BCAR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006 [PubMed 17129785]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)4.26140606
2polarized epithelial cell differentiation (GO:0030859)4.05497853
3desmosome organization (GO:0002934)3.69675430
4atrioventricular valve morphogenesis (GO:0003181)3.65460483
5cytoskeletal anchoring at plasma membrane (GO:0007016)3.60509676
6regulation of hippo signaling (GO:0035330)3.53869561
7COPI coating of Golgi vesicle (GO:0048205)3.34061307
8Golgi transport vesicle coating (GO:0048200)3.34061307
9apical protein localization (GO:0045176)3.18003774
10activation of Rac GTPase activity (GO:0032863)3.15348031
11endocardial cushion development (GO:0003197)3.12964149
12hippo signaling (GO:0035329)3.07879709
13negative regulation of chondrocyte differentiation (GO:0032331)3.06617760
14establishment of apical/basal cell polarity (GO:0035089)3.04653522
15vascular endothelial growth factor signaling pathway (GO:0038084)3.04071904
16dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.99604831
17negative regulation of catenin import into nucleus (GO:0035414)2.97204986
18epithelial cell-cell adhesion (GO:0090136)2.93698564
19Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.92524507
20plasma membrane repair (GO:0001778)2.91125051
21regulation of posttranscriptional gene silencing (GO:0060147)2.91123520
22regulation of gene silencing by miRNA (GO:0060964)2.91123520
23regulation of gene silencing by RNA (GO:0060966)2.91123520
24establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.91090609
25positive regulation of osteoblast proliferation (GO:0033690)2.89877615
26paraxial mesoderm development (GO:0048339)2.89784913
27convergent extension (GO:0060026)2.88171815
28retina vasculature morphogenesis in camera-type eye (GO:0061299)2.87012514
29endothelial cell chemotaxis (GO:0035767)2.86537414
30positive regulation of blood vessel endothelial cell migration (GO:0043536)2.84877480
31regulation of cholesterol homeostasis (GO:2000188)2.83121441
32adherens junction assembly (GO:0034333)2.81762058
33regulation of establishment of planar polarity (GO:0090175)2.75457911
34chondrocyte proliferation (GO:0035988)2.75174798
35apoptotic process involved in morphogenesis (GO:0060561)2.71718438
36basement membrane organization (GO:0071711)2.71399245
37establishment of monopolar cell polarity (GO:0061162)2.67868978
38establishment or maintenance of monopolar cell polarity (GO:0061339)2.67868978
39regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.66892074
40negative regulation of cell size (GO:0045792)2.66600772
41regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.64464600
42cell junction maintenance (GO:0034331)2.63238253
43maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.62050217
44negative regulation of fibrinolysis (GO:0051918)2.60398127
45activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.59641636
46gap junction assembly (GO:0016264)2.59243490
47branching involved in mammary gland duct morphogenesis (GO:0060444)2.58965554
48cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.57603068
49planar cell polarity pathway involved in neural tube closure (GO:0090179)2.57259166
50mesodermal cell differentiation (GO:0048333)2.55936118
51regulation of glucose import in response to insulin stimulus (GO:2001273)2.53513462
52synaptic vesicle docking involved in exocytosis (GO:0016081)2.52598331
53cell migration involved in sprouting angiogenesis (GO:0002042)2.52565084
54anterior/posterior axis specification, embryo (GO:0008595)2.52243638
55endocytic recycling (GO:0032456)2.51799040
56* vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.51750644
57protein retention in ER lumen (GO:0006621)2.49533249
58stress fiber assembly (GO:0043149)2.48386269
59cell-cell junction maintenance (GO:0045217)2.45469123
60neural tube development (GO:0021915)2.44945302
614-hydroxyproline metabolic process (GO:0019471)2.44718104
62regulation of catenin import into nucleus (GO:0035412)2.43928399
63substrate-dependent cell migration (GO:0006929)2.42783936
64regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.41818212
65positive regulation of nuclease activity (GO:0032075)2.41301442
66renal filtration (GO:0097205)2.41007702
67positive regulation of receptor recycling (GO:0001921)2.40457449
68negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.39854656
69actin filament bundle organization (GO:0061572)2.38947260
70actin filament bundle assembly (GO:0051017)2.38947260
71regulation of mammary gland epithelial cell proliferation (GO:0033599)2.38880914
72positive regulation of endothelial cell apoptotic process (GO:2000353)2.38457727
73asymmetric protein localization (GO:0008105)2.37329842
74peripheral nervous system axon ensheathment (GO:0032292)2.36529084
75myelination in peripheral nervous system (GO:0022011)2.36529084
76bone trabecula formation (GO:0060346)2.34926065
77collecting duct development (GO:0072044)2.34731718
78non-canonical Wnt signaling pathway (GO:0035567)2.34699530
79regulation of early endosome to late endosome transport (GO:2000641)2.34064718
80lymphangiogenesis (GO:0001946)2.33863218
81barbed-end actin filament capping (GO:0051016)2.32151779
82establishment or maintenance of bipolar cell polarity (GO:0061245)2.32107214
83establishment or maintenance of apical/basal cell polarity (GO:0035088)2.32107214
84cell migration involved in heart development (GO:0060973)2.31883854
85regulation of apoptotic process involved in morphogenesis (GO:1902337)2.30924806
86notochord development (GO:0030903)2.30849889
87collagen metabolic process (GO:0032963)2.30603728
88wound healing, spreading of epidermal cells (GO:0035313)2.30532399
89regulation of extracellular matrix disassembly (GO:0010715)2.30388968
90cerebellar Purkinje cell layer development (GO:0021680)2.30358441
91G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.29386893
92regulation of cardioblast differentiation (GO:0051890)2.29181538
93skin morphogenesis (GO:0043589)2.28767768
94endothelial cell morphogenesis (GO:0001886)2.26733363
95COPII vesicle coating (GO:0048208)2.26268697
96cell adhesion mediated by integrin (GO:0033627)2.26230521
97kidney mesenchyme development (GO:0072074)2.25707314
98negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.25329065
99cell-cell junction assembly (GO:0007043)2.25275725
100eye morphogenesis (GO:0048592)2.24992948
101negative regulation of cartilage development (GO:0061037)2.24949885
102actin filament depolymerization (GO:0030042)2.24524091
103regulation of tight junction assembly (GO:2000810)2.24371448
104insulin-like growth factor receptor signaling pathway (GO:0048009)2.23995436
105blood vessel endothelial cell migration (GO:0043534)2.23897469
106apoptotic cell clearance (GO:0043277)2.23621330
107cell volume homeostasis (GO:0006884)2.23392789
108muscle cell migration (GO:0014812)2.22965892
109wound healing, spreading of cells (GO:0044319)2.21602272
110ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.21227290
111cell-substrate junction assembly (GO:0007044)2.20974824
112protein heterotrimerization (GO:0070208)2.20633358
113embryonic foregut morphogenesis (GO:0048617)2.20047040
114cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.19806651
115erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.18891717
116L-phenylalanine metabolic process (GO:0006558)2.18891717
117endodermal cell differentiation (GO:0035987)2.17769289
118focal adhesion assembly (GO:0048041)2.17473711
119cell-substrate adherens junction assembly (GO:0007045)2.17473711
120branching involved in salivary gland morphogenesis (GO:0060445)2.17074162
121regulation of p38MAPK cascade (GO:1900744)2.16069702
122adherens junction organization (GO:0034332)2.14642722
123gonadal mesoderm development (GO:0007506)2.14626090
124negative regulation of fatty acid transport (GO:2000192)2.14247509
125positive regulation of glycogen biosynthetic process (GO:0045725)2.13888005
126semaphorin-plexin signaling pathway (GO:0071526)2.13309227
127L-phenylalanine catabolic process (GO:0006559)2.12201497
128erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.12201497
129endoplasmic reticulum unfolded protein response (GO:0030968)2.11348736
130body morphogenesis (GO:0010171)2.11075295
131retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.10316015
132camera-type eye morphogenesis (GO:0048593)2.09325620
133regulation of nuclease activity (GO:0032069)2.09294462
134cell junction assembly (GO:0034329)2.09234134
135protein localization to endosome (GO:0036010)2.08665975
136tight junction assembly (GO:0070830)2.08487147
137positive regulation of catenin import into nucleus (GO:0035413)2.08126059
138midgut development (GO:0007494)2.07983738
139collagen fibril organization (GO:0030199)2.07681465
140protein targeting to plasma membrane (GO:0072661)2.07621764
141intestinal cholesterol absorption (GO:0030299)2.06625311
142layer formation in cerebral cortex (GO:0021819)2.06486867
143epithelial cell fate commitment (GO:0072148)2.05393343
144peptidyl-tyrosine autophosphorylation (GO:0038083)2.05348694
145lens fiber cell development (GO:0070307)2.04559782
146L-alpha-amino acid transmembrane transport (GO:1902475)2.04233398
147cochlea morphogenesis (GO:0090103)2.03853518

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.96470432
2TRIM28_21343339_ChIP-Seq_HEK293_Human2.87984791
3RARG_19884340_ChIP-ChIP_MEFs_Mouse2.80046923
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.60316580
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.38398846
6CLOCK_20551151_ChIP-Seq_293T_Human2.33838125
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.30049704
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.26356708
9EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.17387154
10* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.16094673
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.06783252
12SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.03255813
13ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.95899887
14WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.94850073
15EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.84962204
16ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.82870086
17ESR2_21235772_ChIP-Seq_MCF-7_Human1.81053990
18* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.69611446
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.66602466
20* RXR_22158963_ChIP-Seq_LIVER_Mouse1.66600415
21ERG_21242973_ChIP-ChIP_JURKAT_Human1.63917459
22* KDM2B_26808549_Chip-Seq_K562_Human1.62984036
23* RACK7_27058665_Chip-Seq_MCF-7_Human1.55595509
24PPARA_22158963_ChIP-Seq_LIVER_Mouse1.55578609
25ZFP281_27345836_Chip-Seq_ESCs_Mouse1.54742196
26TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51389007
27LXR_22158963_ChIP-Seq_LIVER_Mouse1.50326754
28P300_27058665_Chip-Seq_ZR-75-30cells_Human1.49942949
29PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.49772018
30* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.49666015
31* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.48875274
32* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.45913298
33LXR_22292898_ChIP-Seq_THP-1_Human1.44555620
34POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.44376380
35* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.43683044
36HIF1A_21447827_ChIP-Seq_MCF-7_Human1.43612522
37TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42404288
38TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.41373767
39TET1_21451524_ChIP-Seq_MESCs_Mouse1.40112440
40ESR1_21235772_ChIP-Seq_MCF-7_Human1.38014413
41* EP300_21415370_ChIP-Seq_HL-1_Mouse1.36739759
42SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.35970055
43* ATF3_27146783_Chip-Seq_COLON_Human1.33933306
44ELK3_25401928_ChIP-Seq_HUVEC_Human1.33492419
45* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.33058883
46* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.33054252
47ISL1_27105846_Chip-Seq_CPCs_Mouse1.32718679
48ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.32638037
49CREB1_26743006_Chip-Seq_LNCaP_Human1.32613654
50TP53_20018659_ChIP-ChIP_R1E_Mouse1.32283983
51CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.31538812
52* TCF7_22412390_ChIP-Seq_EML_Mouse1.30964810
53TCF3_18692474_ChIP-Seq_MEFs_Mouse1.29814407
54ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.28923410
55ZNF263_19887448_ChIP-Seq_K562_Human1.28811460
56UBF1/2_26484160_Chip-Seq_HMECs_Human1.27468341
57SMC4_20622854_ChIP-Seq_HELA_Human1.26679828
58DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.25683427
59MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.24597871
60ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23454439
61PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.23433332
62RNF2_18974828_ChIP-Seq_MESCs_Mouse1.23169336
63EZH2_18974828_ChIP-Seq_MESCs_Mouse1.23169336
64DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23126185
65* RUNX1_27514584_Chip-Seq_MCF-7_Human1.22500978
66TP53_22127205_ChIP-Seq_IMR90_Human1.22396987
67* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22278418
68* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21790169
69KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.19917554
70KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.19917554
71KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.19917554
72P68_20966046_ChIP-Seq_HELA_Human1.19826220
73SOX9_24532713_ChIP-Seq_HFSC_Mouse1.19570695
74SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.18448518
75NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.17657657
76KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17389941
77SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16662281
78ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16661550
79KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16629382
80* TP53_23651856_ChIP-Seq_MEFs_Mouse1.16460014
81CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16388705
82DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15836733
83SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15582460
84NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15323029
85* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14241400
86* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13557648
87EZH2_27294783_Chip-Seq_ESCs_Mouse1.12974600
88KDM2B_26808549_Chip-Seq_JURKAT_Human1.12712423
89* SA1_27219007_Chip-Seq_ERYTHROID_Human1.12086713
90* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10297367
91SALL4_18804426_ChIP-ChIP_XEN_Mouse1.09625317
92SMC3_22415368_ChIP-Seq_MEFs_Mouse1.08373328
93SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.08220647
94TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.07812539
95RING1B_27294783_Chip-Seq_NPCs_Mouse1.07355700
96DROSHA_22980978_ChIP-Seq_HELA_Human1.07326613
97P63_26484246_Chip-Seq_KERATINOCYTES_Human1.07158753
98FOXO3_23340844_ChIP-Seq_DLD1_Human1.06890155
99KDM2B_26808549_Chip-Seq_DND41_Human1.06824949
100WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06777747
101MTF2_20144788_ChIP-Seq_MESCs_Mouse1.06068205
102TBX20_22328084_ChIP-Seq_HEART_Mouse1.05824676
103TBX20_22080862_ChIP-Seq_HEART_Mouse1.05824676
104SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.05523629
105SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.05523629
106JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05197381
107NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05141789
108* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.04698226
109SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04581061
110VDR_21846776_ChIP-Seq_THP-1_Human1.04187209
111FOXA2_19822575_ChIP-Seq_HepG2_Human1.04114987
112HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03519900
113EED_16625203_ChIP-ChIP_MESCs_Mouse1.03291605
114CTCF_27219007_Chip-Seq_Bcells_Human1.03242801
115TET1_21490601_ChIP-Seq_MESCs_Mouse1.03136361
116NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02930265
117TCF3_18692474_ChIP-Seq_MESCs_Mouse1.01725161
118SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.01703064
119KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99848352
120ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99806993
121* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.99667832
122SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.99646053
123NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.99473386
124* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99219475
125ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98467599
126SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.98145622
127* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97868342
128DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97283504
129ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97020290
130CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95031203
131RING1B_27294783_Chip-Seq_ESCs_Mouse0.94429157
132PPAR_26484153_Chip-Seq_NCI-H1993_Human0.94156448
133MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.93908339
134ESR1_20079471_ChIP-ChIP_T-47D_Human0.93724355
135STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.93655775
136CDX2_20551321_ChIP-Seq_CACO-2_Human0.93380564
137POU5F1_16518401_ChIP-PET_MESCs_Mouse0.93291246

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ3.24595864
2MP0003705_abnormal_hypodermis_morpholog3.17889626
3MP0004272_abnormal_basement_membrane2.77610094
4MP0005623_abnormal_meninges_morphology2.76218372
5MP0008438_abnormal_cutaneous_collagen2.48931479
6MP0000537_abnormal_urethra_morphology2.45463812
7MP0010030_abnormal_orbit_morphology2.35104347
8MP0005409_darkened_coat_color2.23661716
9MP0009053_abnormal_anal_canal1.89395513
10MP0009780_abnormal_chondrocyte_physiolo1.86580554
11MP0005360_urolithiasis1.80149426
12MP0000013_abnormal_adipose_tissue1.80022642
13MP0003941_abnormal_skin_development1.77593110
14MP0010368_abnormal_lymphatic_system1.76718155
15MP0000566_synostosis1.75908017
16MP0003119_abnormal_digestive_system1.73690548
17MP0000462_abnormal_digestive_system1.72962364
18MP0002653_abnormal_ependyma_morphology1.70895798
19MP0003385_abnormal_body_wall1.66339762
20MP0010234_abnormal_vibrissa_follicle1.62963704
21MP0003122_maternal_imprinting1.61606031
22MP0000534_abnormal_ureter_morphology1.61248792
23MP0003566_abnormal_cell_adhesion1.60381307
24MP0002249_abnormal_larynx_morphology1.57490624
25MP0000767_abnormal_smooth_muscle1.56904251
26MP0002060_abnormal_skin_morphology1.53827073
27MP0004233_abnormal_muscle_weight1.53684091
28MP0002877_abnormal_melanocyte_morpholog1.50659633
29MP0000579_abnormal_nail_morphology1.48672918
30MP0002234_abnormal_pharynx_morphology1.45981332
31MP0002139_abnormal_hepatobiliary_system1.45694800
32MP0000003_abnormal_adipose_tissue1.44888340
33MP0002796_impaired_skin_barrier1.40410752
34MP0002896_abnormal_bone_mineralization1.40314818
35MP0005275_abnormal_skin_tensile1.38032140
36MP0009384_cardiac_valve_regurgitation1.37625759
37MP0003942_abnormal_urinary_system1.35317307
38MP0001299_abnormal_eye_distance/1.33944839
39MP0000678_abnormal_parathyroid_gland1.30083767
40MP0003453_abnormal_keratinocyte_physiol1.29991731
41MP0004133_heterotaxia1.29435016
42MP0003115_abnormal_respiratory_system1.25495175
43MP0005503_abnormal_tendon_morphology1.24817348
44MP0001879_abnormal_lymphatic_vessel1.24600558
45MP0003252_abnormal_bile_duct1.24067411
46MP0005501_abnormal_skin_physiology1.22208886
47MP0004270_analgesia1.21389752
48MP0000733_abnormal_muscle_development1.19060542
49MP0004858_abnormal_nervous_system1.18637594
50MP0010352_gastrointestinal_tract_polyps1.18345867
51MP0003091_abnormal_cell_migration1.16694996
52MP0005257_abnormal_intraocular_pressure1.16368906
53MP0005451_abnormal_body_composition1.15638792
54MP0003123_paternal_imprinting1.15248649
55MP0003279_aneurysm1.14727624
56MP0001849_ear_inflammation1.12428760
57MP0004043_abnormal_pH_regulation1.10459521
58MP0002697_abnormal_eye_size1.09422275
59MP0003806_abnormal_nucleotide_metabolis1.08235060
60MP0005248_abnormal_Harderian_gland1.05722797
61MP0004084_abnormal_cardiac_muscle1.05626303
62MP0004885_abnormal_endolymph1.05472646
63MP0005670_abnormal_white_adipose1.04687273
64MP0006138_congestive_heart_failure1.04447740
65MP0003755_abnormal_palate_morphology1.04165256
66MP0003329_amyloid_beta_deposits1.03421172
67MP0003937_abnormal_limbs/digits/tail_de1.01879344
68MP0004145_abnormal_muscle_electrophysio1.01616407
69MP0005187_abnormal_penis_morphology0.99825103
70MP0009840_abnormal_foam_cell0.99180906
71MP0000759_abnormal_skeletal_muscle0.97890800
72MP0005058_abnormal_lysosome_morphology0.97872866
73MP0000428_abnormal_craniofacial_morphol0.97342921
74MP0003950_abnormal_plasma_membrane0.96958874
75MP0002932_abnormal_joint_morphology0.94555138
76MP0009672_abnormal_birth_weight0.93570953
77MP0002269_muscular_atrophy0.92875206
78MP0004859_abnormal_synaptic_plasticity0.92268009
79MP0000467_abnormal_esophagus_morphology0.92238984
80MP0003935_abnormal_craniofacial_develop0.92204264
81MP0005508_abnormal_skeleton_morphology0.92079956
82MP0005375_adipose_tissue_phenotype0.91306179
83MP0005085_abnormal_gallbladder_physiolo0.91092059
84MP0009250_abnormal_appendicular_skeleto0.90781489
85MP0002084_abnormal_developmental_patter0.90775463
86MP0001348_abnormal_lacrimal_gland0.90190595
87MP0002111_abnormal_tail_morphology0.89467766
88MP0000049_abnormal_middle_ear0.89369257
89MP0005076_abnormal_cell_differentiation0.89330249
90MP0005083_abnormal_biliary_tract0.89186372
91MP0002089_abnormal_postnatal_growth/wei0.87871986
92MP0004197_abnormal_fetal_growth/weight/0.87577566
93MP0000747_muscle_weakness0.87549553
94MP0002295_abnormal_pulmonary_circulatio0.86651674
95MP0000762_abnormal_tongue_morphology0.86622592
96MP0005023_abnormal_wound_healing0.85226760
97MP0000751_myopathy0.84940187
98MP0000749_muscle_degeneration0.84801735
99MP0003195_calcinosis0.84256100
100MP0004185_abnormal_adipocyte_glucose0.83573905
101MP0004264_abnormal_extraembryonic_tissu0.83463730
102MP0000750_abnormal_muscle_regeneration0.82949096
103MP0001944_abnormal_pancreas_morphology0.82704908
104* MP0005595_abnormal_vascular_smooth0.82565502
105MP0005220_abnormal_exocrine_pancreas0.82540820
106MP0002254_reproductive_system_inflammat0.81833170
107MP0001666_abnormal_nutrient_absorption0.81445956
108MP0002233_abnormal_nose_morphology0.81412309
109MP0001915_intracranial_hemorrhage0.81226945
110MP0001958_emphysema0.81134623
111* MP0002925_abnormal_cardiovascular_devel0.79785745
112MP0002085_abnormal_embryonic_tissue0.79184978
113* MP0001614_abnormal_blood_vessel0.78150827
114MP0000432_abnormal_head_morphology0.77826295
115MP0006054_spinal_hemorrhage0.77630485
116MP0003861_abnormal_nervous_system0.76810732
117MP0005197_abnormal_uvea_morphology0.76670037
118* MP0010630_abnormal_cardiac_muscle0.76567328
119MP0005365_abnormal_bile_salt0.75923583
120MP0002116_abnormal_craniofacial_bone0.75872373
121* MP0004087_abnormal_muscle_fiber0.75557814
122MP0002909_abnormal_adrenal_gland0.75476909
123MP0002108_abnormal_muscle_morphology0.75295933
124MP0000163_abnormal_cartilage_morphology0.74623343
125MP0001243_abnormal_dermal_layer0.74511854
126MP0005330_cardiomyopathy0.74435989
127MP0001542_abnormal_bone_strength0.74075684
128MP0001730_embryonic_growth_arrest0.73474266
129MP0005666_abnormal_adipose_tissue0.72574536
130MP0008961_abnormal_basal_metabolism0.72387555
131MP0010771_integument_phenotype0.72228209
132MP0005167_abnormal_blood-brain_barrier0.70499207
133MP0009703_decreased_birth_body0.70073857
134MP0002092_abnormal_eye_morphology0.70047685
135MP0002114_abnormal_axial_skeleton0.69591401
136MP0003634_abnormal_glial_cell0.68678567
137MP0000538_abnormal_urinary_bladder0.68308076
138MP0002098_abnormal_vibrissa_morphology0.67142247

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.12496090
2Premature rupture of membranes (HP:0001788)3.98919926
3Shallow orbits (HP:0000586)3.79437882
4Hyperacusis (HP:0010780)3.27833679
5Distal upper limb amyotrophy (HP:0007149)3.07350072
6Upper limb amyotrophy (HP:0009129)3.07350072
7Distal lower limb amyotrophy (HP:0008944)3.03370511
8Vascular tortuosity (HP:0004948)2.84510088
9Arterial tortuosity (HP:0005116)2.84013661
10Broad face (HP:0000283)2.76279683
11Hand muscle atrophy (HP:0009130)2.56508648
12Distal lower limb muscle weakness (HP:0009053)2.52839348
13Type 1 muscle fiber predominance (HP:0003803)2.49992727
14Turricephaly (HP:0000262)2.49885130
15Lower limb amyotrophy (HP:0007210)2.47692437
16Abnormality of dentin (HP:0010299)2.47425696
17Cerebral aneurysm (HP:0004944)2.46917533
18Aortic aneurysm (HP:0004942)2.42872086
19Obstructive sleep apnea (HP:0002870)2.39371803
20Bronchomalacia (HP:0002780)2.38522072
21Bladder diverticulum (HP:0000015)2.38385918
22Broad metatarsal (HP:0001783)2.37869163
23Mitral regurgitation (HP:0001653)2.37757238
24Vertebral compression fractures (HP:0002953)2.35060570
25Disproportionate tall stature (HP:0001519)2.34625021
26Coronal craniosynostosis (HP:0004440)2.33233161
27Atrophic scars (HP:0001075)2.31837398
28Back pain (HP:0003418)2.31462581
29Lymphangioma (HP:0100764)2.30043367
30Focal segmental glomerulosclerosis (HP:0000097)2.29029133
31Deep venous thrombosis (HP:0002625)2.22950296
32Difficulty climbing stairs (HP:0003551)2.22050702
33Biconcave vertebral bodies (HP:0004586)2.17749752
34Right ventricular cardiomyopathy (HP:0011663)2.14578846
35Hyporeflexia of lower limbs (HP:0002600)2.12282971
36Hypoglycemic seizures (HP:0002173)2.11306630
37Hyperinsulinemic hypoglycemia (HP:0000825)2.08245045
38Muscle fiber splitting (HP:0003555)2.06666602
39Fragile skin (HP:0001030)2.05674032
40Ankle contracture (HP:0006466)2.04307628
41Scapular winging (HP:0003691)2.01638818
42Spinal rigidity (HP:0003306)2.01356214
43Thin bony cortex (HP:0002753)2.00326379
44Hyperextensible skin (HP:0000974)2.00206689
45Bowing of the arm (HP:0006488)1.98347970
46Bowed forearm bones (HP:0003956)1.98347970
47Buphthalmos (HP:0000557)1.97826253
48Joint laxity (HP:0001388)1.96529037
49Increased connective tissue (HP:0009025)1.95593433
50Elbow flexion contracture (HP:0002987)1.94647113
51Natal tooth (HP:0000695)1.94186371
52Glomerulosclerosis (HP:0000096)1.92393767
53Abnormality of the lower motor neuron (HP:0002366)1.91826081
54Aneurysm (HP:0002617)1.91108895
55Cerebral inclusion bodies (HP:0100314)1.88567901
56Generalized amyotrophy (HP:0003700)1.88449152
57Advanced eruption of teeth (HP:0006288)1.88297909
58Congenital glaucoma (HP:0001087)1.86729422
59Trismus (HP:0000211)1.85732810
60Blue sclerae (HP:0000592)1.85323889
61Flat acetabular roof (HP:0003180)1.85081700
62Overgrowth (HP:0001548)1.84036588
63Genu recurvatum (HP:0002816)1.83906192
64Hepatoblastoma (HP:0002884)1.82994774
65Intrahepatic cholestasis (HP:0001406)1.82464782
66Abnormality of skeletal muscle fiber size (HP:0012084)1.82360377
67Neonatal short-limb short stature (HP:0008921)1.82334040
68Mildly elevated creatine phosphokinase (HP:0008180)1.82098839
69Aplasia involving bones of the extremities (HP:0009825)1.81607994
70Aplasia involving bones of the upper limbs (HP:0009823)1.81607994
71Aplasia of the phalanges of the hand (HP:0009802)1.81607994
72Hypoventilation (HP:0002791)1.81412148
73Arnold-Chiari malformation (HP:0002308)1.80474267
74Wormian bones (HP:0002645)1.80235357
75Thin ribs (HP:0000883)1.79803232
76Increased variability in muscle fiber diameter (HP:0003557)1.79709102
77Vertebral clefting (HP:0008428)1.77095622
78Renal duplication (HP:0000075)1.75554603
79Xanthomatosis (HP:0000991)1.74663059
80Long toe (HP:0010511)1.73952661
81Abnormality of the acetabulum (HP:0003170)1.73793152
82Vertebral arch anomaly (HP:0008438)1.73180169
83Asymmetry of the thorax (HP:0001555)1.72760311
84Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.72130771
85Selective tooth agenesis (HP:0001592)1.72100551
86Neoplasm of the heart (HP:0100544)1.72003036
87Ectopia lentis (HP:0001083)1.71708998
88Coxa vara (HP:0002812)1.71054447
89Wrist flexion contracture (HP:0001239)1.70370960
90Overriding aorta (HP:0002623)1.70030323
91Abnormal ossification of hand bones (HP:0005921)1.69799077
92Bowel diverticulosis (HP:0005222)1.69686583
93Premature skin wrinkling (HP:0100678)1.69673159
94Mitral valve prolapse (HP:0001634)1.69045777
95Peritonitis (HP:0002586)1.68962745
96Hemorrhage of the eye (HP:0011885)1.68077225
97Hypoglycemic coma (HP:0001325)1.67769925
98Abnormality of monocarboxylic acid metabolism (HP:0010996)1.66416296
99Abnormality of the Achilles tendon (HP:0005109)1.66367434
100Fused cervical vertebrae (HP:0002949)1.66114709
101Elfin facies (HP:0004428)1.65566783
102Aortic regurgitation (HP:0001659)1.65549569
103Symptomatic seizures (HP:0011145)1.65330482
104Abnormality of carpal bone ossification (HP:0006257)1.64690806
105Slender build (HP:0001533)1.63004157
106Spinal cord compression (HP:0002176)1.62873669
107Achilles tendon contracture (HP:0001771)1.62657178
108Skin nodule (HP:0200036)1.62458853
109Late onset (HP:0003584)1.61033317
110Soft skin (HP:0000977)1.60855454
111Aortic dissection (HP:0002647)1.60050821
112Osteolytic defects of the hand bones (HP:0009699)1.59535709
113Osteolytic defects of the phalanges of the hand (HP:0009771)1.59535709
114Nuclear cataract (HP:0100018)1.59131318
115Cervical subluxation (HP:0003308)1.59127062
116Hyperglycemia (HP:0003074)1.58555332
117Pseudobulbar signs (HP:0002200)1.58169425
118Abnormal vertebral ossification (HP:0100569)1.57269366
119Neurofibrillary tangles (HP:0002185)1.56159539
120Abnormality of the distal phalanx of the thumb (HP:0009617)1.55291274
121Wide anterior fontanel (HP:0000260)1.54187084
122Abnormal pancreas size (HP:0012094)1.52489762
123Pterygium (HP:0001059)1.50893672
124Stridor (HP:0010307)1.50355325
125Difficulty running (HP:0009046)1.50272871
126Tibial bowing (HP:0002982)1.50009886
127Deviation of the hallux (HP:0010051)1.49897221
128Ketoacidosis (HP:0001993)1.49759940
129Short nail (HP:0001799)1.47809752
130Short hallux (HP:0010109)1.47492271
131Abnormality of aromatic amino acid family metabolism (HP:0004338)1.46508296
132Short humerus (HP:0005792)1.46233357
133Ulnar bowing (HP:0003031)1.45769482
134Insomnia (HP:0100785)1.45503284
135Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.44071884
136Vertebral hypoplasia (HP:0008417)1.44071884
137Round ear (HP:0100830)1.43236617
138Shawl scrotum (HP:0000049)1.43197955
139Abnormality of the calcaneus (HP:0008364)1.42674270
140Dilatation of the ascending aorta (HP:0005111)1.42278186
141Ileus (HP:0002595)1.42078458
142Abnormality of the pancreatic islet cells (HP:0006476)1.41907760
143Abnormality of endocrine pancreas physiology (HP:0012093)1.41907760
144Hallux valgus (HP:0001822)1.41427684
145Long palpebral fissure (HP:0000637)1.40028846
146Hyperparathyroidism (HP:0000843)1.38901972
147Missing ribs (HP:0000921)1.38826449
148Abnormality of the aortic arch (HP:0012303)1.38514006

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA23.10269179
2TRIB33.09280829
3MST1R3.04643795
4LATS22.52351823
5ICK2.51094029
6PRKD32.50087224
7SMG12.37540343
8LATS12.31438783
9EPHB22.28815937
10IRAK32.25115441
11PDGFRA2.24695657
12MET2.21292595
13RIPK12.13352955
14DDR22.05846701
15TTN1.95106722
16* PTK21.91697191
17PKN21.91011472
18TYRO31.84838092
19LMTK21.83725432
20WNK41.76584642
21LIMK11.75864014
22PAK31.75130081
23FGFR41.50617305
24TESK11.48967277
25FER1.48780539
26ERN11.47698315
27BMX1.47120159
28PAK61.43615816
29NTRK11.43245682
30MYLK1.40497564
31SIK11.36766213
32MAP3K101.32694121
33CDK121.27630360
34MTOR1.26743461
35STK391.26336183
36MAP3K91.23081967
37PAK21.22585522
38KSR21.16429178
39ARAF1.14671445
40MAP2K21.14054804
41PASK1.11957770
42STK38L1.11014283
43RPS6KA21.09083265
44PAK41.04598944
45KDR1.03700234
46MAP3K21.03419984
47TESK21.02543686
48ERBB41.02235069
49WNK11.01408595
50EPHB10.98848714
51CDC42BPA0.97175382
52* PTK60.92645595
53UHMK10.92389749
54MAPK150.91915477
55MAP2K10.90704192
56BCR0.89226834
57TIE10.88729108
58ROCK10.82366040
59DMPK0.82201087
60OXSR10.81654542
61ROCK20.80828415
62FGFR20.80762480
63WNK30.79490183
64PTK2B0.76091196
65PDGFRB0.76026936
66CDK140.75146053
67RET0.75047120
68PIM20.74961232
69TAOK20.74245984
70ILK0.72005353
71NEK10.70783597
72CDK150.70441055
73MAP3K60.69576779
74MOS0.67614344
75ERBB20.67521767
76BRAF0.67493986
77NME20.67313558
78MARK20.66281210
79DYRK1B0.64440373
80CDK180.64309884
81PRKD10.64003316
82SCYL20.63507672
83ALK0.62989197
84MAP3K110.62125302
85MAP3K30.61440668
86CAMK2G0.61374993
87CDK11A0.61159628
88PDPK10.59621866
89INSRR0.59467022
90PRKD20.59442295
91CSNK1A1L0.59163795
92CAMK1G0.58487139
93MAPKAPK30.57129748
94PAK10.55184076
95KSR10.55166768
96DAPK30.55089748
97MINK10.54533338
98TGFBR20.53391865
99CAMKK10.53353397
100PRKCI0.53248164
101RPS6KC10.52371958
102RPS6KL10.52371958
103STK380.52029810
104ABL20.51924436
105MARK10.50570708
106MAP3K80.50276041
107CSNK1E0.49384434
108CDK80.47742906
109MAP3K70.47629129
110STK110.46454707
111RPS6KB20.46239940
112LRRK20.45504018
113TAOK10.45236799
114GSK3A0.44370614
115IRAK20.44189742
116CAMK2D0.43381756
117PHKG10.42914094
118PHKG20.42914094
119* FGFR10.42854689
120PRKG20.42413331
121PNCK0.41641000
122PRPF4B0.41334132
123DYRK20.40210473
124CAMK1D0.39706016
125AKT20.39330639
126EEF2K0.38927007
127PRKCH0.38557168
128CAMK2B0.38231260
129FLT30.37174161
130MAP3K10.36734626
131MUSK0.33696635
132RPS6KA60.33562178
133CDK70.33142020
134MAP2K30.32446025
135HIPK20.30493956
136MAP3K130.29535399

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049502.83000366
2Nitrogen metabolism_Homo sapiens_hsa009102.39635765
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.13354905
4Hippo signaling pathway_Homo sapiens_hsa043901.84631404
5Tight junction_Homo sapiens_hsa045301.79002407
6ECM-receptor interaction_Homo sapiens_hsa045121.71264965
7Hedgehog signaling pathway_Homo sapiens_hsa043401.68789247
8Bladder cancer_Homo sapiens_hsa052191.65629991
9Basal cell carcinoma_Homo sapiens_hsa052171.60607116
10Bile secretion_Homo sapiens_hsa049761.59864560
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.54803455
12Butanoate metabolism_Homo sapiens_hsa006501.49752484
13Cyanoamino acid metabolism_Homo sapiens_hsa004601.45703908
14Arginine biosynthesis_Homo sapiens_hsa002201.44111295
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.42016483
16Sulfur metabolism_Homo sapiens_hsa009201.41654781
17* Focal adhesion_Homo sapiens_hsa045101.41250730
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.38395470
19Adherens junction_Homo sapiens_hsa045201.36476197
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.31922832
21Fructose and mannose metabolism_Homo sapiens_hsa000511.31065632
22Axon guidance_Homo sapiens_hsa043601.30971196
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.29880995
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.27896929
25Proteoglycans in cancer_Homo sapiens_hsa052051.27554260
26Galactose metabolism_Homo sapiens_hsa000521.26100119
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25868155
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.25187225
29Sulfur relay system_Homo sapiens_hsa041221.25111910
30Fat digestion and absorption_Homo sapiens_hsa049751.21257121
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.20574789
32Tryptophan metabolism_Homo sapiens_hsa003801.19724243
33Dilated cardiomyopathy_Homo sapiens_hsa054141.19015700
34Protein digestion and absorption_Homo sapiens_hsa049741.18738678
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.17021383
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16236220
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.14638035
38Other glycan degradation_Homo sapiens_hsa005111.14128682
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.13525192
40Pentose phosphate pathway_Homo sapiens_hsa000301.13314937
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12833623
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.12411314
43Vitamin B6 metabolism_Homo sapiens_hsa007501.12121384
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11048179
45* Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11010223
46VEGF signaling pathway_Homo sapiens_hsa043701.09946994
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05385279
48Insulin secretion_Homo sapiens_hsa049111.05267356
49Insulin signaling pathway_Homo sapiens_hsa049101.05235326
50Primary bile acid biosynthesis_Homo sapiens_hsa001201.04201962
51Gap junction_Homo sapiens_hsa045401.03366279
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.02300282
53Fatty acid degradation_Homo sapiens_hsa000711.02231883
54Lysine degradation_Homo sapiens_hsa003101.02130080
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00057505
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99791951
57Selenocompound metabolism_Homo sapiens_hsa004500.99560468
58Fatty acid metabolism_Homo sapiens_hsa012120.99123679
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.98340326
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98153470
61Arginine and proline metabolism_Homo sapiens_hsa003300.96573105
62Steroid biosynthesis_Homo sapiens_hsa001000.93662787
63Melanogenesis_Homo sapiens_hsa049160.92570382
64Biosynthesis of amino acids_Homo sapiens_hsa012300.92219555
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.88671633
66Estrogen signaling pathway_Homo sapiens_hsa049150.88600832
67Renal cell carcinoma_Homo sapiens_hsa052110.88591317
68Amoebiasis_Homo sapiens_hsa051460.87903641
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.86884549
70TGF-beta signaling pathway_Homo sapiens_hsa043500.86030515
71PPAR signaling pathway_Homo sapiens_hsa033200.84219717
72Pyruvate metabolism_Homo sapiens_hsa006200.84006013
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.83960319
74Thyroid hormone synthesis_Homo sapiens_hsa049180.83909056
75Endometrial cancer_Homo sapiens_hsa052130.78530941
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.76737078
77Pathways in cancer_Homo sapiens_hsa052000.76254773
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75560766
79Type II diabetes mellitus_Homo sapiens_hsa049300.75192469
80Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74842735
81Cocaine addiction_Homo sapiens_hsa050300.74155243
82Carbon metabolism_Homo sapiens_hsa012000.73339299
83MicroRNAs in cancer_Homo sapiens_hsa052060.73261402
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72453063
85Vibrio cholerae infection_Homo sapiens_hsa051100.72136667
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69420544
87* Leukocyte transendothelial migration_Homo sapiens_hsa046700.68163626
88Endocytosis_Homo sapiens_hsa041440.67983764
89Wnt signaling pathway_Homo sapiens_hsa043100.67462713
90AMPK signaling pathway_Homo sapiens_hsa041520.67294004
91Glucagon signaling pathway_Homo sapiens_hsa049220.66984587
92Glioma_Homo sapiens_hsa052140.66974801
93Pancreatic cancer_Homo sapiens_hsa052120.66124547
94Prion diseases_Homo sapiens_hsa050200.65957572
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65066715
96Ovarian steroidogenesis_Homo sapiens_hsa049130.64680598
97Small cell lung cancer_Homo sapiens_hsa052220.63859552
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63146104
99ErbB signaling pathway_Homo sapiens_hsa040120.62171354
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62132041
101N-Glycan biosynthesis_Homo sapiens_hsa005100.62080710
102mTOR signaling pathway_Homo sapiens_hsa041500.62041824
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60205717
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59374324
105Melanoma_Homo sapiens_hsa052180.58903104
106Long-term potentiation_Homo sapiens_hsa047200.58755962
107Gastric acid secretion_Homo sapiens_hsa049710.58464844
108Inositol phosphate metabolism_Homo sapiens_hsa005620.57435261
109Phenylalanine metabolism_Homo sapiens_hsa003600.56035437
110Thyroid cancer_Homo sapiens_hsa052160.55976497
111Insulin resistance_Homo sapiens_hsa049310.55795705
112* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55733478
113Choline metabolism in cancer_Homo sapiens_hsa052310.55486820
114Non-small cell lung cancer_Homo sapiens_hsa052230.55385641
115GnRH signaling pathway_Homo sapiens_hsa049120.54346109
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.54233724
117Mineral absorption_Homo sapiens_hsa049780.54216450
118* Rap1 signaling pathway_Homo sapiens_hsa040150.53752518
119Histidine metabolism_Homo sapiens_hsa003400.52912228
120Synaptic vesicle cycle_Homo sapiens_hsa047210.52671025
121Dorso-ventral axis formation_Homo sapiens_hsa043200.52639459
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52170888
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51806063
124Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51700802
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50659745
126Notch signaling pathway_Homo sapiens_hsa043300.49267575
127Chronic myeloid leukemia_Homo sapiens_hsa052200.48631907
128Prostate cancer_Homo sapiens_hsa052150.47297970
129Tyrosine metabolism_Homo sapiens_hsa003500.47227481
130Vascular smooth muscle contraction_Homo sapiens_hsa042700.46939180
131Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46767691

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