BBS5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that has been directly linked to Bardet-Biedl syndrome. The primary features of this syndrome include retinal dystrophy, obesity, polydactyly, renal abnormalities and learning disabilities. Experimentation in non-human eukaryotes suggests that this gene is expressed in ciliated cells and that it is required for the formation of cilia. Alternate transcriptional splice variants have been observed but have not been fully characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule metabolic process (GO:0044036)6.79236338
2cell wall macromolecule catabolic process (GO:0016998)6.79236338
3cilium or flagellum-dependent cell motility (GO:0001539)6.43928798
4fusion of sperm to egg plasma membrane (GO:0007342)5.84653618
5axonemal dynein complex assembly (GO:0070286)5.60381859
6multicellular organism reproduction (GO:0032504)5.35135331
7epithelial cilium movement (GO:0003351)5.31218174
8cilium movement (GO:0003341)5.09460015
9plasma membrane fusion (GO:0045026)4.60633004
10acrosome reaction (GO:0007340)4.28720898
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.28396475
12protein localization to cilium (GO:0061512)4.21187933
13behavioral response to nicotine (GO:0035095)4.14339741
14acrosome assembly (GO:0001675)4.13470322
15microtubule depolymerization (GO:0007019)4.05391611
16sperm-egg recognition (GO:0035036)4.04072851
17intraciliary transport (GO:0042073)4.02474709
18reproduction (GO:0000003)3.92277652
19neuron cell-cell adhesion (GO:0007158)3.86019309
20* motile cilium assembly (GO:0044458)3.75267033
21axoneme assembly (GO:0035082)3.73788683
22sperm motility (GO:0030317)3.70392435
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.65724641
24regulation of rhodopsin mediated signaling pathway (GO:0022400)3.65115644
25GTP biosynthetic process (GO:0006183)3.60687015
26nonmotile primary cilium assembly (GO:0035058)3.55368687
27ventricular system development (GO:0021591)3.54420886
28regulation of cilium movement (GO:0003352)3.53534456
29cell-cell recognition (GO:0009988)3.50364661
30left/right pattern formation (GO:0060972)3.49495101
31rhodopsin mediated signaling pathway (GO:0016056)3.45862364
32single fertilization (GO:0007338)3.44297085
33presynaptic membrane assembly (GO:0097105)3.41456811
34microtubule polymerization or depolymerization (GO:0031109)3.37639709
35establishment of protein localization to mitochondrial membrane (GO:0090151)3.37322654
36centriole assembly (GO:0098534)3.36009625
37centriole replication (GO:0007099)3.27984298
38startle response (GO:0001964)3.27381042
39chaperone-mediated protein transport (GO:0072321)3.25369339
40* cilium assembly (GO:0042384)3.22590802
41spermatid nucleus differentiation (GO:0007289)3.20751804
42spermatid development (GO:0007286)3.20343324
43* cilium organization (GO:0044782)3.18843688
44piRNA metabolic process (GO:0034587)3.18781818
45male meiosis (GO:0007140)3.15586877
46calcium ion-dependent exocytosis (GO:0017156)3.15439453
47regulation of short-term neuronal synaptic plasticity (GO:0048172)3.13991050
48binding of sperm to zona pellucida (GO:0007339)3.13507991
49photoreceptor cell maintenance (GO:0045494)3.13021190
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.10558650
51presynaptic membrane organization (GO:0097090)3.09710005
52mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.08460961
53nucleoside diphosphate phosphorylation (GO:0006165)3.06477818
54long-chain fatty acid biosynthetic process (GO:0042759)3.04708508
55guanosine-containing compound biosynthetic process (GO:1901070)3.02828864
56protein neddylation (GO:0045116)3.02788404
57positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.01529410
58cilium morphogenesis (GO:0060271)3.00987435
59dendritic spine morphogenesis (GO:0060997)2.97964717
60transmission of nerve impulse (GO:0019226)2.92974370
61protein localization to synapse (GO:0035418)2.87959076
62ATP synthesis coupled proton transport (GO:0015986)2.85899654
63energy coupled proton transport, down electrochemical gradient (GO:0015985)2.85899654
64urinary tract smooth muscle contraction (GO:0014848)2.83686504
65photoreceptor cell development (GO:0042461)2.83436377
66response to pheromone (GO:0019236)2.83334297
67left/right axis specification (GO:0070986)2.81954330
68pattern specification involved in kidney development (GO:0061004)2.81437834
69axon ensheathment in central nervous system (GO:0032291)2.80172550
70central nervous system myelination (GO:0022010)2.80172550
71eye photoreceptor cell development (GO:0042462)2.80160377
72UTP biosynthetic process (GO:0006228)2.80020927
73mitochondrial respiratory chain complex I assembly (GO:0032981)2.77190999
74NADH dehydrogenase complex assembly (GO:0010257)2.77190999
75mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.77190999
76positive regulation of synapse assembly (GO:0051965)2.75433044
77regulation of feeding behavior (GO:0060259)2.74655407
78microtubule bundle formation (GO:0001578)2.71409907
79glutamate receptor signaling pathway (GO:0007215)2.70710688
80cell recognition (GO:0008037)2.69859351
81GMP metabolic process (GO:0046037)2.68804767
82protein complex biogenesis (GO:0070271)2.68303169
83positive regulation of action potential (GO:0045760)2.67350137
84vocalization behavior (GO:0071625)2.67076412
85membrane depolarization during action potential (GO:0086010)2.66823006
86positive regulation of CREB transcription factor activity (GO:0032793)2.66277528
87keratinocyte development (GO:0003334)2.65429209
88respiratory electron transport chain (GO:0022904)2.64800901
89regulation of respiratory system process (GO:0044065)2.64652574
90ionotropic glutamate receptor signaling pathway (GO:0035235)2.64581694
91synaptic vesicle docking involved in exocytosis (GO:0016081)2.63863715
92deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.61884370
93G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.61501920
94electron transport chain (GO:0022900)2.60958095
95melanin biosynthetic process (GO:0042438)2.60619925
96detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.60521261
97retinal rod cell development (GO:0046548)2.60150491
98neuron recognition (GO:0008038)2.59082889
99ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.58667349
100alanine transport (GO:0032328)2.57929472
101* cellular component assembly involved in morphogenesis (GO:0010927)2.57776622
102cornea development in camera-type eye (GO:0061303)2.57407708
103limb development (GO:0060173)2.57198599
104appendage development (GO:0048736)2.57198599
105regulation of glutamate secretion (GO:0014048)2.56900436
106DNA methylation involved in gamete generation (GO:0043046)2.56438045
107regulation of hippo signaling (GO:0035330)2.54902860
108negative regulation of synaptic transmission, GABAergic (GO:0032229)2.51442535
109gamma-aminobutyric acid signaling pathway (GO:0007214)2.51278121
110regulation of meiosis I (GO:0060631)2.51252916
111response to redox state (GO:0051775)2.49026193
112dendrite development (GO:0016358)2.48996236
113proline transport (GO:0015824)2.48652696
114neuron-neuron synaptic transmission (GO:0007270)2.48635822
115fertilization (GO:0009566)2.48591866
116positive regulation of meiotic cell cycle (GO:0051446)2.48509521
117single strand break repair (GO:0000012)2.47680490
118mitochondrial respiratory chain complex assembly (GO:0033108)2.46424509
119retinal cone cell development (GO:0046549)2.45984268
120regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.45829360
121cardiovascular system development (GO:0072358)2.45315003
122regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.43523360
123secondary metabolite biosynthetic process (GO:0044550)2.43157800
124microtubule severing (GO:0051013)2.42158137
125membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.40637505
126axonal fasciculation (GO:0007413)2.39877350
127snRNA transcription (GO:0009301)2.38667299
128endosome to melanosome transport (GO:0035646)2.38521073
129endosome to pigment granule transport (GO:0043485)2.38521073
130cellular response to ATP (GO:0071318)2.37890264
131regulation of microtubule-based movement (GO:0060632)2.35318085
132melanin metabolic process (GO:0006582)2.33540591
133tryptophan catabolic process (GO:0006569)2.32607419
134indole-containing compound catabolic process (GO:0042436)2.32607419
135indolalkylamine catabolic process (GO:0046218)2.32607419
136lung epithelium development (GO:0060428)2.32537895
137detection of light stimulus involved in visual perception (GO:0050908)2.30403553
138detection of light stimulus involved in sensory perception (GO:0050962)2.30403553
139protein polyglutamylation (GO:0018095)2.30043543
140negative regulation of axon extension involved in axon guidance (GO:0048843)2.29547001
141positive regulation of fatty acid oxidation (GO:0046321)2.28679079
142indolalkylamine metabolic process (GO:0006586)2.27400241
143melanocyte differentiation (GO:0030318)2.24877612
144parturition (GO:0007567)2.24371131
145positive regulation of protein kinase C signaling (GO:0090037)2.23671368
146pigment cell differentiation (GO:0050931)2.23624802
147kynurenine metabolic process (GO:0070189)2.23094741
148nephron epithelium morphogenesis (GO:0072088)2.22438130
149nephron tubule morphogenesis (GO:0072078)2.22438130
150spinal cord motor neuron differentiation (GO:0021522)2.20343535
151fucose catabolic process (GO:0019317)2.20327272
152L-fucose metabolic process (GO:0042354)2.20327272
153L-fucose catabolic process (GO:0042355)2.20327272
154adult walking behavior (GO:0007628)2.18728081
155negative regulation of protein localization to cell surface (GO:2000009)2.18689745
156negative regulation of axon guidance (GO:1902668)2.18590877
157gamma-aminobutyric acid transport (GO:0015812)2.17114146
158smoothened signaling pathway (GO:0007224)2.15732086
159negative regulation of mast cell activation (GO:0033004)2.15120535
160negative regulation of sodium ion transport (GO:0010766)2.14981491
161synaptic transmission, glutamatergic (GO:0035249)2.14739254
162postsynaptic membrane organization (GO:0001941)2.14088776
163intestinal cholesterol absorption (GO:0030299)2.12485911
164regulation of neurotransmitter uptake (GO:0051580)2.10929092
165camera-type eye morphogenesis (GO:0048593)2.10149888
166regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.09834543
167regulation of axon extension involved in axon guidance (GO:0048841)2.09611752
168auditory behavior (GO:0031223)2.09507190
169oxidative demethylation (GO:0070989)2.09428555
170regulation of respiratory gaseous exchange (GO:0043576)2.08955895
171establishment of protein localization to Golgi (GO:0072600)2.08444737
172positive regulation of fatty acid transport (GO:2000193)2.07749044
173endocardial cushion development (GO:0003197)2.07207781

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.45683539
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.23720051
3GBX2_23144817_ChIP-Seq_PC3_Human3.18190553
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.90307620
5VDR_22108803_ChIP-Seq_LS180_Human2.87215665
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.83207086
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.81953224
8DROSHA_22980978_ChIP-Seq_HELA_Human2.73585612
9TAF15_26573619_Chip-Seq_HEK293_Human2.65728094
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.38045032
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.37509772
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.37278416
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.37136692
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.36903343
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.23184348
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.21200371
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.21089841
18BMI1_23680149_ChIP-Seq_NPCS_Mouse2.19650407
19FUS_26573619_Chip-Seq_HEK293_Human2.02966602
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97959938
21P300_19829295_ChIP-Seq_ESCs_Human1.84972421
22RNF2_27304074_Chip-Seq_NSC_Mouse1.83042152
23SUZ12_27294783_Chip-Seq_NPCs_Mouse1.80327029
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.76627621
25TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.74850117
26ZNF274_21170338_ChIP-Seq_K562_Hela1.73463444
27EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.73009034
28PCGF2_27294783_Chip-Seq_NPCs_Mouse1.72384423
29NANOG_18555785_Chip-Seq_ESCs_Mouse1.71347046
30ER_23166858_ChIP-Seq_MCF-7_Human1.70413407
31CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.66513569
32MTF2_20144788_ChIP-Seq_MESCs_Mouse1.63954877
33NFE2_27457419_Chip-Seq_LIVER_Mouse1.63312209
34IGF1R_20145208_ChIP-Seq_DFB_Human1.62932328
35SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.62382842
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61708070
37REST_21632747_ChIP-Seq_MESCs_Mouse1.58166635
38JARID2_20064375_ChIP-Seq_MESCs_Mouse1.58050193
39P53_22387025_ChIP-Seq_ESCs_Mouse1.55910947
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.55650226
41TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54058982
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.53147012
43AHR_22903824_ChIP-Seq_MCF-7_Human1.51875933
44TAL1_26923725_Chip-Seq_HPCs_Mouse1.51815550
45SUZ12_18555785_Chip-Seq_ESCs_Mouse1.51791583
46EWS_26573619_Chip-Seq_HEK293_Human1.51602637
47* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.51112782
48E2F1_18555785_Chip-Seq_ESCs_Mouse1.50933999
49* SMAD4_21799915_ChIP-Seq_A2780_Human1.50223135
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50156429
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.49678559
52CMYC_18555785_Chip-Seq_ESCs_Mouse1.49107365
53SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.48798991
54CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47745113
55STAT3_18555785_Chip-Seq_ESCs_Mouse1.47636740
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46251031
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.45720996
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.44950808
59P300_18555785_Chip-Seq_ESCs_Mouse1.42926052
60SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.41938020
61SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.41365158
62PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39119866
63* SOX2_18555785_Chip-Seq_ESCs_Mouse1.38184519
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.36888467
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36542445
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36346609
67RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.35831339
68NMYC_18555785_Chip-Seq_ESCs_Mouse1.34452589
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34439264
70KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.33329774
71CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.33154013
72KLF4_18555785_Chip-Seq_ESCs_Mouse1.32805618
73* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.32713641
74MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.32143367
75OCT4_18555785_Chip-Seq_ESCs_Mouse1.30651664
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30166733
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29801710
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.29455502
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.29275301
80REST_18959480_ChIP-ChIP_MESCs_Mouse1.26910764
81IKZF1_21737484_ChIP-ChIP_HCT116_Human1.26177602
82KDM2B_26808549_Chip-Seq_REH_Human1.25460670
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25097555
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25097555
85NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.24431683
86ZFX_18555785_Chip-Seq_ESCs_Mouse1.24002199
87* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.23869190
88CRX_20693478_ChIP-Seq_RETINA_Mouse1.22852775
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22852352
90JARID2_20075857_ChIP-Seq_MESCs_Mouse1.22387123
91TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20757452
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19246541
93ESRRB_18555785_Chip-Seq_ESCs_Mouse1.18976150
94CTCF_27219007_Chip-Seq_Bcells_Human1.18856282
95SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.18826919
96EZH2_27294783_Chip-Seq_ESCs_Mouse1.17758950
97IRF1_19129219_ChIP-ChIP_H3396_Human1.17060033
98AR_21572438_ChIP-Seq_LNCaP_Human1.16989315
99KAP1_22055183_ChIP-Seq_ESCs_Mouse1.16405137
100SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.16298930
101PU1_27457419_Chip-Seq_LIVER_Mouse1.16155093
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14628683
103SUZ12_27294783_Chip-Seq_ESCs_Mouse1.14457490
104AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14262745
105RING1B_27294783_Chip-Seq_ESCs_Mouse1.13729751
106* CTCF_18555785_Chip-Seq_ESCs_Mouse1.13233109
107CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12752285
108BCAT_22108803_ChIP-Seq_LS180_Human1.12719407
109KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.11909848
110MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10885192
111ESR2_21235772_ChIP-Seq_MCF-7_Human1.10863870
112STAT3_23295773_ChIP-Seq_U87_Human1.10821116
113* RUNX2_22187159_ChIP-Seq_PCA_Human1.10004402
114CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09117691
115EZH2_18974828_ChIP-Seq_MESCs_Mouse1.09093432
116RNF2_18974828_ChIP-Seq_MESCs_Mouse1.09093432
117RNF2_27304074_Chip-Seq_ESCs_Mouse1.07414634
118PIAS1_25552417_ChIP-Seq_VCAP_Human1.06684368
119PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.06614286
120ERG_21242973_ChIP-ChIP_JURKAT_Human1.04065911
121SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03908003
122* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03397143
123ESR1_21235772_ChIP-Seq_MCF-7_Human1.02670680
124AR_19668381_ChIP-Seq_PC3_Human1.02609624
125TP53_16413492_ChIP-PET_HCT116_Human1.02551123
126NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01599894
127TP53_20018659_ChIP-ChIP_R1E_Mouse1.00068623
128TCF4_23295773_ChIP-Seq_U87_Human1.00051489
129RARB_27405468_Chip-Seq_BRAIN_Mouse0.99248161
130ERA_21632823_ChIP-Seq_H3396_Human0.99207113
131RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99205693
132SMC4_20622854_ChIP-Seq_HELA_Human0.99196460
133RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98538645
134AR_25329375_ChIP-Seq_VCAP_Human0.97292558
135ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97103135
136P68_20966046_ChIP-Seq_HELA_Human0.94258025
137TP63_22573176_ChIP-Seq_HFKS_Human0.93163536
138BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91569609
139PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.91205665
140RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90999814
141TP53_23651856_ChIP-Seq_MEFs_Mouse0.90648324
142TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89716754
143GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87800913
144SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86861532
145EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.86563694
146EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.86305735
147OCT4_19829295_ChIP-Seq_ESCs_Human0.85279832
148STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84150922
149RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.83742607
150RXR_22108803_ChIP-Seq_LS180_Human0.82612355
151ZNF217_24962896_ChIP-Seq_MCF-7_Human0.82039315
152VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.81947095
153WDR5_24793694_ChIP-Seq_LNCAP_Human0.81599290
154SMAD3_21741376_ChIP-Seq_ESCs_Human0.81483444
155SOX2_21211035_ChIP-Seq_LN229_Gbm0.80579245
156TDRD3_21172665_ChIP-Seq_MCF-7_Human0.80521143

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.99188113
2MP0005410_abnormal_fertilization3.38256468
3MP0001188_hyperpigmentation3.12143139
4MP0002102_abnormal_ear_morphology3.09720878
5MP0000569_abnormal_digit_pigmentation3.02022693
6MP0002653_abnormal_ependyma_morphology2.86508844
7MP0006292_abnormal_olfactory_placode2.85163445
8MP0001529_abnormal_vocalization2.62896548
9MP0003136_yellow_coat_color2.60039854
10MP0005551_abnormal_eye_electrophysiolog2.50054926
11MP0005423_abnormal_somatic_nervous2.39940905
12MP0006276_abnormal_autonomic_nervous2.38626215
13MP0009046_muscle_twitch2.32170317
14MP0001984_abnormal_olfaction2.30923515
15MP0004043_abnormal_pH_regulation2.23460697
16MP0009745_abnormal_behavioral_response2.11215559
17MP0001968_abnormal_touch/_nociception2.08241852
18MP0003635_abnormal_synaptic_transmissio2.02945464
19MP0008877_abnormal_DNA_methylation2.02387217
20MP0001486_abnormal_startle_reflex2.02166431
21MP0002572_abnormal_emotion/affect_behav2.01626820
22MP0002064_seizures2.00419569
23MP0002272_abnormal_nervous_system1.98074827
24MP0004142_abnormal_muscle_tone1.92502362
25MP0005409_darkened_coat_color1.91822509
26MP0002735_abnormal_chemical_nociception1.85332104
27MP0002736_abnormal_nociception_after1.83955978
28MP0001440_abnormal_grooming_behavior1.82484499
29MP0006072_abnormal_retinal_apoptosis1.82072698
30MP0001905_abnormal_dopamine_level1.81761540
31MP0002638_abnormal_pupillary_reflex1.81597547
32MP0002734_abnormal_mechanical_nocicepti1.81566357
33MP0005645_abnormal_hypothalamus_physiol1.78739152
34MP0002063_abnormal_learning/memory/cond1.78278456
35MP0004270_analgesia1.77857447
36MP0005379_endocrine/exocrine_gland_phen1.75374488
37MP0004885_abnormal_endolymph1.70005429
38MP0000778_abnormal_nervous_system1.67634851
39MP0003698_abnormal_male_reproductive1.66215606
40MP0005253_abnormal_eye_physiology1.64890056
41MP0005174_abnormal_tail_pigmentation1.63650788
42MP0004130_abnormal_muscle_cell1.61819581
43MP0005171_absent_coat_pigmentation1.59110803
44MP0004133_heterotaxia1.56524526
45MP0004859_abnormal_synaptic_plasticity1.56137202
46MP0001986_abnormal_taste_sensitivity1.54230823
47MP0005646_abnormal_pituitary_gland1.49465873
48MP0002163_abnormal_gland_morphology1.48127622
49MP0003787_abnormal_imprinting1.47485261
50MP0005377_hearing/vestibular/ear_phenot1.47131317
51MP0003878_abnormal_ear_physiology1.47131317
52MP0000566_synostosis1.43470441
53MP0008875_abnormal_xenobiotic_pharmacok1.42486183
54MP0001501_abnormal_sleep_pattern1.41972099
55MP0002557_abnormal_social/conspecific_i1.41891817
56MP0001929_abnormal_gametogenesis1.40990958
57MP0002184_abnormal_innervation1.40153527
58MP0002067_abnormal_sensory_capabilities1.38707745
59MP0005503_abnormal_tendon_morphology1.38056854
60MP0003646_muscle_fatigue1.37917911
61MP0000371_diluted_coat_color1.35983825
62MP0000026_abnormal_inner_ear1.35529090
63MP0003195_calcinosis1.35134819
64MP0004742_abnormal_vestibular_system1.34329031
65MP0009780_abnormal_chondrocyte_physiolo1.33707778
66MP0002837_dystrophic_cardiac_calcinosis1.32629544
67MP0008789_abnormal_olfactory_epithelium1.32394226
68MP0002752_abnormal_somatic_nervous1.30668221
69MP0001485_abnormal_pinna_reflex1.29290214
70MP0009379_abnormal_foot_pigmentation1.28570588
71MP0001963_abnormal_hearing_physiology1.26964716
72MP0001502_abnormal_circadian_rhythm1.26839307
73MP0010386_abnormal_urinary_bladder1.24483349
74MP0001970_abnormal_pain_threshold1.23707091
75MP0002909_abnormal_adrenal_gland1.22402549
76MP0005394_taste/olfaction_phenotype1.21723152
77MP0005499_abnormal_olfactory_system1.21723152
78MP0000383_abnormal_hair_follicle1.21451332
79MP0003950_abnormal_plasma_membrane1.21250055
80MP0003172_abnormal_lysosome_physiology1.20587233
81MP0003045_fibrosis1.20396458
82MP0004381_abnormal_hair_follicle1.17444330
83MP0001324_abnormal_eye_pigmentation1.15584712
84MP0002095_abnormal_skin_pigmentation1.15074819
85MP0002882_abnormal_neuron_morphology1.14603419
86MP0000427_abnormal_hair_cycle1.14427627
87MP0005386_behavior/neurological_phenoty1.14084272
88MP0004924_abnormal_behavior1.14084272
89MP0002277_abnormal_respiratory_mucosa1.13632389
90MP0000631_abnormal_neuroendocrine_gland1.13575814
91MP0002876_abnormal_thyroid_physiology1.13492803
92MP0002210_abnormal_sex_determination1.09104949
93MP0008058_abnormal_DNA_repair1.08809355
94MP0003011_delayed_dark_adaptation1.08380415
95MP0003122_maternal_imprinting1.07764342
96MP0003718_maternal_effect1.05606953
97MP0005248_abnormal_Harderian_gland1.05143833
98MP0002928_abnormal_bile_duct1.03004847
99MP0002938_white_spotting1.01773191
100MP0003938_abnormal_ear_development1.01505497
101MP0005448_abnormal_energy_balance1.01417173
102MP0005195_abnormal_posterior_eye1.01109788
103MP0002229_neurodegeneration0.99682492
104MP0002733_abnormal_thermal_nociception0.97770634
105MP0003941_abnormal_skin_development0.97091646
106MP0008872_abnormal_physiological_respon0.95460511
107MP0002168_other_aberrant_phenotype0.94973760
108MP0000372_irregular_coat_pigmentation0.94749483
109MP0001664_abnormal_digestion0.93282078
110MP0003283_abnormal_digestive_organ0.92825564
111MP0002249_abnormal_larynx_morphology0.92383472
112MP0008057_abnormal_DNA_replication0.92363153
113MP0004145_abnormal_muscle_electrophysio0.92138771
114MP0004858_abnormal_nervous_system0.90768712
115MP0008995_early_reproductive_senescence0.90728527
116MP0009384_cardiac_valve_regurgitation0.90167540
117MP0003633_abnormal_nervous_system0.89456213
118MP0002138_abnormal_hepatobiliary_system0.86860482
119MP0002075_abnormal_coat/hair_pigmentati0.86143241
120MP0002066_abnormal_motor_capabilities/c0.84796931
121MP0000653_abnormal_sex_gland0.82795664
122MP0008961_abnormal_basal_metabolism0.81683320
123MP0003631_nervous_system_phenotype0.80507541
124MP0000230_abnormal_systemic_arterial0.80264252
125MP0002161_abnormal_fertility/fecundity0.80226513
126MP0001270_distended_abdomen0.79997447
127MP0001145_abnormal_male_reproductive0.78473668
128MP0005408_hypopigmentation0.78031677
129MP0003879_abnormal_hair_cell0.76643141
130MP0000049_abnormal_middle_ear0.76435275
131MP0002160_abnormal_reproductive_system0.74773727
132MP0002152_abnormal_brain_morphology0.74266151
133MP0006035_abnormal_mitochondrial_morpho0.74136820
134MP0000955_abnormal_spinal_cord0.74026515
135MP0000015_abnormal_ear_pigmentation0.73460077
136MP0005391_vision/eye_phenotype0.72686597
137MP0008260_abnormal_autophagy0.71611464
138MP0003121_genomic_imprinting0.71594370
139MP0003315_abnormal_perineum_morphology0.71148953
140MP0005451_abnormal_body_composition0.69936867
141MP0003786_premature_aging0.68825301
142MP0009697_abnormal_copulation0.67069555

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.96276512
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.30471504
3Absent/shortened dynein arms (HP:0200106)6.30471504
4Abnormal respiratory motile cilium physiology (HP:0012261)5.51716173
5Abnormal respiratory epithelium morphology (HP:0012253)5.50999082
6Abnormal respiratory motile cilium morphology (HP:0005938)5.50999082
7Abnormal ciliary motility (HP:0012262)5.38122171
8Rhinitis (HP:0012384)4.44097338
9* Medial flaring of the eyebrow (HP:0010747)4.00448581
10Cystic liver disease (HP:0006706)3.93449950
11* Gait imbalance (HP:0002141)3.76171294
12* Congenital primary aphakia (HP:0007707)3.65073737
13* Nephrogenic diabetes insipidus (HP:0009806)3.43807406
14Genetic anticipation (HP:0003743)3.17083302
15Pancreatic fibrosis (HP:0100732)3.16815312
16Molar tooth sign on MRI (HP:0002419)3.15719074
17Abnormality of midbrain morphology (HP:0002418)3.15719074
18Acute necrotizing encephalopathy (HP:0006965)3.14675041
19Chronic bronchitis (HP:0004469)3.10909599
20Congenital stationary night blindness (HP:0007642)3.05504437
21Tubular atrophy (HP:0000092)3.03712204
22Nephronophthisis (HP:0000090)2.99816887
23Polydipsia (HP:0001959)2.90064162
24Abnormal drinking behavior (HP:0030082)2.90064162
25* Vaginal atresia (HP:0000148)2.87012632
26True hermaphroditism (HP:0010459)2.86778001
27* Genital tract atresia (HP:0001827)2.85801680
28Focal motor seizures (HP:0011153)2.82360213
29Protruding tongue (HP:0010808)2.79749584
30Decreased circulating renin level (HP:0003351)2.71524654
31* Poor coordination (HP:0002370)2.70106185
32Progressive macrocephaly (HP:0004481)2.69280929
33Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.64613004
34* Aplasia/Hypoplasia of the lens (HP:0008063)2.64020875
35Clumsiness (HP:0002312)2.59214225
36Pancreatic cysts (HP:0001737)2.55296775
37Abnormal mitochondria in muscle tissue (HP:0008316)2.52758202
38Febrile seizures (HP:0002373)2.51016127
39Abnormality of the renal cortex (HP:0011035)2.47915279
40Mitochondrial inheritance (HP:0001427)2.44150742
41Atonic seizures (HP:0010819)2.42544814
42Occipital encephalocele (HP:0002085)2.42224300
43Optic disc pallor (HP:0000543)2.41565501
44Decreased central vision (HP:0007663)2.36274630
45Abnormality of the renal medulla (HP:0100957)2.35858859
46Large for gestational age (HP:0001520)2.33820192
47Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.33141278
48Abnormal rod and cone electroretinograms (HP:0008323)2.31474971
49Retinal dysplasia (HP:0007973)2.29175168
50Hypoplastic ischia (HP:0003175)2.27354587
51Abnormal hair whorl (HP:0010721)2.26992203
52Acute encephalopathy (HP:0006846)2.26984442
53Nasal polyposis (HP:0100582)2.25978254
54Epileptic encephalopathy (HP:0200134)2.25796750
55Anencephaly (HP:0002323)2.23710463
56Sclerocornea (HP:0000647)2.22574014
57Bony spicule pigmentary retinopathy (HP:0007737)2.22107678
58Focal seizures (HP:0007359)2.19448927
59Absent rod-and cone-mediated responses on ERG (HP:0007688)2.17765994
60Increased neuronal autofluorescent lipopigment (HP:0002074)2.16528873
61Optic nerve hypoplasia (HP:0000609)2.16295667
62Attenuation of retinal blood vessels (HP:0007843)2.15187567
63Median cleft lip (HP:0000161)2.11144956
64Hyperventilation (HP:0002883)2.10713780
65Bronchiectasis (HP:0002110)2.10445830
66Abnormality of macular pigmentation (HP:0008002)2.05832952
67Furrowed tongue (HP:0000221)2.05542546
68Obstructive sleep apnea (HP:0002870)1.99686780
69Parakeratosis (HP:0001036)1.99190720
70Chronic hepatic failure (HP:0100626)1.98231451
71Abnormality of the nasal mucosa (HP:0000433)1.98086524
72Polyuria (HP:0000103)1.98068193
73Congenital sensorineural hearing impairment (HP:0008527)1.96171800
74Renal Fanconi syndrome (HP:0001994)1.96104699
75Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.94980888
76Broad-based gait (HP:0002136)1.94826184
77Abnormality of renal resorption (HP:0011038)1.94676714
78Hypothermia (HP:0002045)1.94272792
79Increased CSF lactate (HP:0002490)1.94051286
80Aplasia/Hypoplasia of the tibia (HP:0005772)1.93838049
81Preaxial hand polydactyly (HP:0001177)1.93366796
82Increased hepatocellular lipid droplets (HP:0006565)1.91601484
83* Retinitis pigmentosa (HP:0000510)1.91083330
84Abnormality of the dental root (HP:0006486)1.89612171
85Taurodontia (HP:0000679)1.89612171
86Abnormality of permanent molar morphology (HP:0011071)1.89612171
87Chromosomal breakage induced by crosslinking agents (HP:0003221)1.89238413
88Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.88796611
89Oligodactyly (hands) (HP:0001180)1.88333462
90Severe visual impairment (HP:0001141)1.88051803
91Abnormality of the axillary hair (HP:0100134)1.86884158
92Abnormality of secondary sexual hair (HP:0009888)1.86884158
93Abnormality of molar morphology (HP:0011070)1.86880414
94Abnormality of molar (HP:0011077)1.86880414
95Dyschromatopsia (HP:0007641)1.86499605
96* Aganglionic megacolon (HP:0002251)1.85751875
97Hepatocellular necrosis (HP:0001404)1.85484901
98Morphological abnormality of the middle ear (HP:0008609)1.85455892
99Abnormality of the ischium (HP:0003174)1.85144165
100* Postaxial hand polydactyly (HP:0001162)1.85028272
1013-Methylglutaconic aciduria (HP:0003535)1.83929086
102Rib fusion (HP:0000902)1.83921625
103Fibular hypoplasia (HP:0003038)1.83849441
104Infertility (HP:0000789)1.83313271
105Widely spaced teeth (HP:0000687)1.80475579
106Increased cerebral lipofuscin (HP:0011813)1.80316333
107Tubulointerstitial nephritis (HP:0001970)1.79754947
108Chronic sinusitis (HP:0011109)1.78698813
109Aplasia/Hypoplasia of the tongue (HP:0010295)1.78483418
110Progressive cerebellar ataxia (HP:0002073)1.77475615
111Abnormality of the dental pulp (HP:0006479)1.76872518
112Prolonged QT interval (HP:0001657)1.76528958
113Abolished electroretinogram (ERG) (HP:0000550)1.76339521
114Concave nail (HP:0001598)1.76280735
115Central scotoma (HP:0000603)1.75919662
116Postaxial foot polydactyly (HP:0001830)1.75796433
117Macroglossia (HP:0000158)1.75289754
118Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.75065466
119Type II lissencephaly (HP:0007260)1.75059335
120Bell-shaped thorax (HP:0001591)1.74839763
121Atelectasis (HP:0100750)1.73264417
122Gaze-evoked nystagmus (HP:0000640)1.73253560
123Blue irides (HP:0000635)1.73062484
124Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72818091
125Bulbous nose (HP:0000414)1.72112756
126Polyphagia (HP:0002591)1.71398270
127Aplasia/hypoplasia of the uterus (HP:0008684)1.70880562
128* Astigmatism (HP:0000483)1.70459597
129Abnormality of incisor morphology (HP:0011063)1.68906271
130Hemiparesis (HP:0001269)1.68383054
131Congenital hepatic fibrosis (HP:0002612)1.67750047
132Highly arched eyebrow (HP:0002553)1.67641583
133Poor suck (HP:0002033)1.65653283
134Stage 5 chronic kidney disease (HP:0003774)1.64181371
135Esotropia (HP:0000565)1.64145877
136Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.63868408
137Degeneration of the lateral corticospinal tracts (HP:0002314)1.63868408
138Hypoplasia of the fovea (HP:0007750)1.63785031
139Aplasia/Hypoplasia of the fovea (HP:0008060)1.63785031
140Male pseudohermaphroditism (HP:0000037)1.63669450
141Keratoconus (HP:0000563)1.62234471
142Increased corneal curvature (HP:0100692)1.62234471
143Ulnar claw (HP:0001178)1.60675726
144* Specific learning disability (HP:0001328)1.60425825
145Aplasia of the musculature (HP:0100854)1.60000870
146Long toe (HP:0010511)1.58230155
147Patellar aplasia (HP:0006443)1.57146606
148Tubulointerstitial fibrosis (HP:0005576)1.57108979
149Tubulointerstitial abnormality (HP:0001969)1.56927171
150Renal dysplasia (HP:0000110)1.56816826
151Tented upper lip vermilion (HP:0010804)1.55995576
152Sleep apnea (HP:0010535)1.55031160
153Polycystic kidney dysplasia (HP:0000113)1.54351095
154Absent speech (HP:0001344)1.53148546

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.57232763
2CASK4.08869285
3PNCK3.26613912
4ACVR1B2.65443973
5TNIK2.41802799
6PLK42.21893188
7MAP2K72.20134977
8STK162.12396525
9DAPK21.98824528
10MARK11.95663410
11TRIB31.92235837
12EPHA41.87353324
13CDK191.87202516
14OXSR11.84641930
15PBK1.83647497
16MAPK131.83437688
17PLK21.77938990
18BCR1.76235133
19SIK21.75834998
20ADRBK21.74740647
21BMPR1B1.74735701
22AKT31.74314767
23STK391.68093460
24PDK41.67901561
25PDK31.67901561
26MUSK1.66706587
27PRKD31.64552837
28BMPR21.62842450
29TAOK31.61420571
30PRKD21.58542727
31NTRK31.55046313
32GRK71.52808010
33VRK11.50733607
34MAPKAPK31.50440297
35SRPK11.50117486
36IRAK21.43189876
37PDK21.37827502
38IRAK11.37229249
39CDK31.36980595
40NEK61.35464191
41YES11.33170726
42GRK11.32662884
43NTRK21.30110232
44CAMKK11.28402835
45MARK21.27996371
46MAP3K121.25703346
47PKN11.23131479
48GRK51.22364892
49EPHA31.21432929
50ICK1.21178633
51PKN21.20637051
52SIK11.20410767
53MAP3K61.18295950
54TNK21.17429995
55PRKCH1.12820158
56MKNK21.11389747
57MAP4K21.10628552
58DYRK21.10533107
59MAP3K71.05898661
60MAP3K111.05152926
61TYRO31.04791110
62STK381.04240953
63MAP3K41.03958842
64CDC42BPA1.03916569
65IRAK31.03338039
66DDR21.02317575
67MAPK151.01208017
68ZAK1.01183286
69PRPF4B0.99938751
70HIPK20.99727402
71FER0.97914207
72NUAK10.97892665
73CAMK2B0.97809515
74CAMK2A0.95426494
75TGFBR10.95412024
76NME10.94084038
77DYRK1A0.94044998
78RPS6KA20.93924053
79IRAK40.92991314
80MAPKAPK50.92925054
81MST40.92581646
82TRPM70.92256984
83PHKG20.92121347
84PHKG10.92121347
85RPS6KA60.90540153
86MKNK10.90086560
87EIF2AK20.88937527
88SIK30.87655250
89MAP2K40.87566047
90CHUK0.87067372
91EEF2K0.87012358
92PRKCE0.85816163
93INSRR0.84705841
94PRKCG0.83871459
95PLK30.82761845
96CAMK2D0.81056266
97BRAF0.80873083
98FES0.79013632
99PAK60.77693121
100TSSK60.77609612
101PAK30.76487228
102MINK10.75988879
103MAP2K60.74001922
104STK38L0.72919339
105WNK30.70765004
106PRKAA10.69746834
107CAMK40.68106079
108PIK3CA0.67146138
109MAPK120.66830213
110WEE10.66210943
111ADRBK10.65808711
112CAMKK20.63234190
113RIPK40.62952267
114FGR0.62731490
115ERBB20.61765267
116DYRK1B0.61459354
117MAP2K10.61128543
118PRKCZ0.60665339
119PINK10.60632368
120PRKD10.60223150
121PTK2B0.58899795
122PRKAA20.58864094
123ERBB30.58788409
124RET0.57959800
125CHEK20.57862255
126BRD40.56951913
127CAMK2G0.55876567
128RPS6KL10.55113484
129RPS6KC10.55113484
130PRKG10.53467039
131SGK10.53119473
132WNK10.53027777
133UHMK10.52518240
134PRKACA0.52017549
135BUB10.50105949
136WNK40.50070740
137CDK50.50006412
138FGFR20.46768867
139MTOR0.46555136
140SGK30.46142944
141EIF2AK30.46080428
142BRSK20.45575185
143PDGFRB0.44710603
144MAP3K20.44698744
145AURKA0.44598749
146ABL20.43328147
147SGK4940.42339953
148SGK2230.42339953
149DYRK30.39869941
150CSNK1G30.39214692
151PDPK10.38897265
152NLK0.38557006
153EPHB20.38182776
154STK240.37678643
155STK110.37461480
156MAPK70.37422997
157MAPK80.36463511
158MAP2K20.36215308
159CDK180.35883353
160CCNB10.35696795
161CDK11A0.34828709
162CSNK1G20.33569062
163CDK140.33321146
164CSNK2A10.31156707
165CAMK10.30986406
166OBSCN0.30859975
167CDK150.30407357
168SGK20.29949028

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.19843399
2Oxidative phosphorylation_Homo sapiens_hsa001903.76237209
3Nicotine addiction_Homo sapiens_hsa050333.24326156
4Parkinsons disease_Homo sapiens_hsa050122.73548876
5Huntingtons disease_Homo sapiens_hsa050162.70898428
6Collecting duct acid secretion_Homo sapiens_hsa049662.57608500
7Alzheimers disease_Homo sapiens_hsa050102.35318298
8Protein export_Homo sapiens_hsa030602.16247224
9Basal transcription factors_Homo sapiens_hsa030222.08476506
10Proteasome_Homo sapiens_hsa030502.03838673
11RNA polymerase_Homo sapiens_hsa030202.00073041
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.98521763
13Synaptic vesicle cycle_Homo sapiens_hsa047211.97368866
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.96567296
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.96277612
16Olfactory transduction_Homo sapiens_hsa047401.86926676
17ABC transporters_Homo sapiens_hsa020101.80072589
18Taste transduction_Homo sapiens_hsa047421.76933447
19Histidine metabolism_Homo sapiens_hsa003401.76618803
20Dorso-ventral axis formation_Homo sapiens_hsa043201.73671518
21Serotonergic synapse_Homo sapiens_hsa047261.71417208
22Morphine addiction_Homo sapiens_hsa050321.68140435
23Glutamatergic synapse_Homo sapiens_hsa047241.67761975
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.64312120
25GABAergic synapse_Homo sapiens_hsa047271.60066890
26Cardiac muscle contraction_Homo sapiens_hsa042601.59631453
27Amphetamine addiction_Homo sapiens_hsa050311.57397745
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.57065913
29Fanconi anemia pathway_Homo sapiens_hsa034601.53221408
30Vibrio cholerae infection_Homo sapiens_hsa051101.51662469
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.51582307
32Ether lipid metabolism_Homo sapiens_hsa005651.51288687
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.45582688
34Circadian entrainment_Homo sapiens_hsa047131.43210438
35Ribosome_Homo sapiens_hsa030101.41091746
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.40058158
37Purine metabolism_Homo sapiens_hsa002301.30994649
38Non-homologous end-joining_Homo sapiens_hsa034501.30992133
39Nitrogen metabolism_Homo sapiens_hsa009101.30138173
40Sphingolipid metabolism_Homo sapiens_hsa006001.28418786
41Calcium signaling pathway_Homo sapiens_hsa040201.28230057
42Glycerolipid metabolism_Homo sapiens_hsa005611.27318353
43SNARE interactions in vesicular transport_Homo sapiens_hsa041301.24480714
44Rheumatoid arthritis_Homo sapiens_hsa053231.24380643
45Vitamin B6 metabolism_Homo sapiens_hsa007501.19653388
46Homologous recombination_Homo sapiens_hsa034401.16367822
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.13804126
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11297529
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11169256
50Carbohydrate digestion and absorption_Homo sapiens_hsa049731.10050444
51Dopaminergic synapse_Homo sapiens_hsa047281.09533371
52Pyrimidine metabolism_Homo sapiens_hsa002401.07314511
53Protein digestion and absorption_Homo sapiens_hsa049741.06876043
54Renin secretion_Homo sapiens_hsa049241.01920129
55Arachidonic acid metabolism_Homo sapiens_hsa005901.01698571
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01246094
57Type II diabetes mellitus_Homo sapiens_hsa049301.01113477
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00456595
59Insulin secretion_Homo sapiens_hsa049110.96628528
60Salivary secretion_Homo sapiens_hsa049700.96467997
61Notch signaling pathway_Homo sapiens_hsa043300.96352361
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95733519
63Lysosome_Homo sapiens_hsa041420.95443960
64Linoleic acid metabolism_Homo sapiens_hsa005910.94233555
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.93376676
66Long-term depression_Homo sapiens_hsa047300.91532906
67Long-term potentiation_Homo sapiens_hsa047200.90793366
68Butanoate metabolism_Homo sapiens_hsa006500.89946227
69Cocaine addiction_Homo sapiens_hsa050300.88129296
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87540419
71beta-Alanine metabolism_Homo sapiens_hsa004100.86822532
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81444936
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80398315
74Nucleotide excision repair_Homo sapiens_hsa034200.80314160
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79979410
76Tryptophan metabolism_Homo sapiens_hsa003800.79042515
77Cholinergic synapse_Homo sapiens_hsa047250.77557423
78Lysine degradation_Homo sapiens_hsa003100.76672502
79Axon guidance_Homo sapiens_hsa043600.76338380
80Autoimmune thyroid disease_Homo sapiens_hsa053200.75755618
81Fatty acid elongation_Homo sapiens_hsa000620.75545191
82Fat digestion and absorption_Homo sapiens_hsa049750.74002876
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71168921
84MAPK signaling pathway_Homo sapiens_hsa040100.71032586
85GnRH signaling pathway_Homo sapiens_hsa049120.70742498
86Regulation of autophagy_Homo sapiens_hsa041400.69522603
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.69073598
88Chemical carcinogenesis_Homo sapiens_hsa052040.68999250
89Dilated cardiomyopathy_Homo sapiens_hsa054140.68199709
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68197455
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67502892
92Basal cell carcinoma_Homo sapiens_hsa052170.66692926
93Oocyte meiosis_Homo sapiens_hsa041140.63685081
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62539494
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60813523
96Spliceosome_Homo sapiens_hsa030400.60578403
97Bile secretion_Homo sapiens_hsa049760.60544912
98Gastric acid secretion_Homo sapiens_hsa049710.60510508
99Oxytocin signaling pathway_Homo sapiens_hsa049210.60493494
100Phagosome_Homo sapiens_hsa041450.59714640
101RNA degradation_Homo sapiens_hsa030180.59577326
102Hippo signaling pathway_Homo sapiens_hsa043900.59135227
103Choline metabolism in cancer_Homo sapiens_hsa052310.56889053
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.56599355
105Ovarian steroidogenesis_Homo sapiens_hsa049130.56059777
106Metabolic pathways_Homo sapiens_hsa011000.55804982
107Graft-versus-host disease_Homo sapiens_hsa053320.55264715
108Type I diabetes mellitus_Homo sapiens_hsa049400.55156083
109Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54901187
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.54685542
111Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52966823
112Thyroid hormone synthesis_Homo sapiens_hsa049180.50897103
113VEGF signaling pathway_Homo sapiens_hsa043700.50164371
114Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49892414
115Circadian rhythm_Homo sapiens_hsa047100.49122053
116Insulin resistance_Homo sapiens_hsa049310.48331385
117Inositol phosphate metabolism_Homo sapiens_hsa005620.47929227
118Estrogen signaling pathway_Homo sapiens_hsa049150.45801773
119Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45797472
120cAMP signaling pathway_Homo sapiens_hsa040240.45742884
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45734652
122Alcoholism_Homo sapiens_hsa050340.45680892
123Steroid biosynthesis_Homo sapiens_hsa001000.45571842
124AMPK signaling pathway_Homo sapiens_hsa041520.44500319
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43172787
126Mismatch repair_Homo sapiens_hsa034300.42881065
127African trypanosomiasis_Homo sapiens_hsa051430.42707660
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41864407
129Prolactin signaling pathway_Homo sapiens_hsa049170.40334298
130Allograft rejection_Homo sapiens_hsa053300.39117225
131Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38117129
132RNA transport_Homo sapiens_hsa030130.37149957
133Mineral absorption_Homo sapiens_hsa049780.37084104
134Wnt signaling pathway_Homo sapiens_hsa043100.35876950
135Glycerophospholipid metabolism_Homo sapiens_hsa005640.35632418
136Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32332899
137cGMP-PKG signaling pathway_Homo sapiens_hsa040220.29612615
138Pancreatic secretion_Homo sapiens_hsa049720.29536263
139Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28935081
140Ras signaling pathway_Homo sapiens_hsa040140.27151420
141Hedgehog signaling pathway_Homo sapiens_hsa043400.26208451
142Glutathione metabolism_Homo sapiens_hsa004800.26052035
143Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.24565994
144Asthma_Homo sapiens_hsa053100.23421444
145Sulfur metabolism_Homo sapiens_hsa009200.23348715
146Melanogenesis_Homo sapiens_hsa049160.22867776

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