BCAP31P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-amino acid import (GO:0043092)9.51451944
2embryonic body morphogenesis (GO:0010172)8.55789159
3gamma-aminobutyric acid transport (GO:0015812)7.64230083
4phosphatidylinositol acyl-chain remodeling (GO:0036149)7.51129376
5poly(A)+ mRNA export from nucleus (GO:0016973)7.26120168
6modulation by virus of host process (GO:0019054)7.20910286
7body morphogenesis (GO:0010171)7.18520818
8leukocyte aggregation (GO:0070486)6.96370236
9phosphatidylserine acyl-chain remodeling (GO:0036150)6.76661865
10neurofilament cytoskeleton organization (GO:0060052)6.74707700
11activation of MAPKKK activity (GO:0000185)6.49863210
12amino acid import (GO:0043090)6.27754240
13positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)5.83277355
14modulation by symbiont of host cellular process (GO:0044068)5.62521039
15regulation of translational fidelity (GO:0006450)5.54554340
16neuron fate determination (GO:0048664)5.53459104
17translational termination (GO:0006415)4.89121661
18viral transcription (GO:0019083)4.85239577
19phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.83122305
20amyloid precursor protein catabolic process (GO:0042987)4.77462772
21negative regulation of viral entry into host cell (GO:0046597)4.74593168
22adaptation of signaling pathway (GO:0023058)4.73399343
23ribosomal small subunit assembly (GO:0000028)4.53853170
24neutrophil activation involved in immune response (GO:0002283)4.46168093
25negative regulation of viral release from host cell (GO:1902187)4.44085423
26neutral amino acid transport (GO:0015804)4.44066671
27positive regulation of signal transduction by p53 class mediator (GO:1901798)4.43395124
28skin morphogenesis (GO:0043589)4.42840634
29calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.32846126
30hematopoietic stem cell differentiation (GO:0060218)4.25455991
31N-glycan processing (GO:0006491)4.25153559
32nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.14748345
33phosphatidylcholine acyl-chain remodeling (GO:0036151)4.09298878
34piRNA metabolic process (GO:0034587)4.03375684
35viral life cycle (GO:0019058)4.02551224
36intermediate filament organization (GO:0045109)3.91079356
37glycoprotein catabolic process (GO:0006516)3.86489449
38cellular protein complex disassembly (GO:0043624)3.82503052
39ribosomal small subunit biogenesis (GO:0042274)3.80378018
40translational elongation (GO:0006414)3.71825676
41rRNA transcription (GO:0009303)3.71056614
42phosphatidylserine metabolic process (GO:0006658)3.69626240
43heart valve formation (GO:0003188)3.63353222
44positive regulation of gastrulation (GO:2000543)3.60415977
45SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.57574545
46regulation of transmission of nerve impulse (GO:0051969)3.55928406
47L-amino acid transport (GO:0015807)3.53476893
48cotranslational protein targeting to membrane (GO:0006613)3.52003893
49protein targeting to ER (GO:0045047)3.51985736
50positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.49093737
51response to pheromone (GO:0019236)3.45536604
52negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.42090186
53UV protection (GO:0009650)3.38228403
54induction of positive chemotaxis (GO:0050930)3.36978109
55iron-sulfur cluster assembly (GO:0016226)3.35930591
56metallo-sulfur cluster assembly (GO:0031163)3.35930591
57macrophage activation involved in immune response (GO:0002281)3.34578409
58beta-amyloid metabolic process (GO:0050435)3.33344497
59establishment of protein localization to endoplasmic reticulum (GO:0072599)3.31115462
60protein localization to endoplasmic reticulum (GO:0070972)3.30157645
61regulation of viral entry into host cell (GO:0046596)3.28391145
62protein polyglutamylation (GO:0018095)3.20528081
63protein complex disassembly (GO:0043241)3.05426411
64neuronal action potential propagation (GO:0019227)3.04334768
65antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.03353437
66mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.00531378
67positive regulation of mesonephros development (GO:0061213)2.99478693
68DNA methylation involved in gamete generation (GO:0043046)2.99044357
69regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)2.98421990
70spinal cord development (GO:0021510)2.93629823
71regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.92337870
72regulation of translational elongation (GO:0006448)2.89608809
73negative regulation of receptor activity (GO:2000272)2.89590764
74regulation of viral release from host cell (GO:1902186)2.87884596
75ATP synthesis coupled proton transport (GO:0015986)2.87423044
76energy coupled proton transport, down electrochemical gradient (GO:0015985)2.87423044
77regulation of regulatory T cell differentiation (GO:0045589)2.85179627
78cellular response to pH (GO:0071467)2.83863583
79positive regulation of defense response to virus by host (GO:0002230)2.81487990
80macromolecular complex disassembly (GO:0032984)2.80595835
81alditol phosphate metabolic process (GO:0052646)2.80398028
82negative regulation of potassium ion transport (GO:0043267)2.80240161
83modulation by virus of host morphology or physiology (GO:0019048)2.79719404
84Arp2/3 complex-mediated actin nucleation (GO:0034314)2.72468079
85translational initiation (GO:0006413)2.67902631
86SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)2.67332023
87male meiosis I (GO:0007141)2.63541861
88positive regulation of prostaglandin secretion (GO:0032308)2.61285997
89neurotransmitter secretion (GO:0007269)2.60622997
90positive regulation of protein kinase C signaling (GO:0090037)2.59744650
91rRNA catabolic process (GO:0016075)2.58094010
92dorsal/ventral neural tube patterning (GO:0021904)2.57586451
93regulation of mesonephros development (GO:0061217)2.57471938
94glucocorticoid receptor signaling pathway (GO:0042921)2.53866375
95amyloid precursor protein metabolic process (GO:0042982)2.53728917
96pattern specification involved in kidney development (GO:0061004)2.53514854
97regulation of respiratory burst (GO:0060263)2.50907735
98regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:22.49000516
99negative regulation of protein tyrosine kinase activity (GO:0061099)2.47915947
100glycine transport (GO:0015816)16.6011393

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.78531056
2EZH2_22144423_ChIP-Seq_EOC_Human4.16313954
3EED_16625203_ChIP-ChIP_MESCs_Mouse3.05466714
4EZH2_27304074_Chip-Seq_ESCs_Mouse2.79459056
5IGF1R_20145208_ChIP-Seq_DFB_Human2.76015700
6BMI1_23680149_ChIP-Seq_NPCS_Mouse2.75795701
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.74519865
8CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.67787263
9VDR_22108803_ChIP-Seq_LS180_Human2.60378950
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.51228505
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.42201849
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.38089057
13EZH2_27294783_Chip-Seq_ESCs_Mouse2.37225335
14SUZ12_27294783_Chip-Seq_ESCs_Mouse2.35391175
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.29658539
16CBX2_27304074_Chip-Seq_ESCs_Mouse2.26933339
17RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.21553010
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.16390294
19PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.13324158
20RNF2_18974828_ChIP-Seq_MESCs_Mouse2.02336596
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.02336596
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.95997801
23GBX2_23144817_ChIP-Seq_PC3_Human1.94824744
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.93816340
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.91147781
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90527472
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.88862726
28RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.86989016
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86391758
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85633237
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.85338280
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.80567415
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.72950617
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71111894
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.64973057
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.61120663
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.55962106
38TP53_20018659_ChIP-ChIP_R1E_Mouse1.48362386
39MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.44729249
40RNF2_27304074_Chip-Seq_NSC_Mouse1.44293232
41MTF2_20144788_ChIP-Seq_MESCs_Mouse1.44132606
42TP53_22573176_ChIP-Seq_HFKS_Human1.41825603
43KDM2B_26808549_Chip-Seq_REH_Human1.40131999
44TAF2_19829295_ChIP-Seq_ESCs_Human1.36604442
45FUS_26573619_Chip-Seq_HEK293_Human1.35943754
46ERA_21632823_ChIP-Seq_H3396_Human1.34421814
47REST_21632747_ChIP-Seq_MESCs_Mouse1.30120106
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28326925
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.26245579
50RING1B_27294783_Chip-Seq_ESCs_Mouse1.21494435
51ELF1_20517297_ChIP-Seq_JURKAT_Human1.20563410
52PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.19916079
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18825575
54STAT1_17558387_ChIP-Seq_HELA_Human1.18347789
55TET1_21451524_ChIP-Seq_MESCs_Mouse1.17209968
56ZNF274_21170338_ChIP-Seq_K562_Hela1.16073479
57MYC_19829295_ChIP-Seq_ESCs_Human1.14393578
58STAT1_20625510_ChIP-Seq_HELA_Human1.13198223
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12841307
60AUTS2_25519132_ChIP-Seq_293T-REX_Human1.12699180
61EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11928443
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11496086
63KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10456914
64EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.09589783
65CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.09202430
66AR_20517297_ChIP-Seq_VCAP_Human1.09066696
67DROSHA_22980978_ChIP-Seq_HELA_Human1.09057207
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.08791858
69EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02109332
70P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99461902
71SMC3_22415368_ChIP-Seq_MEFs_Mouse0.98958644
72SA1_27219007_Chip-Seq_Bcells_Human0.97652779
73RING1B_27294783_Chip-Seq_NPCs_Mouse0.93809129
74BP1_19119308_ChIP-ChIP_Hs578T_Human0.92516673
75EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91117251
76OCT1_27270436_Chip-Seq_PROSTATE_Human0.90568463
77KAP1_22055183_ChIP-Seq_ESCs_Mouse0.90148391
78CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89462151
79GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.88929775
80P53_21459846_ChIP-Seq_SAOS-2_Human0.88554298
81TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87568209
82OCT4_19829295_ChIP-Seq_ESCs_Human0.86865716
83RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.86656764
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.86235177
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85787591
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.85787591
87PIAS1_25552417_ChIP-Seq_VCAP_Human0.85041475
88REST_18959480_ChIP-ChIP_MESCs_Mouse0.84559363
89SOX11_22085726_ChIP-Seq_ESNs_Mouse0.83896205
90SMAD3_21741376_ChIP-Seq_ESCs_Human0.82302939
91AR_21572438_ChIP-Seq_LNCaP_Human0.81635846
92PRDM14_20953172_ChIP-Seq_ESCs_Human0.81604169
93TRIM28_21343339_ChIP-Seq_HEK293_Human0.81403919
94PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.81231890
95FOXA1_25329375_ChIP-Seq_VCAP_Human0.80891514
96FOXA1_27270436_Chip-Seq_PROSTATE_Human0.80891514
97JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.80825899
98CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80578802
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80502129
100TCF4_22108803_ChIP-Seq_LS180_Human0.80464577

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000013_abnormal_adipose_tissue6.51835577
2MP0006054_spinal_hemorrhage5.22924794
3MP0005623_abnormal_meninges_morphology5.07360875
4MP0003136_yellow_coat_color5.02717142
5MP0004142_abnormal_muscle_tone4.90129356
6MP0003385_abnormal_body_wall4.51179709
7MP0000750_abnormal_muscle_regeneration3.56246005
8MP0003646_muscle_fatigue3.12749294
9MP0002138_abnormal_hepatobiliary_system2.70299748
10MP0004145_abnormal_muscle_electrophysio2.55500743
11MP0001486_abnormal_startle_reflex2.34390840
12MP0002938_white_spotting2.31281948
13MP0003329_amyloid_beta_deposits2.07388174
14MP0000003_abnormal_adipose_tissue2.04854729
15MP0001188_hyperpigmentation1.99638333
16MP0009379_abnormal_foot_pigmentation1.96028035
17MP0005503_abnormal_tendon_morphology1.88001227
18MP0003567_abnormal_fetal_cardiomyocyte1.83467863
19MP0009384_cardiac_valve_regurgitation1.82537433
20MP0005171_absent_coat_pigmentation1.80971687
21MP0001727_abnormal_embryo_implantation1.72493931
22MP0009250_abnormal_appendicular_skeleto1.71558315
23MP0003786_premature_aging1.56137644
24MP0001984_abnormal_olfaction1.54619838
25MP0004381_abnormal_hair_follicle1.50455897
26MP0003283_abnormal_digestive_organ1.37770534
27MP0001324_abnormal_eye_pigmentation1.37439730
28MP0009697_abnormal_copulation1.34344631
29MP0005369_muscle_phenotype1.33895501
30MP0000604_amyloidosis1.33744088
31MP0004134_abnormal_chest_morphology1.32334613
32MP0000762_abnormal_tongue_morphology1.29472247
33MP0005174_abnormal_tail_pigmentation1.28250929
34MP0002106_abnormal_muscle_physiology1.27890373
35MP0002653_abnormal_ependyma_morphology1.26642336
36MP0005551_abnormal_eye_electrophysiolog1.26252905
37MP0005671_abnormal_response_to1.25420903
38MP0002089_abnormal_postnatal_growth/wei1.24903564
39MP0002272_abnormal_nervous_system1.23421969
40MP0003137_abnormal_impulse_conducting1.23362730
41MP0002177_abnormal_outer_ear1.19766189
42MP0004147_increased_porphyrin_level1.14821910
43MP0004858_abnormal_nervous_system1.11882190
44MP0002067_abnormal_sensory_capabilities1.11302330
45MP0000955_abnormal_spinal_cord1.11082368
46MP0002734_abnormal_mechanical_nocicepti1.10667033
47MP0000751_myopathy1.09968094
48MP0000749_muscle_degeneration1.09954058
49MP0004947_skin_inflammation1.06692436
50MP0000647_abnormal_sebaceous_gland1.05851307
51MP0002108_abnormal_muscle_morphology1.03645234
52MP0002269_muscular_atrophy1.01620133
53MP0002837_dystrophic_cardiac_calcinosis1.01087850
54MP0004215_abnormal_myocardial_fiber0.88993044
55MP0004885_abnormal_endolymph0.88766769
56MP0004087_abnormal_muscle_fiber0.86977493
57MP0001986_abnormal_taste_sensitivity0.85488199
58MP0002277_abnormal_respiratory_mucosa0.85397991
59MP0002095_abnormal_skin_pigmentation0.82849477
60MP0003635_abnormal_synaptic_transmissio0.82358110
61MP0008872_abnormal_physiological_respon0.82251164
62MP0000613_abnormal_salivary_gland0.80894751
63MP0005360_urolithiasis0.80470273
64MP0002163_abnormal_gland_morphology0.79276025
65MP0009053_abnormal_anal_canal0.78201279
66MP0001915_intracranial_hemorrhage0.77724633
67MP0008775_abnormal_heart_ventricle0.77076532
68MP0000759_abnormal_skeletal_muscle0.76220945
69MP0000372_irregular_coat_pigmentation0.75763486
70MP0004133_heterotaxia0.72416722
71MP0005375_adipose_tissue_phenotype0.72381167
72MP0002638_abnormal_pupillary_reflex0.71915981
73MP0005423_abnormal_somatic_nervous0.71774154
74MP0009046_muscle_twitch0.71429231
75MP0003436_decreased_susceptibility_to0.70947380
76MP0001968_abnormal_touch/_nociception0.69543204
77MP0001348_abnormal_lacrimal_gland0.68455558
78MP0000467_abnormal_esophagus_morphology0.68276853
79MP0009745_abnormal_behavioral_response0.68143572
80MP0000377_abnormal_hair_follicle0.67587078
81MP0001299_abnormal_eye_distance/0.66855678
82MP0003868_abnormal_feces_composition0.65934663
83MP0003115_abnormal_respiratory_system0.65858970
84MP0005195_abnormal_posterior_eye0.60585827
85MP0002160_abnormal_reproductive_system0.59385441
86MP0008995_early_reproductive_senescence0.57708897
87MP0001542_abnormal_bone_strength0.57122837
88MP0003011_delayed_dark_adaptation0.56005425
89MP0005193_abnormal_anterior_eye0.55659904
90MP0003755_abnormal_palate_morphology0.55178951
91MP0003633_abnormal_nervous_system0.53134161
92MP0009785_altered_susceptibility_to0.53059990
93MP0002752_abnormal_somatic_nervous0.53025638
94MP0000778_abnormal_nervous_system0.53017731
95MP0003195_calcinosis0.52379710
96MP0004130_abnormal_muscle_cell0.52293350
97MP0003936_abnormal_reproductive_system0.52280519
98MP0001879_abnormal_lymphatic_vessel0.49133813
99MP0002066_abnormal_motor_capabilities/c0.48684037
100MP0000858_altered_metastatic_potential0.46290679

Predicted human phenotypes

RankGene SetZ-score
1Cerebellar dysplasia (HP:0007033)8.79886347
2Retinal atrophy (HP:0001105)8.70694274
3Type II lissencephaly (HP:0007260)8.57348659
4Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)8.50055679
5Agnosia (HP:0010524)7.82256665
6Retinal dysplasia (HP:0007973)7.41997768
7Muscle stiffness (HP:0003552)5.79129886
8Disinhibition (HP:0000734)5.29259543
9Hypoplasia of the pons (HP:0012110)5.08741147
10Lower limb hyperreflexia (HP:0002395)5.02427773
11Abnormality of the pons (HP:0007361)4.89434028
12Fatigue (HP:0012378)4.30365903
13Aplasia/Hypoplasia affecting the retina (HP:0008061)4.06197749
14Personality changes (HP:0000751)3.98283298
15Difficulty climbing stairs (HP:0003551)3.89988358
16Lissencephaly (HP:0001339)3.75788922
17Neck muscle weakness (HP:0000467)3.65926083
18Buphthalmos (HP:0000557)3.58454451
19Severe muscular hypotonia (HP:0006829)3.56434126
20Decreased electroretinogram (ERG) amplitude (HP:0000654)3.54406403
21Inappropriate behavior (HP:0000719)3.45877477
22Axonal loss (HP:0003447)3.39272160
23Increased IgM level (HP:0003496)3.36202448
24Upper motor neuron abnormality (HP:0002127)3.29907438
25Mask-like facies (HP:0000298)3.24404954
26Progressive external ophthalmoplegia (HP:0000590)3.18600920
27Abolished electroretinogram (ERG) (HP:0000550)3.13337412
28Abnormality of the vitreous humor (HP:0004327)3.01965053
29Neurofibrillary tangles (HP:0002185)2.99884335
30Abnormality of DNA repair (HP:0003254)2.98173957
31Poikiloderma (HP:0001029)2.91038412
32Entropion (HP:0000621)2.89977227
33Amyotrophic lateral sclerosis (HP:0007354)2.74319917
34Flat capital femoral epiphysis (HP:0003370)2.71359745
35Pachygyria (HP:0001302)2.55155590
36Concave nail (HP:0001598)2.55085310
37Muscle fiber inclusion bodies (HP:0100299)2.54573031
38Spastic tetraparesis (HP:0001285)2.50601682
39Nemaline bodies (HP:0003798)2.49183706
40IgG deficiency (HP:0004315)2.47790963
41Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.41824789
42True hermaphroditism (HP:0010459)2.31281816
43Abnormality of cells of the erythroid lineage (HP:0012130)2.29404102
44Generalized muscle weakness (HP:0003324)2.23721577
45Muscle hypertrophy of the lower extremities (HP:0008968)2.16685731
46Memory impairment (HP:0002354)2.14814456
47Polyphagia (HP:0002591)2.14439904
48Abnormality of the right ventricle (HP:0001707)2.13773140
49Non-midline cleft lip (HP:0100335)2.11956466
50Pallor (HP:0000980)2.09185677
51Calf muscle hypertrophy (HP:0008981)2.08662611
52Megalocornea (HP:0000485)2.08169914
53Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.07857058
54Meningocele (HP:0002435)2.03922101
55Pancreatic fibrosis (HP:0100732)2.03403041
56Sclerocornea (HP:0000647)2.02337309
57Abnormality of transition element cation homeostasis (HP:0011030)1.99871051
58Chronic hepatic failure (HP:0100626)1.99093653
59Hepatitis (HP:0012115)1.98901286
60Congenital, generalized hypertrichosis (HP:0004540)1.91491981
61Abnormality of midbrain morphology (HP:0002418)1.90390860
62Molar tooth sign on MRI (HP:0002419)1.90390860
63Basal ganglia calcification (HP:0002135)1.89441204
64CNS hypomyelination (HP:0003429)1.89204867
65Congenital glaucoma (HP:0001087)1.88327231
66Gowers sign (HP:0003391)1.85513512
67Patellar aplasia (HP:0006443)1.83087500
68Aplasia/Hypoplasia of the brainstem (HP:0007362)1.82419329
69Hypoplasia of the brainstem (HP:0002365)1.82419329
70Abnormality of the motor neurons (HP:0002450)1.80075646
71Abnormal neuron morphology (HP:0012757)1.80075646
72Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.80017475
73Decreased circulating renin level (HP:0003351)1.79595731
74Absent phalangeal crease (HP:0006109)1.78718323
75Nephropathy (HP:0000112)1.78026349
76Absent thumb (HP:0009777)1.74192048
77Aplasia/Hypoplasia of the patella (HP:0006498)1.72767905
78Polymicrogyria (HP:0002126)1.69431388
79Bone cyst (HP:0012062)1.68055326
80Subacute progressive viral hepatitis (HP:0006572)1.67144606
81Hypoplasia of the uterus (HP:0000013)1.64627150
82Type 1 muscle fiber predominance (HP:0003803)1.63445110
83Mesangial abnormality (HP:0001966)1.63376329
84Muscular dystrophy (HP:0003560)1.63231437
85Metabolic alkalosis (HP:0200114)1.62906942
86Reticulocytopenia (HP:0001896)1.61089416
87Fragile nails (HP:0001808)1.59435928
88Nephrogenic diabetes insipidus (HP:0009806)1.58449312
89Abnormal finger flexion creases (HP:0006143)1.58373762
90Cerebral inclusion bodies (HP:0100314)1.56991391
91Focal motor seizures (HP:0011153)1.55749997
92Dandy-Walker malformation (HP:0001305)1.54541601
93Sacral dimple (HP:0000960)1.54119724
94Synostosis of carpal bones (HP:0005048)1.53708302
95Recurrent bacterial skin infections (HP:0005406)1.49998102
96Encephalitis (HP:0002383)1.49135461
97Syncope (HP:0001279)1.48204220
98Hypoplasia of the radius (HP:0002984)1.47782424
99Papilledema (HP:0001085)1.47403644
100Conjugated hyperbilirubinemia (HP:0002908)1.45907324

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK34.68588638
2ARAF4.61080128
3STK104.47981104
4BCKDK4.42228942
5MAP3K133.88260378
6MAP3K93.39871525
7TNIK2.48711310
8SCYL22.45304084
9OBSCN2.40153202
10EIF2AK12.17763424
11PTK2B2.12955956
12WNK42.12467500
13MOS2.09070382
14TIE11.92601135
15MINK11.91605800
16PIM11.85914565
17MAP3K41.65402252
18PHKG21.54935563
19PHKG11.54935563
20DYRK1A1.53889034
21EEF2K1.44073953
22EPHA31.42621987
23MAPKAPK31.35921216
24TXK1.35380847
25STK111.34828337
26WNK11.33728904
27MAP2K41.31278877
28GRK11.19302357
29RPS6KB21.17114111
30NEK21.12985381
31TRPM71.12665588
32TYRO31.10660050
33MAPK131.09945372
34BRAF1.07376977
35STK391.01507053
36MAP2K60.98606221
37CDC42BPA0.94113477
38MARK10.92915256
39SYK0.90371642
40BRD40.89551689
41LMTK20.88400370
42NLK0.87034726
43PRKCH0.85899838
44MAPK120.84774599
45DYRK20.83775604
46MATK0.81995320
47CSNK1D0.78619896
48MAP3K10.78249953
49PNCK0.75548414
50PIM20.75420688
51MAPKAPK50.74733130
52CSNK2A20.74197778
53MAPK150.73245959
54NTRK20.69430359
55CDK150.66126883
56CDK11A0.62946825
57WEE10.62681514
58TTN0.61943574
59CSNK1G30.61527539
60PRKCG0.60717282
61MAP2K70.60491770
62CDK180.57408225
63CSNK1A10.56361727
64CDC70.55176112
65UHMK10.54813561
66NEK90.54198258
67CSNK1G10.53762206
68FRK0.53052829
69GRK70.52416668
70INSRR0.51385469
71MAP2K20.50845369
72BMPR1B0.50512322
73ADRBK20.49614027
74MUSK0.47059133
75WNK30.45798084
76PRKCI0.43230438
77PRKCQ0.43130555
78PIK3CG0.43128210
79CDK190.42623115
80KIT0.42370754
81ADRBK10.41734254
82PRKCA0.40684173
83LCK0.39275448
84PRKCE0.38401303
85PRKACA0.37435795
86CSNK1A1L0.36698525
87CDK140.35766103
88MAP4K20.34640686
89MAPK70.33564820
90CDK50.32596799
91SIK20.32501604
92NEK10.32068476
93PIK3CA0.31078282
94CSNK1G20.29343211
95FGFR10.28934695
96RAF10.28108588
97CSNK1E0.26369792
98CAMK2G0.26334610
99PAK30.26240700
100MST1R0.25157372

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.87636256
2Linoleic acid metabolism_Homo sapiens_hsa005914.62665880
3Sulfur relay system_Homo sapiens_hsa041224.52202598
4Ribosome_Homo sapiens_hsa030103.68863753
5Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.42461421
6Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.80058426
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.79307433
8Cardiac muscle contraction_Homo sapiens_hsa042602.76103192
9Ether lipid metabolism_Homo sapiens_hsa005652.66615203
10Oxidative phosphorylation_Homo sapiens_hsa001902.59966317
11Nitrogen metabolism_Homo sapiens_hsa009102.38894728
12Nicotine addiction_Homo sapiens_hsa050332.26286399
13Parkinsons disease_Homo sapiens_hsa050122.05413464
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.87342514
15Graft-versus-host disease_Homo sapiens_hsa053321.73075911
16Huntingtons disease_Homo sapiens_hsa050161.71914830
17Alzheimers disease_Homo sapiens_hsa050101.71758550
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.69745873
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.57633564
20SNARE interactions in vesicular transport_Homo sapiens_hsa041301.55324449
21Allograft rejection_Homo sapiens_hsa053301.48345709
22Autoimmune thyroid disease_Homo sapiens_hsa053201.42212904
23Arachidonic acid metabolism_Homo sapiens_hsa005901.40620000
24Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.38115026
25Caffeine metabolism_Homo sapiens_hsa002321.35284127
26Regulation of autophagy_Homo sapiens_hsa041401.33673659
27Type I diabetes mellitus_Homo sapiens_hsa049401.28083035
28Sulfur metabolism_Homo sapiens_hsa009201.27427074
29Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.27267393
30mRNA surveillance pathway_Homo sapiens_hsa030151.25950513
31Morphine addiction_Homo sapiens_hsa050321.16570428
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.03855638
33GABAergic synapse_Homo sapiens_hsa047270.98164633
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97400794
35Cysteine and methionine metabolism_Homo sapiens_hsa002700.97132140
36Phototransduction_Homo sapiens_hsa047440.90552758
37NF-kappa B signaling pathway_Homo sapiens_hsa040640.90453107
38Phenylalanine metabolism_Homo sapiens_hsa003600.86653637
39Antigen processing and presentation_Homo sapiens_hsa046120.81811937
40Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79254577
41RNA polymerase_Homo sapiens_hsa030200.77363279
42Viral myocarditis_Homo sapiens_hsa054160.76986544
43Fanconi anemia pathway_Homo sapiens_hsa034600.76434646
44Propanoate metabolism_Homo sapiens_hsa006400.75942787
45Glycerophospholipid metabolism_Homo sapiens_hsa005640.75627882
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74145765
47Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.73215230
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72320154
49NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64758555
50Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64431602
51Synaptic vesicle cycle_Homo sapiens_hsa047210.59305260
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.59302463
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.56153497
54Ras signaling pathway_Homo sapiens_hsa040140.55246652
55Primary immunodeficiency_Homo sapiens_hsa053400.55239285
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54720114
57Dilated cardiomyopathy_Homo sapiens_hsa054140.54629425
58Dorso-ventral axis formation_Homo sapiens_hsa043200.53479260
59Asthma_Homo sapiens_hsa053100.52583879
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52293595
61Nucleotide excision repair_Homo sapiens_hsa034200.50977967
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.49218409
63TNF signaling pathway_Homo sapiens_hsa046680.48006879
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47638850
65Chemical carcinogenesis_Homo sapiens_hsa052040.46768662
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43656731
67Toll-like receptor signaling pathway_Homo sapiens_hsa046200.42777872
68MAPK signaling pathway_Homo sapiens_hsa040100.41673169
69Osteoclast differentiation_Homo sapiens_hsa043800.41595020
70Hematopoietic cell lineage_Homo sapiens_hsa046400.40756110
71Rheumatoid arthritis_Homo sapiens_hsa053230.39773837
72Leishmaniasis_Homo sapiens_hsa051400.37222786
73Collecting duct acid secretion_Homo sapiens_hsa049660.36855232
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35249810
75Glycosaminoglycan degradation_Homo sapiens_hsa005310.35151261
76Insulin secretion_Homo sapiens_hsa049110.33977814
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31636537
78Tryptophan metabolism_Homo sapiens_hsa003800.30245624
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.29866573
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.25478588
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25120263
82Oxytocin signaling pathway_Homo sapiens_hsa049210.25009140
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24778126
84Metabolic pathways_Homo sapiens_hsa011000.23594814
85Cholinergic synapse_Homo sapiens_hsa047250.23293985
86Olfactory transduction_Homo sapiens_hsa047400.23261161
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.22174986
88RNA transport_Homo sapiens_hsa030130.21953420
89Toxoplasmosis_Homo sapiens_hsa051450.21576494
90Epstein-Barr virus infection_Homo sapiens_hsa051690.21358964
91Mineral absorption_Homo sapiens_hsa049780.20537698
92Salivary secretion_Homo sapiens_hsa049700.20247692
93Amphetamine addiction_Homo sapiens_hsa050310.18866872
94Proteasome_Homo sapiens_hsa030500.16860528
95Serotonergic synapse_Homo sapiens_hsa047260.16644981
96Cocaine addiction_Homo sapiens_hsa050300.15434992
97Fat digestion and absorption_Homo sapiens_hsa049750.13777237
98Purine metabolism_Homo sapiens_hsa002300.13284810
99Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.12934457
100Tyrosine metabolism_Homo sapiens_hsa003500.12871087

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