BBS9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is downregulated by parathyroid hormone in osteoblastic cells, and therefore is thought to be involved in parathyroid hormone action in bones. The exact function of this gene has not yet been determined. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of rhodopsin mediated signaling pathway (GO:0022400)7.82667679
2rhodopsin mediated signaling pathway (GO:0016056)7.59604210
3retinal cone cell development (GO:0046549)7.15063703
4photoreceptor cell maintenance (GO:0045494)6.68780166
5retinal rod cell development (GO:0046548)6.53357223
6photoreceptor cell development (GO:0042461)6.25348610
7detection of light stimulus involved in visual perception (GO:0050908)6.21719351
8detection of light stimulus involved in sensory perception (GO:0050962)6.21719351
9eye photoreceptor cell development (GO:0042462)5.99649578
10piRNA metabolic process (GO:0034587)5.75400039
11cilium or flagellum-dependent cell motility (GO:0001539)5.57985303
12motile cilium assembly (GO:0044458)5.44982111
13photoreceptor cell differentiation (GO:0046530)5.28536922
14eye photoreceptor cell differentiation (GO:0001754)5.28536922
15male meiosis (GO:0007140)5.23616438
16otic vesicle formation (GO:0030916)5.13611027
17epithelial cilium movement (GO:0003351)5.04812094
18axonemal dynein complex assembly (GO:0070286)4.93336225
19axoneme assembly (GO:0035082)4.87850819
20protein-chromophore linkage (GO:0018298)4.80411710
21fusion of sperm to egg plasma membrane (GO:0007342)4.77418704
22cilium movement (GO:0003341)4.72606880
23sperm motility (GO:0030317)4.70095346
24epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.66122445
25regulation of cilium movement (GO:0003352)4.54310105
26nonmotile primary cilium assembly (GO:0035058)4.53079883
27phototransduction (GO:0007602)4.41770796
28detection of visible light (GO:0009584)4.36568761
29detection of light stimulus (GO:0009583)4.33218484
30phototransduction, visible light (GO:0007603)4.31347847
31* visual perception (GO:0007601)4.30403857
32acrosome reaction (GO:0007340)4.25186409
33* sensory perception of light stimulus (GO:0050953)4.25066898
34acrosome assembly (GO:0001675)4.19536732
35DNA methylation involved in gamete generation (GO:0043046)4.14296924
36multicellular organism reproduction (GO:0032504)4.12812055
37retina development in camera-type eye (GO:0060041)4.07331577
38sperm-egg recognition (GO:0035036)4.07308844
39synaptonemal complex organization (GO:0070193)3.97828148
40spermatid development (GO:0007286)3.96969699
41binding of sperm to zona pellucida (GO:0007339)3.94136856
42synaptonemal complex assembly (GO:0007130)3.89072175
43intraciliary transport (GO:0042073)3.85226241
44GMP metabolic process (GO:0046037)3.79934777
45protein polyglutamylation (GO:0018095)3.74417736
46macroautophagy (GO:0016236)3.73434821
47microtubule depolymerization (GO:0007019)3.71201492
48cell-cell recognition (GO:0009988)3.66117907
49protein localization to cilium (GO:0061512)3.65545887
50cellular response to light stimulus (GO:0071482)3.65264923
51single strand break repair (GO:0000012)3.61663753
52plasma membrane fusion (GO:0045026)3.60037504
53ventricular system development (GO:0021591)3.58965234
54microtubule severing (GO:0051013)3.56332220
55cell wall macromolecule catabolic process (GO:0016998)3.49216119
56cell wall macromolecule metabolic process (GO:0044036)3.49216119
57* cilium organization (GO:0044782)3.42456078
58reproduction (GO:0000003)3.32772028
59regulation of DNA methylation (GO:0044030)3.31768695
60* cilium assembly (GO:0042384)3.26239431
61positive regulation of guanylate cyclase activity (GO:0031284)3.23196142
62establishment of protein localization to Golgi (GO:0072600)3.22987813
63negative regulation of inclusion body assembly (GO:0090084)3.19043256
64regulation of gene silencing by RNA (GO:0060966)3.16819258
65regulation of posttranscriptional gene silencing (GO:0060147)3.16819258
66regulation of gene silencing by miRNA (GO:0060964)3.16819258
67paraxial mesoderm development (GO:0048339)3.16365087
68detection of external stimulus (GO:0009581)3.15325735
69protein targeting to Golgi (GO:0000042)3.14457883
70detection of abiotic stimulus (GO:0009582)3.14157663
71negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.10421620
72negative regulation of translation, ncRNA-mediated (GO:0040033)3.10421620
73regulation of translation, ncRNA-mediated (GO:0045974)3.10421620
74left/right axis specification (GO:0070986)3.07089628
75centriole replication (GO:0007099)3.06042922
76spermatogenesis (GO:0007283)3.04857765
77male gamete generation (GO:0048232)3.04342681
78cilium morphogenesis (GO:0060271)3.03630227
79meiotic cell cycle (GO:0051321)2.99254425
80regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.98433781
81pre-miRNA processing (GO:0031054)2.98226069
82negative regulation of organelle assembly (GO:1902116)2.97972316
83gamete generation (GO:0007276)2.97372249
84response to pheromone (GO:0019236)2.95350373
85meiotic nuclear division (GO:0007126)2.93582519
86regulation of centriole replication (GO:0046599)2.93536387
87presynaptic membrane assembly (GO:0097105)2.93426460
88regulation of microtubule-based movement (GO:0060632)2.92101524
89mitotic sister chromatid cohesion (GO:0007064)2.91737796
90pyrimidine nucleobase catabolic process (GO:0006208)2.90956100
91sensory perception of smell (GO:0007608)2.88922103
92chromosome organization involved in meiosis (GO:0070192)2.88601945
93single fertilization (GO:0007338)2.87581359
94synapsis (GO:0007129)2.87166275
95positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.86857599
96retrograde transport, vesicle recycling within Golgi (GO:0000301)2.86661744
97regulation of meiosis I (GO:0060631)2.84759896
98microtubule bundle formation (GO:0001578)2.80139382
99fertilization (GO:0009566)2.77107760
100presynaptic membrane organization (GO:0097090)2.75157231
101germ cell development (GO:0007281)2.74055066
102retina layer formation (GO:0010842)2.73876800
103* cellular component assembly involved in morphogenesis (GO:0010927)2.70368991
104male meiosis I (GO:0007141)2.70241928
105chromosome condensation (GO:0030261)2.69501395
106regulation of guanylate cyclase activity (GO:0031282)2.69158240
107microtubule polymerization or depolymerization (GO:0031109)2.67586132
108regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.67257239
109positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.67257239
110protein localization to chromosome, centromeric region (GO:0071459)2.63693336
111DNA packaging (GO:0006323)2.63271516
112prenylation (GO:0097354)2.61033345
113protein prenylation (GO:0018342)2.61033345
114regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.60105139
115regulation of mitotic spindle checkpoint (GO:1903504)2.60105139
116limb development (GO:0060173)2.59662576
117appendage development (GO:0048736)2.59662576
118centriole assembly (GO:0098534)2.58551560
119gene silencing by RNA (GO:0031047)2.56076062
120cellular process involved in reproduction in multicellular organism (GO:0022412)2.56014784
121microtubule-based movement (GO:0007018)2.55689587
122negative regulation of DNA recombination (GO:0045910)2.55061416
123microtubule nucleation (GO:0007020)2.54974904
124forebrain morphogenesis (GO:0048853)2.54920811
125gastrulation with mouth forming second (GO:0001702)2.53624923
126establishment of protein localization to mitochondrial membrane (GO:0090151)2.51731381
127mitotic chromosome condensation (GO:0007076)2.50858701
128protein localization to Golgi apparatus (GO:0034067)2.50664342
129smoothened signaling pathway (GO:0007224)2.50449083
130anterior/posterior axis specification, embryo (GO:0008595)2.50370807
131regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.47300335
132centrosome localization (GO:0051642)2.45279532
133lung-associated mesenchyme development (GO:0060484)2.44627999
134establishment of nucleus localization (GO:0040023)2.44599121
135resolution of meiotic recombination intermediates (GO:0000712)2.43224182
136metaphase plate congression (GO:0051310)2.42184490
137spindle assembly involved in mitosis (GO:0090307)2.36907721
138negative regulation of DNA-dependent DNA replication (GO:2000104)2.36266663
139regulation of histone H3-K9 methylation (GO:0051570)2.34362053
140negative regulation of cytosolic calcium ion concentration (GO:0051481)2.33243692
141sperm capacitation (GO:0048240)2.33184025
142regulation of helicase activity (GO:0051095)2.33116212
143regulation of non-canonical Wnt signaling pathway (GO:2000050)2.31606717
144Golgi to endosome transport (GO:0006895)2.31047542
145determination of left/right symmetry (GO:0007368)2.30972363
146histone exchange (GO:0043486)2.26592075
147genitalia morphogenesis (GO:0035112)2.25341112
148pyrimidine dimer repair (GO:0006290)2.25040156
149regulation of centrosome cycle (GO:0046605)2.23565263
150determination of bilateral symmetry (GO:0009855)2.23444135
151neuron cell-cell adhesion (GO:0007158)2.23254838
152neurofilament cytoskeleton organization (GO:0060052)2.22661857
153olfactory bulb development (GO:0021772)2.22400049
154regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.21372257
155chromatin remodeling at centromere (GO:0031055)2.21145553
156CENP-A containing nucleosome assembly (GO:0034080)2.19561610
157specification of symmetry (GO:0009799)2.18540817
158protein localization to synapse (GO:0035418)2.18173483
159nuclear pore organization (GO:0006999)2.16178109
160somite rostral/caudal axis specification (GO:0032525)2.15945391
161left/right pattern formation (GO:0060972)2.15251543

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.91522457
2EZH2_22144423_ChIP-Seq_EOC_Human3.82274586
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.59216796
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.78533908
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.71363162
6VDR_22108803_ChIP-Seq_LS180_Human2.63856837
7TAF15_26573619_Chip-Seq_HEK293_Human2.59775914
8GBX2_23144817_ChIP-Seq_PC3_Human2.30264773
9ZNF274_21170338_ChIP-Seq_K562_Hela2.22806643
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.17909868
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.14085752
12EWS_26573619_Chip-Seq_HEK293_Human2.12580062
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.08940960
14SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.05485402
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97975187
16FOXM1_23109430_ChIP-Seq_U2OS_Human1.91036716
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.86725426
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85502715
19IGF1R_20145208_ChIP-Seq_DFB_Human1.85142481
20GATA1_26923725_Chip-Seq_HPCs_Mouse1.84125901
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.83614843
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.78896444
23SALL1_21062744_ChIP-ChIP_HESCs_Human1.75262502
24MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.72564136
25RNF2_27304074_Chip-Seq_NSC_Mouse1.68589386
26HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.68501212
27SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64512783
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.60832701
29CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58966235
30POU5F1_16153702_ChIP-ChIP_HESCs_Human1.58917316
31OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57304226
32DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.56561862
33CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.56142455
34TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.55104672
35NANOG_18555785_Chip-Seq_ESCs_Mouse1.55076827
36POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.53202170
37TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53202170
38* SMAD4_21799915_ChIP-Seq_A2780_Human1.52175861
39* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.51955164
40ELK4_26923725_Chip-Seq_MESODERM_Mouse1.50801804
41FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.50776059
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48480478
43STAT3_23295773_ChIP-Seq_U87_Human1.47554257
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41856290
45REST_21632747_ChIP-Seq_MESCs_Mouse1.40947434
46* TCF4_23295773_ChIP-Seq_U87_Human1.40505583
47MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.40365118
48* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39063559
49IRF1_19129219_ChIP-ChIP_H3396_Human1.38462397
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35790014
51TBX3_20139965_ChIP-Seq_ESCs_Mouse1.29323737
52TBX3_20139965_ChIP-Seq_MESCs_Mouse1.28846771
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26154284
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.25904412
55TAL1_26923725_Chip-Seq_HPCs_Mouse1.24350442
56EP300_21415370_ChIP-Seq_HL-1_Mouse1.23467632
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22774966
58EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22608743
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22553472
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22098664
61STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.21768568
62* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20597843
63TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.20497877
64P300_19829295_ChIP-Seq_ESCs_Human1.20072256
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.19835294
66TP53_18474530_ChIP-ChIP_U2OS_Human1.17791531
67CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17666169
68* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16696739
69CMYC_18555785_Chip-Seq_ESCs_Mouse1.16617131
70KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16453123
71E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.15842353
72TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15758634
73RUNX1_26923725_Chip-Seq_HPCs_Mouse1.15451479
74SOX9_26525672_Chip-Seq_HEART_Mouse1.15244712
75KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15149746
76TCF4_22108803_ChIP-Seq_LS180_Human1.13246803
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13142689
78DROSHA_22980978_ChIP-Seq_HELA_Human1.12027560
79SOX2_16153702_ChIP-ChIP_HESCs_Human1.11936527
80KDM2B_26808549_Chip-Seq_REH_Human1.11807253
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11137092
82CBP_20019798_ChIP-Seq_JUKART_Human1.11137092
83SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10989006
84CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10648583
85SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10066687
86SMAD4_21741376_ChIP-Seq_EPCs_Human1.09844799
87WDR5_24793694_ChIP-Seq_LNCAP_Human1.09206024
88STAT3_18555785_Chip-Seq_ESCs_Mouse1.09041188
89SOX2_19829295_ChIP-Seq_ESCs_Human1.08956086
90NANOG_19829295_ChIP-Seq_ESCs_Human1.08956086
91* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08914115
92E2F1_18555785_Chip-Seq_ESCs_Mouse1.08641632
93NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07455033
94NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07064638
95SOX2_21211035_ChIP-Seq_LN229_Gbm1.06679139
96P53_22387025_ChIP-Seq_ESCs_Mouse1.06633475
97TBL1_22424771_ChIP-Seq_293T_Human1.06588585
98ARNT_22903824_ChIP-Seq_MCF-7_Human1.06329905
99ELK1_19687146_ChIP-ChIP_HELA_Human1.06150928
100BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05858430
101AR_21572438_ChIP-Seq_LNCaP_Human1.05842277
102STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05702184
103CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05594743
104NANOG_16153702_ChIP-ChIP_HESCs_Human1.04948286
105BCAT_22108803_ChIP-Seq_LS180_Human1.04198688
106TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03923984
107RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03672382
108JUN_21703547_ChIP-Seq_K562_Human1.03227450
109KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02628355
110AR_25329375_ChIP-Seq_VCAP_Human1.02203355
111ZFX_18555785_Chip-Seq_ESCs_Mouse1.02093446
112SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01939848
113FLI1_21867929_ChIP-Seq_TH2_Mouse1.01389702
114SMAD3_21741376_ChIP-Seq_EPCs_Human1.00867556
115NFE2_27457419_Chip-Seq_LIVER_Mouse1.00482631
116OCT4_18555785_Chip-Seq_ESCs_Mouse0.99995056
117* FUS_26573619_Chip-Seq_HEK293_Human0.99373838
118PIAS1_25552417_ChIP-Seq_VCAP_Human0.98897212
119P300_18555785_Chip-Seq_ESCs_Mouse0.97984247
120UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97970273
121KLF4_18555785_Chip-Seq_ESCs_Mouse0.97770931
122WT1_19549856_ChIP-ChIP_CCG9911_Human0.97258321
123EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.97092342
124PRDM14_20953172_ChIP-Seq_ESCs_Human0.96970014
125NMYC_18555785_Chip-Seq_ESCs_Mouse0.96880013
126* ER_23166858_ChIP-Seq_MCF-7_Human0.96837941
127SMAD3_21741376_ChIP-Seq_ESCs_Human0.96594994
128SOX2_18555785_Chip-Seq_ESCs_Mouse0.96240085
129GF1B_26923725_Chip-Seq_HPCs_Mouse0.96098725
130EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95748114
131TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95439228
132AHR_22903824_ChIP-Seq_MCF-7_Human0.95277347
133AR_19668381_ChIP-Seq_PC3_Human0.94935015
134TP53_16413492_ChIP-PET_HCT116_Human0.94846632
135CTCF_18555785_Chip-Seq_ESCs_Mouse0.93441468
136TP63_19390658_ChIP-ChIP_HaCaT_Human0.92067945
137SMAD3_21741376_ChIP-Seq_HESCs_Human0.91913558
138* RUNX2_22187159_ChIP-Seq_PCA_Human0.91563214
139YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91141599
140LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90950499

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation6.33252350
2MP0005551_abnormal_eye_electrophysiolog6.18895564
3MP0005253_abnormal_eye_physiology4.55870684
4MP0006072_abnormal_retinal_apoptosis4.42799378
5MP0005410_abnormal_fertilization4.32646345
6MP0008877_abnormal_DNA_methylation3.57144638
7MP0002638_abnormal_pupillary_reflex2.91918743
8MP0002653_abnormal_ependyma_morphology2.84205480
9MP0001984_abnormal_olfaction2.81303562
10MP0005195_abnormal_posterior_eye2.61467959
11MP0005391_vision/eye_phenotype2.51435607
12MP0003950_abnormal_plasma_membrane2.43886413
13MP0001929_abnormal_gametogenesis2.38763046
14MP0003698_abnormal_male_reproductive2.36069046
15MP0001324_abnormal_eye_pigmentation2.29884062
16MP0002233_abnormal_nose_morphology2.17929925
17MP0001299_abnormal_eye_distance/2.15907007
18MP0003880_abnormal_central_pattern1.99994363
19MP0001502_abnormal_circadian_rhythm1.95738245
20MP0003941_abnormal_skin_development1.94879187
21MP0008058_abnormal_DNA_repair1.83647456
22MP0006292_abnormal_olfactory_placode1.82613064
23MP0003787_abnormal_imprinting1.81884871
24MP0002210_abnormal_sex_determination1.80869337
25MP0002229_neurodegeneration1.79880812
26MP0000569_abnormal_digit_pigmentation1.79564217
27MP0005499_abnormal_olfactory_system1.75616393
28MP0005394_taste/olfaction_phenotype1.75616393
29MP0003937_abnormal_limbs/digits/tail_de1.70066321
30MP0002752_abnormal_somatic_nervous1.68305951
31MP0003890_abnormal_embryonic-extraembry1.56631476
32MP0003121_genomic_imprinting1.50448580
33MP0003119_abnormal_digestive_system1.49919608
34MP0010094_abnormal_chromosome_stability1.48311968
35MP0003183_abnormal_peptide_metabolism1.45757412
36MP0002102_abnormal_ear_morphology1.43497603
37MP0005646_abnormal_pituitary_gland1.42363816
38MP0005187_abnormal_penis_morphology1.42107957
39MP0004233_abnormal_muscle_weight1.40823414
40MP0002277_abnormal_respiratory_mucosa1.40560845
41MP0005423_abnormal_somatic_nervous1.39533544
42MP0002090_abnormal_vision1.39374889
43MP0001145_abnormal_male_reproductive1.39292574
44MP0002161_abnormal_fertility/fecundity1.38319486
45MP0000653_abnormal_sex_gland1.37681801
46MP0002697_abnormal_eye_size1.35303092
47MP0005248_abnormal_Harderian_gland1.33164979
48MP0002882_abnormal_neuron_morphology1.30284255
49MP0008057_abnormal_DNA_replication1.29121599
50MP0002938_white_spotting1.28141076
51MP0003938_abnormal_ear_development1.27650787
52MP0002751_abnormal_autonomic_nervous1.26128250
53MP0008995_early_reproductive_senescence1.26038858
54MP0009384_cardiac_valve_regurgitation1.25186756
55MP0002254_reproductive_system_inflammat1.22412283
56MP0001188_hyperpigmentation1.22321914
57MP0001986_abnormal_taste_sensitivity1.22314086
58MP0008789_abnormal_olfactory_epithelium1.20808178
59MP0000049_abnormal_middle_ear1.19540989
60MP0001485_abnormal_pinna_reflex1.14844704
61MP0002084_abnormal_developmental_patter1.11126827
62MP0003755_abnormal_palate_morphology1.10170873
63MP0000428_abnormal_craniofacial_morphol1.09567699
64MP0003122_maternal_imprinting1.09541887
65MP0000566_synostosis1.09048914
66MP0002822_catalepsy1.08762962
67MP0004270_analgesia1.07199753
68MP0000647_abnormal_sebaceous_gland1.07092789
69MP0004215_abnormal_myocardial_fiber1.06879926
70MP0005395_other_phenotype1.03837496
71MP0008007_abnormal_cellular_replicative1.01912598
72MP0005623_abnormal_meninges_morphology0.99452539
73MP0000631_abnormal_neuroendocrine_gland0.96722708
74MP0002160_abnormal_reproductive_system0.96394691
75MP0000427_abnormal_hair_cycle0.95808915
76MP0009250_abnormal_appendicular_skeleto0.94450182
77MP0002282_abnormal_trachea_morphology0.94369423
78MP0003935_abnormal_craniofacial_develop0.94075748
79MP0001346_abnormal_lacrimal_gland0.93436908
80MP0009046_muscle_twitch0.93206604
81MP0002234_abnormal_pharynx_morphology0.93002152
82MP0002085_abnormal_embryonic_tissue0.92829410
83MP0001486_abnormal_startle_reflex0.92366718
84MP0001293_anophthalmia0.91409096
85MP0003111_abnormal_nucleus_morphology0.88763897
86MP0001529_abnormal_vocalization0.88235158
87MP0002272_abnormal_nervous_system0.85200141
88MP0002734_abnormal_mechanical_nocicepti0.84752295
89MP0000383_abnormal_hair_follicle0.83574722
90MP0002557_abnormal_social/conspecific_i0.82452388
91MP0001879_abnormal_lymphatic_vessel0.80728846
92MP0003077_abnormal_cell_cycle0.79346770
93MP0010030_abnormal_orbit_morphology0.77952635
94MP0003634_abnormal_glial_cell0.77679744
95MP0006276_abnormal_autonomic_nervous0.76801157
96MP0003567_abnormal_fetal_cardiomyocyte0.76489109
97MP0000778_abnormal_nervous_system0.76014863
98MP0010368_abnormal_lymphatic_system0.75974211
99MP0004084_abnormal_cardiac_muscle0.75960116
100MP0002572_abnormal_emotion/affect_behav0.75862248
101MP0000432_abnormal_head_morphology0.75843022
102MP0004085_abnormal_heartbeat0.75549559
103MP0004957_abnormal_blastocyst_morpholog0.75490158
104MP0000026_abnormal_inner_ear0.74344208
105MP0000015_abnormal_ear_pigmentation0.73721747
106MP0005377_hearing/vestibular/ear_phenot0.72040984
107MP0003878_abnormal_ear_physiology0.72040984
108MP0003045_fibrosis0.70819234
109MP0001119_abnormal_female_reproductive0.69612642
110MP0001286_abnormal_eye_development0.68943838
111MP0000372_irregular_coat_pigmentation0.68682276
112MP0004264_abnormal_extraembryonic_tissu0.66124643
113MP0002063_abnormal_learning/memory/cond0.64811645
114MP0004142_abnormal_muscle_tone0.64758918
115MP0002184_abnormal_innervation0.64598030
116MP0003786_premature_aging0.64055435
117MP0003861_abnormal_nervous_system0.63195360
118MP0003699_abnormal_female_reproductive0.63082442
119MP0002152_abnormal_brain_morphology0.62963398
120MP0002067_abnormal_sensory_capabilities0.61456943
121MP0001963_abnormal_hearing_physiology0.59815042
122MP0010386_abnormal_urinary_bladder0.59152354
123MP0004133_heterotaxia0.58959515
124MP0005645_abnormal_hypothalamus_physiol0.58681056
125MP0002064_seizures0.58393508
126MP0001968_abnormal_touch/_nociception0.58212553
127MP0003136_yellow_coat_color0.57785067
128MP0003635_abnormal_synaptic_transmissio0.57019101
129MP0004742_abnormal_vestibular_system0.53994370
130MP0001851_eye_inflammation0.52774701
131MP0005076_abnormal_cell_differentiation0.52663604
132MP0002127_abnormal_cardiovascular_syste0.52470074
133MP0005075_abnormal_melanosome_morpholog0.51811061
134MP0002928_abnormal_bile_duct0.51234888
135MP0000955_abnormal_spinal_cord0.50648507
136MP0002092_abnormal_eye_morphology0.49191891
137MP0005389_reproductive_system_phenotype0.47947946
138MP0009703_decreased_birth_body0.47004657
139MP0005197_abnormal_uvea_morphology0.46945508
140MP0004811_abnormal_neuron_physiology0.46873931
141MP0008569_lethality_at_weaning0.46194999
142MP0005171_absent_coat_pigmentation0.46075976
143MP0003718_maternal_effect0.45225829
144MP0003646_muscle_fatigue0.44313720

Predicted human phenotypes

RankGene SetZ-score
1Bony spicule pigmentary retinopathy (HP:0007737)8.25201755
2Congenital stationary night blindness (HP:0007642)7.59899826
3Dyschromatopsia (HP:0007641)6.32899508
4Abnormal rod and cone electroretinograms (HP:0008323)6.23516198
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.10932423
6Central scotoma (HP:0000603)6.03321799
7Abnormality of macular pigmentation (HP:0008002)5.84136092
8Absent rod-and cone-mediated responses on ERG (HP:0007688)5.80174873
9Scotoma (HP:0000575)5.40492859
10Septo-optic dysplasia (HP:0100842)5.26593846
11Abolished electroretinogram (ERG) (HP:0000550)5.08781542
12Chorioretinal atrophy (HP:0000533)4.93702185
13Pendular nystagmus (HP:0012043)4.87504492
14Attenuation of retinal blood vessels (HP:0007843)4.53373929
15Absent/shortened dynein arms (HP:0200106)4.51334498
16Dynein arm defect of respiratory motile cilia (HP:0012255)4.51334498
17Decreased central vision (HP:0007663)4.47882602
18Pigmentary retinal degeneration (HP:0001146)4.45738628
19Abnormal respiratory motile cilium physiology (HP:0012261)4.28862067
20Type II diabetes mellitus (HP:0005978)4.11151957
21Cone-rod dystrophy (HP:0000548)3.93687416
22Photophobia (HP:0000613)3.81496069
23Macular degeneration (HP:0000608)3.64687494
24Chronic bronchitis (HP:0004469)3.60323480
25Rhinitis (HP:0012384)3.59979864
26* Retinitis pigmentosa (HP:0000510)3.52545454
27Abnormal ciliary motility (HP:0012262)3.37216614
28Severe visual impairment (HP:0001141)3.35145718
29Abnormal respiratory epithelium morphology (HP:0012253)3.34070689
30Abnormal respiratory motile cilium morphology (HP:0005938)3.34070689
31Absent septum pellucidum (HP:0001331)3.29209909
32Choroideremia (HP:0001139)3.28877584
33Constricted visual fields (HP:0001133)3.25659419
34Abnormality of the septum pellucidum (HP:0007375)3.21067825
35* Medial flaring of the eyebrow (HP:0010747)3.15408584
36Molar tooth sign on MRI (HP:0002419)3.08616751
37Abnormality of midbrain morphology (HP:0002418)3.08616751
38Optic nerve hypoplasia (HP:0000609)3.06848619
39Supernumerary spleens (HP:0009799)3.05967532
40Keratoconus (HP:0000563)3.05696874
41Increased corneal curvature (HP:0100692)3.05696874
42* Gait imbalance (HP:0002141)2.98813758
43Posterior subcapsular cataract (HP:0007787)2.97497594
44Nephronophthisis (HP:0000090)2.95938859
45* Congenital primary aphakia (HP:0007707)2.95497843
46Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.91909610
47Colon cancer (HP:0003003)2.89615070
48Vitreoretinal degeneration (HP:0000655)2.86783703
49Maternal diabetes (HP:0009800)2.86430866
50Abnormality of the labia minora (HP:0012880)2.83910651
51* Nephrogenic diabetes insipidus (HP:0009806)2.77050868
52Tubulointerstitial nephritis (HP:0001970)2.65546853
53Pancreatic fibrosis (HP:0100732)2.64675549
54True hermaphroditism (HP:0010459)2.64551484
55Gonadotropin excess (HP:0000837)2.50577980
56Median cleft lip (HP:0000161)2.42339340
57Subcapsular cataract (HP:0000523)2.41220377
58Infertility (HP:0000789)2.40401313
59Impulsivity (HP:0100710)2.35627031
60Bile duct proliferation (HP:0001408)2.35587310
61Abnormal biliary tract physiology (HP:0012439)2.35587310
62Neoplasm of the adrenal cortex (HP:0100641)2.35557148
63Retinal atrophy (HP:0001105)2.34403564
64Abnormality of the renal medulla (HP:0100957)2.32162378
65* Poor coordination (HP:0002370)2.29180557
66Growth hormone deficiency (HP:0000824)2.26738259
67Bronchiectasis (HP:0002110)2.24567957
68Papillary thyroid carcinoma (HP:0002895)2.24430813
69Anophthalmia (HP:0000528)2.21850416
70Absent eyebrow (HP:0002223)2.21409429
71Stenosis of the external auditory canal (HP:0000402)2.19769542
72Chromsome breakage (HP:0040012)2.18581314
73Aplasia/Hypoplasia of the tibia (HP:0005772)2.16336922
74Chromosomal breakage induced by crosslinking agents (HP:0003221)2.16263194
75Decreased electroretinogram (ERG) amplitude (HP:0000654)2.15812403
76Congenital sensorineural hearing impairment (HP:0008527)2.15314233
77Hepatoblastoma (HP:0002884)2.11458258
78Pancreatic cysts (HP:0001737)2.09082115
79Short tibia (HP:0005736)2.07878997
80Intestinal atresia (HP:0011100)2.04180861
81Postaxial foot polydactyly (HP:0001830)2.04148275
82Aplasia/Hypoplasia of the tongue (HP:0010295)2.01249934
83Cystic liver disease (HP:0006706)2.00785322
84Progressive visual loss (HP:0000529)2.00610968
85Abnormality of the renal cortex (HP:0011035)1.98109647
86* Aplasia/Hypoplasia of the lens (HP:0008063)1.96557633
87Cortical dysplasia (HP:0002539)1.95870679
88Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.95841813
89Hyperglycinemia (HP:0002154)1.95562107
90Bell-shaped thorax (HP:0001591)1.94959676
91* Genital tract atresia (HP:0001827)1.94112883
92Abnormal pancreas size (HP:0012094)1.94082063
93Wide nasal bridge (HP:0000431)1.93459891
94* Vaginal atresia (HP:0000148)1.93277412
95* Postaxial hand polydactyly (HP:0001162)1.91213068
96Abnormality of the fovea (HP:0000493)1.89493896
97Gastrointestinal atresia (HP:0002589)1.84005936
98Tubular atrophy (HP:0000092)1.83073156
99* Broad foot (HP:0001769)1.81870563
100* Astigmatism (HP:0000483)1.80817060
101Bronchitis (HP:0012387)1.78970377
102Osteomalacia (HP:0002749)1.77915791
103Renal dysplasia (HP:0000110)1.77631127
104Abnormal hair whorl (HP:0010721)1.76532813
105Congenital hepatic fibrosis (HP:0002612)1.76478098
106Nasal polyposis (HP:0100582)1.76357854
107Aplasia/Hypoplasia of the uvula (HP:0010293)1.74921997
108Heterotopia (HP:0002282)1.74851147
109Occipital encephalocele (HP:0002085)1.74757218
110Male infertility (HP:0003251)1.71670955
111Recurrent otitis media (HP:0000403)1.69458534
112Oligodactyly (hands) (HP:0001180)1.68846932
113Abnormality of the lower motor neuron (HP:0002366)1.68243377
114Nephroblastoma (Wilms tumor) (HP:0002667)1.65169720
115Aqueductal stenosis (HP:0002410)1.64826669
116Preaxial foot polydactyly (HP:0001841)1.63821029
117Recurrent sinusitis (HP:0011108)1.63816879
118Male pseudohermaphroditism (HP:0000037)1.63760086
119Oculomotor apraxia (HP:0000657)1.63252645
120Labial hypoplasia (HP:0000066)1.63082577
121Abnormality of chromosome segregation (HP:0002916)1.62040951
122Abnormal lung lobation (HP:0002101)1.60010096
123Tubulointerstitial abnormality (HP:0001969)1.59711445
124Embryonal renal neoplasm (HP:0011794)1.59080151
125Renal cortical cysts (HP:0000803)1.58874731
126Febrile seizures (HP:0002373)1.57876941
127Preaxial hand polydactyly (HP:0001177)1.57150971
128Anencephaly (HP:0002323)1.56100686
129Aplasia/Hypoplasia of the fovea (HP:0008060)1.55207337
130Hypoplasia of the fovea (HP:0007750)1.55207337
131* Multicystic kidney dysplasia (HP:0000003)1.53672966
132Aplasia/Hypoplasia affecting the retina (HP:0008061)1.52764049
133Dandy-Walker malformation (HP:0001305)1.52512994
134Aplasia/Hypoplasia of the macula (HP:0008059)1.51630234
135Hypoplastic female external genitalia (HP:0012815)1.51392531
136Gaze-evoked nystagmus (HP:0000640)1.50186379
137Omphalocele (HP:0001539)1.50134240
138Cutaneous finger syndactyly (HP:0010554)1.50059494
139Chronic hepatic failure (HP:0100626)1.49921339
140* Micropenis (HP:0000054)1.49761875
141Abnormality of the ileum (HP:0001549)1.49545170
142Tented upper lip vermilion (HP:0010804)1.48997621
143Sclerocornea (HP:0000647)1.48012215
144* Prominent nasal bridge (HP:0000426)1.46958018
145Bifid tongue (HP:0010297)1.46293091
146* Aganglionic megacolon (HP:0002251)1.45814588
147* Specific learning disability (HP:0001328)1.45488941
148Facial cleft (HP:0002006)1.45255881
149Sloping forehead (HP:0000340)1.45209414
150Renal hypoplasia (HP:0000089)1.44666183
151Meckel diverticulum (HP:0002245)1.44568520
152Abnormality of chromosome stability (HP:0003220)1.44198927
153Intellectual disability, moderate (HP:0002342)1.43415174
154Narrow forehead (HP:0000341)1.43350684
155Neoplasm of the adrenal gland (HP:0100631)1.42558090
156Fibular hypoplasia (HP:0003038)1.40906647

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK14.65006432
2PDK43.08288580
3PDK33.08288580
4ICK2.90060281
5PRKD32.88396679
6NTRK22.64466391
7TIE12.52538530
8WNK32.48827099
9MAP4K22.47812497
10NUAK12.38712975
11CASK2.36311622
12ZAK2.35194968
13CDK122.32289983
14PDK22.18289634
15CDC72.03333681
16NEK21.89932479
17CDK191.86043571
18TRIM281.86020851
19MST41.74003047
20TSSK61.72602619
21TAF11.71532957
22BRD41.69839105
23STK381.55140116
24PBK1.53603469
25STK161.53031946
26CDK31.52819585
27MAP3K41.52231718
28SGK21.50326290
29CSNK1G11.49961903
30SGK4941.49478355
31SGK2231.49478355
32TTK1.48346603
33TYRO31.46096996
34FRK1.45665782
35EEF2K1.44177395
36MAPK131.43977819
37MUSK1.42020657
38MKNK11.37655090
39CCNB11.35740996
40MAPK151.34963228
41MAP3K61.34859792
42ACVR1B1.29572006
43CAMK1G1.28345700
44CAMK1D1.28101209
45ERBB41.20993170
46IRAK21.20599362
47MAP2K71.20125503
48CSNK1A1L1.15489752
49MAP3K91.11839112
50DYRK21.06774271
51PLK21.06218362
52ERBB31.05831549
53CSNK1G31.05785585
54TAOK31.04650099
55PINK11.03955979
56CHEK21.01992980
57WNK11.00851009
58LATS11.00079613
59STK240.98970177
60VRK10.97393185
61SGK30.95708821
62CDK90.95381150
63YES10.91073096
64NLK0.90591654
65STK390.88712054
66MARK20.87404873
67SIK30.85948920
68HIPK20.85678517
69PLK10.85285651
70GRK70.84448284
71TAOK10.84247638
72EPHA40.84069063
73MKNK20.82501475
74OXSR10.82056394
75CHEK10.80775766
76DYRK1A0.79926313
77PAK30.78968924
78BCKDK0.78769867
79MET0.78327183
80ATR0.77293346
81DMPK0.77088897
82TNIK0.76786506
83MAPK70.76729876
84STK100.73361582
85PRKAA10.71278515
86TAOK20.70592666
87PRKCG0.70013405
88NTRK30.69736350
89EPHA30.69214059
90PNCK0.68557558
91BUB10.68401476
92PLK40.67947596
93ADRBK20.67164848
94STK38L0.67099546
95PRKCE0.65725040
96ERBB20.65644811
97BMPR20.65458036
98WNK40.65177146
99MELK0.63081304
100ATM0.60904022
101CAMK40.60207354
102ADRBK10.59965392
103STK40.59329779
104KSR10.59036635
105FGFR20.58820996
106AKT30.58417391
107NEK60.58413011
108OBSCN0.57645701
109FGFR10.56749025
110IRAK10.54997307
111DYRK1B0.54251673
112BMPR1B0.53767690
113BCR0.53487348
114CAMK2A0.52348201
115PLK30.52264145
116PIK3CA0.52260507
117EGFR0.51535476
118SRPK10.51456647
119CDK10.51107280
120AURKA0.50653801
121MAPKAPK50.50381977
122CSNK1D0.49898812
123TGFBR10.49695105
124PRKACB0.49436066
125FGFR30.48854689
126CDK70.48433815
127CHUK0.48099020
128GSK3B0.45435670
129CSNK1G20.44691614
130BRSK20.44641242
131PRKG10.44440935
132CSNK1E0.44339797
133STK30.43920313
134BRAF0.43857609
135MINK10.42074919
136MARK10.41509959
137MARK30.41294985
138MAPK100.41221885
139MAP3K120.41059748
140TXK0.40705946
141DYRK30.40703772
142PDGFRB0.40226338
143PRKD20.39871281
144RPS6KB10.39568306
145GRK50.38782828
146NEK90.38304281
147AURKB0.37848080
148INSRR0.37468637
149PRPF4B0.36275877
150MAPK140.35663586
151CSF1R0.33546015
152WEE10.33526367

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.55273860
2Olfactory transduction_Homo sapiens_hsa047402.47184991
3Propanoate metabolism_Homo sapiens_hsa006402.04879899
4Phototransduction_Homo sapiens_hsa0474410.1989607
5Protein export_Homo sapiens_hsa030601.95574323
6Fanconi anemia pathway_Homo sapiens_hsa034601.86372880
7Synaptic vesicle cycle_Homo sapiens_hsa047211.73559856
8Huntingtons disease_Homo sapiens_hsa050161.70706640
9Mismatch repair_Homo sapiens_hsa034301.68069804
10Basal cell carcinoma_Homo sapiens_hsa052171.63125748
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61246683
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.52913544
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.49784583
14Non-homologous end-joining_Homo sapiens_hsa034501.43013999
15Circadian rhythm_Homo sapiens_hsa047101.41072291
16Tight junction_Homo sapiens_hsa045301.40230486
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36488977
18RNA transport_Homo sapiens_hsa030131.34713981
19Morphine addiction_Homo sapiens_hsa050321.33986295
20TGF-beta signaling pathway_Homo sapiens_hsa043501.33568032
21Caffeine metabolism_Homo sapiens_hsa002321.32737924
22Adherens junction_Homo sapiens_hsa045201.26756478
23Basal transcription factors_Homo sapiens_hsa030221.26660060
24Steroid biosynthesis_Homo sapiens_hsa001001.25762522
25RNA polymerase_Homo sapiens_hsa030201.24853898
26Selenocompound metabolism_Homo sapiens_hsa004501.23356213
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.22628592
28Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.21685236
29Cardiac muscle contraction_Homo sapiens_hsa042601.21011854
30Vitamin B6 metabolism_Homo sapiens_hsa007501.20417739
31Oocyte meiosis_Homo sapiens_hsa041141.20226386
32p53 signaling pathway_Homo sapiens_hsa041151.18672971
33Insulin secretion_Homo sapiens_hsa049111.18418170
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17827966
35Dopaminergic synapse_Homo sapiens_hsa047281.16148768
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.15408548
37Circadian entrainment_Homo sapiens_hsa047131.14002445
38Fatty acid elongation_Homo sapiens_hsa000621.12063467
39Cholinergic synapse_Homo sapiens_hsa047251.08664932
40GABAergic synapse_Homo sapiens_hsa047271.05647538
41Inositol phosphate metabolism_Homo sapiens_hsa005621.05593037
42Homologous recombination_Homo sapiens_hsa034401.02261262
43mRNA surveillance pathway_Homo sapiens_hsa030151.02222873
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01660811
45Parkinsons disease_Homo sapiens_hsa050121.01608407
46Cell cycle_Homo sapiens_hsa041101.01071688
47Amphetamine addiction_Homo sapiens_hsa050311.00616681
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99985049
49Glutamatergic synapse_Homo sapiens_hsa047240.99943515
50Nucleotide excision repair_Homo sapiens_hsa034200.99747709
51Alcoholism_Homo sapiens_hsa050340.99538437
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98618605
53Cocaine addiction_Homo sapiens_hsa050300.97931223
54Dorso-ventral axis formation_Homo sapiens_hsa043200.96741423
55Nicotine addiction_Homo sapiens_hsa050330.96342430
56RNA degradation_Homo sapiens_hsa030180.96046920
57Purine metabolism_Homo sapiens_hsa002300.95501211
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.94725257
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94686118
60Oxidative phosphorylation_Homo sapiens_hsa001900.94586917
61Serotonergic synapse_Homo sapiens_hsa047260.94016981
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.93313198
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92964410
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92774927
65cAMP signaling pathway_Homo sapiens_hsa040240.91837177
66Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.90266447
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88747351
68Butanoate metabolism_Homo sapiens_hsa006500.88537605
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.87855562
70Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.87641350
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87509228
72Peroxisome_Homo sapiens_hsa041460.87404259
73Ovarian steroidogenesis_Homo sapiens_hsa049130.85915404
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82784371
75Renin secretion_Homo sapiens_hsa049240.81524804
76Regulation of autophagy_Homo sapiens_hsa041400.80286862
77ECM-receptor interaction_Homo sapiens_hsa045120.79547937
78Base excision repair_Homo sapiens_hsa034100.78075418
79Gap junction_Homo sapiens_hsa045400.76752737
80beta-Alanine metabolism_Homo sapiens_hsa004100.76223267
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75517416
82Long-term depression_Homo sapiens_hsa047300.74746652
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.74219884
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74197495
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.74107573
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73646711
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73251924
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72807786
89Taste transduction_Homo sapiens_hsa047420.71688692
90Ether lipid metabolism_Homo sapiens_hsa005650.71235850
91Long-term potentiation_Homo sapiens_hsa047200.70699292
92Melanogenesis_Homo sapiens_hsa049160.69708449
93Glucagon signaling pathway_Homo sapiens_hsa049220.68819273
94Dilated cardiomyopathy_Homo sapiens_hsa054140.67188296
95Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66972837
96Pyruvate metabolism_Homo sapiens_hsa006200.66829220
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66775418
98Oxytocin signaling pathway_Homo sapiens_hsa049210.65925395
99Lysine degradation_Homo sapiens_hsa003100.64351508
100Colorectal cancer_Homo sapiens_hsa052100.62247405
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61707500
102Alzheimers disease_Homo sapiens_hsa050100.61261425
103Notch signaling pathway_Homo sapiens_hsa043300.60302011
104Linoleic acid metabolism_Homo sapiens_hsa005910.60118464
105Wnt signaling pathway_Homo sapiens_hsa043100.59767326
106Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57731206
107Fatty acid biosynthesis_Homo sapiens_hsa000610.57650871
108Calcium signaling pathway_Homo sapiens_hsa040200.57012783
109Melanoma_Homo sapiens_hsa052180.56749026
110GnRH signaling pathway_Homo sapiens_hsa049120.55151945
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54547034
112Salivary secretion_Homo sapiens_hsa049700.54427354
113Pancreatic cancer_Homo sapiens_hsa052120.53684354
114Choline metabolism in cancer_Homo sapiens_hsa052310.52329417
115Chemical carcinogenesis_Homo sapiens_hsa052040.52199533
116T cell receptor signaling pathway_Homo sapiens_hsa046600.52084442
117Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51862374
118ABC transporters_Homo sapiens_hsa020100.51437434
119Ras signaling pathway_Homo sapiens_hsa040140.50558188
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50384690
121Estrogen signaling pathway_Homo sapiens_hsa049150.50326610
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50320646
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.50092743
124Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49038122
125mTOR signaling pathway_Homo sapiens_hsa041500.48810559
126Hedgehog signaling pathway_Homo sapiens_hsa043400.48763491
127B cell receptor signaling pathway_Homo sapiens_hsa046620.48276846
128Collecting duct acid secretion_Homo sapiens_hsa049660.48218974
129Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47581060
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.46442789
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46076458
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45627220
133Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45027487
134Vibrio cholerae infection_Homo sapiens_hsa051100.44588109
135Pathways in cancer_Homo sapiens_hsa052000.43897395
136Glutathione metabolism_Homo sapiens_hsa004800.42707680
137Thyroid hormone synthesis_Homo sapiens_hsa049180.42658859
138Vascular smooth muscle contraction_Homo sapiens_hsa042700.42327787
139Rap1 signaling pathway_Homo sapiens_hsa040150.42107988
140Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42038298
141Non-small cell lung cancer_Homo sapiens_hsa052230.41274927
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41210706
143MAPK signaling pathway_Homo sapiens_hsa040100.41087637
144Axon guidance_Homo sapiens_hsa043600.41085434
145Neurotrophin signaling pathway_Homo sapiens_hsa047220.40850796
146Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40622465
147Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39324339
148Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39190255
149Gastric acid secretion_Homo sapiens_hsa049710.38903570
150Sphingolipid signaling pathway_Homo sapiens_hsa040710.38877441
151Endometrial cancer_Homo sapiens_hsa052130.38450439
152Hippo signaling pathway_Homo sapiens_hsa043900.38363132
153Renal cell carcinoma_Homo sapiens_hsa052110.38325085
154Sphingolipid metabolism_Homo sapiens_hsa006000.38257295
155MicroRNAs in cancer_Homo sapiens_hsa052060.38060382
156Systemic lupus erythematosus_Homo sapiens_hsa053220.37926768

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