitch3.03633949
12MP0002210_abnormal_sex_determination2.78508762
13MP0003880_abnormal_central_pattern2.66409892
14MP0005623_abnormal_meninges_morphology2.62232194
15MP0002161_abnormal_fertility/fecundity2.55325714
16MP0000566_synostosis2.54967114
17MP0005083_abnormal_biliary_tract2.53250485
18MP0001145_abnormal_male_reproductive2.33327135
19MP0003656_abnormal_erythrocyte_physiolo2.23020321
20MP0001984_abnormal_olfaction2.17907954
21MP0000383_abnormal_hair_follicle2.16384987
22MP0002277_abnormal_respiratory_mucosa2.15934329
23MP0010030_abnormal_orbit_morphology2.10365965
24MP0005248_abnormal_Harderian_gland2.06083907
25MP0004859_abnormal_synaptic_plasticity2.04892388
26MP0000653_abnormal_sex_gland2.04845980
27MP0005410_abnormal_fertilization11.6520630
28MP0005464_abnormal_platelet_physiology1.86234882
29MP0010678_abnormal_skin_adnexa1.84658002
30MP0004019_abnormal_vitamin_homeostasis1.78427807
31MP0009745_abnormal_behavioral_response1.75696188
32MP0001440_abnormal_grooming_behavior1.73734877
33MP0002168_other_aberrant_phenotype1.72982313
34MP0003635_abnormal_synaptic_transmissio1.72852734
35MP0003646_muscle_fatigue1.64310495
36MP0002572_abnormal_emotion/affect_behav1.60774341
37MP0002233_abnormal_nose_morphology1.55912433
38MP0004270_analgesia1.53189386
39MP0002064_seizures1.50783907
40MP0003950_abnormal_plasma_membrane1.50409250
41MP0005551_abnormal_eye_electrophysiolog1.47991968
42MP0002272_abnormal_nervous_system1.47214202
43MP0002736_abnormal_nociception_after1.44742288
44MP0001486_abnormal_startle_reflex1.43968194
45MP0001968_abnormal_touch/_nociception1.38444172
46MP0002063_abnormal_learning/memory/cond1.38129713
47MP0005646_abnormal_pituitary_gland1.33719219
48MP0005423_abnormal_somatic_nervous1.32721325
49MP0003787_abnormal_imprinting1.31555306
50MP0002282_abnormal_trachea_morphology1.31237303
51MP0010386_abnormal_urinary_bladder1.30664605
52MP0002638_abnormal_pupillary_reflex1.29876460
53MP0005395_other_phenotype1.24048133
54MP0002160_abnormal_reproductive_system1.19448107
55MP0005408_hypopigmentation1.15112893
56MP0001765_abnormal_ion_homeostasis1.10119147
57MP0003136_yellow_coat_color1.09705908
58MP0001501_abnormal_sleep_pattern1.09555081
59MP0000778_abnormal_nervous_system1.08926849
60MP0002067_abnormal_sensory_capabilities1.08314306
61MP0002734_abnormal_mechanical_nocicepti1.05863556
62MP0001529_abnormal_vocalization1.04398032
63MP0008995_early_reproductive_senescence1.01563358
64MP0005645_abnormal_hypothalamus_physiol1.01477559
65MP0003890_abnormal_embryonic-extraembry1.01398788
66MP0002735_abnormal_chemical_nociception0.99033141
67MP0004883_abnormal_blood_vessel0.97950973
68MP0003633_abnormal_nervous_system0.96632495
69MP0000465_gastrointestinal_hemorrhage0.95030269
70MP0008058_abnormal_DNA_repair0.93818315
71MP0005647_abnormal_sex_gland0.92995587
72MP0005187_abnormal_penis_morphology0.92430918
73MP0002557_abnormal_social/conspecific_i0.91830322
74MP0001346_abnormal_lacrimal_gland0.91492608
75MP0002102_abnormal_ear_morphology0.91234757
76MP0001664_abnormal_digestion0.89991003
77MP0004742_abnormal_vestibular_system0.89279557
78MP0004145_abnormal_muscle_electrophysio0.88691472
79MP0003045_fibrosis0.88240773
80MP0005636_abnormal_mineral_homeostasis0.87855265
81MP0004133_heterotaxia0.87646608
82MP0003329_amyloid_beta_deposits0.87613924
83MP0003879_abnormal_hair_cell0.87424974
84MP0005253_abnormal_eye_physiology0.84742717
85MP0005164_abnormal_response_to0.84165826
86MP0004233_abnormal_muscle_weight0.83350938
87MP0000631_abnormal_neuroendocrine_gland0.83336928
88MP0002229_neurodegeneration0.83060174
89MP0001905_abnormal_dopamine_level0.82812965
90MP0001986_abnormal_taste_sensitivity0.80486696
91MP0006276_abnormal_autonomic_nervous0.80239972
92MP0004142_abnormal_muscle_tone0.79722325
93MP0002249_abnormal_larynx_morphology0.79406276
94MP0002882_abnormal_neuron_morphology0.78187046
95MP0003631_nervous_system_phenotype0.78118423
96MP0004484_altered_response_of0.76952108
97MP0002152_abnormal_brain_morphology0.76345140
98MP0001879_abnormal_lymphatic_vessel0.75716393
99MP0003938_abnormal_ear_development0.74455500
100MP0004043_abnormal_pH_regulation0.72687709
101MP0002876_abnormal_thyroid_physiology0.72530110
102MP0001963_abnormal_hearing_physiology0.72507725
103MP0004134_abnormal_chest_morphology0.72446565
104MP0005670_abnormal_white_adipose0.71772476
105MP0008872_abnormal_physiological_respon0.71182267
106MP0002295_abnormal_pulmonary_circulatio0.70821389
107MP0002752_abnormal_somatic_nervous0.70514726
108MP0002837_dystrophic_cardiac_calcinosis0.70214241
109MP0003634_abnormal_glial_cell0.70132354
110MP0003632_abnormal_nervous_system0.69049552
111MP0002909_abnormal_adrenal_gland0.68603636
112MP0000955_abnormal_spinal_cord0.67993607
113MP0002066_abnormal_motor_capabilities/c0.67834526
114MP0002928_abnormal_bile_duct0.67280127
115MP0001502_abnormal_circadian_rhythm0.65402636
116MP0006072_abnormal_retinal_apoptosis0.65034129
117MP0002822_catalepsy0.64819242
118MP0005195_abnormal_posterior_eye0.64341762
119MP0001970_abnormal_pain_threshold0.63923833
120MP0005503_abnormal_tendon_morphology0.63626588
121MP0008569_lethality_at_weaning0.63392764
122MP0004811_abnormal_neuron_physiology0.63375178
123MP0000462_abnormal_digestive_system0.63057993
124MP0005377_hearing/vestibular/ear_phenot0.61813701
125MP0003878_abnormal_ear_physiology0.61813701
126MP0004085_abnormal_heartbeat0.61489081
127MP0005389_reproductive_system_phenotype0.61449309
128MP0006292_abnormal_olfactory_placode0.61325103
129MP0002184_abnormal_innervation0.60867213
130MP0005386_behavior/neurological_phenoty0.60390565
131MP0004924_abnormal_behavior0.60390565
132MP0008057_abnormal_DNA_replication0.60371628
133MP0000920_abnormal_myelination0.60088675
134MP0001324_abnormal_eye_pigmentation0.60013371
135MP0000026_abnormal_inner_ear0.59660817
136MP0004036_abnormal_muscle_relaxation0.58779628
137MP0001293_anophthalmia0.58395124
138MP0000681_abnormal_thyroid_gland0.58244116
139MP0005391_vision/eye_phenotype0.57902138
140MP0001485_abnormal_pinna_reflex0.57852983
141MP0003718_maternal_effect0.57000016
142MP0003315_abnormal_perineum_morphology0.56733748
143MP0003011_delayed_dark_adaptation0.55851551
144MP0005409_darkened_coat_color0.55710097
145MP0000343_altered_response_to0.55463534
146MP0003942_abnormal_urinary_system0.55204553
147MP0009765_abnormal_xenobiotic_induced0.53805998
148MP0002136_abnormal_kidney_physiology0.53618245
149MP0003861_abnormal_nervous_system0.53608205
150MP0000427_abnormal_hair_cycle0.51843906
151MP0001756_abnormal_urination0.51540341
152MP0009780_abnormal_chondrocyte_physiolo0.51291231
153MP0003936_abnormal_reproductive_system0.49901721
154MP0005165_increased_susceptibility_to0.48289379
155MP0001270_distended_abdomen0.47982141

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.80504588
2Abnormal ciliary motility (HP:0012262)8.65823935
3Abnormal respiratory motile cilium morphology (HP:0005938)8.27118203
4Abnormal respiratory epithelium morphology (HP:0012253)8.27118203
5Rhinitis (HP:0012384)8.08007942
6Chronic bronchitis (HP:0004469)6.62609973
7Nasal polyposis (HP:0100582)5.04458303
8Infertility (HP:0000789)4.96453973
9Nephronophthisis (HP:0000090)4.79304587
10Bronchiectasis (HP:0002110)4.65020191
11Abnormality of the nasal mucosa (HP:0000433)4.04543025
12Bronchitis (HP:0012387)3.99640430
13Tubulointerstitial nephritis (HP:0001970)3.87293959
14Abnormality of the renal medulla (HP:0100957)3.84052921
15Medial flaring of the eyebrow (HP:0010747)3.70836409
16Molar tooth sign on MRI (HP:0002419)3.26967814
17Abnormality of midbrain morphology (HP:0002418)3.26967814
18Recurrent sinusitis (HP:0011108)3.20725387
19Pancreatic fibrosis (HP:0100732)3.12285830
20Chronic otitis media (HP:0000389)3.09634088
21Recurrent otitis media (HP:0000403)3.00335741
22Atelectasis (HP:0100750)2.94865422
23Tubulointerstitial abnormality (HP:0001969)2.74873038
24Gait imbalance (HP:0002141)2.68844659
25Congenital hepatic fibrosis (HP:0002612)2.64952262
26Congenital primary aphakia (HP:0007707)2.64208839
27True hermaphroditism (HP:0010459)2.63907282
28Male infertility (HP:0003251)2.59738192
29Postaxial foot polydactyly (HP:0001830)2.58920438
30Fibular hypoplasia (HP:0003038)2.51891056
31Tubular atrophy (HP:0000092)2.43165316
32Nephrogenic diabetes insipidus (HP:0009806)2.37307202
33Aplasia/Hypoplasia of the tongue (HP:0010295)2.27227176
34Chronic sinusitis (HP:0011109)2.25505293
35Recurrent bronchitis (HP:0002837)2.24327401
36Stage 5 chronic kidney disease (HP:0003774)2.23217468
37Abnormal spermatogenesis (HP:0008669)2.21917293
38Genital tract atresia (HP:0001827)2.20229284
39Cystic liver disease (HP:0006706)2.16422411
40Hyperactive renin-angiotensin system (HP:0000841)2.14737280
41Abnormality of the lower motor neuron (HP:0002366)2.11389119
42Median cleft lip (HP:0000161)2.10689071
43Postaxial hand polydactyly (HP:0001162)2.09413572
44Microglossia (HP:0000171)2.08547190
45Pancreatic cysts (HP:0001737)2.07663491
46Vaginal atresia (HP:0000148)2.06350963
47Polydipsia (HP:0001959)2.02773568
48Abnormal drinking behavior (HP:0030082)2.02773568
49Abnormality of the renal cortex (HP:0011035)2.02702450
50Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.3904254
51Absent/shortened dynein arms (HP:0200106)10.8239155
52Dynein arm defect of respiratory motile cilia (HP:0012255)10.8239155
53Occipital encephalocele (HP:0002085)1.96758921
54Poor coordination (HP:0002370)1.96598037
55Supernumerary spleens (HP:0009799)1.93808242
56J-shaped sella turcica (HP:0002680)1.93091796
57Abnormal biliary tract physiology (HP:0012439)1.91789121
58Bile duct proliferation (HP:0001408)1.91789121
59Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88848452
60Gonadotropin excess (HP:0000837)1.88041503
61Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.87824325
62Degeneration of the lateral corticospinal tracts (HP:0002314)1.87824325
63Abnormality of permanent molar morphology (HP:0011071)1.86873312
64Abnormality of the dental root (HP:0006486)1.86873312
65Taurodontia (HP:0000679)1.86873312
66Chronic hepatic failure (HP:0100626)1.86662232
67Aplasia/Hypoplasia of the lens (HP:0008063)1.85933143
68Oculomotor apraxia (HP:0000657)1.84421893
69Amyotrophic lateral sclerosis (HP:0007354)1.83283988
70Abnormality of dentin (HP:0010299)1.81370635
71Tubulointerstitial fibrosis (HP:0005576)1.79034970
72Abnormality of molar morphology (HP:0011070)1.77857825
73Abnormality of molar (HP:0011077)1.77857825
74Decreased central vision (HP:0007663)1.77019275
75Furrowed tongue (HP:0000221)1.75872472
76Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.72485981
77Renal dysplasia (HP:0000110)1.72350128
78Azoospermia (HP:0000027)1.71013798
79Abnormality of the dental pulp (HP:0006479)1.68642908
80Focal motor seizures (HP:0011153)1.61306311
81Aplasia/Hypoplasia of the fibula (HP:0006492)1.61146654
82Facial cleft (HP:0002006)1.59421904
83Gaze-evoked nystagmus (HP:0000640)1.59135595
84Abnormal rod and cone electroretinograms (HP:0008323)1.55825276
85Short ribs (HP:0000773)1.54695766
86Epileptic encephalopathy (HP:0200134)1.52523482
87Retinal dysplasia (HP:0007973)1.50646621
88Impaired proprioception (HP:0010831)1.49835571
89Preaxial hand polydactyly (HP:0001177)1.48074075
90Absent frontal sinuses (HP:0002688)1.48014229
91Hemiparesis (HP:0001269)1.47377142
92Abnormality of the frontal sinuses (HP:0002687)1.46325188
93Anencephaly (HP:0002323)1.45967560
94Abnormality of renal excretion (HP:0011036)1.44911503
95Bell-shaped thorax (HP:0001591)1.42775288
96Neurofibrillary tangles (HP:0002185)1.38390021
97Nephropathy (HP:0000112)1.37048488
98Abnormality of saccadic eye movements (HP:0000570)1.36848396
99Male pseudohermaphroditism (HP:0000037)1.35215245
100Sclerocornea (HP:0000647)1.33809085
101Dyschromatopsia (HP:0007641)1.33616117
102Decreased circulating renin level (HP:0003351)1.33594510
103Renal salt wasting (HP:0000127)1.32367547
104Abnormality of ocular smooth pursuit (HP:0000617)1.32280026
105Retinitis pigmentosa (HP:0000510)1.31499056
106Cone-rod dystrophy (HP:0000548)1.30640790
107Short tibia (HP:0005736)1.29233675
108Absent speech (HP:0001344)1.27980614
109Hyperkalemia (HP:0002153)1.26999497
110Abnormality of the corticospinal tract (HP:0002492)1.26929190
111Prolonged bleeding time (HP:0003010)1.26715295
112Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.26245885
113Short thorax (HP:0010306)1.26108683
114Polyuria (HP:0000103)1.24705370
115Asplenia (HP:0001746)1.24622856
116Astigmatism (HP:0000483)1.24537035
117Ventricular fibrillation (HP:0001663)1.24208782
118Aplasia/Hypoplasia of the spleen (HP:0010451)1.24054838
119Short nail (HP:0001799)1.22840558
120Bony spicule pigmentary retinopathy (HP:0007737)1.18106452
121Purpura (HP:0000979)1.17926301
122Aganglionic megacolon (HP:0002251)1.16711663
123Muscle fiber splitting (HP:0003555)1.15806957
124Prominent nasal bridge (HP:0000426)1.13722422
125Multicystic kidney dysplasia (HP:0000003)1.11210312
126Hypoplasia of the uterus (HP:0000013)1.10611260
127Menorrhagia (HP:0000132)1.08255515
128Bifid scrotum (HP:0000048)1.06453879
129Broad foot (HP:0001769)1.05540374

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.57698199
2PDK37.57698199
3PDK24.83068644
4MST44.77518352
5PNCK3.60642495
6STK393.24451295
7PTK2B3.16115519
8WNK42.58218851
9PRKD32.53310961
10TESK12.40736887
11FRK2.30686102
12MYLK2.29937260
13MAPK152.29585047
14EPHA22.24128765
15CASK2.22727998
16MAP2K72.08202998
17EPHA41.91023126
18TNIK1.80547568
19ICK1.75473207
20STK241.74214837
21NTRK31.66432236
22STK381.61265670
23TLK11.58063722
24MARK31.51528283
25MAP3K21.42862027
26MAP3K41.40415121
27LATS11.38314209
28MAPKAPK31.37720176
29NLK1.29347250
30EPHA31.28923576
31BCR1.24548000
32OXSR11.15678742
33WNK11.12098733
34RIPK41.11020180
35FGFR21.09417822
36SGK21.01227379
37NEK61.00975899
38MUSK1.00948461
39CCNB10.96735251
40MAP3K30.90501080
41DYRK30.87994155
42PDK10.87304846
43BMX0.86770816
44STK160.85283154
45BMPR1B0.83093327
46NTRK20.82769448
47PRKCG0.82171103
48ERBB20.81192656
49MAP3K50.81067394
50EIF2AK10.80786135
51GRK60.78265893
52CDK30.78050385
53ACVR1B0.77672944
54NME10.76159612
55TYRO30.74108460
56BRSK20.73161469
57ADRBK10.71228069
58CAMK2A0.70475382
59TRPM70.69993491
60RET0.69002332
61CSK0.67910769
62NEK20.66880990
63EPHB10.65963003
64ERBB30.64622227
65MKNK20.64431967
66IRAK10.61918283
67PLK20.59877590
68MAPK130.56476975
69BMPR20.56344723
70CAMK1G0.56063925
71MAP2K40.55594953
72PAK30.55390371
73MAP3K130.55163521
74MARK10.53529748
75ROCK10.53183910
76MAP3K120.52929596
77PKN10.52338545
78ILK0.51836130
79CAMK2B0.51262579
80PDPK10.51240450
81CHEK20.50596016
82WNK30.48665326
83LRRK20.48153681
84MAP4K20.47662252
85SGK30.47529992
86YES10.47025500
87NEK90.46681393
88RPS6KA50.46532324
89LMTK20.46499710
90STK38L0.45910074
91MARK20.45794873
92PINK10.45498126
93PRKCQ0.45024144
94GRK10.44633505
95STK30.44320934
96GRK70.42821825
97MINK10.42132789
98CAMKK20.41590938
99STK40.41424174
100FGR0.41393557
101AKT30.40560568
102TEC0.40522207
103MST1R0.40002398
104GRK50.39612522
105FES0.38586654
106INSRR0.37359919
107MOS0.36876946
108CDK50.36581611
109PAK60.36525708
110PRKG10.36478418
111WEE10.36424698
112STK100.36033483
113BTK0.34899537
114TTK0.34802778
115PRKCE0.34550369
116BRAF0.34319884
117MAPKAPK50.34148726
118FGFR30.32638613
119CDK190.31712689
120FER0.30910596
121MAP3K70.30673732
122CAMK2D0.30536457
123SIK20.29650711
124MET0.29152939
125TAOK10.27792063
126CAMKK10.27414383
127SGK4940.27341520
128SGK2230.27341520
129PRKCI0.26197851
130DYRK1A0.26051719
131PRKACA0.25618369
132PRKCD0.25310117
133ATM0.24929259
134CHEK10.24017412
135DYRK1B0.21970657
136AKT20.21665565
137RPS6KB10.19601875
138PHKG10.18250700
139PHKG20.18250700
140ADRBK20.17947441
141MAPK100.17751187
142SGK10.17488215
143CAMK10.17450769
144PRKAA20.17307237
145PRKCA0.16815523
146MAP3K60.16696296
147PRKACB0.16542710
148PRKCB0.16451306
149STK110.16079623
150CAMK2G0.15165092
151PRKCZ0.15150887
152GSK3B0.13229701
153PRKDC0.13203978
154PAK10.12858738
155ROCK20.12324343
156DAPK20.12310274

Predicted pathways (KEGG)

RankGene SetZ-score
1Chemical carcinogenesis_Homo sapiens_hsa052043.75052208
2Vitamin B6 metabolism_Homo sapiens_hsa007503.50405673
3Phenylalanine metabolism_Homo sapiens_hsa003603.00598895
4Nicotine addiction_Homo sapiens_hsa050332.94462113
5Pyruvate metabolism_Homo sapiens_hsa006202.88926719
6beta-Alanine metabolism_Homo sapiens_hsa004102.72439166
7Histidine metabolism_Homo sapiens_hsa003402.71288636
8Tyrosine metabolism_Homo sapiens_hsa003502.56037574
9Huntingtons disease_Homo sapiens_hsa050162.46948985
10Amphetamine addiction_Homo sapiens_hsa050312.40996181
11Glutathione metabolism_Homo sapiens_hsa004802.28575432
12Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.20209159
13Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.14217143
14Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.11762630
15Taste transduction_Homo sapiens_hsa047422.11599733
16Propanoate metabolism_Homo sapiens_hsa006402.10917802
17Fatty acid biosynthesis_Homo sapiens_hsa000612.05995455
18Dorso-ventral axis formation_Homo sapiens_hsa043202.01814590
19Glucagon signaling pathway_Homo sapiens_hsa049222.00248617
20Renin secretion_Homo sapiens_hsa049241.98206548
21Glutamatergic synapse_Homo sapiens_hsa047241.93762915
22Nitrogen metabolism_Homo sapiens_hsa009101.91529852
23Circadian entrainment_Homo sapiens_hsa047131.88598372
24Retinol metabolism_Homo sapiens_hsa008301.88309031
25Basal transcription factors_Homo sapiens_hsa030221.85190058
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.82562216
27Long-term potentiation_Homo sapiens_hsa047201.78389737
28Olfactory transduction_Homo sapiens_hsa047401.75747687
29Morphine addiction_Homo sapiens_hsa050321.75634474
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.75465367
31Hedgehog signaling pathway_Homo sapiens_hsa043401.75282626
32Fanconi anemia pathway_Homo sapiens_hsa034601.75147032
33Cardiac muscle contraction_Homo sapiens_hsa042601.73396942
34Calcium signaling pathway_Homo sapiens_hsa040201.65729749
35Linoleic acid metabolism_Homo sapiens_hsa005911.65578374
36Collecting duct acid secretion_Homo sapiens_hsa049661.61861310
37Caffeine metabolism_Homo sapiens_hsa002321.59395659
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.58466224
39Pentose phosphate pathway_Homo sapiens_hsa000301.49937103
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.49403214
41Phototransduction_Homo sapiens_hsa047441.48868502
42Salivary secretion_Homo sapiens_hsa049701.48570837
43Ether lipid metabolism_Homo sapiens_hsa005651.47792893
44Gap junction_Homo sapiens_hsa045401.45407632
45Synaptic vesicle cycle_Homo sapiens_hsa047211.43191729
46Oocyte meiosis_Homo sapiens_hsa041141.40709494
47Insulin secretion_Homo sapiens_hsa049111.40560254
48GABAergic synapse_Homo sapiens_hsa047271.36593170
49Dopaminergic synapse_Homo sapiens_hsa047281.32099357
50Circadian rhythm_Homo sapiens_hsa047101.30777479
51Cocaine addiction_Homo sapiens_hsa050301.28772633
52Oxidative phosphorylation_Homo sapiens_hsa001901.27260565
53Glycerolipid metabolism_Homo sapiens_hsa005611.25367814
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25304293
55Glycerophospholipid metabolism_Homo sapiens_hsa005641.19048593
56Gastric acid secretion_Homo sapiens_hsa049711.18003145
57Butanoate metabolism_Homo sapiens_hsa006501.17805758
58Tight junction_Homo sapiens_hsa045301.15494758
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15013197
60SNARE interactions in vesicular transport_Homo sapiens_hsa041301.11050911
61Carbohydrate digestion and absorption_Homo sapiens_hsa049731.10248868
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09966895
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.08425844
64Alzheimers disease_Homo sapiens_hsa050101.07407944
65cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03841626
66Peroxisome_Homo sapiens_hsa041461.03416113
67Serotonergic synapse_Homo sapiens_hsa047261.01918491
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01331660
69cAMP signaling pathway_Homo sapiens_hsa040241.00142778
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99492484
71Fatty acid degradation_Homo sapiens_hsa000710.99072688
72Mineral absorption_Homo sapiens_hsa049780.99053885
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98212183
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.94164598
75Oxytocin signaling pathway_Homo sapiens_hsa049210.88773420
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.88708088
77Regulation of autophagy_Homo sapiens_hsa041400.87910139
78Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84736862
79Aldosterone synthesis and secretion_Homo sapiens_hsa049250.84411779
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84205867
81Choline metabolism in cancer_Homo sapiens_hsa052310.83861317
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.83101441
83Estrogen signaling pathway_Homo sapiens_hsa049150.82155646
84Purine metabolism_Homo sapiens_hsa002300.81251073
85Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79521755
86Platelet activation_Homo sapiens_hsa046110.76231005
87Starch and sucrose metabolism_Homo sapiens_hsa005000.75360558
88Pancreatic secretion_Homo sapiens_hsa049720.74291391
89Basal cell carcinoma_Homo sapiens_hsa052170.69453880
90Cholinergic synapse_Homo sapiens_hsa047250.68427594
91ECM-receptor interaction_Homo sapiens_hsa045120.66800728
92Axon guidance_Homo sapiens_hsa043600.66163628
93Parkinsons disease_Homo sapiens_hsa050120.63153647
94Long-term depression_Homo sapiens_hsa047300.61837887
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61796657
96Phagosome_Homo sapiens_hsa041450.61385049
97Arachidonic acid metabolism_Homo sapiens_hsa005900.61105824
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.59735208
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59476874
100PPAR signaling pathway_Homo sapiens_hsa033200.59318864
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.59071122
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58813249
103mRNA surveillance pathway_Homo sapiens_hsa030150.56838127
104Renin-angiotensin system_Homo sapiens_hsa046140.56779263
105Thyroid hormone synthesis_Homo sapiens_hsa049180.56215139
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53637342
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52072203
108Carbon metabolism_Homo sapiens_hsa012000.51414816
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51153212
110Inositol phosphate metabolism_Homo sapiens_hsa005620.50858935
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.50293283
112Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50021568
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50005727
114Sphingolipid metabolism_Homo sapiens_hsa006000.49134379
115Non-homologous end-joining_Homo sapiens_hsa034500.48861422
116Notch signaling pathway_Homo sapiens_hsa043300.48307480
117Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48178309
118Complement and coagulation cascades_Homo sapiens_hsa046100.47467633
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46668619
120Fatty acid elongation_Homo sapiens_hsa000620.46322647
121Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45168446
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44334691
123Vibrio cholerae infection_Homo sapiens_hsa051100.43249139
124ABC transporters_Homo sapiens_hsa020100.42154165
125Fructose and mannose metabolism_Homo sapiens_hsa000510.40399529
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39936696
127Fatty acid metabolism_Homo sapiens_hsa012120.39730635
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39185252
129Wnt signaling pathway_Homo sapiens_hsa043100.38246153
130TGF-beta signaling pathway_Homo sapiens_hsa043500.37515683
131Adherens junction_Homo sapiens_hsa045200.36781073
132Drug metabolism - other enzymes_Homo sapiens_hsa009830.36490972
133Metabolic pathways_Homo sapiens_hsa011000.35785165
134Type II diabetes mellitus_Homo sapiens_hsa049300.35649914
135Hippo signaling pathway_Homo sapiens_hsa043900.35619088
136Ovarian steroidogenesis_Homo sapiens_hsa049130.35423898
137Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32912040
138Steroid biosynthesis_Homo sapiens_hsa001000.30487138
139Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30049517
140MAPK signaling pathway_Homo sapiens_hsa040100.29835138
141Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29540046
142Rheumatoid arthritis_Homo sapiens_hsa053230.29242896
143Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.28923778
144Alcoholism_Homo sapiens_hsa050340.28188581
145Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28161277
146Selenocompound metabolism_Homo sapiens_hsa004500.27265859
147Hematopoietic cell lineage_Homo sapiens_hsa046400.27095269
148Prostate cancer_Homo sapiens_hsa052150.25293854
149Dilated cardiomyopathy_Homo sapiens_hsa054140.24633579
150Melanogenesis_Homo sapiens_hsa049160.24532265

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