BBS7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of eight proteins that form the BBSome complex containing BBS1, BBS2, BBS4, BBS5, BBS7, BBS8, BBS9 and BBIP10. The BBSome complex is believed to recruit Rab8(GTP) to the primary cilium and promote ciliogenesis. The BBSome complex assembly is mediated by a complex composed of three chaperonin-like BBS proteins (BBS6, BBS10, and BBS12) and CCT/TRiC family chaperonins. Mutations in this gene are implicated in Bardet-Biedl syndrome, a genetic disorder whose symptoms include obesity, retinal degeneration, polydactyly and nephropathy; however, mutations in this gene and the BBS8 gene are thought to play a minor role and mutations in chaperonin-like BBS genes are found to be a major contributor to disease development in a multiethnic Bardet-Biedl syndrome patient population. Two transcript variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of rhodopsin mediated signaling pathway (GO:0022400)8.10323819
2rhodopsin mediated signaling pathway (GO:0016056)7.75083358
3retinal cone cell development (GO:0046549)6.16044890
4photoreceptor cell development (GO:0042461)5.88401650
5photoreceptor cell maintenance (GO:0045494)5.68287214
6eye photoreceptor cell development (GO:0042462)5.59632977
7protein localization to synapse (GO:0035418)4.96284638
8detection of light stimulus involved in sensory perception (GO:0050962)4.93139237
9detection of light stimulus involved in visual perception (GO:0050908)4.93139237
10retinal rod cell development (GO:0046548)4.61498677
11cilium or flagellum-dependent cell motility (GO:0001539)4.60007258
12protein localization to cilium (GO:0061512)4.32639317
13phototransduction (GO:0007602)4.31560018
14regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.31209043
15GMP metabolic process (GO:0046037)4.28701919
16phototransduction, visible light (GO:0007603)4.22591054
17detection of light stimulus (GO:0009583)4.22143109
18detection of visible light (GO:0009584)4.19318546
19positive regulation of guanylate cyclase activity (GO:0031284)4.15184458
20synaptic vesicle exocytosis (GO:0016079)4.15183633
21positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.14431585
22regulation of short-term neuronal synaptic plasticity (GO:0048172)4.06013856
23synaptic vesicle docking involved in exocytosis (GO:0016081)4.00686337
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.93729260
25photoreceptor cell differentiation (GO:0046530)3.92472478
26eye photoreceptor cell differentiation (GO:0001754)3.92472478
27regulation of synaptic vesicle exocytosis (GO:2000300)3.80114533
28vocalization behavior (GO:0071625)3.79046715
29* nonmotile primary cilium assembly (GO:0035058)3.77938647
30neurotransmitter-gated ion channel clustering (GO:0072578)3.75810591
31* visual perception (GO:0007601)3.75512463
32* sensory perception of light stimulus (GO:0050953)3.71448596
33regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.68323661
34regulation of guanylate cyclase activity (GO:0031282)3.61043100
35regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.57262209
36epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.56002788
37epithelial cilium movement (GO:0003351)3.50562163
38neuron cell-cell adhesion (GO:0007158)3.48728791
39presynaptic membrane assembly (GO:0097105)3.44583200
40response to histamine (GO:0034776)3.40301963
41motile cilium assembly (GO:0044458)3.38833369
42striatum development (GO:0021756)3.36825755
43cullin deneddylation (GO:0010388)3.36455128
44intraciliary transport (GO:0042073)3.30528791
45startle response (GO:0001964)3.30528500
46glutamate secretion (GO:0014047)3.30433650
47regulation of synaptic vesicle transport (GO:1902803)3.30400568
48chaperone-mediated protein transport (GO:0072321)3.28916113
49protein deneddylation (GO:0000338)3.24969010
50detection of external stimulus (GO:0009581)3.22169269
51cilium movement (GO:0003341)3.21587694
52regulation of glutamate receptor signaling pathway (GO:1900449)3.21559199
53axonemal dynein complex assembly (GO:0070286)3.21028447
54regulation of cilium movement (GO:0003352)3.19164653
55detection of abiotic stimulus (GO:0009582)3.17925456
56regulation of voltage-gated calcium channel activity (GO:1901385)3.13189303
57acrosome reaction (GO:0007340)3.12306236
58lactate metabolic process (GO:0006089)3.11838460
59calcium ion-dependent exocytosis (GO:0017156)3.09799517
60behavioral response to cocaine (GO:0048148)3.08228112
61retina development in camera-type eye (GO:0060041)3.05754608
62synaptic vesicle maturation (GO:0016188)3.04829345
63positive regulation of synapse maturation (GO:0090129)3.04518577
64postsynaptic membrane organization (GO:0001941)3.01663546
65axoneme assembly (GO:0035082)3.00551347
66cellular response to light stimulus (GO:0071482)3.00549851
67neuron-neuron synaptic transmission (GO:0007270)2.97899815
68presynaptic membrane organization (GO:0097090)2.97247016
69positive regulation of neurotransmitter transport (GO:0051590)2.97067800
70membrane hyperpolarization (GO:0060081)2.96425609
71ATP hydrolysis coupled proton transport (GO:0015991)2.96354307
72energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.96354307
73regulation of neurotransmitter secretion (GO:0046928)2.95112882
74positive regulation of membrane potential (GO:0045838)2.91085374
75proteasome assembly (GO:0043248)2.90914513
76layer formation in cerebral cortex (GO:0021819)2.90442342
77neuron recognition (GO:0008038)2.89468762
78neurotransmitter secretion (GO:0007269)2.89459962
79synaptic vesicle endocytosis (GO:0048488)2.89210894
80sperm motility (GO:0030317)2.88965431
81regulation of penile erection (GO:0060405)2.88572869
82organelle disassembly (GO:1903008)2.87448985
83DNA damage response, detection of DNA damage (GO:0042769)2.86941495
84retina layer formation (GO:0010842)2.85172464
85regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.85135339
86regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.85135339
87transferrin transport (GO:0033572)2.82553448
88* cilium organization (GO:0044782)2.82514627
89proline transport (GO:0015824)2.82473251
90peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.82311666
91establishment of integrated proviral latency (GO:0075713)2.82198238
92synaptic transmission, glutamatergic (GO:0035249)2.81865717
93regulation of excitatory postsynaptic membrane potential (GO:0060079)2.81428906
94regulation of postsynaptic membrane potential (GO:0060078)2.81294791
95neuronal action potential propagation (GO:0019227)2.81201954
96* cilium assembly (GO:0042384)2.80953050
97chromatin remodeling at centromere (GO:0031055)2.80935338
98mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.80909047
99establishment of protein localization to mitochondrial membrane (GO:0090151)2.80532708
100positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.80238654
101regulation of development, heterochronic (GO:0040034)2.79588583
102neurotransmitter transport (GO:0006836)2.79223078
103pyrimidine nucleobase catabolic process (GO:0006208)2.78958737
104regulation of cGMP metabolic process (GO:0030823)2.78278562
105long-term synaptic potentiation (GO:0060291)2.78145334
106DNA double-strand break processing (GO:0000729)2.77269563
107detection of calcium ion (GO:0005513)2.76520478
108CENP-A containing nucleosome assembly (GO:0034080)2.75864215
109short-term memory (GO:0007614)2.75529488
110trivalent inorganic cation transport (GO:0072512)2.71251991
111ferric iron transport (GO:0015682)2.71251991
112protein-chromophore linkage (GO:0018298)2.70249834
113regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.69742502
114regulation of mitotic spindle checkpoint (GO:1903504)2.69742502
115protein complex biogenesis (GO:0070271)2.69560459
116mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.69468676
117mitochondrial respiratory chain complex I assembly (GO:0032981)2.69468676
118NADH dehydrogenase complex assembly (GO:0010257)2.69468676
119regulation of synaptic transmission, glutamatergic (GO:0051966)2.66894037
120limb bud formation (GO:0060174)2.66722143
121negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.66391980
122regulation of timing of cell differentiation (GO:0048505)2.63554995
123DNA ligation (GO:0006266)2.63142899
124positive regulation of mitochondrial fission (GO:0090141)2.59507979
125mitochondrial respiratory chain complex assembly (GO:0033108)2.58041677
126protein neddylation (GO:0045116)2.50872914
127axonal fasciculation (GO:0007413)2.50677011
128retinal ganglion cell axon guidance (GO:0031290)2.49903989
129ribonucleoprotein complex disassembly (GO:0032988)2.44273573
130protein-cofactor linkage (GO:0018065)2.42347702
131energy coupled proton transport, down electrochemical gradient (GO:0015985)2.40296276
132ATP synthesis coupled proton transport (GO:0015986)2.40296276
133otic vesicle formation (GO:0030916)2.38269371
134mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.37722167
135protein heterotetramerization (GO:0051290)2.37140824
136histone exchange (GO:0043486)2.34721210
137spermatid nucleus differentiation (GO:0007289)2.34533780
138microtubule polymerization or depolymerization (GO:0031109)2.34199480
139nucleobase catabolic process (GO:0046113)2.34059492
140non-recombinational repair (GO:0000726)2.33354929
141double-strand break repair via nonhomologous end joining (GO:0006303)2.33354929
142water-soluble vitamin biosynthetic process (GO:0042364)2.31275596
143regulation of helicase activity (GO:0051095)2.24112364
144microtubule depolymerization (GO:0007019)2.22123469
145resolution of meiotic recombination intermediates (GO:0000712)2.21883922
146cerebral cortex radially oriented cell migration (GO:0021799)2.21865105
147establishment of viral latency (GO:0019043)2.19670574
148metaphase plate congression (GO:0051310)2.17469145
149behavioral response to nicotine (GO:0035095)2.17399906
150neurofilament cytoskeleton organization (GO:0060052)2.15467724
151positive regulation of synapse assembly (GO:0051965)2.14743890
152DNA replication checkpoint (GO:0000076)2.13946003
153transmission of nerve impulse (GO:0019226)2.13711807
154protein polyglutamylation (GO:0018095)2.13658079
155spliceosomal snRNP assembly (GO:0000387)2.13549765
1567-methylguanosine mRNA capping (GO:0006370)2.12581252
157nucleobase biosynthetic process (GO:0046112)2.12002635
158negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.11402615
159regulation of feeding behavior (GO:0060259)2.10856024
160centriole replication (GO:0007099)2.09796388
161establishment of mitochondrion localization (GO:0051654)2.08262291
162regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.07761820
163hippocampus development (GO:0021766)2.07209866
164inner ear receptor stereocilium organization (GO:0060122)2.07000337
165behavioral response to ethanol (GO:0048149)2.06749358
166DNA replication-independent nucleosome organization (GO:0034724)2.06176905
167DNA replication-independent nucleosome assembly (GO:0006336)2.06176905
1687-methylguanosine RNA capping (GO:0009452)2.06047262
169RNA capping (GO:0036260)2.06047262
170respiratory chain complex IV assembly (GO:0008535)2.04617086
171olfactory bulb development (GO:0021772)2.04147941
172purine nucleobase biosynthetic process (GO:0009113)2.03888676
173regulation of centriole replication (GO:0046599)2.03196168
174negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.03189359
175negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.03189359
176negative regulation of mitotic sister chromatid segregation (GO:0033048)2.03189359
177negative regulation of mitotic sister chromatid separation (GO:2000816)2.03189359
178negative regulation of sister chromatid segregation (GO:0033046)2.03189359
179spindle checkpoint (GO:0031577)2.02886483
180anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.02617178
181negative regulation of DNA recombination (GO:0045910)2.02463816
182substrate-independent telencephalic tangential migration (GO:0021826)2.01615949
183substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.01615949
184exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.01032751

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.75145310
2GBX2_23144817_ChIP-Seq_PC3_Human4.04382711
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.12639454
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.75159905
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.70749928
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.57477930
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.53257600
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.36528591
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.36484824
10TAF15_26573619_Chip-Seq_HEK293_Human2.29630998
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.26562980
12ELK1_19687146_ChIP-ChIP_HELA_Human2.26497611
13REST_21632747_ChIP-Seq_MESCs_Mouse2.21485352
14EWS_26573619_Chip-Seq_HEK293_Human2.21131233
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.20998982
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.19551615
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16555639
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14812885
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.12392339
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.11613545
21VDR_22108803_ChIP-Seq_LS180_Human2.11172722
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04468251
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.01733609
24JARID2_20064375_ChIP-Seq_MESCs_Mouse2.00400324
25* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96780167
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96694937
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.95686681
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92375777
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.90987329
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.90801765
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.89272264
32JARID2_20075857_ChIP-Seq_MESCs_Mouse1.87547930
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.86981368
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.86177469
35EZH2_18974828_ChIP-Seq_MESCs_Mouse1.86154567
36RNF2_18974828_ChIP-Seq_MESCs_Mouse1.86154567
37* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.86129229
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85707512
39SMAD4_21799915_ChIP-Seq_A2780_Human1.83571430
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.83475331
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.83087404
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.82884390
43SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.82862481
44REST_18959480_ChIP-ChIP_MESCs_Mouse1.79188122
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.76682827
46ETS1_20019798_ChIP-Seq_JURKAT_Human1.76625589
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.75753784
48MTF2_20144788_ChIP-Seq_MESCs_Mouse1.74630615
49IGF1R_20145208_ChIP-Seq_DFB_Human1.73620559
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.70329477
51P300_19829295_ChIP-Seq_ESCs_Human1.69645300
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.68934093
53FUS_26573619_Chip-Seq_HEK293_Human1.67746345
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.66763207
55RNF2_27304074_Chip-Seq_ESCs_Mouse1.65125556
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65122644
57AR_21572438_ChIP-Seq_LNCaP_Human1.59233797
58MYC_18555785_ChIP-Seq_MESCs_Mouse1.59125850
59SUZ12_27294783_Chip-Seq_ESCs_Mouse1.58489456
60DROSHA_22980978_ChIP-Seq_HELA_Human1.55327638
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54304023
62KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.54270958
63MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.51383923
64RNF2_27304074_Chip-Seq_NSC_Mouse1.48891651
65RARB_27405468_Chip-Seq_BRAIN_Mouse1.48485078
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.48091110
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.46847194
68STAT3_23295773_ChIP-Seq_U87_Human1.46269177
69MYC_18940864_ChIP-ChIP_HL60_Human1.46050919
70THAP11_20581084_ChIP-Seq_MESCs_Mouse1.45134519
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44049403
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42852827
73JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.42824431
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42362995
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.41851296
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41776103
77ER_23166858_ChIP-Seq_MCF-7_Human1.41606858
78VDR_23849224_ChIP-Seq_CD4+_Human1.39805630
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.39502045
80CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39455101
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39205854
82E2F7_22180533_ChIP-Seq_HELA_Human1.38868385
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.38333769
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38280601
85YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37393804
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36010402
87FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35718130
88RBPJ_22232070_ChIP-Seq_NCS_Mouse1.33949925
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32390761
90ZNF274_21170338_ChIP-Seq_K562_Hela1.31251729
91NANOG_18555785_Chip-Seq_ESCs_Mouse1.30496755
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.30152965
93DCP1A_22483619_ChIP-Seq_HELA_Human1.28572179
94* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.26869253
95* TCF4_23295773_ChIP-Seq_U87_Human1.25378672
96AR_25329375_ChIP-Seq_VCAP_Human1.25067586
97* TTF2_22483619_ChIP-Seq_HELA_Human1.24841895
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24370473
99FLI1_27457419_Chip-Seq_LIVER_Mouse1.23596557
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23017950
101SOX2_21211035_ChIP-Seq_LN229_Gbm1.22984435
102CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.21132361
103CBP_20019798_ChIP-Seq_JUKART_Human1.20187204
104IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20187204
105PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19853335
106SOX9_26525672_Chip-Seq_HEART_Mouse1.19085519
107HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.18290413
108TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16277908
109KDM2B_26808549_Chip-Seq_REH_Human1.14323014
110NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14213222
111AR_19668381_ChIP-Seq_PC3_Human1.13846803
112FOXP3_21729870_ChIP-Seq_TREG_Human1.12892180
113FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12455242
114RUNX2_22187159_ChIP-Seq_PCA_Human1.11832038
115TAL1_26923725_Chip-Seq_HPCs_Mouse1.11564904
116FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.10821287
117EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10579320
118NELFA_20434984_ChIP-Seq_ESCs_Mouse1.09421526
119SOX2_16153702_ChIP-ChIP_HESCs_Human1.09354885
120* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08751904
121WT1_19549856_ChIP-ChIP_CCG9911_Human1.08627273
122E2F1_18555785_Chip-Seq_ESCs_Mouse1.08530248
123P53_22387025_ChIP-Seq_ESCs_Mouse1.08113341
124BCAT_22108803_ChIP-Seq_LS180_Human1.07154128
125CMYC_18555785_Chip-Seq_ESCs_Mouse1.06681706
126KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05741624
127NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05695850
128PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05365281
129HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.04833313
130CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03262602
131NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02341592
132TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02179118
133FLI1_21867929_ChIP-Seq_TH2_Mouse1.01609765
134JUN_21703547_ChIP-Seq_K562_Human1.00968123
135LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00716552
136ARNT_22903824_ChIP-Seq_MCF-7_Human1.00514650
137FOXM1_23109430_ChIP-Seq_U2OS_Human1.00272574
138IRF1_19129219_ChIP-ChIP_H3396_Human0.99094092
139RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98486790
140MYC_19030024_ChIP-ChIP_MESCs_Mouse0.97606209
141POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97482303
142NANOG_16153702_ChIP-ChIP_HESCs_Human0.97338185
143GABP_19822575_ChIP-Seq_HepG2_Human0.96156753
144POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93801374
145E2F1_18555785_ChIP-Seq_MESCs_Mouse0.93755737
146MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92034248
147XRN2_22483619_ChIP-Seq_HELA_Human0.91478766

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog5.28898111
2MP0003011_delayed_dark_adaptation4.34173219
3MP0005253_abnormal_eye_physiology3.57253251
4MP0006072_abnormal_retinal_apoptosis3.46384357
5MP0003880_abnormal_central_pattern3.41803113
6MP0004859_abnormal_synaptic_plasticity3.17693476
7MP0004270_analgesia2.77160184
8MP0009046_muscle_twitch2.60990972
9MP0003635_abnormal_synaptic_transmissio2.51911813
10MP0001984_abnormal_olfaction2.35968179
11MP0009745_abnormal_behavioral_response2.26894383
12MP0005410_abnormal_fertilization2.25983444
13MP0002064_seizures2.25725700
14MP0002063_abnormal_learning/memory/cond2.15847973
15MP0001968_abnormal_touch/_nociception2.13388562
16MP0002734_abnormal_mechanical_nocicepti2.13273371
17MP0005423_abnormal_somatic_nervous2.06689810
18MP0005195_abnormal_posterior_eye2.06038756
19MP0002572_abnormal_emotion/affect_behav2.05099048
20MP0001188_hyperpigmentation1.98088528
21MP0002822_catalepsy1.98002704
22MP0008058_abnormal_DNA_repair1.97494846
23MP0001486_abnormal_startle_reflex1.95582214
24MP0002272_abnormal_nervous_system1.95079218
25MP0000566_synostosis1.90577289
26MP0001324_abnormal_eye_pigmentation1.89492968
27MP0003950_abnormal_plasma_membrane1.88756423
28MP0006292_abnormal_olfactory_placode1.87160911
29MP0002229_neurodegeneration1.85465619
30MP0002735_abnormal_chemical_nociception1.80524438
31MP0002638_abnormal_pupillary_reflex1.79901174
32MP0003122_maternal_imprinting1.79886491
33MP0002736_abnormal_nociception_after1.75211114
34MP0005646_abnormal_pituitary_gland1.75185555
35MP0002882_abnormal_neuron_morphology1.73043149
36MP0005391_vision/eye_phenotype1.70141317
37MP0002067_abnormal_sensory_capabilities1.63265629
38MP0004233_abnormal_muscle_weight1.61852291
39MP0000778_abnormal_nervous_system1.61510579
40MP0002752_abnormal_somatic_nervous1.59942599
41MP0006276_abnormal_autonomic_nervous1.58378074
42MP0003136_yellow_coat_color1.56149534
43MP0002234_abnormal_pharynx_morphology1.55860323
44MP0002653_abnormal_ependyma_morphology1.55741316
45MP0002184_abnormal_innervation1.55297003
46MP0002938_white_spotting1.54237247
47MP0001293_anophthalmia1.49332594
48MP0008932_abnormal_embryonic_tissue1.47928386
49MP0003937_abnormal_limbs/digits/tail_de1.44944715
50MP0002557_abnormal_social/conspecific_i1.43981267
51MP0001986_abnormal_taste_sensitivity1.43775357
52MP0002090_abnormal_vision1.42376746
53MP0005645_abnormal_hypothalamus_physiol1.38797783
54MP0005499_abnormal_olfactory_system1.38268182
55MP0005394_taste/olfaction_phenotype1.38268182
56MP0009780_abnormal_chondrocyte_physiolo1.37036446
57MP0002233_abnormal_nose_morphology1.36913389
58MP0004811_abnormal_neuron_physiology1.36821144
59MP0003787_abnormal_imprinting1.34347083
60MP0010094_abnormal_chromosome_stability1.34133404
61MP0001502_abnormal_circadian_rhythm1.33071964
62MP0001970_abnormal_pain_threshold1.31233595
63MP0000049_abnormal_middle_ear1.27123362
64MP0003567_abnormal_fetal_cardiomyocyte1.26935580
65MP0003698_abnormal_male_reproductive1.26088222
66MP0001440_abnormal_grooming_behavior1.26049050
67MP0009697_abnormal_copulation1.25676750
68MP0002733_abnormal_thermal_nociception1.25328123
69MP0003283_abnormal_digestive_organ1.24364978
70MP0000955_abnormal_spinal_cord1.22888921
71MP0010386_abnormal_urinary_bladder1.22491647
72MP0008877_abnormal_DNA_methylation1.21191375
73MP0005386_behavior/neurological_phenoty1.19890870
74MP0004924_abnormal_behavior1.19890870
75MP0010030_abnormal_orbit_morphology1.19207409
76MP0002751_abnormal_autonomic_nervous1.19089642
77MP0004142_abnormal_muscle_tone1.14661507
78MP0005084_abnormal_gallbladder_morpholo1.13469208
79MP0004957_abnormal_blastocyst_morpholog1.13008428
80MP0000372_irregular_coat_pigmentation1.12924765
81MP0003755_abnormal_palate_morphology1.12571242
82MP0002837_dystrophic_cardiac_calcinosis1.12421848
83MP0005623_abnormal_meninges_morphology1.11484025
84MP0002697_abnormal_eye_size1.08954546
85MP0003385_abnormal_body_wall1.07568723
86MP0001529_abnormal_vocalization1.06098025
87MP0004043_abnormal_pH_regulation1.05582749
88MP0000647_abnormal_sebaceous_gland1.05384072
89MP0008569_lethality_at_weaning1.04437923
90MP0003634_abnormal_glial_cell1.04255623
91MP0003119_abnormal_digestive_system1.03300250
92MP0002066_abnormal_motor_capabilities/c1.02541054
93MP0008007_abnormal_cellular_replicative1.00851542
94MP0005367_renal/urinary_system_phenotyp1.00791957
95MP0000516_abnormal_urinary_system1.00791957
96MP0001501_abnormal_sleep_pattern1.00324606
97MP0000751_myopathy0.99923025
98MP0003786_premature_aging0.99311407
99MP0001286_abnormal_eye_development0.97967450
100MP0004133_heterotaxia0.97882955
101MP0003077_abnormal_cell_cycle0.95835958
102MP0003111_abnormal_nucleus_morphology0.95418861
103MP0002152_abnormal_brain_morphology0.94895231
104MP0005248_abnormal_Harderian_gland0.94345372
105MP0008789_abnormal_olfactory_epithelium0.94214746
106MP0004885_abnormal_endolymph0.92497450
107MP0003121_genomic_imprinting0.92455408
108MP0001905_abnormal_dopamine_level0.92435199
109MP0003693_abnormal_embryo_hatching0.91650735
110MP0000579_abnormal_nail_morphology0.90933553
111MP0000631_abnormal_neuroendocrine_gland0.89897007
112MP0006035_abnormal_mitochondrial_morpho0.89892410
113MP0001963_abnormal_hearing_physiology0.89602218
114MP0000537_abnormal_urethra_morphology0.88846291
115MP0000013_abnormal_adipose_tissue0.86904489
116MP0003938_abnormal_ear_development0.86465129
117MP0002282_abnormal_trachea_morphology0.85386764
118MP0005187_abnormal_penis_morphology0.82068269
119MP0004742_abnormal_vestibular_system0.81901369
120MP0003941_abnormal_skin_development0.80587732
121MP0002928_abnormal_bile_duct0.78679152
122MP0003718_maternal_effect0.78660577
123MP0002084_abnormal_developmental_patter0.78367515
124MP0004145_abnormal_muscle_electrophysio0.76306331
125MP0001177_atelectasis0.74823093
126MP0001929_abnormal_gametogenesis0.74506392
127MP0004085_abnormal_heartbeat0.73726661
128MP0001764_abnormal_homeostasis0.71823381
129MP0004858_abnormal_nervous_system0.71448454
130MP0000026_abnormal_inner_ear0.70714272
131MP0002102_abnormal_ear_morphology0.70374834
132MP0003890_abnormal_embryonic-extraembry0.69581656
133MP0002876_abnormal_thyroid_physiology0.68811235
134MP0003879_abnormal_hair_cell0.68594741
135MP0003633_abnormal_nervous_system0.66283081
136MP0002069_abnormal_eating/drinking_beha0.65088577
137MP0002161_abnormal_fertility/fecundity0.63961556
138MP0003861_abnormal_nervous_system0.62794361
139MP0003631_nervous_system_phenotype0.61579986
140MP0002909_abnormal_adrenal_gland0.61542355
141MP0000569_abnormal_digit_pigmentation0.58276755
142MP0003646_muscle_fatigue0.58204315
143MP0004215_abnormal_myocardial_fiber0.57826315
144MP0002160_abnormal_reproductive_system0.57554897
145MP0001299_abnormal_eye_distance/0.55561540

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)8.96475017
2Bony spicule pigmentary retinopathy (HP:0007737)6.77970140
3Abnormal rod and cone electroretinograms (HP:0008323)5.97514554
4Chorioretinal atrophy (HP:0000533)5.43073395
5Absent rod-and cone-mediated responses on ERG (HP:0007688)5.41087062
6Central scotoma (HP:0000603)5.31381758
7Abnormality of macular pigmentation (HP:0008002)5.01509109
8Pigmentary retinal degeneration (HP:0001146)4.81921291
9Pendular nystagmus (HP:0012043)4.79289689
10Attenuation of retinal blood vessels (HP:0007843)4.67972630
11Scotoma (HP:0000575)4.38457909
12* Gait imbalance (HP:0002141)4.27680310
13Dyschromatopsia (HP:0007641)4.24480225
14Decreased central vision (HP:0007663)4.21764559
15* Congenital primary aphakia (HP:0007707)4.14601640
16* Medial flaring of the eyebrow (HP:0010747)4.09852743
17Abolished electroretinogram (ERG) (HP:0000550)4.09567639
18* Nephrogenic diabetes insipidus (HP:0009806)3.87464174
19Type II diabetes mellitus (HP:0005978)3.74232194
20Severe visual impairment (HP:0001141)3.58198295
21Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.57037925
22Absent/shortened dynein arms (HP:0200106)3.53979958
23Dynein arm defect of respiratory motile cilia (HP:0012255)3.53979958
24Focal motor seizures (HP:0011153)3.52797512
25* Retinitis pigmentosa (HP:0000510)3.45829372
26Photophobia (HP:0000613)3.43273702
27Epileptic encephalopathy (HP:0200134)3.38107763
28Choroideremia (HP:0001139)3.28600768
29Methylmalonic acidemia (HP:0002912)3.26042165
30* Vaginal atresia (HP:0000148)3.24679887
31* Genital tract atresia (HP:0001827)3.20500683
32* Poor coordination (HP:0002370)3.14811746
33True hermaphroditism (HP:0010459)3.14796874
34Abnormal respiratory motile cilium physiology (HP:0012261)3.00107457
35Increased corneal curvature (HP:0100692)2.98578982
36Keratoconus (HP:0000563)2.98578982
37Macular degeneration (HP:0000608)2.92481547
38Abnormal respiratory motile cilium morphology (HP:0005938)2.90624009
39Abnormal respiratory epithelium morphology (HP:0012253)2.90624009
40Cone-rod dystrophy (HP:0000548)2.88752322
41Febrile seizures (HP:0002373)2.88414378
42Pancreatic fibrosis (HP:0100732)2.86585166
43Hyperventilation (HP:0002883)2.86155538
44Atonic seizures (HP:0010819)2.85532418
45Abnormal ciliary motility (HP:0012262)2.72255699
46Abnormality of the labia minora (HP:0012880)2.69411156
47Vitreoretinal degeneration (HP:0000655)2.63928143
48Focal seizures (HP:0007359)2.63051792
49Type II lissencephaly (HP:0007260)2.61760445
50Acute necrotizing encephalopathy (HP:0006965)2.61538035
51Decreased electroretinogram (ERG) amplitude (HP:0000654)2.59388641
52Abnormality of midbrain morphology (HP:0002418)2.52313834
53Molar tooth sign on MRI (HP:0002419)2.52313834
54Rhinitis (HP:0012384)2.50395304
55Progressive cerebellar ataxia (HP:0002073)2.48720981
56* Aplasia/Hypoplasia of the lens (HP:0008063)2.48282434
57Constricted visual fields (HP:0001133)2.46849593
58Methylmalonic aciduria (HP:0012120)2.46377063
59Optic disc pallor (HP:0000543)2.42813532
60Visual hallucinations (HP:0002367)2.36780274
61Limb dystonia (HP:0002451)2.32115487
62Abnormal mitochondria in muscle tissue (HP:0008316)2.28884598
63Myokymia (HP:0002411)2.28791803
64Nephronophthisis (HP:0000090)2.28181011
65Progressive macrocephaly (HP:0004481)2.28167388
66Truncal ataxia (HP:0002078)2.26844914
67* Specific learning disability (HP:0001328)2.25859257
68Absence seizures (HP:0002121)2.23823089
69Abnormality of glycolysis (HP:0004366)2.23520371
70Retinal dysplasia (HP:0007973)2.21137334
71Acute encephalopathy (HP:0006846)2.20850977
72Pancreatic cysts (HP:0001737)2.19680592
73Cystic liver disease (HP:0006706)2.14503160
74Increased serum pyruvate (HP:0003542)2.12152975
75Stenosis of the external auditory canal (HP:0000402)2.07980208
76Hyperglycinemia (HP:0002154)2.06180037
77Split foot (HP:0001839)2.03476748
78Increased hepatocellular lipid droplets (HP:0006565)2.01741269
79Mitochondrial inheritance (HP:0001427)1.99940802
80Cortical dysplasia (HP:0002539)1.99665052
81* Broad foot (HP:0001769)1.97823122
82Abnormal hair whorl (HP:0010721)1.97112482
83Dialeptic seizures (HP:0011146)1.95306445
84Aplasia/Hypoplasia of the tongue (HP:0010295)1.94686040
85Generalized tonic-clonic seizures (HP:0002069)1.92379694
86Cerebellar dysplasia (HP:0007033)1.92316170
87Posterior subcapsular cataract (HP:0007787)1.92084838
88Increased CSF lactate (HP:0002490)1.91034554
89* Postaxial hand polydactyly (HP:0001162)1.89816597
90Gaze-evoked nystagmus (HP:0000640)1.89796841
91Abnormality of the vitamin B12 metabolism (HP:0004341)1.88207661
92Optic nerve hypoplasia (HP:0000609)1.87980518
93Atrophy/Degeneration involving motor neurons (HP:0007373)1.86794289
94Septo-optic dysplasia (HP:0100842)1.85738080
95Polyphagia (HP:0002591)1.85693440
96Intestinal atresia (HP:0011100)1.85005680
97Abnormality of the lower motor neuron (HP:0002366)1.84156028
98Absent septum pellucidum (HP:0001331)1.83904917
99Degeneration of anterior horn cells (HP:0002398)1.83467834
100Abnormality of the anterior horn cell (HP:0006802)1.83467834
101Absent speech (HP:0001344)1.83092613
102Impaired vibration sensation in the lower limbs (HP:0002166)1.82903694
103Abnormality of the septum pellucidum (HP:0007375)1.81894589
104Bifid tongue (HP:0010297)1.80093389
105Abnormality of vitamin B metabolism (HP:0004340)1.78175025
106Hepatocellular necrosis (HP:0001404)1.77823857
107Dysdiadochokinesis (HP:0002075)1.77690033
108Abnormality of the musculature of the pelvis (HP:0001469)1.74657665
109Abnormality of the hip-girdle musculature (HP:0001445)1.74657665
110Lissencephaly (HP:0001339)1.73980218
111Lipid accumulation in hepatocytes (HP:0006561)1.73361632
112Colon cancer (HP:0003003)1.73226895
113Tubulointerstitial nephritis (HP:0001970)1.73094777
114Shoulder girdle muscle weakness (HP:0003547)1.72103516
115Occipital encephalocele (HP:0002085)1.71998182
116Wide nasal bridge (HP:0000431)1.71553776
117Renal cortical cysts (HP:0000803)1.71537679
118Delayed gross motor development (HP:0002194)1.70507164
119Postaxial foot polydactyly (HP:0001830)1.69377141
120Chronic bronchitis (HP:0004469)1.69362970
121Congenital sensorineural hearing impairment (HP:0008527)1.69263293
122Sclerocornea (HP:0000647)1.68754906
123Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.68282983
124* Short foot (HP:0001773)1.67986548
125Labial hypoplasia (HP:0000066)1.67839004
126Abnormality of the renal medulla (HP:0100957)1.67773275
127Megalencephaly (HP:0001355)1.67627753
128Abnormality of the corticospinal tract (HP:0002492)1.67242807
129Retinal atrophy (HP:0001105)1.66503340
130Hepatic necrosis (HP:0002605)1.66417348
131Infertility (HP:0000789)1.66149085
132Cutaneous finger syndactyly (HP:0010554)1.65601329
133Broad-based gait (HP:0002136)1.65572448
134Preaxial hand polydactyly (HP:0001177)1.65427298
135Aplasia/Hypoplasia of the uvula (HP:0010293)1.64996641
136* Left ventricular hypertrophy (HP:0001712)1.64787495
137* Astigmatism (HP:0000483)1.63517144
138EEG with generalized epileptiform discharges (HP:0011198)1.63287691
139Abnormality of the pons (HP:0007361)1.62848021
140Gastrointestinal atresia (HP:0002589)1.62580386
141Hypoplastic female external genitalia (HP:0012815)1.62124510
142Hypsarrhythmia (HP:0002521)1.62087266
143Meckel diverticulum (HP:0002245)1.62079930
144Progressive inability to walk (HP:0002505)1.62044770
145Amyotrophic lateral sclerosis (HP:0007354)1.61358701
146Hypoplastic pelvis (HP:0008839)1.60677556
147Aqueductal stenosis (HP:0002410)1.60452926
148Postnatal microcephaly (HP:0005484)1.59529653
149Medulloblastoma (HP:0002885)1.58301648
150Pheochromocytoma (HP:0002666)1.58230423
151Muscular hypotonia of the trunk (HP:0008936)1.58032131
152Epileptiform EEG discharges (HP:0011182)1.57873719
153Urinary bladder sphincter dysfunction (HP:0002839)1.57689292
154Degeneration of the lateral corticospinal tracts (HP:0002314)1.57658263
155Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.57658263
156Congenital hepatic fibrosis (HP:0002612)1.56939254
157Action tremor (HP:0002345)1.56825699
158Hypoplasia of the pons (HP:0012110)1.56740263
159Esophageal atresia (HP:0002032)1.56652978
160Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.56565621
161Abnormality of alanine metabolism (HP:0010916)1.56565621
162Hyperalaninemia (HP:0003348)1.56565621
163Abnormal lung lobation (HP:0002101)1.56193353
164Cholecystitis (HP:0001082)1.54272908
165Abnormal gallbladder physiology (HP:0012438)1.54272908
166Amblyopia (HP:0000646)1.54200786
167Excessive salivation (HP:0003781)1.53226848
168Drooling (HP:0002307)1.53226848

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.73447805
2NTRK33.01594835
3BUB12.74634594
4MAP3K42.73102004
5SRPK12.69570877
6EPHA42.68983877
7PDK42.65095665
8PDK32.65095665
9MAP2K72.60068961
10PLK22.53176128
11GRK12.44662112
12AKT32.39725364
13PBK2.36651237
14TRIM282.34029291
15PRKD32.02560637
16MARK11.84275848
17MAP3K121.79244996
18PDK21.75881718
19MINK11.72950123
20SGK4941.68909171
21SGK2231.68909171
22SGK21.63627421
23CCNB11.58194431
24CDC71.55117035
25WNK41.53344609
26WEE11.48979806
27WNK31.46214108
28PAK61.46082873
29PTK2B1.45464590
30CSNK1G31.44433083
31VRK11.41937557
32DYRK21.39389807
33MAP2K41.39357718
34BMPR1B1.37319523
35PRPF4B1.36015141
36NTRK21.32812406
37SIK31.32655502
38CSNK1G11.31964722
39TTK1.31269021
40MKNK11.30672012
41PLK41.29652862
42PRKCG1.29381406
43CSNK1A1L1.27817441
44BRSK21.23876188
45MAPK131.23870410
46GRK51.22907460
47BCR1.22721677
48WNK11.21891241
49CDK51.12061083
50PNCK1.11905401
51STK161.11155434
52RPS6KA41.10973015
53MAP3K91.10379525
54DYRK31.10278689
55PLK11.09631835
56DAPK21.07133341
57OXSR11.06886821
58DAPK11.00981498
59CAMK2A1.00710696
60KSR10.99639581
61NTRK10.97807311
62ZAK0.95946069
63SGK30.94698243
64ADRBK10.94223926
65EPHB20.94126135
66BMPR20.93710062
67EIF2AK10.93635706
68TAF10.93351406
69EIF2AK30.92055018
70MAPK150.89297802
71MAP4K20.89275323
72NUAK10.89126935
73BRAF0.88552170
74ICK0.83945963
75PHKG20.83266419
76PHKG10.83266419
77PINK10.81271283
78PRKCE0.80994369
79CDK190.80270664
80ERBB30.80236929
81STK390.78884013
82STK380.76985035
83CDK180.75769350
84UHMK10.75199582
85FGFR20.74311105
86TNIK0.73760407
87TESK10.72129303
88IRAK20.72069110
89NEK60.70980686
90FER0.70483577
91CDK140.70117831
92BRSK10.67316676
93SGK10.66627955
94DYRK1A0.66108094
95CDK150.65446894
96PRKCZ0.65182217
97LIMK10.64833694
98YES10.61511724
99PAK30.60540965
100FRK0.60476019
101CDK30.60239824
102PLK30.59289895
103CAMK2D0.58688372
104ATM0.57139324
105DMPK0.56858985
106PRKCH0.56674826
107CAMK2B0.56035471
108PASK0.55826635
109MST40.55319120
110CAMKK20.55046810
111PKN10.53998384
112RAF10.53509721
113ERBB40.53186369
114FGFR10.52575776
115EPHA30.50858095
116CAMKK10.50801844
117CSNK1E0.50757393
118CDK11A0.49808877
119AURKB0.47651417
120SCYL20.45861084
121RPS6KA30.45773473
122TSSK60.45754477
123PRKCB0.43309819
124CSNK1G20.42487943
125MKNK20.42099988
126MAPK70.41844417
127RPS6KA20.41287345
128MAP3K50.41244476
129SIK20.40536486
130STK38L0.40386228
131BRD40.40341370
132STK30.39616115
133ATR0.39020054
134NME10.38985855
135ARAF0.38560345
136PRKACA0.37944517
137NEK10.37300648
138MAPK100.37222818
139RPS6KB10.36712628
140ROCK20.35702474
141CAMK1G0.32464103
142GSK3B0.31730117
143PRKG10.31710929

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047449.43448821
2Synaptic vesicle cycle_Homo sapiens_hsa047213.77024867
3Protein export_Homo sapiens_hsa030603.53765702
4Nicotine addiction_Homo sapiens_hsa050332.87415399
5Olfactory transduction_Homo sapiens_hsa047402.66722899
6Collecting duct acid secretion_Homo sapiens_hsa049662.61985983
7Proteasome_Homo sapiens_hsa030502.50999914
8GABAergic synapse_Homo sapiens_hsa047272.29487032
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.24837311
10Morphine addiction_Homo sapiens_hsa050322.18116080
11Circadian entrainment_Homo sapiens_hsa047132.10986346
12Mismatch repair_Homo sapiens_hsa034302.00360410
13Non-homologous end-joining_Homo sapiens_hsa034501.89212371
14Glutamatergic synapse_Homo sapiens_hsa047241.86477147
15Basal transcription factors_Homo sapiens_hsa030221.85443488
16Dopaminergic synapse_Homo sapiens_hsa047281.82196715
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.81748776
18Insulin secretion_Homo sapiens_hsa049111.81511369
19Fanconi anemia pathway_Homo sapiens_hsa034601.80962998
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.75173296
21RNA polymerase_Homo sapiens_hsa030201.72366140
22Amphetamine addiction_Homo sapiens_hsa050311.72004259
23Ribosome_Homo sapiens_hsa030101.70238013
24Homologous recombination_Homo sapiens_hsa034401.70189817
25Vibrio cholerae infection_Homo sapiens_hsa051101.60757528
26Long-term potentiation_Homo sapiens_hsa047201.60355189
27RNA degradation_Homo sapiens_hsa030181.59178748
28RNA transport_Homo sapiens_hsa030131.58820303
29Nucleotide excision repair_Homo sapiens_hsa034201.55857814
30DNA replication_Homo sapiens_hsa030301.52590523
31Serotonergic synapse_Homo sapiens_hsa047261.47610038
32Cholinergic synapse_Homo sapiens_hsa047251.45037034
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.43805942
34Spliceosome_Homo sapiens_hsa030401.43398760
35Taste transduction_Homo sapiens_hsa047421.36293293
36Steroid biosynthesis_Homo sapiens_hsa001001.35155488
37Renin secretion_Homo sapiens_hsa049241.29984849
38Cocaine addiction_Homo sapiens_hsa050301.28089733
39Cell cycle_Homo sapiens_hsa041101.19182214
40Folate biosynthesis_Homo sapiens_hsa007901.18589505
41Salivary secretion_Homo sapiens_hsa049701.18039266
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.15078287
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15066970
44Butanoate metabolism_Homo sapiens_hsa006501.13128549
45One carbon pool by folate_Homo sapiens_hsa006701.11860938
46Calcium signaling pathway_Homo sapiens_hsa040201.09814751
47Base excision repair_Homo sapiens_hsa034101.06336990
48Aldosterone synthesis and secretion_Homo sapiens_hsa049251.06288624
49Pyrimidine metabolism_Homo sapiens_hsa002401.04856152
50Oxytocin signaling pathway_Homo sapiens_hsa049211.04769553
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04446131
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.03742102
53Oxidative phosphorylation_Homo sapiens_hsa001901.01534037
54Fatty acid elongation_Homo sapiens_hsa000621.00665201
55Cardiac muscle contraction_Homo sapiens_hsa042601.00015175
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.99300722
57Gastric acid secretion_Homo sapiens_hsa049710.99274187
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99062640
59Pyruvate metabolism_Homo sapiens_hsa006200.98138654
60mRNA surveillance pathway_Homo sapiens_hsa030150.97789903
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97067038
62Long-term depression_Homo sapiens_hsa047300.97030236
63Axon guidance_Homo sapiens_hsa043600.96381960
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94956666
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92636968
66Regulation of autophagy_Homo sapiens_hsa041400.91913424
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88746030
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.87334249
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87239964
70Oocyte meiosis_Homo sapiens_hsa041140.85555191
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85285167
72Glucagon signaling pathway_Homo sapiens_hsa049220.84879668
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83459122
74cAMP signaling pathway_Homo sapiens_hsa040240.83410290
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78659391
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76084328
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75610770
78Biosynthesis of amino acids_Homo sapiens_hsa012300.74084715
79Basal cell carcinoma_Homo sapiens_hsa052170.72827805
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71103137
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70429404
82Circadian rhythm_Homo sapiens_hsa047100.69348372
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67701908
84p53 signaling pathway_Homo sapiens_hsa041150.67355840
85Phagosome_Homo sapiens_hsa041450.66516537
86Alcoholism_Homo sapiens_hsa050340.66083720
87Gap junction_Homo sapiens_hsa045400.66079060
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.65334748
89Huntingtons disease_Homo sapiens_hsa050160.65001159
90Type II diabetes mellitus_Homo sapiens_hsa049300.64771653
91Selenocompound metabolism_Homo sapiens_hsa004500.64742621
922-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63716998
93Carbon metabolism_Homo sapiens_hsa012000.63366074
94Melanogenesis_Homo sapiens_hsa049160.61851524
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61304498
96Alzheimers disease_Homo sapiens_hsa050100.61004256
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.58241860
98ErbB signaling pathway_Homo sapiens_hsa040120.57575823
99GnRH signaling pathway_Homo sapiens_hsa049120.56655381
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56471463
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55977857
102Rheumatoid arthritis_Homo sapiens_hsa053230.55922421
103Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55268335
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54663009
105Dilated cardiomyopathy_Homo sapiens_hsa054140.54251896
106Metabolic pathways_Homo sapiens_hsa011000.52576117
107Peroxisome_Homo sapiens_hsa041460.52540322
108Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51830885
109Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51220820
110Estrogen signaling pathway_Homo sapiens_hsa049150.50757048
111Sulfur metabolism_Homo sapiens_hsa009200.49782774
112N-Glycan biosynthesis_Homo sapiens_hsa005100.47754066
113TGF-beta signaling pathway_Homo sapiens_hsa043500.46648694
114Parkinsons disease_Homo sapiens_hsa050120.46530618
115Thyroid hormone synthesis_Homo sapiens_hsa049180.44784762
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42652533
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41987867
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41646855
119Wnt signaling pathway_Homo sapiens_hsa043100.41469181
120Inositol phosphate metabolism_Homo sapiens_hsa005620.40345979
121Hedgehog signaling pathway_Homo sapiens_hsa043400.38927105
122Fructose and mannose metabolism_Homo sapiens_hsa000510.38697287
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37321814
124Ovarian steroidogenesis_Homo sapiens_hsa049130.37164769
125Nitrogen metabolism_Homo sapiens_hsa009100.37148589
126Ras signaling pathway_Homo sapiens_hsa040140.36695530
127Fatty acid biosynthesis_Homo sapiens_hsa000610.35546115
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35410810
129Glioma_Homo sapiens_hsa052140.35207795
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35095806
131MAPK signaling pathway_Homo sapiens_hsa040100.34955383
132Arginine and proline metabolism_Homo sapiens_hsa003300.34642835
133beta-Alanine metabolism_Homo sapiens_hsa004100.34239186
134Purine metabolism_Homo sapiens_hsa002300.32868941
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32213179
136Dorso-ventral axis formation_Homo sapiens_hsa043200.31978837
137Pancreatic secretion_Homo sapiens_hsa049720.30868671
138Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30365414
139Type I diabetes mellitus_Homo sapiens_hsa049400.28881709
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28827053
141Propanoate metabolism_Homo sapiens_hsa006400.28586781
142Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26562007
143Endocytosis_Homo sapiens_hsa041440.23049648
144Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.22824737
145Melanoma_Homo sapiens_hsa052180.21378168
146Mineral absorption_Homo sapiens_hsa049780.21239597
147Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19933565
148Tight junction_Homo sapiens_hsa045300.19880528
149mTOR signaling pathway_Homo sapiens_hsa041500.19400812
150Hippo signaling pathway_Homo sapiens_hsa043900.18559348
151Insulin signaling pathway_Homo sapiens_hsa049100.18254736
152Longevity regulating pathway - mammal_Homo sapiens_hsa042110.15627964
153Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.14961616

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