BCAS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hepatocyte apoptotic process (GO:0097284)7.80410657
2regulation of branching involved in prostate gland morphogenesis (GO:0060687)6.50903972
3ear development (GO:0043583)6.49955981
4striated muscle atrophy (GO:0014891)6.31122347
5positive regulation of keratinocyte differentiation (GO:0045618)6.25600037
6vagina development (GO:0060068)6.21732227
7regulation of cell proliferation involved in kidney development (GO:1901722)5.85443340
8skeletal muscle adaptation (GO:0043501)5.65733657
9muscle atrophy (GO:0014889)5.40648322
10piRNA metabolic process (GO:0034587)5.36359688
11mesonephros development (GO:0001823)5.16962754
12norepinephrine metabolic process (GO:0042415)5.16070449
13intestinal epithelial cell development (GO:0060576)5.15913682
14negative regulation of organelle assembly (GO:1902116)5.10393368
15female genitalia development (GO:0030540)4.93351838
16cardiac right ventricle morphogenesis (GO:0003215)4.74004781
17embryonic camera-type eye morphogenesis (GO:0048596)4.70142037
18uterus development (GO:0060065)4.66945145
19regulation of centriole replication (GO:0046599)4.48871755
20CDP-diacylglycerol metabolic process (GO:0046341)4.48087518
21TOR signaling (GO:0031929)4.46783420
22response to food (GO:0032094)4.42702304
23negative regulation of cell size (GO:0045792)4.41602405
24adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.37392016
25DNA methylation involved in gamete generation (GO:0043046)4.31742982
26synaptonemal complex assembly (GO:0007130)4.30347000
27embryonic eye morphogenesis (GO:0048048)4.18717640
28regulation of meiosis I (GO:0060631)4.09203460
29positive regulation of epidermal cell differentiation (GO:0045606)4.08594069
30regulation of interleukin-13 production (GO:0032656)4.08516547
31response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.08074051
32regulation of fatty acid beta-oxidation (GO:0031998)4.04879824
33NADH metabolic process (GO:0006734)4.04682694
34nitric oxide biosynthetic process (GO:0006809)4.04295879
35synaptonemal complex organization (GO:0070193)3.98476815
36negative regulation of kidney development (GO:0090185)3.95202068
37peptidyl-arginine omega-N-methylation (GO:0035247)3.93087994
38post-embryonic morphogenesis (GO:0009886)3.89616541
39CDP-diacylglycerol biosynthetic process (GO:0016024)3.82981256
40outflow tract septum morphogenesis (GO:0003148)3.76479106
41autophagic vacuole assembly (GO:0000045)3.75478768
42regulation of histone H3-K27 methylation (GO:0061085)3.74067936
43negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.72981945
44purine nucleobase biosynthetic process (GO:0009113)3.72180628
45insulin-like growth factor receptor signaling pathway (GO:0048009)3.71576675
46meiosis I (GO:0007127)3.63091955
47intracellular estrogen receptor signaling pathway (GO:0030520)3.59785689
48vitamin transmembrane transport (GO:0035461)3.56402440
49regulation of interleukin-5 production (GO:0032674)3.56270981
50male meiosis I (GO:0007141)3.53973901
51cell differentiation involved in embryonic placenta development (GO:0060706)3.53020479
52amyloid precursor protein catabolic process (GO:0042987)3.49989464
53cilium or flagellum-dependent cell motility (GO:0001539)3.47981597
54amino acid salvage (GO:0043102)3.47654759
55L-methionine salvage (GO:0071267)3.47654759
56L-methionine biosynthetic process (GO:0071265)3.47654759
57peptidyl-arginine methylation (GO:0018216)3.38423646
58peptidyl-arginine N-methylation (GO:0035246)3.38423646
59positive regulation of synapse maturation (GO:0090129)3.36194258
60negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.35195724
61negative regulation of macroautophagy (GO:0016242)3.35003785
62* regulation of establishment or maintenance of cell polarity (GO:0032878)3.31022937
63interferon-gamma secretion (GO:0072643)3.27725039
64negative regulation of sodium ion transport (GO:0010766)3.26933279
65regulation of uterine smooth muscle contraction (GO:0070472)3.26717054
66lung-associated mesenchyme development (GO:0060484)3.26077825
67regulation of water loss via skin (GO:0033561)3.25861241
68male meiosis (GO:0007140)3.24573250
69positive regulation of fatty acid beta-oxidation (GO:0032000)3.23501043
70phosphatidylinositol 3-kinase signaling (GO:0014065)3.21428181
71regulation of keratinocyte differentiation (GO:0045616)3.20736736
72motile cilium assembly (GO:0044458)3.20125806
73rRNA modification (GO:0000154)3.20069570
74regulation of short-term neuronal synaptic plasticity (GO:0048172)3.15207327
75embryonic retina morphogenesis in camera-type eye (GO:0060059)3.13543948
76phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.12998062
77face development (GO:0060324)3.12779149
78cilium movement (GO:0003341)3.12175183
79axonemal dynein complex assembly (GO:0070286)3.07849498
80regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.06762539
81negative regulation of embryonic development (GO:0045992)3.06382141
82pantothenate metabolic process (GO:0015939)3.03608184
83ribosome assembly (GO:0042255)3.02563449
84ventricular system development (GO:0021591)3.01049562
85serine family amino acid catabolic process (GO:0009071)3.00704276
86positive regulation of hormone metabolic process (GO:0032352)2.96839555
87oocyte maturation (GO:0001556)2.94928078
88branching involved in mammary gland duct morphogenesis (GO:0060444)2.93941908
89nucleobase biosynthetic process (GO:0046112)2.93513588
90glucose 6-phosphate metabolic process (GO:0051156)2.93430154
91prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.92998897
92regulation of acyl-CoA biosynthetic process (GO:0050812)2.92442495
93cellular response to interferon-alpha (GO:0035457)2.91231201
94methionine biosynthetic process (GO:0009086)2.91214270
95meiotic nuclear division (GO:0007126)2.90559324
96histone arginine methylation (GO:0034969)2.89874745
97epithelial cell maturation (GO:0002070)2.87832532
98L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.85212134
99C4-dicarboxylate transport (GO:0015740)2.84461228
100regulation of DNA methylation (GO:0044030)2.84284971
101receptor recycling (GO:0001881)2.83604834
102neuronal action potential propagation (GO:0019227)2.82366694
103response to insecticide (GO:0017085)2.80811994
104sympathetic nervous system development (GO:0048485)2.80480833
105mitotic metaphase plate congression (GO:0007080)2.80293051
1067-methylguanosine mRNA capping (GO:0006370)2.79752768
107phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.79434368
108regulation of mitochondrial translation (GO:0070129)2.78992633
109regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.78779678
110S-adenosylmethionine metabolic process (GO:0046500)2.77875781
111biotin metabolic process (GO:0006768)2.77321233
112establishment of protein localization to mitochondrial membrane (GO:0090151)2.75486238
113sulfur amino acid biosynthetic process (GO:0000097)2.75122212
114chromosome organization involved in meiosis (GO:0070192)2.74192077
115positive regulation of embryonic development (GO:0040019)2.73664167
116aspartate family amino acid biosynthetic process (GO:0009067)2.72997559
117positive regulation of fatty acid oxidation (GO:0046321)2.72744022
118mitochondrion degradation (GO:0000422)2.72007082
119fructose metabolic process (GO:0006000)2.71198092
120response to water (GO:0009415)2.69067801
121positive regulation of cellular amine metabolic process (GO:0033240)2.68813948
122* regulation of establishment of cell polarity (GO:2000114)2.68610305
123methionine metabolic process (GO:0006555)2.68128773
124rRNA methylation (GO:0031167)2.68058698
125regulation of cofactor metabolic process (GO:0051193)2.68032596
126regulation of coenzyme metabolic process (GO:0051196)2.68032596
127regulation of synaptic vesicle transport (GO:1902803)2.66335950
128ribosome biogenesis (GO:0042254)2.66203372
1297-methylguanosine RNA capping (GO:0009452)2.64728044
130RNA capping (GO:0036260)2.64728044
131regulation of centrosome duplication (GO:0010824)2.64645428
132SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)2.64523867
133regulation of mammary gland epithelial cell proliferation (GO:0033599)2.64509881
134establishment of mitochondrion localization (GO:0051654)2.64395070
135neuromuscular process controlling posture (GO:0050884)2.62922881
136labyrinthine layer development (GO:0060711)2.62031443
137peptidyl-threonine dephosphorylation (GO:0035970)2.61781904
138iron coordination entity transport (GO:1901678)2.61140469
139trivalent inorganic anion homeostasis (GO:0072506)2.60957904
140phosphate ion homeostasis (GO:0055062)2.60957904
141peptidyl-lysine dimethylation (GO:0018027)2.60565455
142folic acid metabolic process (GO:0046655)2.60154541
143glycine metabolic process (GO:0006544)2.57428552
144glutamate secretion (GO:0014047)2.57156250
145positive regulation of glycogen biosynthetic process (GO:0045725)2.57080403
146cell proliferation involved in metanephros development (GO:0072203)2.56819136
147cofactor transport (GO:0051181)2.54915064
148positive regulation of autophagy (GO:0010508)2.54757821
149amyloid precursor protein metabolic process (GO:0042982)2.53837704
150cell migration in hindbrain (GO:0021535)2.53690398
151termination of RNA polymerase III transcription (GO:0006386)2.53312690
152transcription elongation from RNA polymerase III promoter (GO:0006385)2.53312690
153regulation of sulfur metabolic process (GO:0042762)2.53024432
154dorsal/ventral neural tube patterning (GO:0021904)2.51959310
155mesenchyme morphogenesis (GO:0072132)2.51678694
156T-helper cell differentiation (GO:0042093)2.50928107
157CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.50928107
158detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.50890561
159detection of temperature stimulus involved in sensory perception (GO:0050961)2.50890561
160endocrine hormone secretion (GO:0060986)2.50443697
161positive regulation of glycogen metabolic process (GO:0070875)2.50183583
162semaphorin-plexin signaling pathway (GO:0071526)2.49668923
163regulation of synaptic vesicle exocytosis (GO:2000300)2.49490487
164synaptic vesicle exocytosis (GO:0016079)2.48674269
165diterpenoid biosynthetic process (GO:0016102)2.48096001
166positive regulation of mitochondrial membrane permeability (GO:0035794)2.47688640
167transcription from mitochondrial promoter (GO:0006390)2.47520701
168negative regulation of inclusion body assembly (GO:0090084)2.45193577
169GDP-mannose metabolic process (GO:0019673)2.44558258
170innervation (GO:0060384)2.44023285
171blastocyst development (GO:0001824)2.43461490
172meiotic cell cycle process (GO:1903046)2.42753759
173positive regulation of epidermis development (GO:0045684)2.42657280
174L-amino acid import (GO:0043092)2.41708115
175regulation of collateral sprouting (GO:0048670)2.41083896
176folic acid transport (GO:0015884)2.41042444
177GMP metabolic process (GO:0046037)2.41012029
178auditory behavior (GO:0031223)2.39097195
179mitotic spindle assembly checkpoint (GO:0007094)2.39047915
180pentose metabolic process (GO:0019321)2.38981916
181pharyngeal system development (GO:0060037)2.38903131
182mitotic spindle checkpoint (GO:0071174)2.38886105
183membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.38881922
184desmosome organization (GO:0002934)2.38430136
185positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.37006884
186oocyte development (GO:0048599)2.36669109
187negative regulation of chromosome segregation (GO:0051985)2.35579332
188heme transport (GO:0015886)2.34544716
189sodium ion export (GO:0071436)2.33748213
190transcription from RNA polymerase I promoter (GO:0006360)2.33631062
191startle response (GO:0001964)2.33477792
192negative regulation of meiosis (GO:0045835)2.32563529
193neurotransmitter catabolic process (GO:0042135)2.31978847
194negative regulation of mitotic sister chromatid separation (GO:2000816)2.31906935
195negative regulation of mitotic sister chromatid segregation (GO:0033048)2.31906935
196negative regulation of sister chromatid segregation (GO:0033046)2.31906935

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_21235772_ChIP-Seq_MCF-7_Human6.92447805
2ESR1_20079471_ChIP-ChIP_T-47D_Human6.14979559
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.54882590
4ESR1_15608294_ChIP-ChIP_MCF-7_Human5.16278665
5TFAP2C_20629094_ChIP-Seq_MCF-7_Human4.28511609
6ZNF217_24962896_ChIP-Seq_MCF-7_Human3.94586217
7* AHR_22903824_ChIP-Seq_MCF-7_Human3.94113154
8RUNX1_27514584_Chip-Seq_MCF-7_Human3.58028710
9HIF1A_21447827_ChIP-Seq_MCF-7_Human3.54917931
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.44675954
11ER_23166858_ChIP-Seq_MCF-7_Human3.31193194
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.22906600
13* ARNT_22903824_ChIP-Seq_MCF-7_Human3.08814682
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.99394369
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.89560949
16* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.86023132
17ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.78740338
18* TDRD3_21172665_ChIP-Seq_MCF-7_Human2.76583159
19* PKCTHETA_26484144_Chip-Seq_BREAST_Human2.74391058
20RACK7_27058665_Chip-Seq_MCF-7_Human2.72497937
21GATA1_26923725_Chip-Seq_HPCs_Mouse2.69556546
22GATA3_24758297_ChIP-Seq_MCF-7_Human2.53143140
23POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.48725200
24YY1_21170310_ChIP-Seq_MESCs_Mouse2.23264519
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.18399608
26ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.17439810
27EZH2_22144423_ChIP-Seq_EOC_Human2.16125599
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.15669275
29TP63_17297297_ChIP-ChIP_HaCaT_Human2.10811272
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.08252194
31NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.07512274
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.01778795
33* EST1_17652178_ChIP-ChIP_JURKAT_Human1.97506789
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.97053844
35SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.96810884
36FOXM1_26456572_ChIP-Seq_MCF-7_Human1.93649094
37SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.86404580
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.85946267
39ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.83324013
40KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.83076343
41BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.77828691
42KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.77218276
43KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.77218276
44KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.77218276
45ZNF263_19887448_ChIP-Seq_K562_Human1.76264533
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72507180
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72482134
48REST_21632747_ChIP-Seq_MESCs_Mouse1.71718674
49CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.71219527
50NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.64884409
51REST_18959480_ChIP-ChIP_MESCs_Mouse1.63541328
52* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62574445
53SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.61807934
54* DROSHA_22980978_ChIP-Seq_HELA_Human1.61742698
55* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.61178282
56KDM5A_27292631_Chip-Seq_BREAST_Human1.58992067
57* RARB_27405468_Chip-Seq_BRAIN_Mouse1.50767295
58* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50764924
59SMC4_20622854_ChIP-Seq_HELA_Human1.49484329
60CIITA_25753668_ChIP-Seq_RAJI_Human1.48396532
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.48265089
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48237744
63NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.46754262
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42455247
65GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.39643335
66* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.38352049
67GBX2_23144817_ChIP-Seq_PC3_Human1.36582747
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36415129
69GABP_17652178_ChIP-ChIP_JURKAT_Human1.34690334
70CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.32901087
71CREB1_26743006_Chip-Seq_LNCaP_Human1.31017301
72SRF_21415370_ChIP-Seq_HL-1_Mouse1.29291301
73RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.28807759
74* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28611672
75P68_20966046_ChIP-Seq_HELA_Human1.27602965
76* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27538606
77NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.27006507
78MYC_18358816_ChIP-ChIP_MESCs_Mouse1.26674976
79KLF5_25053715_ChIP-Seq_YYC3_Human1.24202417
80* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.23652799
81SOX2_18692474_ChIP-Seq_MESCs_Mouse1.22983911
82HOXB7_26014856_ChIP-Seq_BT474_Human1.20684816
83NANOG_21062744_ChIP-ChIP_HESCs_Human1.20642867
84MYC_19079543_ChIP-ChIP_MESCs_Mouse1.19921707
85EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19144960
86* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18819681
87* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.17597171
88RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.16927055
89HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.15152884
90TET1_21490601_ChIP-Seq_MESCs_Mouse1.15095015
91FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.14827194
92SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.13497273
93TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.13113621
94ERG_21242973_ChIP-ChIP_JURKAT_Human1.11684868
95SALL1_21062744_ChIP-ChIP_HESCs_Human1.11254279
96SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10620155
97KLF4_19829295_ChIP-Seq_ESCs_Human1.10421573
98SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.09463803
99GABP_19822575_ChIP-Seq_HepG2_Human1.08770113
100AR_21909140_ChIP-Seq_LNCAP_Human1.06768276
101TCF7_22412390_ChIP-Seq_EML_Mouse1.05884782
102EOMES_21245162_ChIP-Seq_HESCs_Human1.05382534
103FOXH1_21741376_ChIP-Seq_ESCs_Human1.05371092
104SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.05087897
105* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.05064785
106* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05005791
107POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.04403858
108ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03432770
109VDR_23849224_ChIP-Seq_CD4+_Human1.03091581
110ESR2_21235772_ChIP-Seq_MCF-7_Human1.02303791
111TCF3_18692474_ChIP-Seq_MESCs_Mouse1.01268522
112MYC_18555785_ChIP-Seq_MESCs_Mouse1.00797224
113TET1_21451524_ChIP-Seq_MESCs_Mouse1.00751015
114KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99829796
115RAC3_21632823_ChIP-Seq_H3396_Human0.98814255
116DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98602565
117ELF5_23300383_ChIP-Seq_T47D_Human0.98163120
118GATA6_25053715_ChIP-Seq_YYC3_Human0.97770260
119CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97290679
120OCT4_19829295_ChIP-Seq_ESCs_Human0.96785387
121* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.96593228
122ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96047584
123P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95823899
124NANOG_18692474_ChIP-Seq_MEFs_Mouse0.95761921
125KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95588222
126TP53_20018659_ChIP-ChIP_R1E_Mouse0.95199675
127KAP1_27257070_Chip-Seq_ESCs_Mouse0.94606980
128SOX2_18692474_ChIP-Seq_MEFs_Mouse0.94603643
129KDM2B_26808549_Chip-Seq_K562_Human0.94326111
130MYCN_18555785_ChIP-Seq_MESCs_Mouse0.94152746
131RNF2_27304074_Chip-Seq_ESCs_Mouse0.94114033
132TP63_22573176_ChIP-Seq_HFKS_Human0.94088316
133YY1_22570637_ChIP-Seq_MALME-3M_Human0.94010414
134EZH2_27294783_Chip-Seq_ESCs_Mouse0.93924962
135* LXR_22292898_ChIP-Seq_THP-1_Human0.93295695
136TP63_19390658_ChIP-ChIP_HaCaT_Human0.92237237
137STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91155192
138ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.90566703
139* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90324708
140CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90115882
141SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90108020
142E2F1_17053090_ChIP-ChIP_MCF-7_Human0.89714937
143ERA_21632823_ChIP-Seq_H3396_Human0.88844487
144POU5F1_16153702_ChIP-ChIP_HESCs_Human0.88784425
145* CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.88685758
146GATA3_21867929_ChIP-Seq_CD8_Mouse0.88685382
147GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.88527581
148XRN2_22483619_ChIP-Seq_HELA_Human0.88378664
149STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.88052599
150MYC_19030024_ChIP-ChIP_MESCs_Mouse0.86148444
151* MITF_21258399_ChIP-Seq_MELANOMA_Human0.86094702
152KAP1_22055183_ChIP-Seq_ESCs_Mouse0.85782844
153TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.84644530
154SUZ12_27294783_Chip-Seq_ESCs_Mouse0.84627314
155TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84153771
156CTCF_26484167_Chip-Seq_Bcells_Mouse0.81932446
157KDM2B_26808549_Chip-Seq_DND41_Human0.81808914
158KDM2B_26808549_Chip-Seq_SUP-B15_Human0.81451259
159OCT4_20526341_ChIP-Seq_ESCs_Human0.80557306
160MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.80365525
161THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.76204854
162TP53_22573176_ChIP-Seq_HFKS_Human0.75986833
163JARID2_20075857_ChIP-Seq_MESCs_Mouse0.74511056
164* FOXA2_19822575_ChIP-Seq_HepG2_Human0.74015643
165FOXP1_21924763_ChIP-Seq_HESCs_Human0.73614405
166CTCF_27219007_Chip-Seq_Bcells_Human0.73165067
167P63_26484246_Chip-Seq_KERATINOCYTES_Human0.73127403
168DNAJC2_21179169_ChIP-ChIP_NT2_Human0.72958103
169NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.72028278
170* AR_19668381_ChIP-Seq_PC3_Human0.71786859
171* GATA1_19941827_ChIP-Seq_MEL_Mouse0.71569560
172SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.70612195
173CTCF_18555785_ChIP-Seq_MESCs_Mouse0.69125405
174E2F1_20622854_ChIP-Seq_HELA_Human0.68543121
175CTCF_21964334_ChIP-Seq_BJAB-B_Human0.65121936
176* RARB_24833708_ChIP-Seq_LIVER_Mouse0.64936681
177CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.62631145
178RING1B_27294783_Chip-Seq_NPCs_Mouse0.62508150
179* FOXA1_25552417_ChIP-Seq_VCAP_Human0.62312582
180FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.62218098
181* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.61901275
182SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.61463934

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004381_abnormal_hair_follicle4.47348202
2MP0009780_abnormal_chondrocyte_physiolo3.81406705
3MP0000383_abnormal_hair_follicle3.79937654
4MP0008260_abnormal_autophagy3.68487266
5MP0005075_abnormal_melanosome_morpholog3.46904182
6MP0008877_abnormal_DNA_methylation3.27488327
7MP0004859_abnormal_synaptic_plasticity3.03567355
8MP0004264_abnormal_extraembryonic_tissu2.92945671
9MP0000427_abnormal_hair_cycle2.73419291
10MP0003718_maternal_effect2.61340923
11MP0010678_abnormal_skin_adnexa2.60836648
12MP0002098_abnormal_vibrissa_morphology2.59013676
13MP0000462_abnormal_digestive_system2.54714810
14MP0002796_impaired_skin_barrier2.53509669
15MP0009840_abnormal_foam_cell2.52010757
16MP0003787_abnormal_imprinting2.50008129
17MP0002653_abnormal_ependyma_morphology2.45059981
18MP0005646_abnormal_pituitary_gland2.44173554
19MP0004270_analgesia2.43583425
20MP0003123_paternal_imprinting2.43220572
21MP0005423_abnormal_somatic_nervous2.35403448
22MP0001968_abnormal_touch/_nociception2.35083033
23MP0004885_abnormal_endolymph2.32213732
24MP0002736_abnormal_nociception_after2.30862626
25MP0005076_abnormal_cell_differentiation2.26053047
26MP0003635_abnormal_synaptic_transmissio2.17787192
27MP0004145_abnormal_muscle_electrophysio2.17446504
28MP0003880_abnormal_central_pattern2.17197110
29MP0003111_abnormal_nucleus_morphology2.07669836
30MP0002249_abnormal_larynx_morphology2.05597557
31MP0005408_hypopigmentation2.01836647
32MP0009046_muscle_twitch1.98009463
33MP0002064_seizures1.97674297
34MP0004036_abnormal_muscle_relaxation1.93845615
35MP0003656_abnormal_erythrocyte_physiolo1.88891142
36MP0002734_abnormal_mechanical_nocicepti1.88596370
37MP0002272_abnormal_nervous_system1.85710374
38MP0001873_stomach_inflammation1.80898672
39MP0003646_muscle_fatigue1.78808364
40MP0009745_abnormal_behavioral_response1.78424965
41MP0003329_amyloid_beta_deposits1.77738436
42MP0001529_abnormal_vocalization1.75911649
43MP0002063_abnormal_learning/memory/cond1.74587957
44MP0002822_catalepsy1.73564758
45MP0000538_abnormal_urinary_bladder1.72375919
46MP0004233_abnormal_muscle_weight1.72232287
47MP0002909_abnormal_adrenal_gland1.70033469
48MP0002735_abnormal_chemical_nociception1.64445414
49MP0003705_abnormal_hypodermis_morpholog1.58845188
50MP0004084_abnormal_cardiac_muscle1.57134723
51MP0001486_abnormal_startle_reflex1.56561846
52MP0005248_abnormal_Harderian_gland1.54233340
53MP0000579_abnormal_nail_morphology1.53089973
54MP0000371_diluted_coat_color1.52308855
55MP0003786_premature_aging1.48611203
56MP0004215_abnormal_myocardial_fiber1.45811597
57MP0001440_abnormal_grooming_behavior1.44727919
58MP0000470_abnormal_stomach_morphology1.43825026
59MP0005501_abnormal_skin_physiology1.42832818
60MP0002751_abnormal_autonomic_nervous1.42249386
61MP0003942_abnormal_urinary_system1.41125533
62MP0002572_abnormal_emotion/affect_behav1.40457442
63MP0005083_abnormal_biliary_tract1.37442768
64MP0002160_abnormal_reproductive_system1.36827616
65MP0003698_abnormal_male_reproductive1.36716562
66MP0001664_abnormal_digestion1.36536985
67MP0000377_abnormal_hair_follicle1.36502156
68MP0001970_abnormal_pain_threshold1.36026943
69MP0001905_abnormal_dopamine_level1.35899380
70MP0001929_abnormal_gametogenesis1.35388107
71MP0000747_muscle_weakness1.35368686
72MP0003693_abnormal_embryo_hatching1.35072443
73MP0004147_increased_porphyrin_level1.34765300
74MP0003950_abnormal_plasma_membrane1.33573683
75MP0002269_muscular_atrophy1.32179729
76MP0002067_abnormal_sensory_capabilities1.29615713
77MP0002210_abnormal_sex_determination1.29094425
78MP0000751_myopathy1.29061829
79MP0001348_abnormal_lacrimal_gland1.27230129
80MP0003866_abnormal_defecation1.23374441
81MP0003806_abnormal_nucleotide_metabolis1.23101844
82MP0002229_neurodegeneration1.21831846
83MP0002733_abnormal_thermal_nociception1.21815622
84MP0003690_abnormal_glial_cell1.21216480
85MP0003936_abnormal_reproductive_system1.20956777
86MP0005332_abnormal_amino_acid1.20540062
87MP0000627_abnormal_mammary_gland1.20439267
88MP0001661_extended_life_span1.19874193
89MP0004957_abnormal_blastocyst_morpholog1.19837244
90MP0003183_abnormal_peptide_metabolism1.19689283
91MP0008872_abnormal_physiological_respon1.19660735
92MP0008569_lethality_at_weaning1.18763243
93MP0001145_abnormal_male_reproductive1.17703460
94MP0008995_early_reproductive_senescence1.17418105
95MP0008875_abnormal_xenobiotic_pharmacok1.16950628
96MP0002075_abnormal_coat/hair_pigmentati1.16452866
97MP0005171_absent_coat_pigmentation1.14482513
98MP0002089_abnormal_postnatal_growth/wei1.13822861
99MP0001502_abnormal_circadian_rhythm1.12409515
100MP0000749_muscle_degeneration1.08601360
101MP0004782_abnormal_surfactant_physiolog1.08045264
102MP0003631_nervous_system_phenotype1.08000093
103MP0003632_abnormal_nervous_system1.07894351
104MP0005551_abnormal_eye_electrophysiolog1.07486637
105MP0002837_dystrophic_cardiac_calcinosis1.06446738
106MP0004142_abnormal_muscle_tone1.05511280
107MP0000534_abnormal_ureter_morphology1.05005194
108MP0000653_abnormal_sex_gland1.04677208
109MP0009672_abnormal_birth_weight1.04644651
110MP0005410_abnormal_fertilization1.04048547
111MP0009115_abnormal_fat_cell1.04026857
112MP0000467_abnormal_esophagus_morphology1.04015415
113MP0009384_cardiac_valve_regurgitation1.02120474
114MP0008058_abnormal_DNA_repair1.01875339
115MP0006138_congestive_heart_failure1.01538198
116MP0005670_abnormal_white_adipose1.00427820
117MP0000778_abnormal_nervous_system1.00021974
118MP0002184_abnormal_innervation1.00001850
119MP0001727_abnormal_embryo_implantation0.99464855
120MP0002066_abnormal_motor_capabilities/c0.98161396
121MP0010094_abnormal_chromosome_stability0.98059308
122MP0001919_abnormal_reproductive_system0.97888521
123MP0004043_abnormal_pH_regulation0.97578108
124MP0003077_abnormal_cell_cycle0.97155471
125MP0000920_abnormal_myelination0.97147886
126MP0010030_abnormal_orbit_morphology0.95884091
127MP0002161_abnormal_fertility/fecundity0.95670951
128MP0003136_yellow_coat_color0.93985058
129MP0003634_abnormal_glial_cell0.93605024
130MP0003638_abnormal_response/metabolism_0.92990724
131MP0002332_abnormal_exercise_endurance0.92955324
132MP0006035_abnormal_mitochondrial_morpho0.92540540
133MP0003633_abnormal_nervous_system0.90955902
134MP0005058_abnormal_lysosome_morphology0.89605889
135MP0002108_abnormal_muscle_morphology0.89163398
136MP0005085_abnormal_gallbladder_physiolo0.88878804
137MP0009703_decreased_birth_body0.87946754
138MP0000955_abnormal_spinal_cord0.86934001
139MP0005395_other_phenotype0.86635232
140MP0006036_abnormal_mitochondrial_physio0.86539299
141MP0002127_abnormal_cardiovascular_syste0.86078075
142MP0001186_pigmentation_phenotype0.85656009
143MP0004924_abnormal_behavior0.85632258
144MP0005386_behavior/neurological_phenoty0.85632258
145MP0000750_abnormal_muscle_regeneration0.85303224
146MP0008057_abnormal_DNA_replication0.85302376
147MP0001485_abnormal_pinna_reflex0.85208311
148MP0004085_abnormal_heartbeat0.85072732
149MP0008932_abnormal_embryonic_tissue0.84561154
150MP0005377_hearing/vestibular/ear_phenot0.84349785
151MP0003878_abnormal_ear_physiology0.84349785
152MP0000569_abnormal_digit_pigmentation0.84079742
153MP0001730_embryonic_growth_arrest0.81392619
154MP0005330_cardiomyopathy0.80030917
155MP0005365_abnormal_bile_salt0.79859677
156MP0000372_irregular_coat_pigmentation0.79097255
157MP0002970_abnormal_white_adipose0.78994804
158MP0003137_abnormal_impulse_conducting0.78820254
159MP0003699_abnormal_female_reproductive0.78662123
160MP0010771_integument_phenotype0.77318796
161MP0003115_abnormal_respiratory_system0.76305539
162MP0000015_abnormal_ear_pigmentation0.75716803
163MP0005451_abnormal_body_composition0.75198419
164MP0008961_abnormal_basal_metabolism0.71465670
165MP0001340_abnormal_eyelid_morphology0.67990196
166MP0003879_abnormal_hair_cell0.66413806
167MP0001944_abnormal_pancreas_morphology0.65675515
168MP0000647_abnormal_sebaceous_gland0.62953216
169MP0000367_abnormal_coat/_hair0.62632264
170MP0005409_darkened_coat_color0.59169944
171MP0004133_heterotaxia0.57382231
172MP0005174_abnormal_tail_pigmentation0.56840138

Predicted human phenotypes

RankGene SetZ-score
1J-shaped sella turcica (HP:0002680)8.04804679
2Septate vagina (HP:0001153)5.66199975
3Absent frontal sinuses (HP:0002688)5.52010010
4Asymmetry of the thorax (HP:0001555)5.17621033
5Concave nail (HP:0001598)5.16517389
6Deformed sella turcica (HP:0002681)4.85626939
7Cerebral hypomyelination (HP:0006808)4.84523328
8Micronodular cirrhosis (HP:0001413)4.50421940
9Microglossia (HP:0000171)4.42205096
10Hyperglycinemia (HP:0002154)4.20389574
11Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)4.02113819
12Abnormality of the sella turcica (HP:0002679)3.77125612
13Abnormality of the frontal sinuses (HP:0002687)3.73856823
14Hyperglycinuria (HP:0003108)3.73292981
15Breast carcinoma (HP:0003002)3.63200923
16Breast hypoplasia (HP:0003187)3.59918249
17Abnormality of the lower motor neuron (HP:0002366)3.56396363
18Myokymia (HP:0002411)3.52405883
19Increased neuronal autofluorescent lipopigment (HP:0002074)3.52082517
20Delusions (HP:0000746)3.42775810
21Macroorchidism (HP:0000053)3.41597278
22Long toe (HP:0010511)3.32111571
23Hyperventilation (HP:0002883)3.30241461
24Abnormality of serine family amino acid metabolism (HP:0010894)3.24802224
25Abnormality of glycine metabolism (HP:0010895)3.24802224
26Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.24730330
27Amelogenesis imperfecta (HP:0000705)3.22283484
28Focal motor seizures (HP:0011153)3.20256220
29Chromosomal breakage induced by crosslinking agents (HP:0003221)3.15204178
30Germ cell neoplasia (HP:0100728)3.14566967
31Ventricular fibrillation (HP:0001663)3.01397507
32Esophageal varix (HP:0002040)3.00482224
33Ureteral duplication (HP:0000073)2.99785784
34Abnormality of the labia minora (HP:0012880)2.99291102
35Impulsivity (HP:0100710)2.98558002
36CNS hypomyelination (HP:0003429)2.93341722
37Spastic tetraparesis (HP:0001285)2.92633092
38Testicular neoplasm (HP:0010788)2.91466275
39Enlarged penis (HP:0000040)2.87654790
40Chromsome breakage (HP:0040012)2.87343173
41Hypopigmentation of the fundus (HP:0007894)2.83414719
42Focal seizures (HP:0007359)2.80444566
43Spastic paraparesis (HP:0002313)2.80192548
44Abnormality of the corticospinal tract (HP:0002492)2.79931022
45Birth length less than 3rd percentile (HP:0003561)2.79718959
46Gout (HP:0001997)2.76219806
47Spastic gait (HP:0002064)2.75644257
48Genetic anticipation (HP:0003743)2.75454291
49Increased cerebral lipofuscin (HP:0011813)2.75039351
50Abdominal distention (HP:0003270)2.73026916
51Ulnar claw (HP:0001178)2.70677703
52Azoospermia (HP:0000027)2.68762687
53Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.67061589
54Muscle fiber splitting (HP:0003555)2.63720630
55Aplasia/Hypoplasia of the tongue (HP:0010295)2.62616234
56Poor speech (HP:0002465)2.61382877
57Tetraplegia (HP:0002445)2.60055411
58Bundle branch block (HP:0011710)2.58376099
59Bicornuate uterus (HP:0000813)2.58086066
60Dynein arm defect of respiratory motile cilia (HP:0012255)2.57870697
61Absent/shortened dynein arms (HP:0200106)2.57870697
62Distal lower limb muscle weakness (HP:0009053)2.54910218
63Abnormality of serum amino acid levels (HP:0003112)2.54201853
64Atrioventricular block (HP:0001678)2.49893543
65Dysautonomia (HP:0002459)2.49579804
66Midline defect of the nose (HP:0004122)2.47655504
67Absent radius (HP:0003974)2.46294769
68Submucous cleft hard palate (HP:0000176)2.44823926
69Paraparesis (HP:0002385)2.44489068
70Abnormal spermatogenesis (HP:0008669)2.42687195
71Renal dysplasia (HP:0000110)2.41924524
72Male infertility (HP:0003251)2.41295528
73Cutaneous melanoma (HP:0012056)2.40564758
74Oligodactyly (hands) (HP:0001180)2.40152118
75Epileptic encephalopathy (HP:0200134)2.39906125
76Buphthalmos (HP:0000557)2.39821613
77Ankle clonus (HP:0011448)2.37629940
78Abnormality of cochlea (HP:0000375)2.37468728
79Lymphangioma (HP:0100764)2.37114615
80Morphological abnormality of the inner ear (HP:0011390)2.36063369
81Aplasia involving forearm bones (HP:0009822)2.32760104
82Absent forearm bone (HP:0003953)2.32760104
83Unsteady gait (HP:0002317)2.32236964
84Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.29093143
85Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.27319524
86Hypoparathyroidism (HP:0000829)2.26359017
87Progressive cerebellar ataxia (HP:0002073)2.24576136
88Abnormal ciliary motility (HP:0012262)2.23735605
89Tented upper lip vermilion (HP:0010804)2.21040651
90Curly hair (HP:0002212)2.19505888
91Abnormality of alanine metabolism (HP:0010916)2.18831726
92Hyperalaninemia (HP:0003348)2.18831726
93Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.18831726
94Abnormal respiratory motile cilium physiology (HP:0012261)2.18718904
95Carpal bone hypoplasia (HP:0001498)2.18218833
96Degeneration of the lateral corticospinal tracts (HP:0002314)2.17707432
97Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.17707432
98Urinary urgency (HP:0000012)2.15792298
99Hypercortisolism (HP:0001578)2.15632416
100Hyporeflexia of lower limbs (HP:0002600)2.15324407
101Abnormal respiratory motile cilium morphology (HP:0005938)2.14790722
102Abnormal respiratory epithelium morphology (HP:0012253)2.14790722
103Supranuclear gaze palsy (HP:0000605)2.14787043
104Abnormality of the umbilical cord (HP:0010881)2.14423933
105Ependymoma (HP:0002888)2.13040855
106Segmental peripheral demyelination/remyelination (HP:0003481)2.11365572
107Prolonged neonatal jaundice (HP:0006579)2.09891053
108Premature ovarian failure (HP:0008209)2.09071735
109External ophthalmoplegia (HP:0000544)2.08790257
110Agitation (HP:0000713)2.08372334
111Thyroid carcinoma (HP:0002890)2.08239275
112Generalized tonic-clonic seizures (HP:0002069)2.07927137
113Dysmetria (HP:0001310)2.07901749
114Hyperacusis (HP:0010780)2.07602023
115Atonic seizures (HP:0010819)2.07342374
116Onion bulb formation (HP:0003383)2.07032474
117Shawl scrotum (HP:0000049)2.06346310
118Progressive muscle weakness (HP:0003323)2.04575922
119Lip pit (HP:0100267)2.01782192
120High pitched voice (HP:0001620)2.00685088
121Dialeptic seizures (HP:0011146)1.98883531
122Diaphragmatic weakness (HP:0009113)1.98010985
123Visual hallucinations (HP:0002367)1.97566598
124Papillary thyroid carcinoma (HP:0002895)1.97247206
125Cystic liver disease (HP:0006706)1.95603503
126Bell-shaped thorax (HP:0001591)1.94841014
127Heterochromia iridis (HP:0001100)1.94732131
128Areflexia of lower limbs (HP:0002522)1.93252796
129Abnormality of the aortic arch (HP:0012303)1.92070638
130Urinary bladder sphincter dysfunction (HP:0002839)1.91915853
131Truncal obesity (HP:0001956)1.91597337
132Aplasia/Hypoplasia involving the musculature (HP:0001460)1.91407268
133Rhinitis (HP:0012384)1.90828408
134Progressive external ophthalmoplegia (HP:0000590)1.89438613
135CNS demyelination (HP:0007305)1.87855615
136Neoplasm of the thyroid gland (HP:0100031)1.86901791
137Chronic hepatic failure (HP:0100626)1.86485625
138Menstrual irregularities (HP:0000858)1.86346279
139Febrile seizures (HP:0002373)1.85621145
140Impaired social interactions (HP:0000735)1.85569393
141Abnormal social behavior (HP:0012433)1.85569393
142Clonus (HP:0002169)1.83874996
143Heart block (HP:0012722)1.83215655
144Reticulocytosis (HP:0001923)1.83001489
145Abnormality of dental color (HP:0011073)1.82601741
146Exercise-induced myalgia (HP:0003738)1.82316060
147Status epilepticus (HP:0002133)1.81694563
148Pancreatic cysts (HP:0001737)1.80905657
149Aplasia/Hypoplasia of the patella (HP:0006498)1.80530615
150Patellar aplasia (HP:0006443)1.80376779
151Tubulointerstitial nephritis (HP:0001970)1.80235566
152Death in infancy (HP:0001522)1.80106343
153Emotional lability (HP:0000712)1.80045481
154Confusion (HP:0001289)1.79301185
155EMG: neuropathic changes (HP:0003445)1.77166994
156Impaired pain sensation (HP:0007328)1.76650745
157Abnormality of pain sensation (HP:0010832)1.76650745
158Distal sensory impairment (HP:0002936)1.76366752
159Spastic paraplegia (HP:0001258)1.76256179
160Syncope (HP:0001279)1.75864044
161Difficulty running (HP:0009046)1.75836870
162Peripheral hypomyelination (HP:0007182)1.75688120
163Cerebellar dysplasia (HP:0007033)1.75306502
164Thin bony cortex (HP:0002753)1.74667661
165Mutism (HP:0002300)1.74496448
166Postural instability (HP:0002172)1.73178448
167Spastic tetraplegia (HP:0002510)1.72585282
168Hyperparathyroidism (HP:0000843)1.72415975
169Neoplasm of the adrenal cortex (HP:0100641)1.71523972
170Entropion (HP:0000621)1.71282839
171Spinal cord compression (HP:0002176)1.70569663
172Breast aplasia (HP:0100783)1.70532694
173Excessive salivation (HP:0003781)1.70359147
174Drooling (HP:0002307)1.70359147
175Gaze-evoked nystagmus (HP:0000640)1.69880387
176Athetosis (HP:0002305)1.69225094
177Restlessness (HP:0000711)1.69185273
178Abnormality of the carotid arteries (HP:0005344)1.68537061
179Goiter (HP:0000853)1.67306868
180Aplasia/Hypoplasia of the uvula (HP:0010293)1.64669996
181Down-sloping shoulders (HP:0200021)1.64498735
182Broad distal phalanx of finger (HP:0009836)1.62347643
183Morphological abnormality of the middle ear (HP:0008609)1.61754279
184Spinal cord lesions (HP:0100561)1.56193416
185Syringomyelia (HP:0003396)1.56193416
186Self-mutilation (HP:0000742)1.55900109
187Short thumb (HP:0009778)1.55361592
188Open mouth (HP:0000194)1.54950115
189Astigmatism (HP:0000483)1.53528395
190Insidious onset (HP:0003587)1.53069113
191Termporal pattern (HP:0011008)1.53069113
192Cone-rod dystrophy (HP:0000548)1.52668114
193Absent thumb (HP:0009777)1.52259452

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB36.33612218
2AKT35.51286605
3PKN24.49401261
4RPS6KB24.01587883
5PIK3CA3.96073959
6SIK13.85448275
7PRPF4B3.73127649
8BUB13.63004798
9MUSK3.55789671
10SCYL23.52709931
11PINK12.95975058
12TSSK62.77680142
13PDK42.75802431
14PDK32.75802431
15MAP2K22.70768691
16NEK12.55139824
17ARAF2.46637290
18BCKDK2.40333722
19PNCK2.27370910
20EPHA22.27356976
21CDK122.20125505
22SMG12.05588486
23PDK22.05528200
24EPHA42.04586245
25MAP3K92.03053337
26WEE12.01894288
27FRK1.94317710
28BRAF1.91505583
29NTRK31.82316807
30EEF2K1.72779420
31CHUK1.69436071
32GRK61.67733026
33STK38L1.57853923
34MAP3K41.54540697
35LATS21.51719058
36MAP3K121.50415456
37SIK31.49521631
38BRSK11.47107463
39LMTK21.44444042
40STK381.36220732
41MAP2K11.32547600
42TESK11.30349530
43TESK21.26157311
44PAK61.23504451
45GRK51.23343268
46RPS6KA21.23196687
47VRK21.20361705
48FGFR21.19489164
49NTRK21.17693085
50NME21.13188501
51PLK11.12990021
52NTRK11.10482260
53TRIM281.07455847
54STK161.06523311
55ZAK1.04909110
56OXSR11.03272873
57RPS6KB11.02985602
58NEK21.01915252
59KSR21.01148571
60MTOR1.01063141
61CAMK2B1.00971368
62CAMKK10.98779200
63TTK0.98491504
64CDK190.95869506
65SGK2230.94927218
66SGK4940.94927218
67STK390.94685466
68ILK0.94245758
69PLK30.91882820
70RET0.91508272
71TNK20.91485904
72PLK40.87636163
73KSR10.86451698
74MINK10.85639709
75PTK60.85593608
76MAP2K40.83186421
77PRKAA10.77865684
78MAP2K70.77619148
79FGFR40.75266602
80CAMK2D0.73904863
81CDK50.73442756
82PHKG10.73153286
83PHKG20.73153286
84CDK70.71964979
85RAF10.71242228
86NEK60.70330672
87CSF1R0.69817193
88EIF2AK10.69671949
89IKBKB0.69669145
90PRKCG0.69301621
91RIPK40.67256383
92AURKA0.67206021
93MARK10.65668879
94MAPKAPK20.63350547
95STK110.62955416
96PDPK10.62462630
97ICK0.61516731
98FER0.61472089
99PDK10.59787688
100CSNK1E0.58549695
101MAPK150.58396149
102PRKCZ0.58378889
103SGK20.55673305
104LRRK20.54743508
105MAPKAPK30.54310036
106PRKD10.53777137
107SGK30.53465175
108RPS6KA60.53111449
109BCR0.52608945
110MAP3K130.51640430
111TAF10.51490223
112IKBKE0.51211317
113NME10.50905148
114IRAK20.50414146
115RPS6KC10.50118888
116RPS6KL10.50118888
117CSNK1D0.48603406
118MAPK100.48036636
119PAK10.46933316
120PRKD20.46778747
121DAPK20.46619801
122CDK180.46348531
123CAMK2G0.44991588
124MELK0.44800654
125DAPK10.44260158
126MARK30.43880916
127BRD40.43762096
128CSNK1G30.43568439
129PKN10.43530718
130MET0.43326595
131MAPK80.43128425
132PRKD30.42664512
133CSNK1G20.42455598
134CHEK20.42370023
135HIPK20.42040061
136CDK150.41731956
137WNK10.41538238
138CDK140.40383074
139LIMK10.39139329
140PRKCI0.38871801
141CASK0.38605174
142UHMK10.38509488
143PAK30.38189828
144MAPK110.37396167
145OBSCN0.36648177
146RPS6KA10.36205923
147CCNB10.36107329
148NUAK10.35622908
149GRK10.35184568
150CHEK10.34857781
151MAP3K20.33905928
152CAMK2A0.33747379
153DYRK1A0.33247259
154CDK30.32432472
155CSNK1A1L0.32189120
156IRAK30.32149779
157TYRO30.32065696
158PAK40.31915481
159SIK20.31207856
160CDK11A0.30963037
161MAPKAPK50.30830951
162CAMK10.29853204
163PIM20.28210577
164DMPK0.27536560
165AKT20.24981730
166TAOK10.22968073
167MAPK90.22679984
168TAOK30.22073960
169MAPK140.21620214
170TBK10.21561159
171GSK3B0.20387289
172MAPK30.17483744
173INSRR0.17113099
174MAPK40.16869626

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.90033826
2Regulation of autophagy_Homo sapiens_hsa041402.86593220
3RNA polymerase_Homo sapiens_hsa030202.61863275
4Endometrial cancer_Homo sapiens_hsa052132.50785899
5Acute myeloid leukemia_Homo sapiens_hsa052212.28975697
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.21114106
7Glycerophospholipid metabolism_Homo sapiens_hsa005642.17790319
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.17585299
9Synaptic vesicle cycle_Homo sapiens_hsa047212.08826420
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.04945103
11Thyroid cancer_Homo sapiens_hsa052162.04757832
12AMPK signaling pathway_Homo sapiens_hsa041521.99256804
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.96285625
14Non-small cell lung cancer_Homo sapiens_hsa052231.93695672
15Choline metabolism in cancer_Homo sapiens_hsa052311.82200989
16Fructose and mannose metabolism_Homo sapiens_hsa000511.79136846
17Estrogen signaling pathway_Homo sapiens_hsa049151.77970787
18Nicotine addiction_Homo sapiens_hsa050331.73216086
19Proteasome_Homo sapiens_hsa030501.71716529
20Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.70829722
21Glioma_Homo sapiens_hsa052141.69004041
22ABC transporters_Homo sapiens_hsa020101.66786374
23Ovarian steroidogenesis_Homo sapiens_hsa049131.65637425
24VEGF signaling pathway_Homo sapiens_hsa043701.65066111
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.64941562
26Collecting duct acid secretion_Homo sapiens_hsa049661.56041424
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.53630552
28Insulin resistance_Homo sapiens_hsa049311.53046668
29Circadian rhythm_Homo sapiens_hsa047101.50992298
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.50934327
31RNA transport_Homo sapiens_hsa030131.47773235
32Insulin signaling pathway_Homo sapiens_hsa049101.44502187
33Biosynthesis of amino acids_Homo sapiens_hsa012301.43784899
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.42122691
35GABAergic synapse_Homo sapiens_hsa047271.40967843
36Central carbon metabolism in cancer_Homo sapiens_hsa052301.39985633
37Nitrogen metabolism_Homo sapiens_hsa009101.39496878
38Oocyte meiosis_Homo sapiens_hsa041141.39333250
39Butanoate metabolism_Homo sapiens_hsa006501.38382599
40Sulfur relay system_Homo sapiens_hsa041221.35731490
41Melanoma_Homo sapiens_hsa052181.34435962
42Lysine degradation_Homo sapiens_hsa003101.29521957
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28197229
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.24868291
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24213176
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.24044371
47Propanoate metabolism_Homo sapiens_hsa006401.23006867
48Arginine biosynthesis_Homo sapiens_hsa002201.21911906
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21235393
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.20774706
51Basal transcription factors_Homo sapiens_hsa030221.20460710
52Hepatitis C_Homo sapiens_hsa051601.20061928
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19343128
54Tight junction_Homo sapiens_hsa045301.18986503
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17477632
56Pentose phosphate pathway_Homo sapiens_hsa000301.17266737
57Sphingolipid metabolism_Homo sapiens_hsa006001.16979411
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.16021173
59Prolactin signaling pathway_Homo sapiens_hsa049171.15933134
60Renal cell carcinoma_Homo sapiens_hsa052111.15238948
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.13996979
62Morphine addiction_Homo sapiens_hsa050321.12352450
63Sphingolipid signaling pathway_Homo sapiens_hsa040711.07461017
64Taste transduction_Homo sapiens_hsa047421.06846808
65Type II diabetes mellitus_Homo sapiens_hsa049301.04098842
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03996992
67Glutamatergic synapse_Homo sapiens_hsa047241.03321531
68Cholinergic synapse_Homo sapiens_hsa047251.02478658
69Dorso-ventral axis formation_Homo sapiens_hsa043201.01208660
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.00205445
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99959723
72Notch signaling pathway_Homo sapiens_hsa043300.99947371
73Carbon metabolism_Homo sapiens_hsa012000.98997759
74Circadian entrainment_Homo sapiens_hsa047130.98703836
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.97743708
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97532046
77Chronic myeloid leukemia_Homo sapiens_hsa052200.97519555
78Purine metabolism_Homo sapiens_hsa002300.96171349
79Phototransduction_Homo sapiens_hsa047440.92681426
80Olfactory transduction_Homo sapiens_hsa047400.91809569
81Prostate cancer_Homo sapiens_hsa052150.90862717
82Axon guidance_Homo sapiens_hsa043600.90838193
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.90818833
84Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.90190083
85Vitamin digestion and absorption_Homo sapiens_hsa049770.88461587
86Glucagon signaling pathway_Homo sapiens_hsa049220.88336292
87Long-term potentiation_Homo sapiens_hsa047200.87578976
88Lysosome_Homo sapiens_hsa041420.87239168
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86625613
90Glycerolipid metabolism_Homo sapiens_hsa005610.86474398
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.84787450
92Folate biosynthesis_Homo sapiens_hsa007900.81915549
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.81384740
94Cardiac muscle contraction_Homo sapiens_hsa042600.79644236
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.79283321
96Inositol phosphate metabolism_Homo sapiens_hsa005620.78525290
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77044794
98Salivary secretion_Homo sapiens_hsa049700.76305888
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76027876
100Calcium signaling pathway_Homo sapiens_hsa040200.75966301
101Cell cycle_Homo sapiens_hsa041100.75894334
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.75422846
103Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72298319
104Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71840334
105Fatty acid elongation_Homo sapiens_hsa000620.70949841
106beta-Alanine metabolism_Homo sapiens_hsa004100.70311000
107Bladder cancer_Homo sapiens_hsa052190.69948285
108Fatty acid metabolism_Homo sapiens_hsa012120.67488197
109Renin secretion_Homo sapiens_hsa049240.67243397
110Long-term depression_Homo sapiens_hsa047300.67161161
111Pyruvate metabolism_Homo sapiens_hsa006200.65765269
112Amphetamine addiction_Homo sapiens_hsa050310.65660711
113Melanogenesis_Homo sapiens_hsa049160.65508503
114FoxO signaling pathway_Homo sapiens_hsa040680.64282283
115N-Glycan biosynthesis_Homo sapiens_hsa005100.62844030
116Primary bile acid biosynthesis_Homo sapiens_hsa001200.62196878
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61105934
118Insulin secretion_Homo sapiens_hsa049110.60718248
119Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58816105
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58801863
121Steroid biosynthesis_Homo sapiens_hsa001000.58453160
122Pyrimidine metabolism_Homo sapiens_hsa002400.58277494
123Oxytocin signaling pathway_Homo sapiens_hsa049210.54170087
124Colorectal cancer_Homo sapiens_hsa052100.54065456
125B cell receptor signaling pathway_Homo sapiens_hsa046620.53103605
126Hippo signaling pathway_Homo sapiens_hsa043900.52880959
127Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52095120
128Dopaminergic synapse_Homo sapiens_hsa047280.50698868
129Drug metabolism - other enzymes_Homo sapiens_hsa009830.50499645
130Arginine and proline metabolism_Homo sapiens_hsa003300.49668673
131Endocytosis_Homo sapiens_hsa041440.48638409
132Metabolic pathways_Homo sapiens_hsa011000.48032299
133Gap junction_Homo sapiens_hsa045400.47401079
134Nucleotide excision repair_Homo sapiens_hsa034200.46858996
135mTOR signaling pathway_Homo sapiens_hsa041500.46031595
136Dilated cardiomyopathy_Homo sapiens_hsa054140.45358902
137Phenylalanine metabolism_Homo sapiens_hsa003600.45214999
138T cell receptor signaling pathway_Homo sapiens_hsa046600.44339052
139Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43472255
140Oxidative phosphorylation_Homo sapiens_hsa001900.43420563
141Tryptophan metabolism_Homo sapiens_hsa003800.42173067
142Chemical carcinogenesis_Homo sapiens_hsa052040.41289642
143Vascular smooth muscle contraction_Homo sapiens_hsa042700.41157619
144Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39951590
145Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39086497
146Fanconi anemia pathway_Homo sapiens_hsa034600.39040667
147Serotonergic synapse_Homo sapiens_hsa047260.38477248
148Bile secretion_Homo sapiens_hsa049760.36991716
149Huntingtons disease_Homo sapiens_hsa050160.36880338
150Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35671080
151cAMP signaling pathway_Homo sapiens_hsa040240.35116427
152Vibrio cholerae infection_Homo sapiens_hsa051100.33839493
153Epstein-Barr virus infection_Homo sapiens_hsa051690.33435432
154ErbB signaling pathway_Homo sapiens_hsa040120.32980952
155mRNA surveillance pathway_Homo sapiens_hsa030150.31868861
156Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31377300
157Prion diseases_Homo sapiens_hsa050200.30820240
158Gastric acid secretion_Homo sapiens_hsa049710.30060592
159Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29915550
160PPAR signaling pathway_Homo sapiens_hsa033200.29050695

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »