BCKDHA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The branched-chain alpha-keto acid (BCAA) dehydrogenase (BCKD) complex is an innter mitochondrial enzyme complex that catalyzes the second major step in the catabolism of the branched-chain amino acids leucine, isoleucine, and valine. The BCKD complex consists of three catalytic components: a heterotetrameric (alpha2-beta2) branched-chain alpha-keto acid decarboxylase (E1), a dihydrolipoyl transacylase (E2), and a dihydrolipoamide dehydrogenase (E3). This gene encodes the alpha subunit of the decarboxylase (E1) component. Mutations in this gene result in maple syrup urine disease, type IA. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.53065925
2L-phenylalanine catabolic process (GO:0006559)6.53065925
3L-phenylalanine metabolic process (GO:0006558)6.41512528
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.41512528
5lysine catabolic process (GO:0006554)5.79397219
6lysine metabolic process (GO:0006553)5.79397219
7aromatic amino acid family catabolic process (GO:0009074)5.74975639
8glyoxylate metabolic process (GO:0046487)5.69607925
9pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.50332382
10alpha-linolenic acid metabolic process (GO:0036109)5.33152128
11kynurenine metabolic process (GO:0070189)5.29573191
12cysteine metabolic process (GO:0006534)5.25144049
13fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.22779645
14sulfur amino acid catabolic process (GO:0000098)5.18092125
15deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.13605915
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.12992287
17tryptophan catabolic process (GO:0006569)5.12912764
18indole-containing compound catabolic process (GO:0042436)5.12912764
19indolalkylamine catabolic process (GO:0046218)5.12912764
20iron-sulfur cluster assembly (GO:0016226)5.07334543
21metallo-sulfur cluster assembly (GO:0031163)5.07334543
22bile acid biosynthetic process (GO:0006699)4.86846678
23serine family amino acid catabolic process (GO:0009071)4.85748568
24tryptophan metabolic process (GO:0006568)4.83947151
25amino-acid betaine metabolic process (GO:0006577)4.82907849
26fatty acid beta-oxidation (GO:0006635)4.76733660
272-oxoglutarate metabolic process (GO:0006103)4.76216574
28valine metabolic process (GO:0006573)4.69228971
29pyrimidine nucleotide catabolic process (GO:0006244)4.63967608
30DNA deamination (GO:0045006)4.60695690
31regulation of triglyceride catabolic process (GO:0010896)4.60428704
32acetyl-CoA metabolic process (GO:0006084)4.55633824
33cellular ketone body metabolic process (GO:0046950)4.54798831
34short-chain fatty acid metabolic process (GO:0046459)4.54615067
35aspartate family amino acid catabolic process (GO:0009068)4.53690651
36urea metabolic process (GO:0019627)4.52315372
37urea cycle (GO:0000050)4.52315372
38homocysteine metabolic process (GO:0050667)4.52176629
39fatty acid oxidation (GO:0019395)4.45786840
40alpha-amino acid catabolic process (GO:1901606)4.43344976
41lipid oxidation (GO:0034440)4.37280822
42fatty acid catabolic process (GO:0009062)4.36120698
43ethanol oxidation (GO:0006069)4.34414934
44negative regulation of fibrinolysis (GO:0051918)4.27028585
45complement activation, alternative pathway (GO:0006957)4.26537392
46nitrogen cycle metabolic process (GO:0071941)4.25860465
47peptidyl-glutamic acid carboxylation (GO:0017187)4.20659817
48protein carboxylation (GO:0018214)4.20659817
49* cellular amino acid catabolic process (GO:0009063)4.19366063
50aromatic amino acid family metabolic process (GO:0009072)4.19200553
51high-density lipoprotein particle remodeling (GO:0034375)4.18529771
52chaperone-mediated protein transport (GO:0072321)4.17675534
53monocarboxylic acid catabolic process (GO:0072329)4.15517691
54fatty acid transmembrane transport (GO:1902001)4.14110704
55bile acid metabolic process (GO:0008206)4.10360593
56cellular modified amino acid catabolic process (GO:0042219)4.10224102
57carnitine metabolic process (GO:0009437)4.08856644
58serine family amino acid metabolic process (GO:0009069)4.07392408
59glycine metabolic process (GO:0006544)4.06195331
60regulation of protein activation cascade (GO:2000257)4.05219619
61biotin metabolic process (GO:0006768)4.01045853
62* branched-chain amino acid catabolic process (GO:0009083)4.00843948
63deoxyribonucleotide catabolic process (GO:0009264)3.97963040
64regulation of fibrinolysis (GO:0051917)3.97952780
65* organic acid catabolic process (GO:0016054)3.97269220
66* carboxylic acid catabolic process (GO:0046395)3.97269220
67triglyceride homeostasis (GO:0070328)3.97030732
68acylglycerol homeostasis (GO:0055090)3.97030732
69carnitine shuttle (GO:0006853)3.95408341
70coenzyme catabolic process (GO:0009109)3.91305390
71ketone body metabolic process (GO:1902224)3.91155853
72* branched-chain amino acid metabolic process (GO:0009081)3.90131906
73positive regulation of fatty acid beta-oxidation (GO:0032000)3.87836252
74plasma lipoprotein particle clearance (GO:0034381)3.87072352
75tyrosine metabolic process (GO:0006570)3.84356316
76glutamate metabolic process (GO:0006536)3.83165669
77tricarboxylic acid metabolic process (GO:0072350)3.83092776
78protein complex biogenesis (GO:0070271)3.81577082
79regulation of complement activation (GO:0030449)3.81238677
80pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.78276055
81oxidative phosphorylation (GO:0006119)3.77495812
82serine family amino acid biosynthetic process (GO:0009070)3.76044945
83dicarboxylic acid biosynthetic process (GO:0043650)3.72820710
84mitochondrial respiratory chain complex I assembly (GO:0032981)3.71144130
85NADH dehydrogenase complex assembly (GO:0010257)3.71144130
86mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.71144130
87mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.70991756
88ubiquinone biosynthetic process (GO:0006744)3.70316305
89drug transmembrane transport (GO:0006855)3.70034691
90negative regulation of cholesterol transport (GO:0032375)3.69909384
91negative regulation of sterol transport (GO:0032372)3.69909384
92reverse cholesterol transport (GO:0043691)3.69829005
93deoxyribose phosphate catabolic process (GO:0046386)3.68379924
94plasma lipoprotein particle remodeling (GO:0034369)3.68074225
95protein-lipid complex remodeling (GO:0034368)3.68074225
96macromolecular complex remodeling (GO:0034367)3.68074225
97benzene-containing compound metabolic process (GO:0042537)3.66581864
98NADH metabolic process (GO:0006734)3.65922860
99regulation of cholesterol esterification (GO:0010872)3.64673534
100regulation of sequestering of triglyceride (GO:0010889)3.63817073
101positive regulation of lipid catabolic process (GO:0050996)3.60388573
102cytidine metabolic process (GO:0046087)3.59071691
103cytidine catabolic process (GO:0006216)3.59071691
104cytidine deamination (GO:0009972)3.59071691
105urate metabolic process (GO:0046415)3.56900974
106drug catabolic process (GO:0042737)3.56298298
107base-excision repair, AP site formation (GO:0006285)3.55805796
108indolalkylamine metabolic process (GO:0006586)3.55214730
109respiratory electron transport chain (GO:0022904)3.54069828
110phospholipid homeostasis (GO:0055091)3.53445435
111negative regulation of B cell apoptotic process (GO:0002903)3.51235916
112positive regulation of fatty acid oxidation (GO:0046321)3.51066815
113oxaloacetate metabolic process (GO:0006107)3.49035970
114mitochondrial respiratory chain complex assembly (GO:0033108)3.48095496
115electron transport chain (GO:0022900)3.47213708
116regulation of cholesterol homeostasis (GO:2000188)3.46460809
117regulation of mitochondrial translation (GO:0070129)3.46172308
118regulation of fatty acid beta-oxidation (GO:0031998)3.45701519
119energy coupled proton transport, down electrochemical gradient (GO:0015985)3.42732513
120ATP synthesis coupled proton transport (GO:0015986)3.42732513
121deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.42091436
122phospholipid efflux (GO:0033700)3.41949169
123amine catabolic process (GO:0009310)3.40419101
124cellular biogenic amine catabolic process (GO:0042402)3.40419101
125regulation of fatty acid oxidation (GO:0046320)3.40333580
126tricarboxylic acid cycle (GO:0006099)3.39558691
127negative regulation of fatty acid biosynthetic process (GO:0045717)3.38930673
128regulation of cholesterol metabolic process (GO:0090181)3.37637966
129cellular glucuronidation (GO:0052695)3.37489238
130amino-acid betaine transport (GO:0015838)3.36197489
131purine nucleotide salvage (GO:0032261)3.35309838
132GDP-mannose metabolic process (GO:0019673)3.35096647
133mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.29568092
134ubiquinone metabolic process (GO:0006743)3.26628836
135amino acid salvage (GO:0043102)3.22097809
136L-methionine salvage (GO:0071267)3.22097809
137L-methionine biosynthetic process (GO:0071265)3.22097809
138peptidyl-arginine omega-N-methylation (GO:0035247)3.17718074
1392-deoxyribonucleotide metabolic process (GO:0009394)3.16094257
140ribosomal small subunit assembly (GO:0000028)3.15441087
141respiratory chain complex IV assembly (GO:0008535)3.14107654
142cytochrome complex assembly (GO:0017004)3.12577275
143positive regulation of mitochondrial fission (GO:0090141)3.10381549
144quinone biosynthetic process (GO:1901663)3.09957189
145L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.08960653
146establishment of protein localization to mitochondrial membrane (GO:0090151)3.07524513
147pseudouridine synthesis (GO:0001522)3.06421010
148response to misfolded protein (GO:0051788)3.05994297
149purine deoxyribonucleotide catabolic process (GO:0009155)3.03451559
150pyrimidine ribonucleoside catabolic process (GO:0046133)3.00469464
151protein targeting to mitochondrion (GO:0006626)2.98855280
152regulation of cellular amino acid metabolic process (GO:0006521)2.96598400
153protein deneddylation (GO:0000338)2.96119947
154deoxyribose phosphate metabolic process (GO:0019692)2.91362223
155creatine metabolic process (GO:0006600)2.91005056
156negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.87684313
157galactose catabolic process (GO:0019388)2.81938458
158establishment of protein localization to mitochondrion (GO:0072655)2.81710279
159mannosylation (GO:0097502)2.79948064
160purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.78058150
161aerobic respiration (GO:0009060)2.77692595
162chaperone mediated protein folding requiring cofactor (GO:0051085)2.75834333
163actin-myosin filament sliding (GO:0033275)2.74101672
164muscle filament sliding (GO:0030049)2.74101672
165protein-cofactor linkage (GO:0018065)2.73413420
166gluconeogenesis (GO:0006094)2.71026087
167proteasome assembly (GO:0043248)2.69707271
168positive regulation of prostaglandin secretion (GO:0032308)2.69237772
169DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.67015944
170heme biosynthetic process (GO:0006783)2.66896184
171negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.66617761
172nucleotide salvage (GO:0043173)2.66415600
173purine deoxyribonucleotide metabolic process (GO:0009151)2.65571546
174GPI anchor biosynthetic process (GO:0006506)2.63634884
175heme metabolic process (GO:0042168)2.63439717
176protein localization to mitochondrion (GO:0070585)2.61103343
177deoxyribonucleotide metabolic process (GO:0009262)2.60580385
178inner mitochondrial membrane organization (GO:0007007)2.59705284
179L-serine metabolic process (GO:0006563)2.59336694
180S-adenosylmethionine metabolic process (GO:0046500)2.56525090
181tRNA modification (GO:0006400)2.56289307
182Arp2/3 complex-mediated actin nucleation (GO:0034314)2.55950120
183cullin deneddylation (GO:0010388)2.55508312
184signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.55293097
185intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.55293097
186signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.54570201
187signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.54570201
188signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.54570201
189tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.54113945
190RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.54113945
191purine-containing compound salvage (GO:0043101)2.53903514
192preassembly of GPI anchor in ER membrane (GO:0016254)2.52435573

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.46284015
2RXR_22158963_ChIP-Seq_LIVER_Mouse7.22161598
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.40580281
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.55196766
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.00638158
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.54731166
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.09968677
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.71875531
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.69867743
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.57374768
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.51244682
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.32860029
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.11527445
14ELF1_17652178_ChIP-ChIP_JURKAT_Human3.09853684
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.90437865
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.87438248
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.84417782
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.83724696
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.70268363
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.52341637
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.51913878
22* SRF_21415370_ChIP-Seq_HL-1_Mouse2.48765792
23* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.47093636
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.46307588
25CREB1_15753290_ChIP-ChIP_HEK293T_Human2.36209400
26CLOCK_20551151_ChIP-Seq_293T_Human2.30263661
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.26092470
28YY1_21170310_ChIP-Seq_MESCs_Mouse2.24928673
29MYC_18555785_ChIP-Seq_MESCs_Mouse2.21851475
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.19307268
31GABP_19822575_ChIP-Seq_HepG2_Human2.14308986
32VDR_23849224_ChIP-Seq_CD4+_Human2.09701546
33HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.02408379
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.01484606
35FOXP3_21729870_ChIP-Seq_TREG_Human2.00908608
36ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.2955536
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.99044213
38TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.90626819
39XRN2_22483619_ChIP-Seq_HELA_Human1.90248922
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.87358195
41* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.87067212
42ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.86332120
43ZNF263_19887448_ChIP-Seq_K562_Human1.81483581
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.80737044
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.79772116
46DCP1A_22483619_ChIP-Seq_HELA_Human1.78168661
47* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.77173269
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.76919590
49* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.76685872
50* CIITA_25753668_ChIP-Seq_RAJI_Human1.74804365
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.70338380
52VDR_21846776_ChIP-Seq_THP-1_Human1.67519641
53E2F1_18555785_ChIP-Seq_MESCs_Mouse1.66569907
54* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.65991750
55ELF1_20517297_ChIP-Seq_JURKAT_Human1.61758469
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54556581
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.53231198
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48563450
59CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.45913941
60MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.41776182
61FOXA2_19822575_ChIP-Seq_HepG2_Human1.40592226
62GATA1_22025678_ChIP-Seq_K562_Human1.40312758
63TTF2_22483619_ChIP-Seq_HELA_Human1.38418945
64STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.38172503
65SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33499446
66KDM5A_27292631_Chip-Seq_BREAST_Human1.33180583
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.33026191
68ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.31362827
69MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29787805
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29643938
71NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.29006695
72STAT3_1855785_ChIP-Seq_MESCs_Mouse1.26602355
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26123325
74CTCF_26484167_Chip-Seq_Bcells_Mouse1.25685261
75MYC_22102868_ChIP-Seq_BL_Human1.25064556
76HNF4A_19822575_ChIP-Seq_HepG2_Human1.24269813
77EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.23467090
78* FOXP1_21924763_ChIP-Seq_HESCs_Human1.21971669
79YY1_22570637_ChIP-Seq_MALME-3M_Human1.20912284
80DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20526470
81NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20175172
82STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19743881
83CTCF_18555785_ChIP-Seq_MESCs_Mouse1.19493067
84MAF_26560356_Chip-Seq_TH2_Human1.18212269
85LXR_22292898_ChIP-Seq_THP-1_Human1.17438758
86IRF1_19129219_ChIP-ChIP_H3396_Human1.16783993
87LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16625345
88SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.16006227
89ESR2_21235772_ChIP-Seq_MCF-7_Human1.15955898
90RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.15363848
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13580810
92SOX2_27498859_Chip-Seq_STOMACH_Mouse1.12930075
93UTX_26944678_Chip-Seq_JUKART_Human1.12706646
94* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12601509
95MYC_19079543_ChIP-ChIP_MESCs_Mouse1.12029434
96PHF8_20622854_ChIP-Seq_HELA_Human1.11030858
97TBX20_22080862_ChIP-Seq_HEART_Mouse1.09893758
98TBX20_22328084_ChIP-Seq_HEART_Mouse1.09893758
99PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.07909513
100E2F1_20622854_ChIP-Seq_HELA_Human1.07835576
101PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05309602
102RXRA_24833708_ChIP-Seq_LIVER_Mouse1.04973995
103SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.03851964
104PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.03573659
105ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03375961
106MAF_26560356_Chip-Seq_TH1_Human0.99729765
107SA1_27219007_Chip-Seq_ERYTHROID_Human0.97787114
108IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.96428330
109FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96395412
110PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95944941
111SA1_27219007_Chip-Seq_Bcells_Human0.94312136
112* POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94143073
113PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94130551
114LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.93657316
115SPI1_23547873_ChIP-Seq_NB4_Human0.93084273
116CTCF_20526341_ChIP-Seq_ESCs_Human0.92469445
117PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.89552629
118ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88166726
119GATA4_25053715_ChIP-Seq_YYC3_Human0.87245374
120RACK7_27058665_Chip-Seq_MCF-7_Human0.87240772
121ESR1_21235772_ChIP-Seq_MCF-7_Human0.86807876
122CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.86775123
123SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.81075300
124TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78802570
125BCOR_27268052_Chip-Seq_Bcells_Human0.76656223
126ESR1_20079471_ChIP-ChIP_T-47D_Human0.75106896
127HTT_18923047_ChIP-ChIP_STHdh_Human0.74941911
128TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.74252821
129P68_20966046_ChIP-Seq_HELA_Human0.73631052
130RARA_24833708_ChIP-Seq_LIVER_Mouse0.73589156
131SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.73538400
132EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.72906648
133SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.72104208
134RAD21_21589869_ChIP-Seq_MESCs_Mouse0.70536736
135BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.70519700
136POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.70027642
137TET1_21451524_ChIP-Seq_MESCs_Mouse0.69926638
138IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.69802205
139ESR1_15608294_ChIP-ChIP_MCF-7_Human0.69401679
140BCL6_27268052_Chip-Seq_Bcells_Human0.68950553
141AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.67985703
142PPAR_26484153_Chip-Seq_NCI-H1993_Human0.67959008
143AUTS2_25519132_ChIP-Seq_293T-REX_Human0.67871462
144CEBPB_22108803_ChIP-Seq_LS180_Human0.67281632
145ATF3_27146783_Chip-Seq_COLON_Human0.67123881
146RARB_24833708_ChIP-Seq_LIVER_Mouse0.66816221
147GATA1_19941826_ChIP-Seq_K562_Human0.65229682
148GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.64605936
149GATA1_19941827_ChIP-Seq_MEL_Mouse0.63889581
150FOXO3_23340844_ChIP-Seq_DLD1_Human0.63482089
151GATA6_25053715_ChIP-Seq_YYC3_Human0.62851928
152KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.62525891
153CTCF_21964334_Chip-Seq_Bcells_Human0.62488715
154ELK3_25401928_ChIP-Seq_HUVEC_Human0.62402849
155CTCF_21964334_ChIP-Seq_BJAB-B_Human0.61859489
156BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.61472247
157SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.60420514
158GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.58852026
159CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.58243327
160PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.57154726
161IRF8_22096565_ChIP-ChIP_GC-B_Human0.56970040
162BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.56915292
163SALL4_18804426_ChIP-ChIP_XEN_Mouse0.55310970
164CREB1_26743006_Chip-Seq_LNCaP_Human0.54942289
165EGR1_19032775_ChIP-ChIP_M12_Human0.54794604
166GATA2_19941826_ChIP-Seq_K562_Human0.54214912
167TAF2_19829295_ChIP-Seq_ESCs_Human0.53881020
168CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.53539211
169SPI1_20517297_ChIP-Seq_HL60_Human0.52785669
170P63_26484246_Chip-Seq_KERATINOCYTES_Human0.52742516
171P300_27268052_Chip-Seq_Bcells_Human0.52681842
172PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52407951
173RAC3_21632823_ChIP-Seq_H3396_Human0.52108151
174TP63_22573176_ChIP-Seq_HFKS_Human0.51483366
175SOX2_18692474_ChIP-Seq_MEFs_Mouse0.51361100
176GATA1_22383799_ChIP-Seq_G1ME_Mouse0.51091825
177RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.51090137
178RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.50812866
179FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.50675202

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.89372473
2MP0005360_urolithiasis6.42640051
3MP0005365_abnormal_bile_salt5.31205779
4MP0005085_abnormal_gallbladder_physiolo5.20536276
5MP0008875_abnormal_xenobiotic_pharmacok4.13011986
6MP0003806_abnormal_nucleotide_metabolis4.01960036
7MP0004145_abnormal_muscle_electrophysio3.66879894
8MP0010329_abnormal_lipoprotein_level3.19493282
9MP0003252_abnormal_bile_duct3.13804974
10MP0005332_abnormal_amino_acid3.03818714
11MP0009840_abnormal_foam_cell2.91414132
12MP0002837_dystrophic_cardiac_calcinosis2.73845339
13MP0000372_irregular_coat_pigmentation2.72520520
14MP0005083_abnormal_biliary_tract2.69609030
15MP0008995_early_reproductive_senescence2.68083419
16MP0003195_calcinosis2.55068909
17MP0003191_abnormal_cellular_cholesterol2.42550560
18MP0001666_abnormal_nutrient_absorption2.38820631
19MP0005671_abnormal_response_to2.35947700
20MP0005670_abnormal_white_adipose2.35570541
21MP0002118_abnormal_lipid_homeostasis2.15284911
22MP0003786_premature_aging2.11672897
23MP0005645_abnormal_hypothalamus_physiol2.05150507
24MP0004130_abnormal_muscle_cell2.03923764
25MP0000609_abnormal_liver_physiology2.01198086
26MP0004019_abnormal_vitamin_homeostasis2.00469897
27MP0005319_abnormal_enzyme/_coenzyme1.97164047
28MP0003646_muscle_fatigue1.94803630
29MP0002653_abnormal_ependyma_morphology1.86385977
30MP0008058_abnormal_DNA_repair1.77576918
31MP0001529_abnormal_vocalization1.76608231
32MP0006036_abnormal_mitochondrial_physio1.74764568
33MP0005666_abnormal_adipose_tissue1.73140232
34MP0009643_abnormal_urine_homeostasis1.70552813
35MP0005584_abnormal_enzyme/coenzyme_acti1.68714568
36MP0002138_abnormal_hepatobiliary_system1.60996066
37MP0005075_abnormal_melanosome_morpholog1.58027465
38MP0009333_abnormal_splenocyte_physiolog1.57340335
39MP0003705_abnormal_hypodermis_morpholog1.56648092
40MP0003186_abnormal_redox_activity1.54186114
41MP0001764_abnormal_homeostasis1.51904047
42MP0005451_abnormal_body_composition1.42350430
43MP0001984_abnormal_olfaction1.39588667
44MP0002148_abnormal_hypersensitivity_rea1.38935191
45MP0001835_abnormal_antigen_presentation1.38352305
46MP0005330_cardiomyopathy1.37701198
47MP0001800_abnormal_humoral_immune1.30559467
48MP0003868_abnormal_feces_composition1.29388882
49MP0000685_abnormal_immune_system1.29232077
50MP0005000_abnormal_immune_tolerance1.28065346
51MP0003436_decreased_susceptibility_to1.26388025
52MP0005025_abnormal_response_to1.25694769
53MP0009785_altered_susceptibility_to1.25237883
54MP0002971_abnormal_brown_adipose1.24956728
55MP0002723_abnormal_immune_serum1.24234570
56MP0001727_abnormal_embryo_implantation1.23951211
57MP0004084_abnormal_cardiac_muscle1.19305194
58MP0001790_abnormal_immune_system1.18078795
59MP0005387_immune_system_phenotype1.18078795
60MP0003763_abnormal_thymus_physiology1.18034401
61MP0002420_abnormal_adaptive_immunity1.17204289
62MP0002822_catalepsy1.14359634
63MP0000751_myopathy1.13137295
64MP0004043_abnormal_pH_regulation1.13099660
65MP0002132_abnormal_respiratory_system1.13010426
66MP0001819_abnormal_immune_cell1.12976857
67MP0006276_abnormal_autonomic_nervous1.12966359
68MP0004036_abnormal_muscle_relaxation1.10696330
69MP0000598_abnormal_liver_morphology1.10561030
70MP0005636_abnormal_mineral_homeostasis1.10079313
71MP0003878_abnormal_ear_physiology1.09299705
72MP0005377_hearing/vestibular/ear_phenot1.09299705
73MP0004185_abnormal_adipocyte_glucose1.06780909
74MP0002722_abnormal_immune_system1.06281508
75MP0000689_abnormal_spleen_morphology1.05064270
76MP0001756_abnormal_urination1.04389183
77MP0003656_abnormal_erythrocyte_physiolo1.03921478
78MP0002269_muscular_atrophy1.03580810
79MP0002078_abnormal_glucose_homeostasis1.03443280
80MP0005375_adipose_tissue_phenotype1.02669760
81MP0002398_abnormal_bone_marrow1.00440160
82MP0005535_abnormal_body_temperature0.98938723
83MP0000716_abnormal_immune_system0.97689363
84MP0000358_abnormal_cell_content/0.96827878
85MP0005334_abnormal_fat_pad0.96800523
86MP0000749_muscle_degeneration0.94214317
87MP0002429_abnormal_blood_cell0.92782312
88MP0006035_abnormal_mitochondrial_morpho0.92751438
89MP0004087_abnormal_muscle_fiber0.92586959
90MP0002452_abnormal_antigen_presenting0.92288377
91MP0005266_abnormal_metabolism0.92222265
92MP0001905_abnormal_dopamine_level0.92095336
93MP0004215_abnormal_myocardial_fiber0.91977185
94MP0005464_abnormal_platelet_physiology0.90730493
95MP0008260_abnormal_autophagy0.90127473
96MP0008872_abnormal_physiological_respon0.89965747
97MP0005647_abnormal_sex_gland0.88884436
98MP0005369_muscle_phenotype0.88593742
99MP0010368_abnormal_lymphatic_system0.88449996
100MP0004233_abnormal_muscle_weight0.88448144
101MP0009642_abnormal_blood_homeostasis0.86687912
102MP0009763_increased_sensitivity_to0.86098582
103MP0003011_delayed_dark_adaptation0.86072448
104MP0008789_abnormal_olfactory_epithelium0.83662649
105MP0001544_abnormal_cardiovascular_syste0.81150572
106MP0005385_cardiovascular_system_phenoty0.81150572
107MP0010094_abnormal_chromosome_stability0.81013375
108MP0004142_abnormal_muscle_tone0.80789250
109MP0003221_abnormal_cardiomyocyte_apopto0.80023963
110MP0005376_homeostasis/metabolism_phenot0.79762824
111MP0008469_abnormal_protein_level0.78902993
112MP0000747_muscle_weakness0.78825749
113MP0009764_decreased_sensitivity_to0.77869496
114MP0001661_extended_life_span0.77557617
115MP0000703_abnormal_thymus_morphology0.76924789
116MP0000604_amyloidosis0.76828393
117MP0001873_stomach_inflammation0.75746704
118MP0005058_abnormal_lysosome_morphology0.75640501
119MP0006138_congestive_heart_failure0.75386543
120MP0002136_abnormal_kidney_physiology0.75061943
121MP0008775_abnormal_heart_ventricle0.74553934
122MP0010630_abnormal_cardiac_muscle0.73879604
123MP0005394_taste/olfaction_phenotype0.73531943
124MP0005499_abnormal_olfactory_system0.73531943
125MP0005220_abnormal_exocrine_pancreas0.72444323
126MP0009697_abnormal_copulation0.71824520
127MP0002972_abnormal_cardiac_muscle0.71081171
128MP0006072_abnormal_retinal_apoptosis0.71000517
129MP0005620_abnormal_muscle_contractility0.69480615
130MP0009115_abnormal_fat_cell0.69356950
131MP0000750_abnormal_muscle_regeneration0.68027071
132MP0000230_abnormal_systemic_arterial0.67575922
133MP0002970_abnormal_white_adipose0.67438626
134MP0002254_reproductive_system_inflammat0.66925895
135MP0005448_abnormal_energy_balance0.65467717
136MP0001765_abnormal_ion_homeostasis0.64616202
137MP0002876_abnormal_thyroid_physiology0.63034386
138MP0005084_abnormal_gallbladder_morpholo0.59927564
139MP0002332_abnormal_exercise_endurance0.57610322
140MP0003329_amyloid_beta_deposits0.55895504
141MP0003959_abnormal_lean_body0.53300452
142MP0003953_abnormal_hormone_level0.52418277
143MP0008961_abnormal_basal_metabolism0.52353811
144MP0003690_abnormal_glial_cell0.52094613
145MP0009765_abnormal_xenobiotic_induced0.51370862
146MP0003137_abnormal_impulse_conducting0.49609324
147MP0002106_abnormal_muscle_physiology0.46203892
148MP0001853_heart_inflammation0.45681197
149MP0003638_abnormal_response/metabolism_0.45552640
150MP0005165_increased_susceptibility_to0.45501175
151MP0000343_altered_response_to0.45494519
152MP0000759_abnormal_skeletal_muscle0.44651145
153MP0004147_increased_porphyrin_level0.43851090

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.72503822
2Intrahepatic cholestasis (HP:0001406)5.32173574
3Deep venous thrombosis (HP:0002625)5.30464038
4Hyperglycinuria (HP:0003108)5.20175447
5Xanthomatosis (HP:0000991)5.09020746
6Hyperammonemia (HP:0001987)4.88656888
7Abnormality of monocarboxylic acid metabolism (HP:0010996)4.85770798
8Increased intramyocellular lipid droplets (HP:0012240)4.78694100
9Abnormality of glycine metabolism (HP:0010895)4.77611307
10Abnormality of serine family amino acid metabolism (HP:0010894)4.77611307
11* Ketosis (HP:0001946)4.67254014
12Abnormal mitochondria in muscle tissue (HP:0008316)4.61577000
13Abnormality of fatty-acid metabolism (HP:0004359)4.55184266
14Hypoglycemic coma (HP:0001325)4.54746875
15Hyperglycinemia (HP:0002154)4.51008112
16Acute necrotizing encephalopathy (HP:0006965)4.42526845
17Hyperlipoproteinemia (HP:0010980)4.39969329
18Mitochondrial inheritance (HP:0001427)4.34982006
19Hypobetalipoproteinemia (HP:0003563)4.32253855
20Ketoacidosis (HP:0001993)4.25826017
21Hepatocellular necrosis (HP:0001404)4.24344537
22Prolonged partial thromboplastin time (HP:0003645)4.19877463
23Complement deficiency (HP:0004431)3.94311659
24Abnormality of glutamine family amino acid metabolism (HP:0010902)3.90191667
25Abnormality of glycolysis (HP:0004366)3.89334526
26Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.88447287
27Increased CSF lactate (HP:0002490)3.83368849
28Dicarboxylic aciduria (HP:0003215)3.76849863
29Abnormality of dicarboxylic acid metabolism (HP:0010995)3.76849863
30Increased serum pyruvate (HP:0003542)3.76512105
31Hypolipoproteinemia (HP:0010981)3.71418539
32Lipid accumulation in hepatocytes (HP:0006561)3.68654390
33Hypoalphalipoproteinemia (HP:0003233)3.67836702
34Gout (HP:0001997)3.51666282
35Increased hepatocellular lipid droplets (HP:0006565)3.51581173
36Exercise intolerance (HP:0003546)3.51575817
37Abnormality of aspartate family amino acid metabolism (HP:0010899)3.50506451
38Abnormality of sulfur amino acid metabolism (HP:0004339)3.49817886
39Myoglobinuria (HP:0002913)3.46108181
40Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.45911022
41Decreased activity of mitochondrial respiratory chain (HP:0008972)3.45322767
42Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.45322767
43Progressive macrocephaly (HP:0004481)3.44419353
44Epidermoid cyst (HP:0200040)3.38290448
45Renal Fanconi syndrome (HP:0001994)3.28612082
46Generalized aminoaciduria (HP:0002909)3.27229563
47* Lactic acidosis (HP:0003128)3.26583339
48Nemaline bodies (HP:0003798)3.17155964
49Muscle fiber inclusion bodies (HP:0100299)3.13855429
50Abnormality of the common coagulation pathway (HP:0010990)3.13654159
51Abnormality of serum amino acid levels (HP:0003112)3.13485858
52Abnormality of purine metabolism (HP:0004352)3.12635230
53Metabolic acidosis (HP:0001942)3.12004563
54Joint hemorrhage (HP:0005261)3.11771164
55Abnormality of methionine metabolism (HP:0010901)3.11596734
56Increased serum lactate (HP:0002151)3.07188515
57Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.03890924
58Delayed CNS myelination (HP:0002188)3.01756997
59Cerebral palsy (HP:0100021)3.01638203
60Fat malabsorption (HP:0002630)2.97837519
61Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.97429530
62Type I transferrin isoform profile (HP:0003642)2.96806572
63Abnormality of nucleobase metabolism (HP:0010932)2.96379200
64* Lethargy (HP:0001254)2.93293328
65Abnormality of the intrinsic pathway (HP:0010989)2.86217563
66Rhabdomyolysis (HP:0003201)2.85443627
67Proximal tubulopathy (HP:0000114)2.83769742
68Abnormality of complement system (HP:0005339)2.80707099
69Microvesicular hepatic steatosis (HP:0001414)2.79875324
70Hypercholesterolemia (HP:0003124)2.77731462
71Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.72417557
72* Cerebral edema (HP:0002181)2.72301869
73Myopathic facies (HP:0002058)2.71541391
74Hyperbilirubinemia (HP:0002904)2.71455759
753-Methylglutaconic aciduria (HP:0003535)2.69111061
76Abnormality of pyrimidine metabolism (HP:0004353)2.63867141
77Increased purine levels (HP:0004368)2.61791246
78Hyperuricemia (HP:0002149)2.61791246
79Respiratory failure (HP:0002878)2.50286070
80* Vomiting (HP:0002013)2.49661104
81Hepatic necrosis (HP:0002605)2.48917115
82Skin nodule (HP:0200036)2.48114506
83Late onset (HP:0003584)2.47714620
84Emotional lability (HP:0000712)2.47000521
85Agammaglobulinemia (HP:0004432)2.40308850
86Muscle fiber atrophy (HP:0100295)2.37293766
87Exercise-induced myalgia (HP:0003738)2.34587179
88Hydroxyprolinuria (HP:0003080)2.33715891
89Abnormality of proline metabolism (HP:0010907)2.33715891
90Reduced antithrombin III activity (HP:0001976)2.31538068
91Nausea (HP:0002018)2.31394195
92Increased muscle lipid content (HP:0009058)2.31058485
93Hepatocellular carcinoma (HP:0001402)2.30499860
94Optic disc pallor (HP:0000543)2.29977438
95Cholelithiasis (HP:0001081)2.29023314
96Neonatal onset (HP:0003623)2.28909207
97Abnormal protein glycosylation (HP:0012346)2.27934755
98Abnormal glycosylation (HP:0012345)2.27934755
99Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.27934755
100Abnormal protein N-linked glycosylation (HP:0012347)2.27934755
101Steatorrhea (HP:0002570)2.26612397
102Abnormal number of erythroid precursors (HP:0012131)2.25839654
103Myocardial infarction (HP:0001658)2.25162112
104Hyperinsulinemic hypoglycemia (HP:0000825)2.24423155
105Type 2 muscle fiber atrophy (HP:0003554)2.23643703
106Hypoglycemic seizures (HP:0002173)2.23164988
107Vascular calcification (HP:0004934)2.22823083
108Exertional dyspnea (HP:0002875)2.22690716
109Conjugated hyperbilirubinemia (HP:0002908)2.22408211
110Abnormal gallbladder morphology (HP:0012437)2.22053348
111Spastic diplegia (HP:0001264)2.21763933
112Abnormal cartilage morphology (HP:0002763)2.18735792
113Aplastic anemia (HP:0001915)2.17662666
114Abnormality of urine glucose concentration (HP:0011016)2.11459319
115Glycosuria (HP:0003076)2.11459319
116Respiratory difficulties (HP:0002880)2.10296824
117Acute hepatic failure (HP:0006554)2.10122406
118Irritability (HP:0000737)2.08799721
119Palpitations (HP:0001962)2.08488210
120Malnutrition (HP:0004395)2.08458509
121Sensorimotor neuropathy (HP:0007141)2.05612375
122CNS demyelination (HP:0007305)2.04865527
123Acute encephalopathy (HP:0006846)2.04608848
124Pancytopenia (HP:0001876)2.02736234
125Progressive microcephaly (HP:0000253)2.02438217
126Sudden death (HP:0001699)2.02070274
127Abnormality of cells of the erythroid lineage (HP:0012130)2.01278384
128Right ventricular cardiomyopathy (HP:0011663)2.01051209
129Progressive muscle weakness (HP:0003323)1.99965020
130Systemic lupus erythematosus (HP:0002725)1.99812684
131Cardiovascular calcification (HP:0011915)1.99555195
132* Pancreatitis (HP:0001733)1.99135370
133Exercise-induced muscle cramps (HP:0003710)1.98392504
134Rimmed vacuoles (HP:0003805)1.97895111
135Brushfield spots (HP:0001088)1.97059581
136Decreased electroretinogram (ERG) amplitude (HP:0000654)1.96730174
137Reticulocytopenia (HP:0001896)1.96025605
138Cerebral hypomyelination (HP:0006808)1.95692863
139Ragged-red muscle fibers (HP:0003200)1.95497808
140Hypertriglyceridemia (HP:0002155)1.93264598
141Spastic paraparesis (HP:0002313)1.93074492
142Ventricular tachycardia (HP:0004756)1.91534702
143Alkalosis (HP:0001948)1.91098207
144Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.90962612
145Methylmalonic aciduria (HP:0012120)1.90746520
146Neck muscle weakness (HP:0000467)1.90407480
147Hyperglycemia (HP:0003074)1.87443482
148Esophageal varix (HP:0002040)1.85494425
149Renal cortical cysts (HP:0000803)1.84750193
150Centrally nucleated skeletal muscle fibers (HP:0003687)1.83449218
151Spontaneous abortion (HP:0005268)1.83390857
152Asymmetric septal hypertrophy (HP:0001670)1.82136131
153EMG: myopathic abnormalities (HP:0003458)1.81610128
154Muscle stiffness (HP:0003552)1.80911215
155Abnormality of reticulocytes (HP:0004312)1.80478972
156Atrioventricular block (HP:0001678)1.80162478
157Hyporeflexia of lower limbs (HP:0002600)1.77372194
158Cholecystitis (HP:0001082)1.76938282
159Abnormal gallbladder physiology (HP:0012438)1.76938282
160Opisthotonus (HP:0002179)1.76284989
161Hyperphosphaturia (HP:0003109)1.73425284
162Testicular atrophy (HP:0000029)1.73264957
163Reticulocytosis (HP:0001923)1.73114778
164IgG deficiency (HP:0004315)1.72965047
165Increased IgM level (HP:0003496)1.72089186
166Methylmalonic acidemia (HP:0002912)1.71227717
167Muscle hypertrophy of the lower extremities (HP:0008968)1.69882492
168Microretrognathia (HP:0000308)1.68567451
169Elevated erythrocyte sedimentation rate (HP:0003565)1.68460162

Predicted kinase interactions (KEA)

RankGene SetZ-score
1* BCKDK4.97000612
2TESK24.79492320
3TRIB34.20968438
4ERN14.04002437
5SIK13.55320119
6PKN23.55097350
7VRK23.45064995
8MAP4K23.33996743
9FGFR42.99196516
10PDK42.97900626
11PDK32.97900626
12TTN2.75312341
13PIM22.37404493
14TLK12.10923505
15FLT32.08301637
16LMTK21.90926281
17ARAF1.86486606
18PDK21.86350821
19TIE11.82571372
20INSRR1.81795213
21VRK11.80718907
22PINK11.80289943
23ZAK1.75663539
24WNK41.72825612
25TESK11.71132437
26PHKG11.64744484
27PHKG21.64744484
28STK161.62823566
29TXK1.61801739
30NEK11.61105554
31MAP2K31.59033923
32TNK21.56906381
33MYLK1.55159825
34OBSCN1.54421797
35CAMK1D1.50942828
36LIMK11.48061447
37CSNK1G31.45568052
38MAPK111.40225896
39PTK61.34571346
40TAOK31.28828648
41RPS6KA51.27108563
42MAP2K71.24349879
43PRKAA21.23934124
44MST1R1.22897270
45MAP3K71.22158186
46PIK3CG1.21587308
47KDR1.20571856
48DAPK11.20313682
49MAPKAPK51.17408207
50NME11.13853071
51DYRK21.13834575
52TRIM281.12794550
53MAPKAPK31.11869783
54EPHB11.11587758
55CDK191.10792398
56TGFBR21.08638434
57RIPK11.05359072
58MAP2K41.04118479
59CSNK1A1L1.00823569
60MAP3K31.00425938
61MAP3K101.00201795
62NUAK10.99223630
63TYK20.97621106
64AURKA0.97110225
65MAPK120.95583228
66ERBB40.95437647
67STK38L0.95385291
68CCNB10.94402176
69PRKAA10.94271450
70CSNK1G20.93633292
71ITK0.93163007
72EEF2K0.91524764
73NEK90.90369724
74SYK0.88385256
75IKBKB0.84970529
76LATS10.84686346
77CSNK1G10.84597833
78JAK20.84254414
79LRRK20.83329113
80WNK30.82991165
81PIK3CA0.79916558
82SRPK10.79410445
83ICK0.78580629
84TBK10.77408775
85ABL20.76770875
86CAMK1G0.73732912
87RAF10.72275830
88MAP3K110.72150602
89ATR0.71690961
90BTK0.71378269
91PDPK10.71005953
92FES0.70849701
93PRKCQ0.69352514
94MAP2K60.67664018
95PDGFRA0.66593896
96RPS6KA40.63183111
97PRKD10.61515919
98GRK60.60907518
99PRKACG0.60466315
100FGFR20.60142375
101MTOR0.59956524
102MET0.59735959
103MATK0.57140860
104NME20.55943606
105MAPK40.55841156
106IRAK30.55345828
107JAK10.55239152
108TAOK20.53946902
109LYN0.53675282
110IKBKE0.53580896
111DYRK1B0.53551960
112PDK10.52614257
113OXSR10.51055896
114SCYL20.50477857
115GSK3A0.49968690
116PBK0.49703792
117LCK0.49381458
118PAK30.45878984
119CSNK2A10.44674751
120KIT0.44269142
121MAP2K10.44187682
122MAP3K50.43426447
123MAP2K20.43091946
124CDK40.42322011
125RET0.40123427
126IRAK40.40113366
127CDK60.39297520
128CSF1R0.39040084
129ADRBK20.38989387
130PIM10.38631062
131CAMK2G0.38331168
132FGFR30.37790080
133* CSNK2A20.37699238
134SGK30.37591069
135CSNK1A10.37456153
136BRAF0.36974981
137PRKCZ0.36935809
138CDK70.36710112
139PRKCI0.35671705
140CAMK40.35402435
141MAP4K10.33645013
142ILK0.33588044
143ERBB20.33347276
144MAPK150.31433388
145DAPK30.30993424
146FRK0.30982580
147AKT20.30501998
148STK380.30195428
149PRKACA0.29921183
150DAPK20.29239538
151TGFBR10.29015686
152AURKB0.28294841
153RPS6KB20.28135043
154PKN10.27896976
155PTK20.26649173
156ZAP700.26309419
157CAMK2D0.26290591
158CSK0.26206862
159PAK10.26104493
160MAPK130.25693744
161MUSK0.25125823
162EPHA30.24761228
163MAP3K10.24371130
164MAPK70.23131044
165MAPK30.22953427

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.50575937
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.27444430
3Fatty acid degradation_Homo sapiens_hsa000713.15942743
4* Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.04512568
5Nitrogen metabolism_Homo sapiens_hsa009102.99751100
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.95646672
7* Propanoate metabolism_Homo sapiens_hsa006402.90001607
8Proteasome_Homo sapiens_hsa030502.85168696
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.84645557
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.77175202
11Arginine biosynthesis_Homo sapiens_hsa002202.67270508
12Tryptophan metabolism_Homo sapiens_hsa003802.57505335
13Fatty acid metabolism_Homo sapiens_hsa012122.42137781
14Butanoate metabolism_Homo sapiens_hsa006502.41928299
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.37023531
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.34826887
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.32528007
18Peroxisome_Homo sapiens_hsa041462.14387672
19PPAR signaling pathway_Homo sapiens_hsa033202.14108090
20Ribosome_Homo sapiens_hsa030102.09267621
21Base excision repair_Homo sapiens_hsa034102.05891713
22Pentose and glucuronate interconversions_Homo sapiens_hsa000402.00586899
23Pyruvate metabolism_Homo sapiens_hsa006201.97876442
24RNA polymerase_Homo sapiens_hsa030201.92210740
25Complement and coagulation cascades_Homo sapiens_hsa046101.91259238
26beta-Alanine metabolism_Homo sapiens_hsa004101.87833104
27Carbon metabolism_Homo sapiens_hsa012001.85503133
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.79117431
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.74114488
30Primary immunodeficiency_Homo sapiens_hsa053401.71888158
31DNA replication_Homo sapiens_hsa030301.71291557
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.68047542
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.52405383
34Biosynthesis of amino acids_Homo sapiens_hsa012301.51429600
35Pyrimidine metabolism_Homo sapiens_hsa002401.50601714
36Fatty acid elongation_Homo sapiens_hsa000621.50259851
37Chemical carcinogenesis_Homo sapiens_hsa052041.50233738
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.48947639
39Systemic lupus erythematosus_Homo sapiens_hsa053221.45885218
40Histidine metabolism_Homo sapiens_hsa003401.45625588
41Caffeine metabolism_Homo sapiens_hsa002321.45466035
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.45340640
43Phenylalanine metabolism_Homo sapiens_hsa003601.42001983
44Selenocompound metabolism_Homo sapiens_hsa004501.40721074
45Drug metabolism - other enzymes_Homo sapiens_hsa009831.38503303
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34455941
47Mismatch repair_Homo sapiens_hsa034301.34025088
48Starch and sucrose metabolism_Homo sapiens_hsa005001.32672509
49Sulfur metabolism_Homo sapiens_hsa009201.31693846
50Steroid hormone biosynthesis_Homo sapiens_hsa001401.30003097
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.28538959
52Autoimmune thyroid disease_Homo sapiens_hsa053201.26861662
53Allograft rejection_Homo sapiens_hsa053301.26679800
54Bile secretion_Homo sapiens_hsa049761.25829067
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.23938403
56Fat digestion and absorption_Homo sapiens_hsa049751.20156206
57Tyrosine metabolism_Homo sapiens_hsa003501.19961115
58Retinol metabolism_Homo sapiens_hsa008301.18627758
59Cyanoamino acid metabolism_Homo sapiens_hsa004601.15154225
60Folate biosynthesis_Homo sapiens_hsa007901.14215089
61Staphylococcus aureus infection_Homo sapiens_hsa051501.12749381
62Sulfur relay system_Homo sapiens_hsa041221.09382484
63Arginine and proline metabolism_Homo sapiens_hsa003301.08677185
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08499927
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.07606802
66Intestinal immune network for IgA production_Homo sapiens_hsa046721.06787001
67Purine metabolism_Homo sapiens_hsa002301.01868128
68Homologous recombination_Homo sapiens_hsa034401.00143081
69Fanconi anemia pathway_Homo sapiens_hsa034600.99533041
70Graft-versus-host disease_Homo sapiens_hsa053320.98369707
71Spliceosome_Homo sapiens_hsa030400.98328784
72Glycerolipid metabolism_Homo sapiens_hsa005610.95176747
73ABC transporters_Homo sapiens_hsa020100.94619655
74Lysine degradation_Homo sapiens_hsa003100.94340310
75Fatty acid biosynthesis_Homo sapiens_hsa000610.94036236
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91754607
77Protein export_Homo sapiens_hsa030600.91090775
78Asthma_Homo sapiens_hsa053100.87656316
79Nucleotide excision repair_Homo sapiens_hsa034200.85902614
80Type I diabetes mellitus_Homo sapiens_hsa049400.82521689
81Pentose phosphate pathway_Homo sapiens_hsa000300.81117739
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79095813
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76884385
84Glutathione metabolism_Homo sapiens_hsa004800.75601751
85Vitamin digestion and absorption_Homo sapiens_hsa049770.73947552
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73182942
87Vitamin B6 metabolism_Homo sapiens_hsa007500.71237565
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.67954422
89Viral myocarditis_Homo sapiens_hsa054160.60763150
90Alcoholism_Homo sapiens_hsa050340.59268828
91Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.58981106
92Antigen processing and presentation_Homo sapiens_hsa046120.58674269
93Fructose and mannose metabolism_Homo sapiens_hsa000510.56746203
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.56036307
95Steroid biosynthesis_Homo sapiens_hsa001000.55216197
96RNA degradation_Homo sapiens_hsa030180.53661683
97* Metabolic pathways_Homo sapiens_hsa011000.52696836
98Insulin resistance_Homo sapiens_hsa049310.51839450
99One carbon pool by folate_Homo sapiens_hsa006700.49143212
100Galactose metabolism_Homo sapiens_hsa000520.44892672
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44501869
102Epstein-Barr virus infection_Homo sapiens_hsa051690.39215297
103Non-homologous end-joining_Homo sapiens_hsa034500.37415881
104Rheumatoid arthritis_Homo sapiens_hsa053230.33145705
105AMPK signaling pathway_Homo sapiens_hsa041520.33141671
106Collecting duct acid secretion_Homo sapiens_hsa049660.32890641
107Glucagon signaling pathway_Homo sapiens_hsa049220.32680240
108RNA transport_Homo sapiens_hsa030130.30666397
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30456408
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28132101
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.24744856
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23770190
113Oxidative phosphorylation_Homo sapiens_hsa001900.23614239
114Parkinsons disease_Homo sapiens_hsa050120.22985991
115Insulin signaling pathway_Homo sapiens_hsa049100.17346044
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.17343158
117Prion diseases_Homo sapiens_hsa050200.13131045
118Linoleic acid metabolism_Homo sapiens_hsa005910.11690266
119Cardiac muscle contraction_Homo sapiens_hsa042600.08454596
120Alzheimers disease_Homo sapiens_hsa050100.05578497
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.04013919
122Regulation of autophagy_Homo sapiens_hsa04140-0.1227422
123Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1124687
124Dilated cardiomyopathy_Homo sapiens_hsa05414-0.1076431
125Other glycan degradation_Homo sapiens_hsa00511-0.1041661
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1016378
127Huntingtons disease_Homo sapiens_hsa05016-0.0983815
128Renin-angiotensin system_Homo sapiens_hsa04614-0.0902652
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410-0.0854307
130Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0827570
131Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0673926
132Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0576763
133Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0519447
134Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0300928
135Protein digestion and absorption_Homo sapiens_hsa04974-0.0287224
136Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0046533

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