BCAS2P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of triglyceride catabolic process (GO:0010896)6.11241850
2negative T cell selection (GO:0043383)5.58485208
3tolerance induction (GO:0002507)5.43748321
4positive T cell selection (GO:0043368)5.26832212
5regulation of regulatory T cell differentiation (GO:0045589)5.26758333
6positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.95846032
7negative thymic T cell selection (GO:0045060)4.94894044
8spermatid nucleus differentiation (GO:0007289)4.73899783
9positive thymic T cell selection (GO:0045059)4.57774915
10rRNA catabolic process (GO:0016075)4.31504115
11regulation of isotype switching to IgG isotypes (GO:0048302)4.29537217
12positive regulation of gamma-delta T cell activation (GO:0046645)4.27571828
13regulation of Golgi to plasma membrane protein transport (GO:0042996)4.14284946
14positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.13088414
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.89731062
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.86859861
17T cell selection (GO:0045058)3.75975212
18thymic T cell selection (GO:0045061)3.67469899
19protoporphyrinogen IX biosynthetic process (GO:0006782)3.65654948
20positive regulation of T cell differentiation in thymus (GO:0033089)3.64149351
21regulation of telomere maintenance via telomerase (GO:0032210)3.62037405
22phospholipid efflux (GO:0033700)3.61005163
23positive regulation of granulocyte differentiation (GO:0030854)3.57428435
24high-density lipoprotein particle remodeling (GO:0034375)3.56864380
25activated T cell proliferation (GO:0050798)3.53595182
26N-acetylglucosamine metabolic process (GO:0006044)3.49089250
27negative regulation of T cell mediated immunity (GO:0002710)3.44119366
28B cell receptor signaling pathway (GO:0050853)3.43801550
29negative regulation of cell killing (GO:0031342)3.39872283
30negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.39872283
31alpha-beta T cell differentiation (GO:0046632)3.36654431
32antigen receptor-mediated signaling pathway (GO:0050851)3.34760906
33antigen processing and presentation of endogenous antigen (GO:0019883)3.33764725
34T cell receptor signaling pathway (GO:0050852)3.33129442
35regulation of alpha-beta T cell proliferation (GO:0046640)3.31238361
36cellular response to interleukin-15 (GO:0071350)3.28821922
37positive regulation of organelle assembly (GO:1902117)3.27367178
38regulation of B cell receptor signaling pathway (GO:0050855)3.26853260
39alpha-beta T cell activation (GO:0046631)3.24026220
40positive regulation of alpha-beta T cell proliferation (GO:0046641)3.20416837
41G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.17566777
42prenylation (GO:0097354)3.15922287
43protein prenylation (GO:0018342)3.15922287
44regulation of gamma-delta T cell differentiation (GO:0045586)3.14325030
45response to interleukin-15 (GO:0070672)3.14165481
46pre-miRNA processing (GO:0031054)3.12693682
47ribosome assembly (GO:0042255)3.12009448
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.11361271
49mast cell activation (GO:0045576)3.08930784
50interferon-gamma production (GO:0032609)3.07616774
51regulation of interleukin-2 biosynthetic process (GO:0045076)3.03574239
52reverse cholesterol transport (GO:0043691)3.02213007
53positive regulation of B cell differentiation (GO:0045579)3.01599256
54regulation of gamma-delta T cell activation (GO:0046643)3.00969267
55purinergic nucleotide receptor signaling pathway (GO:0035590)2.99626879
56T cell migration (GO:0072678)2.99475061
57plasma lipoprotein particle assembly (GO:0034377)2.97506012
58RNA destabilization (GO:0050779)2.97083868
59negative regulation of lipid catabolic process (GO:0050995)2.91428493
60histone H4-K8 acetylation (GO:0043982)2.90512289
61histone H4-K5 acetylation (GO:0043981)2.90512289
62regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.88566081
63regulation of interleukin-12 biosynthetic process (GO:0045075)2.87810256
64axoneme assembly (GO:0035082)2.86716796
65growth hormone receptor signaling pathway (GO:0060396)2.84320783
66atrial cardiac muscle cell action potential (GO:0086014)2.82951630
67RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.82076012
68T cell differentiation (GO:0030217)2.77701368
69positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.75763412
70regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.75763412
71regulation of telomere maintenance (GO:0032204)2.75658910
72cytidine metabolic process (GO:0046087)2.74767472
73cytidine catabolic process (GO:0006216)2.74767472
74cytidine deamination (GO:0009972)2.74767472
75phosphatidylethanolamine metabolic process (GO:0046337)2.73310166
76DNA deamination (GO:0045006)2.73220704
77positive regulation of tolerance induction (GO:0002645)2.73130022
78water-soluble vitamin biosynthetic process (GO:0042364)2.72192240
79regulation of T cell receptor signaling pathway (GO:0050856)2.71098339
80indolalkylamine metabolic process (GO:0006586)2.70973737
81positive regulation of interleukin-4 production (GO:0032753)2.70275747
82regulation of cilium movement (GO:0003352)2.70066355
83protein ADP-ribosylation (GO:0006471)2.68316920
84negative regulation of stress fiber assembly (GO:0051497)2.67373122
85positive regulation of CREB transcription factor activity (GO:0032793)2.67218334
86regulation of T cell tolerance induction (GO:0002664)2.65339481
87protoporphyrinogen IX metabolic process (GO:0046501)2.64597648
88positive regulation of mRNA catabolic process (GO:0061014)2.64567323
89negative regulation of T cell apoptotic process (GO:0070233)2.63964452
90cellular response to interferon-beta (GO:0035458)2.63924576
91phosphatidylethanolamine biosynthetic process (GO:0006646)2.62182410
92regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.61998377
93positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.61998377
94natural killer cell activation involved in immune response (GO:0002323)2.61528692
95protein-lipid complex assembly (GO:0065005)2.61007817
96regulation of T cell mediated cytotoxicity (GO:0001914)2.60006177
97pyrimidine ribonucleoside catabolic process (GO:0046133)2.59107069
98phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.59062827
99positive regulation of natural killer cell differentiation (GO:0032825)2.58565966
100establishment of protein localization to Golgi (GO:0072600)2.56862200

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.56788566
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.14296652
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.47707097
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.47457566
5RUNX_20019798_ChIP-Seq_JUKART_Human3.42934897
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.16311404
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.16176828
8VDR_22108803_ChIP-Seq_LS180_Human2.93103099
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.83819317
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.69164925
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.35379310
12MYB_26560356_Chip-Seq_TH2_Human2.34889654
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.24979932
14ZNF274_21170338_ChIP-Seq_K562_Hela2.14143783
15GATA3_26560356_Chip-Seq_TH2_Human2.06709655
16MYB_26560356_Chip-Seq_TH1_Human1.97983631
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.96507761
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96283135
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89498342
20GATA3_27048872_Chip-Seq_THYMUS_Human1.84785584
21TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.71047923
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.68220622
23RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.67333440
24VDR_23849224_ChIP-Seq_CD4+_Human1.66331744
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64811589
26EGR1_23403033_ChIP-Seq_LIVER_Mouse1.61560720
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57011187
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.55814465
29UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54491591
30GABP_17652178_ChIP-ChIP_JURKAT_Human1.53797008
31PRDM14_20953172_ChIP-Seq_ESCs_Human1.48374661
32IRF8_21731497_ChIP-ChIP_J774_Mouse1.43355945
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.42375556
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42354465
35MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.40497847
36IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37095060
37CBP_20019798_ChIP-Seq_JUKART_Human1.37095060
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34134011
39ELK1_19687146_ChIP-ChIP_HELA_Human1.30807207
40TAF15_26573619_Chip-Seq_HEK293_Human1.29477824
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.26201403
42SOX2_19829295_ChIP-Seq_ESCs_Human1.25901973
43NANOG_19829295_ChIP-Seq_ESCs_Human1.25901973
44IGF1R_20145208_ChIP-Seq_DFB_Human1.25291954
45CDX2_22108803_ChIP-Seq_LS180_Human1.24701306
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22672963
47SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22665529
48CIITA_25753668_ChIP-Seq_RAJI_Human1.21543557
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18365647
50TP53_22573176_ChIP-Seq_HFKS_Human1.18276039
51LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18144284
52SMRT_27268052_Chip-Seq_Bcells_Human1.18021452
53GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17468486
54GATA3_26560356_Chip-Seq_TH1_Human1.16756255
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.14525397
56HTT_18923047_ChIP-ChIP_STHdh_Human1.12672557
57PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12407687
58P300_19829295_ChIP-Seq_ESCs_Human1.11598791
59TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11468121
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11116946
61RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10925874
62TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.10881216
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09785144
64IRF8_27001747_Chip-Seq_BMDM_Mouse1.09167696
65FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08195561
66STAT3_23295773_ChIP-Seq_U87_Human1.06586024
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.05711642
68P53_22387025_ChIP-Seq_ESCs_Mouse1.04880038
69RXR_22108803_ChIP-Seq_LS180_Human1.03589688
70HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02338015
71EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02302771
72NANOG_20526341_ChIP-Seq_ESCs_Human1.01805286
73E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.01184753
74FOXP3_21729870_ChIP-Seq_TREG_Human1.00926420
75SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98093065
76FUS_26573619_Chip-Seq_HEK293_Human0.97756884
77FOXA1_25329375_ChIP-Seq_VCAP_Human0.97293939
78FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97293939
79NANOG_18555785_Chip-Seq_ESCs_Mouse0.97169171
80BCAT_22108803_ChIP-Seq_LS180_Human0.96738201
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96364861
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95914508
83GBX2_23144817_ChIP-Seq_PC3_Human0.93467217
84SCL_19346495_ChIP-Seq_HPC-7_Human0.92815964
85FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91745136
86FOXH1_21741376_ChIP-Seq_EPCs_Human0.91449756
87IRF1_19129219_ChIP-ChIP_H3396_Human0.91363608
88SPI1_23547873_ChIP-Seq_NB4_Human0.91347265
89NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91080275
90SMAD4_21799915_ChIP-Seq_A2780_Human0.90714813
91EWS_26573619_Chip-Seq_HEK293_Human0.90287531
92GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.89890987
93TCF4_22108803_ChIP-Seq_LS180_Human0.89783986
94TCF4_23295773_ChIP-Seq_U87_Human0.88868610
95CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88745026
96SMAD4_21741376_ChIP-Seq_EPCs_Human0.88727590
97PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88556385
98MYC_18940864_ChIP-ChIP_HL60_Human0.88458461
99E2F1_18555785_Chip-Seq_ESCs_Mouse0.88152116
100AR_25329375_ChIP-Seq_VCAP_Human0.87834401

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology3.57746728
2MP0009840_abnormal_foam_cell3.19404864
3MP0005671_abnormal_response_to2.91017654
4MP0002876_abnormal_thyroid_physiology2.59300527
5MP0004142_abnormal_muscle_tone2.53937136
6MP0009379_abnormal_foot_pigmentation2.45043667
7MP0001800_abnormal_humoral_immune2.44953745
8MP0002138_abnormal_hepatobiliary_system2.42760816
9MP0001873_stomach_inflammation2.25130451
10MP0003787_abnormal_imprinting2.22702925
11MP0009333_abnormal_splenocyte_physiolog2.22483490
12MP0004185_abnormal_adipocyte_glucose2.19862622
13MP0005310_abnormal_salivary_gland2.16622882
14MP0005000_abnormal_immune_tolerance2.03994807
15MP0001835_abnormal_antigen_presentation1.98591651
16MP0002723_abnormal_immune_serum1.97746135
17MP0005551_abnormal_eye_electrophysiolog1.97159174
18MP0002837_dystrophic_cardiac_calcinosis1.91349343
19MP0003436_decreased_susceptibility_to1.89228359
20MP0005464_abnormal_platelet_physiology1.88887987
21MP0002420_abnormal_adaptive_immunity1.88104296
22MP0002277_abnormal_respiratory_mucosa1.87213790
23MP0000703_abnormal_thymus_morphology1.85559606
24MP0003724_increased_susceptibility_to1.83789994
25MP0001819_abnormal_immune_cell1.83497270
26MP0002148_abnormal_hypersensitivity_rea1.79895102
27MP0005360_urolithiasis1.76975454
28MP0001790_abnormal_immune_system1.76155593
29MP0005387_immune_system_phenotype1.76155593
30MP0004742_abnormal_vestibular_system1.73641486
31MP0001851_eye_inflammation1.72256571
32MP0002452_abnormal_antigen_presenting1.71229744
33MP0002398_abnormal_bone_marrow1.70778537
34MP0003567_abnormal_fetal_cardiomyocyte1.65088193
35MP0000716_abnormal_immune_system1.62167113
36MP0008877_abnormal_DNA_methylation1.59546919
37MP0002166_altered_tumor_susceptibility1.59050486
38MP0000689_abnormal_spleen_morphology1.58578318
39MP0002102_abnormal_ear_morphology1.53601218
40MP0001986_abnormal_taste_sensitivity1.52638230
41MP0001984_abnormal_olfaction1.49227226
42MP0010155_abnormal_intestine_physiology1.49011756
43MP0003866_abnormal_defecation1.42756974
44MP0006082_CNS_inflammation1.40101313
45MP0002405_respiratory_system_inflammati1.36689876
46MP0006072_abnormal_retinal_apoptosis1.34993225
47MP0002722_abnormal_immune_system1.31502735
48MP0004130_abnormal_muscle_cell1.29511035
49MP0001968_abnormal_touch/_nociception1.29386327
50MP0000685_abnormal_immune_system1.27751720
51MP0002822_catalepsy1.21363336
52MP0001919_abnormal_reproductive_system1.20289968
53MP0004381_abnormal_hair_follicle1.20172385
54MP0009785_altered_susceptibility_to1.18340509
55MP0002933_joint_inflammation1.17748031
56MP0002429_abnormal_blood_cell1.16123999
57MP0005025_abnormal_response_to1.13050077
58MP0002006_tumorigenesis1.11646617
59MP0001188_hyperpigmentation1.08860664
60MP0004885_abnormal_endolymph1.08569081
61MP0005646_abnormal_pituitary_gland1.08527920
62MP0002419_abnormal_innate_immunity1.07334712
63MP0004145_abnormal_muscle_electrophysio1.03384255
64MP0010329_abnormal_lipoprotein_level1.01597224
65MP0002396_abnormal_hematopoietic_system1.00328320
66MP0008058_abnormal_DNA_repair0.99598054
67MP0000537_abnormal_urethra_morphology0.99539246
68MP0005174_abnormal_tail_pigmentation0.98859736
69MP0008775_abnormal_heart_ventricle0.98805446
70MP0001661_extended_life_span0.98164526
71MP0004883_abnormal_blood_vessel0.97928317
72MP0000372_irregular_coat_pigmentation0.97903790
73MP0009780_abnormal_chondrocyte_physiolo0.96961185
74MP0001845_abnormal_inflammatory_respons0.96736862
75MP0001663_abnormal_digestive_system0.95309087
76MP0005187_abnormal_penis_morphology0.95264058
77MP0005389_reproductive_system_phenotype0.94572735
78MP0006054_spinal_hemorrhage0.94259948
79MP0002254_reproductive_system_inflammat0.92528702
80MP0005636_abnormal_mineral_homeostasis0.92075863
81MP0005367_renal/urinary_system_phenotyp0.90162463
82MP0000516_abnormal_urinary_system0.90162463
83MP0003786_premature_aging0.86678090
84MP0005253_abnormal_eye_physiology0.86582992
85MP0001765_abnormal_ion_homeostasis0.85692765
86MP0008569_lethality_at_weaning0.80668441
87MP0005666_abnormal_adipose_tissue0.79770202
88MP0000465_gastrointestinal_hemorrhage0.79531578
89MP0005220_abnormal_exocrine_pancreas0.77550760
90MP0000490_abnormal_crypts_of0.76701655
91MP0001533_abnormal_skeleton_physiology0.76455832
92MP0002009_preneoplasia0.75839609
93MP0002693_abnormal_pancreas_physiology0.73626297
94MP0000249_abnormal_blood_vessel0.72354173
95MP0001915_intracranial_hemorrhage0.72054871
96MP0002734_abnormal_mechanical_nocicepti0.71048959
97MP0005410_abnormal_fertilization0.70320005
98MP0000427_abnormal_hair_cycle0.70299615
99MP0008995_early_reproductive_senescence0.69460428
100MP0008469_abnormal_protein_level0.69455042

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)4.42429827
2Thyroiditis (HP:0100646)4.17498236
3Abnormality of T cell number (HP:0011839)4.16393361
4Stomach cancer (HP:0012126)3.78650948
5Abnormality of the nasal septum (HP:0000419)3.72731298
6Genetic anticipation (HP:0003743)3.69094965
7Autoimmune hemolytic anemia (HP:0001890)3.65401079
8Severe combined immunodeficiency (HP:0004430)3.58226151
9Stomatitis (HP:0010280)3.48380598
10IgG deficiency (HP:0004315)3.34847773
11Renal cortical cysts (HP:0000803)3.03874517
12Congenital stationary night blindness (HP:0007642)3.00300123
13Abnormality of T cells (HP:0002843)2.93233952
14Metaphyseal dysplasia (HP:0100255)2.92693024
15Cutaneous melanoma (HP:0012056)2.91687189
16Pancreatic cysts (HP:0001737)2.82512809
17Panhypogammaglobulinemia (HP:0003139)2.77519134
18Abnormal rod and cone electroretinograms (HP:0008323)2.76895952
19Abnormality of the renal cortex (HP:0011035)2.74950248
20Abnormality of the prostate (HP:0008775)2.73427585
21Hypobetalipoproteinemia (HP:0003563)2.72352370
22Constricted visual fields (HP:0001133)2.70408112
23Absent rod-and cone-mediated responses on ERG (HP:0007688)2.69405948
24Degeneration of the lateral corticospinal tracts (HP:0002314)2.61935600
25Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.61935600
26Choroideremia (HP:0001139)2.58953906
27Combined immunodeficiency (HP:0005387)2.58460250
28Abnormality of eosinophils (HP:0001879)2.53580089
29Aplastic anemia (HP:0001915)2.53204069
30Eosinophilia (HP:0001880)2.50028951
31Adactyly (HP:0009776)2.49123054
32Abnormality of B cell number (HP:0010975)2.43726208
33Large for gestational age (HP:0001520)2.40089777
34Elevated erythrocyte sedimentation rate (HP:0003565)2.34308040
35B lymphocytopenia (HP:0010976)2.33262209
36Recurrent viral infections (HP:0004429)2.27618031
37Prostate neoplasm (HP:0100787)2.22983912
38Bile duct proliferation (HP:0001408)2.22322711
39Abnormal biliary tract physiology (HP:0012439)2.22322711
40Hyperlipoproteinemia (HP:0010980)2.21403685
41Congenital, generalized hypertrichosis (HP:0004540)2.16349090
42Oral leukoplakia (HP:0002745)2.15748042
43Hematochezia (HP:0002573)2.13985530
443-Methylglutaconic aciduria (HP:0003535)2.13420890
45Abnormal delayed hypersensitivity skin test (HP:0002963)2.12512600
46Encephalitis (HP:0002383)2.10841616
47IgM deficiency (HP:0002850)2.10542096
48Pustule (HP:0200039)2.10336549
49Acute lymphatic leukemia (HP:0006721)2.10238483
50Autoimmune thrombocytopenia (HP:0001973)2.08967307
51Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.08323546
52Abnormality of the phalanges of the 2nd finger (HP:0009541)2.08146566
53Abnormality of T cell physiology (HP:0011840)2.07950720
54Rhinitis (HP:0012384)2.06977828
55Bilateral microphthalmos (HP:0007633)2.06597533
56Nephronophthisis (HP:0000090)2.06109316
57Increased hepatocellular lipid droplets (HP:0006565)2.05806994
58Alveolar cell carcinoma (HP:0006519)2.03377162
59Recurrent fungal infections (HP:0002841)2.03249891
60Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.02426810
61Neoplasm of the tracheobronchial system (HP:0100552)2.02341638
62Widely spaced teeth (HP:0000687)2.00138680
63Medial flaring of the eyebrow (HP:0010747)1.99061069
64Lipid accumulation in hepatocytes (HP:0006561)1.97469460
65Recurrent cutaneous fungal infections (HP:0011370)1.95368669
66Chronic mucocutaneous candidiasis (HP:0002728)1.95368669
67Pancytopenia (HP:0001876)1.94001288
68Ketosis (HP:0001946)1.91735834
69Granulocytopenia (HP:0001913)1.91341540
70Abnormality of the proximal phalanges of the hand (HP:0009834)1.89260492
71Abnormality of the renal medulla (HP:0100957)1.88613747
72Leukocytosis (HP:0001974)1.88488754
73Ureteral stenosis (HP:0000071)1.87302701
74Ureteral obstruction (HP:0006000)1.86378896
75Pancreatic fibrosis (HP:0100732)1.84877284
76Abnormality of midbrain morphology (HP:0002418)1.83841427
77Molar tooth sign on MRI (HP:0002419)1.83841427
78Pulmonary infiltrates (HP:0002113)1.82107505
79Gaze-evoked nystagmus (HP:0000640)1.82083144
80Hypochromic microcytic anemia (HP:0004840)1.82026923
81Renal Fanconi syndrome (HP:0001994)1.81835931
82Hypoproteinemia (HP:0003075)1.80523268
83Abnormality of the phalanges of the 5th finger (HP:0004213)1.80223041
84Hypoplasia of the thymus (HP:0000778)1.78122317
85Pendular nystagmus (HP:0012043)1.78035311
86Joint swelling (HP:0001386)1.75427109
87Tetany (HP:0001281)1.73016353
88Basal cell carcinoma (HP:0002671)1.71937311
89Agitation (HP:0000713)1.71838877
90Disinhibition (HP:0000734)1.71699626
91Methylmalonic acidemia (HP:0002912)1.70575697
92Abnormality of the corticospinal tract (HP:0002492)1.69588026
93Attenuation of retinal blood vessels (HP:0007843)1.69357609
94Abnormal albumin level (HP:0012116)1.69348866
95Hypoalbuminemia (HP:0003073)1.69348866
96Abnormality of male internal genitalia (HP:0000022)1.67879768
97True hermaphroditism (HP:0010459)1.67704201
98Asplenia (HP:0001746)1.67643325
99Keratoconjunctivitis (HP:0001096)1.67250700
100Symphalangism affecting the phalanges of the hand (HP:0009773)1.66514816

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.47207067
2FRK4.07962795
3TEC4.01012676
4ITK3.94444208
5WNK33.72294904
6PIK3CG3.03536175
7TAOK32.96200509
8MST42.55778126
9ACVR1B2.48593238
10MAP4K12.40095536
11BTK2.37703562
12MUSK2.21215524
13EIF2AK32.17259014
14ZAK1.88092682
15PIK3CA1.84646834
16TESK21.68407653
17TLK11.54061170
18GRK61.50497224
19NTRK31.45627064
20FGFR21.44799014
21NUAK11.44371791
22MAP3K21.37213379
23KSR21.29819846
24SYK1.29159806
25LCK1.27734984
26KSR11.23647327
27PLK21.22129008
28CAMKK21.21491331
29HCK1.20580128
30TNIK1.17812466
31GRK11.17016321
32STK161.13440608
33ZAP701.10763520
34FES1.09661602
35RIPK41.08990012
36NLK1.07296330
37RAF11.05679514
38PHKG21.03266669
39PHKG11.03266669
40TYK21.01269129
41BRD40.97373724
42ADRBK20.94821171
43IKBKE0.93980368
44EIF2AK20.86947196
45CDK30.84440504
46FGFR30.83607660
47CLK10.79932117
48BMPR1B0.78868138
49WNK40.74955523
50MARK30.72955899
51MAP2K60.72913024
52RPS6KA50.71131859
53MAP4K20.70817482
54MAPK70.67113356
55MAPK130.66707446
56LYN0.66432791
57PIM10.65638876
58IKBKB0.65500023
59STK30.65441004
60GRK70.64442262
61GRK50.64350871
62JAK10.64093400
63JAK30.63630150
64ERBB20.60544173
65IRAK20.60363480
66CSK0.59465276
67MKNK20.55425252
68STK100.53923431
69STK390.53415917
70PRKCQ0.52109549
71ERBB30.51892116
72TRPM70.51455912
73KIT0.50378566
74KDR0.47854102
75STK40.46092956
76OXSR10.45062416
77TNK20.42071171
78HIPK20.39785886
79BCKDK0.37168443
80IGF1R0.37067994
81PINK10.36827692
82BCR0.36776588
83SGK10.36184781
84PASK0.35931519
85CHUK0.34771292
86PRKCI0.34698312
87MAPK120.34418981
88MAP3K90.34281779
89JAK20.33917041
90ABL10.33084731
91CAMKK10.31762918
92NME10.28894491
93DYRK1A0.27856598
94RET0.27428912
95PAK30.26422759
96SCYL20.24616288
97INSRR0.24130712
98ADRBK10.23654861
99NTRK20.22473981
100RPS6KA60.20587429

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.02762642
2T cell receptor signaling pathway_Homo sapiens_hsa046603.15314448
3Autoimmune thyroid disease_Homo sapiens_hsa053202.84477837
4Allograft rejection_Homo sapiens_hsa053302.78406454
5Graft-versus-host disease_Homo sapiens_hsa053322.76179123
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.55184707
7Vitamin digestion and absorption_Homo sapiens_hsa049772.26313403
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.07541865
9Type I diabetes mellitus_Homo sapiens_hsa049401.97149806
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.89159634
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.85385784
12Linoleic acid metabolism_Homo sapiens_hsa005911.82239342
13Asthma_Homo sapiens_hsa053101.70362329
14Hematopoietic cell lineage_Homo sapiens_hsa046401.63164890
15Carbohydrate digestion and absorption_Homo sapiens_hsa049731.53194735
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.50299217
17Homologous recombination_Homo sapiens_hsa034401.48910505
18Ether lipid metabolism_Homo sapiens_hsa005651.47084540
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.45366957
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.39136602
21Regulation of autophagy_Homo sapiens_hsa041401.35425339
22Measles_Homo sapiens_hsa051621.26797551
23Antigen processing and presentation_Homo sapiens_hsa046121.26313195
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.25943862
25Nitrogen metabolism_Homo sapiens_hsa009101.23171431
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22477884
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22310699
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19437252
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.14119968
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.09259030
31Osteoclast differentiation_Homo sapiens_hsa043801.08547052
32Oxidative phosphorylation_Homo sapiens_hsa001901.08294066
33RNA degradation_Homo sapiens_hsa030181.07045708
34B cell receptor signaling pathway_Homo sapiens_hsa046621.03790785
35Morphine addiction_Homo sapiens_hsa050321.03410139
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.03159614
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01063155
38Leishmaniasis_Homo sapiens_hsa051400.98015859
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.96567064
40Staphylococcus aureus infection_Homo sapiens_hsa051500.94917608
41Rheumatoid arthritis_Homo sapiens_hsa053230.94707622
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94590289
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93141828
44Phototransduction_Homo sapiens_hsa047440.91215766
45Glycerophospholipid metabolism_Homo sapiens_hsa005640.90336610
46Platelet activation_Homo sapiens_hsa046110.86843595
47Tryptophan metabolism_Homo sapiens_hsa003800.86584567
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.86447674
49Herpes simplex infection_Homo sapiens_hsa051680.84974715
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83832362
51Parkinsons disease_Homo sapiens_hsa050120.83344315
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.81294053
53Mineral absorption_Homo sapiens_hsa049780.80607705
54p53 signaling pathway_Homo sapiens_hsa041150.80603070
55Chemical carcinogenesis_Homo sapiens_hsa052040.80281359
56Type II diabetes mellitus_Homo sapiens_hsa049300.79583297
57Alzheimers disease_Homo sapiens_hsa050100.74922366
58Fat digestion and absorption_Homo sapiens_hsa049750.74847762
59Glycerolipid metabolism_Homo sapiens_hsa005610.74595540
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74533381
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74089340
62Selenocompound metabolism_Homo sapiens_hsa004500.72617098
63Serotonergic synapse_Homo sapiens_hsa047260.71660924
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69863894
65Inositol phosphate metabolism_Homo sapiens_hsa005620.69488415
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68687384
67Arachidonic acid metabolism_Homo sapiens_hsa005900.68249879
68Renin secretion_Homo sapiens_hsa049240.64406474
69African trypanosomiasis_Homo sapiens_hsa051430.63422661
70TNF signaling pathway_Homo sapiens_hsa046680.61507268
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61058542
72Ribosome_Homo sapiens_hsa030100.60834102
73Taste transduction_Homo sapiens_hsa047420.60349933
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58754675
75Prolactin signaling pathway_Homo sapiens_hsa049170.58590118
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57705645
77Chemokine signaling pathway_Homo sapiens_hsa040620.55000861
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54810550
79Circadian rhythm_Homo sapiens_hsa047100.54487986
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51385655
81Dorso-ventral axis formation_Homo sapiens_hsa043200.50262278
82Viral myocarditis_Homo sapiens_hsa054160.49806074
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47973708
84Long-term depression_Homo sapiens_hsa047300.43987833
85Cholinergic synapse_Homo sapiens_hsa047250.42906069
86Nicotine addiction_Homo sapiens_hsa050330.42823241
87Proteasome_Homo sapiens_hsa030500.42303324
88Calcium signaling pathway_Homo sapiens_hsa040200.41531731
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40862297
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40841732
91Systemic lupus erythematosus_Homo sapiens_hsa053220.40818803
92Fanconi anemia pathway_Homo sapiens_hsa034600.39319198
93Insulin resistance_Homo sapiens_hsa049310.38611987
94Toxoplasmosis_Homo sapiens_hsa051450.38340035
95Circadian entrainment_Homo sapiens_hsa047130.38215671
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38199153
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37832779
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36453864
99GnRH signaling pathway_Homo sapiens_hsa049120.35871153
100Huntingtons disease_Homo sapiens_hsa050160.35864265

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