BCAT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the reversible transamination of branched-chain alpha-keto acids to branched-chain L-amino acids essential for cell growth. Two different clinical disorders have been attributed to a defect of branched-chain amino acid transamination: hypervalinemia and hyperleucine-isoleucinemia. As there is also a gene encoding a mitochondrial form of this enzyme, mutations in either gene may contribute to these disorders. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromatin remodeling at centromere (GO:0031055)5.14719241
2CENP-A containing nucleosome assembly (GO:0034080)4.97892123
3establishment of integrated proviral latency (GO:0075713)4.67715260
4histone exchange (GO:0043486)4.48139272
5nucleobase biosynthetic process (GO:0046112)4.44618366
6purine nucleobase biosynthetic process (GO:0009113)4.41854070
7ribosome assembly (GO:0042255)4.35212626
8negative regulation of DNA-dependent DNA replication (GO:2000104)4.26517762
9DNA double-strand break processing (GO:0000729)4.24689054
10L-serine metabolic process (GO:0006563)4.22508318
11histone arginine methylation (GO:0034969)4.11191938
12DNA replication-independent nucleosome organization (GO:0034724)4.10932722
13DNA replication-independent nucleosome assembly (GO:0006336)4.10932722
14ribosome biogenesis (GO:0042254)4.04052862
15mitotic metaphase plate congression (GO:0007080)3.93431837
16regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.91887900
17regulation of mitotic spindle checkpoint (GO:1903504)3.91887900
18peptidyl-arginine omega-N-methylation (GO:0035247)3.85172703
19regulation of centriole replication (GO:0046599)3.84259265
20regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.81165147
21DNA replication-dependent nucleosome organization (GO:0034723)3.77808881
22DNA replication-dependent nucleosome assembly (GO:0006335)3.77808881
23DNA ligation (GO:0006266)3.77352809
24formation of translation preinitiation complex (GO:0001731)3.76318614
25establishment of protein localization to mitochondrial membrane (GO:0090151)3.74404608
26mitotic G2/M transition checkpoint (GO:0044818)3.65627464
27regulation of translational termination (GO:0006449)3.64521304
28regulation of sister chromatid segregation (GO:0033045)3.63420524
29regulation of mitotic sister chromatid separation (GO:0010965)3.63420524
30regulation of gene silencing by RNA (GO:0060966)3.62783082
31regulation of posttranscriptional gene silencing (GO:0060147)3.62783082
32regulation of gene silencing by miRNA (GO:0060964)3.62783082
33IMP biosynthetic process (GO:0006188)3.58176943
34kinetochore organization (GO:0051383)3.57781280
35mitotic sister chromatid cohesion (GO:0007064)3.56918562
36establishment of chromosome localization (GO:0051303)3.56138693
37nuclear pore organization (GO:0006999)3.55981156
38double-strand break repair via nonhomologous end joining (GO:0006303)3.55389283
39non-recombinational repair (GO:0000726)3.55389283
40regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.54038656
41negative regulation of DNA recombination (GO:0045910)3.51879347
42response to X-ray (GO:0010165)3.50924011
43DNA replication initiation (GO:0006270)3.50731787
44protein localization to kinetochore (GO:0034501)3.50365680
45mitotic sister chromatid segregation (GO:0000070)3.49301590
46peptidyl-arginine methylation (GO:0018216)3.45545490
47peptidyl-arginine N-methylation (GO:0035246)3.45545490
48DNA strand renaturation (GO:0000733)3.45086156
49establishment of viral latency (GO:0019043)3.44095301
50heterochromatin organization (GO:0070828)3.34158134
51mitotic nuclear envelope disassembly (GO:0007077)3.33439361
52DNA replication checkpoint (GO:0000076)3.30640175
53replication fork processing (GO:0031297)3.30525194
54telomere maintenance via semi-conservative replication (GO:0032201)3.28519549
55regulation of spindle organization (GO:0090224)3.27013068
56ATP-dependent chromatin remodeling (GO:0043044)3.26562997
57somatic diversification of immune receptors via somatic mutation (GO:0002566)3.25710051
58somatic hypermutation of immunoglobulin genes (GO:0016446)3.25710051
59maturation of SSU-rRNA (GO:0030490)3.24185271
60telomere maintenance via telomerase (GO:0007004)3.24110577
61ribonucleoprotein complex biogenesis (GO:0022613)3.23028356
62spliceosomal snRNP assembly (GO:0000387)3.22044210
63cullin deneddylation (GO:0010388)3.20651492
64nuclear pore complex assembly (GO:0051292)3.19302991
65negative regulation of mitosis (GO:0045839)3.18881436
66membrane disassembly (GO:0030397)3.18372343
67nuclear envelope disassembly (GO:0051081)3.18372343
68mitotic recombination (GO:0006312)3.17279025
69kinetochore assembly (GO:0051382)3.15378542
70female gonad development (GO:0008585)3.11314036
71positive regulation of chromosome segregation (GO:0051984)3.08212535
72folic acid-containing compound biosynthetic process (GO:0009396)3.07342349
73rRNA modification (GO:0000154)3.06159841
74DNA topological change (GO:0006265)3.05840760
75maturation of 5.8S rRNA (GO:0000460)3.04216576
76pore complex assembly (GO:0046931)3.04011684
77metaphase plate congression (GO:0051310)3.03806941
78DNA catabolic process, exonucleolytic (GO:0000738)3.03087081
79DNA unwinding involved in DNA replication (GO:0006268)3.02389449
80anterior/posterior axis specification, embryo (GO:0008595)3.02334529
81mitotic G2 DNA damage checkpoint (GO:0007095)3.01534652
82maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.00382734
83ventricular cardiac muscle cell development (GO:0055015)2.99074891
84paraxial mesoderm development (GO:0048339)2.98580377
85sister chromatid segregation (GO:0000819)2.98567004
86telomere maintenance via recombination (GO:0000722)2.96973059
87RNA-dependent DNA replication (GO:0006278)2.96502935
88regulation of centrosome cycle (GO:0046605)2.95531150
89IMP metabolic process (GO:0046040)2.95444269
90negative regulation of fibroblast apoptotic process (GO:2000270)2.95282169
91rRNA processing (GO:0006364)2.94297719
92anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.93873103
93regulation of mitotic spindle organization (GO:0060236)2.93477794
94DNA strand elongation involved in DNA replication (GO:0006271)2.92478496
95somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.89430167
96isotype switching (GO:0045190)2.89430167
97somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.89430167
98negative regulation of chromosome segregation (GO:0051985)2.88790129
99transcription from RNA polymerase I promoter (GO:0006360)2.87882156
100negative regulation of nuclear division (GO:0051784)2.87387891
101positive regulation of SMAD protein import into nucleus (GO:0060391)2.85359824
102mitotic spindle checkpoint (GO:0071174)2.85305403
103DNA damage response, detection of DNA damage (GO:0042769)2.84553786
104rRNA metabolic process (GO:0016072)2.83576234
105regulation of helicase activity (GO:0051095)2.82689530
106spindle checkpoint (GO:0031577)2.82466855
107pre-miRNA processing (GO:0031054)2.81997278
108tRNA aminoacylation for protein translation (GO:0006418)2.81466030
109regulation of telomere maintenance via telomerase (GO:0032210)2.81362003
110negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.80823019
111protein deneddylation (GO:0000338)2.80772218
112transcription elongation from RNA polymerase I promoter (GO:0006362)2.80649125
113determination of adult lifespan (GO:0008340)2.79587237
114negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.78955608
115negative regulation of sister chromatid segregation (GO:0033046)2.78955608
116negative regulation of mitotic sister chromatid separation (GO:2000816)2.78955608
117negative regulation of mitotic sister chromatid segregation (GO:0033048)2.78955608
118negative regulation of DNA repair (GO:0045738)2.78291912
119telomere maintenance via telomere lengthening (GO:0010833)2.78193062
120regulation of chromosome segregation (GO:0051983)2.78052547
121mitotic spindle assembly checkpoint (GO:0007094)2.76567103
122regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.76355767
123folic acid metabolic process (GO:0046655)2.75663356
124positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.74866496
125proteasome assembly (GO:0043248)2.74630829
126histone H4-K12 acetylation (GO:0043983)2.74484495
127regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.73656012
128regulation of translation in response to stress (GO:0043555)2.73580610
129transcription elongation from RNA polymerase III promoter (GO:0006385)2.73468497
130termination of RNA polymerase III transcription (GO:0006386)2.73468497
131DNA strand elongation (GO:0022616)2.72398138
132spindle assembly checkpoint (GO:0071173)2.71585396
133termination of RNA polymerase I transcription (GO:0006363)2.71557341
134regulation of nuclear cell cycle DNA replication (GO:0033262)2.71545166
135lung-associated mesenchyme development (GO:0060484)2.70695322
136amino acid activation (GO:0043038)2.70436932
137tRNA aminoacylation (GO:0043039)2.70436932
138negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.69990918
139transcription initiation from RNA polymerase I promoter (GO:0006361)2.69225966
1407-methylguanosine mRNA capping (GO:0006370)2.69101411
141protein complex localization (GO:0031503)2.68881852
142chaperone-mediated protein complex assembly (GO:0051131)2.68685291
143blastocyst development (GO:0001824)2.67589578
144negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.67310602
145ribosomal large subunit biogenesis (GO:0042273)2.64537445
146spindle assembly involved in mitosis (GO:0090307)2.64026261
147protein K6-linked ubiquitination (GO:0085020)2.62763931
148protein localization to chromosome, centromeric region (GO:0071459)2.62508189
1497-methylguanosine RNA capping (GO:0009452)2.60552093
150RNA capping (GO:0036260)2.60552093
151regulation of mitotic metaphase/anaphase transition (GO:0030071)2.60120841
152spliceosomal complex assembly (GO:0000245)2.60102948
153negative regulation of androgen receptor signaling pathway (GO:0060766)2.59158640
154regulation of mitotic sister chromatid segregation (GO:0033047)2.58341957

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.33754149
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.06688708
3MYC_19079543_ChIP-ChIP_MESCs_Mouse3.46149768
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.13674837
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.12770181
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.84162059
7SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.82273187
8POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.79766569
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.74025761
10NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.67569675
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.62506989
12* NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.61114331
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.55626124
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.53201018
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.53096537
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.47170543
17* NANOG_18555785_ChIP-Seq_MESCs_Mouse2.46516236
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.43876370
19KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.39808099
20KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.39808099
21KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.39808099
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.37963911
23SALL1_21062744_ChIP-ChIP_HESCs_Human2.35728587
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.32875091
25POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.30984441
26* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.28474548
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.21330039
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.14833661
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.12671618
30EWS_26573619_Chip-Seq_HEK293_Human2.12617237
31POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.12417355
32NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10226981
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09436209
34* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.08877502
35FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.08766584
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.07171283
37GABP_17652178_ChIP-ChIP_JURKAT_Human2.06881929
38XRN2_22483619_ChIP-Seq_HELA_Human2.03306940
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.02883253
40SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.02714672
41ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.99532259
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.99064709
43SOX2_18555785_ChIP-Seq_MESCs_Mouse1.96498866
44ESR1_15608294_ChIP-ChIP_MCF-7_Human1.95175412
45* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.92337242
46FUS_26573619_Chip-Seq_HEK293_Human1.90747949
47SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.89690682
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86147283
49* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.84146196
50* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.82912236
51NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.74969876
52ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.74270477
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.73789676
54WT1_19549856_ChIP-ChIP_CCG9911_Human1.72366877
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.71278024
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69056228
57AR_21909140_ChIP-Seq_LNCAP_Human1.68413661
58ZNF274_21170338_ChIP-Seq_K562_Hela1.66629915
59KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.66483396
60STAT3_1855785_ChIP-Seq_MESCs_Mouse1.64131397
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.61786488
62TTF2_22483619_ChIP-Seq_HELA_Human1.61731344
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59675615
64FLI1_27457419_Chip-Seq_LIVER_Mouse1.55971358
65* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.54877471
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53453128
67VDR_23849224_ChIP-Seq_CD4+_Human1.51861260
68NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.51405167
69HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.51045078
70* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.46363758
71P300_19829295_ChIP-Seq_ESCs_Human1.45698500
72GABP_19822575_ChIP-Seq_HepG2_Human1.43458565
73POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43097175
74* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.42279475
75VDR_22108803_ChIP-Seq_LS180_Human1.40549888
76POU5F1_16518401_ChIP-PET_MESCs_Mouse1.39896064
77TAF15_26573619_Chip-Seq_HEK293_Human1.38676863
78DCP1A_22483619_ChIP-Seq_HELA_Human1.37612839
79* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.36803072
80* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.35569592
81* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.32612783
82MYC_18940864_ChIP-ChIP_HL60_Human1.32583268
83NANOG_21062744_ChIP-ChIP_HESCs_Human1.30937777
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30259256
85SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.25608860
86KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25452986
87PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.24767146
88FOXP3_21729870_ChIP-Seq_TREG_Human1.24179494
89* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.23595632
90* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.22394947
91E2F1_21310950_ChIP-Seq_MCF-7_Human1.22228217
92KDM5A_27292631_Chip-Seq_BREAST_Human1.19630335
93SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.19261527
94PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17411595
95CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16718315
96ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15625001
97ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15545928
98HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14738511
99* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.12475918
100* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.10766388
101* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09710842
102POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08938674
103CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08689552
104* SOX2_16153702_ChIP-ChIP_HESCs_Human1.08077275
105ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07188939
106TP63_19390658_ChIP-ChIP_HaCaT_Human1.06792296
107KAP1_27257070_Chip-Seq_ESCs_Mouse1.06306399
108ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05916062
109CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.04303960
110PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02329951
111SOX17_20123909_ChIP-Seq_XEN_Mouse1.00859185
112* NANOG_16153702_ChIP-ChIP_HESCs_Human1.00209070
113IGF1R_20145208_ChIP-Seq_DFB_Human1.00075230
114* NANOG_16518401_ChIP-PET_MESCs_Mouse0.99263548
115ELK1_19687146_ChIP-ChIP_HELA_Human0.98820335
116CIITA_25753668_ChIP-Seq_RAJI_Human0.98210698
117TBX3_20139965_ChIP-Seq_ESCs_Mouse0.95866153
118RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95138749
119TBX3_20139965_ChIP-Seq_MESCs_Mouse0.94940460
120RBPJ_22232070_ChIP-Seq_NCS_Mouse0.93672901
121* SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.93242010
122PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92965458
123PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92453912
124DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92240295
125CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90533061
126ZNF263_19887448_ChIP-Seq_K562_Human0.88662689
127EZH2_27294783_Chip-Seq_NPCs_Mouse0.86445305
128GBX2_23144817_ChIP-Seq_PC3_Human0.85178303
129* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.84868833
130AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83480514
131SOX9_26525672_Chip-Seq_HEART_Mouse0.83088902
132MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.82260227
133E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.81518519
134* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.81381984

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology3.38593082
2MP0004957_abnormal_blastocyst_morpholog3.34788972
3MP0003693_abnormal_embryo_hatching3.31867760
4MP0010094_abnormal_chromosome_stability2.97086519
5MP0002653_abnormal_ependyma_morphology2.63907201
6MP0003077_abnormal_cell_cycle2.62218241
7MP0008057_abnormal_DNA_replication2.61820045
8MP0003123_paternal_imprinting2.59560183
9MP0009697_abnormal_copulation2.42119352
10MP0008932_abnormal_embryonic_tissue2.33937716
11MP0003718_maternal_effect2.25783351
12MP0006054_spinal_hemorrhage2.10060411
13MP0008058_abnormal_DNA_repair2.04734580
14MP0004133_heterotaxia2.03831010
15MP0001730_embryonic_growth_arrest2.00513249
16MP0002938_white_spotting1.99548052
17MP0002254_reproductive_system_inflammat1.97777353
18MP0003283_abnormal_digestive_organ1.92520768
19MP0001188_hyperpigmentation1.83692311
20MP0000350_abnormal_cell_proliferation1.77263218
21MP0009672_abnormal_birth_weight1.75496800
22MP0003890_abnormal_embryonic-extraembry1.73083884
23MP0004859_abnormal_synaptic_plasticity1.70537955
24MP0003121_genomic_imprinting1.63738524
25MP0003880_abnormal_central_pattern1.63367448
26MP0008877_abnormal_DNA_methylation1.63107683
27MP0001299_abnormal_eye_distance/1.62888604
28MP0003119_abnormal_digestive_system1.58672766
29MP0002084_abnormal_developmental_patter1.57862896
30MP0002085_abnormal_embryonic_tissue1.56466114
31MP0010030_abnormal_orbit_morphology1.56271916
32MP0005380_embryogenesis_phenotype1.53399864
33MP0001672_abnormal_embryogenesis/_devel1.53399864
34MP0003786_premature_aging1.49707623
35MP0008007_abnormal_cellular_replicative1.44649135
36MP0006072_abnormal_retinal_apoptosis1.43740730
37MP0001697_abnormal_embryo_size1.43453523
38MP0006292_abnormal_olfactory_placode1.43239182
39MP0005423_abnormal_somatic_nervous1.43085117
40MP0009046_muscle_twitch1.42485288
41MP0002697_abnormal_eye_size1.39254741
42MP0002233_abnormal_nose_morphology1.38085714
43MP0002102_abnormal_ear_morphology1.35944233
44MP0004272_abnormal_basement_membrane1.35933418
45MP0003315_abnormal_perineum_morphology1.35915242
46MP0005623_abnormal_meninges_morphology1.35702457
47MP0001177_atelectasis1.34752533
48MP0009703_decreased_birth_body1.33935504
49MP0008438_abnormal_cutaneous_collagen1.28478300
50MP0000516_abnormal_urinary_system1.27728311
51MP0005367_renal/urinary_system_phenotyp1.27728311
52MP0002080_prenatal_lethality1.26642429
53MP0004885_abnormal_endolymph1.26294750
54MP0000778_abnormal_nervous_system1.25972310
55MP0000049_abnormal_middle_ear1.25842705
56MP0000537_abnormal_urethra_morphology1.25761741
57MP0010352_gastrointestinal_tract_polyps1.25333020
58MP0003861_abnormal_nervous_system1.25205016
59MP0003984_embryonic_growth_retardation1.24008221
60MP0003385_abnormal_body_wall1.23465130
61MP0004197_abnormal_fetal_growth/weight/1.22603748
62MP0002088_abnormal_embryonic_growth/wei1.21065284
63MP0001529_abnormal_vocalization1.20048890
64MP0003635_abnormal_synaptic_transmissio1.19845817
65MP0005394_taste/olfaction_phenotype1.17348037
66MP0005499_abnormal_olfactory_system1.17348037
67MP0004233_abnormal_muscle_weight1.16799738
68MP0003806_abnormal_nucleotide_metabolis1.13289349
69MP0001293_anophthalmia1.12172242
70MP0004270_analgesia1.09419752
71MP0009250_abnormal_appendicular_skeleto1.09352319
72MP0003755_abnormal_palate_morphology1.07737268
73MP0002064_seizures1.07737111
74MP0003937_abnormal_limbs/digits/tail_de1.07150023
75MP0003122_maternal_imprinting1.05590390
76MP0000647_abnormal_sebaceous_gland1.05586229
77MP0004142_abnormal_muscle_tone1.04441561
78MP0001440_abnormal_grooming_behavior1.03783659
79MP0002086_abnormal_extraembryonic_tissu1.03462216
80MP0002160_abnormal_reproductive_system1.02773588
81MP0003938_abnormal_ear_development1.02408243
82MP0002734_abnormal_mechanical_nocicepti1.01643876
83MP0002090_abnormal_vision0.99310151
84MP0002063_abnormal_learning/memory/cond0.98721060
85MP0003787_abnormal_imprinting0.98400638
86MP0003941_abnormal_skin_development0.97568187
87MP0002152_abnormal_brain_morphology0.95907112
88MP0003935_abnormal_craniofacial_develop0.95639299
89MP0008260_abnormal_autophagy0.95546641
90MP0002210_abnormal_sex_determination0.95516212
91MP0002184_abnormal_innervation0.95515803
92MP0002111_abnormal_tail_morphology0.93676151
93MP0000955_abnormal_spinal_cord0.93324987
94MP0003942_abnormal_urinary_system0.92228690
95MP0001145_abnormal_male_reproductive0.92031918
96MP0003136_yellow_coat_color0.91382744
97MP0000358_abnormal_cell_content/0.91202191
98MP0010307_abnormal_tumor_latency0.89379566
99MP0002272_abnormal_nervous_system0.89312133
100MP0005551_abnormal_eye_electrophysiolog0.88326487
101MP0002092_abnormal_eye_morphology0.88021406
102MP0002572_abnormal_emotion/affect_behav0.87330003
103MP0002752_abnormal_somatic_nervous0.86482479
104MP0000428_abnormal_craniofacial_morphol0.86138156
105MP0002882_abnormal_neuron_morphology0.84990721
106MP0001486_abnormal_startle_reflex0.83376144
107MP0008789_abnormal_olfactory_epithelium0.83064594
108MP0009745_abnormal_behavioral_response0.83029291
109MP0001849_ear_inflammation0.82315416
110MP0003632_abnormal_nervous_system0.82143539
111MP0003950_abnormal_plasma_membrane0.82087314
112MP0001286_abnormal_eye_development0.81608415
113MP0005389_reproductive_system_phenotype0.80889351
114MP0005253_abnormal_eye_physiology0.80382363
115MP0002751_abnormal_autonomic_nervous0.79317997
116MP0001542_abnormal_bone_strength0.78348515
117MP0004811_abnormal_neuron_physiology0.77296881
118MP0002114_abnormal_axial_skeleton0.77178697
119MP0006035_abnormal_mitochondrial_morpho0.77148751
120MP0005395_other_phenotype0.76687487
121MP0005076_abnormal_cell_differentiation0.75473544
122MP0000313_abnormal_cell_death0.75269553
123MP0005384_cellular_phenotype0.74273950
124MP0001485_abnormal_pinna_reflex0.74110046
125MP0001119_abnormal_female_reproductive0.74003754
126MP0001915_intracranial_hemorrhage0.73899633
127MP0005391_vision/eye_phenotype0.73565026
128MP0003567_abnormal_fetal_cardiomyocyte0.73410257
129MP0000653_abnormal_sex_gland0.73004391
130MP0000579_abnormal_nail_morphology0.72551993
131MP0000762_abnormal_tongue_morphology0.72409033
132MP0000432_abnormal_head_morphology0.71672191
133MP0003705_abnormal_hypodermis_morpholog0.70273377
134MP0002081_perinatal_lethality0.70203630
135MP0005275_abnormal_skin_tensile0.68349130
136MP0001929_abnormal_gametogenesis0.65955252
137MP0005187_abnormal_penis_morphology0.65824780
138MP0002282_abnormal_trachea_morphology0.65731676
139MP0002116_abnormal_craniofacial_bone0.65272623
140MP0002736_abnormal_nociception_after0.65122290
141MP0002109_abnormal_limb_morphology0.64541266
142MP0008770_decreased_survivor_rate0.63536887

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.97866427
2Cerebral hypomyelination (HP:0006808)4.38790144
3Ependymoma (HP:0002888)3.83131989
4Birth length less than 3rd percentile (HP:0003561)3.82897663
5Breast hypoplasia (HP:0003187)3.66830483
6Abnormal lung lobation (HP:0002101)3.47799420
7Abnormality of chromosome stability (HP:0003220)3.39608191
8Carpal bone hypoplasia (HP:0001498)3.34825066
9Absent radius (HP:0003974)3.21412083
10Nephroblastoma (Wilms tumor) (HP:0002667)3.16059461
11Abnormality of the astrocytes (HP:0100707)3.13198053
12Astrocytoma (HP:0009592)3.13198053
13Embryonal renal neoplasm (HP:0011794)3.10340842
14Aplasia involving forearm bones (HP:0009822)3.08695341
15Absent forearm bone (HP:0003953)3.08695341
16Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.01046325
17Aplasia/hypoplasia of the humerus (HP:0006507)2.79535166
18Patellar aplasia (HP:0006443)2.78096370
19Rough bone trabeculation (HP:0100670)2.74118794
20Glioma (HP:0009733)2.71009728
21Aplasia/Hypoplasia of the patella (HP:0006498)2.64558199
22Abdominal situs inversus (HP:0003363)2.61282788
23Abnormality of abdominal situs (HP:0011620)2.61282788
24CNS hypomyelination (HP:0003429)2.58321607
25Abnormality of the duodenum (HP:0002246)2.56441624
26Bifid tongue (HP:0010297)2.56168692
27Impulsivity (HP:0100710)2.54623363
28Pancreatic islet-cell hyperplasia (HP:0004510)2.51075465
29Short humerus (HP:0005792)2.48628624
30Increased nuchal translucency (HP:0010880)2.47009627
31Abnormality of methionine metabolism (HP:0010901)2.46484401
32Supernumerary spleens (HP:0009799)2.42191278
33Selective tooth agenesis (HP:0001592)2.41953565
34Medulloblastoma (HP:0002885)2.39346609
35Volvulus (HP:0002580)2.37922990
36Ectopic kidney (HP:0000086)2.37729918
37Intestinal atresia (HP:0011100)2.36581580
38Spastic diplegia (HP:0001264)2.36542494
39Hypoplastic pelvis (HP:0008839)2.24014982
40Degeneration of anterior horn cells (HP:0002398)2.23400639
41Abnormality of the anterior horn cell (HP:0006802)2.23400639
42Shawl scrotum (HP:0000049)2.22982497
43Hyperglycinemia (HP:0002154)2.22350356
44Abnormality of aspartate family amino acid metabolism (HP:0010899)2.19205646
45Abnormality of the lower motor neuron (HP:0002366)2.18440450
46Atrophy/Degeneration involving motor neurons (HP:0007373)2.16922494
47Shoulder girdle muscle weakness (HP:0003547)2.16364960
48Triphalangeal thumb (HP:0001199)2.15848523
49Sloping forehead (HP:0000340)2.15538970
50Abnormality of serum amino acid levels (HP:0003112)2.14641268
51Absent septum pellucidum (HP:0001331)2.13798288
52Irregular epiphyses (HP:0010582)2.13665661
53Abnormality of the carotid arteries (HP:0005344)2.08772117
54Premature ovarian failure (HP:0008209)2.08682764
55Colon cancer (HP:0003003)2.05954036
56Abnormal number of incisors (HP:0011064)2.05651276
57Abnormality of the septum pellucidum (HP:0007375)2.05480833
58Abnormal trabecular bone morphology (HP:0100671)2.03660738
59Rhabdomyosarcoma (HP:0002859)2.03508554
60Neoplasm of the oral cavity (HP:0100649)2.03341777
61Neoplasm of the colon (HP:0100273)2.02782458
62Horseshoe kidney (HP:0000085)2.01811087
63Abnormal hair whorl (HP:0010721)2.01566681
64Postnatal microcephaly (HP:0005484)1.98231502
65Delusions (HP:0000746)1.98202884
66Breast aplasia (HP:0100783)1.96908538
67Fused cervical vertebrae (HP:0002949)1.95580172
68Aplasia/Hypoplasia involving the musculature (HP:0001460)1.95031935
69Methylmalonic acidemia (HP:0002912)1.94165592
70Amyotrophic lateral sclerosis (HP:0007354)1.93578170
71Hypoplasia of the capital femoral epiphysis (HP:0003090)1.93098587
72Myelomeningocele (HP:0002475)1.91920321
73Agnosia (HP:0010524)1.91699615
74Myelodysplasia (HP:0002863)1.90908504
75Rib fusion (HP:0000902)1.87725830
76Glossoptosis (HP:0000162)1.86561310
77Spinal muscular atrophy (HP:0007269)1.85267509
78Meckel diverticulum (HP:0002245)1.84325005
79High anterior hairline (HP:0009890)1.82789554
80Dandy-Walker malformation (HP:0001305)1.81584805
81Chromosomal breakage induced by crosslinking agents (HP:0003221)1.80530636
82Homocystinuria (HP:0002156)1.80199080
83Abnormality of homocysteine metabolism (HP:0010919)1.80199080
84Sparse lateral eyebrow (HP:0005338)1.80006542
85Abnormality of the ileum (HP:0001549)1.79690744
86Premature rupture of membranes (HP:0001788)1.79634628
87Aplasia/Hypoplasia of the breasts (HP:0010311)1.79060201
88Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79053294
89Absent thumb (HP:0009777)1.78995583
90Rectal fistula (HP:0100590)1.78831378
91Rectovaginal fistula (HP:0000143)1.78831378
92Short middle phalanx of the 5th finger (HP:0004220)1.78828156
93Bilateral microphthalmos (HP:0007633)1.77653820
94Stenosis of the external auditory canal (HP:0000402)1.77001926
95Trismus (HP:0000211)1.75954303
96Esophageal atresia (HP:0002032)1.75257077
97Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.74785259
98Absent epiphyses (HP:0010577)1.74785259
99Wrist flexion contracture (HP:0001239)1.73097787
100Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.72742822
101Aplasia/Hypoplasia of the uvula (HP:0010293)1.72456507
102Abnormality of the umbilical cord (HP:0010881)1.72322623
103Increased serum pyruvate (HP:0003542)1.72280271
104Abnormality of glycolysis (HP:0004366)1.72280271
105Facial cleft (HP:0002006)1.72064908
106Biliary tract neoplasm (HP:0100574)1.71281000
107Abnormality of serine family amino acid metabolism (HP:0010894)1.70286045
108Abnormality of glycine metabolism (HP:0010895)1.70286045
109Gonadotropin excess (HP:0000837)1.69895535
110Aplasia/Hypoplasia of the sternum (HP:0006714)1.69469134
111Hypoglycemic seizures (HP:0002173)1.69035296
112Pelvic girdle muscle weakness (HP:0003749)1.68426410
113Neoplasm of striated muscle (HP:0009728)1.66883221
114Small hand (HP:0200055)1.66441132
115Abnormality of the proximal phalanges of the hand (HP:0009834)1.65623049
116Focal motor seizures (HP:0011153)1.65409434
117Hypoplastic female external genitalia (HP:0012815)1.63937617
118Ureteral duplication (HP:0000073)1.62033331
119Abnormal umbilical cord blood vessels (HP:0011403)1.61925963
120Single umbilical artery (HP:0001195)1.61925963
121Abnormality of the fetal cardiovascular system (HP:0010948)1.61925963
122Ovarian neoplasm (HP:0100615)1.61773511
123Neoplasm of the adrenal cortex (HP:0100641)1.61770653
124Abnormality of the preputium (HP:0100587)1.61432696
125Microglossia (HP:0000171)1.61315560
126Breast carcinoma (HP:0003002)1.61291203
127Hepatoblastoma (HP:0002884)1.60958494
128Anophthalmia (HP:0000528)1.60778917
129Short hallux (HP:0010109)1.60239485
130Pendular nystagmus (HP:0012043)1.59972705
131Myokymia (HP:0002411)1.59465444
132Aqueductal stenosis (HP:0002410)1.59131762
133Chromsome breakage (HP:0040012)1.58405014
134Pterygium (HP:0001059)1.58395866
135Tongue fasciculations (HP:0001308)1.57945510
136Sensory axonal neuropathy (HP:0003390)1.57533769
137Aplasia/Hypoplasia of the hallux (HP:0008362)1.57325174
138Renal hypoplasia (HP:0000089)1.56714008
139Gastrointestinal carcinoma (HP:0002672)1.56702985
140Malignant gastrointestinal tract tumors (HP:0006749)1.56702985
141Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.56589100
142Neoplasm of the small intestine (HP:0100833)1.55926390
143Secondary amenorrhea (HP:0000869)1.55199954
144Oral leukoplakia (HP:0002745)1.54103877
145Multiple enchondromatosis (HP:0005701)1.53141450
146Personality changes (HP:0000751)1.53056953
147Adrenal hypoplasia (HP:0000835)1.52648341
148Small intestinal stenosis (HP:0012848)1.52388152
149Duodenal stenosis (HP:0100867)1.52388152
150Congenital stationary night blindness (HP:0007642)1.52244852
151Facial hemangioma (HP:0000329)1.51306357
152Fibular aplasia (HP:0002990)1.50863301
153Oligodactyly (HP:0012165)1.50402814
154Adenoma sebaceum (HP:0009720)1.50396908
155Angiofibromas (HP:0010615)1.50396908
156Septo-optic dysplasia (HP:0100842)1.50250998
157Abnormality of the salivary glands (HP:0010286)1.49722591
158Cortical dysplasia (HP:0002539)1.49608598
159Premature graying of hair (HP:0002216)1.49316811
160Focal seizures (HP:0007359)1.48439506
161Neoplasm of the pancreas (HP:0002894)1.47141477

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.50286363
2WEE13.81745948
3PNCK3.65019345
4TSSK63.52178843
5NEK13.15359704
6TNIK3.04256214
7AKT32.90189084
8LATS22.50425680
9TAF12.48662701
10EPHA22.42848648
11TRIM282.38909600
12NUAK12.33899289
13TTK2.30733414
14PBK2.23128306
15CDC72.15916530
16MARK12.10857115
17PLK32.09760066
18EIF2AK12.08737050
19TESK21.88023012
20SRPK11.87948363
21VRK21.74986424
22PLK11.74946910
23MAP3K91.69113558
24PLK41.60990714
25BMPR1B1.56863679
26ACVR1B1.50761032
27ALK1.48210580
28NEK21.46960414
29MST41.43959582
30CHEK21.32839356
31AURKA1.29782849
32CDK121.29502973
33MKNK11.28178512
34STK31.23590740
35BRSK11.23308735
36TIE11.21200762
37TGFBR11.17535429
38PDK21.15335913
39DYRK21.12962880
40PDK31.10891736
41PDK41.10891736
42LIMK11.10716522
43PAK61.10039716
44NTRK31.09772000
45ERBB31.09066243
46TLK11.09026899
47DDR21.08399763
48CDK71.07310101
49EIF2AK21.06824132
50TYRO31.06110382
51LATS11.05526266
52RPS6KB21.05112563
53CHEK11.04696449
54MKNK21.01359277
55BRSK21.00973384
56MINK11.00580698
57EIF2AK30.96833663
58PLK20.92283613
59CSNK1E0.89077683
60CSNK1G10.88548960
61STK38L0.88448584
62AURKB0.86113611
63ATR0.85917388
64MAP3K40.85514097
65PAK10.84539380
66STK160.84312091
67CDK20.84031389
68PRKCI0.83025929
69FLT30.81788649
70CDK150.80595662
71CDK140.79649713
72CDK180.79175795
73MAP3K100.79170158
74ZAK0.79044650
75DYRK30.77826359
76BRAF0.77610174
77MAP3K80.77329670
78NLK0.77008289
79KSR10.76639129
80CDK11A0.73048038
81NME10.72670125
82PASK0.70814069
83CDK10.69522318
84MAP4K20.68905635
85STK380.66320924
86VRK10.65368092
87BCR0.64869487
88NTRK20.64578664
89CLK10.62426932
90PRKCG0.60279420
91UHMK10.60252884
92WNK30.59321848
93CCNB10.59290874
94CSNK1G30.58980661
95CSNK2A20.58863875
96DMPK0.58548473
97PAK40.57634267
98STK240.57402509
99ICK0.55771619
100SCYL20.55534107
101ATM0.55426257
102MELK0.54813013
103OXSR10.51891020
104PAK20.50849704
105RPS6KA40.50498194
106GRK50.48895263
107CSNK1D0.46312769
108MTOR0.44385145
109MAPK100.43309181
110CSNK2A10.42709979
111CSNK1G20.42436675
112CDK60.42238827
113ERBB40.41777868
114STK40.41477400
115ARAF0.40257545
116CSNK1A1L0.39918006
117CDK190.39818479
118PAK30.39777895
119FGFR10.39759706
120BRD40.39736853
121AKT20.38596959
122TESK10.37567383
123NEK60.36876578
124GSK3B0.36704412
125YES10.36704259
126MAPKAPK30.36210436
127PRKDC0.35831603
128FGFR20.35669881
129GRK10.35333949
130CASK0.34113304
131STK390.33892971
132KSR20.33496525
133MET0.33137305
134CAMK1G0.31839158
135INSRR0.31327828
136DYRK1A0.30918071
137STK100.29468487
138ROCK20.29091346
139MAPK140.28789997
140PRKCE0.27945356
141NEK90.26834855

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.12492756
2RNA polymerase_Homo sapiens_hsa030203.51446258
3RNA transport_Homo sapiens_hsa030133.40210670
4Mismatch repair_Homo sapiens_hsa034303.31282951
5Proteasome_Homo sapiens_hsa030503.24729500
6DNA replication_Homo sapiens_hsa030303.05266571
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.98128774
8Spliceosome_Homo sapiens_hsa030402.91858613
9Vitamin B6 metabolism_Homo sapiens_hsa007502.85906695
10Protein export_Homo sapiens_hsa030602.65183530
11One carbon pool by folate_Homo sapiens_hsa006702.38168854
12Nucleotide excision repair_Homo sapiens_hsa034202.34517730
13Cell cycle_Homo sapiens_hsa041102.27189207
14Steroid biosynthesis_Homo sapiens_hsa001002.26818371
15Propanoate metabolism_Homo sapiens_hsa006402.08118190
16Ribosome_Homo sapiens_hsa030101.95081431
17mRNA surveillance pathway_Homo sapiens_hsa030151.83870517
18Pyrimidine metabolism_Homo sapiens_hsa002401.82088196
19Base excision repair_Homo sapiens_hsa034101.81466434
20Oocyte meiosis_Homo sapiens_hsa041141.80621821
21Homologous recombination_Homo sapiens_hsa034401.78026416
22Fanconi anemia pathway_Homo sapiens_hsa034601.73041514
23Phototransduction_Homo sapiens_hsa047441.69992776
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.69790052
25Basal transcription factors_Homo sapiens_hsa030221.64458837
26Synaptic vesicle cycle_Homo sapiens_hsa047211.60439969
27Selenocompound metabolism_Homo sapiens_hsa004501.56858052
28Pyruvate metabolism_Homo sapiens_hsa006201.55420756
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.41615972
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38263205
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.32846306
32RNA degradation_Homo sapiens_hsa030181.32440465
33Nicotine addiction_Homo sapiens_hsa050331.31864487
34p53 signaling pathway_Homo sapiens_hsa041151.24764461
35Purine metabolism_Homo sapiens_hsa002301.24101664
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.22366328
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.18856920
38Fatty acid elongation_Homo sapiens_hsa000621.14707356
39* Biosynthesis of amino acids_Homo sapiens_hsa012301.12721212
40Hippo signaling pathway_Homo sapiens_hsa043901.09992204
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.06232575
42Hedgehog signaling pathway_Homo sapiens_hsa043401.02012599
43Adherens junction_Homo sapiens_hsa045201.00442522
44Epstein-Barr virus infection_Homo sapiens_hsa051690.97032098
45Regulation of autophagy_Homo sapiens_hsa041400.92862449
46* Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91981927
47Non-homologous end-joining_Homo sapiens_hsa034500.91946142
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90604377
49Collecting duct acid secretion_Homo sapiens_hsa049660.85161595
50Huntingtons disease_Homo sapiens_hsa050160.81321279
51Fructose and mannose metabolism_Homo sapiens_hsa000510.78863303
52Glutathione metabolism_Homo sapiens_hsa004800.78432958
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77934774
54mTOR signaling pathway_Homo sapiens_hsa041500.76587729
55GABAergic synapse_Homo sapiens_hsa047270.75450681
56Tight junction_Homo sapiens_hsa045300.73315016
57* Cysteine and methionine metabolism_Homo sapiens_hsa002700.72727549
58Alcoholism_Homo sapiens_hsa050340.70308908
59Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68822015
60Basal cell carcinoma_Homo sapiens_hsa052170.65856432
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64308476
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63020035
63Viral carcinogenesis_Homo sapiens_hsa052030.61925875
64Gap junction_Homo sapiens_hsa045400.61602623
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58644042
66Oxidative phosphorylation_Homo sapiens_hsa001900.58055044
67Fatty acid metabolism_Homo sapiens_hsa012120.57042567
68Vibrio cholerae infection_Homo sapiens_hsa051100.56478167
69Lysine degradation_Homo sapiens_hsa003100.55571534
70Parkinsons disease_Homo sapiens_hsa050120.54403454
71Wnt signaling pathway_Homo sapiens_hsa043100.54356212
72* Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54107837
73Vitamin digestion and absorption_Homo sapiens_hsa049770.53992465
74Folate biosynthesis_Homo sapiens_hsa007900.53760565
75Long-term potentiation_Homo sapiens_hsa047200.53356368
76Colorectal cancer_Homo sapiens_hsa052100.53241942
77Dopaminergic synapse_Homo sapiens_hsa047280.51687924
78Carbon metabolism_Homo sapiens_hsa012000.51280570
79TGF-beta signaling pathway_Homo sapiens_hsa043500.50180933
80MicroRNAs in cancer_Homo sapiens_hsa052060.49935993
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49744857
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48919312
83Amphetamine addiction_Homo sapiens_hsa050310.48837937
84N-Glycan biosynthesis_Homo sapiens_hsa005100.48781917
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48033785
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45418085
87* Metabolic pathways_Homo sapiens_hsa011000.43181685
88Systemic lupus erythematosus_Homo sapiens_hsa053220.42730333
89Long-term depression_Homo sapiens_hsa047300.42278512
90Melanoma_Homo sapiens_hsa052180.42190987
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.41429727
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39511354
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.39376243
94Axon guidance_Homo sapiens_hsa043600.38810188
95Glutamatergic synapse_Homo sapiens_hsa047240.38743729
96ErbB signaling pathway_Homo sapiens_hsa040120.37765031
97Pentose phosphate pathway_Homo sapiens_hsa000300.36995058
98Renal cell carcinoma_Homo sapiens_hsa052110.36584113
99ECM-receptor interaction_Homo sapiens_hsa045120.35260742
100Cardiac muscle contraction_Homo sapiens_hsa042600.33697030
101HIF-1 signaling pathway_Homo sapiens_hsa040660.33576450
102Proteoglycans in cancer_Homo sapiens_hsa052050.32911855
103Arginine and proline metabolism_Homo sapiens_hsa003300.32593346
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.32516819
105Olfactory transduction_Homo sapiens_hsa047400.31893854
106* 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.31413790
107Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.31380565
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30962227
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30707754
110Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29544384
111Serotonergic synapse_Homo sapiens_hsa047260.29384883
112Estrogen signaling pathway_Homo sapiens_hsa049150.29092237
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.29068276
114Bladder cancer_Homo sapiens_hsa052190.27833239
115Taste transduction_Homo sapiens_hsa047420.27037545
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26884229
117Melanogenesis_Homo sapiens_hsa049160.24623965
118HTLV-I infection_Homo sapiens_hsa051660.23445681
119Fatty acid degradation_Homo sapiens_hsa000710.22662805
120Morphine addiction_Homo sapiens_hsa050320.20951491
121Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.20415074
122Protein digestion and absorption_Homo sapiens_hsa049740.20177738
123Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.20163796
124Inositol phosphate metabolism_Homo sapiens_hsa005620.19219951
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.19091905
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18626680
127Pathways in cancer_Homo sapiens_hsa052000.18437442
128Thyroid cancer_Homo sapiens_hsa052160.18327594
129beta-Alanine metabolism_Homo sapiens_hsa004100.18037024
130Peroxisome_Homo sapiens_hsa041460.17880775
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17769668
132Fat digestion and absorption_Homo sapiens_hsa049750.15920183
133Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.13412299
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.13206558
135Butanoate metabolism_Homo sapiens_hsa006500.13055106
136Galactose metabolism_Homo sapiens_hsa000520.13029097
137Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.11905251

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