BCAP31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the B-cell receptor associated protein 31 superfamily. The encoded protein is a multi-pass transmembrane protein of the endoplasmic reticulum that is involved in the anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi and in caspase 8-mediated apoptosis. Microdeletions in this gene are associated with contiguous ABCD1/DXS1375E deletion syndrome (CADDS), a neonatal disorder. Alternative splicing of this gene results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 16. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein maturation by protein folding (GO:0022417)5.22677326
2Golgi transport vesicle coating (GO:0048200)4.70304857
3COPI coating of Golgi vesicle (GO:0048205)4.70304857
4proteasome assembly (GO:0043248)4.32257230
5glycosphingolipid catabolic process (GO:0046479)4.26105223
6ribosomal small subunit assembly (GO:0000028)4.23106444
7fatty acid elongation (GO:0030497)4.19229201
8glycolipid catabolic process (GO:0019377)3.83977132
9pentose-phosphate shunt (GO:0006098)3.80406482
10barbed-end actin filament capping (GO:0051016)3.56752039
11signal peptide processing (GO:0006465)3.56698332
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.56283536
13regulation of superoxide anion generation (GO:0032928)3.46285150
14amino sugar catabolic process (GO:0046348)3.45895945
15ribosomal small subunit biogenesis (GO:0042274)3.42428207
16antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.42373973
17L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.37594611
18ceramide catabolic process (GO:0046514)3.37468732
19regulation of cellular amino acid metabolic process (GO:0006521)3.34924148
20pinocytosis (GO:0006907)3.31948759
21cotranslational protein targeting to membrane (GO:0006613)3.30686895
22glucose catabolic process (GO:0006007)3.27402945
23SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.26454864
24regulation of metalloenzyme activity (GO:0048552)3.24289239
25protein targeting to ER (GO:0045047)3.24233113
26protein localization to endosome (GO:0036010)3.22091224
27viral transcription (GO:0019083)3.20166336
28oligosaccharide catabolic process (GO:0009313)3.18999459
29negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.18580989
30amino acid salvage (GO:0043102)3.15962814
31L-methionine salvage (GO:0071267)3.15962814
32L-methionine biosynthetic process (GO:0071265)3.15962814
33* protein localization to endoplasmic reticulum (GO:0070972)3.14929819
34translational termination (GO:0006415)3.13935925
35aldehyde catabolic process (GO:0046185)3.12533600
36mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.10390930
37negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.09786949
38DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.06334087
39establishment of protein localization to endoplasmic reticulum (GO:0072599)3.05602827
40signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.99926657
41intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.99926657
42maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.99870642
43protein retention in ER lumen (GO:0006621)2.99073686
44DNA deamination (GO:0045006)2.99034699
45response to thyroid hormone (GO:0097066)2.99000748
46nucleobase-containing small molecule interconversion (GO:0015949)2.98265107
47negative regulation of ligase activity (GO:0051352)2.97520818
48negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.97520818
49pentose metabolic process (GO:0019321)2.97111259
50signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.96945961
51signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.96945961
52signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.96945961
53maturation of SSU-rRNA (GO:0030490)2.95301187
54sphingolipid catabolic process (GO:0030149)2.95030297
55membrane lipid catabolic process (GO:0046466)2.94796958
56cholesterol biosynthetic process (GO:0006695)2.92388876
57long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.92342434
58positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.92296503
59NADH metabolic process (GO:0006734)2.87348407
60* antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.86704943
61energy coupled proton transport, down electrochemical gradient (GO:0015985)2.83022446
62ATP synthesis coupled proton transport (GO:0015986)2.83022446
63signal transduction involved in DNA damage checkpoint (GO:0072422)2.82770414
64signal transduction involved in DNA integrity checkpoint (GO:0072401)2.82770414
65ribosomal large subunit biogenesis (GO:0042273)2.82353307
66regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.81719331
67fatty-acyl-CoA metabolic process (GO:0035337)2.77360373
68signal transduction involved in cell cycle checkpoint (GO:0072395)2.75589237
69long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.75202489
70glucose 6-phosphate metabolic process (GO:0051156)2.75006495
71protein neddylation (GO:0045116)2.73154167
72translational elongation (GO:0006414)2.72488698
73positive regulation of monocyte chemotaxis (GO:0090026)2.72181791
74regulation of cholesterol storage (GO:0010885)2.71890951
75fatty-acyl-CoA biosynthetic process (GO:0046949)2.71451947
76termination of RNA polymerase III transcription (GO:0006386)2.71237113
77transcription elongation from RNA polymerase III promoter (GO:0006385)2.71237113
78low-density lipoprotein particle clearance (GO:0034383)2.70704166
79platelet dense granule organization (GO:0060155)2.70308234
80response to interferon-beta (GO:0035456)2.69027004
81* negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.68755488
82translation (GO:0006412)2.68473128
83cellular response to thyroid hormone stimulus (GO:0097067)2.68260318
84cellular copper ion homeostasis (GO:0006878)2.68209132
85mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.67134040
86mitochondrial respiratory chain complex I assembly (GO:0032981)2.67134040
87NADH dehydrogenase complex assembly (GO:0010257)2.67134040
88negative regulation of nitric oxide biosynthetic process (GO:0045019)2.65653723
89deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.65260882
90anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.64879817
91amyloid precursor protein metabolic process (GO:0042982)2.64272361
92mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.64124139
93amyloid precursor protein catabolic process (GO:0042987)2.62298690
94regulation of mononuclear cell migration (GO:0071675)2.62289741
95regulation of superoxide metabolic process (GO:0090322)2.61883830
96hyaluronan catabolic process (GO:0030214)2.61268055
97positive regulation of Cdc42 GTPase activity (GO:0043089)2.60690583
98sterol biosynthetic process (GO:0016126)2.60627486
99acyl-CoA biosynthetic process (GO:0071616)2.59443443
100thioester biosynthetic process (GO:0035384)2.59443443
101purine nucleobase biosynthetic process (GO:0009113)2.59170577
102respiratory electron transport chain (GO:0022904)2.58746763
103formation of translation preinitiation complex (GO:0001731)2.58661593
104erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.57415969
105L-phenylalanine catabolic process (GO:0006559)2.57415969
106cyclooxygenase pathway (GO:0019371)2.56894113
107retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.55992592
108pyrimidine nucleoside salvage (GO:0043097)2.54924474
109pyrimidine-containing compound salvage (GO:0008655)2.54924474
110viral life cycle (GO:0019058)2.54920918
111positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.54779324
112electron transport chain (GO:0022900)2.52124986
113pantothenate metabolic process (GO:0015939)2.51916394
114regulation of cellular amine metabolic process (GO:0033238)2.51876669
115eosinophil chemotaxis (GO:0048245)2.51478324
116respiratory chain complex IV assembly (GO:0008535)2.51417609
117proline biosynthetic process (GO:0006561)2.50168537
118apoptotic cell clearance (GO:0043277)2.49754227
119oxidative phosphorylation (GO:0006119)2.49589423
120neutrophil activation involved in immune response (GO:0002283)2.49448476
121L-serine metabolic process (GO:0006563)2.49179097
122GDP-mannose metabolic process (GO:0019673)2.48738275
123translational initiation (GO:0006413)2.48253976
124cofactor catabolic process (GO:0051187)2.48116805
125* endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.47983058
126GPI anchor biosynthetic process (GO:0006506)2.47851648
127erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.47447945
128L-phenylalanine metabolic process (GO:0006558)2.47447945
129transferrin transport (GO:0033572)2.46404558
130cellular response to arsenic-containing substance (GO:0071243)2.46393484
131positive regulation of ligase activity (GO:0051351)2.45978258
132negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.45952096
133keratan sulfate catabolic process (GO:0042340)2.45420259
134energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.44680589
135ATP hydrolysis coupled proton transport (GO:0015991)2.44680589
136regulation of integrin-mediated signaling pathway (GO:2001044)2.44387309
137nuclear envelope reassembly (GO:0031468)2.44097524
138mitotic nuclear envelope reassembly (GO:0007084)2.44097524
139chaperone-mediated protein transport (GO:0072321)2.42514517
140positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.41421999
141decidualization (GO:0046697)2.41411477
142phagosome maturation (GO:0090382)2.38727454
143protein complex biogenesis (GO:0070271)2.37903660
144rRNA modification (GO:0000154)2.35884942
145regulation of podosome assembly (GO:0071801)2.35795058
146lipopolysaccharide biosynthetic process (GO:0009103)2.35514171
147response to peptidoglycan (GO:0032494)2.35384908
148regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.35124430
149antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.34900273
150negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.34234933
151branched-chain amino acid catabolic process (GO:0009083)2.34040225
152N-acetylneuraminate metabolic process (GO:0006054)2.33761158
153negative regulation of mitochondrion organization (GO:0010823)2.33394753
154very long-chain fatty acid metabolic process (GO:0000038)2.33261860
155glycoside metabolic process (GO:0016137)2.33136764
156acyl-CoA metabolic process (GO:0006637)2.32705969
157thioester metabolic process (GO:0035383)2.32705969
158NADPH regeneration (GO:0006740)2.32167821
159nucleotide salvage (GO:0043173)2.32003788
160valine metabolic process (GO:0006573)2.31820986
161cellular protein complex disassembly (GO:0043624)2.30567121
162nucleobase biosynthetic process (GO:0046112)2.30550647
163tricarboxylic acid cycle (GO:0006099)2.28454557
1647-methylguanosine mRNA capping (GO:0006370)2.28078725
165sphingosine metabolic process (GO:0006670)2.27604502
166cullin deneddylation (GO:0010388)2.27258174
167serine family amino acid biosynthetic process (GO:0009070)2.27113302
168NIK/NF-kappaB signaling (GO:0038061)2.25289387
169purine nucleotide salvage (GO:0032261)2.24716436
170trivalent inorganic cation transport (GO:0072512)2.22863242
171ferric iron transport (GO:0015682)2.22863242
172lipopolysaccharide-mediated signaling pathway (GO:0031663)2.22278566

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.76925789
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.55409121
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.46550414
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.37952615
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.36210518
6* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.15019654
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.14404746
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.10953751
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.93167733
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.88480198
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.84500343
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.71807333
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.71183610
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.69913891
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.49085919
16CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.44735187
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.38312435
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.27659227
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.27179320
20EGR1_23403033_ChIP-Seq_LIVER_Mouse2.22474347
21CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.19804590
22RARG_19884340_ChIP-ChIP_MEFs_Mouse2.14144932
23VDR_23849224_ChIP-Seq_CD4+_Human2.14044931
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.13256780
25* IRF8_22096565_ChIP-ChIP_GC-B_Human2.12848716
26ZNF263_19887448_ChIP-Seq_K562_Human2.06666294
27* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.06120379
28IRF8_21731497_ChIP-ChIP_J774_Mouse2.05067068
29* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.04587164
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.02721540
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.91948826
32DCP1A_22483619_ChIP-Seq_HELA_Human1.90822333
33E2F7_22180533_ChIP-Seq_HELA_Human1.85266722
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.83069737
35* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.81344856
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.80590504
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.79987765
38ELK1_19687146_ChIP-ChIP_HELA_Human1.79858504
39RXR_22158963_ChIP-Seq_LIVER_Mouse1.79807819
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.79284239
41STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.76703943
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.76443516
43TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73260704
44LXR_22292898_ChIP-Seq_THP-1_Human1.70633257
45FOXP3_21729870_ChIP-Seq_TREG_Human1.69522610
46ERG_20887958_ChIP-Seq_HPC-7_Mouse1.69077839
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.66548489
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63703612
49PPARA_22158963_ChIP-Seq_LIVER_Mouse1.62866772
50RACK7_27058665_Chip-Seq_MCF-7_Human1.62708138
51DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.61831639
52XRN2_22483619_ChIP-Seq_HELA_Human1.60797979
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.60737844
54* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.58436204
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.53426728
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.53192433
57VDR_21846776_ChIP-Seq_THP-1_Human1.52408421
58HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.49026450
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.48892910
60ELK1_22589737_ChIP-Seq_MCF10A_Human1.45299266
61MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.44577705
62* GABP_19822575_ChIP-Seq_HepG2_Human1.43175033
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42302056
64SPI1_23547873_ChIP-Seq_NB4_Human1.42067914
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41032430
66TP63_17297297_ChIP-ChIP_HaCaT_Human1.39969550
67CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.39641044
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39575665
69SRY_22984422_ChIP-ChIP_TESTIS_Rat1.39153925
70KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.32049758
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31404973
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.30140488
73MYB_21317192_ChIP-Seq_ERMYB_Mouse1.29877493
74MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.27927611
75GATA1_22025678_ChIP-Seq_K562_Human1.27556974
76TET1_21451524_ChIP-Seq_MESCs_Mouse1.27362822
77PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.26920019
78* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24460368
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22964493
80AR_21909140_ChIP-Seq_LNCAP_Human1.22761479
81SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.21677530
82ATF3_27146783_Chip-Seq_COLON_Human1.20777349
83RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.19148852
84CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.18310725
85NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17377535
86YY1_21170310_ChIP-Seq_MESCs_Mouse1.15355261
87THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14056749
88TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13895191
89STAT4_19710469_ChIP-ChIP_TH1__Mouse1.13807688
90CTCF_18555785_ChIP-Seq_MESCs_Mouse1.13713693
91KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13289184
92ELF1_20517297_ChIP-Seq_JURKAT_Human1.13045738
93TTF2_22483619_ChIP-Seq_HELA_Human1.12664237
94BRD4_27068464_Chip-Seq_AML-cells_Mouse1.11394901
95TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09728683
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09703456
97HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09248523
98FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.08577933
99POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06761666
100SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05624599
101KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04787435
102CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04670228
103BCOR_27268052_Chip-Seq_Bcells_Human1.04553195
104P68_20966046_ChIP-Seq_HELA_Human1.04524142
105ESR1_21235772_ChIP-Seq_MCF-7_Human1.04324788
106NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03519555
107SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03322604
108VDR_24763502_ChIP-Seq_THP-1_Human1.03173591
109LXR_22158963_ChIP-Seq_LIVER_Mouse1.02971671
110RUNX1_22412390_ChIP-Seq_EML_Mouse1.02543105
111ZFX_18555785_ChIP-Seq_MESCs_Mouse1.01891306
112TBX5_21415370_ChIP-Seq_HL-1_Mouse1.01258157
113POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00088419
114* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99188713
115IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.99078394
116BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97526027
117PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.96569262
118STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94139351
119NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94099018
120E2F4_17652178_ChIP-ChIP_JURKAT_Human0.93976979
121MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.93214646
122BP1_19119308_ChIP-ChIP_Hs578T_Human0.92858564
123ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92653728
124ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.92054798
125SOX17_20123909_ChIP-Seq_XEN_Mouse0.90736372
126CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90663936
127CLOCK_20551151_ChIP-Seq_293T_Human0.89826635
128TFEB_21752829_ChIP-Seq_HELA_Human0.89369091
129LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87431727
130NANOG_18555785_ChIP-Seq_MESCs_Mouse0.87109861
131CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86982124
132ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.86762333
133FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.86375706
134MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.86217874
135SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.85343252
136GATA1_22383799_ChIP-Seq_G1ME_Mouse0.85303144
137SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.85043551
138GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82219898
139RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.81146254
140GATA2_22383799_ChIP-Seq_G1ME_Mouse0.80967100

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.06584824
2MP0003186_abnormal_redox_activity3.25746798
3MP0003724_increased_susceptibility_to2.76737899
4MP0002877_abnormal_melanocyte_morpholog2.50915660
5MP0009840_abnormal_foam_cell2.50052569
6MP0002139_abnormal_hepatobiliary_system2.49753328
7MP0003172_abnormal_lysosome_physiology2.44057968
8MP0005360_urolithiasis2.31313480
9MP0005058_abnormal_lysosome_morphology2.29594508
10MP0008438_abnormal_cutaneous_collagen2.29159109
11MP0008875_abnormal_xenobiotic_pharmacok2.19072204
12MP0003075_altered_response_to2.16315383
13MP0003303_peritoneal_inflammation2.11445316
14MP0009785_altered_susceptibility_to2.08705947
15MP0001835_abnormal_antigen_presentation2.07751708
16MP0003191_abnormal_cellular_cholesterol2.04237032
17MP0010234_abnormal_vibrissa_follicle2.03480327
18MP0006082_CNS_inflammation2.02322378
19MP0004147_increased_porphyrin_level1.97516607
20MP0003195_calcinosis1.96238622
21MP0003453_abnormal_keratinocyte_physiol1.89714541
22MP0000604_amyloidosis1.88135939
23MP0003656_abnormal_erythrocyte_physiolo1.84803976
24MP0003950_abnormal_plasma_membrane1.81948387
25MP0001764_abnormal_homeostasis1.81712079
26MP0005365_abnormal_bile_salt1.76605706
27MP0005085_abnormal_gallbladder_physiolo1.76566007
28MP0006054_spinal_hemorrhage1.72042762
29MP0003566_abnormal_cell_adhesion1.72002374
30MP0001542_abnormal_bone_strength1.71343692
31MP0005165_increased_susceptibility_to1.70363727
32MP0002132_abnormal_respiratory_system1.66082162
33MP0009379_abnormal_foot_pigmentation1.64401910
34MP0006036_abnormal_mitochondrial_physio1.62966491
35MP0002148_abnormal_hypersensitivity_rea1.61906829
36MP0005025_abnormal_response_to1.60616311
37MP0009333_abnormal_splenocyte_physiolog1.53389454
38MP0002419_abnormal_innate_immunity1.52014363
39MP0005332_abnormal_amino_acid1.49097253
40MP0005671_abnormal_response_to1.49077123
41MP0003436_decreased_susceptibility_to1.48927233
42MP0005408_hypopigmentation1.46819221
43MP0003693_abnormal_embryo_hatching1.46179626
44MP0003718_maternal_effect1.45034249
45MP0003329_amyloid_beta_deposits1.43943902
46MP0001853_heart_inflammation1.41781530
47MP0005257_abnormal_intraocular_pressure1.41312202
48MP0003011_delayed_dark_adaptation1.38920297
49MP0005275_abnormal_skin_tensile1.36639091
50MP0003705_abnormal_hypodermis_morpholog1.36090059
51MP0010329_abnormal_lipoprotein_level1.33874002
52MP0001849_ear_inflammation1.32051056
53MP0005000_abnormal_immune_tolerance1.31770072
54MP0008469_abnormal_protein_level1.31302777
55MP0002396_abnormal_hematopoietic_system1.31078322
56MP0004510_myositis1.30748490
57MP0000465_gastrointestinal_hemorrhage1.30600465
58MP0000372_irregular_coat_pigmentation1.28387630
59MP0000685_abnormal_immune_system1.28203720
60MP0000920_abnormal_myelination1.27519224
61MP0005464_abnormal_platelet_physiology1.27131134
62MP0005451_abnormal_body_composition1.25817257
63MP0002166_altered_tumor_susceptibility1.25075001
64MP0005584_abnormal_enzyme/coenzyme_acti1.23632715
65MP0000343_altered_response_to1.20643621
66MP0008004_abnormal_stomach_pH1.20421515
67MP0004782_abnormal_surfactant_physiolog1.20391927
68MP0001533_abnormal_skeleton_physiology1.19625431
69MP0008260_abnormal_autophagy1.19416813
70MP0001545_abnormal_hematopoietic_system1.19180041
71MP0005397_hematopoietic_system_phenotyp1.19180041
72MP0000358_abnormal_cell_content/1.18746840
73MP0003448_altered_tumor_morphology1.17960886
74MP0009643_abnormal_urine_homeostasis1.17717344
75MP0002723_abnormal_immune_serum1.17376472
76MP0009697_abnormal_copulation1.16662452
77MP0005083_abnormal_biliary_tract1.16275158
78MP0004957_abnormal_blastocyst_morpholog1.13988506
79MP0002933_joint_inflammation1.12573945
80MP0001216_abnormal_epidermal_layer1.12277389
81MP0002452_abnormal_antigen_presenting1.11834326
82MP0002796_impaired_skin_barrier1.11282949
83MP0005670_abnormal_white_adipose1.11065165
84MP0001666_abnormal_nutrient_absorption1.10445277
85MP0002118_abnormal_lipid_homeostasis1.10066627
86MP0001661_extended_life_span1.09953356
87MP0004381_abnormal_hair_follicle1.09066823
88MP0005166_decreased_susceptibility_to1.07953558
89MP0002420_abnormal_adaptive_immunity1.07843768
90MP0000609_abnormal_liver_physiology1.07343891
91MP0001819_abnormal_immune_cell1.06742476
92MP0009278_abnormal_bone_marrow1.06095136
93MP0005319_abnormal_enzyme/_coenzyme1.05649189
94MP0005164_abnormal_response_to1.04673803
95MP0001845_abnormal_inflammatory_respons1.04557603
96MP0002998_abnormal_bone_remodeling1.04422936
97MP0009763_increased_sensitivity_to1.03718952
98MP0005075_abnormal_melanosome_morpholog1.03047231
99MP0001800_abnormal_humoral_immune1.02919970
100MP0002006_tumorigenesis1.02333925
101MP0004272_abnormal_basement_membrane1.01874544
102MP0001243_abnormal_dermal_layer1.01854513
103MP0009764_decreased_sensitivity_to1.00901259
104MP0005387_immune_system_phenotype0.99020865
105MP0001790_abnormal_immune_system0.99020865
106MP0002876_abnormal_thyroid_physiology0.97635384
107MP0005636_abnormal_mineral_homeostasis0.96265372
108MP0002060_abnormal_skin_morphology0.95697547
109MP0002405_respiratory_system_inflammati0.93608820
110MP0003300_gastrointestinal_ulcer0.92164552
111MP0004185_abnormal_adipocyte_glucose0.91600892
112MP0005376_homeostasis/metabolism_phenot0.91586525
113MP0002254_reproductive_system_inflammat0.91477530
114MP0005501_abnormal_skin_physiology0.91118282
115MP0000858_altered_metastatic_potential0.90890372
116MP0000689_abnormal_spleen_morphology0.90505963
117MP0004947_skin_inflammation0.90186192
118MP0004233_abnormal_muscle_weight0.88662717
119MP0010155_abnormal_intestine_physiology0.88317062
120MP0003786_premature_aging0.88036542
121MP0000490_abnormal_crypts_of0.87510137
122MP0005666_abnormal_adipose_tissue0.87369837
123MP0003763_abnormal_thymus_physiology0.86159239
124MP0001727_abnormal_embryo_implantation0.85681424
125MP0005023_abnormal_wound_healing0.85269502
126MP0000716_abnormal_immune_system0.84239130
127MP0004019_abnormal_vitamin_homeostasis0.83383078
128MP0009765_abnormal_xenobiotic_induced0.81437765
129MP0006035_abnormal_mitochondrial_morpho0.79089361
130MP0008007_abnormal_cellular_replicative0.78838198
131MP0001881_abnormal_mammary_gland0.78761388
132MP0004858_abnormal_nervous_system0.77784648
133MP0002090_abnormal_vision0.75710797
134MP0003795_abnormal_bone_structure0.73895101
135MP0005390_skeleton_phenotype0.71665842
136MP0000371_diluted_coat_color0.68859673
137MP0005330_cardiomyopathy0.68014247
138MP0010771_integument_phenotype0.67508146
139MP0000678_abnormal_parathyroid_gland0.65316808
140MP0005375_adipose_tissue_phenotype0.65086514

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)6.66045132
2Abnormality of glycosphingolipid metabolism (HP:0004343)6.66045132
3Abnormality of glycolipid metabolism (HP:0010969)6.66045132
4Increased cerebral lipofuscin (HP:0011813)4.20056871
5Increased serum pyruvate (HP:0003542)3.97364170
6Abnormality of glycolysis (HP:0004366)3.97364170
7Dysostosis multiplex (HP:0000943)3.93892453
8Loss of speech (HP:0002371)3.65728403
9Increased neuronal autofluorescent lipopigment (HP:0002074)3.57116721
10Hepatic necrosis (HP:0002605)3.56904078
11Axonal loss (HP:0003447)3.53084314
12Vertebral compression fractures (HP:0002953)3.49215401
13Systemic lupus erythematosus (HP:0002725)3.41009872
14Hepatocellular necrosis (HP:0001404)3.31936225
15Mitochondrial inheritance (HP:0001427)3.30156810
16Acute necrotizing encephalopathy (HP:0006965)3.29093405
17Acute encephalopathy (HP:0006846)3.13647815
18Abnormal mitochondria in muscle tissue (HP:0008316)3.10921170
19Nuclear cataract (HP:0100018)3.10881801
20Abnormality of mucopolysaccharide metabolism (HP:0011020)3.05527144
21Abnormality of polysaccharide metabolism (HP:0011012)3.05527144
22Abnormality of glycosaminoglycan metabolism (HP:0004371)3.05527144
23Increased CSF lactate (HP:0002490)3.04187392
24Hypokinesia (HP:0002375)3.01389355
25Abnormality of cells of the erythroid lineage (HP:0012130)3.00222445
26Vacuolated lymphocytes (HP:0001922)2.97785682
27Increased hepatocellular lipid droplets (HP:0006565)2.94998385
28Lipid accumulation in hepatocytes (HP:0006561)2.93264993
29Mucopolysacchariduria (HP:0008155)2.90663884
30Urinary glycosaminoglycan excretion (HP:0003541)2.90663884
31Renal Fanconi syndrome (HP:0001994)2.88362697
32Abnormal number of erythroid precursors (HP:0012131)2.86752130
33Parakeratosis (HP:0001036)2.84505980
34Abnormality of aromatic amino acid family metabolism (HP:0004338)2.84461339
35Abnormal gallbladder physiology (HP:0012438)2.84423018
36Cholecystitis (HP:0001082)2.84423018
373-Methylglutaconic aciduria (HP:0003535)2.83753737
38Progressive neurologic deterioration (HP:0002344)2.80485228
39Hepatosplenomegaly (HP:0001433)2.80088017
40Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.76869021
41Myocardial infarction (HP:0001658)2.72333961
42Abnormality of fatty-acid metabolism (HP:0004359)2.70061121
43Congenital ichthyosiform erythroderma (HP:0007431)2.65327406
44Generalized aminoaciduria (HP:0002909)2.64476850
45Decreased activity of mitochondrial respiratory chain (HP:0008972)2.62816982
46Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.62816982
47Increased muscle lipid content (HP:0009058)2.61654037
48J-shaped sella turcica (HP:0002680)2.61229949
49Cerebral edema (HP:0002181)2.57518869
50Progressive macrocephaly (HP:0004481)2.57443243
51Increased serum lactate (HP:0002151)2.55497085
52Reduced antithrombin III activity (HP:0001976)2.55043150
53Abnormality of dicarboxylic acid metabolism (HP:0010995)2.53495022
54Dicarboxylic aciduria (HP:0003215)2.53495022
55Neurofibrillary tangles (HP:0002185)2.53100812
56Increased intramyocellular lipid droplets (HP:0012240)2.51104854
57Rough bone trabeculation (HP:0100670)2.50731778
58Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.50438556
59Type I transferrin isoform profile (HP:0003642)2.49752948
60Nausea (HP:0002018)2.43013060
61Lactic acidosis (HP:0003128)2.41301306
62Lethargy (HP:0001254)2.33861546
63Hyperlipoproteinemia (HP:0010980)2.32166719
64Aplastic anemia (HP:0001915)2.31394722
65CNS demyelination (HP:0007305)2.29149946
66Hypobetalipoproteinemia (HP:0003563)2.28974615
67Intrahepatic cholestasis (HP:0001406)2.28801545
68Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.27654443
69Respiratory failure (HP:0002878)2.27490957
70Elevated erythrocyte sedimentation rate (HP:0003565)2.27098735
71Cerebral hypomyelination (HP:0006808)2.26653696
72Exertional dyspnea (HP:0002875)2.26404455
73Disinhibition (HP:0000734)2.26146432
74Spastic paraparesis (HP:0002313)2.25892982
75Upper motor neuron abnormality (HP:0002127)2.24809963
76Cerebral inclusion bodies (HP:0100314)2.24164167
77Distal lower limb muscle weakness (HP:0009053)2.23985562
78Ragged-red muscle fibers (HP:0003200)2.22989806
79Reticulocytopenia (HP:0001896)2.22816677
80Steatorrhea (HP:0002570)2.22583979
81Glycosuria (HP:0003076)2.22567616
82Abnormality of urine glucose concentration (HP:0011016)2.22567616
83Prolonged neonatal jaundice (HP:0006579)2.22311317
84Xanthomatosis (HP:0000991)2.22005306
85Poor head control (HP:0002421)2.21894522
86Abnormality of glycine metabolism (HP:0010895)2.21393378
87Abnormality of serine family amino acid metabolism (HP:0010894)2.21393378
88Abnormal trabecular bone morphology (HP:0100671)2.21132819
89Purpura (HP:0000979)2.20865639
90Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.20699065
91Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.20451548
92Diminished motivation (HP:0000745)2.20122901
93Amyloidosis (HP:0011034)2.18393347
94Apathy (HP:0000741)2.18158304
95Methylmalonic aciduria (HP:0012120)2.17721215
96Petechiae (HP:0000967)2.17599100
97Sparse eyelashes (HP:0000653)2.16539004
98Abnormal hemoglobin (HP:0011902)2.15811258
99Macrocytic anemia (HP:0001972)2.15359475
100Abnormality of macrophages (HP:0004311)2.13317507
101Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.11509767
102Abnormality of alanine metabolism (HP:0010916)2.11509767
103Hyperalaninemia (HP:0003348)2.11509767
104Abnormality of the distal phalanges of the toes (HP:0010182)2.11200227
105Prolonged partial thromboplastin time (HP:0003645)2.09244210
106Respiratory difficulties (HP:0002880)2.07793684
107Fasciculations (HP:0002380)2.07176801
108Beaking of vertebral bodies (HP:0004568)2.04127778
109Premature rupture of membranes (HP:0001788)2.03535128
110Mutism (HP:0002300)2.02960422
111Osteolytic defects of the hand bones (HP:0009699)2.00297885
112Osteolytic defects of the phalanges of the hand (HP:0009771)2.00297885
113Interstitial pulmonary disease (HP:0006530)1.99924835
114Cardiomegaly (HP:0001640)1.99850437
115Abnormality of serum amino acid levels (HP:0003112)1.97835678
116Bone pain (HP:0002653)1.96846105
117Pancytopenia (HP:0001876)1.96710359
118Trismus (HP:0000211)1.96394365
119Hyperglycinuria (HP:0003108)1.95824970
120Abnormality of the heme biosynthetic pathway (HP:0010472)1.94349587
121Abnormality of methionine metabolism (HP:0010901)1.94227222
122Hyperglycinemia (HP:0002154)1.93307311
123Fat malabsorption (HP:0002630)1.93062213
124Nonimmune hydrops fetalis (HP:0001790)1.93040850
125Increased serum ferritin (HP:0003281)1.92482869
126Hyperammonemia (HP:0001987)1.92311952
127Exercise intolerance (HP:0003546)1.92238338
128Leukodystrophy (HP:0002415)1.92194908
129Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92136842
130Abnormal protein N-linked glycosylation (HP:0012347)1.92136842
131Abnormal protein glycosylation (HP:0012346)1.92136842
132Abnormal glycosylation (HP:0012345)1.92136842
133Thrombocytosis (HP:0001894)1.91959592
134Opisthotonus (HP:0002179)1.91178059
135Neuronal loss in central nervous system (HP:0002529)1.91030713
136Reduced subcutaneous adipose tissue (HP:0003758)1.90925499
137Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90579342
138Hyperparathyroidism (HP:0000843)1.90474783
139Short nail (HP:0001799)1.90140622
140Congenital, generalized hypertrichosis (HP:0004540)1.89938095
141Recurrent abscess formation (HP:0002722)1.89439437
142Achilles tendon contracture (HP:0001771)1.89325251
143Respiratory distress (HP:0002098)1.88451199
144Personality changes (HP:0000751)1.87312510
145Tetraparesis (HP:0002273)1.87057149
146Autoamputation (HP:0001218)1.85473901
147Distal upper limb amyotrophy (HP:0007149)1.84551172
148Upper limb amyotrophy (HP:0009129)1.84551172
149Eczematoid dermatitis (HP:0000976)1.84255569
150Multiple enchondromatosis (HP:0005701)1.81672723
151Recurrent bacterial skin infections (HP:0005406)1.81039869
152Birth length less than 3rd percentile (HP:0003561)1.80358912
153Abnormality of the Achilles tendon (HP:0005109)1.80072996
154Neoplasm of head and neck (HP:0012288)1.77039567
155Esophageal neoplasm (HP:0100751)1.77039567
156Glomerulonephritis (HP:0000099)1.76105325
157Testicular atrophy (HP:0000029)1.74461892
158Dementia (HP:0000726)1.73550445
159Pathologic fracture (HP:0002756)1.73435863
160Paraparesis (HP:0002385)1.71407258
161Hypertensive crisis (HP:0100735)1.70692802
162Hand muscle atrophy (HP:0009130)1.70567006
163Hypertriglyceridemia (HP:0002155)1.69108681
164Tongue fasciculations (HP:0001308)1.65189588
165Cervical subluxation (HP:0003308)1.63563041
166Chronic obstructive pulmonary disease (HP:0006510)1.62925310
167Obstructive lung disease (HP:0006536)1.62925310
168Abnormality of iron homeostasis (HP:0011031)1.62840064
169Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.60329156
170Multiple lipomas (HP:0001012)1.59801881
171Abnormality of the anterior horn cell (HP:0006802)1.59446264
172Degeneration of anterior horn cells (HP:0002398)1.59446264
173Supranuclear gaze palsy (HP:0000605)1.58467821

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.52833252
2STK163.36943193
3BUB13.17915677
4MST42.98947929
5EIF2AK12.77636153
6PIM22.72862405
7PBK2.71503005
8TESK22.63210426
9BCKDK2.54709698
10VRK22.44367043
11EIF2AK32.44213448
12PAK42.28149333
13KDR1.99858640
14WEE11.99155038
15TRIB31.91912477
16TAOK21.87439691
17MAPKAPK51.81511282
18SCYL21.76097432
19BLK1.71023581
20SMG11.66150401
21MAP4K11.62298630
22VRK11.57024676
23ARAF1.51544748
24ACVR1B1.44072374
25STK391.41355483
26KIT1.41291617
27SIK11.37816880
28LMTK21.33235055
29MYLK1.27993308
30OXSR11.27626849
31TBK11.25578486
32TEC1.23566612
33ZAP701.22808837
34DAPK11.22806378
35IRAK31.22179066
36EPHA21.21013505
37LIMK11.19970614
38BRSK21.19876563
39MAP3K31.18996242
40TYK21.17172466
41ABL21.13713869
42TXK1.12440516
43MAP3K121.06545167
44IKBKE1.06253233
45MAP2K31.05358204
46SIK31.02866616
47IRAK41.02560941
48RIPK41.00402957
49TESK10.99308593
50CDK190.99302494
51LRRK20.98488126
52NME10.95166808
53NEK90.94999626
54MET0.94011169
55PIK3CG0.92265612
56RPS6KB20.91816339
57TGFBR20.90867941
58JAK30.89622760
59ICK0.89339352
60MAPKAPK30.89103690
61PLK40.87180686
62MST1R0.86604407
63IKBKB0.86109712
64PTK20.85101609
65MKNK10.84467853
66CSNK1G30.84364669
67PRPF4B0.83755035
68MUSK0.82673102
69BTK0.82099222
70TSSK60.81630212
71CSF1R0.80042214
72MAP3K10.78495739
73GRK70.78010629
74PDK20.77818589
75DDR20.77412487
76RPS6KA40.76677912
77EIF2AK20.76009719
78BMX0.74826057
79SRPK10.74702476
80STK100.73392045
81MATK0.73090017
82ERBB40.72365761
83TAOK10.71337496
84RPS6KA50.71003344
85MAP3K140.70421203
86TRPM70.69707502
87EPHB20.69672643
88BCR0.69613353
89MAP3K110.67643928
90MAP3K80.67111798
91NEK10.67026801
92RIPK10.66858022
93PKN20.66239916
94TLK10.66215420
95EPHB10.66145586
96TGFBR10.66075470
97ERN10.66003357
98CSNK1G10.65914901
99FGFR40.65760034
100PRKCI0.65481585
101LYN0.63098384
102BMPR1B0.63094705
103DAPK30.62868839
104CAMKK20.60440597
105IRAK20.59774371
106TIE10.57635131
107ZAK0.56239727
108PIM10.55470140
109PDPK10.54983237
110CSNK2A10.54477406
111FER0.54425161
112ILK0.53714763
113LCK0.52844964
114BRAF0.52016167
115CAMK2G0.51961892
116CSNK1A1L0.48807530
117NEK60.48476844
118PDK30.47791527
119PDK40.47791527
120SYK0.47724242
121PAK10.47710997
122MOS0.47419466
123STK40.46691155
124FGR0.46180874
125AURKB0.45881838
126NUAK10.45685691
127CDK80.44626131
128PRKG20.43985044
129CSK0.43934512
130AURKA0.43526648
131CLK10.42292101
132MAPK40.41517416
133MAPKAPK20.40167886
134PTK60.36546530
135TTN0.35433839
136CDC42BPA0.34801158
137CDK70.34151565
138BRSK10.30247346
139AKT20.27102736
140EEF2K0.26921454
141MAP3K130.26302313
142LATS20.25866648
143GSK3A0.25501621
144PRKD30.25049739
145MAPK110.23232033
146ALK0.22874112
147MAP2K60.22388962
148CAMK2D0.21557218
149NTRK10.21424875

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.61334404
2Glycosaminoglycan degradation_Homo sapiens_hsa005313.02929163
3Ribosome_Homo sapiens_hsa030102.98815487
4Fatty acid elongation_Homo sapiens_hsa000622.75729870
5Protein export_Homo sapiens_hsa030602.59581143
6RNA polymerase_Homo sapiens_hsa030202.21720798
7Vibrio cholerae infection_Homo sapiens_hsa051102.21090954
8Caffeine metabolism_Homo sapiens_hsa002322.15969055
9Steroid biosynthesis_Homo sapiens_hsa001002.12695262
10Oxidative phosphorylation_Homo sapiens_hsa001902.06963717
11Galactose metabolism_Homo sapiens_hsa000522.04475437
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.01538443
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.00543546
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.89320541
15Folate biosynthesis_Homo sapiens_hsa007901.84678151
16Collecting duct acid secretion_Homo sapiens_hsa049661.73770402
17DNA replication_Homo sapiens_hsa030301.73504016
18Fructose and mannose metabolism_Homo sapiens_hsa000511.69887094
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.69393229
20Parkinsons disease_Homo sapiens_hsa050121.68776704
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.63411625
22Histidine metabolism_Homo sapiens_hsa003401.61259795
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59894438
24Sulfur metabolism_Homo sapiens_hsa009201.56711045
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.54020567
26Pyrimidine metabolism_Homo sapiens_hsa002401.52694282
27Glutathione metabolism_Homo sapiens_hsa004801.52471090
28Vitamin B6 metabolism_Homo sapiens_hsa007501.49059615
29Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.47321027
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.46201074
31N-Glycan biosynthesis_Homo sapiens_hsa005101.44438362
32Peroxisome_Homo sapiens_hsa041461.42375972
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.41723511
34Propanoate metabolism_Homo sapiens_hsa006401.41364012
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.40886368
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.37375476
37Chemical carcinogenesis_Homo sapiens_hsa052041.36734186
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.35593910
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.32273652
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.31013575
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.29009681
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.27137839
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.26630749
44Mismatch repair_Homo sapiens_hsa034301.22600306
45* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.18991727
46Nucleotide excision repair_Homo sapiens_hsa034201.18578658
47Pentose phosphate pathway_Homo sapiens_hsa000301.18480199
48Fatty acid metabolism_Homo sapiens_hsa012121.18225411
49Fatty acid degradation_Homo sapiens_hsa000711.18087747
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18087557
51Shigellosis_Homo sapiens_hsa051311.17750625
52Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.17734377
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.17256207
54beta-Alanine metabolism_Homo sapiens_hsa004101.11402633
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.11138528
56Salmonella infection_Homo sapiens_hsa051321.10439392
57Pyruvate metabolism_Homo sapiens_hsa006201.10325412
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.06238100
59Huntingtons disease_Homo sapiens_hsa050161.05339305
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05232012
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04048540
62Vitamin digestion and absorption_Homo sapiens_hsa049771.03499683
63Alzheimers disease_Homo sapiens_hsa050101.03051384
64Prion diseases_Homo sapiens_hsa050201.00211689
65Arachidonic acid metabolism_Homo sapiens_hsa005900.99803059
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99729302
67Bladder cancer_Homo sapiens_hsa052190.98523931
68Toll-like receptor signaling pathway_Homo sapiens_hsa046200.97582537
69Staphylococcus aureus infection_Homo sapiens_hsa051500.96439819
70Carbon metabolism_Homo sapiens_hsa012000.94583567
71Other glycan degradation_Homo sapiens_hsa005110.93572026
72Pertussis_Homo sapiens_hsa051330.93334924
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91112494
74Sulfur relay system_Homo sapiens_hsa041220.89894676
75Complement and coagulation cascades_Homo sapiens_hsa046100.88927992
76Lysosome_Homo sapiens_hsa041420.88173813
77Sphingolipid metabolism_Homo sapiens_hsa006000.87142639
78Metabolic pathways_Homo sapiens_hsa011000.86770241
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86164737
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.85710456
81Retinol metabolism_Homo sapiens_hsa008300.85256942
82PPAR signaling pathway_Homo sapiens_hsa033200.85048250
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.84730307
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84323849
85Tuberculosis_Homo sapiens_hsa051520.81226749
86Tryptophan metabolism_Homo sapiens_hsa003800.78655302
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77281831
88Homologous recombination_Homo sapiens_hsa034400.76604371
89Osteoclast differentiation_Homo sapiens_hsa043800.76552703
90Arginine and proline metabolism_Homo sapiens_hsa003300.76210458
912-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75969800
92Butanoate metabolism_Homo sapiens_hsa006500.75011999
93Tyrosine metabolism_Homo sapiens_hsa003500.74507232
94Purine metabolism_Homo sapiens_hsa002300.72320440
95Basal transcription factors_Homo sapiens_hsa030220.71650395
96Non-homologous end-joining_Homo sapiens_hsa034500.71565624
97Phenylalanine metabolism_Homo sapiens_hsa003600.71295171
98One carbon pool by folate_Homo sapiens_hsa006700.69894750
99Apoptosis_Homo sapiens_hsa042100.68105671
100Regulation of autophagy_Homo sapiens_hsa041400.66612377
101Base excision repair_Homo sapiens_hsa034100.66338835
102Spliceosome_Homo sapiens_hsa030400.65535726
103Mineral absorption_Homo sapiens_hsa049780.64905855
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64719943
105Antigen processing and presentation_Homo sapiens_hsa046120.62595964
106Ether lipid metabolism_Homo sapiens_hsa005650.61359223
107Biosynthesis of amino acids_Homo sapiens_hsa012300.60715343
108Linoleic acid metabolism_Homo sapiens_hsa005910.59993523
109NF-kappa B signaling pathway_Homo sapiens_hsa040640.59509673
110Selenocompound metabolism_Homo sapiens_hsa004500.59191701
111Legionellosis_Homo sapiens_hsa051340.58205398
112Malaria_Homo sapiens_hsa051440.57446319
113Leishmaniasis_Homo sapiens_hsa051400.56334668
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55121789
115Primary immunodeficiency_Homo sapiens_hsa053400.54836254
116Synaptic vesicle cycle_Homo sapiens_hsa047210.53547222
117Graft-versus-host disease_Homo sapiens_hsa053320.52930547
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.52015303
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51233432
120Rheumatoid arthritis_Homo sapiens_hsa053230.50974960
121RNA transport_Homo sapiens_hsa030130.50590242
122Renin-angiotensin system_Homo sapiens_hsa046140.50039769
123Endocytosis_Homo sapiens_hsa041440.48539094
124Phagosome_Homo sapiens_hsa041450.48397892
125Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48346631
126Cyanoamino acid metabolism_Homo sapiens_hsa004600.47571309
127TNF signaling pathway_Homo sapiens_hsa046680.46819984
128Hepatitis C_Homo sapiens_hsa051600.46565828
129Hematopoietic cell lineage_Homo sapiens_hsa046400.45096919
130Epstein-Barr virus infection_Homo sapiens_hsa051690.44121546
131Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.43832823
132Fat digestion and absorption_Homo sapiens_hsa049750.39688047
133Glycerolipid metabolism_Homo sapiens_hsa005610.39314240
134Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39115566
135Influenza A_Homo sapiens_hsa051640.37619113
136Toxoplasmosis_Homo sapiens_hsa051450.36912302
137Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.36583362
138Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36487474
139Allograft rejection_Homo sapiens_hsa053300.34058106
140Acute myeloid leukemia_Homo sapiens_hsa052210.33031227
141HIF-1 signaling pathway_Homo sapiens_hsa040660.32314932

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