BCAR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)7.46017479
2cell adhesion mediated by integrin (GO:0033627)5.67333894
3negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.31701066
4desmosome organization (GO:0002934)4.92469223
5urea cycle (GO:0000050)4.82207699
6urea metabolic process (GO:0019627)4.82207699
7mitotic metaphase plate congression (GO:0007080)4.82164707
8regulation of transcription from RNA polymerase I promoter (GO:0006356)4.81948336
9skin morphogenesis (GO:0043589)4.70970574
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.69281678
11cell-substrate junction assembly (GO:0007044)4.41482924
12nitrogen cycle metabolic process (GO:0071941)4.36670105
13regulation of bile acid biosynthetic process (GO:0070857)4.21357366
14serine family amino acid catabolic process (GO:0009071)4.17240815
15COPI coating of Golgi vesicle (GO:0048205)4.08057922
16Golgi transport vesicle coating (GO:0048200)4.08057922
17substrate-dependent cell migration (GO:0006929)4.04272475
18protein localization to endosome (GO:0036010)4.00652658
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.98629934
20L-phenylalanine catabolic process (GO:0006559)3.98629934
21cysteine metabolic process (GO:0006534)3.97003052
22aromatic amino acid family catabolic process (GO:0009074)3.96402310
23regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.94842978
24endodermal cell differentiation (GO:0035987)3.93248066
25regulation of retinoic acid receptor signaling pathway (GO:0048385)3.91861491
26mesodermal cell differentiation (GO:0048333)3.85785241
27indole-containing compound catabolic process (GO:0042436)3.84878721
28indolalkylamine catabolic process (GO:0046218)3.84878721
29tryptophan catabolic process (GO:0006569)3.84878721
30wound healing, spreading of epidermal cells (GO:0035313)3.81305364
31regulation of establishment of cell polarity (GO:2000114)3.78539444
32pentose-phosphate shunt (GO:0006098)3.72523528
33snRNA transcription (GO:0009301)3.71025109
34regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.69381770
35erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.68209965
36L-phenylalanine metabolic process (GO:0006558)3.68209965
37kynurenine metabolic process (GO:0070189)3.65832914
38acylglycerol homeostasis (GO:0055090)3.65343671
39triglyceride homeostasis (GO:0070328)3.65343671
40tryptophan metabolic process (GO:0006568)3.63930388
41regulation of sister chromatid cohesion (GO:0007063)3.61719869
42epithelial cell-cell adhesion (GO:0090136)3.60059066
43negative regulation of chondrocyte differentiation (GO:0032331)3.60001878
44retina vasculature morphogenesis in camera-type eye (GO:0061299)3.57885427
45sulfur amino acid catabolic process (GO:0000098)3.57458594
46high-density lipoprotein particle remodeling (GO:0034375)3.57136818
47dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.56348481
48bile acid and bile salt transport (GO:0015721)3.56314808
49urate metabolic process (GO:0046415)3.55542468
50membrane raft organization (GO:0031579)3.54262371
51complement activation, alternative pathway (GO:0006957)3.54137424
52regulation of transforming growth factor beta2 production (GO:0032909)3.50663488
53mitotic chromosome condensation (GO:0007076)3.50449886
54bile acid biosynthetic process (GO:0006699)3.49709671
55regulation of protein activation cascade (GO:2000257)3.49665147
56metaphase plate congression (GO:0051310)3.48014433
57pentose metabolic process (GO:0019321)3.47429703
58regulation of spindle organization (GO:0090224)3.45653705
59NADPH regeneration (GO:0006740)3.43663313
60wound healing, spreading of cells (GO:0044319)3.42878580
61homocysteine metabolic process (GO:0050667)3.41386031
62regulation of establishment or maintenance of cell polarity (GO:0032878)3.36440970
63negative regulation of fibrinolysis (GO:0051918)3.36184756
64fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.35660980
65drug catabolic process (GO:0042737)3.35318058
66regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.35171564
67regulation of triglyceride catabolic process (GO:0010896)3.32229411
68bile acid metabolic process (GO:0008206)3.32018015
69regulation of complement activation (GO:0030449)3.31757723
70alpha-linolenic acid metabolic process (GO:0036109)3.30865047
71complement activation, classical pathway (GO:0006958)3.30701406
72negative regulation of fatty acid biosynthetic process (GO:0045717)3.30062372
73glucose catabolic process (GO:0006007)3.29998181
74reverse cholesterol transport (GO:0043691)3.29509448
75DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.27566954
76protein localization to chromosome, centromeric region (GO:0071459)3.26735514
77regulation of exit from mitosis (GO:0007096)3.25144224
78plasma lipoprotein particle clearance (GO:0034381)3.24737660
79positive regulation of osteoblast proliferation (GO:0033690)3.24591390
80cellular response to vitamin D (GO:0071305)3.21598920
81glycine metabolic process (GO:0006544)3.20694641
82monoubiquitinated protein deubiquitination (GO:0035520)3.19479711
83amino-acid betaine metabolic process (GO:0006577)3.17675581
84cellular response to vitamin (GO:0071295)3.16722660
85peptidyl-glutamic acid carboxylation (GO:0017187)3.16565820
86protein carboxylation (GO:0018214)3.16565820
87cell migration involved in sprouting angiogenesis (GO:0002042)3.16024849
88atrioventricular valve morphogenesis (GO:0003181)3.15952719
89regulation of cholesterol homeostasis (GO:2000188)3.15608229
90protein-lipid complex remodeling (GO:0034368)3.13802004
91macromolecular complex remodeling (GO:0034367)3.13802004
92plasma lipoprotein particle remodeling (GO:0034369)3.13802004
93protein localization to kinetochore (GO:0034501)3.12302958
94DNA damage response, signal transduction resulting in transcription (GO:0042772)3.11720256
95negative regulation of keratinocyte proliferation (GO:0010839)3.11512357
96positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.11015669
97positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.11015669
98positive regulation of mitotic sister chromatid separation (GO:1901970)3.11015669
99fat-soluble vitamin biosynthetic process (GO:0042362)3.10927622
100notochord development (GO:0030903)3.10166727
101chondrocyte proliferation (GO:0035988)3.08481621
102regulation of fibrinolysis (GO:0051917)3.06728006
103phospholipid efflux (GO:0033700)3.06007514
104glomerular visceral epithelial cell development (GO:0072015)3.05072919
105actin filament depolymerization (GO:0030042)3.04821784
106endothelial cell chemotaxis (GO:0035767)3.04472406
107complement activation (GO:0006956)3.04414674
108hippo signaling (GO:0035329)3.02598462
109maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.00879234
110regulation of cholesterol esterification (GO:0010872)2.99704866
111endothelial cell morphogenesis (GO:0001886)2.99386830
112negative regulation of sterol transport (GO:0032372)2.99151564
113negative regulation of cholesterol transport (GO:0032375)2.99151564
114regulation of meiosis I (GO:0060631)2.98950499
115negative regulation of anoikis (GO:2000811)2.98364359
116cell-substrate adherens junction assembly (GO:0007045)2.94590955
117focal adhesion assembly (GO:0048041)2.94590955
118positive regulation of chromosome segregation (GO:0051984)2.93970509
119serine family amino acid metabolic process (GO:0009069)2.93916211
120protein-lipid complex assembly (GO:0065005)2.93813993
121protein hydroxylation (GO:0018126)2.92451110
122oocyte maturation (GO:0001556)2.91948047
123protein K6-linked ubiquitination (GO:0085020)2.91438211
124adherens junction assembly (GO:0034333)2.90630736
125regulation of RNA export from nucleus (GO:0046831)2.88515153
126hypotonic response (GO:0006971)2.88320015
127regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.88233297
128glyoxylate metabolic process (GO:0046487)2.88023404
129activation of Rac GTPase activity (GO:0032863)2.87911127
130muscle cell migration (GO:0014812)2.87559656
131maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.87512623
132negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.87509435
133negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.87013465
134meiosis I (GO:0007127)2.86639898
135low-density lipoprotein particle clearance (GO:0034383)2.86408660
136cholesterol efflux (GO:0033344)2.86081142
137fatty acid homeostasis (GO:0055089)2.85296204
138establishment of chromosome localization (GO:0051303)2.84086763
139arginine metabolic process (GO:0006525)2.83800615
140aromatic amino acid family metabolic process (GO:0009072)2.83556801
141protein retention in ER lumen (GO:0006621)2.82860072
142bundle of His cell to Purkinje myocyte communication (GO:0086069)2.82514494
143type B pancreatic cell proliferation (GO:0044342)2.82075816
144virion attachment to host cell (GO:0019062)2.81591975
145adhesion of symbiont to host cell (GO:0044650)2.81591975
146response to hydroperoxide (GO:0033194)2.80155405
147positive regulation of lipid catabolic process (GO:0050996)2.80112094
148regulation of hippo signaling (GO:0035330)2.79708803
149sterol homeostasis (GO:0055092)2.79682265
150heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.75735077
151basement membrane organization (GO:0071711)2.75729854
152regulation of anoikis (GO:2000209)2.75150429
153kidney mesenchyme development (GO:0072074)2.72708821
154keratinocyte proliferation (GO:0043616)2.72702910
155regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.72396556
156collagen fibril organization (GO:0030199)2.72316146
157UDP-N-acetylglucosamine metabolic process (GO:0006047)2.72307802
158plasma membrane repair (GO:0001778)2.71925286
159regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.71176044
160peptidyl-proline hydroxylation (GO:0019511)2.70630360
161glomerular basement membrane development (GO:0032836)2.70279745
162regulation of apoptotic process involved in morphogenesis (GO:1902337)2.65329375
163regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.63457956
164regulation of gonadotropin secretion (GO:0032276)2.63269538
165glomerular epithelial cell development (GO:0072310)2.62243861
166vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.61736889
167negative regulation of cartilage development (GO:0061037)2.60504312
168positive regulation of blood vessel endothelial cell migration (GO:0043536)2.60248484
169regulation of transforming growth factor beta1 production (GO:0032908)2.60075350
170adhesion of symbiont to host (GO:0044406)2.59944777
171barbed-end actin filament capping (GO:0051016)2.59363031
172protein maturation by protein folding (GO:0022417)2.58488178
173neuron projection extension involved in neuron projection guidance (GO:1902284)2.58428567
174axon extension involved in axon guidance (GO:0048846)2.58428567
175branching involved in mammary gland duct morphogenesis (GO:0060444)2.57442687
176cytoskeletal anchoring at plasma membrane (GO:0007016)2.57189354
177mammary gland epithelial cell proliferation (GO:0033598)2.56099741
178negative regulation of axon extension involved in axon guidance (GO:0048843)2.55460345
179nuclear envelope reassembly (GO:0031468)2.54864857
180mitotic nuclear envelope reassembly (GO:0007084)2.54864857
181sequestering of extracellular ligand from receptor (GO:0035581)2.53850628
182branching involved in salivary gland morphogenesis (GO:0060445)2.53263190
183endocardial cushion development (GO:0003197)2.52561793
184planar cell polarity pathway involved in neural tube closure (GO:0090179)2.50707470
185membrane protein ectodomain proteolysis (GO:0006509)2.50415460
186blood vessel endothelial cell migration (GO:0043534)2.49761189
187substrate adhesion-dependent cell spreading (GO:0034446)2.49304641
188stress fiber assembly (GO:0043149)2.47789355
189vascular endothelial growth factor signaling pathway (GO:0038084)2.47119399
190protein heterotrimerization (GO:0070208)2.47062731
191collagen metabolic process (GO:0032963)2.46688333
192positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.46624808
193COPII vesicle coating (GO:0048208)2.43457387
194negative regulation of stem cell proliferation (GO:2000647)2.42598811
195cell junction assembly (GO:0034329)2.42054976
196gap junction assembly (GO:0016264)2.40164942
197semaphorin-plexin signaling pathway (GO:0071526)2.40107995
198positive regulation of cartilage development (GO:0061036)2.40074861

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.01840923
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.73558102
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.03021414
4* RXR_22158963_ChIP-Seq_LIVER_Mouse4.89463115
5FOXM1_23109430_ChIP-Seq_U2OS_Human4.54719454
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.38605430
7* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.15691096
8* LXR_22158963_ChIP-Seq_LIVER_Mouse4.08677222
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human4.01376351
10RARG_19884340_ChIP-ChIP_MEFs_Mouse3.73868410
11TRIM28_21343339_ChIP-Seq_HEK293_Human3.73349667
12KAP1_22055183_ChIP-Seq_ESCs_Mouse3.67153297
13* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.97528230
14* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.97528230
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.83524732
16E2F7_22180533_ChIP-Seq_HELA_Human2.83136739
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.76119379
18NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.64180602
19HIF1A_21447827_ChIP-Seq_MCF-7_Human2.64041910
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.58319031
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.58100616
22AR_21909140_ChIP-Seq_LNCAP_Human2.51123620
23CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.50884468
24FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.44632981
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.36490859
26* CJUN_26792858_Chip-Seq_BT549_Human2.33635283
27TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.31265902
28RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.27934265
29* BRD4_25478319_ChIP-Seq_HGPS_Human2.27303501
30ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.18364844
31ELK3_25401928_ChIP-Seq_HUVEC_Human2.07813818
32ESR1_21235772_ChIP-Seq_MCF-7_Human2.05115991
33SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.05032158
34* UBF1/2_26484160_Chip-Seq_HMECs_Human2.03575198
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.96257225
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.95849691
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.95336658
38* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.94290880
39* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.93325186
40* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.88792132
41JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.85250113
42PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.83179808
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.78838593
44* GATA2_21666600_ChIP-Seq_HMVEC_Human1.78153324
45TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.77236408
46* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.74132709
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.71121841
48* RACK7_27058665_Chip-Seq_MCF-7_Human1.66608025
49Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.63153267
50* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.62244535
51* SOX2_20726797_ChIP-Seq_SW620_Human1.57775222
52EP300_21415370_ChIP-Seq_HL-1_Mouse1.57504925
53* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.56209467
54* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.56120218
55TP53_22127205_ChIP-Seq_IMR90_Human1.54988630
56UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.53496007
57P63_26484246_Chip-Seq_KERATINOCYTES_Human1.53383452
58TP53_18474530_ChIP-ChIP_U2OS_Human1.49659546
59TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49380148
60TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.49228672
61TP63_19390658_ChIP-ChIP_HaCaT_Human1.49170654
62IRF8_21731497_ChIP-ChIP_J774_Mouse1.45980973
63* FOXO3_23340844_ChIP-Seq_DLD1_Human1.41439351
64CLOCK_20551151_ChIP-Seq_293T_Human1.41380095
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.39715674
66* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.35063004
67HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.33461765
68NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.32355331
69STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29714813
70CDX2_20551321_ChIP-Seq_CACO-2_Human1.29193087
71* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.27897535
72* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.25317771
73* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25048951
74TBX20_22328084_ChIP-Seq_HEART_Mouse1.24072888
75TBX20_22080862_ChIP-Seq_HEART_Mouse1.24072888
76WT1_19549856_ChIP-ChIP_CCG9911_Human1.22873637
77STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20624714
78CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18961469
79* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18737466
80KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.17002772
81ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16700501
82IRF8_22096565_ChIP-ChIP_GC-B_Human1.16542954
83ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16432674
84SALL4_18804426_ChIP-ChIP_XEN_Mouse1.15919617
85ATF3_27146783_Chip-Seq_COLON_Human1.15587938
86SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14462212
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13534478
88PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.13091195
89CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12858219
90RUNX1_26923725_Chip-Seq_HPCs_Mouse1.12242702
91KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10880499
92FLI1_27457419_Chip-Seq_LIVER_Mouse1.10381701
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.09518033
94KAP1_27257070_Chip-Seq_ESCs_Mouse1.08995253
95ESR1_20079471_ChIP-ChIP_T-47D_Human1.08584075
96AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08556029
97ZNF263_19887448_ChIP-Seq_K562_Human1.08107196
98TP53_16413492_ChIP-PET_HCT116_Human1.06763665
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.05972296
100TP63_23658742_ChIP-Seq_EP156T_Human1.04965618
101* FOXA2_19822575_ChIP-Seq_HepG2_Human1.04841316
102* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.04365554
103SOX2_27498859_Chip-Seq_STOMACH_Mouse1.03209032
104MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.02678996
105* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01960547
106* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01960547
107ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.01781171
108* HNF4A_19822575_ChIP-Seq_HepG2_Human1.01079421
109* GATA4_25053715_ChIP-Seq_YYC3_Human1.00935910
110GATA3_24758297_ChIP-Seq_MCF-7_Human1.00230718
111E2F1_21310950_ChIP-Seq_MCF-7_Human1.00115392
112AHR_22903824_ChIP-Seq_MCF-7_Human0.99881518
113TP53_23651856_ChIP-Seq_MEFs_Mouse0.99702266
114* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.99401238
115FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99197871
116HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98616735
117NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97480528
118* NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97147072
119IRF8_27001747_Chip-Seq_BMDM_Mouse0.96215005
120GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95209463
121SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94304876
122SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.92609038
123* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.92390610
124ELK1_22589737_ChIP-Seq_MCF10A_Human0.92258955
125KLF5_25053715_ChIP-Seq_YYC3_Human0.91979811
126EGR1_19374776_ChIP-ChIP_THP-1_Human0.89100205
127STAT1_17558387_ChIP-Seq_HELA_Human0.88929053
128E2F4_17652178_ChIP-ChIP_JURKAT_Human0.88649597
129ESR2_21235772_ChIP-Seq_MCF-7_Human0.88529469
130CDX2_22108803_ChIP-Seq_LS180_Human0.88400203
131PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88201955
132MYB_21317192_ChIP-Seq_ERMYB_Mouse0.87891019
133TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86528131
134LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86200668
135NOTCH1_21737748_ChIP-Seq_TLL_Human0.85479825
136* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.85346343
137PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84199394
138* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83879565
139RXRA_24833708_ChIP-Seq_LIVER_Mouse0.83846825
140CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82239846
141SMC3_22415368_ChIP-Seq_MEFs_Mouse0.81233081
142FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.79829754
143FOXA1_25552417_ChIP-Seq_VCAP_Human0.79294930
144* GATA6_25053715_ChIP-Seq_YYC3_Human0.78055022
145NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.75577319
146CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73951662
147* SPI1_26923725_Chip-Seq_HPCs_Mouse0.73711629
148* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.73656689
149PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.73212355
150* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.72989152
151* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.72635339
152MYC_22102868_ChIP-Seq_BL_Human0.72625017
153FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.71746067
154NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.70943630
155* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.70227317
156MYC_18940864_ChIP-ChIP_HL60_Human0.70077461
157KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.69708832
158MYCN_18555785_ChIP-Seq_MESCs_Mouse0.69430772
159E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.69388797
160TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.68391920
161* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.65967359
162ERG_20517297_ChIP-Seq_VCAP_Human0.65846023
163* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.65411010
164KDM5A_27292631_Chip-Seq_BREAST_Human0.64337051
165SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.63833892
166* HNFA_21074721_ChIP-Seq_CACO-2_Human0.63720232

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.78417266
2MP0005360_urolithiasis5.71829908
3MP0005365_abnormal_bile_salt4.41485972
4MP0008438_abnormal_cutaneous_collagen4.25764813
5MP0005085_abnormal_gallbladder_physiolo3.87659045
6MP0004272_abnormal_basement_membrane3.71008536
7MP0003950_abnormal_plasma_membrane3.61450542
8MP0005451_abnormal_body_composition3.51186474
9MP0003566_abnormal_cell_adhesion3.39798791
10MP0008875_abnormal_xenobiotic_pharmacok3.12095474
11MP0005257_abnormal_intraocular_pressure3.10838706
12MP0009840_abnormal_foam_cell2.90375156
13MP0010329_abnormal_lipoprotein_level2.67831644
14MP0003252_abnormal_bile_duct2.52756977
15MP0004185_abnormal_adipocyte_glucose2.49700147
16MP0005023_abnormal_wound_healing2.46172199
17MP0003718_maternal_effect2.42022751
18MP0010030_abnormal_orbit_morphology2.38574245
19MP0005623_abnormal_meninges_morphology2.36166241
20MP0000762_abnormal_tongue_morphology2.21162157
21MP0006292_abnormal_olfactory_placode2.17360622
22MP0003693_abnormal_embryo_hatching2.15116244
23MP0003941_abnormal_skin_development2.14942042
24MP0005275_abnormal_skin_tensile2.06804779
25MP0000537_abnormal_urethra_morphology2.03520378
26MP0000751_myopathy2.02670871
27MP0005408_hypopigmentation2.01752272
28MP0010352_gastrointestinal_tract_polyps1.99738469
29MP0009780_abnormal_chondrocyte_physiolo1.90745171
30MP0000013_abnormal_adipose_tissue1.90355364
31MP0000609_abnormal_liver_physiology1.90286132
32MP0005647_abnormal_sex_gland1.88831382
33MP0003806_abnormal_nucleotide_metabolis1.86099461
34MP0003191_abnormal_cellular_cholesterol1.82274846
35MP0006054_spinal_hemorrhage1.80103988
36MP0000749_muscle_degeneration1.71492159
37MP0001958_emphysema1.69766880
38MP0003279_aneurysm1.69758902
39MP0008057_abnormal_DNA_replication1.68835883
40MP0002896_abnormal_bone_mineralization1.67586508
41MP0001849_ear_inflammation1.65387112
42MP0002653_abnormal_ependyma_morphology1.64155484
43MP0001666_abnormal_nutrient_absorption1.59993290
44MP0000003_abnormal_adipose_tissue1.56618047
45MP0005332_abnormal_amino_acid1.55610810
46MP0005395_other_phenotype1.53822790
47MP0002332_abnormal_exercise_endurance1.53656652
48MP0000566_synostosis1.52656975
49MP0003705_abnormal_hypodermis_morpholog1.52357237
50MP0000733_abnormal_muscle_development1.51498425
51MP0005666_abnormal_adipose_tissue1.51318693
52MP0000467_abnormal_esophagus_morphology1.49155094
53MP0003077_abnormal_cell_cycle1.49069704
54MP0002138_abnormal_hepatobiliary_system1.44803872
55MP0004233_abnormal_muscle_weight1.43410292
56MP0010307_abnormal_tumor_latency1.43257627
57MP0005670_abnormal_white_adipose1.43122154
58MP0003111_abnormal_nucleus_morphology1.42600665
59MP0003646_muscle_fatigue1.39920501
60MP0001216_abnormal_epidermal_layer1.39284541
61MP0004264_abnormal_extraembryonic_tissu1.38180149
62MP0001299_abnormal_eye_distance/1.36816494
63MP0002796_impaired_skin_barrier1.36614298
64MP0002118_abnormal_lipid_homeostasis1.35386437
65MP0001542_abnormal_bone_strength1.35156088
66MP0008007_abnormal_cellular_replicative1.34325243
67MP0003303_peritoneal_inflammation1.32535585
68MP0005501_abnormal_skin_physiology1.31573660
69MP0003868_abnormal_feces_composition1.29270380
70MP0009384_cardiac_valve_regurgitation1.28144715
71MP0001661_extended_life_span1.28104735
72MP0004019_abnormal_vitamin_homeostasis1.26940947
73MP0001348_abnormal_lacrimal_gland1.21086616
74MP0001243_abnormal_dermal_layer1.20615071
75MP0001119_abnormal_female_reproductive1.17965611
76MP0003699_abnormal_female_reproductive1.17931413
77MP0005248_abnormal_Harderian_gland1.17751911
78MP0010678_abnormal_skin_adnexa1.17254880
79* MP0005197_abnormal_uvea_morphology1.15563293
80MP0001730_embryonic_growth_arrest1.11299225
81MP0010234_abnormal_vibrissa_follicle1.09580935
82MP0005165_increased_susceptibility_to1.09083685
83MP0004957_abnormal_blastocyst_morpholog1.07896850
84MP0002089_abnormal_postnatal_growth/wei1.05921191
85MP0005508_abnormal_skeleton_morphology1.03463148
86MP0010771_integument_phenotype1.03329703
87MP0005409_darkened_coat_color1.02971130
88MP0005076_abnormal_cell_differentiation1.01075624
89MP0000534_abnormal_ureter_morphology1.00534388
90MP0003755_abnormal_palate_morphology1.00254019
91MP0000759_abnormal_skeletal_muscle1.00201672
92MP0000750_abnormal_muscle_regeneration0.99996553
93MP0005595_abnormal_vascular_smooth0.99384702
94MP0002234_abnormal_pharynx_morphology0.97454987
95MP0001879_abnormal_lymphatic_vessel0.97100108
96MP0005164_abnormal_response_to0.96379973
97MP0002971_abnormal_brown_adipose0.95013077
98MP0001915_intracranial_hemorrhage0.94632912
99MP0005319_abnormal_enzyme/_coenzyme0.94332888
100MP0009115_abnormal_fat_cell0.94243244
101MP0002295_abnormal_pulmonary_circulatio0.93789032
102MP0004858_abnormal_nervous_system0.93622725
103MP0002254_reproductive_system_inflammat0.93173658
104MP0001800_abnormal_humoral_immune0.92849091
105MP0001672_abnormal_embryogenesis/_devel0.92701503
106MP0005380_embryogenesis_phenotype0.92701503
107MP0000639_abnormal_adrenal_gland0.91590133
108MP0005058_abnormal_lysosome_morphology0.91536778
109MP0004130_abnormal_muscle_cell0.90077124
110MP0000598_abnormal_liver_morphology0.89150535
111MP0009250_abnormal_appendicular_skeleto0.87628721
112MP0004510_myositis0.87104659
113MP0000350_abnormal_cell_proliferation0.84882945
114MP0000579_abnormal_nail_morphology0.84615238
115MP0010094_abnormal_chromosome_stability0.84510932
116MP0009333_abnormal_splenocyte_physiolog0.84245530
117MP0004087_abnormal_muscle_fiber0.84150678
118MP0009053_abnormal_anal_canal0.84009771
119MP0008877_abnormal_DNA_methylation0.83688594
120MP0002168_other_aberrant_phenotype0.83131827
121MP0000767_abnormal_smooth_muscle0.82970615
122MP0005330_cardiomyopathy0.82347039
123MP0002102_abnormal_ear_morphology0.82328372
124MP0009643_abnormal_urine_homeostasis0.81520570
125MP0000163_abnormal_cartilage_morphology0.80363268
126MP0006138_congestive_heart_failure0.80107364
127MP0002269_muscular_atrophy0.79294773
128MP0009764_decreased_sensitivity_to0.79180539
129MP0003984_embryonic_growth_retardation0.78887681
130MP0001835_abnormal_antigen_presentation0.78759279
131MP0000858_altered_metastatic_potential0.77962968
132MP0005503_abnormal_tendon_morphology0.77364755
133MP0001881_abnormal_mammary_gland0.77159393
134MP0003937_abnormal_limbs/digits/tail_de0.76176807
135MP0003385_abnormal_body_wall0.76144897
136MP0002098_abnormal_vibrissa_morphology0.75884569
137MP0000627_abnormal_mammary_gland0.75408553
138MP0005083_abnormal_biliary_tract0.75019862
139MP0002088_abnormal_embryonic_growth/wei0.74902522
140MP0003453_abnormal_keratinocyte_physiol0.74518349
141MP0001929_abnormal_gametogenesis0.73266251
142MP0000653_abnormal_sex_gland0.73112023
143MP0000428_abnormal_craniofacial_morphol0.72888488
144MP0009697_abnormal_copulation0.72768230
145MP0003942_abnormal_urinary_system0.72490620
146MP0003828_pulmonary_edema0.72230378
147MP0000432_abnormal_head_morphology0.70969665
148MP0002086_abnormal_extraembryonic_tissu0.70936812
149MP0003091_abnormal_cell_migration0.70184886
150MP0001614_abnormal_blood_vessel0.69514162
151* MP0005193_abnormal_anterior_eye0.69262569
152MP0005375_adipose_tissue_phenotype0.69061913
153MP0002060_abnormal_skin_morphology0.67933794
154MP0005621_abnormal_cell_physiology0.67554345
155MP0003315_abnormal_perineum_morphology0.66993389
156MP0009672_abnormal_birth_weight0.66583647
157MP0000383_abnormal_hair_follicle0.66196161
158MP0009763_increased_sensitivity_to0.65025408
159MP0002113_abnormal_skeleton_development0.64841693
160MP0002972_abnormal_cardiac_muscle0.64705273
161MP0002085_abnormal_embryonic_tissue0.64537497
162MP0000343_altered_response_to0.64496059
163MP0002697_abnormal_eye_size0.64297143
164MP0002136_abnormal_kidney_physiology0.64284922
165MP0002925_abnormal_cardiovascular_devel0.64089339
166MP0005464_abnormal_platelet_physiology0.63904970
167MP0002210_abnormal_sex_determination0.63755334
168MP0002877_abnormal_melanocyte_morpholog0.63080579
169MP0005584_abnormal_enzyme/coenzyme_acti0.62803618
170MP0001764_abnormal_homeostasis0.61924623
171MP0010368_abnormal_lymphatic_system0.60458442
172MP0002452_abnormal_antigen_presenting0.59601658
173MP0002277_abnormal_respiratory_mucosa0.59539043
174MP0003195_calcinosis0.59469839
175MP0001697_abnormal_embryo_size0.58204907
176MP0002019_abnormal_tumor_incidence0.58087843
177MP0005387_immune_system_phenotype0.57275021
178MP0001790_abnormal_immune_system0.57275021

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.87524776
2Deep venous thrombosis (HP:0002625)5.40539988
3Protrusio acetabuli (HP:0003179)4.91117173
4Atrophic scars (HP:0001075)4.90953735
5Sensorimotor neuropathy (HP:0007141)4.88593576
6Myocardial infarction (HP:0001658)4.87569521
7Facial hemangioma (HP:0000329)4.76392809
8Intrahepatic cholestasis (HP:0001406)4.64770991
9Xanthomatosis (HP:0000991)4.34996045
10Prostate neoplasm (HP:0100787)4.07976441
11Abnormality of monocarboxylic acid metabolism (HP:0010996)4.03024362
12Capillary hemangiomas (HP:0005306)3.89158972
13Hypobetalipoproteinemia (HP:0003563)3.79087344
14Fragile skin (HP:0001030)3.78328743
15Complement deficiency (HP:0004431)3.76946812
16Hyperglycinuria (HP:0003108)3.71486501
17Short nail (HP:0001799)3.66721660
18Abnormality of aromatic amino acid family metabolism (HP:0004338)3.65887177
19Hypoalphalipoproteinemia (HP:0003233)3.57458963
20Spontaneous abortion (HP:0005268)3.57441889
21Milia (HP:0001056)3.53665998
22Epidermoid cyst (HP:0200040)3.51665166
23Cervical subluxation (HP:0003308)3.51514569
24Hypolipoproteinemia (HP:0010981)3.45901246
25Joint hemorrhage (HP:0005261)3.44641074
26Arterial tortuosity (HP:0005116)3.44275238
27Vascular tortuosity (HP:0004948)3.39860808
28Hyperglycinemia (HP:0002154)3.28503552
29Birth length less than 3rd percentile (HP:0003561)3.23482715
30Hyperlipoproteinemia (HP:0010980)3.19926595
31Prolonged partial thromboplastin time (HP:0003645)3.18297938
32Vertebral compression fractures (HP:0002953)3.14541176
33Natal tooth (HP:0000695)3.10927375
34Aortic dissection (HP:0002647)3.09082487
35Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.07788976
36Breast hypoplasia (HP:0003187)3.04114523
37Male infertility (HP:0003251)3.03017360
38Spinal rigidity (HP:0003306)3.02799721
39Abnormality of glutamine family amino acid metabolism (HP:0010902)3.01107774
40Abnormality of serine family amino acid metabolism (HP:0010894)3.00994750
41Abnormality of glycine metabolism (HP:0010895)3.00994750
42Papillary thyroid carcinoma (HP:0002895)2.95833616
43Ankle contracture (HP:0006466)2.90844570
44Osteolytic defects of the hand bones (HP:0009699)2.90816552
45Osteolytic defects of the phalanges of the hand (HP:0009771)2.90816552
46Polycythemia (HP:0001901)2.88566953
47Azoospermia (HP:0000027)2.86547871
48Cardiovascular calcification (HP:0011915)2.82659952
49Abnormality of sulfur amino acid metabolism (HP:0004339)2.82140498
50Increased connective tissue (HP:0009025)2.78339845
51Hyperammonemia (HP:0001987)2.77790306
52Reduced subcutaneous adipose tissue (HP:0003758)2.77373149
53Aortic aneurysm (HP:0004942)2.75374585
54Abnormality of complement system (HP:0005339)2.75103167
55Fragile nails (HP:0001808)2.74549845
56Fat malabsorption (HP:0002630)2.73272756
57Pterygium (HP:0001059)2.70970943
58Shawl scrotum (HP:0000049)2.70854812
59Chromosomal breakage induced by crosslinking agents (HP:0003221)2.69312573
60Abnormality of the distal phalanges of the toes (HP:0010182)2.69200217
61Abnormality of purine metabolism (HP:0004352)2.66700147
62Gout (HP:0001997)2.63818078
63Mildly elevated creatine phosphokinase (HP:0008180)2.63446384
64Abnormality of the intrinsic pathway (HP:0010989)2.62141869
65Upper limb amyotrophy (HP:0009129)2.61702911
66Distal upper limb amyotrophy (HP:0007149)2.61702911
67Thick nail (HP:0001805)2.59228756
68Recurrent gram-negative bacterial infections (HP:0005420)2.58152719
69Abnormality of lateral ventricle (HP:0030047)2.58144081
70Oligodactyly (HP:0012165)2.54966148
71Wormian bones (HP:0002645)2.54779792
72Autoimmune thrombocytopenia (HP:0001973)2.53037718
73Distal lower limb amyotrophy (HP:0008944)2.52845564
74Abnormality of the labia minora (HP:0012880)2.52616226
75Entropion (HP:0000621)2.52321223
76Ulnar bowing (HP:0003031)2.52225779
77Chromsome breakage (HP:0040012)2.51552014
78Malnutrition (HP:0004395)2.50538599
79Vascular calcification (HP:0004934)2.48821998
80Abnormality of nucleobase metabolism (HP:0010932)2.48226450
81Abnormality of the common coagulation pathway (HP:0010990)2.45253405
82Hypercholesterolemia (HP:0003124)2.44586101
83Follicular hyperkeratosis (HP:0007502)2.44234176
84Onycholysis (HP:0001806)2.43968502
85Patellar aplasia (HP:0006443)2.43074092
86Alopecia of scalp (HP:0002293)2.41671784
87Abnormality of aspartate family amino acid metabolism (HP:0010899)2.39737027
88Achilles tendon contracture (HP:0001771)2.38301459
89Breast aplasia (HP:0100783)2.38192424
90Mitral stenosis (HP:0001718)2.37800287
91Abnormality of the prostate (HP:0008775)2.37344967
92Oligodactyly (hands) (HP:0001180)2.37123759
93Distal lower limb muscle weakness (HP:0009053)2.34980873
94Broad face (HP:0000283)2.34753162
95Elbow flexion contracture (HP:0002987)2.33707355
96Neonatal short-limb short stature (HP:0008921)2.31440827
97Esophageal varix (HP:0002040)2.30907808
98Cortical dysplasia (HP:0002539)2.30305024
99Plantar hyperkeratosis (HP:0007556)2.29162059
100Abnormality of dentin (HP:0010299)2.24567153
101Nail dystrophy (HP:0008404)2.23306782
102Aplasia/Hypoplasia of the breasts (HP:0010311)2.23081584
103Bladder diverticulum (HP:0000015)2.22664766
104Hepatocellular carcinoma (HP:0001402)2.22658498
105Increased purine levels (HP:0004368)2.22614706
106Hyperuricemia (HP:0002149)2.22614706
107Difficulty climbing stairs (HP:0003551)2.22329393
108Abnormality of carpal bone ossification (HP:0006257)2.22321318
109Shallow orbits (HP:0000586)2.21754284
110Right ventricular cardiomyopathy (HP:0011663)2.21089822
111Blue sclerae (HP:0000592)2.20263969
112Popliteal pterygium (HP:0009756)2.19501336
113Aplasia/Hypoplasia of the patella (HP:0006498)2.18926986
114Nuclear cataract (HP:0100018)2.18893867
115Flat acetabular roof (HP:0003180)2.17777267
116Soft skin (HP:0000977)2.17654334
117Type 1 muscle fiber predominance (HP:0003803)2.17243034
118Abnormality of the fingertips (HP:0001211)2.14640198
119Tibial bowing (HP:0002982)2.12772092
120Abnormal ossification of hand bones (HP:0005921)2.11865767
121Abnormality of methionine metabolism (HP:0010901)2.11367788
122Abnormality of pyrimidine metabolism (HP:0004353)2.11279056
123Abnormal spermatogenesis (HP:0008669)2.08405583
124Glomerulonephritis (HP:0000099)2.08035055
125Abnormality of the Achilles tendon (HP:0005109)2.07423106
126Peritonitis (HP:0002586)2.06938891
127Acute myeloid leukemia (HP:0004808)2.06103780
128Advanced eruption of teeth (HP:0006288)2.04485001
129Generalized amyotrophy (HP:0003700)2.03509531
130Spondylolisthesis (HP:0003302)2.03194270
131Spastic diplegia (HP:0001264)2.01930347
132Mitral regurgitation (HP:0001653)2.01870091
133Colitis (HP:0002583)2.01764397
134Agammaglobulinemia (HP:0004432)2.01026582
135Hemorrhage of the eye (HP:0011885)2.00627142
136Abnormality of the acetabulum (HP:0003170)1.97654725
137Hyperglycemia (HP:0003074)1.94412822
138Abnormality of the umbilical cord (HP:0010881)1.94190093
139Abnormality of the hepatic vasculature (HP:0006707)1.92836050
140Focal segmental glomerulosclerosis (HP:0000097)1.92403399
141Enlarged penis (HP:0000040)1.92075726
142Ankyloglossia (HP:0010296)1.91912476
143Glucose intolerance (HP:0000833)1.91419628
144Gastrointestinal infarctions (HP:0005244)1.91208191
145Steatorrhea (HP:0002570)1.90724916
146Abnormality of oral frenula (HP:0000190)1.90410195
147Cerebral aneurysm (HP:0004944)1.90029866
148Hand muscle atrophy (HP:0009130)1.89580326
149Bowed forearm bones (HP:0003956)1.88235572
150Bowing of the arm (HP:0006488)1.88235572
151Upper motor neuron abnormality (HP:0002127)1.87830099
152Hypochromic microcytic anemia (HP:0004840)1.87534562
153Carpal bone hypoplasia (HP:0001498)1.87300445
154Delayed puberty (HP:0000823)1.86499433
155Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.86480263
156Hyperacusis (HP:0010780)1.86324997
157Abnormality of male internal genitalia (HP:0000022)1.84513783
158Abnormalities of placenta or umbilical cord (HP:0001194)1.81453815
159Impulsivity (HP:0100710)1.81066377
160Coxa vara (HP:0002812)1.80159892
161Axonal loss (HP:0003447)1.80039115
162Abnormal delivery (HP:0001787)1.79512444
163Microglossia (HP:0000171)1.79053251
164Camptodactyly of toe (HP:0001836)1.77871698
165Acanthocytosis (HP:0001927)1.76980740
166Trismus (HP:0000211)1.75224455
167Aplasia cutis congenita (HP:0001057)1.75071638
168Hypoplasia of dental enamel (HP:0006297)1.75005816
169Aortic regurgitation (HP:0001659)1.74933673
170Lower limb amyotrophy (HP:0007210)1.74294053
171Conjugated hyperbilirubinemia (HP:0002908)1.73573790
172Nephritis (HP:0000123)1.72824127
173Knee flexion contracture (HP:0006380)1.72151119
174Abnormal cartilage morphology (HP:0002763)1.71235167
175Abnormal hand bone ossification (HP:0010660)1.70395194
176Limb-girdle muscle atrophy (HP:0003797)1.70124304
177Joint laxity (HP:0001388)1.70028732
178Abnormality of nail color (HP:0100643)1.69884674
179Ketosis (HP:0001946)1.69571865
180Abnormality of serum amino acid levels (HP:0003112)1.67879734
181Mitral valve prolapse (HP:0001634)1.67217764
182Deviation of the thumb (HP:0009603)1.66546952
183Nausea (HP:0002018)1.65873254
184Skin nodule (HP:0200036)1.65560208
185Abnormality of proline metabolism (HP:0010907)1.64335401
186Hydroxyprolinuria (HP:0003080)1.64335401
187Abnormality of fatty-acid metabolism (HP:0004359)1.62381931
188Systemic lupus erythematosus (HP:0002725)1.62215153
189Abnormality of the distal phalanx of the thumb (HP:0009617)1.61863537
190Genu recurvatum (HP:0002816)1.60637052
191Dilatation of the ascending aorta (HP:0005111)1.60133537
192Thin bony cortex (HP:0002753)1.60051377
193Long palpebral fissure (HP:0000637)1.59121794
194Thoracolumbar scoliosis (HP:0002944)1.58874117
195Long toe (HP:0010511)1.56001397
196Palmoplantar hyperkeratosis (HP:0000972)1.54860856
197Glomerulosclerosis (HP:0000096)1.54734002

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS26.01427037
2LATS15.12501626
3STK38L4.07221714
4MET3.39985835
5PTK22.76997958
6ERBB42.56496436
7CDK122.51219293
8STK32.45065149
9EPHB22.44755141
10PDGFRA2.35261415
11MAP3K62.33869015
12TTN2.33561178
13RIPK12.25261064
14PAK42.23106746
15LMTK22.16569476
16TRIB32.10244974
17PIM22.06759007
18FRK1.99825430
19LIMK11.99224332
20KSR21.97140740
21NME21.96063525
22TESK11.95306346
23TGFBR21.93972795
24TAOK31.92525611
25NEK21.89279772
26MYLK1.83003439
27ABL21.80400932
28ERN11.79834512
29ICK1.73203414
30NTRK11.67927916
31CDC71.65540658
32DYRK21.58137575
33CAMK1D1.56709770
34ARAF1.54550707
35TTK1.52111806
36DYRK31.51682527
37ACVR1B1.49334436
38CDK91.49333029
39IRAK31.47546277
40NLK1.46810012
41CDK41.41338974
42BRSK21.40824615
43MOS1.37705609
44PDK21.34558475
45CSNK1G11.34179068
46DDR21.32247039
47STK101.29484220
48PBK1.22214329
49PRKAA21.21284237
50PAK21.20212256
51MAP3K31.18533302
52MAP3K131.18145748
53MELK1.15782532
54PLK41.14256239
55PLK11.13799904
56FLT31.09444742
57MARK31.06388145
58EPHB11.03289239
59WEE11.03177011
60RAF10.99417431
61CHEK20.99211432
62AURKB0.98188526
63MAP4K10.97860244
64TYK20.97742907
65FGFR40.97548035
66TRPM70.94998010
67MAP3K120.94950834
68RPS6KA40.93267492
69STK380.93008019
70SRPK10.92802804
71EPHA30.92111724
72TAOK20.90953556
73CDK80.89584874
74AKT30.86363817
75PRKAA10.85766846
76CDK30.83859652
77PDGFRB0.83851732
78NEK10.82763497
79CDK60.82552576
80SIK10.82059177
81MAPK110.80557666
82JAK30.80360070
83SGK20.79452198
84TYRO30.76467153
85ROCK20.73298967
86PRKD20.72597116
87ABL10.72316842
88TAOK10.71818105
89EEF2K0.71580130
90MST1R0.71057218
91CAMK1G0.70903303
92GRK60.70201448
93JAK20.69397763
94BCKDK0.68817636
95KSR10.68466719
96PTK2B0.68233426
97CDK70.67967380
98ROCK10.65120784
99SGK30.64437102
100PAK60.64326163
101NEK90.63714604
102MUSK0.62926007
103PTK60.62739800
104ILK0.61902482
105MAP3K80.60724572
106JAK10.57603369
107CSF1R0.57536910
108PRKG20.57401402
109DMPK0.56252893
110BMX0.55624105
111ERBB30.54367227
112EPHA20.54089372
113BRAF0.54076001
114MAP3K90.54066938
115SIK30.53926454
116EIF2AK30.52875134
117PHKG10.52487180
118PHKG20.52487180
119DYRK1A0.52382185
120CHEK10.51674690
121FGFR30.51287725
122PRKD30.49748284
123MST40.47195775
124PRKCI0.46007886
125SMG10.45554700
126RPS6KA20.43844793
127CHUK0.43482446
128MAP2K40.42987306
129CDC42BPA0.42771471
130TGFBR10.42016960
131BRSK10.41871449
132EIF2AK20.41009537
133MTOR0.39358866
134CAMK2G0.39056071
135PAK10.39022893
136BUB10.37724860
137PIM10.37380774
138MAP2K10.37378290
139MAP3K50.37308401
140CSNK1G20.35912955
141AKT20.35786951
142MAPK100.35387004
143GRK70.35171456
144BMPR20.35034698
145STK240.34206164
146ATM0.34066395
147CDK20.33991761
148TRIM280.33899622
149CAMK2D0.33636610
150GRK10.33322094
151NUAK10.32628339
152PKN20.32417643
153ERBB20.31945138
154AURKA0.31600678
155ADRBK10.31570621
156MAPKAPK30.30446657
157GSK3A0.30011513
158MAP3K10.29513711
159SGK2230.29092749
160SGK4940.29092749
161FER0.28518112
162SCYL20.27926793
163DAPK30.24875639
164TESK20.24533619

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.66843863
2ECM-receptor interaction_Homo sapiens_hsa045123.47408190
3Nitrogen metabolism_Homo sapiens_hsa009103.36331700
4Arginine biosynthesis_Homo sapiens_hsa002203.06502783
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.89938873
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.77709417
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.71786626
8Focal adhesion_Homo sapiens_hsa045102.66978490
9Complement and coagulation cascades_Homo sapiens_hsa046102.56399174
10Vitamin B6 metabolism_Homo sapiens_hsa007502.33272450
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.29426594
12Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.23423255
13Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.20686358
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.17126026
15Pentose phosphate pathway_Homo sapiens_hsa000302.13300479
16Proteoglycans in cancer_Homo sapiens_hsa052052.10863048
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.10476659
18Tryptophan metabolism_Homo sapiens_hsa003802.08474493
19PPAR signaling pathway_Homo sapiens_hsa033202.03904414
20Bladder cancer_Homo sapiens_hsa052192.02165298
21Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.99537002
22Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.94352654
23Sulfur metabolism_Homo sapiens_hsa009201.90336607
24Fatty acid degradation_Homo sapiens_hsa000711.84518839
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.82703411
26Hippo signaling pathway_Homo sapiens_hsa043901.81546883
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.69891333
28Caffeine metabolism_Homo sapiens_hsa002321.68759108
29Galactose metabolism_Homo sapiens_hsa000521.67045839
30Staphylococcus aureus infection_Homo sapiens_hsa051501.65267250
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.65230614
32Histidine metabolism_Homo sapiens_hsa003401.65058385
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.63958936
34Amoebiasis_Homo sapiens_hsa051461.61388803
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.60767290
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.56442317
37Biosynthesis of amino acids_Homo sapiens_hsa012301.56187847
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.55503458
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.55409090
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.54166332
41Dilated cardiomyopathy_Homo sapiens_hsa054141.52715686
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.51696971
43beta-Alanine metabolism_Homo sapiens_hsa004101.49375645
44Central carbon metabolism in cancer_Homo sapiens_hsa052301.44594184
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.43249919
46Peroxisome_Homo sapiens_hsa041461.39701832
47Regulation of actin cytoskeleton_Homo sapiens_hsa048101.38837998
48Drug metabolism - other enzymes_Homo sapiens_hsa009831.37431141
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.37316907
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.33431675
51Cell cycle_Homo sapiens_hsa041101.30648240
52Chemical carcinogenesis_Homo sapiens_hsa052041.30333038
53Retinol metabolism_Homo sapiens_hsa008301.28314082
54Steroid hormone biosynthesis_Homo sapiens_hsa001401.27470357
55Fat digestion and absorption_Homo sapiens_hsa049751.26874799
56Basal cell carcinoma_Homo sapiens_hsa052171.26019968
57Butanoate metabolism_Homo sapiens_hsa006501.25854216
58Other glycan degradation_Homo sapiens_hsa005111.19208777
59Fructose and mannose metabolism_Homo sapiens_hsa000511.18661798
60Phenylalanine metabolism_Homo sapiens_hsa003601.18626671
61Bile secretion_Homo sapiens_hsa049761.18362945
62PI3K-Akt signaling pathway_Homo sapiens_hsa041511.16692228
63Vitamin digestion and absorption_Homo sapiens_hsa049771.16220230
64Lysine degradation_Homo sapiens_hsa003101.14420615
65Fatty acid metabolism_Homo sapiens_hsa012121.14345381
66Steroid biosynthesis_Homo sapiens_hsa001001.14212058
67Propanoate metabolism_Homo sapiens_hsa006401.12539302
68Chronic myeloid leukemia_Homo sapiens_hsa052201.11833030
69Cysteine and methionine metabolism_Homo sapiens_hsa002701.11072866
70Thyroid cancer_Homo sapiens_hsa052161.10021732
71N-Glycan biosynthesis_Homo sapiens_hsa005101.09978972
72Hedgehog signaling pathway_Homo sapiens_hsa043401.09299652
73Salmonella infection_Homo sapiens_hsa051321.09032732
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08016481
75Vibrio cholerae infection_Homo sapiens_hsa051101.07303911
76Arginine and proline metabolism_Homo sapiens_hsa003301.06253479
77Shigellosis_Homo sapiens_hsa051311.06236942
78Selenocompound metabolism_Homo sapiens_hsa004501.05336085
79Tyrosine metabolism_Homo sapiens_hsa003501.05005484
80Prion diseases_Homo sapiens_hsa050201.04302629
81Tight junction_Homo sapiens_hsa045301.02352817
82Folate biosynthesis_Homo sapiens_hsa007901.02037991
83Glycerolipid metabolism_Homo sapiens_hsa005610.99541670
84Sulfur relay system_Homo sapiens_hsa041220.97030994
85Pathways in cancer_Homo sapiens_hsa052000.96800794
86Protein digestion and absorption_Homo sapiens_hsa049740.95291945
87TNF signaling pathway_Homo sapiens_hsa046680.92495177
88Basal transcription factors_Homo sapiens_hsa030220.91933141
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91210293
90Lysosome_Homo sapiens_hsa041420.90963771
91Circadian rhythm_Homo sapiens_hsa047100.87636444
92Fatty acid biosynthesis_Homo sapiens_hsa000610.87161702
93Axon guidance_Homo sapiens_hsa043600.85593341
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85148334
95Carbon metabolism_Homo sapiens_hsa012000.85049621
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83277569
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82114538
98Melanoma_Homo sapiens_hsa052180.78686209
99TGF-beta signaling pathway_Homo sapiens_hsa043500.75555263
100Fatty acid elongation_Homo sapiens_hsa000620.75477758
101Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.74681393
102Starch and sucrose metabolism_Homo sapiens_hsa005000.74435183
103Pancreatic cancer_Homo sapiens_hsa052120.74082805
104One carbon pool by folate_Homo sapiens_hsa006700.73982102
105Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.73566150
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.71741308
107Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71180813
108Endocytosis_Homo sapiens_hsa041440.71101179
109Insulin resistance_Homo sapiens_hsa049310.68989655
110Pyruvate metabolism_Homo sapiens_hsa006200.68642547
111Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68350865
112ABC transporters_Homo sapiens_hsa020100.63578765
113ErbB signaling pathway_Homo sapiens_hsa040120.63487551
114Apoptosis_Homo sapiens_hsa042100.62175145
1152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62151829
116RNA polymerase_Homo sapiens_hsa030200.61808714
117Wnt signaling pathway_Homo sapiens_hsa043100.61258954
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.61176967
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61083994
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.60667305
121B cell receptor signaling pathway_Homo sapiens_hsa046620.60530829
122p53 signaling pathway_Homo sapiens_hsa041150.60503758
123NF-kappa B signaling pathway_Homo sapiens_hsa040640.60167958
124Intestinal immune network for IgA production_Homo sapiens_hsa046720.59718676
125alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58508408
126AMPK signaling pathway_Homo sapiens_hsa041520.55930703
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54799995
128Insulin signaling pathway_Homo sapiens_hsa049100.54160620
129MicroRNAs in cancer_Homo sapiens_hsa052060.53851664
130Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53098661
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53086483
132Fanconi anemia pathway_Homo sapiens_hsa034600.52853303
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52830207
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50209101
135Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.49987207
136Melanogenesis_Homo sapiens_hsa049160.49465404
137Small cell lung cancer_Homo sapiens_hsa052220.47745407
138Dorso-ventral axis formation_Homo sapiens_hsa043200.47065082
139Herpes simplex infection_Homo sapiens_hsa051680.44091777
140Toxoplasmosis_Homo sapiens_hsa051450.43739345
141Adherens junction_Homo sapiens_hsa045200.43722430
142Ovarian steroidogenesis_Homo sapiens_hsa049130.43363873
143Glioma_Homo sapiens_hsa052140.42273826
144Glucagon signaling pathway_Homo sapiens_hsa049220.42131945
145Rap1 signaling pathway_Homo sapiens_hsa040150.41380968
146Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41225618
147Glutathione metabolism_Homo sapiens_hsa004800.41040057
148Notch signaling pathway_Homo sapiens_hsa043300.40099400
149Linoleic acid metabolism_Homo sapiens_hsa005910.40037289
150Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39981218
151Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38990290
152Hepatitis C_Homo sapiens_hsa051600.37012934
153FoxO signaling pathway_Homo sapiens_hsa040680.35534944
154Maturity onset diabetes of the young_Homo sapiens_hsa049500.35379480
155Pertussis_Homo sapiens_hsa051330.34566990
156Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34447646
157Endometrial cancer_Homo sapiens_hsa052130.34386306
158Prostate cancer_Homo sapiens_hsa052150.33524929
159Choline metabolism in cancer_Homo sapiens_hsa052310.31014472
160RNA transport_Homo sapiens_hsa030130.30856160
161mTOR signaling pathway_Homo sapiens_hsa041500.28256062
162Renal cell carcinoma_Homo sapiens_hsa052110.27938464
163Prolactin signaling pathway_Homo sapiens_hsa049170.27304893
164Hepatitis B_Homo sapiens_hsa051610.26918054
165RNA degradation_Homo sapiens_hsa030180.25974353
166Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.21849291
167Oocyte meiosis_Homo sapiens_hsa041140.21628257
168Sphingolipid metabolism_Homo sapiens_hsa006000.21308125

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