BBS4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by severe pigmentary retinopathy, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse. The similar phenotypes exhibited by mutations in BBS gene family members are likely due to the protein's shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene has sequence similarity to O-linked N-acetylglucosamine (O-GlcNAc) transferases in plants and archaebacteria and in human forms a multi-protein 'BBSome' complex with seven other BBS proteins. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)4.92481232
2neuron cell-cell adhesion (GO:0007158)4.78370840
3protein localization to synapse (GO:0035418)4.71554403
4epithelial cilium movement (GO:0003351)4.58027046
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.56363607
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.50683027
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.49843561
8glutamate secretion (GO:0014047)4.40100724
9intraciliary transport (GO:0042073)4.39839990
10cilium movement (GO:0003341)4.39136891
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.36413934
12vocalization behavior (GO:0071625)4.35324230
13axonemal dynein complex assembly (GO:0070286)4.18480981
14* nonmotile primary cilium assembly (GO:0035058)4.11760146
15synaptic vesicle maturation (GO:0016188)4.09171049
16regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.07781568
17regulation of rhodopsin mediated signaling pathway (GO:0022400)4.06532270
18regulation of synaptic vesicle exocytosis (GO:2000300)4.01533362
19regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.00431340
20response to histamine (GO:0034776)3.98484124
21synaptic vesicle docking involved in exocytosis (GO:0016081)3.97996783
22* regulation of cilium movement (GO:0003352)3.93809299
23rhodopsin mediated signaling pathway (GO:0016056)3.88137791
24axoneme assembly (GO:0035082)3.85201254
25neuron-neuron synaptic transmission (GO:0007270)3.85041384
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.83834906
27proline transport (GO:0015824)3.80925228
28neurotransmitter-gated ion channel clustering (GO:0072578)3.80770054
29polyketide metabolic process (GO:0030638)3.76688207
30doxorubicin metabolic process (GO:0044598)3.76688207
31daunorubicin metabolic process (GO:0044597)3.76688207
32neuronal action potential propagation (GO:0019227)3.71984216
33gamma-aminobutyric acid signaling pathway (GO:0007214)3.68019595
34retinal cone cell development (GO:0046549)3.66388874
35synaptic transmission, glutamatergic (GO:0035249)3.65729737
36regulation of glutamate receptor signaling pathway (GO:1900449)3.65167899
37regulation of synaptic vesicle transport (GO:1902803)3.61921684
38behavioral response to cocaine (GO:0048148)3.60704785
39regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.59974001
40regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.59974001
41neurotransmitter secretion (GO:0007269)3.58001578
42protein localization to cilium (GO:0061512)3.56565845
43* cilium morphogenesis (GO:0060271)3.54998103
44long-term synaptic potentiation (GO:0060291)3.51369647
45glutamate receptor signaling pathway (GO:0007215)3.47247925
46synaptic vesicle endocytosis (GO:0048488)3.46609414
47presynaptic membrane assembly (GO:0097105)3.46362976
48neurotransmitter transport (GO:0006836)3.40446088
49G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.40417479
50positive regulation of synapse maturation (GO:0090129)3.36600008
51* cilium organization (GO:0044782)3.35746533
52behavioral defense response (GO:0002209)3.33625813
53behavioral fear response (GO:0001662)3.33625813
54cilium or flagellum-dependent cell motility (GO:0001539)3.32641720
55* cilium assembly (GO:0042384)3.32231137
56ionotropic glutamate receptor signaling pathway (GO:0035235)3.27682411
57presynaptic membrane organization (GO:0097090)3.27366443
58synaptic transmission, dopaminergic (GO:0001963)3.27276794
59pyrimidine nucleobase catabolic process (GO:0006208)3.23340317
60neuron recognition (GO:0008038)3.23217488
61negative regulation of synaptic transmission, GABAergic (GO:0032229)3.21968724
62postsynaptic membrane organization (GO:0001941)3.20690017
63fear response (GO:0042596)3.20112002
64female mating behavior (GO:0060180)3.18942470
65positive regulation of membrane potential (GO:0045838)3.10771322
66aldehyde catabolic process (GO:0046185)3.09455715
67startle response (GO:0001964)3.08204425
68positive regulation of neurotransmitter transport (GO:0051590)3.07940151
69resolution of meiotic recombination intermediates (GO:0000712)3.07614771
70DNA double-strand break processing (GO:0000729)3.06444066
71positive regulation of mitochondrial fission (GO:0090141)3.05476008
72regulation of long-term neuronal synaptic plasticity (GO:0048169)3.05070796
73regulation of excitatory postsynaptic membrane potential (GO:0060079)3.04692680
74regulation of neurotransmitter secretion (GO:0046928)3.04292791
75regulation of neurotransmitter uptake (GO:0051580)3.03708657
76regulation of postsynaptic membrane potential (GO:0060078)3.02852835
77* photoreceptor cell development (GO:0042461)3.02086991
78cullin deneddylation (GO:0010388)3.01953927
79microtubule severing (GO:0051013)2.99676205
80energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.99382499
81ATP hydrolysis coupled proton transport (GO:0015991)2.99382499
82calcium-mediated signaling using intracellular calcium source (GO:0035584)2.98727641
83mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.98378390
84membrane hyperpolarization (GO:0060081)2.98368427
85regulation of synaptic transmission, glutamatergic (GO:0051966)2.97749535
86positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.97277928
87regulation of neuronal synaptic plasticity (GO:0048168)2.97205964
88regulation of female receptivity (GO:0045924)2.95212916
89cerebellar granule cell differentiation (GO:0021707)2.93976073
90* eye photoreceptor cell development (GO:0042462)2.92154735
91regulation of neurotransmitter transport (GO:0051588)2.90658808
92establishment of protein localization to mitochondrial membrane (GO:0090151)2.90377478
93behavioral response to ethanol (GO:0048149)2.88704039
94regulation of neurotransmitter levels (GO:0001505)2.87402362
95phenol-containing compound catabolic process (GO:0019336)2.86058766
96respiratory chain complex IV assembly (GO:0008535)2.85752047
97synapse assembly (GO:0007416)2.84969691
98negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.84240135
99locomotory exploration behavior (GO:0035641)2.83921655
100membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.83542908
101innervation (GO:0060384)2.82773008
102regulation of voltage-gated calcium channel activity (GO:1901385)2.82443350
103synapsis (GO:0007129)2.82178764
104water-soluble vitamin biosynthetic process (GO:0042364)2.81809605
105regulation of synapse maturation (GO:0090128)2.81665802
106protein deneddylation (GO:0000338)2.81655912
107regulation of vesicle fusion (GO:0031338)2.80945869
108synaptic transmission (GO:0007268)2.80068977
109long-term memory (GO:0007616)2.79829067
110transferrin transport (GO:0033572)2.79065463
111detection of light stimulus involved in sensory perception (GO:0050962)2.78808343
112detection of light stimulus involved in visual perception (GO:0050908)2.78808343
113establishment of synaptic vesicle localization (GO:0097480)2.78219163
114synaptic vesicle transport (GO:0048489)2.78219163
115protein complex biogenesis (GO:0070271)2.77855171
116ubiquinone metabolic process (GO:0006743)2.77748494
117neurotransmitter uptake (GO:0001504)2.76926225
118axonal fasciculation (GO:0007413)2.76720503
119detection of calcium ion (GO:0005513)2.76659056
120protein polyglutamylation (GO:0018095)2.76394075
121retinal ganglion cell axon guidance (GO:0031290)2.75715633
122mating behavior (GO:0007617)2.75614575
123positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.74384123
124* regulation of microtubule-based movement (GO:0060632)2.74156871
125positive regulation of synapse assembly (GO:0051965)2.74113076
126* photoreceptor cell maintenance (GO:0045494)2.73967464
127positive regulation of synaptic transmission (GO:0050806)2.73826193
128* establishment of vesicle localization (GO:0051650)2.73604841
129chromatin remodeling at centromere (GO:0031055)2.73390937
130ubiquinone biosynthetic process (GO:0006744)2.70334921
131behavioral response to nicotine (GO:0035095)2.67666597
132mitochondrial respiratory chain complex I assembly (GO:0032981)2.66879991
133NADH dehydrogenase complex assembly (GO:0010257)2.66879991
134mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.66879991
135histone H2A acetylation (GO:0043968)2.66605718
136smoothened signaling pathway (GO:0007224)2.65482413
137microtubule bundle formation (GO:0001578)2.64935010
138somite development (GO:0061053)2.63899626
139energy coupled proton transport, down electrochemical gradient (GO:0015985)2.63896871
140ATP synthesis coupled proton transport (GO:0015986)2.63896871
141mitochondrial respiratory chain complex assembly (GO:0033108)2.63480265
142nucleobase catabolic process (GO:0046113)2.61222979
143protein-cofactor linkage (GO:0018065)2.60910910
144* cellular component assembly involved in morphogenesis (GO:0010927)2.60688079
145protein neddylation (GO:0045116)2.57073297
146isoprenoid biosynthetic process (GO:0008299)2.56822883
147mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.56046119
148centriole replication (GO:0007099)2.54867963
149motile cilium assembly (GO:0044458)2.52215924
150substrate-independent telencephalic tangential migration (GO:0021826)2.51184710
151substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.51184710
152left/right pattern formation (GO:0060972)2.49299238
153olfactory bulb development (GO:0021772)2.47951819
154cytochrome complex assembly (GO:0017004)2.45899538
155cholesterol biosynthetic process (GO:0006695)2.43388777
156CENP-A containing nucleosome assembly (GO:0034080)2.41525186
157branched-chain amino acid catabolic process (GO:0009083)2.41308371
158sterol biosynthetic process (GO:0016126)2.40982072
159left/right axis specification (GO:0070986)2.38450705
160regulation of collateral sprouting (GO:0048670)2.37915610
161organelle disassembly (GO:1903008)2.36414523
162proteasome assembly (GO:0043248)2.35331954
163DNA damage response, detection of DNA damage (GO:0042769)2.35112887
164tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.34600783
165RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.34600783
166negative regulation of transcription regulatory region DNA binding (GO:2000678)2.33965133
167nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.30465957
168short-term memory (GO:0007614)2.24823679
169protein K6-linked ubiquitination (GO:0085020)2.23877578
170negative regulation of DNA recombination (GO:0045910)2.23609692
171replication fork processing (GO:0031297)2.23350320
172hindbrain development (GO:0030902)2.22370631
173lysine catabolic process (GO:0006554)2.20369208
174lysine metabolic process (GO:0006553)2.20369208
175reciprocal meiotic recombination (GO:0007131)2.20147259
176reciprocal DNA recombination (GO:0035825)2.20147259
177regulation of meiosis I (GO:0060631)2.19420412
178piRNA metabolic process (GO:0034587)2.18852477
179aspartate family amino acid catabolic process (GO:0009068)2.18791749
180negative regulation of DNA-dependent DNA replication (GO:2000104)2.18589165
181C4-dicarboxylate transport (GO:0015740)2.18243795
182exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.18184136
183chaperone-mediated protein transport (GO:0072321)2.18010510
184microtubule depolymerization (GO:0007019)2.17919532
185regulation of timing of cell differentiation (GO:0048505)2.16605345
186regulation of development, heterochronic (GO:0040034)2.16432634
187histone exchange (GO:0043486)2.16162708
188transmission of nerve impulse (GO:0019226)2.15879338
189ribosomal small subunit assembly (GO:0000028)2.14749187
190axon extension involved in axon guidance (GO:0048846)2.14554927
191neuron projection extension involved in neuron projection guidance (GO:1902284)2.14554927

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.19358722
2GBX2_23144817_ChIP-Seq_PC3_Human3.80933729
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.38602137
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.14067888
5ZNF274_21170338_ChIP-Seq_K562_Hela2.95220417
6* GABP_17652178_ChIP-ChIP_JURKAT_Human2.94308685
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.75566750
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.63683753
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.61785723
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.61279338
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.57685475
12REST_21632747_ChIP-Seq_MESCs_Mouse2.49261906
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.38198387
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.37359897
15TAF15_26573619_Chip-Seq_HEK293_Human2.36471745
16BMI1_23680149_ChIP-Seq_NPCS_Mouse2.29475774
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.27594651
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.18145890
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.18145890
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.14006026
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.13251892
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.11572295
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.09479100
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09358948
25CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08712893
26* VDR_22108803_ChIP-Seq_LS180_Human2.07378336
27* ELK1_19687146_ChIP-ChIP_HELA_Human2.07237037
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.06737420
29RNF2_27304074_Chip-Seq_NSC_Mouse2.06397978
30IGF1R_20145208_ChIP-Seq_DFB_Human2.04884085
31JARID2_20075857_ChIP-Seq_MESCs_Mouse2.03075626
32CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02260410
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.95711658
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95678334
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.93297301
36SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.92408315
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.90694342
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.90491420
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.85822519
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.83681094
41EWS_26573619_Chip-Seq_HEK293_Human1.83548986
42MTF2_20144788_ChIP-Seq_MESCs_Mouse1.82628310
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78968774
44RARB_27405468_Chip-Seq_BRAIN_Mouse1.77913509
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.77610961
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.76123149
47SMAD4_21799915_ChIP-Seq_A2780_Human1.74786837
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.71126846
49ETS1_20019798_ChIP-Seq_JURKAT_Human1.68141048
50SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66814367
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.65226427
52JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.64010526
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63452641
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62919381
55E2F4_17652178_ChIP-ChIP_JURKAT_Human1.61215549
56FUS_26573619_Chip-Seq_HEK293_Human1.60524010
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57782171
58P300_19829295_ChIP-Seq_ESCs_Human1.57177100
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50360950
60VDR_23849224_ChIP-Seq_CD4+_Human1.49799358
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48811093
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47642645
63CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.45818221
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.39266622
65MYC_18940864_ChIP-ChIP_HL60_Human1.38845140
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37304033
67PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36068799
68CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34892915
69NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.31936831
70KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.31316312
71KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.31316312
72KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.31316312
73* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.29635418
74* STAT3_23295773_ChIP-Seq_U87_Human1.29142383
75* PIAS1_25552417_ChIP-Seq_VCAP_Human1.27640844
76RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.25993653
77SRF_21415370_ChIP-Seq_HL-1_Mouse1.25944991
78CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.25538102
79FLI1_27457419_Chip-Seq_LIVER_Mouse1.23553237
80PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22753957
81SOX2_16153702_ChIP-ChIP_HESCs_Human1.22696721
82AR_21572438_ChIP-Seq_LNCaP_Human1.22012961
83SOX2_21211035_ChIP-Seq_LN229_Gbm1.21736526
84FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.21469460
85YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19920145
86* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19454449
87* CBP_20019798_ChIP-Seq_JUKART_Human1.19454449
88DROSHA_22980978_ChIP-Seq_HELA_Human1.19437412
89AR_25329375_ChIP-Seq_VCAP_Human1.19111478
90FOXP3_21729870_ChIP-Seq_TREG_Human1.18514034
91* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17589057
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.17494417
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17283058
94IRF1_19129219_ChIP-ChIP_H3396_Human1.16674519
95TP53_22573176_ChIP-Seq_HFKS_Human1.16530754
96* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16327796
97* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16126765
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14769653
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14769653
100KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14041772
101ER_23166858_ChIP-Seq_MCF-7_Human1.12604236
102OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12495568
103JUN_21703547_ChIP-Seq_K562_Human1.11109950
104SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10215040
105TTF2_22483619_ChIP-Seq_HELA_Human1.10086922
106RUNX2_22187159_ChIP-Seq_PCA_Human1.09928069
107TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09919873
108* GABP_19822575_ChIP-Seq_HepG2_Human1.09157717
109NANOG_16153702_ChIP-ChIP_HESCs_Human1.08549345
110RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06484725
111ELK4_26923725_Chip-Seq_MESODERM_Mouse1.05945974
112TCF4_23295773_ChIP-Seq_U87_Human1.05591569
113POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04988655
114PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04286745
115* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02953070
116BCAT_22108803_ChIP-Seq_LS180_Human1.02396086
117AR_19668381_ChIP-Seq_PC3_Human1.01524102
118MYC_18555785_ChIP-Seq_MESCs_Mouse1.01167759
119FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00843006
120TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00770760
121RING1B_27294783_Chip-Seq_NPCs_Mouse1.00375482
122ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99779512
123NANOG_18555785_Chip-Seq_ESCs_Mouse0.99141675
124TCF4_22108803_ChIP-Seq_LS180_Human0.98644456
125SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98380099
126BP1_19119308_ChIP-ChIP_Hs578T_Human0.97535165
127PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97326713
128ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97015072
129RING1B_27294783_Chip-Seq_ESCs_Mouse0.96281203
130KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96129550
131RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96067690
132EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95630546
133NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95090848
134* E2F1_17053090_ChIP-ChIP_MCF-7_Human0.94842612
135EZH2_27294783_Chip-Seq_NPCs_Mouse0.94630915
136* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94111532
137ERG_21242973_ChIP-ChIP_JURKAT_Human0.93824054
138PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93081031
139SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93032471
140LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92460370
141ARNT_22903824_ChIP-Seq_MCF-7_Human0.92338773
142TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92229496
143PRDM14_20953172_ChIP-Seq_ESCs_Human0.92076728
144GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92016387
145EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92012112
146STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91922508
147SOX2_19829295_ChIP-Seq_ESCs_Human0.91509949
148NANOG_19829295_ChIP-Seq_ESCs_Human0.91509949
149SMAD_19615063_ChIP-ChIP_OVARY_Human0.91415157
150GATA1_26923725_Chip-Seq_HPCs_Mouse0.91040078
151NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.89622602

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.09975017
2MP0004859_abnormal_synaptic_plasticity3.76589131
3MP0003635_abnormal_synaptic_transmissio3.05687401
4MP0004270_analgesia2.89340181
5MP0009046_muscle_twitch2.84453848
6* MP0005551_abnormal_eye_electrophysiolog2.76221021
7MP0009745_abnormal_behavioral_response2.61824658
8MP0002064_seizures2.61501277
9MP0002063_abnormal_learning/memory/cond2.60350670
10MP0010030_abnormal_orbit_morphology2.51912229
11* MP0002572_abnormal_emotion/affect_behav2.46862480
12MP0002272_abnormal_nervous_system2.44807319
13MP0005423_abnormal_somatic_nervous2.44279219
14MP0001968_abnormal_touch/_nociception2.43767316
15MP0003011_delayed_dark_adaptation2.39109101
16MP0003122_maternal_imprinting2.37963430
17MP0006292_abnormal_olfactory_placode2.34919728
18MP0003787_abnormal_imprinting2.34510718
19MP0002938_white_spotting2.27892314
20MP0001486_abnormal_startle_reflex2.26026754
21* MP0002734_abnormal_mechanical_nocicepti2.20099922
22MP0003136_yellow_coat_color2.16305011
23MP0000566_synostosis2.13836976
24MP0006072_abnormal_retinal_apoptosis2.13498194
25MP0006276_abnormal_autonomic_nervous2.07822389
26MP0001501_abnormal_sleep_pattern2.07716018
27MP0001529_abnormal_vocalization2.06071505
28* MP0005499_abnormal_olfactory_system2.04084158
29* MP0005394_taste/olfaction_phenotype2.04084158
30MP0002736_abnormal_nociception_after2.01765276
31MP0008058_abnormal_DNA_repair2.01346672
32MP0005646_abnormal_pituitary_gland2.00190780
33MP0005253_abnormal_eye_physiology1.97559635
34MP0001440_abnormal_grooming_behavior1.92979358
35MP0004858_abnormal_nervous_system1.89560383
36MP0002067_abnormal_sensory_capabilities1.87767896
37MP0001905_abnormal_dopamine_level1.85218690
38MP0001293_anophthalmia1.84975687
39MP0002735_abnormal_chemical_nociception1.84658951
40MP0002184_abnormal_innervation1.81886815
41MP0002653_abnormal_ependyma_morphology1.78461228
42MP0001188_hyperpigmentation1.75753569
43MP0002822_catalepsy1.74312574
44* MP0001984_abnormal_olfaction1.71428885
45MP0002733_abnormal_thermal_nociception1.71325302
46MP0004133_heterotaxia1.70177611
47* MP0001970_abnormal_pain_threshold1.62091145
48MP0005645_abnormal_hypothalamus_physiol1.59181708
49MP0003121_genomic_imprinting1.57143287
50MP0000778_abnormal_nervous_system1.57046665
51* MP0002557_abnormal_social/conspecific_i1.53935502
52MP0001986_abnormal_taste_sensitivity1.53434902
53MP0004924_abnormal_behavior1.46076948
54MP0005386_behavior/neurological_phenoty1.46076948
55* MP0002882_abnormal_neuron_morphology1.45463752
56MP0003937_abnormal_limbs/digits/tail_de1.44175272
57MP0004142_abnormal_muscle_tone1.43865584
58MP0005248_abnormal_Harderian_gland1.43759304
59* MP0002233_abnormal_nose_morphology1.40935339
60MP0000955_abnormal_spinal_cord1.36061433
61* MP0002752_abnormal_somatic_nervous1.34295113
62MP0000631_abnormal_neuroendocrine_gland1.31283235
63MP0002876_abnormal_thyroid_physiology1.29726345
64MP0003183_abnormal_peptide_metabolism1.29492630
65MP0003879_abnormal_hair_cell1.28957489
66MP0002229_neurodegeneration1.28347916
67MP0001502_abnormal_circadian_rhythm1.24986522
68MP0001485_abnormal_pinna_reflex1.21482685
69MP0001299_abnormal_eye_distance/1.20195491
70MP0008877_abnormal_DNA_methylation1.17541442
71MP0002638_abnormal_pupillary_reflex1.16958358
72MP0003755_abnormal_palate_morphology1.15424678
73MP0002332_abnormal_exercise_endurance1.14687725
74MP0002234_abnormal_pharynx_morphology1.14184224
75MP0003718_maternal_effect1.13082708
76MP0004811_abnormal_neuron_physiology1.13021177
77MP0008932_abnormal_embryonic_tissue1.12200740
78* MP0002066_abnormal_motor_capabilities/c1.12091757
79MP0003693_abnormal_embryo_hatching1.11441568
80MP0002909_abnormal_adrenal_gland1.11281307
81MP0001963_abnormal_hearing_physiology1.10523829
82MP0003567_abnormal_fetal_cardiomyocyte1.10417191
83MP0003890_abnormal_embryonic-extraembry1.09941890
84MP0008569_lethality_at_weaning1.09767368
85* MP0005195_abnormal_posterior_eye1.07353264
86* MP0008789_abnormal_olfactory_epithelium1.07316352
87MP0002751_abnormal_autonomic_nervous1.06581905
88MP0010386_abnormal_urinary_bladder1.05797923
89MP0006035_abnormal_mitochondrial_morpho1.03649977
90MP0008872_abnormal_physiological_respon1.03125627
91MP0010094_abnormal_chromosome_stability1.03109960
92MP0000647_abnormal_sebaceous_gland1.02761624
93MP0001286_abnormal_eye_development1.01401550
94MP0002210_abnormal_sex_determination1.01366946
95MP0004043_abnormal_pH_regulation1.01233116
96MP0004147_increased_porphyrin_level1.00416239
97MP0009780_abnormal_chondrocyte_physiolo0.98768881
98MP0002254_reproductive_system_inflammat0.98757568
99MP0002160_abnormal_reproductive_system0.98685996
100MP0002090_abnormal_vision0.98134019
101MP0005187_abnormal_penis_morphology0.97651328
102* MP0002152_abnormal_brain_morphology0.97140989
103MP0003329_amyloid_beta_deposits0.97067249
104MP0003938_abnormal_ear_development0.93844275
105MP0004145_abnormal_muscle_electrophysio0.93207121
106* MP0001929_abnormal_gametogenesis0.90873967
107MP0002127_abnormal_cardiovascular_syste0.89746705
108MP0004085_abnormal_heartbeat0.87829888
109MP0000516_abnormal_urinary_system0.87826522
110MP0005367_renal/urinary_system_phenotyp0.87826522
111MP0000653_abnormal_sex_gland0.86942869
112* MP0003698_abnormal_male_reproductive0.86014532
113MP0002837_dystrophic_cardiac_calcinosis0.84386753
114MP0005391_vision/eye_phenotype0.83966295
115MP0003646_muscle_fatigue0.83790458
116MP0001145_abnormal_male_reproductive0.83603079
117MP0003123_paternal_imprinting0.83463594
118MP0003186_abnormal_redox_activity0.83264596
119MP0003942_abnormal_urinary_system0.82620477
120* MP0001324_abnormal_eye_pigmentation0.82020876
121MP0000678_abnormal_parathyroid_gland0.81089713
122MP0003119_abnormal_digestive_system0.80430027
123MP0002697_abnormal_eye_size0.79793317
124* MP0000026_abnormal_inner_ear0.78855795
125MP0000372_irregular_coat_pigmentation0.78412312
126MP0004264_abnormal_extraembryonic_tissu0.78105699
127MP0005084_abnormal_gallbladder_morpholo0.77088532
128MP0002282_abnormal_trachea_morphology0.76556351
129MP0002928_abnormal_bile_duct0.76121599
130* MP0002069_abnormal_eating/drinking_beha0.73235728
131MP0003634_abnormal_glial_cell0.73032357
132* MP0003861_abnormal_nervous_system0.70818721
133MP0004885_abnormal_endolymph0.70440356
134MP0004742_abnormal_vestibular_system0.68902266
135MP0003633_abnormal_nervous_system0.68584422
136MP0003137_abnormal_impulse_conducting0.67865265
137MP0005410_abnormal_fertilization0.66603155
138MP0004233_abnormal_muscle_weight0.65056260
139MP0005379_endocrine/exocrine_gland_phen0.64229343
140MP0002102_abnormal_ear_morphology0.61794150
141MP0000049_abnormal_middle_ear0.61202852

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)5.38485026
2Focal motor seizures (HP:0011153)5.37369314
3Febrile seizures (HP:0002373)4.80159140
4Atonic seizures (HP:0010819)4.71701977
5Epileptic encephalopathy (HP:0200134)4.64341296
6* Gait imbalance (HP:0002141)4.08431199
7Focal seizures (HP:0007359)4.05244344
8Hyperventilation (HP:0002883)3.95848562
9* Congenital primary aphakia (HP:0007707)3.85090719
10* Medial flaring of the eyebrow (HP:0010747)3.68851436
11Absence seizures (HP:0002121)3.60314001
12Nephronophthisis (HP:0000090)3.57845686
13Dialeptic seizures (HP:0011146)3.57609600
14* Nephrogenic diabetes insipidus (HP:0009806)3.49323659
15Myokymia (HP:0002411)3.46671402
16Abnormal ciliary motility (HP:0012262)3.33302640
17Abnormal respiratory motile cilium physiology (HP:0012261)3.24810504
18Visual hallucinations (HP:0002367)3.23923090
19Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.22107774
20Bony spicule pigmentary retinopathy (HP:0007737)3.19905224
21Hyperglycinemia (HP:0002154)3.12529198
22Bilateral microphthalmos (HP:0007633)3.10166565
23Progressive cerebellar ataxia (HP:0002073)3.09795977
24Generalized tonic-clonic seizures (HP:0002069)3.07130495
25* Genital tract atresia (HP:0001827)3.04500703
26Abnormal rod and cone electroretinograms (HP:0008323)2.99814954
27Aplasia/Hypoplasia of the tongue (HP:0010295)2.96643588
28* Vaginal atresia (HP:0000148)2.95770647
29Amblyopia (HP:0000646)2.87214901
30* Poor coordination (HP:0002370)2.83503113
31Abnormality of the renal medulla (HP:0100957)2.81814529
32Cystic liver disease (HP:0006706)2.78561158
33Postaxial foot polydactyly (HP:0001830)2.77034553
34Molar tooth sign on MRI (HP:0002419)2.71233993
35Abnormality of midbrain morphology (HP:0002418)2.71233993
36Tubulointerstitial nephritis (HP:0001970)2.63957902
37Occipital encephalocele (HP:0002085)2.63265256
38Sclerocornea (HP:0000647)2.62913274
39Limb dystonia (HP:0002451)2.59690341
40Abnormality of macular pigmentation (HP:0008002)2.59315198
41Anencephaly (HP:0002323)2.57474757
42Pancreatic fibrosis (HP:0100732)2.56531652
43Chronic hepatic failure (HP:0100626)2.55846402
44Abnormality of the lower motor neuron (HP:0002366)2.52278714
45Dyschromatopsia (HP:0007641)2.51441057
46Rhinitis (HP:0012384)2.49003474
47Central scotoma (HP:0000603)2.47369236
48Abnormal respiratory motile cilium morphology (HP:0005938)2.46936357
49Abnormal respiratory epithelium morphology (HP:0012253)2.46936357
50Hypoplasia of the fovea (HP:0007750)2.43570789
51Aplasia/Hypoplasia of the fovea (HP:0008060)2.43570789
52Preaxial hand polydactyly (HP:0001177)2.41967125
53Bifid tongue (HP:0010297)2.40624462
54Acute encephalopathy (HP:0006846)2.40438817
55Dynein arm defect of respiratory motile cilia (HP:0012255)2.40413348
56Absent/shortened dynein arms (HP:0200106)2.40413348
57Horizontal nystagmus (HP:0000666)2.39557086
58Scotoma (HP:0000575)2.38125009
59* Specific learning disability (HP:0001328)2.36265215
60Abnormality of the labia minora (HP:0012880)2.31657035
61* Broad foot (HP:0001769)2.30901263
62Absent rod-and cone-mediated responses on ERG (HP:0007688)2.30900612
63Broad-based gait (HP:0002136)2.27844491
64Narrow forehead (HP:0000341)2.27627846
65Abnormal hair whorl (HP:0010721)2.24075774
66Colon cancer (HP:0003003)2.20372765
67Pendular nystagmus (HP:0012043)2.20270679
68Drooling (HP:0002307)2.20212898
69Excessive salivation (HP:0003781)2.20212898
70Abnormality of the fovea (HP:0000493)2.20135999
71Decreased central vision (HP:0007663)2.19938863
72Oculomotor apraxia (HP:0000657)2.19560672
73Congenital hepatic fibrosis (HP:0002612)2.19486886
74Hypothermia (HP:0002045)2.18536977
75Bile duct proliferation (HP:0001408)2.18383203
76Abnormal biliary tract physiology (HP:0012439)2.18383203
77Methylmalonic acidemia (HP:0002912)2.16538070
78Abnormality of the corticospinal tract (HP:0002492)2.16318941
79True hermaphroditism (HP:0010459)2.14203498
80Inability to walk (HP:0002540)2.13975751
81* Aplasia/Hypoplasia of the lens (HP:0008063)2.12368328
82Attenuation of retinal blood vessels (HP:0007843)2.12244361
83Failure to thrive in infancy (HP:0001531)2.08190093
84* Decreased testicular size (HP:0008734)2.07615098
85Male pseudohermaphroditism (HP:0000037)2.06296715
86Hepatoblastoma (HP:0002884)2.06045611
87Generalized hypotonia (HP:0001290)2.05828269
88Hyperglycinuria (HP:0003108)2.05649620
89Abnormality of serine family amino acid metabolism (HP:0010894)2.05487181
90Abnormality of glycine metabolism (HP:0010895)2.05487181
91Dysdiadochokinesis (HP:0002075)2.05168856
92Mitochondrial inheritance (HP:0001427)2.05030292
93Rib fusion (HP:0000902)2.03826273
94Increased CSF lactate (HP:0002490)2.02919621
95Increased serum pyruvate (HP:0003542)2.01440226
96Abnormality of glycolysis (HP:0004366)2.01440226
97Truncal ataxia (HP:0002078)2.00933224
98Absent speech (HP:0001344)2.00350986
99Gaze-evoked nystagmus (HP:0000640)1.98297186
100* Postaxial hand polydactyly (HP:0001162)1.98148080
101* Retinitis pigmentosa (HP:0000510)1.96865549
102Hemiparesis (HP:0001269)1.96307334
103Acute necrotizing encephalopathy (HP:0006965)1.96156197
104Septo-optic dysplasia (HP:0100842)1.95865740
105Abnormality of the renal cortex (HP:0011035)1.95144451
106Sensory axonal neuropathy (HP:0003390)1.93773899
107Labial hypoplasia (HP:0000066)1.92308458
108* Prominent nasal bridge (HP:0000426)1.92019839
109* Multicystic kidney dysplasia (HP:0000003)1.91534329
110Aplasia/Hypoplasia of the uvula (HP:0010293)1.90027567
111Abnormal mitochondria in muscle tissue (HP:0008316)1.89960506
112Dandy-Walker malformation (HP:0001305)1.89940282
113Intestinal atresia (HP:0011100)1.89708833
114Optic disc pallor (HP:0000543)1.89479871
115Type II lissencephaly (HP:0007260)1.88912863
116Generalized myoclonic seizures (HP:0002123)1.87797199
117Increased hepatocellular lipid droplets (HP:0006565)1.87669601
118Type II diabetes mellitus (HP:0005978)1.86978208
119Hypoplastic female external genitalia (HP:0012815)1.84874959
120Supernumerary spleens (HP:0009799)1.84089478
121Protruding tongue (HP:0010808)1.84061243
122Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.83452069
123* Astigmatism (HP:0000483)1.83209100
124Optic nerve hypoplasia (HP:0000609)1.82618369
125Impaired vibration sensation in the lower limbs (HP:0002166)1.80583721
126Epileptiform EEG discharges (HP:0011182)1.80486680
127Anophthalmia (HP:0000528)1.80096976
128Oligodactyly (hands) (HP:0001180)1.79716455
129Lipid accumulation in hepatocytes (HP:0006561)1.79591714
130Gonadotropin excess (HP:0000837)1.78814975
131Furrowed tongue (HP:0000221)1.78498448
132Hypoplastic pelvis (HP:0008839)1.78278948
133Papillary thyroid carcinoma (HP:0002895)1.78223871
134Bronchiectasis (HP:0002110)1.78169691
135Median cleft lip (HP:0000161)1.77949420
136Reticulocytopenia (HP:0001896)1.76822116
137Tubular atrophy (HP:0000092)1.76085604
138Chorioretinal coloboma (HP:0000567)1.76028223
139Abnormality of the ileum (HP:0001549)1.75151234
140* Micropenis (HP:0000054)1.74215959
141Abnormality of chromosome stability (HP:0003220)1.73964258
142Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.73294139
143Degeneration of the lateral corticospinal tracts (HP:0002314)1.73294139
144Scrotal hypoplasia (HP:0000046)1.73197773
145Cerebral edema (HP:0002181)1.73174007
146Meckel diverticulum (HP:0002245)1.73046232
147Hypochromic microcytic anemia (HP:0004840)1.72921050
148Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72777614
149Progressive macrocephaly (HP:0004481)1.72596008
150Sloping forehead (HP:0000340)1.72445969
151Abnormal eating behavior (HP:0100738)1.71942344
152Methylmalonic aciduria (HP:0012120)1.70490981
153Abnormality of serum amino acid levels (HP:0003112)1.69151487
154Amyotrophic lateral sclerosis (HP:0007354)1.69148676
155Photophobia (HP:0000613)1.69006822
156Volvulus (HP:0002580)1.68829252
157Hepatocellular necrosis (HP:0001404)1.68088295
158EEG with generalized epileptiform discharges (HP:0011198)1.67774255
159Polyphagia (HP:0002591)1.67441015
160Abnormal lung lobation (HP:0002101)1.67395151
161* Aganglionic megacolon (HP:0002251)1.65078229
162Pancreatic cysts (HP:0001737)1.64918944
163Dysmetria (HP:0001310)1.63183887
164Chronic bronchitis (HP:0004469)1.62340451
165Depression (HP:0000716)1.62321314
166Thyroid carcinoma (HP:0002890)1.60136538

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.03197919
2GRK53.53862175
3NTRK33.31501995
4MAP3K43.18546503
5MAP2K73.04416740
6EPHA42.87557092
7MAP3K122.56198008
8STK162.40137420
9MAP2K42.30056550
10TRIM282.28048723
11MAP3K92.15045941
12MARK12.11593156
13AKT32.10698375
14ADRBK22.10277782
15ZAK2.08100976
16CDK122.05807366
17BMPR1B2.05326050
18BRSK22.04940176
19BMPR22.04915767
20GRK71.93619515
21PLK21.93595098
22MAP4K21.89250370
23NTRK21.88787595
24GRK11.86858435
25PNCK1.85498804
26MINK11.71820416
27NTRK11.66304428
28BCKDK1.63914287
29CDK191.61005520
30GRK61.58005498
31PRPF4B1.54483562
32NUAK11.54339421
33BUB11.52378057
34FRK1.47562115
35EPHB21.40329933
36CDC71.40131933
37DAPK21.38579099
38MAPK131.38314117
39CCNB11.37112944
40MKNK11.35595302
41PBK1.32153614
42MAPK151.30354410
43WEE11.28271425
44TYRO31.25638281
45MOS1.25412730
46ADRBK11.18622859
47SRPK11.16098980
48DYRK31.14973230
49CSNK1G11.14641384
50PRKCG1.14386104
51DAPK11.13886915
52PLK11.13514099
53PAK61.12602603
54MAPK71.12066774
55OXSR11.11348565
56TNIK1.10416149
57ARAF1.09904832
58CSNK1G31.01564614
59CAMK2A1.00103055
60PRKD30.98828632
61CDK50.97790403
62SGK4940.96952244
63SGK2230.96952244
64BRAF0.96704874
65PLK40.96124311
66EPHA30.94657718
67RIPK40.94244042
68NEK10.93173309
69LATS20.89735793
70VRK10.89112471
71CSNK1A1L0.87592007
72WNK10.87509291
73INSRR0.85354320
74STK380.85269229
75DYRK1A0.83207361
76WNK40.82603669
77SGK20.82545604
78SIK30.81935868
79BRSK10.80902847
80NME10.78948304
81ERBB30.78854248
82MAP3K60.77421567
83KSR10.76579262
84LIMK10.75472502
85STK38L0.75088333
86EIF2AK10.73457994
87CAMK2B0.72752871
88CDK180.72447036
89CDK30.72110099
90PASK0.71248566
91ATR0.69367825
92TSSK60.69207421
93TTK0.68284729
94PDK20.67196376
95CDK150.67022002
96EIF2AK30.67005050
97CAMKK20.64802552
98MARK20.64681758
99FGFR20.64330759
100ATM0.63012079
101CDK140.62724528
102CAMK40.61464218
103PKN10.60754685
104KSR20.59212225
105PDK40.56153635
106PDK30.56153635
107CDK11A0.56151815
108CSNK1G20.55583242
109PRKCI0.54946557
110OBSCN0.54492998
111VRK20.53687608
112PRKCE0.53612182
113PTK2B0.53505826
114SIK20.53020804
115CAMK1G0.52474600
116PHKG20.52182288
117PHKG10.52182288
118TGFBR10.51663580
119FES0.51147656
120CHEK10.50656657
121PAK30.50081767
122ERBB40.49983862
123MUSK0.49635805
124CAMK2D0.48844341
125BCR0.48732863
126WNK30.48621374
127PLK30.47883586
128PRKACA0.47580361
129PRKDC0.47183574
130CAMK10.45316384
131UHMK10.44449125
132CSNK1A10.44157745
133RPS6KA40.43973819
134MST40.43900459
135MATK0.43791899
136NEK60.43668883
137CHEK20.43611178
138STK390.43417954
139DYRK20.43324711
140PRKACB0.43261128
141CSNK1E0.41984045
142YES10.41685035
143ACVR1B0.41665814
144CDK80.41611877
145MAPKAPK50.41573639
146MKNK20.41553265
147PINK10.40470329
148HIPK20.40127096
149DYRK1B0.39861176
150AURKB0.39641607
151TNK20.38580977
152FGR0.37456014
153MAPK100.36953161
154MAP3K20.36876890
155SGK10.35545336

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.63973261
2Nicotine addiction_Homo sapiens_hsa050333.96570284
3Synaptic vesicle cycle_Homo sapiens_hsa047213.81267423
4Olfactory transduction_Homo sapiens_hsa047402.91318401
5GABAergic synapse_Homo sapiens_hsa047272.85893640
6Protein export_Homo sapiens_hsa030602.78999337
7Collecting duct acid secretion_Homo sapiens_hsa049662.75744339
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.73553186
9Propanoate metabolism_Homo sapiens_hsa006402.52111090
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.44843518
11Morphine addiction_Homo sapiens_hsa050322.40078391
12Taste transduction_Homo sapiens_hsa047422.33549278
13Glutamatergic synapse_Homo sapiens_hsa047242.33325665
14Circadian entrainment_Homo sapiens_hsa047132.24119585
15Steroid biosynthesis_Homo sapiens_hsa001002.20982133
16Serotonergic synapse_Homo sapiens_hsa047262.17210305
17Amphetamine addiction_Homo sapiens_hsa050312.13460712
18Dopaminergic synapse_Homo sapiens_hsa047282.08340076
19Long-term potentiation_Homo sapiens_hsa047202.07126354
20Homologous recombination_Homo sapiens_hsa034402.05089867
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.04560890
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.02931410
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.92455602
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.91710524
25Basal transcription factors_Homo sapiens_hsa030221.87743808
26Fanconi anemia pathway_Homo sapiens_hsa034601.87682389
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.86161552
28Oxidative phosphorylation_Homo sapiens_hsa001901.84995804
29Mismatch repair_Homo sapiens_hsa034301.83194688
30Butanoate metabolism_Homo sapiens_hsa006501.82772441
31RNA polymerase_Homo sapiens_hsa030201.79689550
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.77313976
33Vitamin B6 metabolism_Homo sapiens_hsa007501.75508251
34Fatty acid elongation_Homo sapiens_hsa000621.73942368
35Proteasome_Homo sapiens_hsa030501.72375089
36Insulin secretion_Homo sapiens_hsa049111.71189920
37Non-homologous end-joining_Homo sapiens_hsa034501.65738781
38Vibrio cholerae infection_Homo sapiens_hsa051101.65708982
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.60071299
40Long-term depression_Homo sapiens_hsa047301.60053761
41Salivary secretion_Homo sapiens_hsa049701.56988142
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.55431370
43Cholinergic synapse_Homo sapiens_hsa047251.51708365
44Cocaine addiction_Homo sapiens_hsa050301.51253576
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44214446
46RNA degradation_Homo sapiens_hsa030181.43735708
47Nucleotide excision repair_Homo sapiens_hsa034201.42941672
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.41031971
49Renin secretion_Homo sapiens_hsa049241.40836035
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.39548494
51Ribosome_Homo sapiens_hsa030101.38845700
52Calcium signaling pathway_Homo sapiens_hsa040201.37352528
53Peroxisome_Homo sapiens_hsa041461.28118031
54DNA replication_Homo sapiens_hsa030301.26795354
55Oxytocin signaling pathway_Homo sapiens_hsa049211.26512072
56Parkinsons disease_Homo sapiens_hsa050121.25763110
57Selenocompound metabolism_Homo sapiens_hsa004501.22437817
58Alzheimers disease_Homo sapiens_hsa050101.21900230
59GnRH signaling pathway_Homo sapiens_hsa049121.20583458
60Primary bile acid biosynthesis_Homo sapiens_hsa001201.20409944
61Cardiac muscle contraction_Homo sapiens_hsa042601.19875523
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19821216
63Base excision repair_Homo sapiens_hsa034101.19446076
64RNA transport_Homo sapiens_hsa030131.18858038
65Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15986166
66Gastric acid secretion_Homo sapiens_hsa049711.14464112
67Aldosterone synthesis and secretion_Homo sapiens_hsa049251.13514582
68Fatty acid metabolism_Homo sapiens_hsa012121.12980395
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.12583148
70One carbon pool by folate_Homo sapiens_hsa006701.10282953
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10173255
72Huntingtons disease_Homo sapiens_hsa050161.08945806
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07457067
74Cysteine and methionine metabolism_Homo sapiens_hsa002701.07244266
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.06504489
76Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02484880
77cAMP signaling pathway_Homo sapiens_hsa040240.98339053
78Gap junction_Homo sapiens_hsa045400.97586228
79beta-Alanine metabolism_Homo sapiens_hsa004100.96646513
80Circadian rhythm_Homo sapiens_hsa047100.94843600
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93050066
82Spliceosome_Homo sapiens_hsa030400.92740513
83Glutathione metabolism_Homo sapiens_hsa004800.91801992
84Chemical carcinogenesis_Homo sapiens_hsa052040.91024988
85Basal cell carcinoma_Homo sapiens_hsa052170.89581050
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89330362
87Tryptophan metabolism_Homo sapiens_hsa003800.89307408
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87332453
89Fructose and mannose metabolism_Homo sapiens_hsa000510.86518160
90Nitrogen metabolism_Homo sapiens_hsa009100.84613538
91Carbon metabolism_Homo sapiens_hsa012000.83012925
92Ovarian steroidogenesis_Homo sapiens_hsa049130.81837579
93Metabolic pathways_Homo sapiens_hsa011000.79865970
94Purine metabolism_Homo sapiens_hsa002300.79667669
95Oocyte meiosis_Homo sapiens_hsa041140.79532359
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.79108088
97Pyrimidine metabolism_Homo sapiens_hsa002400.78812744
98Regulation of autophagy_Homo sapiens_hsa041400.78452619
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.78160391
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77802697
101Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75836069
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75498951
103Fatty acid degradation_Homo sapiens_hsa000710.74428802
104Axon guidance_Homo sapiens_hsa043600.73167318
105Folate biosynthesis_Homo sapiens_hsa007900.70594257
106ErbB signaling pathway_Homo sapiens_hsa040120.69443680
107Estrogen signaling pathway_Homo sapiens_hsa049150.69419350
108Inositol phosphate metabolism_Homo sapiens_hsa005620.69108287
109Melanogenesis_Homo sapiens_hsa049160.67462517
110Retinol metabolism_Homo sapiens_hsa008300.67280726
111Sulfur relay system_Homo sapiens_hsa041220.66773199
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65842540
113Arginine and proline metabolism_Homo sapiens_hsa003300.65505380
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64702226
115Biosynthesis of amino acids_Homo sapiens_hsa012300.62831991
116Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62398510
117Ether lipid metabolism_Homo sapiens_hsa005650.61831017
118Rheumatoid arthritis_Homo sapiens_hsa053230.61352842
119Choline metabolism in cancer_Homo sapiens_hsa052310.61282205
120Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61065771
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.59913675
122MAPK signaling pathway_Homo sapiens_hsa040100.55812359
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55554701
124mRNA surveillance pathway_Homo sapiens_hsa030150.55415180
125Cell cycle_Homo sapiens_hsa041100.54542644
126Ras signaling pathway_Homo sapiens_hsa040140.53524631
127Alcoholism_Homo sapiens_hsa050340.52298296
128SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51921513
129Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50367271
130Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49185327
131Lysine degradation_Homo sapiens_hsa003100.49102908
132Steroid hormone biosynthesis_Homo sapiens_hsa001400.48847808
133Caffeine metabolism_Homo sapiens_hsa002320.47215179
134mTOR signaling pathway_Homo sapiens_hsa041500.46900542
135Type II diabetes mellitus_Homo sapiens_hsa049300.46705127
136Glioma_Homo sapiens_hsa052140.46214727
137Dorso-ventral axis formation_Homo sapiens_hsa043200.43350010
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.42552906
139Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41447735
140Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40870042
141Hippo signaling pathway_Homo sapiens_hsa043900.40013859
142Tyrosine metabolism_Homo sapiens_hsa003500.39508394
143Wnt signaling pathway_Homo sapiens_hsa043100.38904234
144Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38679936
145Dilated cardiomyopathy_Homo sapiens_hsa054140.38673779
146Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.37563516
147African trypanosomiasis_Homo sapiens_hsa051430.35003187
148Pancreatic secretion_Homo sapiens_hsa049720.33847139
149Glucagon signaling pathway_Homo sapiens_hsa049220.33142212
150Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32851550
151Type I diabetes mellitus_Homo sapiens_hsa049400.32584292
152Linoleic acid metabolism_Homo sapiens_hsa005910.31596024
153Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31341376
154Thyroid hormone synthesis_Homo sapiens_hsa049180.31111008
155Rap1 signaling pathway_Homo sapiens_hsa040150.30648757
156Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29330909
157Phagosome_Homo sapiens_hsa041450.28245341
158alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26389989
159Hedgehog signaling pathway_Homo sapiens_hsa043400.26245033
160Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.25045876
161Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.22702837
162Arachidonic acid metabolism_Homo sapiens_hsa005900.22195150
163Sphingolipid signaling pathway_Homo sapiens_hsa040710.21481978
164Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.20624529
165Pyruvate metabolism_Homo sapiens_hsa006200.20586693
166Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.20311006
167Galactose metabolism_Homo sapiens_hsa000520.19876906

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »