BBS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by severe pigmentary retinopathy, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene forms a multiprotein BBSome complex with seven other BBS proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1postsynaptic membrane organization (GO:0001941)5.05667567
2presynaptic membrane assembly (GO:0097105)4.75800769
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.67069165
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.49246388
5presynaptic membrane organization (GO:0097090)4.35186225
6regulation of rhodopsin mediated signaling pathway (GO:0022400)4.25131208
7synaptic vesicle maturation (GO:0016188)4.19497405
8rhodopsin mediated signaling pathway (GO:0016056)4.18700468
9response to pheromone (GO:0019236)4.10644122
10neuronal action potential propagation (GO:0019227)4.06520525
11C4-dicarboxylate transport (GO:0015740)4.02612636
12central nervous system myelination (GO:0022010)3.81725062
13axon ensheathment in central nervous system (GO:0032291)3.81725062
14growth hormone secretion (GO:0030252)3.67702687
15negative regulation of cytosolic calcium ion concentration (GO:0051481)3.64071926
16regulation of synaptic vesicle exocytosis (GO:2000300)3.59408849
17intraciliary transport (GO:0042073)3.58018581
18auditory behavior (GO:0031223)3.57418351
19retinal rod cell development (GO:0046548)3.55203782
20response to auditory stimulus (GO:0010996)3.54699936
21retinal cone cell development (GO:0046549)3.54610152
22epithelial cilium movement (GO:0003351)3.51133107
23cilium movement (GO:0003341)3.50281217
24photoreceptor cell development (GO:0042461)3.50025722
25regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.50003063
26* photoreceptor cell maintenance (GO:0045494)3.48128413
27positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.36934383
28regulation of synaptic vesicle transport (GO:1902803)3.34733276
29neurotransmitter uptake (GO:0001504)3.34548216
30pyrimidine nucleobase catabolic process (GO:0006208)3.33635093
31synaptic vesicle exocytosis (GO:0016079)3.33430586
32regulation of respiratory system process (GO:0044065)3.30711288
33glutamate secretion (GO:0014047)3.23590096
34membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.22583262
35eye photoreceptor cell development (GO:0042462)3.21882132
36ionotropic glutamate receptor signaling pathway (GO:0035235)3.21339597
37locomotory exploration behavior (GO:0035641)3.20708161
38regulation of cell communication by electrical coupling (GO:0010649)3.20705717
39membrane repolarization (GO:0086009)3.18795956
40negative regulation of neurotransmitter transport (GO:0051589)3.16473360
41glial cell proliferation (GO:0014009)3.14658076
42positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.14651229
43cellular potassium ion homeostasis (GO:0030007)3.14578703
44gamma-aminobutyric acid transport (GO:0015812)3.12179379
45regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.10207377
46regulation of synapse structural plasticity (GO:0051823)3.10049805
47negative regulation of synaptic transmission, GABAergic (GO:0032229)3.08901032
48membrane repolarization during action potential (GO:0086011)3.08812427
49cell communication by electrical coupling (GO:0010644)3.08738133
50cilium or flagellum-dependent cell motility (GO:0001539)3.07689552
51regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.06309940
52* nonmotile primary cilium assembly (GO:0035058)3.03852509
53neurotransmitter-gated ion channel clustering (GO:0072578)3.03091448
54synaptic vesicle docking involved in exocytosis (GO:0016081)3.02264420
55regulation of membrane repolarization (GO:0060306)3.02110948
56piRNA metabolic process (GO:0034587)3.01377850
57regulation of relaxation of muscle (GO:1901077)3.00401977
58innervation (GO:0060384)3.00332518
59response to gravity (GO:0009629)2.99113132
60eye photoreceptor cell differentiation (GO:0001754)2.96678487
61photoreceptor cell differentiation (GO:0046530)2.96678487
62fatty acid elongation (GO:0030497)2.94421510
63neurotransmitter secretion (GO:0007269)2.94360943
64regulation of voltage-gated calcium channel activity (GO:1901385)2.93155841
65regulation of neurotransmitter uptake (GO:0051580)2.92302141
66negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.90897672
67vocalization behavior (GO:0071625)2.89451391
68membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.89276594
69neuron recognition (GO:0008038)2.89095503
70GMP metabolic process (GO:0046037)2.89075093
71cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.88853535
72atrial cardiac muscle cell action potential (GO:0086014)2.88057404
73positive regulation of potassium ion transmembrane transport (GO:1901381)2.87467411
74axonemal dynein complex assembly (GO:0070286)2.86801189
75astrocyte differentiation (GO:0048708)2.86339613
76synapse assembly (GO:0007416)2.84359915
77regulation of cardiac muscle cell contraction (GO:0086004)2.82586095
78protein-chromophore linkage (GO:0018298)2.82026801
79startle response (GO:0001964)2.80701784
80potassium ion homeostasis (GO:0055075)2.80067621
81phosphorelay signal transduction system (GO:0000160)2.79547086
82* axoneme assembly (GO:0035082)2.79198973
83activation of protein kinase A activity (GO:0034199)2.78570839
84male meiosis (GO:0007140)2.78283595
85neuronal ion channel clustering (GO:0045161)2.77852841
86detection of light stimulus involved in visual perception (GO:0050908)2.77445032
87detection of light stimulus involved in sensory perception (GO:0050962)2.77445032
88nucleobase catabolic process (GO:0046113)2.76051775
89regulation of calcium ion-dependent exocytosis (GO:0017158)2.75990905
90L-amino acid import (GO:0043092)2.75647573
91synapsis (GO:0007129)2.74945381
92mechanosensory behavior (GO:0007638)2.74592390
93glutamate receptor signaling pathway (GO:0007215)2.74152525
94membrane depolarization during action potential (GO:0086010)2.74019122
95regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.73230133
96positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.72582978
97positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.72510116
98regulation of respiratory gaseous exchange (GO:0043576)2.72500285
99acidic amino acid transport (GO:0015800)2.72199504
100glycosphingolipid biosynthetic process (GO:0006688)2.71011641
101protein localization to cilium (GO:0061512)2.70406049
102sodium ion export (GO:0071436)2.70354137
103establishment of mitochondrion localization (GO:0051654)2.68763187
104* regulation of cilium movement (GO:0003352)2.68662416
105* cilium morphogenesis (GO:0060271)2.67102692
106negative regulation of hormone metabolic process (GO:0032351)2.66199868
107negative regulation of hormone biosynthetic process (GO:0032353)2.66199868
108neuron-neuron synaptic transmission (GO:0007270)2.65451930
109regulation of neuronal synaptic plasticity (GO:0048168)2.65250809
110chemosensory behavior (GO:0007635)2.63776794
111* cilium organization (GO:0044782)2.62559115
112regulation of beta-amyloid formation (GO:1902003)2.61822481
113ovulation cycle (GO:0042698)2.60597868
114* cilium assembly (GO:0042384)2.60216682
115layer formation in cerebral cortex (GO:0021819)2.59892917
116sensory perception of smell (GO:0007608)2.59724942
117motile cilium assembly (GO:0044458)2.58973030
118ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.58619281
119cerebellar Purkinje cell differentiation (GO:0021702)2.58399317
120calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.58051148
121* regulation of microtubule-based movement (GO:0060632)2.56631706
122transmission of nerve impulse (GO:0019226)2.56422589
123regulation of glutamate receptor signaling pathway (GO:1900449)2.55892643
124phototransduction (GO:0007602)2.53971838
125L-glutamate transport (GO:0015813)2.51469915
126cellular sodium ion homeostasis (GO:0006883)2.51350726
127establishment of nucleus localization (GO:0040023)2.50913099
128regulation of synaptic transmission, glutamatergic (GO:0051966)2.50909402
129neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.50868646
130positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.50809692
131positive regulation of synaptic transmission, GABAergic (GO:0032230)2.50762751
132protein polyglutamylation (GO:0018095)2.50410563
133neurotransmitter transport (GO:0006836)2.50072272
134positive regulation of mitochondrial fission (GO:0090141)2.49751068
135DNA methylation involved in gamete generation (GO:0043046)2.49458649
136detection of calcium ion (GO:0005513)2.49423471
137synaptic transmission, glutamatergic (GO:0035249)2.49315474
138regulation of vesicle fusion (GO:0031338)2.47783222
139positive regulation of potassium ion transport (GO:0043268)2.47312499
140regulation of neurotransmitter secretion (GO:0046928)2.45133801
141amino acid import (GO:0043090)2.44021299
142regulation of timing of cell differentiation (GO:0048505)2.43831713
143detection of light stimulus (GO:0009583)2.42811475
144regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.42078567
145potassium ion export (GO:0071435)2.41653349
146regulation of potassium ion transmembrane transport (GO:1901379)2.41626181
147protein localization to synapse (GO:0035418)2.41514096
148negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.41186009
149positive regulation of neurotransmitter transport (GO:0051590)2.40990486
150regulation of clathrin-mediated endocytosis (GO:2000369)2.40784160
151neuron cell-cell adhesion (GO:0007158)2.39945324
152phototransduction, visible light (GO:0007603)2.39929416
153axonal fasciculation (GO:0007413)2.39141288
154histone H3-K9 demethylation (GO:0033169)2.38898666
155long-term memory (GO:0007616)2.38871732
156epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.38326276
157lactate metabolic process (GO:0006089)2.37087884
158regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.35905992
159detection of visible light (GO:0009584)2.35631898
160calcium ion import (GO:0070509)2.35404885
161positive regulation of membrane potential (GO:0045838)2.34357397
162potassium ion import (GO:0010107)2.32286148
163regulation of development, heterochronic (GO:0040034)2.32210681

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.94490423
2GBX2_23144817_ChIP-Seq_PC3_Human2.97748546
3REST_21632747_ChIP-Seq_MESCs_Mouse2.59229470
4IGF1R_20145208_ChIP-Seq_DFB_Human2.56450391
5RARB_27405468_Chip-Seq_BRAIN_Mouse2.47686038
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.42928434
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.27666978
8REST_18959480_ChIP-ChIP_MESCs_Mouse2.27093424
9CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.25600749
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.23584794
11TAF15_26573619_Chip-Seq_HEK293_Human2.17868872
12DROSHA_22980978_ChIP-Seq_HELA_Human2.14056337
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.09966159
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.03926534
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02029464
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94333981
17VDR_22108803_ChIP-Seq_LS180_Human1.93563864
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.91860996
19CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.86628478
20RNF2_27304074_Chip-Seq_ESCs_Mouse1.80660178
21ZNF274_21170338_ChIP-Seq_K562_Hela1.79290630
22FUS_26573619_Chip-Seq_HEK293_Human1.78760981
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.76564677
24BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.72127552
25EZH2_27304074_Chip-Seq_ESCs_Mouse1.71685982
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.69979754
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.69484199
28RNF2_18974828_ChIP-Seq_MESCs_Mouse1.69484199
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.68210148
30MTF2_20144788_ChIP-Seq_MESCs_Mouse1.66841237
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.66563936
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61434639
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.58538374
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.58428278
35JARID2_20075857_ChIP-Seq_MESCs_Mouse1.58344565
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.56670389
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54001220
38SMAD3_21741376_ChIP-Seq_EPCs_Human1.53170943
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.51341390
40RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.51123443
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.50427543
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49239860
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48822073
44ER_23166858_ChIP-Seq_MCF-7_Human1.48409267
45RNF2_27304074_Chip-Seq_NSC_Mouse1.48242519
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.47814055
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47549149
48AR_25329375_ChIP-Seq_VCAP_Human1.46397382
49EED_16625203_ChIP-ChIP_MESCs_Mouse1.45031078
50SMAD4_21799915_ChIP-Seq_A2780_Human1.40987227
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40701942
52SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.38912139
53* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.34815740
54E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.34558821
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33559583
56TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31290521
57* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.31224505
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.28604149
59* STAT3_23295773_ChIP-Seq_U87_Human1.28101305
60* AR_19668381_ChIP-Seq_PC3_Human1.26459440
61BCAT_22108803_ChIP-Seq_LS180_Human1.26049135
62RUNX2_22187159_ChIP-Seq_PCA_Human1.24290283
63CBP_20019798_ChIP-Seq_JUKART_Human1.21983884
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21983884
65EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20931517
66ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.20657296
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20445955
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20153167
69* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19457042
70TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19405210
71RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.19233491
72DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19011579
73CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18798253
74TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18024521
75EWS_26573619_Chip-Seq_HEK293_Human1.17067177
76YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16636855
77SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16050705
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.15716173
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15443962
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15071638
81SALL1_21062744_ChIP-ChIP_HESCs_Human1.15003528
82TCF4_22108803_ChIP-Seq_LS180_Human1.14806174
83BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12443151
84GATA1_26923725_Chip-Seq_HPCs_Mouse1.11685261
85POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11376155
86RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.11251396
87SOX2_21211035_ChIP-Seq_LN229_Gbm1.11246969
88* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.11138329
89SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11111920
90* TCF4_23295773_ChIP-Seq_U87_Human1.10982325
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09840649
92CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09358000
93P53_22387025_ChIP-Seq_ESCs_Mouse1.08714103
94WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08065526
95ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07986318
96WDR5_24793694_ChIP-Seq_LNCAP_Human1.07381210
97SMAD4_21741376_ChIP-Seq_EPCs_Human1.07355875
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06237656
99MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05291431
100TAL1_26923725_Chip-Seq_HPCs_Mouse1.03812895
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.03808354
102TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03372519
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03372519
104FLI1_21867929_ChIP-Seq_TH2_Mouse1.03233559
105MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01824205
106KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01715477
107RING1B_27294783_Chip-Seq_ESCs_Mouse1.01577683
108KDM2B_26808549_Chip-Seq_REH_Human1.00551941
109* TET1_21490601_ChIP-Seq_MESCs_Mouse0.99989571
110TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99985350
111CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99404594
112ELK4_26923725_Chip-Seq_MESODERM_Mouse0.99142208
113P300_19829295_ChIP-Seq_ESCs_Human0.99057786
114AR_21572438_ChIP-Seq_LNCaP_Human0.98643691
115* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98396459
116PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98302124
117ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98174565
118MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97838690
119RING1B_27294783_Chip-Seq_NPCs_Mouse0.97229067
120SOX9_26525672_Chip-Seq_HEART_Mouse0.97215552
121TBX3_20139965_ChIP-Seq_ESCs_Mouse0.97073956
122FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97018752
123SMAD3_21741376_ChIP-Seq_ESCs_Human0.96056989
124TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95505533
125STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95405909
126SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95009232
127E2F1_18555785_Chip-Seq_ESCs_Mouse0.95001579
128KDM2B_26808549_Chip-Seq_K562_Human0.94806898
129PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92822323
130HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.90595690
131* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90108428
132TBL1_22424771_ChIP-Seq_293T_Human0.89415146
133NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.89300699
134PIAS1_25552417_ChIP-Seq_VCAP_Human0.88336677
135TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86808391
136SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.84648800
137STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84581873
138LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84458967
139ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84415073
140WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.84264968

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006072_abnormal_retinal_apoptosis3.73192489
2* MP0005551_abnormal_eye_electrophysiolog3.31428362
3MP0004859_abnormal_synaptic_plasticity3.11189192
4MP0005253_abnormal_eye_physiology2.83341055
5MP0002638_abnormal_pupillary_reflex2.77900492
6* MP0001984_abnormal_olfaction2.77116826
7MP0002653_abnormal_ependyma_morphology2.50224090
8MP0002909_abnormal_adrenal_gland2.46711114
9MP0003635_abnormal_synaptic_transmissio2.45257386
10MP0004270_analgesia2.39791178
11MP0003880_abnormal_central_pattern2.32044350
12MP0003122_maternal_imprinting2.14485593
13MP0003136_yellow_coat_color2.14152381
14MP0001502_abnormal_circadian_rhythm2.11878770
15MP0005646_abnormal_pituitary_gland2.11568600
16MP0005423_abnormal_somatic_nervous2.11188342
17MP0009046_muscle_twitch1.95393375
18MP0005645_abnormal_hypothalamus_physiol1.93700747
19MP0002063_abnormal_learning/memory/cond1.91548526
20MP0006292_abnormal_olfactory_placode1.89578747
21MP0002064_seizures1.85998874
22MP0003011_delayed_dark_adaptation1.84334030
23MP0003283_abnormal_digestive_organ1.83685520
24MP0000013_abnormal_adipose_tissue1.72441530
25* MP0001486_abnormal_startle_reflex1.71242508
26MP0004885_abnormal_endolymph1.70855369
27MP0009745_abnormal_behavioral_response1.68226572
28MP0002272_abnormal_nervous_system1.67658680
29MP0005394_taste/olfaction_phenotype1.66998964
30MP0005499_abnormal_olfactory_system1.66998964
31MP0009780_abnormal_chondrocyte_physiolo1.54843650
32MP0008789_abnormal_olfactory_epithelium1.54475310
33MP0004043_abnormal_pH_regulation1.53106891
34MP0001905_abnormal_dopamine_level1.52888818
35* MP0002572_abnormal_emotion/affect_behav1.52046122
36MP0000383_abnormal_hair_follicle1.51358932
37MP0001986_abnormal_taste_sensitivity1.47718147
38MP0002735_abnormal_chemical_nociception1.47714107
39* MP0002882_abnormal_neuron_morphology1.47569557
40MP0003121_genomic_imprinting1.47366648
41MP0002229_neurodegeneration1.45033759
42MP0004133_heterotaxia1.44862968
43MP0000631_abnormal_neuroendocrine_gland1.40881262
44* MP0002734_abnormal_mechanical_nocicepti1.40265518
45MP0002557_abnormal_social/conspecific_i1.39184949
46MP0001968_abnormal_touch/_nociception1.37339984
47MP0002822_catalepsy1.35848550
48MP0000569_abnormal_digit_pigmentation1.35381608
49MP0003690_abnormal_glial_cell1.34743774
50MP0002067_abnormal_sensory_capabilities1.34338615
51MP0002184_abnormal_innervation1.32581428
52* MP0005195_abnormal_posterior_eye1.31520749
53MP0005410_abnormal_fertilization1.30534147
54MP0004811_abnormal_neuron_physiology1.28386722
55MP0005391_vision/eye_phenotype1.28076842
56MP0004215_abnormal_myocardial_fiber1.27869028
57MP0004142_abnormal_muscle_tone1.26663727
58MP0002733_abnormal_thermal_nociception1.26626202
59MP0000566_synostosis1.25743944
60MP0000778_abnormal_nervous_system1.25361608
61* MP0002752_abnormal_somatic_nervous1.25148767
62MP0003787_abnormal_imprinting1.24039981
63MP0010386_abnormal_urinary_bladder1.23021327
64MP0008961_abnormal_basal_metabolism1.20945489
65MP0008877_abnormal_DNA_methylation1.20471549
66MP0004145_abnormal_muscle_electrophysio1.18039803
67MP0008569_lethality_at_weaning1.16545594
68MP0003631_nervous_system_phenotype1.16391087
69MP0001944_abnormal_pancreas_morphology1.13557687
70MP0000955_abnormal_spinal_cord1.11610962
71MP0000427_abnormal_hair_cycle1.10615664
72MP0004742_abnormal_vestibular_system1.09535924
73MP0001299_abnormal_eye_distance/1.09404975
74* MP0001970_abnormal_pain_threshold1.06699665
75MP0001440_abnormal_grooming_behavior1.06393574
76MP0002837_dystrophic_cardiac_calcinosis1.06172614
77MP0003632_abnormal_nervous_system1.05840593
78MP0002090_abnormal_vision1.04690190
79MP0004233_abnormal_muscle_weight1.02265006
80MP0004924_abnormal_behavior1.01390009
81MP0005386_behavior/neurological_phenoty1.01390009
82* MP0002152_abnormal_brain_morphology1.00948370
83MP0001501_abnormal_sleep_pattern1.00861990
84MP0003329_amyloid_beta_deposits1.00289346
85MP0003634_abnormal_glial_cell1.00252799
86* MP0003698_abnormal_male_reproductive0.99565742
87MP0002693_abnormal_pancreas_physiology0.97329740
88MP0005167_abnormal_blood-brain_barrier0.96712487
89MP0003890_abnormal_embryonic-extraembry0.95295822
90MP0000026_abnormal_inner_ear0.94490319
91MP0005248_abnormal_Harderian_gland0.94224268
92MP0003119_abnormal_digestive_system0.93475444
93MP0002736_abnormal_nociception_after0.93430206
94MP0001324_abnormal_eye_pigmentation0.93420253
95MP0004858_abnormal_nervous_system0.92576888
96MP0001348_abnormal_lacrimal_gland0.91634743
97* MP0002066_abnormal_motor_capabilities/c0.91625976
98MP0002234_abnormal_pharynx_morphology0.91264310
99MP0002877_abnormal_melanocyte_morpholog0.90360124
100MP0000537_abnormal_urethra_morphology0.90202565
101MP0000920_abnormal_myelination0.88188472
102MP0003879_abnormal_hair_cell0.86377659
103MP0002102_abnormal_ear_morphology0.85612126
104MP0000647_abnormal_sebaceous_gland0.84302131
105MP0001177_atelectasis0.83660334
106MP0001529_abnormal_vocalization0.83211974
107MP0006276_abnormal_autonomic_nervous0.82969264
108MP0003861_abnormal_nervous_system0.81960771
109MP0000428_abnormal_craniofacial_morphol0.81248485
110MP0005187_abnormal_penis_morphology0.81099274
111MP0010678_abnormal_skin_adnexa0.78952510
112MP0001485_abnormal_pinna_reflex0.78085535
113MP0003633_abnormal_nervous_system0.77886047
114MP0000003_abnormal_adipose_tissue0.76957745
115* MP0002069_abnormal_eating/drinking_beha0.76189428
116MP0002127_abnormal_cardiovascular_syste0.75365291
117MP0004147_increased_porphyrin_level0.74760855
118MP0000639_abnormal_adrenal_gland0.74593895
119MP0002928_abnormal_bile_duct0.73954764
120MP0001963_abnormal_hearing_physiology0.73828857
121MP0010030_abnormal_orbit_morphology0.73430751
122MP0003123_paternal_imprinting0.70842701
123MP0000751_myopathy0.70239282
124MP0003137_abnormal_impulse_conducting0.69270091
125MP0001270_distended_abdomen0.66290367

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)5.10138966
2Central scotoma (HP:0000603)4.80512661
3Bony spicule pigmentary retinopathy (HP:0007737)4.79219055
4Scotoma (HP:0000575)4.20250958
5Abnormality of macular pigmentation (HP:0008002)3.89277730
6Action tremor (HP:0002345)3.77918346
7Abnormal rod and cone electroretinograms (HP:0008323)3.73111630
8Focal motor seizures (HP:0011153)3.59232245
9* Medial flaring of the eyebrow (HP:0010747)3.33082468
10Absent/shortened dynein arms (HP:0200106)3.24416020
11Dynein arm defect of respiratory motile cilia (HP:0012255)3.24416020
12Absent rod-and cone-mediated responses on ERG (HP:0007688)3.23245611
13Type II diabetes mellitus (HP:0005978)3.17071831
14Hemiplegia (HP:0002301)3.16300733
15* Gait imbalance (HP:0002141)3.06469796
16Occipital encephalocele (HP:0002085)2.97527378
17Amyotrophic lateral sclerosis (HP:0007354)2.90169046
18* Congenital primary aphakia (HP:0007707)2.89347825
19Abnormal ciliary motility (HP:0012262)2.86550024
20Dyschromatopsia (HP:0007641)2.83657196
21Abnormality of the corticospinal tract (HP:0002492)2.82235903
22Absent speech (HP:0001344)2.78434618
23Myokymia (HP:0002411)2.78421529
24Pancreatic fibrosis (HP:0100732)2.77591433
25Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.76092936
26Degeneration of the lateral corticospinal tracts (HP:0002314)2.76092936
27True hermaphroditism (HP:0010459)2.74542932
28Abnormal respiratory motile cilium physiology (HP:0012261)2.72071289
29Hyperventilation (HP:0002883)2.70470773
30* Nephrogenic diabetes insipidus (HP:0009806)2.69254954
31Abnormal respiratory motile cilium morphology (HP:0005938)2.68297822
32Abnormal respiratory epithelium morphology (HP:0012253)2.68297822
33Type II lissencephaly (HP:0007260)2.64851542
34Chorioretinal atrophy (HP:0000533)2.58642735
35Focal seizures (HP:0007359)2.58404849
36Visual hallucinations (HP:0002367)2.56702259
37Ulnar claw (HP:0001178)2.55986514
38* Retinitis pigmentosa (HP:0000510)2.53245820
39Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.49912205
40Drooling (HP:0002307)2.48227319
41Attenuation of retinal blood vessels (HP:0007843)2.47279039
42Abnormality of midbrain morphology (HP:0002418)2.47074766
43Molar tooth sign on MRI (HP:0002419)2.47074766
44Supranuclear gaze palsy (HP:0000605)2.44760105
45Megalencephaly (HP:0001355)2.42343132
46Bifid tongue (HP:0010297)2.39251618
47Decreased central vision (HP:0007663)2.39112523
48Generalized tonic-clonic seizures (HP:0002069)2.35205153
49Abnormality of the lower motor neuron (HP:0002366)2.34712239
50Epileptic encephalopathy (HP:0200134)2.34248403
51Abolished electroretinogram (ERG) (HP:0000550)2.34021986
52Ankle clonus (HP:0011448)2.32770444
53Volvulus (HP:0002580)2.26871685
54Retinal dysplasia (HP:0007973)2.25210409
55Excessive salivation (HP:0003781)2.24092672
56Oligodactyly (hands) (HP:0001180)2.22906952
57Photophobia (HP:0000613)2.22859865
58Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.22260730
59Macular degeneration (HP:0000608)2.20950390
60Postaxial foot polydactyly (HP:0001830)2.20738297
61Pancreatic cysts (HP:0001737)2.18852559
62Diplopia (HP:0000651)2.18219636
63Abnormality of binocular vision (HP:0011514)2.18219636
64* Genital tract atresia (HP:0001827)2.18163826
65Nephronophthisis (HP:0000090)2.17243895
66* Vaginal atresia (HP:0000148)2.16782990
67* Broad foot (HP:0001769)2.16205812
68Tubulointerstitial nephritis (HP:0001970)2.15661398
69Febrile seizures (HP:0002373)2.15195595
70Limb dystonia (HP:0002451)2.13688007
71Depression (HP:0000716)2.13409406
72Dialeptic seizures (HP:0011146)2.13292065
73* Poor coordination (HP:0002370)2.13066264
74Spastic gait (HP:0002064)2.12886854
75Pendular nystagmus (HP:0012043)2.12296119
76Median cleft lip (HP:0000161)2.05990755
77Absence seizures (HP:0002121)2.05602798
78Prolonged QT interval (HP:0001657)2.04038948
79Abnormality of the fovea (HP:0000493)2.02960026
80Cerebellar dysplasia (HP:0007033)2.00869568
81Abnormality of the renal cortex (HP:0011035)2.00568686
82Insomnia (HP:0100785)1.99943063
83Constricted visual fields (HP:0001133)1.99520669
84Postural instability (HP:0002172)1.98870916
85Status epilepticus (HP:0002133)1.98657880
86EEG with generalized epileptiform discharges (HP:0011198)1.98349852
87* Specific learning disability (HP:0001328)1.98045057
88Retinal atrophy (HP:0001105)1.97331804
89Hyperinsulinemic hypoglycemia (HP:0000825)1.96779738
90Cystic liver disease (HP:0006706)1.96598932
91Papillary thyroid carcinoma (HP:0002895)1.95616687
92Increased circulating renin level (HP:0000848)1.95205824
93Hemiparesis (HP:0001269)1.94599113
94Epileptiform EEG discharges (HP:0011182)1.93004744
95Congenital hepatic fibrosis (HP:0002612)1.92459979
96Truncal ataxia (HP:0002078)1.91721861
97Progressive cerebellar ataxia (HP:0002073)1.91656232
98* Left ventricular hypertrophy (HP:0001712)1.91587647
99Hypsarrhythmia (HP:0002521)1.91400334
100Gaze-evoked nystagmus (HP:0000640)1.90479302
101Rhinitis (HP:0012384)1.89820214
102Symptomatic seizures (HP:0011145)1.89179730
103Abnormal EKG (HP:0003115)1.88777104
104Spastic tetraplegia (HP:0002510)1.88765680
105Prominent supraorbital ridges (HP:0000336)1.87371748
106Pheochromocytoma (HP:0002666)1.87286665
107Ventricular fibrillation (HP:0001663)1.87120037
108Hypoplasia of the fovea (HP:0007750)1.86068969
109Aplasia/Hypoplasia of the fovea (HP:0008060)1.86068969
110Abnormal eating behavior (HP:0100738)1.85105234
111Large for gestational age (HP:0001520)1.84685988
112Lower limb muscle weakness (HP:0007340)1.84518257
113Pigmentary retinal degeneration (HP:0001146)1.84283717
114* Postaxial hand polydactyly (HP:0001162)1.82655143
115Hyperglycinemia (HP:0002154)1.81836702
116* Short foot (HP:0001773)1.81075256
117Severe visual impairment (HP:0001141)1.80123779
118Male pseudohermaphroditism (HP:0000037)1.79674139
119Bile duct proliferation (HP:0001408)1.79332325
120Abnormal biliary tract physiology (HP:0012439)1.79332325
121Impaired smooth pursuit (HP:0007772)1.78938549
122Hypoglycemic seizures (HP:0002173)1.78904689
123Agitation (HP:0000713)1.78867264
124Lissencephaly (HP:0001339)1.78255814
125Exercise-induced muscle cramps (HP:0003710)1.78222326
126Split foot (HP:0001839)1.78015855
127Inability to walk (HP:0002540)1.76572640
128Neoplasm of the heart (HP:0100544)1.76462827
129Morphological abnormality of the pyramidal tract (HP:0002062)1.76226498
130Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.75924784
131Abnormality of the labia minora (HP:0012880)1.74413494
132Facial cleft (HP:0002006)1.73351543
133Chronic bronchitis (HP:0004469)1.73261731
134Rimmed vacuoles (HP:0003805)1.73241954
135Abnormality of calcium-phosphate metabolism (HP:0100530)1.71630203
136Atrophy/Degeneration involving motor neurons (HP:0007373)1.71483748
137Hyperaldosteronism (HP:0000859)1.71105185
138Impaired vibration sensation in the lower limbs (HP:0002166)1.70305347
139Hypoventilation (HP:0002791)1.68583936
140Polyphagia (HP:0002591)1.68320006
141Chronic hepatic failure (HP:0100626)1.68095252
142Dysdiadochokinesis (HP:0002075)1.67756701
143Polydipsia (HP:0001959)1.66459644
144Abnormal drinking behavior (HP:0030082)1.66459644
145Atonic seizures (HP:0010819)1.64891422
146Abnormality of the renal medulla (HP:0100957)1.62920554
147Aplasia/Hypoplasia of the tongue (HP:0010295)1.62612095
148* Aplasia/Hypoplasia of the lens (HP:0008063)1.61809752
149Cone-rod dystrophy (HP:0000548)1.61316501
150Abnormality of ocular smooth pursuit (HP:0000617)1.60309745

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKD33.57198035
2WNK33.50351986
3NTRK33.39056274
4EPHA43.32617517
5NTRK22.68127661
6PHKG22.54731589
7PHKG12.54731589
8FRK2.42238154
9MAP3K92.29580688
10LMTK22.25585569
11PAK62.05596443
12SGK22.01521643
13SGK2231.87392007
14SGK4941.87392007
15MAPK151.85071728
16PINK11.74491884
17MAP4K21.67964270
18AKT31.66029661
19PLK21.64835965
20BRD41.64409985
21EPHA31.61917425
22MAP3K41.57926971
23PAK31.52233874
24INSRR1.51672351
25UHMK11.50589774
26CAMKK21.48243067
27HIPK21.46894778
28KSR11.46307662
29MAP3K21.44355094
30SGK31.43869076
31TAOK31.43096267
32ERBB31.43002490
33CDK51.36937609
34MINK11.34470494
35DYRK1A1.34307914
36MAP2K71.34087333
37MARK11.32715524
38PDK41.29939682
39PDK31.29939682
40TNIK1.24309271
41BCR1.24023098
42MET1.23615029
43PRPF4B1.19308418
44WNK41.11489323
45NEK11.09895673
46STK391.08776032
47PRKCG1.07764324
48PASK1.05455594
49GRK11.04803357
50BMPR1B1.03213911
51PRKCH1.02596110
52TNK20.96873456
53KSR20.94712440
54DAPK20.93159126
55CCNB10.93114729
56OXSR10.92858831
57CSNK1G30.91061019
58CSNK1A1L0.90942380
59STK380.90669425
60LIMK10.90178642
61PNCK0.89210218
62CAMKK10.89101345
63MAPK130.88946682
64NEK60.88814086
65IRAK20.88103258
66BRAF0.85434183
67MAP2K60.84330876
68GRK50.83437305
69DYRK30.81363299
70NLK0.78656933
71CAMK2B0.78387108
72SIK20.76795220
73CDK30.76197998
74OBSCN0.76081502
75CDK190.74703399
76PKN10.74447319
77BCKDK0.74088549
78CDC42BPA0.73823047
79ARAF0.73591098
80WNK10.73400666
81PRKAA10.72316439
82MAPK100.71995002
83FGR0.71931583
84NTRK10.70597640
85CAMK1G0.69864944
86TYRO30.69607384
87ADRBK20.69383445
88DYRK1B0.68798238
89NEK90.67942352
90MAPKAPK50.66898455
91RET0.64349100
92PIK3CA0.63653266
93CAMK10.62266220
94FER0.62191317
95RPS6KA30.60810775
96ERBB20.59100750
97CDK180.59033706
98BMX0.58957788
99SGK10.58802748
100CDK150.57608927
101CDK120.56886188
102ICK0.55973213
103CAMK2A0.55754857
104EPHB10.55750651
105CSNK1G20.55285198
106CDK140.54536854
107DYRK20.54398797
108CASK0.52950006
109CAMK40.51398615
110PRKCZ0.50129496
111PRKCE0.49712974
112MAPKAPK30.48198864
113BRSK10.48046847
114MAP2K40.47911748
115CDK11A0.46535183
116MARK20.46369551
117CAMK1D0.46098791
118MAPK70.45486337
119PDGFRB0.43995446
120GSK3B0.43680621
121ROCK20.42813968
122PRKACA0.42697636
123CSNK1A10.41784730
124PRKD20.40615282
125FGFR20.40146966
126STK110.40060298
127PDK20.39786822
128PTK2B0.38639704
129CAMK2D0.38304267
130STK38L0.37647907
131CSNK1G10.37437887
132PRKACG0.37169203
133SCYL20.36951635
134CAMK2G0.36915460
135RPS6KB10.36652946
136PRKACB0.36341953
137NEK20.35780073
138DAPK10.35459897
139PRKDC0.35392187
140ADRBK10.35343572
141MAP3K10.34193383

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047445.38789075
2Olfactory transduction_Homo sapiens_hsa047402.91653219
3Insulin secretion_Homo sapiens_hsa049112.79389819
4Synaptic vesicle cycle_Homo sapiens_hsa047212.78710699
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.62941978
6Nicotine addiction_Homo sapiens_hsa050332.55918266
7GABAergic synapse_Homo sapiens_hsa047272.39463802
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.39417067
9Circadian entrainment_Homo sapiens_hsa047132.31236724
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.26016421
11Amphetamine addiction_Homo sapiens_hsa050312.06712747
12Morphine addiction_Homo sapiens_hsa050322.04285036
13Butanoate metabolism_Homo sapiens_hsa006502.04001725
14Cocaine addiction_Homo sapiens_hsa050302.00317840
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.99491411
16Glutamatergic synapse_Homo sapiens_hsa047241.98142385
17Circadian rhythm_Homo sapiens_hsa047101.95430339
18Propanoate metabolism_Homo sapiens_hsa006401.91968394
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.88864434
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.87679356
21Dopaminergic synapse_Homo sapiens_hsa047281.87222630
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.84869075
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.83291166
24Long-term potentiation_Homo sapiens_hsa047201.79765492
25Taste transduction_Homo sapiens_hsa047421.76964519
26Fatty acid elongation_Homo sapiens_hsa000621.73815003
27Fatty acid metabolism_Homo sapiens_hsa012121.72406008
28beta-Alanine metabolism_Homo sapiens_hsa004101.66748352
29Cholinergic synapse_Homo sapiens_hsa047251.53320979
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.44990096
31Renin secretion_Homo sapiens_hsa049241.30629297
32Type II diabetes mellitus_Homo sapiens_hsa049301.29918756
33Salivary secretion_Homo sapiens_hsa049701.28543725
34Serotonergic synapse_Homo sapiens_hsa047261.28438087
35Glucagon signaling pathway_Homo sapiens_hsa049221.25497769
36Ether lipid metabolism_Homo sapiens_hsa005651.23054892
37Gastric acid secretion_Homo sapiens_hsa049711.22734033
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.22409550
39ABC transporters_Homo sapiens_hsa020101.22187950
40Histidine metabolism_Homo sapiens_hsa003401.21566431
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20075380
42cAMP signaling pathway_Homo sapiens_hsa040241.18967630
43Vibrio cholerae infection_Homo sapiens_hsa051101.18203030
44Collecting duct acid secretion_Homo sapiens_hsa049661.15525760
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.14735035
46Steroid biosynthesis_Homo sapiens_hsa001001.14699690
47Calcium signaling pathway_Homo sapiens_hsa040201.12355560
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07706610
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07147488
50Oocyte meiosis_Homo sapiens_hsa041141.02252625
51cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01351744
52Peroxisome_Homo sapiens_hsa041461.00829894
53Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00246916
54Linoleic acid metabolism_Homo sapiens_hsa005910.98462770
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.97762986
56Pancreatic secretion_Homo sapiens_hsa049720.96416055
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94934882
58Alcoholism_Homo sapiens_hsa050340.93475165
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91151440
60Oxytocin signaling pathway_Homo sapiens_hsa049210.91139848
61Ovarian steroidogenesis_Homo sapiens_hsa049130.89966811
62Melanogenesis_Homo sapiens_hsa049160.89899385
63Thyroid hormone synthesis_Homo sapiens_hsa049180.89631310
64Gap junction_Homo sapiens_hsa045400.88082641
65GnRH signaling pathway_Homo sapiens_hsa049120.87712880
66Fatty acid degradation_Homo sapiens_hsa000710.83865624
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.81898233
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80942702
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80384428
70Estrogen signaling pathway_Homo sapiens_hsa049150.80318514
71Bile secretion_Homo sapiens_hsa049760.78497171
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77811117
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72740061
74N-Glycan biosynthesis_Homo sapiens_hsa005100.71228755
75mRNA surveillance pathway_Homo sapiens_hsa030150.70869920
76Fatty acid biosynthesis_Homo sapiens_hsa000610.70045936
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69280659
78Basal transcription factors_Homo sapiens_hsa030220.68628871
79Dorso-ventral axis formation_Homo sapiens_hsa043200.68562356
80Tryptophan metabolism_Homo sapiens_hsa003800.67196446
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.66995473
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66709307
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66470351
84Inositol phosphate metabolism_Homo sapiens_hsa005620.66354161
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65694583
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65663000
87Nitrogen metabolism_Homo sapiens_hsa009100.65468007
88Long-term depression_Homo sapiens_hsa047300.65145326
89Sphingolipid metabolism_Homo sapiens_hsa006000.64502314
90Lysine degradation_Homo sapiens_hsa003100.64169639
91Hedgehog signaling pathway_Homo sapiens_hsa043400.63291814
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62986177
93Axon guidance_Homo sapiens_hsa043600.61638820
94mTOR signaling pathway_Homo sapiens_hsa041500.61228864
95Wnt signaling pathway_Homo sapiens_hsa043100.61195942
96Insulin signaling pathway_Homo sapiens_hsa049100.60989214
97Arginine and proline metabolism_Homo sapiens_hsa003300.60515523
98Glycerolipid metabolism_Homo sapiens_hsa005610.60360537
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.57797794
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56030641
101Dilated cardiomyopathy_Homo sapiens_hsa054140.55808230
102Purine metabolism_Homo sapiens_hsa002300.54703641
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54448997
104Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53308299
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52617238
106Type I diabetes mellitus_Homo sapiens_hsa049400.51808087
107PPAR signaling pathway_Homo sapiens_hsa033200.51307487
108Basal cell carcinoma_Homo sapiens_hsa052170.51229127
109Endometrial cancer_Homo sapiens_hsa052130.50726393
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49822662
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48305241
112ErbB signaling pathway_Homo sapiens_hsa040120.47296606
113MAPK signaling pathway_Homo sapiens_hsa040100.45843696
114Notch signaling pathway_Homo sapiens_hsa043300.45473736
115Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45087754
116Ras signaling pathway_Homo sapiens_hsa040140.44541683
117Protein export_Homo sapiens_hsa030600.43880782
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43403673
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43338918
120Cardiac muscle contraction_Homo sapiens_hsa042600.43262277
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43215720
122Hippo signaling pathway_Homo sapiens_hsa043900.42265366
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.41201717
124RNA polymerase_Homo sapiens_hsa030200.39697996
125Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39547855
126Choline metabolism in cancer_Homo sapiens_hsa052310.39481489
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38647442
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37991017
129Regulation of autophagy_Homo sapiens_hsa041400.37468365
130Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37039546
131Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36977424
132Glioma_Homo sapiens_hsa052140.36922570
133Tight junction_Homo sapiens_hsa045300.36653725
134Endocytosis_Homo sapiens_hsa041440.36098873
135Vitamin B6 metabolism_Homo sapiens_hsa007500.34223984
136Lysosome_Homo sapiens_hsa041420.34070433

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