

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | proteasome assembly (GO:0043248) | 4.89246759 |
| 2 | ribosomal small subunit assembly (GO:0000028) | 4.57750382 |
| 3 | maturation of SSU-rRNA (GO:0030490) | 4.50796829 |
| 4 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.43140090 |
| 5 | DNA double-strand break processing (GO:0000729) | 4.36204422 |
| 6 | ribosomal small subunit biogenesis (GO:0042274) | 4.35955468 |
| 7 | DNA deamination (GO:0045006) | 4.30199744 |
| 8 | formation of translation preinitiation complex (GO:0001731) | 4.29855823 |
| 9 | ribosomal large subunit biogenesis (GO:0042273) | 4.27606438 |
| 10 | viral transcription (GO:0019083) | 4.25826956 |
| 11 | translational termination (GO:0006415) | 4.19897877 |
| 12 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.18835157 |
| 13 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.15361027 |
| 14 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.06035148 |
| 15 | DNA replication initiation (GO:0006270) | 3.99445197 |
| 16 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.98827403 |
| 17 | DNA strand elongation (GO:0022616) | 3.97865521 |
| 18 | mitotic metaphase plate congression (GO:0007080) | 3.92011269 |
| 19 | DNA replication checkpoint (GO:0000076) | 3.91402872 |
| 20 | protein neddylation (GO:0045116) | 3.89321835 |
| 21 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.88632082 |
| 22 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.87880073 |
| 23 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.87019283 |
| 24 | CENP-A containing nucleosome assembly (GO:0034080) | 3.82658020 |
| 25 | translational elongation (GO:0006414) | 3.82419539 |
| 26 | translational initiation (GO:0006413) | 3.82392125 |
| 27 | chromatin remodeling at centromere (GO:0031055) | 3.81999400 |
| 28 | ribosome biogenesis (GO:0042254) | 3.79765592 |
| 29 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.78009337 |
| 30 | cullin deneddylation (GO:0010388) | 3.75850541 |
| 31 | spliceosomal snRNP assembly (GO:0000387) | 3.75735682 |
| 32 | telomere maintenance via recombination (GO:0000722) | 3.75313638 |
| 33 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.69156023 |
| 34 | negative regulation of ligase activity (GO:0051352) | 3.69147578 |
| 35 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.69147578 |
| 36 | ATP synthesis coupled proton transport (GO:0015986) | 3.64836562 |
| 37 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.64836562 |
| 38 | DNA damage response, detection of DNA damage (GO:0042769) | 3.64139866 |
| 39 | ribosome assembly (GO:0042255) | 3.63555011 |
| 40 | cotranslational protein targeting to membrane (GO:0006613) | 3.63004898 |
| 41 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.59329312 |
| 42 | termination of RNA polymerase III transcription (GO:0006386) | 3.59329312 |
| 43 | protein targeting to ER (GO:0045047) | 3.59136427 |
| 44 | nucleobase biosynthetic process (GO:0046112) | 3.58465274 |
| 45 | rRNA processing (GO:0006364) | 3.55139601 |
| 46 | chaperone-mediated protein transport (GO:0072321) | 3.52385201 |
| 47 | mitotic recombination (GO:0006312) | 3.51867894 |
| 48 | protein deneddylation (GO:0000338) | 3.51275621 |
| 49 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.50445337 |
| 50 | purine nucleobase biosynthetic process (GO:0009113) | 3.50394286 |
| 51 | telomere maintenance via telomere lengthening (GO:0010833) | 3.49553964 |
| 52 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.48693581 |
| 53 | translation (GO:0006412) | 3.48157765 |
| 54 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.47962256 |
| 55 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.45858234 |
| 56 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.45858234 |
| 57 | kinetochore assembly (GO:0051382) | 3.45849170 |
| 58 | respiratory chain complex IV assembly (GO:0008535) | 3.45497729 |
| 59 | spliceosomal complex assembly (GO:0000245) | 3.43531975 |
| 60 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.43300003 |
| 61 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.43300003 |
| 62 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.43300003 |
| 63 | rRNA metabolic process (GO:0016072) | 3.43234144 |
| 64 | 7-methylguanosine mRNA capping (GO:0006370) | 3.43178486 |
| 65 | cellular protein complex disassembly (GO:0043624) | 3.43012898 |
| 66 | kinetochore organization (GO:0051383) | 3.42369224 |
| 67 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.42249981 |
| 68 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.42249981 |
| 69 | DNA replication-independent nucleosome organization (GO:0034724) | 3.41485587 |
| 70 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.41485587 |
| 71 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.40466699 |
| 72 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.40466699 |
| 73 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.40018051 |
| 74 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.40018051 |
| 75 | protein localization to endoplasmic reticulum (GO:0070972) | 3.39970051 |
| 76 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.39452484 |
| 77 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.38995014 |
| 78 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.38768936 |
| 79 | 7-methylguanosine RNA capping (GO:0009452) | 3.37626756 |
| 80 | RNA capping (GO:0036260) | 3.37626756 |
| 81 | protein complex biogenesis (GO:0070271) | 3.37569113 |
| 82 | metaphase plate congression (GO:0051310) | 3.34638621 |
| 83 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.34167974 |
| 84 | viral life cycle (GO:0019058) | 3.34142477 |
| 85 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.33590723 |
| 86 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.33468515 |
| 87 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.33308926 |
| 88 | respiratory electron transport chain (GO:0022904) | 3.32749667 |
| 89 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.32004503 |
| 90 | NADH dehydrogenase complex assembly (GO:0010257) | 3.32004503 |
| 91 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.32004503 |
| 92 | positive regulation of ligase activity (GO:0051351) | 3.31122943 |
| 93 | DNA ligation (GO:0006266) | 3.31016894 |
| 94 | establishment of integrated proviral latency (GO:0075713) | 3.29880299 |
| 95 | electron transport chain (GO:0022900) | 3.28854897 |
| 96 | viral mRNA export from host cell nucleus (GO:0046784) | 3.28482738 |
| 97 | organelle disassembly (GO:1903008) | 3.27752256 |
| 98 | rRNA modification (GO:0000154) | 3.27610534 |
| 99 | cellular component biogenesis (GO:0044085) | 3.26672638 |
| 100 | regulation of helicase activity (GO:0051095) | 3.24576124 |
| 101 | histone exchange (GO:0043486) | 3.24208492 |
| 102 | maturation of 5.8S rRNA (GO:0000460) | 3.23040414 |
| 103 | IMP biosynthetic process (GO:0006188) | 3.22524174 |
| 104 | pseudouridine synthesis (GO:0001522) | 3.20222680 |
| 105 | histone mRNA metabolic process (GO:0008334) | 3.18869084 |
| 106 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.14983885 |
| 107 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.14309298 |
| 108 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.14291076 |
| 109 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.14239724 |
| 110 | regulation of centriole replication (GO:0046599) | 3.13544911 |
| 111 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.12066342 |
| 112 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.09944256 |
| 113 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.09944256 |
| 114 | termination of RNA polymerase I transcription (GO:0006363) | 3.09567397 |
| 115 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.09064325 |
| 116 | DNA unwinding involved in DNA replication (GO:0006268) | 3.08609937 |
| 117 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.08194227 |
| 118 | cell cycle G1/S phase transition (GO:0044843) | 3.08194227 |
| 119 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.08096042 |
| 120 | protein complex disassembly (GO:0043241) | 3.07205488 |
| 121 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.04609988 |
| 122 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.04609988 |
| 123 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.04609988 |
| 124 | negative regulation of sister chromatid segregation (GO:0033046) | 3.04609988 |
| 125 | negative regulation of chromosome segregation (GO:0051985) | 3.04184456 |
| 126 | protein targeting to mitochondrion (GO:0006626) | 3.02765477 |
| 127 | ribonucleoprotein complex disassembly (GO:0032988) | 3.00279967 |
| 128 | cytochrome complex assembly (GO:0017004) | 2.96845689 |
| 129 | regulation of ligase activity (GO:0051340) | 2.96628815 |
| 130 | protein localization to mitochondrion (GO:0070585) | 2.95546492 |
| 131 | establishment of viral latency (GO:0019043) | 2.94067727 |
| 132 | protein localization to kinetochore (GO:0034501) | 2.93004895 |
| 133 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 2.91578162 |
| 134 | isotype switching (GO:0045190) | 2.91578162 |
| 135 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 2.91578162 |
| 136 | peptidyl-histidine modification (GO:0018202) | 2.85746360 |
| 137 | negative regulation of DNA recombination (GO:0045910) | 2.84844977 |
| 138 | regulation of mitochondrial translation (GO:0070129) | 2.84668874 |
| 139 | establishment of protein localization to mitochondrion (GO:0072655) | 2.84365683 |
| 140 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 2.84292913 |
| 141 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.83290453 |
| 142 | histone H2A acetylation (GO:0043968) | 2.81715824 |
| 143 | postreplication repair (GO:0006301) | 2.81289638 |
| 144 | rRNA methylation (GO:0031167) | 2.78936401 |
| 145 | protein-cofactor linkage (GO:0018065) | 2.77978589 |
| 146 | oxidative phosphorylation (GO:0006119) | 2.76845544 |
| 147 | replication fork processing (GO:0031297) | 2.76473948 |
| 148 | IMP metabolic process (GO:0046040) | 2.76108939 |
| 149 | non-recombinational repair (GO:0000726) | 2.73393610 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 6.53472076 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.63015926 |
| 3 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.11030415 |
| 4 | * GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.70859917 |
| 5 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.68942577 |
| 6 | * EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.64976493 |
| 7 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.54954038 |
| 8 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.37514504 |
| 9 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.36988675 |
| 10 | * MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.25408283 |
| 11 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.12940634 |
| 12 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.09027643 |
| 13 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 3.06907622 |
| 14 | * CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.01141033 |
| 15 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.94016649 |
| 16 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.90822301 |
| 17 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.84002296 |
| 18 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.81841295 |
| 19 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.56625745 |
| 20 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.56544342 |
| 21 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.53469852 |
| 22 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.50407016 |
| 23 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.49521184 |
| 24 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.30974773 |
| 25 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.29588997 |
| 26 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.28749347 |
| 27 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.23588837 |
| 28 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.20185623 |
| 29 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.15386553 |
| 30 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.13272373 |
| 31 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.08898821 |
| 32 | * MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 2.07682850 |
| 33 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.05070236 |
| 34 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.04315994 |
| 35 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.98637156 |
| 36 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.94052357 |
| 37 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.92656441 |
| 38 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.92159662 |
| 39 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.91169672 |
| 40 | * ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.87116753 |
| 41 | * EWS_26573619_Chip-Seq_HEK293_Human | 1.87000746 |
| 42 | * YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.84409882 |
| 43 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.83063039 |
| 44 | * PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.81960264 |
| 45 | FUS_26573619_Chip-Seq_HEK293_Human | 1.80774608 |
| 46 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.75540571 |
| 47 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.75172433 |
| 48 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.75118846 |
| 49 | * SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.74644678 |
| 50 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.73722164 |
| 51 | VDR_22108803_ChIP-Seq_LS180_Human | 1.73716101 |
| 52 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.71343594 |
| 53 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.69427777 |
| 54 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.61574268 |
| 55 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.59905622 |
| 56 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.59266776 |
| 57 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.58183881 |
| 58 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.53902227 |
| 59 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.53211213 |
| 60 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.53176568 |
| 61 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.52155809 |
| 62 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.49737083 |
| 63 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.48186252 |
| 64 | * HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.47753873 |
| 65 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.42786701 |
| 66 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.37909365 |
| 67 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.36944599 |
| 68 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.35623549 |
| 69 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.35158572 |
| 70 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.35045803 |
| 71 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.32961889 |
| 72 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.32658612 |
| 73 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.31214306 |
| 74 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.29291705 |
| 75 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.24524559 |
| 76 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.24245562 |
| 77 | P300_19829295_ChIP-Seq_ESCs_Human | 1.24138565 |
| 78 | * SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.23212693 |
| 79 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.22160884 |
| 80 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.20699630 |
| 81 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.18379441 |
| 82 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.17599762 |
| 83 | * ER_23166858_ChIP-Seq_MCF-7_Human | 1.16436385 |
| 84 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.16272099 |
| 85 | * ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.15728882 |
| 86 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.15702564 |
| 87 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.15134307 |
| 88 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.15048030 |
| 89 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.14024958 |
| 90 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.11444016 |
| 91 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.10363309 |
| 92 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.10057102 |
| 93 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.08573483 |
| 94 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.06435944 |
| 95 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.06230652 |
| 96 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.06036162 |
| 97 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.06036162 |
| 98 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.06036162 |
| 99 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.05573735 |
| 100 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.05407070 |
| 101 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.04971763 |
| 102 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.04442175 |
| 103 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.04433571 |
| 104 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.04295138 |
| 105 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.02495992 |
| 106 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.00393235 |
| 107 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.99329131 |
| 108 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.98908633 |
| 109 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.98801070 |
| 110 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.98263425 |
| 111 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.96768455 |
| 112 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.96324699 |
| 113 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.94833320 |
| 114 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.94557180 |
| 115 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.93230965 |
| 116 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.92772315 |
| 117 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.92351042 |
| 118 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.92185715 |
| 119 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.88840270 |
| 120 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.88530581 |
| 121 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 0.88348586 |
| 122 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.88199843 |
| 123 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.86949675 |
| 124 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.85887961 |
| 125 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.85553916 |
| 126 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.84778632 |
| 127 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.84652733 |
| 128 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.84503775 |
| 129 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.81938099 |
| 130 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.80725096 |
| 131 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.80440401 |
| 132 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.78827700 |
| 133 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.78173144 |
| 134 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.77506701 |
| 135 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.75701989 |
| 136 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.74548740 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.56397606 |
| 2 | MP0004957_abnormal_blastocyst_morpholog | 4.52664508 |
| 3 | MP0003111_abnormal_nucleus_morphology | 4.34970046 |
| 4 | MP0010094_abnormal_chromosome_stability | 4.34480099 |
| 5 | MP0008058_abnormal_DNA_repair | 3.96125386 |
| 6 | MP0003077_abnormal_cell_cycle | 3.85220820 |
| 7 | MP0008057_abnormal_DNA_replication | 3.51750877 |
| 8 | MP0008932_abnormal_embryonic_tissue | 3.05972849 |
| 9 | MP0008877_abnormal_DNA_methylation | 3.03225938 |
| 10 | MP0008007_abnormal_cellular_replicative | 2.73545398 |
| 11 | MP0003123_paternal_imprinting | 2.64114394 |
| 12 | MP0003786_premature_aging | 2.46200437 |
| 13 | MP0006292_abnormal_olfactory_placode | 2.25087387 |
| 14 | MP0003718_maternal_effect | 2.23960122 |
| 15 | MP0002736_abnormal_nociception_after | 2.16913391 |
| 16 | MP0009697_abnormal_copulation | 2.08349058 |
| 17 | MP0001730_embryonic_growth_arrest | 2.01246831 |
| 18 | MP0003880_abnormal_central_pattern | 1.99931195 |
| 19 | MP0000350_abnormal_cell_proliferation | 1.91530713 |
| 20 | MP0004133_heterotaxia | 1.90505409 |
| 21 | MP0010030_abnormal_orbit_morphology | 1.82628097 |
| 22 | MP0003315_abnormal_perineum_morphology | 1.72315882 |
| 23 | MP0002210_abnormal_sex_determination | 1.70123169 |
| 24 | MP0003121_genomic_imprinting | 1.58659761 |
| 25 | MP0003195_calcinosis | 1.58165175 |
| 26 | MP0009379_abnormal_foot_pigmentation | 1.57085494 |
| 27 | MP0001697_abnormal_embryo_size | 1.50606622 |
| 28 | MP0005253_abnormal_eye_physiology | 1.45287518 |
| 29 | MP0001145_abnormal_male_reproductive | 1.44379084 |
| 30 | MP0002653_abnormal_ependyma_morphology | 1.43546295 |
| 31 | MP0008789_abnormal_olfactory_epithelium | 1.42733778 |
| 32 | MP0002160_abnormal_reproductive_system | 1.41015799 |
| 33 | MP0002085_abnormal_embryonic_tissue | 1.40376717 |
| 34 | MP0000372_irregular_coat_pigmentation | 1.40307712 |
| 35 | MP0001984_abnormal_olfaction | 1.40266260 |
| 36 | MP0001672_abnormal_embryogenesis/_devel | 1.37508422 |
| 37 | MP0005380_embryogenesis_phenotype | 1.37508422 |
| 38 | MP0000313_abnormal_cell_death | 1.37153099 |
| 39 | MP0002080_prenatal_lethality | 1.37105886 |
| 40 | MP0001968_abnormal_touch/_nociception | 1.34951157 |
| 41 | MP0001929_abnormal_gametogenesis | 1.34355756 |
| 42 | MP0001293_anophthalmia | 1.32936679 |
| 43 | MP0003941_abnormal_skin_development | 1.32235441 |
| 44 | MP0005551_abnormal_eye_electrophysiolog | 1.31029503 |
| 45 | MP0002090_abnormal_vision | 1.28919080 |
| 46 | MP0005646_abnormal_pituitary_gland | 1.28120985 |
| 47 | MP0002084_abnormal_developmental_patter | 1.27647176 |
| 48 | MP0002837_dystrophic_cardiac_calcinosis | 1.26295724 |
| 49 | MP0000490_abnormal_crypts_of | 1.26248308 |
| 50 | MP0002102_abnormal_ear_morphology | 1.25876999 |
| 51 | MP0003119_abnormal_digestive_system | 1.25267191 |
| 52 | MP0003136_yellow_coat_color | 1.25075997 |
| 53 | MP0003011_delayed_dark_adaptation | 1.24388510 |
| 54 | MP0006035_abnormal_mitochondrial_morpho | 1.24053336 |
| 55 | MP0000653_abnormal_sex_gland | 1.23094729 |
| 56 | MP0009046_muscle_twitch | 1.22748111 |
| 57 | MP0003890_abnormal_embryonic-extraembry | 1.19957644 |
| 58 | MP0002938_white_spotting | 1.19220742 |
| 59 | MP0001764_abnormal_homeostasis | 1.17756907 |
| 60 | MP0003806_abnormal_nucleotide_metabolis | 1.17607406 |
| 61 | MP0005389_reproductive_system_phenotype | 1.17591088 |
| 62 | MP0002396_abnormal_hematopoietic_system | 1.16521237 |
| 63 | MP0001188_hyperpigmentation | 1.16377287 |
| 64 | MP0006276_abnormal_autonomic_nervous | 1.15862617 |
| 65 | MP0002751_abnormal_autonomic_nervous | 1.11446772 |
| 66 | MP0001529_abnormal_vocalization | 1.11325870 |
| 67 | MP0003984_embryonic_growth_retardation | 1.11036107 |
| 68 | MP0002019_abnormal_tumor_incidence | 1.09754810 |
| 69 | MP0002088_abnormal_embryonic_growth/wei | 1.08616875 |
| 70 | MP0000566_synostosis | 1.07186769 |
| 71 | MP0006036_abnormal_mitochondrial_physio | 1.06201067 |
| 72 | MP0008872_abnormal_physiological_respon | 1.06085073 |
| 73 | MP0003186_abnormal_redox_activity | 1.05517308 |
| 74 | MP0005499_abnormal_olfactory_system | 1.05503495 |
| 75 | MP0005394_taste/olfaction_phenotype | 1.05503495 |
| 76 | MP0000358_abnormal_cell_content/ | 1.05449538 |
| 77 | MP0008995_early_reproductive_senescence | 1.02334320 |
| 78 | MP0000647_abnormal_sebaceous_gland | 1.02149255 |
| 79 | MP0002234_abnormal_pharynx_morphology | 1.01959421 |
| 80 | MP0003567_abnormal_fetal_cardiomyocyte | 1.00162677 |
| 81 | MP0008875_abnormal_xenobiotic_pharmacok | 0.99310504 |
| 82 | MP0006072_abnormal_retinal_apoptosis | 0.98386727 |
| 83 | MP0009333_abnormal_splenocyte_physiolog | 0.98378216 |
| 84 | MP0010386_abnormal_urinary_bladder | 0.97464639 |
| 85 | MP0008260_abnormal_autophagy | 0.96820040 |
| 86 | MP0003698_abnormal_male_reproductive | 0.95875512 |
| 87 | MP0004197_abnormal_fetal_growth/weight/ | 0.95145382 |
| 88 | MP0005075_abnormal_melanosome_morpholog | 0.92267111 |
| 89 | MP0002086_abnormal_extraembryonic_tissu | 0.91497410 |
| 90 | MP0004215_abnormal_myocardial_fiber | 0.91399769 |
| 91 | MP0000631_abnormal_neuroendocrine_gland | 0.90368328 |
| 92 | MP0001119_abnormal_female_reproductive | 0.89703430 |
| 93 | MP0000427_abnormal_hair_cycle | 0.88659809 |
| 94 | MP0001919_abnormal_reproductive_system | 0.87677063 |
| 95 | MP0001286_abnormal_eye_development | 0.86389530 |
| 96 | MP0002638_abnormal_pupillary_reflex | 0.85339416 |
| 97 | MP0001177_atelectasis | 0.84872688 |
| 98 | MP0001486_abnormal_startle_reflex | 0.84714989 |
| 99 | MP0001485_abnormal_pinna_reflex | 0.83388607 |
| 100 | MP0000049_abnormal_middle_ear | 0.83195520 |
| 101 | MP0002277_abnormal_respiratory_mucosa | 0.82376634 |
| 102 | MP0002272_abnormal_nervous_system | 0.82185763 |
| 103 | MP0003937_abnormal_limbs/digits/tail_de | 0.82169354 |
| 104 | MP0010352_gastrointestinal_tract_polyps | 0.81398937 |
| 105 | MP0009745_abnormal_behavioral_response | 0.80657291 |
| 106 | MP0005187_abnormal_penis_morphology | 0.79724868 |
| 107 | MP0005410_abnormal_fertilization | 0.79652851 |
| 108 | MP0005367_renal/urinary_system_phenotyp | 0.79506393 |
| 109 | MP0000516_abnormal_urinary_system | 0.79506393 |
| 110 | MP0005645_abnormal_hypothalamus_physiol | 0.79008294 |
| 111 | MP0005084_abnormal_gallbladder_morpholo | 0.78619425 |
| 112 | MP0010307_abnormal_tumor_latency | 0.75933692 |
| 113 | MP0005391_vision/eye_phenotype | 0.75249706 |
| 114 | MP0002111_abnormal_tail_morphology | 0.74610774 |
| 115 | MP0002734_abnormal_mechanical_nocicepti | 0.73882979 |
| 116 | MP0002132_abnormal_respiratory_system | 0.72384692 |
| 117 | MP0003221_abnormal_cardiomyocyte_apopto | 0.72271120 |
| 118 | MP0002184_abnormal_innervation | 0.70548683 |
| 119 | MP0005423_abnormal_somatic_nervous | 0.69965893 |
| 120 | MP0003861_abnormal_nervous_system | 0.69887241 |
| 121 | MP0000703_abnormal_thymus_morphology | 0.69822318 |
| 122 | MP0003137_abnormal_impulse_conducting | 0.68609128 |
| 123 | MP0005384_cellular_phenotype | 0.68606312 |
| 124 | MP0004142_abnormal_muscle_tone | 0.68364111 |
| 125 | MP0000537_abnormal_urethra_morphology | 0.68323917 |
| 126 | MP0002161_abnormal_fertility/fecundity | 0.67882313 |
| 127 | MP0003938_abnormal_ear_development | 0.66969681 |
| 128 | MP0002095_abnormal_skin_pigmentation | 0.65926977 |
| 129 | MP0003787_abnormal_imprinting | 0.60665714 |
| 130 | MP0001727_abnormal_embryo_implantation | 0.55853022 |
| 131 | MP0003755_abnormal_palate_morphology | 0.55250473 |
| 132 | MP0003936_abnormal_reproductive_system | 0.54772587 |
| 133 | MP0002114_abnormal_axial_skeleton | 0.54343258 |
| 134 | MP0004147_increased_porphyrin_level | 0.54023683 |
| 135 | MP0002163_abnormal_gland_morphology | 0.53613149 |
| 136 | MP0003763_abnormal_thymus_physiology | 0.53590292 |
| 137 | MP0009672_abnormal_birth_weight | 0.53265117 |
| 138 | MP0001186_pigmentation_phenotype | 0.52875814 |
| 139 | MP0005395_other_phenotype | 0.52557707 |
| 140 | MP0004808_abnormal_hematopoietic_stem | 0.51729192 |
| 141 | MP0009053_abnormal_anal_canal | 0.50115250 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Birth length less than 3rd percentile (HP:0003561) | 4.94397020 |
| 2 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.47821502 |
| 3 | Reticulocytopenia (HP:0001896) | 4.23516075 |
| 4 | Abnormal number of erythroid precursors (HP:0012131) | 4.16878307 |
| 5 | Breast hypoplasia (HP:0003187) | 3.78417300 |
| 6 | Oral leukoplakia (HP:0002745) | 3.41830787 |
| 7 | Cerebral hypomyelination (HP:0006808) | 3.41434607 |
| 8 | Patellar aplasia (HP:0006443) | 3.40823641 |
| 9 | Aplasia/Hypoplasia of the patella (HP:0006498) | 3.26828150 |
| 10 | Abnormality of the labia minora (HP:0012880) | 3.24626778 |
| 11 | Macrocytic anemia (HP:0001972) | 3.21006886 |
| 12 | Degeneration of anterior horn cells (HP:0002398) | 3.18295660 |
| 13 | Abnormality of the anterior horn cell (HP:0006802) | 3.18295660 |
| 14 | Supernumerary spleens (HP:0009799) | 3.14534198 |
| 15 | Carpal bone hypoplasia (HP:0001498) | 3.10160647 |
| 16 | Cerebral edema (HP:0002181) | 3.04695750 |
| 17 | Rough bone trabeculation (HP:0100670) | 3.04247076 |
| 18 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.03582592 |
| 19 | Chromsome breakage (HP:0040012) | 3.02442062 |
| 20 | Acute necrotizing encephalopathy (HP:0006965) | 3.02095976 |
| 21 | Colon cancer (HP:0003003) | 2.95926702 |
| 22 | Meckel diverticulum (HP:0002245) | 2.94464799 |
| 23 | Pallor (HP:0000980) | 2.89928575 |
| 24 | Abnormality of the preputium (HP:0100587) | 2.89285672 |
| 25 | Abnormality of the ileum (HP:0001549) | 2.86385635 |
| 26 | Absent thumb (HP:0009777) | 2.86014859 |
| 27 | Absent radius (HP:0003974) | 2.85490461 |
| 28 | Hypothermia (HP:0002045) | 2.82202061 |
| 29 | Aplastic anemia (HP:0001915) | 2.81506237 |
| 30 | Methylmalonic acidemia (HP:0002912) | 2.77512492 |
| 31 | Mitochondrial inheritance (HP:0001427) | 2.75503772 |
| 32 | Microretrognathia (HP:0000308) | 2.70888264 |
| 33 | Aplasia involving forearm bones (HP:0009822) | 2.70305634 |
| 34 | Absent forearm bone (HP:0003953) | 2.70305634 |
| 35 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.66714230 |
| 36 | 3-Methylglutaconic aciduria (HP:0003535) | 2.62476694 |
| 37 | Premature graying of hair (HP:0002216) | 2.59090924 |
| 38 | Increased CSF lactate (HP:0002490) | 2.57720383 |
| 39 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.55296677 |
| 40 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.55155993 |
| 41 | Lactic acidosis (HP:0003128) | 2.53549352 |
| 42 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.51570458 |
| 43 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.51570458 |
| 44 | Increased serum lactate (HP:0002151) | 2.48698045 |
| 45 | Renal Fanconi syndrome (HP:0001994) | 2.47410102 |
| 46 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.46060456 |
| 47 | Microvesicular hepatic steatosis (HP:0001414) | 2.45983285 |
| 48 | Abnormality of chromosome stability (HP:0003220) | 2.45174551 |
| 49 | Increased hepatocellular lipid droplets (HP:0006565) | 2.43492171 |
| 50 | Abnormal lung lobation (HP:0002101) | 2.40501781 |
| 51 | Medulloblastoma (HP:0002885) | 2.40481403 |
| 52 | Hepatocellular necrosis (HP:0001404) | 2.40475344 |
| 53 | Hyperglycinemia (HP:0002154) | 2.40144648 |
| 54 | Horseshoe kidney (HP:0000085) | 2.39606384 |
| 55 | Triphalangeal thumb (HP:0001199) | 2.39106376 |
| 56 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.36397515 |
| 57 | Trismus (HP:0000211) | 2.35878855 |
| 58 | Small intestinal stenosis (HP:0012848) | 2.32197247 |
| 59 | Duodenal stenosis (HP:0100867) | 2.32197247 |
| 60 | Abnormality of serum amino acid levels (HP:0003112) | 2.31907985 |
| 61 | Abnormality of methionine metabolism (HP:0010901) | 2.31046234 |
| 62 | Bone marrow hypocellularity (HP:0005528) | 2.31002243 |
| 63 | Cleft eyelid (HP:0000625) | 2.30964121 |
| 64 | Selective tooth agenesis (HP:0001592) | 2.30880884 |
| 65 | Respiratory failure (HP:0002878) | 2.29794491 |
| 66 | Lethargy (HP:0001254) | 2.26910905 |
| 67 | Neoplasm of the pancreas (HP:0002894) | 2.25908728 |
| 68 | Progressive macrocephaly (HP:0004481) | 2.25031499 |
| 69 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.23373349 |
| 70 | Medial flaring of the eyebrow (HP:0010747) | 2.22220036 |
| 71 | Increased intramyocellular lipid droplets (HP:0012240) | 2.20339624 |
| 72 | Agnosia (HP:0010524) | 2.18582288 |
| 73 | Methylmalonic aciduria (HP:0012120) | 2.17669831 |
| 74 | Type I transferrin isoform profile (HP:0003642) | 2.16240747 |
| 75 | Leukodystrophy (HP:0002415) | 2.14408264 |
| 76 | Acute encephalopathy (HP:0006846) | 2.14153832 |
| 77 | Optic disc pallor (HP:0000543) | 2.13501600 |
| 78 | 11 pairs of ribs (HP:0000878) | 2.13382451 |
| 79 | Cellular immunodeficiency (HP:0005374) | 2.12973263 |
| 80 | Abnormality of midbrain morphology (HP:0002418) | 2.12868073 |
| 81 | Molar tooth sign on MRI (HP:0002419) | 2.12868073 |
| 82 | Abnormal number of incisors (HP:0011064) | 2.12383458 |
| 83 | Abnormal trabecular bone morphology (HP:0100671) | 2.11888418 |
| 84 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.11503928 |
| 85 | Hypoplasia of the radius (HP:0002984) | 2.11477877 |
| 86 | True hermaphroditism (HP:0010459) | 2.10592803 |
| 87 | Neoplasm of the adrenal gland (HP:0100631) | 2.10229124 |
| 88 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 2.09189766 |
| 89 | Volvulus (HP:0002580) | 2.06554807 |
| 90 | Myelodysplasia (HP:0002863) | 2.05904812 |
| 91 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 2.05858869 |
| 92 | Secondary amenorrhea (HP:0000869) | 2.04631571 |
| 93 | Tracheoesophageal fistula (HP:0002575) | 2.02903064 |
| 94 | Premature ovarian failure (HP:0008209) | 2.02063202 |
| 95 | CNS hypomyelination (HP:0003429) | 2.01947512 |
| 96 | Pancreatic cysts (HP:0001737) | 2.01287562 |
| 97 | Abnormal protein glycosylation (HP:0012346) | 1.99415373 |
| 98 | Abnormal glycosylation (HP:0012345) | 1.99415373 |
| 99 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.99415373 |
| 100 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.99415373 |
| 101 | Lipid accumulation in hepatocytes (HP:0006561) | 1.99001576 |
| 102 | Renal cortical cysts (HP:0000803) | 1.98746448 |
| 103 | Short tibia (HP:0005736) | 1.98526278 |
| 104 | Hepatic necrosis (HP:0002605) | 1.98360101 |
| 105 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.98151844 |
| 106 | Abnormality of alanine metabolism (HP:0010916) | 1.98151844 |
| 107 | Hyperalaninemia (HP:0003348) | 1.98151844 |
| 108 | Exercise intolerance (HP:0003546) | 1.97941485 |
| 109 | Facial cleft (HP:0002006) | 1.97878000 |
| 110 | Sloping forehead (HP:0000340) | 1.96313142 |
| 111 | Type 2 muscle fiber atrophy (HP:0003554) | 1.94501306 |
| 112 | Abnormality of the duodenum (HP:0002246) | 1.94473014 |
| 113 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.94108701 |
| 114 | Atresia of the external auditory canal (HP:0000413) | 1.93893958 |
| 115 | Stenosis of the external auditory canal (HP:0000402) | 1.93864381 |
| 116 | Congenital primary aphakia (HP:0007707) | 1.93598061 |
| 117 | CNS demyelination (HP:0007305) | 1.92824229 |
| 118 | Abnormality of glycolysis (HP:0004366) | 1.91827919 |
| 119 | Increased serum pyruvate (HP:0003542) | 1.91827919 |
| 120 | Exertional dyspnea (HP:0002875) | 1.91668138 |
| 121 | Asplenia (HP:0001746) | 1.91586919 |
| 122 | Abnormality of the pons (HP:0007361) | 1.91527533 |
| 123 | Abolished electroretinogram (ERG) (HP:0000550) | 1.90856118 |
| 124 | Embryonal renal neoplasm (HP:0011794) | 1.89818006 |
| 125 | Multiple enchondromatosis (HP:0005701) | 1.89301771 |
| 126 | Muscle fiber atrophy (HP:0100295) | 1.88086259 |
| 127 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 1.86756103 |
| 128 | Gait imbalance (HP:0002141) | 1.86374912 |
| 129 | Ependymoma (HP:0002888) | 1.85685711 |
| 130 | Impulsivity (HP:0100710) | 1.85591939 |
| 131 | Duplicated collecting system (HP:0000081) | 1.85239264 |
| 132 | Intestinal atresia (HP:0011100) | 1.84667440 |
| 133 | Rhabdomyosarcoma (HP:0002859) | 1.84357482 |
| 134 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.84137744 |
| 135 | Abnormality of glycine metabolism (HP:0010895) | 1.84137744 |
| 136 | Reduced antithrombin III activity (HP:0001976) | 1.83067052 |
| 137 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.82119570 |
| 138 | Nephrogenic diabetes insipidus (HP:0009806) | 1.81567862 |
| 139 | Pancreatic fibrosis (HP:0100732) | 1.81480325 |
| 140 | Respiratory difficulties (HP:0002880) | 1.81057447 |
| 141 | Hypoplasia of the pons (HP:0012110) | 1.78971421 |
| 142 | Hyperglycinuria (HP:0003108) | 1.78007639 |
| 143 | Genital tract atresia (HP:0001827) | 1.77998239 |
| 144 | Retinal dysplasia (HP:0007973) | 1.77832265 |
| 145 | Breast carcinoma (HP:0003002) | 1.77709299 |
| 146 | Poor suck (HP:0002033) | 1.72608437 |
| 147 | Bifid tongue (HP:0010297) | 1.71786916 |
| 148 | Congenital, generalized hypertrichosis (HP:0004540) | 1.71441803 |
| 149 | Vaginal atresia (HP:0000148) | 1.70228203 |
| 150 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.68102353 |
| 151 | Glioma (HP:0009733) | 1.68040192 |
| 152 | Megaloblastic anemia (HP:0001889) | 1.67498292 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 5.53835504 |
| 2 | WEE1 | 4.18143145 |
| 3 | STK16 | 3.57791131 |
| 4 | TRIM28 | 3.47855595 |
| 5 | EIF2AK1 | 3.32076825 |
| 6 | SRPK1 | 3.09669848 |
| 7 | CDC7 | 2.96988156 |
| 8 | PLK4 | 2.56551385 |
| 9 | TSSK6 | 2.50241912 |
| 10 | VRK2 | 2.46471678 |
| 11 | VRK1 | 2.44489455 |
| 12 | ACVR1B | 2.42305028 |
| 13 | NME2 | 2.41433101 |
| 14 | WNK3 | 2.38375972 |
| 15 | TLK1 | 2.16596523 |
| 16 | EIF2AK3 | 2.03990490 |
| 17 | NEK1 | 1.99351693 |
| 18 | NEK2 | 1.97274753 |
| 19 | PLK1 | 1.95448803 |
| 20 | NUAK1 | 1.93683046 |
| 21 | DYRK3 | 1.93142538 |
| 22 | EPHA2 | 1.92183798 |
| 23 | TTK | 1.90042138 |
| 24 | TESK2 | 1.82593368 |
| 25 | MAP4K2 | 1.75691359 |
| 26 | BRSK2 | 1.75397448 |
| 27 | MKNK1 | 1.64917181 |
| 28 | PLK3 | 1.63480143 |
| 29 | RPS6KB2 | 1.54181612 |
| 30 | NME1 | 1.53875331 |
| 31 | AURKA | 1.50934412 |
| 32 | BMPR1B | 1.49282412 |
| 33 | PBK | 1.46349682 |
| 34 | AURKB | 1.42796697 |
| 35 | PASK | 1.41456243 |
| 36 | ZAK | 1.41346547 |
| 37 | CDK7 | 1.31430101 |
| 38 | DYRK2 | 1.31300099 |
| 39 | SIK3 | 1.31266893 |
| 40 | ATR | 1.30366047 |
| 41 | PNCK | 1.29322134 |
| 42 | MKNK2 | 1.27228218 |
| 43 | BRSK1 | 1.22736422 |
| 44 | CHEK2 | 1.21953955 |
| 45 | CCNB1 | 1.19319588 |
| 46 | TNIK | 1.09237290 |
| 47 | CSNK1G2 | 1.08558838 |
| 48 | MAP2K7 | 1.02421181 |
| 49 | MAP3K4 | 1.01632117 |
| 50 | PLK2 | 0.99303276 |
| 51 | PIM2 | 0.98862424 |
| 52 | TESK1 | 0.98205290 |
| 53 | MAPKAPK3 | 0.95340692 |
| 54 | BRAF | 0.93684331 |
| 55 | CSNK1A1L | 0.92626561 |
| 56 | CHEK1 | 0.90792375 |
| 57 | PDK2 | 0.89393311 |
| 58 | CDK8 | 0.87401359 |
| 59 | MST4 | 0.87387725 |
| 60 | MAPK13 | 0.84581996 |
| 61 | TGFBR1 | 0.84024174 |
| 62 | PAK4 | 0.83512418 |
| 63 | FRK | 0.82285879 |
| 64 | LIMK1 | 0.81491290 |
| 65 | MINK1 | 0.81459582 |
| 66 | RPS6KA4 | 0.80278309 |
| 67 | CSNK2A1 | 0.78602008 |
| 68 | PRKCI | 0.77234253 |
| 69 | OXSR1 | 0.75698145 |
| 70 | EIF2AK2 | 0.75656175 |
| 71 | CSNK2A2 | 0.75556752 |
| 72 | MUSK | 0.73148181 |
| 73 | IRAK3 | 0.71213926 |
| 74 | MAP3K8 | 0.70410154 |
| 75 | MAP3K11 | 0.69448982 |
| 76 | TAF1 | 0.69411272 |
| 77 | TAOK3 | 0.66842919 |
| 78 | CDK2 | 0.65469033 |
| 79 | ATM | 0.64802426 |
| 80 | MARK1 | 0.64131203 |
| 81 | STK39 | 0.64044553 |
| 82 | GRK1 | 0.63794872 |
| 83 | PAK1 | 0.63067736 |
| 84 | STK38L | 0.61894700 |
| 85 | ARAF | 0.61611095 |
| 86 | CDK4 | 0.59481046 |
| 87 | RPS6KA5 | 0.59062602 |
| 88 | AKT3 | 0.54914375 |
| 89 | YES1 | 0.54455005 |
| 90 | PIK3CA | 0.53735214 |
| 91 | PAK3 | 0.53314606 |
| 92 | STK4 | 0.53215637 |
| 93 | CDK1 | 0.52584964 |
| 94 | ERBB3 | 0.51467328 |
| 95 | SCYL2 | 0.51442013 |
| 96 | ADRBK2 | 0.50982793 |
| 97 | PRKCG | 0.49995425 |
| 98 | DAPK1 | 0.49172459 |
| 99 | INSRR | 0.49090165 |
| 100 | KDR | 0.47297792 |
| 101 | BMPR2 | 0.46321195 |
| 102 | BCR | 0.44084832 |
| 103 | NEK6 | 0.43844006 |
| 104 | PIM1 | 0.43460449 |
| 105 | CDK19 | 0.41936929 |
| 106 | IRAK2 | 0.41899584 |
| 107 | PRKCE | 0.41836892 |
| 108 | TXK | 0.40957585 |
| 109 | IRAK4 | 0.40613011 |
| 110 | CSNK1G3 | 0.39003639 |
| 111 | EPHA4 | 0.37461211 |
| 112 | PINK1 | 0.37400948 |
| 113 | MAPKAPK5 | 0.36202134 |
| 114 | IRAK1 | 0.36134125 |
| 115 | MAP3K12 | 0.34264391 |
| 116 | CSNK1E | 0.33954924 |
| 117 | PDK3 | 0.33887917 |
| 118 | PDK4 | 0.33887917 |
| 119 | ERBB4 | 0.33558534 |
| 120 | CAMK2A | 0.33016629 |
| 121 | CSNK1A1 | 0.30001908 |
| 122 | CDK11A | 0.29189118 |
| 123 | MAP3K9 | 0.29087901 |
| 124 | TAOK2 | 0.28766746 |
| 125 | CDK14 | 0.28358825 |
| 126 | CASK | 0.27902180 |
| 127 | BRD4 | 0.27322006 |
| 128 | ABL2 | 0.26035461 |
| 129 | MELK | 0.25676689 |
| 130 | CDK18 | 0.25374791 |
| 131 | CSNK1G1 | 0.24048432 |
| 132 | CDK15 | 0.23143712 |
| 133 | ILK | 0.21521730 |
| 134 | PRKDC | 0.21180961 |
| 135 | CDK3 | 0.20590886 |
| 136 | STK10 | 0.20283662 |
| 137 | AKT2 | 0.18209818 |
| 138 | BCKDK | 0.16808726 |
| 139 | DYRK1A | 0.15908771 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.53843977 |
| 2 | DNA replication_Homo sapiens_hsa03030 | 4.40885648 |
| 3 | Ribosome_Homo sapiens_hsa03010 | 4.39547907 |
| 4 | Mismatch repair_Homo sapiens_hsa03430 | 3.94941414 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 3.81149864 |
| 6 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.60895116 |
| 7 | * Spliceosome_Homo sapiens_hsa03040 | 3.41264828 |
| 8 | RNA transport_Homo sapiens_hsa03013 | 2.98569997 |
| 9 | Homologous recombination_Homo sapiens_hsa03440 | 2.93325630 |
| 10 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.84741606 |
| 11 | Base excision repair_Homo sapiens_hsa03410 | 2.79305814 |
| 12 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.66551065 |
| 13 | Cell cycle_Homo sapiens_hsa04110 | 2.30912981 |
| 14 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.30088472 |
| 15 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.29332642 |
| 16 | Basal transcription factors_Homo sapiens_hsa03022 | 2.24262137 |
| 17 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.05740124 |
| 18 | RNA degradation_Homo sapiens_hsa03018 | 1.93350830 |
| 19 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.87445404 |
| 20 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.84318379 |
| 21 | Parkinsons disease_Homo sapiens_hsa05012 | 1.84217838 |
| 22 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.77526155 |
| 23 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.71805118 |
| 24 | Huntingtons disease_Homo sapiens_hsa05016 | 1.71344066 |
| 25 | Protein export_Homo sapiens_hsa03060 | 1.68668523 |
| 26 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.65665393 |
| 27 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.59337867 |
| 28 | Purine metabolism_Homo sapiens_hsa00230 | 1.55344049 |
| 29 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.53723861 |
| 30 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.50412911 |
| 31 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.46638246 |
| 32 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.32968722 |
| 33 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.22018858 |
| 34 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.20366486 |
| 35 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.08041068 |
| 36 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.05914368 |
| 37 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.05576424 |
| 38 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.01693684 |
| 39 | Alzheimers disease_Homo sapiens_hsa05010 | 0.99172867 |
| 40 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.98116901 |
| 41 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.86023711 |
| 42 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.83512738 |
| 43 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.82595391 |
| 44 | Peroxisome_Homo sapiens_hsa04146 | 0.74235145 |
| 45 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.72306201 |
| 46 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.71859074 |
| 47 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.68297189 |
| 48 | Nicotine addiction_Homo sapiens_hsa05033 | 0.67852193 |
| 49 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.66152907 |
| 50 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.63464897 |
| 51 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.63118895 |
| 52 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.62823981 |
| 53 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.62061259 |
| 54 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.59086468 |
| 55 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.57989213 |
| 56 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.56718943 |
| 57 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.56090759 |
| 58 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.56086217 |
| 59 | Sulfur relay system_Homo sapiens_hsa04122 | 0.55700121 |
| 60 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.55469540 |
| 61 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.55426627 |
| 62 | Alcoholism_Homo sapiens_hsa05034 | 0.51737860 |
| 63 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.51399086 |
| 64 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.49889507 |
| 65 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.48553465 |
| 66 | HTLV-I infection_Homo sapiens_hsa05166 | 0.47854167 |
| 67 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.46692025 |
| 68 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.42164534 |
| 69 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.41748981 |
| 70 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.41746157 |
| 71 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.40909103 |
| 72 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.40828303 |
| 73 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.40336780 |
| 74 | Metabolic pathways_Homo sapiens_hsa01100 | 0.38849001 |
| 75 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.38828324 |
| 76 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.38535227 |
| 77 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.37791534 |
| 78 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.37632625 |
| 79 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.37523766 |
| 80 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.37115580 |
| 81 | Legionellosis_Homo sapiens_hsa05134 | 0.36151784 |
| 82 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.35947455 |
| 83 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.35670373 |
| 84 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.35535852 |
| 85 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.34797150 |
| 86 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.34780208 |
| 87 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.34264457 |
| 88 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.34097021 |
| 89 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.32720964 |
| 90 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.32648892 |
| 91 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.29091826 |
| 92 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.28442182 |
| 93 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.28409485 |
| 94 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.27066928 |
| 95 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.26909246 |
| 96 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.26623131 |
| 97 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.26191802 |
| 98 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.25451272 |
| 99 | Thyroid cancer_Homo sapiens_hsa05216 | 0.24911713 |
| 100 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.24656051 |
| 101 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.24292352 |
| 102 | Retinol metabolism_Homo sapiens_hsa00830 | 0.24015703 |
| 103 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.23983976 |
| 104 | Olfactory transduction_Homo sapiens_hsa04740 | 0.23516934 |
| 105 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.22779057 |
| 106 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.22113011 |
| 107 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.21973507 |
| 108 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.20602354 |
| 109 | Circadian rhythm_Homo sapiens_hsa04710 | 0.18568490 |
| 110 | Carbon metabolism_Homo sapiens_hsa01200 | 0.18117012 |
| 111 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.17446196 |
| 112 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.15781650 |
| 113 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.14431492 |
| 114 | Colorectal cancer_Homo sapiens_hsa05210 | 0.14018436 |
| 115 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.12785433 |
| 116 | Phototransduction_Homo sapiens_hsa04744 | 0.12669912 |
| 117 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.12340130 |
| 118 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.12135801 |
| 119 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.11874109 |
| 120 | Apoptosis_Homo sapiens_hsa04210 | 0.11628954 |
| 121 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.11173637 |
| 122 | Galactose metabolism_Homo sapiens_hsa00052 | 0.11093548 |
| 123 | Shigellosis_Homo sapiens_hsa05131 | 0.10909248 |
| 124 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.10627058 |
| 125 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.08173314 |
| 126 | Pathways in cancer_Homo sapiens_hsa05200 | 0.08133261 |
| 127 | Tight junction_Homo sapiens_hsa04530 | 0.04122247 |
| 128 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.02214387 |
| 129 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.01638610 |
| 130 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.01461304 |
| 131 | Asthma_Homo sapiens_hsa05310 | 0.00369738 |
| 132 | Other glycan degradation_Homo sapiens_hsa00511 | -0.0306917 |
| 133 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | -0.0297984 |
| 134 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | -0.0262470 |
| 135 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | -0.0099871 |
| 136 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | -0.0025508 |

