BCAN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1astrocyte differentiation (GO:0048708)6.38652421
2locomotory exploration behavior (GO:0035641)6.21440467
3melanin biosynthetic process (GO:0042438)5.81799957
4eye photoreceptor cell differentiation (GO:0001754)5.57419190
5photoreceptor cell differentiation (GO:0046530)5.57419190
6L-amino acid import (GO:0043092)5.55373717
7presynaptic membrane organization (GO:0097090)5.54902815
8enteric nervous system development (GO:0048484)5.54386857
9melanin metabolic process (GO:0006582)5.27470553
10* dermatan sulfate biosynthetic process (GO:0030208)5.27353036
11amino acid import (GO:0043090)5.16991624
12alanine transport (GO:0032328)5.05748621
13secondary metabolite biosynthetic process (GO:0044550)4.97336640
14* dermatan sulfate metabolic process (GO:0030205)4.93347217
15cellular potassium ion homeostasis (GO:0030007)4.83803500
16neurotransmitter-gated ion channel clustering (GO:0072578)4.83436427
17cGMP-mediated signaling (GO:0019934)4.79885965
18sodium ion export (GO:0071436)4.71429008
19synaptic vesicle maturation (GO:0016188)4.54253424
20C4-dicarboxylate transport (GO:0015740)4.53957491
21nephron tubule formation (GO:0072079)4.53456798
22gamma-aminobutyric acid transport (GO:0015812)4.50602896
23regulation of short-term neuronal synaptic plasticity (GO:0048172)4.47760849
24neuron projection regeneration (GO:0031102)4.41073081
25* chondroitin sulfate catabolic process (GO:0030207)4.36334648
26glial cell differentiation (GO:0010001)4.33636538
27astrocyte development (GO:0014002)4.33525045
28positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.32083134
29negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.25832463
30neuron cell-cell adhesion (GO:0007158)4.15994100
31vocalization behavior (GO:0071625)4.13885552
32regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.12445207
33response to auditory stimulus (GO:0010996)4.09891100
34positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.08133778
35exploration behavior (GO:0035640)4.07468787
36glial cell proliferation (GO:0014009)3.99429195
37cell communication by electrical coupling (GO:0010644)3.99382479
38ionotropic glutamate receptor signaling pathway (GO:0035235)3.95290655
39negative regulation of astrocyte differentiation (GO:0048712)3.91741024
40glutamate secretion (GO:0014047)3.89453986
41transmission of nerve impulse (GO:0019226)3.86318436
42layer formation in cerebral cortex (GO:0021819)3.85197076
43synaptic vesicle exocytosis (GO:0016079)3.82592864
44regulation of synapse structural plasticity (GO:0051823)3.80969162
45positive regulation of osteoblast proliferation (GO:0033690)3.79657543
46proline transport (GO:0015824)3.77686303
47positive regulation of gliogenesis (GO:0014015)3.77132419
48auditory behavior (GO:0031223)3.75948218
49regulation of glutamate receptor signaling pathway (GO:1900449)3.74749488
50regulation of neuronal synaptic plasticity (GO:0048168)3.70406946
51positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.70283390
52axon ensheathment in central nervous system (GO:0032291)3.68722326
53central nervous system myelination (GO:0022010)3.68722326
54regulation of beta-amyloid formation (GO:1902003)3.68396467
55cellular response to cholesterol (GO:0071397)3.66697612
56synaptic transmission, glutamatergic (GO:0035249)3.65266074
57L-serine transport (GO:0015825)3.64444753
58glutamate receptor signaling pathway (GO:0007215)3.63868641
59axon regeneration (GO:0031103)3.62966658
60potassium ion import (GO:0010107)3.62511952
61cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.61490062
62regulation of neurotransmitter uptake (GO:0051580)3.59482807
63membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.56973412
64neuronal action potential propagation (GO:0019227)3.56742314
65response to dietary excess (GO:0002021)3.55424878
66regulation of synaptic vesicle exocytosis (GO:2000300)3.54085731
67cellular sodium ion homeostasis (GO:0006883)3.52275880
68positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.51531224
69positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.49963695
70regulation of inclusion body assembly (GO:0090083)3.49233805
71neurotransmitter secretion (GO:0007269)3.48741528
72peripheral nervous system development (GO:0007422)3.48350457
73regulation of long-term neuronal synaptic plasticity (GO:0048169)3.46873154
74positive regulation of oligodendrocyte differentiation (GO:0048714)3.46619410
75regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.44395980
76acidic amino acid transport (GO:0015800)3.42768826
77cerebellar Purkinje cell layer development (GO:0021680)3.41581978
78regulation of synaptic transmission, glutamatergic (GO:0051966)3.39916508
79synaptic vesicle docking involved in exocytosis (GO:0016081)3.38144381
80negative regulation of sodium ion transport (GO:0010766)3.37128921
81G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.34801098
82regulation of respiratory system process (GO:0044065)3.33859864
83potassium ion homeostasis (GO:0055075)3.29543526
84membrane assembly (GO:0071709)3.29095139
85axon development (GO:0061564)3.28861751
86protein localization to synapse (GO:0035418)3.26946414
87hyperosmotic salinity response (GO:0042538)3.25976799
88neuromuscular process controlling balance (GO:0050885)3.24758218
89long-term memory (GO:0007616)3.23513917
90dendrite morphogenesis (GO:0048813)3.23410148
91one-carbon compound transport (GO:0019755)3.23376793
92regulation of amyloid precursor protein catabolic process (GO:1902991)3.22855647
93dendritic spine morphogenesis (GO:0060997)3.22607450
94postsynaptic membrane organization (GO:0001941)3.22383897
95heart valve formation (GO:0003188)3.20770353
96positive regulation of cellular amide metabolic process (GO:0034250)3.20279037
97negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.19910767
98neuronal ion channel clustering (GO:0045161)3.19766225
99Sertoli cell development (GO:0060009)3.18765213
100negative regulation of myoblast differentiation (GO:0045662)3.17867829
101long-term synaptic potentiation (GO:0060291)3.15892908
102regulation of phospholipid biosynthetic process (GO:0071071)3.12895953
103L-glutamate transport (GO:0015813)3.12743628
104negative regulation of neurotransmitter transport (GO:0051589)3.12125377
105regulation of synaptic vesicle transport (GO:1902803)3.11325108
106neuron-neuron synaptic transmission (GO:0007270)3.10303970
107positive regulation of neuroblast proliferation (GO:0002052)3.09940900
108peripheral nervous system axon ensheathment (GO:0032292)3.09462425
109myelination in peripheral nervous system (GO:0022011)3.09462425
110serine transport (GO:0032329)3.08585822
111cranial nerve development (GO:0021545)3.08317399
112regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.07723484
113positive regulation of potassium ion transmembrane transport (GO:1901381)3.07529375
114cerebellar granule cell differentiation (GO:0021707)3.07267114
115myelination (GO:0042552)3.04003749
116glycine transport (GO:0015816)3.02968945
117prepulse inhibition (GO:0060134)3.01756642
118endocardial cushion morphogenesis (GO:0003203)3.01051725
119neuronal stem cell maintenance (GO:0097150)2.99672402
120regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.99621328
121regulation of synaptic plasticity (GO:0048167)2.98923059
122cellular response to sterol (GO:0036315)2.97360779
123positive regulation of synaptic transmission, GABAergic (GO:0032230)2.96220859
124ensheathment of neurons (GO:0007272)2.95180532
125axon ensheathment (GO:0008366)2.95180532
126developmental induction (GO:0031128)2.94338015
127ovulation cycle (GO:0042698)2.93748074
128regulation of cholesterol biosynthetic process (GO:0045540)2.93456586
129membrane repolarization (GO:0086009)2.93256758
130neurotransmitter uptake (GO:0001504)2.93031883
131regulation of dendritic spine morphogenesis (GO:0061001)2.92453915
132cell-cell signaling involved in cell fate commitment (GO:0045168)2.92112283
133negative regulation of synaptic transmission, GABAergic (GO:0032229)2.91288611
134positive regulation of dendritic spine development (GO:0060999)2.90919989
135peptidyl-tyrosine autophosphorylation (GO:0038083)2.90291277
136neurotransmitter transport (GO:0006836)2.89949489
137regulation of gliogenesis (GO:0014013)2.88129968
138Notch signaling involved in heart development (GO:0061314)2.87719500
139cyclic-nucleotide-mediated signaling (GO:0019935)2.85441626
140regulation of astrocyte differentiation (GO:0048710)2.83014561
141regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.81655629
142negative regulation of oligodendrocyte differentiation (GO:0048715)2.81637109
143regulation of oligodendrocyte differentiation (GO:0048713)2.81585535
144innervation (GO:0060384)2.81418986
145regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.80830559
146regulation of neurotransmitter levels (GO:0001505)2.79594404
147presynaptic membrane assembly (GO:0097105)2.76341918
148mechanosensory behavior (GO:0007638)2.76320817
149regulation of excitatory postsynaptic membrane potential (GO:0060079)2.75788233
150positive regulation of membrane potential (GO:0045838)2.72803510
151oligodendrocyte differentiation (GO:0048709)2.71914630
152negative regulation of smoothened signaling pathway (GO:0045879)2.70524683

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.69214434
2* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.18028480
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07965269
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.92061514
5* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.79008710
6GBX2_23144817_ChIP-Seq_PC3_Human2.77045851
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.73914614
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.73914614
9* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.68719313
10AR_21572438_ChIP-Seq_LNCaP_Human2.64697642
11DROSHA_22980978_ChIP-Seq_HELA_Human2.63848864
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.63076056
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.56994356
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56843799
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.49081910
16* REST_21632747_ChIP-Seq_MESCs_Mouse2.47770814
17* EED_16625203_ChIP-ChIP_MESCs_Mouse2.46431516
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.43330550
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.36675006
20* RNF2_27304074_Chip-Seq_ESCs_Mouse2.36602967
21TRIM28_21343339_ChIP-Seq_HEK293_Human2.34947361
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.23706598
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.20445931
24* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.17451844
25* REST_18959480_ChIP-ChIP_MESCs_Mouse1.93413271
26* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.92699048
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.92566725
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.70827273
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68640678
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.66746043
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.60625566
32* RING1B_27294783_Chip-Seq_ESCs_Mouse1.55938257
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49453429
34CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.49065997
35* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49007965
36* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47884066
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.47192251
38RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.42203632
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41965121
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.37582720
41WT1_25993318_ChIP-Seq_PODOCYTE_Human1.33546554
42CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.32706619
43SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29297606
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28128972
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.27739384
46SMAD4_21799915_ChIP-Seq_A2780_Human1.27444217
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26806481
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26318735
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25209015
50* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.24469232
51* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23846107
52AR_19668381_ChIP-Seq_PC3_Human1.23373562
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21731817
54WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21334141
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21272340
56ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.21084212
57* CBX2_27304074_Chip-Seq_ESCs_Mouse1.20282722
58SOX2_21211035_ChIP-Seq_LN229_Gbm1.20185786
59* RING1B_27294783_Chip-Seq_NPCs_Mouse1.18989149
60* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18578937
61RXR_22108803_ChIP-Seq_LS180_Human1.17939391
62* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15587528
63ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15196501
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.14372609
65* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13009807
66KDM2B_26808549_Chip-Seq_K562_Human1.12286720
67NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11984485
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.11982611
69TP53_16413492_ChIP-PET_HCT116_Human1.11873382
70RUNX1_26923725_Chip-Seq_HPCs_Mouse1.10613848
71SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.10486753
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08601643
73* MITF_21258399_ChIP-Seq_MELANOMA_Human1.08554908
74MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08120012
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07802685
76AR_25329375_ChIP-Seq_VCAP_Human1.07148027
77SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.06843099
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06814064
79SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06363221
80* LXR_22292898_ChIP-Seq_THP-1_Human1.06354853
81* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05897618
82P300_19829295_ChIP-Seq_ESCs_Human1.04490044
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03184189
84STAT3_23295773_ChIP-Seq_U87_Human1.02592377
85ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01948110
86ESR2_21235772_ChIP-Seq_MCF-7_Human1.01914581
87SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01477788
88YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00240197
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97716205
90* TP53_20018659_ChIP-ChIP_R1E_Mouse0.97027670
91OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96768107
92SMAD3_21741376_ChIP-Seq_ESCs_Human0.96651140
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96523928
94ZNF274_21170338_ChIP-Seq_K562_Hela0.96022134
95PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.95485992
96SMC4_20622854_ChIP-Seq_HELA_Human0.95038572
97SMAD4_21741376_ChIP-Seq_HESCs_Human0.94129913
98TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93186061
99GATA1_26923725_Chip-Seq_HPCs_Mouse0.93059890
100NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.92582961
101* TP53_23651856_ChIP-Seq_MEFs_Mouse0.92541869
102EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92355127
103SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90790429
104ZFP281_27345836_Chip-Seq_ESCs_Mouse0.90656508
105SMAD3_21741376_ChIP-Seq_HESCs_Human0.90254856
106TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90082479
107* TET1_21490601_ChIP-Seq_MESCs_Mouse0.89186876
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88940142
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88940142
110ARNT_22903824_ChIP-Seq_MCF-7_Human0.88606004
111SOX3_22085726_ChIP-Seq_NPCs_Mouse0.88398339
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88367131
113RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87535998
114GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87420877
115P53_22127205_ChIP-Seq_FIBROBLAST_Human0.87307338
116* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86823755
117KDM2B_26808549_Chip-Seq_SUP-B15_Human0.86662090
118BCAT_22108803_ChIP-Seq_LS180_Human0.86074010
119RUNX2_22187159_ChIP-Seq_PCA_Human0.85355316
120SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.85182777
121AHR_22903824_ChIP-Seq_MCF-7_Human0.84406103
122* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84100109
123CTCF_27219007_Chip-Seq_Bcells_Human0.83998991
124DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.83782982
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83713192
126NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.83457949
127TBX20_22328084_ChIP-Seq_HEART_Mouse0.81445934
128TBX20_22080862_ChIP-Seq_HEART_Mouse0.81445934
129CLOCK_20551151_ChIP-Seq_293T_Human0.80528828
130SOX9_26525672_Chip-Seq_HEART_Mouse0.79343663
131POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.79021803
132* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.77853803
133ISL1_27105846_Chip-Seq_CPCs_Mouse0.76825756

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.49808870
2* MP0003635_abnormal_synaptic_transmissio3.51303292
3MP0003880_abnormal_central_pattern3.29225391
4MP0003690_abnormal_glial_cell3.18179529
5MP0004858_abnormal_nervous_system3.14498404
6MP0001486_abnormal_startle_reflex3.06739245
7MP0003329_amyloid_beta_deposits3.00848821
8MP0004270_analgesia2.98968557
9MP0009745_abnormal_behavioral_response2.95155495
10MP0009379_abnormal_foot_pigmentation2.91305388
11MP0002064_seizures2.87845351
12MP0002063_abnormal_learning/memory/cond2.79306118
13MP0009046_muscle_twitch2.77836145
14MP0005423_abnormal_somatic_nervous2.75699821
15MP0004885_abnormal_endolymph2.57544626
16MP0000372_irregular_coat_pigmentation2.57211084
17MP0005646_abnormal_pituitary_gland2.53478235
18MP0002572_abnormal_emotion/affect_behav2.49231390
19MP0002822_catalepsy2.40615740
20MP0009780_abnormal_chondrocyte_physiolo2.27995759
21MP0008569_lethality_at_weaning2.16019290
22MP0002272_abnormal_nervous_system2.15647496
23MP0001968_abnormal_touch/_nociception2.13394853
24MP0001440_abnormal_grooming_behavior2.04775096
25MP0001984_abnormal_olfaction2.03102416
26MP0004381_abnormal_hair_follicle2.01864010
27MP0002734_abnormal_mechanical_nocicepti2.01629699
28MP0002733_abnormal_thermal_nociception1.94018638
29MP0000778_abnormal_nervous_system1.89537865
30MP0001502_abnormal_circadian_rhythm1.88183266
31MP0002095_abnormal_skin_pigmentation1.84782234
32MP0003634_abnormal_glial_cell1.83109218
33MP0002254_reproductive_system_inflammat1.82255116
34MP0002736_abnormal_nociception_after1.81245469
35MP0002557_abnormal_social/conspecific_i1.78682387
36MP0001501_abnormal_sleep_pattern1.78623017
37MP0002067_abnormal_sensory_capabilities1.75158597
38MP0002909_abnormal_adrenal_gland1.71803430
39MP0003075_altered_response_to1.63261222
40MP0001970_abnormal_pain_threshold1.61671102
41MP0003633_abnormal_nervous_system1.61541188
42MP0000604_amyloidosis1.54348525
43MP0000955_abnormal_spinal_cord1.50721637
44MP0000920_abnormal_myelination1.49439584
45MP0004142_abnormal_muscle_tone1.46006504
46MP0003632_abnormal_nervous_system1.44809850
47MP0003631_nervous_system_phenotype1.44029234
48MP0002882_abnormal_neuron_morphology1.41178503
49MP0005408_hypopigmentation1.39923031
50MP0005386_behavior/neurological_phenoty1.39212142
51MP0004924_abnormal_behavior1.39212142
52MP0000371_diluted_coat_color1.34762273
53MP0001485_abnormal_pinna_reflex1.32285062
54MP0003136_yellow_coat_color1.32285058
55MP0005174_abnormal_tail_pigmentation1.32125099
56MP0000579_abnormal_nail_morphology1.31030938
57MP0005645_abnormal_hypothalamus_physiol1.30458965
58MP0002066_abnormal_motor_capabilities/c1.29802364
59MP0005167_abnormal_blood-brain_barrier1.28877567
60MP0002653_abnormal_ependyma_morphology1.21285526
61MP0002184_abnormal_innervation1.19703150
62MP0005075_abnormal_melanosome_morpholog1.19440112
63MP0004811_abnormal_neuron_physiology1.18675990
64MP0002735_abnormal_chemical_nociception1.17548205
65MP0005257_abnormal_intraocular_pressure1.15612002
66* MP0002152_abnormal_brain_morphology1.15577099
67MP0005551_abnormal_eye_electrophysiolog1.15154695
68MP0001529_abnormal_vocalization1.14688291
69MP0001905_abnormal_dopamine_level1.12296870
70MP0002638_abnormal_pupillary_reflex1.12106174
71MP0002090_abnormal_vision1.11621239
72MP0003183_abnormal_peptide_metabolism1.07988397
73MP0001177_atelectasis1.06322640
74MP0005058_abnormal_lysosome_morphology1.05278659
75MP0005171_absent_coat_pigmentation1.04557454
76MP0002089_abnormal_postnatal_growth/wei1.04144192
77MP0001299_abnormal_eye_distance/1.01757006
78MP0003137_abnormal_impulse_conducting1.01687501
79MP0002075_abnormal_coat/hair_pigmentati1.01094755
80MP0005623_abnormal_meninges_morphology1.00508872
81MP0009384_cardiac_valve_regurgitation0.98195379
82MP0001963_abnormal_hearing_physiology0.96078040
83MP0002229_neurodegeneration0.95055396
84MP0005379_endocrine/exocrine_gland_phen0.91388534
85MP0004742_abnormal_vestibular_system0.90981703
86MP0002938_white_spotting0.90173533
87MP0005253_abnormal_eye_physiology0.88400110
88MP0009840_abnormal_foam_cell0.88314877
89MP0003172_abnormal_lysosome_physiology0.88044935
90MP0003878_abnormal_ear_physiology0.87435221
91MP0005377_hearing/vestibular/ear_phenot0.87435221
92MP0000762_abnormal_tongue_morphology0.87004521
93MP0003283_abnormal_digestive_organ0.86296538
94MP0000569_abnormal_digit_pigmentation0.85971599
95MP0005595_abnormal_vascular_smooth0.82123587
96MP0002069_abnormal_eating/drinking_beha0.81446016
97MP0000631_abnormal_neuroendocrine_gland0.81052484
98MP0002752_abnormal_somatic_nervous0.80354083
99MP0000751_myopathy0.74412289
100MP0001186_pigmentation_phenotype0.74297319
101MP0003279_aneurysm0.74139345
102MP0006276_abnormal_autonomic_nervous0.73761180
103MP0001324_abnormal_eye_pigmentation0.72649911
104MP0002751_abnormal_autonomic_nervous0.72185208
105MP0001958_emphysema0.70069503
106MP0004215_abnormal_myocardial_fiber0.69800515
107MP0008874_decreased_physiological_sensi0.68539886
108MP0000566_synostosis0.68338767
109MP0000015_abnormal_ear_pigmentation0.67073878
110MP0000026_abnormal_inner_ear0.67008828
111MP0005391_vision/eye_phenotype0.64928645
112MP0004130_abnormal_muscle_cell0.62455007
113MP0005499_abnormal_olfactory_system0.61276113
114MP0005394_taste/olfaction_phenotype0.61276113
115MP0002249_abnormal_larynx_morphology0.60682620
116MP0003861_abnormal_nervous_system0.60130774
117MP0000647_abnormal_sebaceous_gland0.59663972
118MP0005166_decreased_susceptibility_to0.58554196
119MP0004043_abnormal_pH_regulation0.58106792
120MP0001943_abnormal_respiration0.57484819
121MP0008872_abnormal_physiological_respon0.57434330
122MP0008260_abnormal_autophagy0.56812690
123MP0000534_abnormal_ureter_morphology0.56776699
124MP0004085_abnormal_heartbeat0.56608492
125MP0003879_abnormal_hair_cell0.56607066
126MP0005248_abnormal_Harderian_gland0.55376132
127MP0000639_abnormal_adrenal_gland0.54042891

Predicted human phenotypes

RankGene SetZ-score
1Megalencephaly (HP:0001355)6.38877134
2White forelock (HP:0002211)5.82971101
3Myokymia (HP:0002411)5.35479077
4Patchy hypopigmentation of hair (HP:0011365)5.30590508
5Focal motor seizures (HP:0011153)5.21837014
6Aplasia involving bones of the upper limbs (HP:0009823)5.20251159
7Aplasia of the phalanges of the hand (HP:0009802)5.20251159
8Aplasia involving bones of the extremities (HP:0009825)5.20251159
9Neurofibrillary tangles (HP:0002185)5.09557347
10Morphological abnormality of the inner ear (HP:0011390)4.59421599
11Blue irides (HP:0000635)4.04947334
12Cerebral inclusion bodies (HP:0100314)4.00632930
13Focal seizures (HP:0007359)3.99206101
14Hemiparesis (HP:0001269)3.84834049
15Heterochromia iridis (HP:0001100)3.78117180
16Epileptic encephalopathy (HP:0200134)3.75800778
17Supranuclear gaze palsy (HP:0000605)3.75721248
18Action tremor (HP:0002345)3.64944299
19Abnormality of the diencephalon (HP:0010662)3.56798551
20Abnormality of binocular vision (HP:0011514)3.50265165
21Diplopia (HP:0000651)3.50265165
22Hemiplegia (HP:0002301)3.49750718
23Progressive cerebellar ataxia (HP:0002073)3.41805749
24Hypopigmentation of the fundus (HP:0007894)3.36056262
25Visual hallucinations (HP:0002367)3.13977766
26Anomalous pulmonary venous return (HP:0010772)3.06285630
27Dysdiadochokinesis (HP:0002075)3.05328405
28Clumsiness (HP:0002312)3.04318543
29Obstructive sleep apnea (HP:0002870)2.94359798
30Hypoplasia of the iris (HP:0007676)2.93623701
31Spastic paraparesis (HP:0002313)2.90858618
32Abnormality of the 4th metacarpal (HP:0010012)2.83695015
33Abnormal auditory evoked potentials (HP:0006958)2.82356246
34Ocular albinism (HP:0001107)2.81807371
35Postural instability (HP:0002172)2.78589361
36Abnormal eating behavior (HP:0100738)2.78217715
37Depression (HP:0000716)2.76458259
38Hyperacusis (HP:0010780)2.75577158
39Generalized tonic-clonic seizures (HP:0002069)2.72985221
40Split foot (HP:0001839)2.70774060
41Synostosis involving the elbow (HP:0003938)2.69002948
42Humeroradial synostosis (HP:0003041)2.69002948
43Intention tremor (HP:0002080)2.68474891
44Ankle clonus (HP:0011448)2.65233843
45Overriding aorta (HP:0002623)2.63586125
46Elfin facies (HP:0004428)2.63562451
47Abnormality of the pulmonary veins (HP:0011718)2.60844056
48Truncal ataxia (HP:0002078)2.59074568
49Atonic seizures (HP:0010819)2.58239755
50Abnormality of the ischium (HP:0003174)2.58211035
51Status epilepticus (HP:0002133)2.57414112
52Dysmetria (HP:0001310)2.56222883
53Abnormality of cochlea (HP:0000375)2.50593586
54Synostosis of carpal bones (HP:0005048)2.50533640
55Oligodactyly (HP:0012165)2.49570434
56Akinesia (HP:0002304)2.46707645
57Iris hypopigmentation (HP:0007730)2.45854938
58Cerebral hypomyelination (HP:0006808)2.45766400
59Febrile seizures (HP:0002373)2.42539461
60Absent epiphyses (HP:0010577)2.41972714
61Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.41972714
62Pseudobulbar signs (HP:0002200)2.40006135
63Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.38557882
64Mesangial abnormality (HP:0001966)2.37793805
65Impaired vibration sensation in the lower limbs (HP:0002166)2.34285497
66Abnormality of secondary sexual hair (HP:0009888)2.31874588
67Abnormality of the axillary hair (HP:0100134)2.31874588
68Dialeptic seizures (HP:0011146)2.31403473
69Bowel incontinence (HP:0002607)2.29789125
70Back pain (HP:0003418)2.27020612
71Lower limb muscle weakness (HP:0007340)2.23926514
72Hypoplastic left heart (HP:0004383)2.23856324
73Anxiety (HP:0000739)2.23268493
74Vertebral clefting (HP:0008428)2.22708749
75Bell-shaped thorax (HP:0001591)2.22545551
76Oligodactyly (hands) (HP:0001180)2.20826734
77Decreased lacrimation (HP:0000633)2.20391949
78Urinary bladder sphincter dysfunction (HP:0002839)2.19008473
79Absence seizures (HP:0002121)2.17631273
80Truncus arteriosus (HP:0001660)2.17578455
81Congenital sensorineural hearing impairment (HP:0008527)2.14816234
82Insomnia (HP:0100785)2.14373205
83Hyperventilation (HP:0002883)2.12717804
84Adactyly (HP:0009776)2.12717693
85Hypoplastic ischia (HP:0003175)2.12545285
86Renovascular hypertension (HP:0100817)2.10873093
87Abnormality of the middle phalanges of the toes (HP:0010183)2.10142191
88Mixed hearing impairment (HP:0000410)2.08145374
89Stereotypic behavior (HP:0000733)2.07778457
90Abnormal large intestine physiology (HP:0012700)2.06601052
91Spastic gait (HP:0002064)2.05746530
92Fibular hypoplasia (HP:0003038)2.05336576
93Bradykinesia (HP:0002067)2.04735246
94Gaze-evoked nystagmus (HP:0000640)2.04137524
95Bronchomalacia (HP:0002780)2.04118312
96Rigidity (HP:0002063)2.02151412
97Polyphagia (HP:0002591)2.02141637
98Peripheral hypomyelination (HP:0007182)2.02066289
99Generalized hypopigmentation (HP:0007513)2.01351688
100Premature graying of hair (HP:0002216)1.99726998
101Rib fusion (HP:0000902)1.98027111
102Increased CSF protein (HP:0002922)1.96801804
103Ulnar claw (HP:0001178)1.96660681
104Abnormal social behavior (HP:0012433)1.96256826
105Impaired social interactions (HP:0000735)1.96256826
106Poor eye contact (HP:0000817)1.96188316
107Glossoptosis (HP:0000162)1.95427541
108Postural tremor (HP:0002174)1.95039217
109Aplasia/Hypoplasia of the macula (HP:0008059)1.94506639
110Metabolic alkalosis (HP:0200114)1.93540550
111Broad-based gait (HP:0002136)1.93123315
112Dementia (HP:0000726)1.91321121
113Shallow orbits (HP:0000586)1.90327158
114Increased circulating renin level (HP:0000848)1.87690600
115Anophthalmia (HP:0000528)1.87499826
116Neuronal loss in central nervous system (HP:0002529)1.86492720
117Hypoplastic nipples (HP:0002557)1.86255628
118Torticollis (HP:0000473)1.85863091
119Renal duplication (HP:0000075)1.84505482
120Hypsarrhythmia (HP:0002521)1.84504937
121Foot dorsiflexor weakness (HP:0009027)1.84446612
122Enlarged epiphyses (HP:0010580)1.84307686
123EEG with generalized epileptiform discharges (HP:0011198)1.83384428
124Aplasia/Hypoplasia affecting the retina (HP:0008061)1.82506961
125Missing ribs (HP:0000921)1.82432164
126Coronal craniosynostosis (HP:0004440)1.81953856
127Long nose (HP:0003189)1.80433129
128Laryngomalacia (HP:0001601)1.80311380
129Epileptiform EEG discharges (HP:0011182)1.79986536
130Tetraplegia (HP:0002445)1.79658144
131Supernumerary ribs (HP:0005815)1.79537729
132Urethral obstruction (HP:0000796)1.79311330
133Scanning speech (HP:0002168)1.78837449
134Flat cornea (HP:0007720)1.77784088
135Neoplasm of the oral cavity (HP:0100649)1.77506716
136Paraparesis (HP:0002385)1.77376862
137Urinary urgency (HP:0000012)1.76816687
138Turricephaly (HP:0000262)1.76259103
139Impaired vibratory sensation (HP:0002495)1.75281382
140Carpal synostosis (HP:0009702)1.75121459
141Insidious onset (HP:0003587)1.74209227
142Termporal pattern (HP:0011008)1.74209227
143Relative macrocephaly (HP:0004482)1.73974125
144Supernumerary nipples (HP:0002558)1.73646822
145Esophageal atresia (HP:0002032)1.73521832
146Abnormality of the foot musculature (HP:0001436)1.72572630
147Hypokalemic alkalosis (HP:0001949)1.71892384
148Severe global developmental delay (HP:0011344)1.70965894
149Aqueductal stenosis (HP:0002410)1.70207015
150Abnormality of the dental pulp (HP:0006479)1.68578641
151Generalized myoclonic seizures (HP:0002123)1.68287477
152Genetic anticipation (HP:0003743)1.68235848
153Alacrima (HP:0000522)1.67466437
154Annular pancreas (HP:0001734)1.66351454
155Congenital malformation of the right heart (HP:0011723)1.65123971
156Clonus (HP:0002169)1.65103624
157Mutism (HP:0002300)1.64789438
158Abnormality of the corticospinal tract (HP:0002492)1.64730455
159Abnormality of ocular smooth pursuit (HP:0000617)1.64610963
160Ankyloglossia (HP:0010296)1.64401516
161Gait ataxia (HP:0002066)1.64126571
162Narrow nasal bridge (HP:0000446)1.64097824
163Focal dystonia (HP:0004373)1.63270727
164Limb ataxia (HP:0002070)1.61464972
165Excessive salivation (HP:0003781)1.61212948
166Drooling (HP:0002307)1.61212948
167Polygenic inheritance (HP:0010982)1.60448726
168Confusion (HP:0001289)1.58920994
169Athetosis (HP:0002305)1.58611045

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.60337750
2TNIK3.88122459
3LMTK23.59343587
4NTRK33.29706606
5NTRK23.13641482
6PRKD33.05206460
7PHKG12.89366006
8PHKG22.89366006
9MAP3K92.40750229
10TYRO32.36949137
11ERBB42.18045027
12MINK12.08743549
13MARK12.05037440
14PAK61.92604988
15MAP3K41.84543122
16NTRK11.78063822
17MAPK131.63955709
18DAPK21.62485280
19KSR21.58247215
20CASK1.55240834
21CAMKK11.54450578
22ERBB21.51985176
23PRPF4B1.46535306
24MAPK151.40108391
25CDK51.37929851
26MUSK1.33263804
27MAP2K71.32180355
28FES1.31655981
29MAP3K131.27503088
30SGK2231.24757479
31SGK4941.24757479
32TRIB31.20484272
33PNCK1.16753456
34STK381.15240009
35SIK11.13402164
36CAMK2D1.10587634
37PRKCG1.10219801
38SGK21.09578933
39KSR11.08121557
40SGK31.01328175
41PRKCH1.00751683
42PINK10.98753384
43UHMK10.96522263
44FGR0.95355548
45MAP2K40.91995485
46FGFR40.88686009
47RIPK40.87919199
48PBK0.87800285
49CSNK1G30.85355556
50CDK150.82810922
51FGFR20.81715794
52GRK50.81133920
53CDK180.79330194
54BMX0.78931739
55CSNK1A1L0.78496203
56CDK30.77676917
57PAK30.77417103
58MAPKAPK50.75685575
59NEK60.75204293
60ICK0.74432481
61PDGFRA0.73006694
62CAMK2A0.72960787
63CDK140.72799707
64MAP3K20.72297496
65CDK11A0.72111371
66CAMKK20.71407008
67ROCK10.71400254
68CDC42BPA0.70923917
69DYRK1A0.70767400
70RET0.69289384
71CSNK1G10.69244820
72RIPK10.68241534
73DDR20.67260914
74DYRK20.66320006
75OXSR10.66185353
76ALK0.64947828
77MAPK120.64832540
78ROCK20.64574387
79SIK20.64272067
80PRKD10.63507489
81MAPK110.62606127
82TNK20.62583472
83IRAK20.60127735
84PTK20.59134787
85SGK10.58199414
86CAMK10.57441077
87CAMK1G0.56763775
88PLK20.55942868
89RPS6KA30.54092473
90TAOK10.53639340
91DMPK0.53163607
92LRRK20.51662561
93PRKCE0.50457797
94STK110.50265382
95DAPK10.49847054
96MET0.49708537
97EPHB10.49404963
98MARK20.49345941
99ARAF0.48663212
100RAF10.48150273
101STK390.47498471
102FYN0.47316822
103JAK20.47137426
104FGFR30.47065289
105CSNK1G20.46344179
106ADRBK10.46142300
107WNK10.45866421
108TSSK60.44415523
109CDK190.44392887
110PDPK10.44121750
111PRKCZ0.43455687
112PRKD20.42381899
113MAP3K70.42276203
114MAPK100.41721887
115PDK10.40616210
116CSNK1D0.40006105
117PDGFRB0.39103163
118CAMK2B0.38932345
119CAMK2G0.38368262
120PKN10.37876002
121PTK2B0.37581523
122MAPK70.37144102
123SRC0.36380986
124PRKDC0.36278973
125STK38L0.35841554
126EPHA30.32174394
127PIK3CA0.31294723
128WEE10.30733778
129TIE10.29482320
130PRKG10.27521741
131BRSK10.27437763
132PAK20.25624118
133CSNK1A10.24735875

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.18929857
2Fatty acid biosynthesis_Homo sapiens_hsa000613.11869550
3Nicotine addiction_Homo sapiens_hsa050332.93232961
4Glutamatergic synapse_Homo sapiens_hsa047242.54847457
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.48848051
6GABAergic synapse_Homo sapiens_hsa047272.48040741
7Notch signaling pathway_Homo sapiens_hsa043302.31552891
8Olfactory transduction_Homo sapiens_hsa047402.20652426
9Circadian entrainment_Homo sapiens_hsa047132.19475398
10Synaptic vesicle cycle_Homo sapiens_hsa047212.09201808
11Salivary secretion_Homo sapiens_hsa049702.06372408
12Morphine addiction_Homo sapiens_hsa050322.00037705
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.97199742
14Long-term potentiation_Homo sapiens_hsa047201.93566689
15Gastric acid secretion_Homo sapiens_hsa049711.86060841
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.83262652
17Insulin secretion_Homo sapiens_hsa049111.81167736
18Amphetamine addiction_Homo sapiens_hsa050311.71650594
19Cocaine addiction_Homo sapiens_hsa050301.59654201
20Cholinergic synapse_Homo sapiens_hsa047251.51488438
21Dopaminergic synapse_Homo sapiens_hsa047281.47432339
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.42911751
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.42761433
24Fatty acid metabolism_Homo sapiens_hsa012121.40875023
25Calcium signaling pathway_Homo sapiens_hsa040201.37313888
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.36991649
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36949623
28Long-term depression_Homo sapiens_hsa047301.29564183
29Renin secretion_Homo sapiens_hsa049241.29346281
30Taste transduction_Homo sapiens_hsa047421.21253044
31cAMP signaling pathway_Homo sapiens_hsa040241.20940820
32Oxytocin signaling pathway_Homo sapiens_hsa049211.18077451
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15611531
34Serotonergic synapse_Homo sapiens_hsa047261.15254399
35Gap junction_Homo sapiens_hsa045401.14460882
36Phospholipase D signaling pathway_Homo sapiens_hsa040721.11504338
37GnRH signaling pathway_Homo sapiens_hsa049121.11340527
38Dorso-ventral axis formation_Homo sapiens_hsa043201.10543216
39Axon guidance_Homo sapiens_hsa043601.09071813
40Steroid biosynthesis_Homo sapiens_hsa001001.07859548
41beta-Alanine metabolism_Homo sapiens_hsa004101.04706912
42Bile secretion_Homo sapiens_hsa049761.02116697
43Histidine metabolism_Homo sapiens_hsa003401.01983877
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00203464
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00191069
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.97601618
47Melanogenesis_Homo sapiens_hsa049160.97260062
48Glioma_Homo sapiens_hsa052140.95903526
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93801381
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93191900
51Vibrio cholerae infection_Homo sapiens_hsa051100.89540939
52Pancreatic secretion_Homo sapiens_hsa049720.88518603
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87991717
54Non-small cell lung cancer_Homo sapiens_hsa052230.85712891
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84942011
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82910815
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82321653
58Estrogen signaling pathway_Homo sapiens_hsa049150.81906673
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79623118
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78214173
61Fatty acid degradation_Homo sapiens_hsa000710.77081100
62ErbB signaling pathway_Homo sapiens_hsa040120.76565438
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75026671
64Thyroid hormone synthesis_Homo sapiens_hsa049180.74013268
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73398570
66Circadian rhythm_Homo sapiens_hsa047100.72944717
67Choline metabolism in cancer_Homo sapiens_hsa052310.71537242
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71127362
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.70996799
70Arginine and proline metabolism_Homo sapiens_hsa003300.69322141
71Type II diabetes mellitus_Homo sapiens_hsa049300.69271056
72Melanoma_Homo sapiens_hsa052180.67854679
73Hippo signaling pathway_Homo sapiens_hsa043900.67698656
74Colorectal cancer_Homo sapiens_hsa052100.65878006
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64449312
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63984108
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.63982715
78PPAR signaling pathway_Homo sapiens_hsa033200.63125397
79MicroRNAs in cancer_Homo sapiens_hsa052060.62294488
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62197774
81Chronic myeloid leukemia_Homo sapiens_hsa052200.62123274
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60708743
83Cardiac muscle contraction_Homo sapiens_hsa042600.60456394
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.58954918
85Adherens junction_Homo sapiens_hsa045200.57868282
86Butanoate metabolism_Homo sapiens_hsa006500.57763970
87Dilated cardiomyopathy_Homo sapiens_hsa054140.57495837
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56835352
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.56616862
90Rap1 signaling pathway_Homo sapiens_hsa040150.55971960
91Sulfur relay system_Homo sapiens_hsa041220.55337042
92Mineral absorption_Homo sapiens_hsa049780.54763678
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53869795
94Tyrosine metabolism_Homo sapiens_hsa003500.52181032
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49453107
96AMPK signaling pathway_Homo sapiens_hsa041520.49309514
97Pancreatic cancer_Homo sapiens_hsa052120.48325117
98Ether lipid metabolism_Homo sapiens_hsa005650.48116761
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.47955853
100Prion diseases_Homo sapiens_hsa050200.47751874
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.47683801
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46895381
103Collecting duct acid secretion_Homo sapiens_hsa049660.46499012
104MAPK signaling pathway_Homo sapiens_hsa040100.46373288
105Ras signaling pathway_Homo sapiens_hsa040140.45626500
106Inositol phosphate metabolism_Homo sapiens_hsa005620.45282667
107Glucagon signaling pathway_Homo sapiens_hsa049220.44518185
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.44295566
109Lysine degradation_Homo sapiens_hsa003100.43533594
110Hedgehog signaling pathway_Homo sapiens_hsa043400.41755260
111Basal cell carcinoma_Homo sapiens_hsa052170.41372202
112mTOR signaling pathway_Homo sapiens_hsa041500.40813561
113Other glycan degradation_Homo sapiens_hsa005110.39603936
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39416453
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38853497
116Ovarian steroidogenesis_Homo sapiens_hsa049130.38230230
117Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38211714
118Vitamin B6 metabolism_Homo sapiens_hsa007500.37138805
119Wnt signaling pathway_Homo sapiens_hsa043100.35265043
120Endocytosis_Homo sapiens_hsa041440.34907720
121Renal cell carcinoma_Homo sapiens_hsa052110.34750964
122VEGF signaling pathway_Homo sapiens_hsa043700.32422117
123African trypanosomiasis_Homo sapiens_hsa051430.31717420
124Arginine biosynthesis_Homo sapiens_hsa002200.30901575
125Oocyte meiosis_Homo sapiens_hsa041140.30724674
126Endometrial cancer_Homo sapiens_hsa052130.30310642

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