BCAS4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.56633161
2DNA deamination (GO:0045006)5.43898860
3L-fucose catabolic process (GO:0042355)4.33787903
4fucose catabolic process (GO:0019317)4.33787903
5L-fucose metabolic process (GO:0042354)4.33787903
6indole-containing compound catabolic process (GO:0042436)3.89679969
7indolalkylamine catabolic process (GO:0046218)3.89679969
8tryptophan catabolic process (GO:0006569)3.89679969
9response to pheromone (GO:0019236)3.87313487
10kynurenine metabolic process (GO:0070189)3.76104973
11indolalkylamine metabolic process (GO:0006586)3.69105849
12cytidine metabolic process (GO:0046087)3.66879814
13cytidine catabolic process (GO:0006216)3.66879814
14cytidine deamination (GO:0009972)3.66879814
15negative regulation of telomere maintenance (GO:0032205)3.58647770
16regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.52528843
17detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.44945607
18tryptophan metabolic process (GO:0006568)3.41987727
19mitochondrial respiratory chain complex I assembly (GO:0032981)3.39003681
20NADH dehydrogenase complex assembly (GO:0010257)3.39003681
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.39003681
22protein complex biogenesis (GO:0070271)3.32997662
23detection of light stimulus involved in sensory perception (GO:0050962)3.32048200
24detection of light stimulus involved in visual perception (GO:0050908)3.32048200
25negative regulation of mast cell activation (GO:0033004)3.27050727
26pyrimidine ribonucleoside catabolic process (GO:0046133)3.26482701
27sulfation (GO:0051923)3.26387800
28cellular ketone body metabolic process (GO:0046950)3.23920412
29platelet dense granule organization (GO:0060155)3.23708376
30positive regulation of defense response to virus by host (GO:0002230)3.21623702
31protein import into peroxisome matrix (GO:0016558)3.14619265
32mitochondrial respiratory chain complex assembly (GO:0033108)3.10436376
33epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.08228088
34rRNA catabolic process (GO:0016075)3.00108875
35multicellular organism reproduction (GO:0032504)2.95214314
36indole-containing compound metabolic process (GO:0042430)2.92578896
37gamma-aminobutyric acid transport (GO:0015812)2.92190411
38amine catabolic process (GO:0009310)2.90311515
39cellular biogenic amine catabolic process (GO:0042402)2.90311515
40ketone body metabolic process (GO:1902224)2.89276652
41preassembly of GPI anchor in ER membrane (GO:0016254)2.88578282
42neural tube formation (GO:0001841)2.86928702
43respiratory chain complex IV assembly (GO:0008535)2.83610073
44piRNA metabolic process (GO:0034587)2.80652434
45regulation of action potential (GO:0098900)2.79269864
46regulation of hippo signaling (GO:0035330)2.77739071
47negative regulation of synaptic transmission, GABAergic (GO:0032229)2.76388868
48rhodopsin mediated signaling pathway (GO:0016056)2.75339847
49regulation of rhodopsin mediated signaling pathway (GO:0022400)2.73724129
50axoneme assembly (GO:0035082)2.73468522
51neuronal action potential (GO:0019228)2.73303134
52protein K11-linked deubiquitination (GO:0035871)2.72665131
53DNA demethylation (GO:0080111)2.69401140
54mannosylation (GO:0097502)2.68563696
55water-soluble vitamin biosynthetic process (GO:0042364)2.64900919
56primary amino compound metabolic process (GO:1901160)2.63789322
57cytochrome complex assembly (GO:0017004)2.63017031
58ubiquinone biosynthetic process (GO:0006744)2.60619548
59epithelial cilium movement (GO:0003351)2.58897548
60cilium or flagellum-dependent cell motility (GO:0001539)2.57608935
61behavioral response to ethanol (GO:0048149)2.57516274
62RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.55608624
63protein polyglutamylation (GO:0018095)2.55527023
64reciprocal meiotic recombination (GO:0007131)2.55496920
65reciprocal DNA recombination (GO:0035825)2.55496920
66regulation of posttranscriptional gene silencing (GO:0060147)2.54689820
67regulation of gene silencing by miRNA (GO:0060964)2.54689820
68regulation of gene silencing by RNA (GO:0060966)2.54689820
69NAD biosynthetic process (GO:0009435)2.54407471
70reflex (GO:0060004)2.52601879
71recombinational repair (GO:0000725)2.52166015
72retinal cone cell development (GO:0046549)2.50818237
73cornea development in camera-type eye (GO:0061303)2.50577421
74positive regulation of fatty acid transport (GO:2000193)2.49937149
75double-strand break repair via homologous recombination (GO:0000724)2.49876347
76regulation of nuclear cell cycle DNA replication (GO:0033262)2.48572363
77nonmotile primary cilium assembly (GO:0035058)2.48214688
78transmission of nerve impulse (GO:0019226)2.45975214
79serotonin metabolic process (GO:0042428)2.45297937
80tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.43900274
81RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.43900274
82adaptation of signaling pathway (GO:0023058)2.42488155
83synaptic transmission, cholinergic (GO:0007271)2.40959908
84protein-cofactor linkage (GO:0018065)2.37895709
85oxidative demethylation (GO:0070989)2.37828955
86dopamine transport (GO:0015872)2.36727281
87regulation of defense response to virus by host (GO:0050691)2.36218740
88somatic diversification of immune receptors via somatic mutation (GO:0002566)2.35343204
89somatic hypermutation of immunoglobulin genes (GO:0016446)2.35343204
90ubiquinone metabolic process (GO:0006743)2.35307087
91cilium morphogenesis (GO:0060271)2.34594480
92cilium movement (GO:0003341)2.34468465
93pseudouridine synthesis (GO:0001522)2.33941426
94positive regulation of prostaglandin secretion (GO:0032308)2.32876003
95cAMP catabolic process (GO:0006198)2.32136142
96regulation of neurotransmitter uptake (GO:0051580)2.31578366
97protein localization to cilium (GO:0061512)2.30911255
98photoreceptor cell development (GO:0042461)2.30489789
99regulation of telomere maintenance (GO:0032204)2.30122818
100replication fork processing (GO:0031297)2.29473236

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.10585302
2EZH2_22144423_ChIP-Seq_EOC_Human3.27826735
3VDR_22108803_ChIP-Seq_LS180_Human3.20225292
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.88983239
5GBX2_23144817_ChIP-Seq_PC3_Human2.53852266
6NOTCH1_21737748_ChIP-Seq_TLL_Human2.42181214
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.40252631
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.25709573
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.23455059
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15998508
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.14680277
12IGF1R_20145208_ChIP-Seq_DFB_Human2.08194075
13IRF1_19129219_ChIP-ChIP_H3396_Human2.06305416
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.01966485
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.97638657
16CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96327329
17CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96057814
18EWS_26573619_Chip-Seq_HEK293_Human1.95635603
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.93899596
20ER_23166858_ChIP-Seq_MCF-7_Human1.89118310
21EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.85284390
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79720816
23TAF15_26573619_Chip-Seq_HEK293_Human1.71559396
24MYC_18940864_ChIP-ChIP_HL60_Human1.64669824
25FUS_26573619_Chip-Seq_HEK293_Human1.62886947
26TP53_22573176_ChIP-Seq_HFKS_Human1.62121036
27P300_19829295_ChIP-Seq_ESCs_Human1.56186304
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56061986
29MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.50883852
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50056352
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.46675402
32REST_21632747_ChIP-Seq_MESCs_Mouse1.45780728
33AR_21572438_ChIP-Seq_LNCaP_Human1.44228306
34BCAT_22108803_ChIP-Seq_LS180_Human1.44209142
35GATA3_21878914_ChIP-Seq_MCF-7_Human1.44152796
36FOXA1_27270436_Chip-Seq_PROSTATE_Human1.43936648
37FOXA1_25329375_ChIP-Seq_VCAP_Human1.43936648
38TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43410135
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43410135
40EST1_17652178_ChIP-ChIP_JURKAT_Human1.41282284
41STAT3_23295773_ChIP-Seq_U87_Human1.39645137
42VDR_23849224_ChIP-Seq_CD4+_Human1.36597984
43STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.36242609
44HOXB7_26014856_ChIP-Seq_BT474_Human1.30797247
45TCF4_23295773_ChIP-Seq_U87_Human1.26430285
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.25730268
47PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25719111
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25649444
49SOX2_19829295_ChIP-Seq_ESCs_Human1.23435576
50NANOG_19829295_ChIP-Seq_ESCs_Human1.23435576
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22544157
52AR_25329375_ChIP-Seq_VCAP_Human1.22273370
53CBP_20019798_ChIP-Seq_JUKART_Human1.22083920
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22083920
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20017822
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19689602
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18383674
58* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18155642
59NCOR_22424771_ChIP-Seq_293T_Human1.18034430
60EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16634659
61FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16571494
62EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.16567740
63IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15539435
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15183055
65AR_20517297_ChIP-Seq_VCAP_Human1.14685629
66EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13356472
67GATA3_26560356_Chip-Seq_TH2_Human1.11878980
68PRDM14_20953172_ChIP-Seq_ESCs_Human1.09671321
69ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09212060
70IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.09065014
71CBX2_27304074_Chip-Seq_ESCs_Mouse1.08323098
72TCF4_22108803_ChIP-Seq_LS180_Human1.07696254
73NANOG_20526341_ChIP-Seq_ESCs_Human1.07690593
74ERA_21632823_ChIP-Seq_H3396_Human1.07087183
75PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06882500
76RNF2_27304074_Chip-Seq_NSC_Mouse1.06020880
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.05397371
78TAF2_19829295_ChIP-Seq_ESCs_Human1.05081678
79SMAD4_21799915_ChIP-Seq_A2780_Human1.04641637
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03656597
81PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03011751
82MYC_19829295_ChIP-Seq_ESCs_Human1.02254346
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01493506
84LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01230812
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00943442
86SALL1_21062744_ChIP-ChIP_HESCs_Human1.00823224
87SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00620604
88FLI1_21867929_ChIP-Seq_TH2_Mouse0.99297593
89RUNX2_22187159_ChIP-Seq_PCA_Human0.97615764
90DROSHA_22980978_ChIP-Seq_HELA_Human0.97480140
91SMAD4_21741376_ChIP-Seq_EPCs_Human0.97336008
92PIAS1_25552417_ChIP-Seq_VCAP_Human0.96294252
93TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95438299
94NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.95049174
95EZH2_27294783_Chip-Seq_NPCs_Mouse0.94988945
96TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94300329
97RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.92885264
98REST_18959480_ChIP-ChIP_MESCs_Mouse0.92641010
99KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.91636892
100KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90887219

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation2.60798056
2MP0005645_abnormal_hypothalamus_physiol2.58822345
3MP0001968_abnormal_touch/_nociception2.54667934
4MP0002653_abnormal_ependyma_morphology2.40650657
5MP0009046_muscle_twitch2.36711741
6MP0008872_abnormal_physiological_respon2.34344379
7MP0003195_calcinosis2.29858510
8MP0005551_abnormal_eye_electrophysiolog2.29362660
9MP0001986_abnormal_taste_sensitivity2.25459487
10MP0000569_abnormal_digit_pigmentation2.22671394
11MP0005671_abnormal_response_to2.08589381
12MP0002102_abnormal_ear_morphology2.07453451
13MP0002736_abnormal_nociception_after2.01474534
14MP0009745_abnormal_behavioral_response2.01324086
15MP0003787_abnormal_imprinting1.89676062
16MP0004043_abnormal_pH_regulation1.86684045
17MP0000427_abnormal_hair_cycle1.86439253
18MP0000372_irregular_coat_pigmentation1.80021353
19MP0003646_muscle_fatigue1.79138695
20MP0004142_abnormal_muscle_tone1.76664239
21MP0006292_abnormal_olfactory_placode1.70573857
22MP0005646_abnormal_pituitary_gland1.68608142
23MP0003136_yellow_coat_color1.64610045
24MP0008875_abnormal_xenobiotic_pharmacok1.63803077
25MP0006072_abnormal_retinal_apoptosis1.63737952
26MP0003880_abnormal_central_pattern1.61374733
27MP0002837_dystrophic_cardiac_calcinosis1.60274621
28MP0001501_abnormal_sleep_pattern1.56168492
29MP0002876_abnormal_thyroid_physiology1.55458943
30MP0002272_abnormal_nervous_system1.55376021
31MP0004147_increased_porphyrin_level1.51316224
32MP0002735_abnormal_chemical_nociception1.51055246
33MP0000631_abnormal_neuroendocrine_gland1.49765139
34MP0005253_abnormal_eye_physiology1.43469111
35MP0000685_abnormal_immune_system1.43444513
36MP0005174_abnormal_tail_pigmentation1.42705817
37MP0004885_abnormal_endolymph1.41898828
38MP0001800_abnormal_humoral_immune1.41647205
39MP0005075_abnormal_melanosome_morpholog1.39900256
40MP0002638_abnormal_pupillary_reflex1.35266313
41MP0002064_seizures1.33944242
42MP0001873_stomach_inflammation1.33490220
43MP0001919_abnormal_reproductive_system1.31771164
44MP0002572_abnormal_emotion/affect_behav1.31167186
45MP0004133_heterotaxia1.27946497
46MP0002733_abnormal_thermal_nociception1.26630154
47MP0001485_abnormal_pinna_reflex1.25663880
48MP0005389_reproductive_system_phenotype1.25386189
49MP0001486_abnormal_startle_reflex1.24812619
50MP0004742_abnormal_vestibular_system1.23955492
51MP0002163_abnormal_gland_morphology1.21557456
52MP0006276_abnormal_autonomic_nervous1.21275945
53MP0002928_abnormal_bile_duct1.20886272
54MP0002138_abnormal_hepatobiliary_system1.19574400
55MP0002938_white_spotting1.19223509
56MP0001970_abnormal_pain_threshold1.17020484
57MP0003011_delayed_dark_adaptation1.15950561
58MP0002557_abnormal_social/conspecific_i1.12955814
59MP0005423_abnormal_somatic_nervous1.12525491
60MP0002067_abnormal_sensory_capabilities1.11659469
61MP0004924_abnormal_behavior1.09290629
62MP0005386_behavior/neurological_phenoty1.09290629
63MP0003635_abnormal_synaptic_transmissio1.09138201
64MP0002160_abnormal_reproductive_system1.08943078
65MP0005084_abnormal_gallbladder_morpholo1.08237480
66MP0001790_abnormal_immune_system1.08147964
67MP0005387_immune_system_phenotype1.08147964
68MP0005310_abnormal_salivary_gland1.07941191
69MP0010386_abnormal_urinary_bladder1.07585742
70MP0002095_abnormal_skin_pigmentation1.06482677
71MP0000383_abnormal_hair_follicle1.06193590
72MP0001905_abnormal_dopamine_level1.04631180
73MP0002693_abnormal_pancreas_physiology1.04169620
74MP0002063_abnormal_learning/memory/cond1.03661605
75MP0005379_endocrine/exocrine_gland_phen1.02731923
76MP0004145_abnormal_muscle_electrophysio1.01563521
77MP0008961_abnormal_basal_metabolism1.00727113
78MP0001984_abnormal_olfaction0.95886274
79MP0003763_abnormal_thymus_physiology0.95878634
80MP0002277_abnormal_respiratory_mucosa0.91739556
81MP0002234_abnormal_pharynx_morphology0.91717135
82MP0008995_early_reproductive_senescence0.91216796
83MP0001529_abnormal_vocalization0.90801777
84MP0002723_abnormal_immune_serum0.90622242
85MP0003718_maternal_effect0.90262259
86MP0003878_abnormal_ear_physiology0.86085345
87MP0005377_hearing/vestibular/ear_phenot0.86085345
88MP0003283_abnormal_digestive_organ0.85638163
89MP0001835_abnormal_antigen_presentation0.85038690
90MP0005195_abnormal_posterior_eye0.81591522
91MP0002752_abnormal_somatic_nervous0.81588862
92MP0005410_abnormal_fertilization0.80356572
93MP0002734_abnormal_mechanical_nocicepti0.80284857
94MP0003698_abnormal_male_reproductive0.79841526
95MP0008058_abnormal_DNA_repair0.79376088
96MP0002452_abnormal_antigen_presenting0.78481153
97MP0002751_abnormal_autonomic_nervous0.77957071
98MP0002254_reproductive_system_inflammat0.77888857
99MP0004130_abnormal_muscle_cell0.77678291
100MP0000026_abnormal_inner_ear0.77209098

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.63848266
2Congenital stationary night blindness (HP:0007642)4.07776487
3Molar tooth sign on MRI (HP:0002419)4.01253948
4Abnormality of midbrain morphology (HP:0002418)4.01253948
5Pancreatic fibrosis (HP:0100732)3.93255497
6True hermaphroditism (HP:0010459)3.84703153
7Nephronophthisis (HP:0000090)3.30802858
8Type II lissencephaly (HP:0007260)3.26212656
9Attenuation of retinal blood vessels (HP:0007843)3.24157348
10Inability to walk (HP:0002540)3.00060027
11Abnormality of the renal cortex (HP:0011035)2.98413465
12Abnormality of alanine metabolism (HP:0010916)2.97361519
13Hyperalaninemia (HP:0003348)2.97361519
14Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.97361519
15Chronic hepatic failure (HP:0100626)2.92057961
16Concave nail (HP:0001598)2.90520725
17Hyperventilation (HP:0002883)2.90320648
18Abnormality of the renal medulla (HP:0100957)2.86162119
19Gaze-evoked nystagmus (HP:0000640)2.71832713
20Medial flaring of the eyebrow (HP:0010747)2.70295069
21Cystic liver disease (HP:0006706)2.69022884
22Pendular nystagmus (HP:0012043)2.65855833
23Progressive cerebellar ataxia (HP:0002073)2.65326628
24Abnormal rod and cone electroretinograms (HP:0008323)2.63228859
25Genetic anticipation (HP:0003743)2.62985933
26Large for gestational age (HP:0001520)2.56299448
27IgG deficiency (HP:0004315)2.52940020
28Congenital, generalized hypertrichosis (HP:0004540)2.52742881
29Furrowed tongue (HP:0000221)2.48456248
30Stomach cancer (HP:0012126)2.46332279
31Progressive inability to walk (HP:0002505)2.42983446
32Clumsiness (HP:0002312)2.42799999
33Abolished electroretinogram (ERG) (HP:0000550)2.42585970
34Tubular atrophy (HP:0000092)2.40264112
35Lissencephaly (HP:0001339)2.40187669
36Increased corneal curvature (HP:0100692)2.32418134
37Keratoconus (HP:0000563)2.32418134
38Absent rod-and cone-mediated responses on ERG (HP:0007688)2.31845191
39Cerebellar dysplasia (HP:0007033)2.30360219
40Sclerocornea (HP:0000647)2.30348367
41Protruding tongue (HP:0010808)2.29087937
42Renal cortical cysts (HP:0000803)2.29085096
43Patellar aplasia (HP:0006443)2.28286352
44Decreased central vision (HP:0007663)2.27870350
45Abnormality of the pons (HP:0007361)2.19824179
46Aplasia/Hypoplasia of the patella (HP:0006498)2.19562358
47Hypoplasia of the pons (HP:0012110)2.18999895
48Gait imbalance (HP:0002141)2.18670481
49Aplasia/Hypoplasia of the tongue (HP:0010295)2.10260708
50Broad-based gait (HP:0002136)2.09216554
51Congenital primary aphakia (HP:0007707)2.08587183
52Anencephaly (HP:0002323)2.06810288
53Abnormal drinking behavior (HP:0030082)2.06793965
54Polydipsia (HP:0001959)2.06793965
55Severe muscular hypotonia (HP:0006829)2.03473604
56Absent/shortened dynein arms (HP:0200106)2.02636088
57Dynein arm defect of respiratory motile cilia (HP:0012255)2.02636088
58Birth length less than 3rd percentile (HP:0003561)2.02298660
59Abnormal number of erythroid precursors (HP:0012131)2.00140801
60Febrile seizures (HP:0002373)1.98062034
61Nephrogenic diabetes insipidus (HP:0009806)1.97113673
62Aplasia/Hypoplasia of the tibia (HP:0005772)1.95246974
63Male pseudohermaphroditism (HP:0000037)1.94224904
64Congenital hepatic fibrosis (HP:0002612)1.93576437
65Mitochondrial inheritance (HP:0001427)1.93459250
66Agammaglobulinemia (HP:0004432)1.86025830
67Postaxial foot polydactyly (HP:0001830)1.83369847
68Fair hair (HP:0002286)1.82675389
69Recurrent sinusitis (HP:0011108)1.82337650
70Decreased electroretinogram (ERG) amplitude (HP:0000654)1.81716895
71Increased CSF lactate (HP:0002490)1.80850911
72Bony spicule pigmentary retinopathy (HP:0007737)1.80727673
733-Methylglutaconic aciduria (HP:0003535)1.80094651
74Genital tract atresia (HP:0001827)1.78082885
75Chorioretinal atrophy (HP:0000533)1.77332537
76Abnormal respiratory epithelium morphology (HP:0012253)1.76896447
77Abnormal respiratory motile cilium morphology (HP:0005938)1.76896447
78Abnormal biliary tract physiology (HP:0012439)1.74989465
79Bile duct proliferation (HP:0001408)1.74989465
80Vaginal atresia (HP:0000148)1.74594372
81Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.74320143
82Panhypogammaglobulinemia (HP:0003139)1.73922474
83Ketosis (HP:0001946)1.73601538
84Polyuria (HP:0000103)1.73591805
85Abnormal ciliary motility (HP:0012262)1.72992186
86Abnormal albumin level (HP:0012116)1.72173845
87Hypoalbuminemia (HP:0003073)1.72173845
88Abnormal delayed hypersensitivity skin test (HP:0002963)1.71586642
89Optic disc pallor (HP:0000543)1.71537712
90Recurrent bronchitis (HP:0002837)1.71390390
91Abnormality of B cell number (HP:0010975)1.70366702
92Focal motor seizures (HP:0011153)1.69611496
93Colon cancer (HP:0003003)1.69203468
94Acute necrotizing encephalopathy (HP:0006965)1.68904260
95Ketoacidosis (HP:0001993)1.67169387
96Conical tooth (HP:0000698)1.64960757
97Methylmalonic aciduria (HP:0012120)1.64162531
98Optic nerve hypoplasia (HP:0000609)1.63425929
99Thyroiditis (HP:0100646)1.62965482
100Hemiparesis (HP:0001269)1.62797519

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.88038649
2ADRBK23.48031408
3ZAK3.27313066
4TLK13.27258473
5BMPR1B2.98159400
6TAOK32.88305857
7INSRR2.75655071
8GRK12.62050407
9TXK2.57730469
10ACVR1B2.26608909
11NUAK12.24120622
12MAP4K22.10785980
13VRK21.87763196
14MAP4K11.78924517
15VRK11.75096423
16WNK41.63412020
17WNK31.63314520
18MAPK131.60396665
19PINK11.56148265
20MUSK1.50582748
21DAPK21.47750179
22OXSR11.46857172
23MAPKAPK31.45552892
24CASK1.27377954
25ADRBK11.22373384
26SYK1.18820164
27BCKDK1.16029367
28IKBKB1.12875271
29CAMKK21.09419631
30STK391.07626895
31NTRK31.05635545
32PASK1.02354459
33MAP3K40.99014412
34PRKCQ0.98005076
35TNK20.95701857
36TGFBR10.94756001
37GRK60.91517640
38CAMKK10.91098445
39RPS6KA50.90342561
40ITK0.86929416
41KIT0.85815526
42PAK30.85510118
43SIK20.84226233
44TEC0.78320412
45BRSK20.76361599
46MST40.75092465
47CHUK0.74920650
48MAPK150.74707939
49IKBKE0.74058379
50MKNK20.72828288
51PTK2B0.72758768
52PRKCG0.72272072
53WEE10.71626138
54MAP2K20.70423894
55DYRK20.64415985
56TAF10.63992390
57PRKCE0.63391885
58MAP2K70.63345653
59TRIM280.62824833
60PRKCI0.61939612
61BLK0.61720213
62LYN0.61614923
63BTK0.59269647
64GRK50.58231866
65CSF1R0.54382873
66PNCK0.53983827
67PIK3CA0.53424166
68PKN10.53385512
69IRAK40.52797050
70PRKCH0.50885257
71KDR0.50275457
72EPHA40.50254799
73CSNK1G20.49813530
74TNIK0.49708416
75CSNK1A1L0.48074617
76NME10.47792504
77CSNK1G30.47313193
78CAMK10.46493837
79CHEK20.46326956
80FGFR20.46192361
81MAPKAPK50.45884142
82LCK0.45298137
83CSNK1G10.44584106
84STK110.44388420
85MAP2K60.44357685
86CAMK2A0.41353740
87STK38L0.40250136
88NEK20.38949382
89CSNK1A10.38728383
90ATR0.37657585
91PIM10.36852824
92PHKG10.36449206
93PHKG20.36449206
94PRKACA0.35092779
95MARK10.34805630
96MAP2K10.33268081
97STK30.32397183
98PLK20.31387058
99PRKCZ0.31162961
100CSNK1D0.30826706

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.03253783
2Phototransduction_Homo sapiens_hsa047442.82066602
3Intestinal immune network for IgA production_Homo sapiens_hsa046722.69465983
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.21833980
5Nitrogen metabolism_Homo sapiens_hsa009102.18785283
6Homologous recombination_Homo sapiens_hsa034402.18184587
7Linoleic acid metabolism_Homo sapiens_hsa005912.11231397
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.10702202
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.08845089
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.99584572
11Butanoate metabolism_Homo sapiens_hsa006501.97754611
12Selenocompound metabolism_Homo sapiens_hsa004501.96886098
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.95692314
14Asthma_Homo sapiens_hsa053101.95273591
15Graft-versus-host disease_Homo sapiens_hsa053321.94449967
16Nicotine addiction_Homo sapiens_hsa050331.94178317
17Oxidative phosphorylation_Homo sapiens_hsa001901.93682223
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.93402205
19Allograft rejection_Homo sapiens_hsa053301.92132552
20Autoimmune thyroid disease_Homo sapiens_hsa053201.89355611
21RNA polymerase_Homo sapiens_hsa030201.89098238
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.73824368
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.72236995
24Type I diabetes mellitus_Homo sapiens_hsa049401.66848033
25Fanconi anemia pathway_Homo sapiens_hsa034601.56672124
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.50807336
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50720857
28Parkinsons disease_Homo sapiens_hsa050121.46048034
29Taste transduction_Homo sapiens_hsa047421.45164211
30Systemic lupus erythematosus_Homo sapiens_hsa053221.40897427
31Morphine addiction_Homo sapiens_hsa050321.39866410
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.37683595
33Caffeine metabolism_Homo sapiens_hsa002321.36071522
34Tryptophan metabolism_Homo sapiens_hsa003801.33835990
35ABC transporters_Homo sapiens_hsa020101.33436855
36Ether lipid metabolism_Homo sapiens_hsa005651.30133800
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.25115060
38Basal transcription factors_Homo sapiens_hsa030221.25099811
39Olfactory transduction_Homo sapiens_hsa047401.24678672
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.21214428
41RNA degradation_Homo sapiens_hsa030181.19382208
42Huntingtons disease_Homo sapiens_hsa050161.01151212
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00258859
44Peroxisome_Homo sapiens_hsa041460.94396451
45Ribosome_Homo sapiens_hsa030100.93842470
46Cardiac muscle contraction_Homo sapiens_hsa042600.93616667
47Alzheimers disease_Homo sapiens_hsa050100.93348001
48Antigen processing and presentation_Homo sapiens_hsa046120.91959073
49Insulin secretion_Homo sapiens_hsa049110.91558939
50GABAergic synapse_Homo sapiens_hsa047270.91389490
51Sulfur relay system_Homo sapiens_hsa041220.90806668
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.90783620
53Serotonergic synapse_Homo sapiens_hsa047260.90158963
54Circadian entrainment_Homo sapiens_hsa047130.89125168
55Alcoholism_Homo sapiens_hsa050340.87299688
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.85901618
57Protein export_Homo sapiens_hsa030600.85702043
58Regulation of autophagy_Homo sapiens_hsa041400.84529695
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.82234634
60Calcium signaling pathway_Homo sapiens_hsa040200.78773333
61Glutamatergic synapse_Homo sapiens_hsa047240.78657340
62One carbon pool by folate_Homo sapiens_hsa006700.78420910
63Chemical carcinogenesis_Homo sapiens_hsa052040.72723358
64Purine metabolism_Homo sapiens_hsa002300.71851701
65Ovarian steroidogenesis_Homo sapiens_hsa049130.70616187
66Arachidonic acid metabolism_Homo sapiens_hsa005900.70488515
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69796226
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.67874319
69Pyrimidine metabolism_Homo sapiens_hsa002400.67658734
70Salivary secretion_Homo sapiens_hsa049700.65478775
71Hematopoietic cell lineage_Homo sapiens_hsa046400.59777751
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59407151
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58484194
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57888499
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56551597
76Vitamin digestion and absorption_Homo sapiens_hsa049770.52979786
77Cholinergic synapse_Homo sapiens_hsa047250.52750167
78Glycerolipid metabolism_Homo sapiens_hsa005610.52385546
79T cell receptor signaling pathway_Homo sapiens_hsa046600.52280304
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51819655
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51402523
82Retinol metabolism_Homo sapiens_hsa008300.48987512
83Rheumatoid arthritis_Homo sapiens_hsa053230.48505287
84Proteasome_Homo sapiens_hsa030500.46944285
85Dopaminergic synapse_Homo sapiens_hsa047280.45976143
86Propanoate metabolism_Homo sapiens_hsa006400.44822019
87Amphetamine addiction_Homo sapiens_hsa050310.43516456
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.41878678
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41701284
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.40770197
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39670287
92Nucleotide excision repair_Homo sapiens_hsa034200.36851493
93cAMP signaling pathway_Homo sapiens_hsa040240.36760729
94Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.35771387
95B cell receptor signaling pathway_Homo sapiens_hsa046620.35638069
96Metabolic pathways_Homo sapiens_hsa011000.35122139
97Oxytocin signaling pathway_Homo sapiens_hsa049210.32301773
98Base excision repair_Homo sapiens_hsa034100.30329059
99Cocaine addiction_Homo sapiens_hsa050300.29447878
100Sulfur metabolism_Homo sapiens_hsa009200.28494845

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