BBOX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes gamma butyrobetaine hydroxylase which catalyzes the formation of L-carnitine from gamma-butyrobetaine, the last step in the L-carnitine biosynthetic pathway. Carnitine is essential for the transport of activated fatty acids across the mitochondrial membrane during mitochondrial beta-oxidation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.36204306
2L-phenylalanine catabolic process (GO:0006559)7.36204306
3L-phenylalanine metabolic process (GO:0006558)7.00273323
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.00273323
5aromatic amino acid family catabolic process (GO:0009074)6.65083321
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.45211714
7exogenous drug catabolic process (GO:0042738)6.39912803
8tryptophan catabolic process (GO:0006569)6.02347610
9indole-containing compound catabolic process (GO:0042436)6.02347610
10indolalkylamine catabolic process (GO:0046218)6.02347610
11bile acid biosynthetic process (GO:0006699)5.96449318
12kynurenine metabolic process (GO:0070189)5.89435158
13tryptophan metabolic process (GO:0006568)5.66670817
14high-density lipoprotein particle remodeling (GO:0034375)5.62682012
15glyoxylate metabolic process (GO:0046487)5.60283284
16urea metabolic process (GO:0019627)5.52055758
17urea cycle (GO:0000050)5.52055758
18alpha-linolenic acid metabolic process (GO:0036109)5.47766627
19negative regulation of fibrinolysis (GO:0051918)5.41180680
20cysteine metabolic process (GO:0006534)5.35223838
21epoxygenase P450 pathway (GO:0019373)5.34760125
22peptidyl-glutamic acid carboxylation (GO:0017187)5.34708857
23protein carboxylation (GO:0018214)5.34708857
24response to mercury ion (GO:0046689)5.31760398
25regulation of fibrinolysis (GO:0051917)5.30165181
26sulfur amino acid catabolic process (GO:0000098)5.26148116
27regulation of protein activation cascade (GO:2000257)5.18826792
28complement activation, alternative pathway (GO:0006957)5.16017433
29serine family amino acid catabolic process (GO:0009071)5.11776115
30omega-hydroxylase P450 pathway (GO:0097267)5.10051879
31bile acid metabolic process (GO:0008206)5.08315542
32nitrogen cycle metabolic process (GO:0071941)5.06202534
33regulation of cholesterol esterification (GO:0010872)4.96396357
34regulation of triglyceride catabolic process (GO:0010896)4.94198788
35reverse cholesterol transport (GO:0043691)4.89612748
36plasma lipoprotein particle remodeling (GO:0034369)4.86557642
37protein-lipid complex remodeling (GO:0034368)4.86557642
38macromolecular complex remodeling (GO:0034367)4.86557642
39regulation of complement activation (GO:0030449)4.85523120
40fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.81060248
41aromatic amino acid family metabolic process (GO:0009072)4.80478490
42phospholipid efflux (GO:0033700)4.78576976
43homocysteine metabolic process (GO:0050667)4.71036797
44tyrosine metabolic process (GO:0006570)4.64329062
45negative regulation of sterol transport (GO:0032372)4.59715759
46negative regulation of cholesterol transport (GO:0032375)4.59715759
47acylglycerol homeostasis (GO:0055090)4.58592058
48triglyceride homeostasis (GO:0070328)4.58592058
49alpha-amino acid catabolic process (GO:1901606)4.56821842
50* amino-acid betaine metabolic process (GO:0006577)4.56806872
51bile acid and bile salt transport (GO:0015721)4.36746511
52lysine metabolic process (GO:0006553)4.36605041
53lysine catabolic process (GO:0006554)4.36605041
54glycine metabolic process (GO:0006544)4.35635008
55cellular glucuronidation (GO:0052695)4.34027462
56cellular ketone body metabolic process (GO:0046950)4.33211151
57imidazole-containing compound metabolic process (GO:0052803)4.32479823
58plasma lipoprotein particle clearance (GO:0034381)4.30969666
59ethanol oxidation (GO:0006069)4.27360395
60cellular biogenic amine catabolic process (GO:0042402)4.27215346
61amine catabolic process (GO:0009310)4.27215346
62coenzyme catabolic process (GO:0009109)4.26532621
63indolalkylamine metabolic process (GO:0006586)4.25754653
64drug metabolic process (GO:0017144)4.25106038
65cholesterol efflux (GO:0033344)4.22776513
66low-density lipoprotein particle remodeling (GO:0034374)4.20909032
67cellular amino acid catabolic process (GO:0009063)4.19432475
68fibrinolysis (GO:0042730)4.16369877
69glutamate metabolic process (GO:0006536)4.13051152
70serine family amino acid metabolic process (GO:0009069)4.12082522
71negative regulation of lipase activity (GO:0060192)4.06106112
72benzene-containing compound metabolic process (GO:0042537)4.03411203
73cellular modified amino acid catabolic process (GO:0042219)4.01183438
74ethanol metabolic process (GO:0006067)3.99217745
75plasma lipoprotein particle assembly (GO:0034377)3.95432656
76arginine metabolic process (GO:0006525)3.92314431
77drug catabolic process (GO:0042737)3.90959799
78dicarboxylic acid biosynthetic process (GO:0043650)3.87559798
79oxidative demethylation (GO:0070989)3.86522144
80uronic acid metabolic process (GO:0006063)3.84994532
81glucuronate metabolic process (GO:0019585)3.84994532
82positive regulation of lipid catabolic process (GO:0050996)3.81196422
83blood coagulation, intrinsic pathway (GO:0007597)3.78886485
84serine family amino acid biosynthetic process (GO:0009070)3.76124945
85short-chain fatty acid metabolic process (GO:0046459)3.75841987
86aldehyde catabolic process (GO:0046185)3.75320386
87ketone body metabolic process (GO:1902224)3.74663830
88cholesterol homeostasis (GO:0042632)3.73765047
89regulation of bile acid biosynthetic process (GO:0070857)3.73329209
90positive regulation of lipoprotein lipase activity (GO:0051006)3.72156266
91positive regulation of triglyceride lipase activity (GO:0061365)3.72156266
92very-low-density lipoprotein particle assembly (GO:0034379)3.70905069
93phenylpropanoid metabolic process (GO:0009698)3.70712899
94protein activation cascade (GO:0072376)3.69225646
95organic acid catabolic process (GO:0016054)3.68913958
96carboxylic acid catabolic process (GO:0046395)3.68913958
97S-adenosylmethionine metabolic process (GO:0046500)3.68243060
98sterol homeostasis (GO:0055092)3.67060779
99complement activation, classical pathway (GO:0006958)3.66546294
100plasma lipoprotein particle organization (GO:0071827)3.65718986
101complement activation (GO:0006956)3.65210682
102cofactor catabolic process (GO:0051187)3.64439880
103phospholipid homeostasis (GO:0055091)3.62646985
104regulation of cholesterol homeostasis (GO:2000188)3.62225945
105acetyl-CoA metabolic process (GO:0006084)3.60523206
106axon ensheathment in central nervous system (GO:0032291)3.53690577
107central nervous system myelination (GO:0022010)3.53690577
108cytolysis (GO:0019835)3.53148918
109fat-soluble vitamin biosynthetic process (GO:0042362)3.51913700
110protein-lipid complex assembly (GO:0065005)3.49743303
111positive regulation of fatty acid beta-oxidation (GO:0032000)3.46654836
112flavonoid metabolic process (GO:0009812)3.46584077
113aminoglycoside antibiotic metabolic process (GO:0030647)3.44199356
114primary alcohol catabolic process (GO:0034310)3.39950760
115negative regulation of blood coagulation (GO:0030195)3.27312786
116negative regulation of hemostasis (GO:1900047)3.27312786
117L-methionine salvage (GO:0071267)3.22164365
118L-methionine biosynthetic process (GO:0071265)3.22164365
119amino acid salvage (GO:0043102)3.22164365
120regulation of plasminogen activation (GO:0010755)3.21355918
121sodium-independent organic anion transport (GO:0043252)3.09707936
122opsonization (GO:0008228)3.07783291
123negative regulation of wound healing (GO:0061045)2.98171849
124negative regulation of coagulation (GO:0050819)2.97308781
125response to auditory stimulus (GO:0010996)2.94370278
126regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.93604509
127negative regulation of protein activation cascade (GO:2000258)2.92083848
128steroid catabolic process (GO:0006706)2.90276680
129primary alcohol metabolic process (GO:0034308)2.86768920
130alkaloid metabolic process (GO:0009820)2.85368238
131daunorubicin metabolic process (GO:0044597)2.85299565
132polyketide metabolic process (GO:0030638)2.85299565
133doxorubicin metabolic process (GO:0044598)2.85299565
134regulation of cholesterol biosynthetic process (GO:0045540)2.81591331
135monocarboxylic acid catabolic process (GO:0072329)2.76250518
136astrocyte differentiation (GO:0048708)2.76105020
137xenobiotic catabolic process (GO:0042178)2.74569593
138xenobiotic metabolic process (GO:0006805)2.74133574
139heme transport (GO:0015886)2.72573678
140negative regulation of complement activation (GO:0045916)2.69532493
141postsynaptic membrane organization (GO:0001941)2.69363584
142pyrimidine nucleobase catabolic process (GO:0006208)2.67492437
143L-amino acid import (GO:0043092)2.67175898
144very long-chain fatty acid metabolic process (GO:0000038)2.64757868

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.95544777
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.85787276
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.78741673
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.20688636
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.11949160
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.70688269
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.58933751
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.82068545
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.57135606
10EZH2_22144423_ChIP-Seq_EOC_Human2.85033137
11GBX2_23144817_ChIP-Seq_PC3_Human2.70450302
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.32707947
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.07227192
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.3603706
15CDX2_19796622_ChIP-Seq_MESCs_Mouse1.93536205
16TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.88663478
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.87991479
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.82513570
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69681338
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.64111695
21GATA1_22025678_ChIP-Seq_K562_Human1.61126913
22HTT_18923047_ChIP-ChIP_STHdh_Human1.60656474
23* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59318943
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.59158385
25TP53_18474530_ChIP-ChIP_U2OS_Human1.54115444
26* FOXA2_19822575_ChIP-Seq_HepG2_Human1.48020218
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.45454120
28CLOCK_20551151_ChIP-Seq_293T_Human1.44861234
29* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40498753
30MTF2_20144788_ChIP-Seq_MESCs_Mouse1.38259962
31SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.35963198
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.35538067
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32782404
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.31817529
35SMAD4_21799915_ChIP-Seq_A2780_Human1.30719789
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29743556
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29604786
38RNF2_18974828_ChIP-Seq_MESCs_Mouse1.26405443
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.26405443
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.25989993
41* HNF4A_19822575_ChIP-Seq_HepG2_Human1.25966049
42PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.24758928
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23295897
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19964951
45* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19448536
46* EP300_21415370_ChIP-Seq_HL-1_Mouse1.19102638
47AR_21572438_ChIP-Seq_LNCaP_Human1.17054850
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16770139
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16627401
50* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15378577
51RXRA_24833708_ChIP-Seq_LIVER_Mouse1.12211406
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11873697
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.10131529
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06550935
55RNF2_27304074_Chip-Seq_ESCs_Mouse1.06275698
56TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06244551
57DROSHA_22980978_ChIP-Seq_HELA_Human1.05928960
58JARID2_20064375_ChIP-Seq_MESCs_Mouse1.05653346
59TP53_16413492_ChIP-PET_HCT116_Human1.05484873
60EED_16625203_ChIP-ChIP_MESCs_Mouse1.04205054
61* SMAD3_21741376_ChIP-Seq_EPCs_Human1.04120307
62* NANOG_18555785_Chip-Seq_ESCs_Mouse1.02645761
63P300_19829295_ChIP-Seq_ESCs_Human1.02396307
64CJUN_26792858_Chip-Seq_BT549_Human1.01930761
65* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01551758
66REST_21632747_ChIP-Seq_MESCs_Mouse1.00163582
67* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98369348
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98359467
69SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97810199
70STAT3_23295773_ChIP-Seq_U87_Human0.97587345
71ESR2_21235772_ChIP-Seq_MCF-7_Human0.97428924
72TCF4_22108803_ChIP-Seq_LS180_Human0.96952796
73E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.96602157
74JARID2_20075857_ChIP-Seq_MESCs_Mouse0.96391671
75BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95815293
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94778500
77* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94692649
78GATA4_25053715_ChIP-Seq_YYC3_Human0.94137160
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93822684
80AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93431248
81NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92735687
82ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92555530
83IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.91174377
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91159633
85* AR_25329375_ChIP-Seq_VCAP_Human0.89555645
86SMAD3_21741376_ChIP-Seq_HESCs_Human0.88596736
87SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.88508862
88* P53_22387025_ChIP-Seq_ESCs_Mouse0.88415047
89MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88179875
90EZH2_27304074_Chip-Seq_ESCs_Mouse0.87764656
91SMAD4_21741376_ChIP-Seq_HESCs_Human0.87046978
92P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86770246
93* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86740996
94ZNF263_19887448_ChIP-Seq_K562_Human0.86522961
95TAL1_26923725_Chip-Seq_HPCs_Mouse0.86281727
96ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86274110
97LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86147418
98CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85293958
99RARG_19884340_ChIP-ChIP_MEFs_Mouse0.85042490
100SOX2_21211035_ChIP-Seq_LN229_Gbm0.84810565
101AHR_22903824_ChIP-Seq_MCF-7_Human0.84677625
102ESR1_21235772_ChIP-Seq_MCF-7_Human0.84630111
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82723218
104BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.81779642
105ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81288381
106NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.80061275
107NRF2_20460467_ChIP-Seq_MEFs_Mouse0.80061275
108IRF8_22096565_ChIP-ChIP_GC-B_Human0.78581176
109KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77939277
110AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.74309282
111STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.73507604
112Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.72808605
113BCAT_22108803_ChIP-Seq_LS180_Human0.72120845
114SALL4_18804426_ChIP-ChIP_XEN_Mouse0.69827297
115CEBPB_22108803_ChIP-Seq_LS180_Human0.68678845
116CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.67737799
117FOXO3_23340844_ChIP-Seq_DLD1_Human0.67422052
118RAD21_21589869_ChIP-Seq_MESCs_Mouse0.67025294
119RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.64053534
120CDX2_20551321_ChIP-Seq_CACO-2_Human0.62880699
121RARA_24833708_ChIP-Seq_LIVER_Mouse0.59131234
122SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.58427596
123PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.58310672
124PPAR_26484153_Chip-Seq_NCI-H1993_Human0.57963958
125FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.57578095
126* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.57401590
127SOX2_20726797_ChIP-Seq_SW620_Human0.56812613
128TAF15_26573619_Chip-Seq_HEK293_Human0.55897684
129SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.55466958
130ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.54925587
131* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.54384580
132RARB_24833708_ChIP-Seq_LIVER_Mouse0.54068810
133* AR_20517297_ChIP-Seq_VCAP_Human0.53352545
134FOXA1_25552417_ChIP-Seq_VCAP_Human0.53322992
135EGR1_19032775_ChIP-ChIP_M12_Human0.52701571
136P53_21459846_ChIP-Seq_SAOS-2_Human0.52262680
137STAT1_17558387_ChIP-Seq_HELA_Human0.51021579
138CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.50427148
139CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.49893973
140LXR_22292898_ChIP-Seq_THP-1_Human0.49641227
141* MYC_19915707_ChIP-ChIP_AK7_Human0.49487017
142* CBP_21632823_ChIP-Seq_H3396_Human0.49429434
143FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49312764
144ERG_21242973_ChIP-ChIP_JURKAT_Human0.49170308
145NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.47257279
146* TP63_23658742_ChIP-Seq_EP156T_Human0.47147342
147FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.46980335
148PIAS1_25552417_ChIP-Seq_VCAP_Human0.46404460
149NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.46250413
150SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.45503837
151SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.45467804
152CDX2_22108803_ChIP-Seq_LS180_Human0.44886540
153ESR1_20079471_ChIP-ChIP_T-47D_Human0.43599424
154GATA3_24758297_ChIP-Seq_MCF-7_Human0.43555513
155ESET_19884257_ChIP-Seq_ESCs_Mouse0.43487339
156TAF2_19829295_ChIP-Seq_ESCs_Human0.42719884
157GATA6_25053715_ChIP-Seq_YYC3_Human0.42537165
158GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.42231905
159ZNF217_24962896_ChIP-Seq_MCF-7_Human0.42203134
160CRX_20693478_ChIP-Seq_RETINA_Mouse0.39759081
161MYC_27129775_Chip-Seq_CORNEA_Mouse0.39680899
162TRIM28_21343339_ChIP-Seq_HEK293_Human0.39470010
163IRF1_19129219_ChIP-ChIP_H3396_Human0.39020889
164FOXH1_21741376_ChIP-Seq_EPCs_Human0.38192906
165* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.38130856
166GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.37860474
167FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.37271165

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.10044337
2MP0005360_urolithiasis7.32368877
3MP0005085_abnormal_gallbladder_physiolo6.36922709
4MP0005365_abnormal_bile_salt5.99217290
5MP0008875_abnormal_xenobiotic_pharmacok5.06632065
6MP0003806_abnormal_nucleotide_metabolis3.94264218
7MP0003252_abnormal_bile_duct3.80891203
8MP0010329_abnormal_lipoprotein_level3.50447554
9MP0009840_abnormal_foam_cell3.30409903
10MP0003136_yellow_coat_color3.20985445
11MP0005083_abnormal_biliary_tract2.94365411
12MP0003195_calcinosis2.81304227
13MP0001666_abnormal_nutrient_absorption2.64917619
14MP0005332_abnormal_amino_acid2.59296161
15MP0004043_abnormal_pH_regulation2.53519488
16MP0004885_abnormal_endolymph2.27493030
17MP0005171_absent_coat_pigmentation2.25369254
18MP0004019_abnormal_vitamin_homeostasis2.18590616
19MP0003191_abnormal_cellular_cholesterol2.16269508
20MP0004859_abnormal_synaptic_plasticity2.05009856
21MP0000609_abnormal_liver_physiology2.03240156
22MP0002118_abnormal_lipid_homeostasis2.02938371
23MP0001984_abnormal_olfaction1.87199988
24MP0002638_abnormal_pupillary_reflex1.84966493
25MP0003011_delayed_dark_adaptation1.78160911
26MP0002138_abnormal_hepatobiliary_system1.74060248
27MP0003868_abnormal_feces_composition1.73331619
28MP0005451_abnormal_body_composition1.66644192
29MP0005319_abnormal_enzyme/_coenzyme1.63963797
30MP0002254_reproductive_system_inflammat1.62935216
31MP0001764_abnormal_homeostasis1.59091996
32MP0002796_impaired_skin_barrier1.56015194
33MP0009697_abnormal_copulation1.53404951
34MP0005584_abnormal_enzyme/coenzyme_acti1.45298832
35MP0003879_abnormal_hair_cell1.42105013
36MP0003183_abnormal_peptide_metabolism1.40623866
37MP0003880_abnormal_central_pattern1.40059585
38MP0000920_abnormal_myelination1.39899455
39MP0001486_abnormal_startle_reflex1.33778974
40MP0004270_analgesia1.32424594
41MP0002653_abnormal_ependyma_morphology1.30705883
42MP0005167_abnormal_blood-brain_barrier1.29967023
43MP0005423_abnormal_somatic_nervous1.26316605
44MP0005647_abnormal_sex_gland1.26039215
45MP0004381_abnormal_hair_follicle1.23205164
46MP0002064_seizures1.23105537
47MP0003705_abnormal_hypodermis_morpholog1.14727264
48MP0009643_abnormal_urine_homeostasis1.14184021
49MP0003186_abnormal_redox_activity1.12835714
50MP0003635_abnormal_synaptic_transmissio1.12808676
51MP0003632_abnormal_nervous_system1.12572721
52MP0002282_abnormal_trachea_morphology1.12187307
53MP0001502_abnormal_circadian_rhythm1.11702364
54MP0009764_decreased_sensitivity_to1.10669978
55MP0009745_abnormal_behavioral_response1.09608539
56MP0002063_abnormal_learning/memory/cond1.08790841
57MP0010234_abnormal_vibrissa_follicle1.06444841
58MP0000762_abnormal_tongue_morphology1.06197780
59MP0003656_abnormal_erythrocyte_physiolo1.05548134
60MP0003634_abnormal_glial_cell1.05186235
61MP0000778_abnormal_nervous_system1.03405601
62MP0003633_abnormal_nervous_system1.02239352
63MP0000598_abnormal_liver_morphology0.99759230
64MP0004858_abnormal_nervous_system0.98415279
65MP0002736_abnormal_nociception_after0.98154203
66MP0002876_abnormal_thyroid_physiology0.97565952
67MP0002090_abnormal_vision0.96649075
68MP0002272_abnormal_nervous_system0.96008603
69MP0003941_abnormal_skin_development0.95374181
70MP0000604_amyloidosis0.94699790
71MP0010386_abnormal_urinary_bladder0.93567809
72MP0009763_increased_sensitivity_to0.92748493
73MP0008569_lethality_at_weaning0.91235742
74MP0002572_abnormal_emotion/affect_behav0.90905818
75MP0003631_nervous_system_phenotype0.89879792
76MP0001968_abnormal_touch/_nociception0.89623802
77MP0009384_cardiac_valve_regurgitation0.88676376
78MP0003690_abnormal_glial_cell0.85958078
79MP0005670_abnormal_white_adipose0.85520589
80MP0000026_abnormal_inner_ear0.84969696
81MP0004142_abnormal_muscle_tone0.84582452
82MP0005408_hypopigmentation0.84461344
83MP0005636_abnormal_mineral_homeostasis0.83938763
84MP0005377_hearing/vestibular/ear_phenot0.82470959
85MP0003878_abnormal_ear_physiology0.82470959
86MP0000579_abnormal_nail_morphology0.81900735
87MP0001485_abnormal_pinna_reflex0.81068797
88MP0009642_abnormal_blood_homeostasis0.77873297
89MP0009765_abnormal_xenobiotic_induced0.77453274
90MP0002249_abnormal_larynx_morphology0.77246611
91MP0002734_abnormal_mechanical_nocicepti0.77209214
92MP0008469_abnormal_protein_level0.76692010
93MP0009053_abnormal_anal_canal0.76520476
94MP0002060_abnormal_skin_morphology0.76107841
95MP0001905_abnormal_dopamine_level0.75753917
96MP0001963_abnormal_hearing_physiology0.75752654
97MP0002909_abnormal_adrenal_gland0.75328861
98MP0005551_abnormal_eye_electrophysiolog0.75219485
99MP0010368_abnormal_lymphatic_system0.74690150
100MP0005501_abnormal_skin_physiology0.73437279
101MP0005187_abnormal_penis_morphology0.71950508
102MP0005376_homeostasis/metabolism_phenot0.70984935
103MP0002735_abnormal_chemical_nociception0.69131839
104MP0001177_atelectasis0.68141754
105MP0002971_abnormal_brown_adipose0.66444346
106MP0001270_distended_abdomen0.65076765
107MP0006036_abnormal_mitochondrial_physio0.64405194
108MP0003718_maternal_effect0.63838344
109MP0002078_abnormal_glucose_homeostasis0.63755759
110MP0003453_abnormal_keratinocyte_physiol0.63737894
111MP0004130_abnormal_muscle_cell0.62692584
112MP0001853_heart_inflammation0.61759586
113MP0005334_abnormal_fat_pad0.61027599
114MP0005220_abnormal_exocrine_pancreas0.59220475
115MP0001661_extended_life_span0.58789790
116MP0005535_abnormal_body_temperature0.58732900
117MP0003638_abnormal_response/metabolism_0.58439526
118MP0004782_abnormal_surfactant_physiolog0.57559655
119MP0003329_amyloid_beta_deposits0.57268593
120MP0005084_abnormal_gallbladder_morpholo0.57031526
121MP0005266_abnormal_metabolism0.54117245
122MP0001216_abnormal_epidermal_layer0.53874502
123MP0000647_abnormal_sebaceous_gland0.53353384
124MP0005395_other_phenotype0.53118299
125MP0009780_abnormal_chondrocyte_physiolo0.52610336
126MP0000639_abnormal_adrenal_gland0.51415688
127MP0001756_abnormal_urination0.51346212
128MP0000427_abnormal_hair_cycle0.48771639
129MP0002098_abnormal_vibrissa_morphology0.47925176
130MP0005448_abnormal_energy_balance0.45983240
131MP0000377_abnormal_hair_follicle0.45893374
132MP0001243_abnormal_dermal_layer0.45880780
133MP0006035_abnormal_mitochondrial_morpho0.44993659
134MP0000566_synostosis0.44186194
135MP0005275_abnormal_skin_tensile0.43831971
136MP0009379_abnormal_foot_pigmentation0.42222289
137MP0005248_abnormal_Harderian_gland0.42008647
138MP0008874_decreased_physiological_sensi0.41622376
139MP0002136_abnormal_kidney_physiology0.41083914
140MP0005464_abnormal_platelet_physiology0.40672766
141MP0010771_integument_phenotype0.40319223
142MP0003075_altered_response_to0.40107767
143MP0002928_abnormal_bile_duct0.39440018
144MP0004947_skin_inflammation0.38977344
145MP0000467_abnormal_esophagus_morphology0.38061608
146MP0003724_increased_susceptibility_to0.37688134
147MP0001881_abnormal_mammary_gland0.37230898
148MP0003436_decreased_susceptibility_to0.37160233
149MP0002822_catalepsy0.37051510
150MP0002132_abnormal_respiratory_system0.36000543
151MP0005646_abnormal_pituitary_gland0.34569002
152MP0003953_abnormal_hormone_level0.34253589

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.45423465
2Deep venous thrombosis (HP:0002625)7.35029538
3Abnormality of aromatic amino acid family metabolism (HP:0004338)7.18831946
4Prolonged partial thromboplastin time (HP:0003645)6.64832148
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.61838377
6Xanthomatosis (HP:0000991)6.59326892
7Hypobetalipoproteinemia (HP:0003563)6.41055118
8Hyperlipoproteinemia (HP:0010980)5.99704858
9Increased circulating renin level (HP:0000848)5.50056503
10Complement deficiency (HP:0004431)5.22662254
11Hypolipoproteinemia (HP:0010981)5.02905914
12Joint hemorrhage (HP:0005261)4.73565821
13Epidermoid cyst (HP:0200040)4.60475702
14Hypoalphalipoproteinemia (HP:0003233)4.59677773
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.58560478
16Hyperammonemia (HP:0001987)4.52193356
17Hyperglycinemia (HP:0002154)4.39312624
18Hypokalemic alkalosis (HP:0001949)4.36953580
19Metabolic alkalosis (HP:0200114)4.35139022
20Abnormality of the common coagulation pathway (HP:0010990)4.32346998
21Abnormality of methionine metabolism (HP:0010901)4.23350839
22Ketosis (HP:0001946)4.15798289
23Fat malabsorption (HP:0002630)4.15557625
24Abnormality of sulfur amino acid metabolism (HP:0004339)4.14508595
25Abnormality of glutamine family amino acid metabolism (HP:0010902)4.08514412
26Abnormality of aspartate family amino acid metabolism (HP:0010899)4.07729325
27Hyperglycinuria (HP:0003108)3.98439847
28Abnormality of glycine metabolism (HP:0010895)3.94343620
29Abnormality of serine family amino acid metabolism (HP:0010894)3.94343620
30Abnormality of complement system (HP:0005339)3.87218757
31Hypoglycemic coma (HP:0001325)3.77571188
32Abnormality of pyrimidine metabolism (HP:0004353)3.71579802
33Conjugated hyperbilirubinemia (HP:0002908)3.71485386
34Hypercholesterolemia (HP:0003124)3.66903228
35Abnormality of the intrinsic pathway (HP:0010989)3.60357570
36Hyperactive renin-angiotensin system (HP:0000841)3.32650696
37Abnormality of fatty-acid metabolism (HP:0004359)3.28285992
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.28219527
39Hypomagnesemia (HP:0002917)3.26606672
40Hyperbilirubinemia (HP:0002904)3.25562842
41Delayed CNS myelination (HP:0002188)3.15802998
42Steatorrhea (HP:0002570)3.14991652
43Hyperaldosteronism (HP:0000859)3.08158335
44Ketoacidosis (HP:0001993)2.99951107
45Action tremor (HP:0002345)2.98432039
46Abnormality of nail color (HP:0100643)2.97495803
47Renal salt wasting (HP:0000127)2.96093944
48Abnormality of nucleobase metabolism (HP:0010932)2.93744067
49Abnormality of serum amino acid levels (HP:0003112)2.91645982
50Myocardial infarction (HP:0001658)2.88566219
51Hepatocellular carcinoma (HP:0001402)2.88057067
52Alopecia of scalp (HP:0002293)2.80607972
53Spontaneous abortion (HP:0005268)2.77643611
54Hypochromic microcytic anemia (HP:0004840)2.76014201
55Metabolic acidosis (HP:0001942)2.70864317
56Split foot (HP:0001839)2.66916219
57Polyuria (HP:0000103)2.64516731
58Systemic lupus erythematosus (HP:0002725)2.63791035
59White forelock (HP:0002211)2.63613097
60Abnormal urine output (HP:0012590)2.62712951
61Skin nodule (HP:0200036)2.60087132
62Polyphagia (HP:0002591)2.59685886
63Vascular calcification (HP:0004934)2.59613407
64Hyperphosphaturia (HP:0003109)2.59450261
65Abnormality of magnesium homeostasis (HP:0004921)2.59013774
66Abnormality of purine metabolism (HP:0004352)2.54826200
67Dicarboxylic aciduria (HP:0003215)2.52412141
68Abnormality of dicarboxylic acid metabolism (HP:0010995)2.52412141
69Lethargy (HP:0001254)2.49099757
70Patchy hypopigmentation of hair (HP:0011365)2.47056797
71Acanthocytosis (HP:0001927)2.45944940
72Hypoglycemic seizures (HP:0002173)2.44460424
73Neurofibrillary tangles (HP:0002185)2.43119241
74Blue irides (HP:0000635)2.39621420
75Amyloidosis (HP:0011034)2.37000328
76Neonatal onset (HP:0003623)2.34769447
77Palmoplantar hyperkeratosis (HP:0000972)2.34730727
78Glomerulonephritis (HP:0000099)2.34571902
79Abnormality of renal excretion (HP:0011036)2.33838278
80Abnormal gallbladder morphology (HP:0012437)2.33436680
81Spastic diplegia (HP:0001264)2.33347391
82Abnormal eating behavior (HP:0100738)2.30457560
83Cerebral edema (HP:0002181)2.30141135
84Mitral stenosis (HP:0001718)2.29471935
85Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.28784874
86Cardiovascular calcification (HP:0011915)2.28492713
87Abnormal drinking behavior (HP:0030082)2.25808680
88Polydipsia (HP:0001959)2.25808680
89Cholelithiasis (HP:0001081)2.25697014
90Irritability (HP:0000737)2.25039662
91Malnutrition (HP:0004395)2.24955415
92Abnormality of renin-angiotensin system (HP:0000847)2.23586659
93Abnormal gallbladder physiology (HP:0012438)2.23483858
94Cholecystitis (HP:0001082)2.23483858
95Abnormality of secondary sexual hair (HP:0009888)2.21085182
96Abnormality of the axillary hair (HP:0100134)2.21085182
97Recurrent gram-negative bacterial infections (HP:0005420)2.20865841
98Hypokalemia (HP:0002900)2.20478508
99Aplasia involving bones of the extremities (HP:0009825)2.20304815
100Aplasia involving bones of the upper limbs (HP:0009823)2.20304815
101Aplasia of the phalanges of the hand (HP:0009802)2.20304815
102Gout (HP:0001997)2.20012530
103Bifid scrotum (HP:0000048)2.19264710
104Plantar hyperkeratosis (HP:0007556)2.17618507
105Palmar hyperkeratosis (HP:0010765)2.13343919
106Osteomalacia (HP:0002749)2.11389993
107Proximal tubulopathy (HP:0000114)2.11021603
108Myokymia (HP:0002411)2.10792702
109Menorrhagia (HP:0000132)2.09742212
110Pancreatitis (HP:0001733)2.09091631
111Intention tremor (HP:0002080)2.08764031
112Gingival bleeding (HP:0000225)2.08421765
113Abnormality of urine glucose concentration (HP:0011016)2.08049169
114Glycosuria (HP:0003076)2.08049169
115Atrioventricular block (HP:0001678)2.07626384
116Abnormality of chloride homeostasis (HP:0011422)2.06725536
117Brushfield spots (HP:0001088)2.06243700
118Esophageal varix (HP:0002040)2.05993827
119Megalencephaly (HP:0001355)2.05810665
120Rickets (HP:0002748)2.05285360
121Sensorimotor neuropathy (HP:0007141)2.03941734
122Late onset (HP:0003584)2.03612891
123Hypotrichosis (HP:0001006)2.02685065
124Enlarged kidneys (HP:0000105)2.01272267
125Abnormal urine phosphate concentration (HP:0012599)2.00578387
126Generalized aminoaciduria (HP:0002909)1.99776319
127Erythroderma (HP:0001019)1.98099882
128Hypophosphatemic rickets (HP:0004912)1.97932887
129Vomiting (HP:0002013)1.96944131
130Hemiparesis (HP:0001269)1.93365296
131Thrombophlebitis (HP:0004418)1.92777368
132Erythema (HP:0010783)1.91950079
133Opisthotonus (HP:0002179)1.89930757
134Abnormality of the gallbladder (HP:0005264)1.87431292
135Hydroxyprolinuria (HP:0003080)1.86617587
136Abnormality of proline metabolism (HP:0010907)1.86617587
137Renal cortical cysts (HP:0000803)1.86532550
138Poikilocytosis (HP:0004447)1.86367750
139Hyperinsulinemic hypoglycemia (HP:0000825)1.85744518
140Onycholysis (HP:0001806)1.82926695
141Hemorrhage of the eye (HP:0011885)1.81465449
142Abnormal cartilage morphology (HP:0002763)1.78077768
143Parakeratosis (HP:0001036)1.77242766
144Potter facies (HP:0002009)1.77196928
145Facial shape deformation (HP:0011334)1.77196928
146Paraparesis (HP:0002385)1.76586760
147Alkalosis (HP:0001948)1.76222092
148Abnormality of vitamin metabolism (HP:0100508)1.75677054
149Nephritis (HP:0000123)1.74546556
150Abnormal enzyme/coenzyme activity (HP:0012379)1.74265300
151Elevated hepatic transaminases (HP:0002910)1.73698433
152Spastic paraparesis (HP:0002313)1.71736061
153Hypertriglyceridemia (HP:0002155)1.70745822
154Hyperglycemia (HP:0003074)1.70345633
155Abnormality of iron homeostasis (HP:0011031)1.70314902
156Abnormality of transition element cation homeostasis (HP:0011030)1.67247899

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.44846897
2SIK14.67966490
3NTRK24.52964299
4FGFR44.37366871
5WNK34.23503080
6ERN14.07336034
7CASK3.57402318
8MST1R3.53715369
9NTRK32.99060763
10MARK12.90455589
11INSRR2.81463449
12ERBB42.75777580
13OXSR12.69444347
14TAOK32.43431701
15NTRK12.23373982
16MAP2K42.18160763
17SGK2232.06526170
18SGK4942.06526170
19PIK3CG1.99236608
20FGFR21.96367898
21MAPK151.82560996
22TYK21.81377418
23BCR1.73029811
24MAPK111.72845463
25MAP3K31.70658561
26LATS11.68543347
27MAPK121.58819085
28PKN21.57906685
29TNIK1.55840033
30PTK61.52924580
31FRK1.45800062
32STK241.43657991
33FLT31.41696189
34ROCK21.41073768
35PNCK1.36159240
36MAPK71.33598063
37ABL21.32825706
38MAP3K41.31221784
39PAK61.31000095
40TRIB31.29357285
41CDK61.29231684
42MAP3K121.25578007
43MAP3K141.25396939
44MET1.24369905
45STK391.24025211
46GRK11.22830548
47DAPK21.22326085
48JAK21.21937485
49ARAF1.19783865
50MAP3K21.17198343
51MAPK41.13925989
52PRKAA21.12604990
53BMPR1B1.12136825
54NEK91.10530076
55ERBB31.09510643
56CSNK1G21.05323813
57MAP3K71.03791470
58IRAK31.01137049
59PHKG20.99390002
60PHKG10.99390002
61CAMK2B0.99237173
62WNK40.99036802
63PINK10.98648472
64ERBB20.97633335
65PRKD30.97178099
66LMTK20.94333987
67UHMK10.94317058
68JAK10.94051322
69KDR0.92639991
70MINK10.90847810
71TBK10.89976696
72CDK50.85701731
73PRKCZ0.82994077
74KSR20.82662731
75SGK10.82485406
76MOS0.81780375
77MAP4K20.81620619
78MAP2K70.80807655
79DYRK1B0.80648146
80CAMK2D0.80023481
81MAP2K30.77826460
82CAMK2A0.76920897
83EPHA30.76617881
84FER0.76253823
85MAP2K60.76102654
86BMPR20.75827590
87ROCK10.75027579
88MAPKAPK30.74394950
89PRKACG0.73978602
90FGFR30.73433716
91MAPK130.73423807
92PRKCG0.73408064
93GRK60.72524465
94PIM20.71555884
95FGFR10.70576255
96TGFBR20.70561048
97STK38L0.69183769
98GSK3A0.69159702
99PRKCE0.68390494
100MAP3K100.67339097
101TIE10.64676657
102CAMK2G0.64667477
103PIK3CA0.64581522
104TYRO30.62540492
105IGF1R0.60523512
106MAP3K110.59283895
107CSNK1A10.58563332
108PTK20.57101235
109EPHB10.56874516
110IKBKE0.56375215
111CSK0.56305035
112PRKAA10.55805018
113CAMK1D0.55682502
114EPHA40.55112598
115CSNK1A1L0.54558551
116MAPK100.53342595
117CSNK1G30.52139221
118EPHB20.51366983
119PRKCQ0.51062906
120MAP2K10.51043499
121PLK20.50784156
122WEE10.45536258
123PKN10.45436443
124SRC0.44742373
125PDPK10.42194307
126MAP3K10.42170775
127PDGFRB0.41750821
128CDK40.40579272
129RPS6KA30.38804801
130PBK0.37918160
131DYRK1A0.37357440
132CAMKK10.37261068
133PRKG10.37246427
134SGK30.37104221
135PRKCA0.36732820
136MAP3K50.36564629
137RIPK10.36476119
138NEK60.35105193
139EPHA20.33823603
140CSF1R0.33822119
141TAOK20.33102607
142IRAK20.31864647
143PAK30.31064369
144EGFR0.30129042
145MAP2K20.29892741
146MAP3K60.28970548
147SGK20.28809750
148RET0.28136471
149MAPK30.27795440
150CSNK1G10.27229250
151ABL10.26970036
152IRAK10.26750579
153ITK0.26626748
154LRRK20.26402733
155PDK10.24172273
156LATS20.24112520
157PRKACA0.22259224
158BMX0.20292782

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.56319715
2Nitrogen metabolism_Homo sapiens_hsa009103.48829548
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.33969712
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.20432621
5Arginine biosynthesis_Homo sapiens_hsa002202.99538484
6Complement and coagulation cascades_Homo sapiens_hsa046102.75384538
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.68466944
8Tryptophan metabolism_Homo sapiens_hsa003802.65959554
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.52349813
10Fatty acid degradation_Homo sapiens_hsa000712.50958709
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.45362693
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.34605553
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.27554561
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.23333464
15Butanoate metabolism_Homo sapiens_hsa006502.11936993
16Peroxisome_Homo sapiens_hsa041462.08128739
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.06914910
18Chemical carcinogenesis_Homo sapiens_hsa052042.06637739
19Histidine metabolism_Homo sapiens_hsa003402.01996485
20Steroid hormone biosynthesis_Homo sapiens_hsa001402.00215302
21Propanoate metabolism_Homo sapiens_hsa006401.90908398
22Retinol metabolism_Homo sapiens_hsa008301.89184470
23PPAR signaling pathway_Homo sapiens_hsa033201.88633931
24Caffeine metabolism_Homo sapiens_hsa002321.83532235
25Fatty acid metabolism_Homo sapiens_hsa012121.80094688
26beta-Alanine metabolism_Homo sapiens_hsa004101.75295911
27Staphylococcus aureus infection_Homo sapiens_hsa051501.74578371
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.72483428
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.71666158
30Phenylalanine metabolism_Homo sapiens_hsa003601.65160938
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64668734
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58461647
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56499954
34Tyrosine metabolism_Homo sapiens_hsa003501.52398312
35Bile secretion_Homo sapiens_hsa049761.51507781
36Fatty acid elongation_Homo sapiens_hsa000621.47303281
37Selenocompound metabolism_Homo sapiens_hsa004501.40992621
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.34640155
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.33658070
40Sulfur metabolism_Homo sapiens_hsa009201.31558874
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30587956
42Pyruvate metabolism_Homo sapiens_hsa006201.28250650
43Starch and sucrose metabolism_Homo sapiens_hsa005001.24792126
44ABC transporters_Homo sapiens_hsa020101.22652303
45Steroid biosynthesis_Homo sapiens_hsa001001.22128214
46Fat digestion and absorption_Homo sapiens_hsa049751.19582005
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.17099920
48Folate biosynthesis_Homo sapiens_hsa007901.13483778
49Biosynthesis of amino acids_Homo sapiens_hsa012301.08022382
50Carbon metabolism_Homo sapiens_hsa012001.02880662
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.95728523
52Vitamin digestion and absorption_Homo sapiens_hsa049770.94593292
53Arginine and proline metabolism_Homo sapiens_hsa003300.93807233
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92874703
55Sulfur relay system_Homo sapiens_hsa041220.91433445
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88989426
57Vitamin B6 metabolism_Homo sapiens_hsa007500.85262236
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81890021
59Glutathione metabolism_Homo sapiens_hsa004800.69756528
60Glycerolipid metabolism_Homo sapiens_hsa005610.68088699
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67197576
62* Lysine degradation_Homo sapiens_hsa003100.66803116
63GABAergic synapse_Homo sapiens_hsa047270.61973726
64One carbon pool by folate_Homo sapiens_hsa006700.61441425
65Fatty acid biosynthesis_Homo sapiens_hsa000610.61126244
66Nicotine addiction_Homo sapiens_hsa050330.51201716
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50858215
68Glutamatergic synapse_Homo sapiens_hsa047240.50488735
69Pentose phosphate pathway_Homo sapiens_hsa000300.48299964
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46764018
71Metabolic pathways_Homo sapiens_hsa011000.46686332
72Gastric acid secretion_Homo sapiens_hsa049710.43037069
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42490682
74Linoleic acid metabolism_Homo sapiens_hsa005910.41089492
75Serotonergic synapse_Homo sapiens_hsa047260.39815960
76Circadian entrainment_Homo sapiens_hsa047130.39630785
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37565419
78Prion diseases_Homo sapiens_hsa050200.31242301
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.29976405
80Amphetamine addiction_Homo sapiens_hsa050310.28762717
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.27591114
82Cocaine addiction_Homo sapiens_hsa050300.24058892
83Insulin secretion_Homo sapiens_hsa049110.22993526
84Insulin resistance_Homo sapiens_hsa049310.21665004
85Dopaminergic synapse_Homo sapiens_hsa047280.21653809
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.21595632
87Galactose metabolism_Homo sapiens_hsa000520.20269487
88Collecting duct acid secretion_Homo sapiens_hsa049660.19895895
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.19841931
90Morphine addiction_Homo sapiens_hsa050320.19319941
91Fructose and mannose metabolism_Homo sapiens_hsa000510.16447549
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15089510
93Renin secretion_Homo sapiens_hsa049240.14419998
94Synaptic vesicle cycle_Homo sapiens_hsa047210.13210642
95Dorso-ventral axis formation_Homo sapiens_hsa043200.08206571
96Salivary secretion_Homo sapiens_hsa049700.07698717
97Glucagon signaling pathway_Homo sapiens_hsa049220.06721093
98Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.06139481
99Long-term depression_Homo sapiens_hsa047300.02878999
100cAMP signaling pathway_Homo sapiens_hsa040240.01846466
101Pancreatic secretion_Homo sapiens_hsa049720.01826667
102Arachidonic acid metabolism_Homo sapiens_hsa005900.01204865
103Long-term potentiation_Homo sapiens_hsa047200.00928673
104Ovarian steroidogenesis_Homo sapiens_hsa049130.00223766
105Bladder cancer_Homo sapiens_hsa05219-0.2437841
106Circadian rhythm_Homo sapiens_hsa04710-0.2264471
107Regulation of autophagy_Homo sapiens_hsa04140-0.2024635
108Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2020548
109Mineral absorption_Homo sapiens_hsa04978-0.1962911
110Amoebiasis_Homo sapiens_hsa05146-0.1939884
111Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1938417
112Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1933162
113Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1930848
114Renin-angiotensin system_Homo sapiens_hsa04614-0.1871247
115Sphingolipid metabolism_Homo sapiens_hsa00600-0.1771458
116Hepatitis C_Homo sapiens_hsa05160-0.1745079
117Insulin signaling pathway_Homo sapiens_hsa04910-0.1525466
118Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1275495
119African trypanosomiasis_Homo sapiens_hsa05143-0.1241613
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1226299
121Ether lipid metabolism_Homo sapiens_hsa00565-0.1123304
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0903129
123Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0494973
124AMPK signaling pathway_Homo sapiens_hsa04152-0.0107241

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