BCKDK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The branched-chain alpha-ketoacid dehydrogenase complex (BCKD) is an important regulator of the valine, leucine, and isoleucine catabolic pathways. The protein encoded by this gene is found in the mitochondrion, where it phosphorylates and inactivates BCKD. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.73955917
2negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.78579686
3DNA deamination (GO:0045006)4.77625437
4SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.47099119
5DNA strand elongation (GO:0022616)4.35973805
6cotranslational protein targeting to membrane (GO:0006613)4.33175407
7protein targeting to ER (GO:0045047)4.33066373
8viral transcription (GO:0019083)4.32455948
9telomere maintenance via semi-conservative replication (GO:0032201)4.25094626
10DNA strand elongation involved in DNA replication (GO:0006271)4.24998545
11pentose-phosphate shunt (GO:0006098)4.23076938
12translational termination (GO:0006415)4.22820593
13deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.13779288
14establishment of protein localization to endoplasmic reticulum (GO:0072599)4.11982185
15protein localization to endoplasmic reticulum (GO:0070972)4.08827632
16pinocytosis (GO:0006907)4.06176135
17formation of translation preinitiation complex (GO:0001731)4.04309684
18translational elongation (GO:0006414)3.94743404
19NADPH regeneration (GO:0006740)3.90722166
20protein retention in ER lumen (GO:0006621)3.90423560
21IMP biosynthetic process (GO:0006188)3.87054030
22maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.86910460
23barbed-end actin filament capping (GO:0051016)3.82028791
24COPI coating of Golgi vesicle (GO:0048205)3.80562334
25Golgi transport vesicle coating (GO:0048200)3.80562334
26telomere maintenance via telomere lengthening (GO:0010833)3.73539574
27glucose catabolic process (GO:0006007)3.65835164
28nucleotide salvage (GO:0043173)3.61386545
29telomere maintenance via recombination (GO:0000722)3.61257430
30maturation of SSU-rRNA (GO:0030490)3.59823307
31translational initiation (GO:0006413)3.53685367
32ribosomal small subunit biogenesis (GO:0042274)3.52628013
33IMP metabolic process (GO:0046040)3.52551618
34translation (GO:0006412)3.52521626
35exocrine pancreas development (GO:0031017)3.49958930
36oxidative phosphorylation (GO:0006119)3.47414016
37pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.39856995
38DNA replication initiation (GO:0006270)3.38839446
39monosaccharide biosynthetic process (GO:0046364)3.37613031
40ribosomal large subunit biogenesis (GO:0042273)3.35906457
41viral life cycle (GO:0019058)3.31681189
42mitotic recombination (GO:0006312)3.29660075
43signal peptide processing (GO:0006465)3.29619617
44nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.26650228
45cellular protein complex disassembly (GO:0043624)3.24669645
46GDP-mannose metabolic process (GO:0019673)3.23333212
47purine nucleotide salvage (GO:0032261)3.21132203
48DNA unwinding involved in DNA replication (GO:0006268)3.20830071
49gluconeogenesis (GO:0006094)3.20822853
50UV protection (GO:0009650)3.19784207
51tricarboxylic acid cycle (GO:0006099)3.18299963
52peptidyl-arginine omega-N-methylation (GO:0035247)3.17188014
53glycolytic process (GO:0006096)3.16100876
54DNA replication checkpoint (GO:0000076)3.15607889
55nucleobase biosynthetic process (GO:0046112)3.15467519
56mitochondrial calcium ion transport (GO:0006851)3.15408068
57pentose metabolic process (GO:0019321)3.14086170
58pyrimidine-containing compound salvage (GO:0008655)3.13438351
59pyrimidine nucleoside salvage (GO:0043097)3.13438351
60ubiquinone biosynthetic process (GO:0006744)3.12864016
61quinone biosynthetic process (GO:1901663)3.12864016
62glucose 6-phosphate metabolic process (GO:0051156)3.09829136
63hexose biosynthetic process (GO:0019319)3.09134209
64negative regulation of myeloid cell apoptotic process (GO:0033033)3.08498080
654-hydroxyproline metabolic process (GO:0019471)3.07423516
66mitotic nuclear envelope reassembly (GO:0007084)3.06793197
67nuclear envelope reassembly (GO:0031468)3.06793197
68negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.03696772
69muscle filament sliding (GO:0030049)3.03264492
70actin-myosin filament sliding (GO:0033275)3.03264492
71response to peptidoglycan (GO:0032494)3.02964568
72spliceosomal snRNP assembly (GO:0000387)3.01270600
73cullin deneddylation (GO:0010388)3.00958676
74regulation of mammary gland epithelial cell proliferation (GO:0033599)2.96587141
75pseudouridine synthesis (GO:0001522)2.96483324
76pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.94771595
77mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.94618508
78regulation of mitochondrial translation (GO:0070129)2.93169142
79protein complex disassembly (GO:0043241)2.92613090
80nucleotide-excision repair, DNA gap filling (GO:0006297)2.92279217
81deoxyribonucleotide catabolic process (GO:0009264)2.91008657
82negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.90446824
832-deoxyribonucleotide biosynthetic process (GO:0009265)2.89629544
84deoxyribose phosphate biosynthetic process (GO:0046385)2.89629544
85telomere maintenance via telomerase (GO:0007004)2.89387458
86L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.89278036
87protein localization to kinetochore (GO:0034501)2.87988703
88protein deneddylation (GO:0000338)2.85739886
89nucleobase-containing small molecule interconversion (GO:0015949)2.82236660
90metallo-sulfur cluster assembly (GO:0031163)2.81816775
91iron-sulfur cluster assembly (GO:0016226)2.81816775
92ribonucleoprotein complex biogenesis (GO:0022613)2.81613447
93prostanoid biosynthetic process (GO:0046457)2.81553912
94prostaglandin biosynthetic process (GO:0001516)2.81553912
95regulation of superoxide anion generation (GO:0032928)2.81446063
96purine nucleobase biosynthetic process (GO:0009113)2.80870907
97deoxyribose phosphate catabolic process (GO:0046386)2.80660538
98macromolecular complex disassembly (GO:0032984)2.80182922
99protein targeting to membrane (GO:0006612)2.78249005
100peptidyl-histidine modification (GO:0018202)2.77251877
101oxaloacetate metabolic process (GO:0006107)2.76309793
102heart contraction (GO:0060047)2.76051272
103heart process (GO:0003015)2.76051272
104folic acid-containing compound biosynthetic process (GO:0009396)2.75809420
105NADH metabolic process (GO:0006734)2.73474306
106tricarboxylic acid metabolic process (GO:0072350)2.73442713
107proteasome assembly (GO:0043248)2.73213691
108nucleoside salvage (GO:0043174)2.71803437
109purine deoxyribonucleotide catabolic process (GO:0009155)2.71356240
110negative regulation of B cell apoptotic process (GO:0002903)2.70756834
111ATP synthesis coupled proton transport (GO:0015986)2.69916612
112energy coupled proton transport, down electrochemical gradient (GO:0015985)2.69916612
113RNA-dependent DNA replication (GO:0006278)2.69717102
114regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.68916290
115telomere organization (GO:0032200)2.68750832
116pyrimidine nucleotide catabolic process (GO:0006244)2.68230231
117attachment of spindle microtubules to kinetochore (GO:0008608)2.67877472
118telomere maintenance (GO:0000723)2.67845880
119transcription elongation from RNA polymerase III promoter (GO:0006385)2.67612593
120termination of RNA polymerase III transcription (GO:0006386)2.67612593
121protein maturation by protein folding (GO:0022417)2.66986085
122positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.66678206
123antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.66202613
124negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.65710147
125negative regulation of ligase activity (GO:0051352)2.65710147
126mitochondrial fusion (GO:0008053)2.65642033
127galactose catabolic process (GO:0019388)2.65361993
128anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.64275275
129proline biosynthetic process (GO:0006561)2.63727062
130CENP-A containing nucleosome assembly (GO:0034080)2.63060249
131establishment of viral latency (GO:0019043)2.61777957
132retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.61733670
133pteridine-containing compound biosynthetic process (GO:0042559)2.61495814
134nuclear-transcribed mRNA catabolic process (GO:0000956)2.61480381
135antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.58359687
136valine metabolic process (GO:0006573)2.58097835
137histone arginine methylation (GO:0034969)2.57841424
138transcription-coupled nucleotide-excision repair (GO:0006283)2.56510940
139ubiquinone metabolic process (GO:0006743)2.55499997
140endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.55434499
141tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.55376296
142RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.55376296
143regulation of nuclear cell cycle DNA replication (GO:0033262)2.54487732
144rRNA processing (GO:0006364)2.54354911
145chromatin remodeling at centromere (GO:0031055)2.51601585
146mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.49393167
147guanosine-containing compound biosynthetic process (GO:1901070)2.47947589
148positive regulation of triglyceride lipase activity (GO:0061365)2.44576536
149positive regulation of lipoprotein lipase activity (GO:0051006)2.44576536
150cellular metabolic compound salvage (GO:0043094)2.42442362
151base-excision repair, AP site formation (GO:0006285)2.42090811
152amino sugar catabolic process (GO:0046348)2.41813655
153fructose metabolic process (GO:0006000)2.41018771
154pyruvate metabolic process (GO:0006090)2.38726679
155peptidyl-arginine methylation (GO:0018216)2.38460599
156peptidyl-arginine N-methylation (GO:0035246)2.38460599
157fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.36793676
158glycosphingolipid catabolic process (GO:0046479)2.36299686
159cyclooxygenase pathway (GO:0019371)2.36100508
160regulation of release of cytochrome c from mitochondria (GO:0090199)2.35400964
161proline metabolic process (GO:0006560)2.34704374
162protein targeting to mitochondrion (GO:0006626)2.34623249
163hyaluronan catabolic process (GO:0030214)2.32835532
164peptidyl-proline hydroxylation (GO:0019511)2.32588065
165pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.32276393
166regulation of mitochondrial membrane potential (GO:0051881)2.32161509
1672-deoxyribonucleotide metabolic process (GO:0009394)2.31292199
168lipopolysaccharide biosynthetic process (GO:0009103)2.29847739
169pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.28226053
170purine nucleobase metabolic process (GO:0006144)2.27799229
171NADP metabolic process (GO:0006739)2.26708818
172regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.25356966
173AMP metabolic process (GO:0046033)2.24428380
174L-phenylalanine metabolic process (GO:0006558)2.24178740
175erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.24178740
176pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.24158868
177deoxyribose phosphate metabolic process (GO:0019692)2.21901996
178negative regulation of mitochondrion organization (GO:0010823)2.21137414
179protein localization to endosome (GO:0036010)2.21118738
180extracellular fibril organization (GO:0043206)2.20898809
181L-serine metabolic process (GO:0006563)2.19247445
182response to thyroid hormone (GO:0097066)2.18565393
183deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.17328198

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.84859379
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.06952478
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.84678580
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.35092244
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.12301848
6ETS1_20019798_ChIP-Seq_JURKAT_Human2.95027226
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.94519923
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.90589911
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.80863356
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.80530852
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.78431033
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.76475626
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.58887662
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.56929410
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.52883006
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.37715543
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.36994510
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.34205931
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.31156766
20RARG_19884340_ChIP-ChIP_MEFs_Mouse2.25560209
21LXR_22292898_ChIP-Seq_THP-1_Human2.15452709
22XRN2_22483619_ChIP-Seq_HELA_Human2.14712459
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.12185283
24VDR_23849224_ChIP-Seq_CD4+_Human2.11001566
25DCP1A_22483619_ChIP-Seq_HELA_Human2.09568643
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.08505242
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.06532046
28BP1_19119308_ChIP-ChIP_Hs578T_Human2.06136528
29TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.05554395
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.01451964
31ELK3_25401928_ChIP-Seq_HUVEC_Human1.96499102
32FOXP3_21729870_ChIP-Seq_TREG_Human1.96187367
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94674213
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.92449989
35* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.90726823
36GABP_19822575_ChIP-Seq_HepG2_Human1.90649072
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.87307821
38SRY_22984422_ChIP-ChIP_TESTIS_Rat1.84151168
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.80824367
40CIITA_25753668_ChIP-Seq_RAJI_Human1.79012815
41ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.77010651
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.75619789
43* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.70867698
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70803987
45TET1_21451524_ChIP-Seq_MESCs_Mouse1.70642930
46PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.68969862
47ZNF263_19887448_ChIP-Seq_K562_Human1.68692598
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.68010712
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.67678882
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.67056241
51TTF2_22483619_ChIP-Seq_HELA_Human1.64547229
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.63704358
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59272510
54* RACK7_27058665_Chip-Seq_MCF-7_Human1.58818366
55MYC_22102868_ChIP-Seq_BL_Human1.58278174
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.57887046
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.57474404
58* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.56886347
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.48766389
60BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.44129371
61MYCN_18555785_ChIP-Seq_MESCs_Mouse1.43385019
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42115831
63* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.41613941
64KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.41467767
65AR_21909140_ChIP-Seq_LNCAP_Human1.41406994
66TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41405605
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.40870170
68ELF1_20517297_ChIP-Seq_JURKAT_Human1.40744563
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.40117753
70* P68_20966046_ChIP-Seq_HELA_Human1.38654676
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.36778829
72ELK1_19687146_ChIP-ChIP_HELA_Human1.36551972
73* BCL6_27268052_Chip-Seq_Bcells_Human1.34632119
74KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32779137
75HIF1A_21447827_ChIP-Seq_MCF-7_Human1.31766073
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31709999
77SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30302196
78CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.29153030
79VDR_21846776_ChIP-Seq_THP-1_Human1.29122242
80SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28335206
81NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.28296770
82YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28204349
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27678579
84* SA1_27219007_Chip-Seq_ERYTHROID_Human1.27082007
85TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24034494
86CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22520383
87ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.22334320
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.22067001
89ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.21728097
90VDR_24763502_ChIP-Seq_THP-1_Human1.21519241
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.20014204
92TFEB_21752829_ChIP-Seq_HELA_Human1.19385771
93SPI1_23547873_ChIP-Seq_NB4_Human1.17831213
94NOTCH1_21737748_ChIP-Seq_TLL_Human1.17040335
95* BCOR_27268052_Chip-Seq_Bcells_Human1.17017981
96ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16111325
97CTCF_26484167_Chip-Seq_Bcells_Mouse1.15776072
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15447145
99IRF8_22096565_ChIP-ChIP_GC-B_Human1.14681284
100KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13990977
101UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13636341
102RXR_22158963_ChIP-Seq_LIVER_Mouse1.12922731
103STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12712938
104KDM5A_27292631_Chip-Seq_BREAST_Human1.11505990
105CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09551929
106CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08650665
107* FOXP1_21924763_ChIP-Seq_HESCs_Human1.08453700
108PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08380418
109TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08193033
110KDM2B_26808549_Chip-Seq_DND41_Human1.07977461
111SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07813502
112SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.07576830
113ELK1_22589737_ChIP-Seq_MCF10A_Human1.06620280
114ATF3_27146783_Chip-Seq_COLON_Human1.04964306
115TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04893929
116PPARA_22158963_ChIP-Seq_LIVER_Mouse1.04454586
117* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04408585
118DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04080893
119GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03896739
120SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03605904
121CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03356608
122RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03340027
123* MAF_26560356_Chip-Seq_TH2_Human1.03199738
124PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03155662
125CLOCK_20551151_ChIP-Seq_293T_Human1.02594789
126CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02482910
127DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02435235
128HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00365748
129IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99611691
130KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99494606
131TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98747222
132MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.94364503
133CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93710421
134GATA4_21415370_ChIP-Seq_HL-1_Mouse0.92731790
135CTCF_18555785_ChIP-Seq_MESCs_Mouse0.91724385
136NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.89130621
137* YY1_22570637_ChIP-Seq_MALME-3M_Human0.87100318
138CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85598524
139POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.85331609
140NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.84844062
141KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.83927875
142MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.83385856
143GATA2_22383799_ChIP-Seq_G1ME_Mouse0.82911898
144SCL_19346495_ChIP-Seq_HPC-7_Human0.81875681
145* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81515425
146MYC_18940864_ChIP-ChIP_HL60_Human0.78536012
147POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.78324624
148SOX2_18555785_ChIP-Seq_MESCs_Mouse0.77863699

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.48674458
2MP0003693_abnormal_embryo_hatching3.42448019
3MP0008260_abnormal_autophagy3.35018643
4MP0009840_abnormal_foam_cell3.32310008
5MP0000749_muscle_degeneration2.73605646
6MP0003191_abnormal_cellular_cholesterol2.73177982
7MP0004957_abnormal_blastocyst_morpholog2.63640645
8MP0009278_abnormal_bone_marrow2.56907250
9MP0003111_abnormal_nucleus_morphology2.51959510
10MP0010094_abnormal_chromosome_stability2.50109790
11MP0005220_abnormal_exocrine_pancreas2.46685153
12MP0004858_abnormal_nervous_system2.33178953
13MP0003646_muscle_fatigue2.33051695
14MP0006054_spinal_hemorrhage2.32407203
15MP0003077_abnormal_cell_cycle2.27937593
16MP0002396_abnormal_hematopoietic_system2.18633034
17MP0006036_abnormal_mitochondrial_physio2.18069268
18MP0000490_abnormal_crypts_of2.16599743
19MP0002837_dystrophic_cardiac_calcinosis2.15263248
20MP0004084_abnormal_cardiac_muscle2.13472454
21MP0003172_abnormal_lysosome_physiology2.03233774
22MP0003436_decreased_susceptibility_to1.89648154
23MP0004510_myositis1.87795844
24MP0000750_abnormal_muscle_regeneration1.86903536
25MP0003705_abnormal_hypodermis_morpholog1.85671931
26MP0008058_abnormal_DNA_repair1.85462849
27MP0000751_myopathy1.84700967
28MP0003075_altered_response_to1.80208133
29MP0005464_abnormal_platelet_physiology1.79756752
30MP0008007_abnormal_cellular_replicative1.73196774
31MP0001666_abnormal_nutrient_absorption1.71835181
32MP0005330_cardiomyopathy1.69167239
33MP0003123_paternal_imprinting1.63091116
34MP0004036_abnormal_muscle_relaxation1.61150926
35MP0004145_abnormal_muscle_electrophysio1.60381833
36MP0003566_abnormal_cell_adhesion1.59510600
37MP0004808_abnormal_hematopoietic_stem1.55731732
38MP0002269_muscular_atrophy1.55705146
39MP0003279_aneurysm1.54035815
40MP0001849_ear_inflammation1.49856765
41MP0005083_abnormal_biliary_tract1.48944426
42MP0003828_pulmonary_edema1.47730250
43MP0003186_abnormal_redox_activity1.46050989
44MP0003763_abnormal_thymus_physiology1.45514482
45MP0008932_abnormal_embryonic_tissue1.44753902
46MP0009379_abnormal_foot_pigmentation1.44704417
47MP0003567_abnormal_fetal_cardiomyocyte1.43578067
48MP0004147_increased_porphyrin_level1.40829623
49MP0002139_abnormal_hepatobiliary_system1.38936048
50MP0003221_abnormal_cardiomyocyte_apopto1.38787201
51MP0004215_abnormal_myocardial_fiber1.38185854
52MP0002106_abnormal_muscle_physiology1.36469620
53MP0004087_abnormal_muscle_fiber1.35493274
54MP0005257_abnormal_intraocular_pressure1.35067566
55* MP0004233_abnormal_muscle_weight1.33242732
56MP0002419_abnormal_innate_immunity1.32917139
57MP0003303_peritoneal_inflammation1.28268889
58MP0002693_abnormal_pancreas_physiology1.27769369
59MP0008057_abnormal_DNA_replication1.24661309
60MP0009333_abnormal_splenocyte_physiolog1.23467960
61MP0000759_abnormal_skeletal_muscle1.19850930
62MP0008438_abnormal_cutaneous_collagen1.19582719
63MP0005501_abnormal_skin_physiology1.16621680
64MP0005023_abnormal_wound_healing1.16605828
65MP0000678_abnormal_parathyroid_gland1.14706243
66MP0010630_abnormal_cardiac_muscle1.13921209
67MP0000747_muscle_weakness1.13747343
68MP0005584_abnormal_enzyme/coenzyme_acti1.11235393
69MP0001533_abnormal_skeleton_physiology1.10104840
70MP0005025_abnormal_response_to1.09584998
71MP0004272_abnormal_basement_membrane1.09045299
72MP0002877_abnormal_melanocyte_morpholog1.07654931
73MP0002019_abnormal_tumor_incidence1.07213344
74MP0005369_muscle_phenotype1.06282756
75MP0000313_abnormal_cell_death1.06193614
76MP0005385_cardiovascular_system_phenoty1.05835187
77MP0001544_abnormal_cardiovascular_syste1.05835187
78MP0001881_abnormal_mammary_gland1.05745472
79MP0005084_abnormal_gallbladder_morpholo1.05520036
80MP0001835_abnormal_antigen_presentation1.04684329
81MP0005319_abnormal_enzyme/_coenzyme1.03064159
82MP0001730_embryonic_growth_arrest1.02811129
83MP0000343_altered_response_to1.02502418
84MP0001873_stomach_inflammation1.01822131
85MP0002132_abnormal_respiratory_system1.01553898
86MP0005620_abnormal_muscle_contractility1.01043127
87MP0003453_abnormal_keratinocyte_physiol1.00227790
88MP0002796_impaired_skin_barrier0.99676911
89MP0000350_abnormal_cell_proliferation0.99318055
90MP0008469_abnormal_protein_level0.98557460
91MP0010030_abnormal_orbit_morphology0.98367967
92MP0003806_abnormal_nucleotide_metabolis0.98203692
93MP0002080_prenatal_lethality0.97802184
94MP0003300_gastrointestinal_ulcer0.95915554
95MP0003786_premature_aging0.95889281
96MP0002972_abnormal_cardiac_muscle0.94407152
97MP0001697_abnormal_embryo_size0.93541074
98MP0005670_abnormal_white_adipose0.91828158
99MP0009785_altered_susceptibility_to0.91585146
100MP0008004_abnormal_stomach_pH0.91331638
101MP0002722_abnormal_immune_system0.91315528
102MP0003656_abnormal_erythrocyte_physiolo0.90827055
103MP0009764_decreased_sensitivity_to0.90575326
104MP0005166_decreased_susceptibility_to0.89419550
105MP0001944_abnormal_pancreas_morphology0.89277611
106MP0002398_abnormal_bone_marrow0.87861852
107MP0000689_abnormal_spleen_morphology0.87321264
108MP0000858_altered_metastatic_potential0.87174778
109MP0000703_abnormal_thymus_morphology0.86938659
110MP0001853_heart_inflammation0.83487455
111MP0000681_abnormal_thyroid_gland0.82982372
112MP0005360_urolithiasis0.82782198
113MP0001542_abnormal_bone_strength0.82299734
114MP0000358_abnormal_cell_content/0.82218919
115MP0005671_abnormal_response_to0.81017896
116MP0002429_abnormal_blood_cell0.80184339
117MP0001661_extended_life_span0.79921947
118MP0002332_abnormal_exercise_endurance0.79597194
119MP0004043_abnormal_pH_regulation0.79519081
120MP0005390_skeleton_phenotype0.79183559
121MP0005075_abnormal_melanosome_morpholog0.79168836
122MP0004130_abnormal_muscle_cell0.78442868
123MP0010368_abnormal_lymphatic_system0.77703449
124MP0003984_embryonic_growth_retardation0.77538605
125MP0006035_abnormal_mitochondrial_morpho0.76413645
126MP0005165_increased_susceptibility_to0.76114013
127MP0000685_abnormal_immune_system0.76105361
128MP0002088_abnormal_embryonic_growth/wei0.76005797
129MP0003724_increased_susceptibility_to0.75316123
130MP0010352_gastrointestinal_tract_polyps0.75129561
131MP0005058_abnormal_lysosome_morphology0.74661020
132MP0001545_abnormal_hematopoietic_system0.74504604
133MP0005397_hematopoietic_system_phenotyp0.74504604
134MP0002638_abnormal_pupillary_reflex0.73901618
135MP0000013_abnormal_adipose_tissue0.73834894
136MP0000604_amyloidosis0.73796580
137MP0008775_abnormal_heart_ventricle0.73490084
138MP0001727_abnormal_embryo_implantation0.73438494
139MP0008874_decreased_physiological_sensi0.72991606
140MP0010155_abnormal_intestine_physiology0.72600931
141MP0005623_abnormal_meninges_morphology0.71945241
142MP0009643_abnormal_urine_homeostasis0.71815910
143MP0001986_abnormal_taste_sensitivity0.71572846
144MP0001764_abnormal_homeostasis0.71405810
145* MP0005375_adipose_tissue_phenotype0.71062439
146MP0001672_abnormal_embryogenesis/_devel0.70433966
147MP0005380_embryogenesis_phenotype0.70433966
148MP0002089_abnormal_postnatal_growth/wei0.70333245
149MP0005666_abnormal_adipose_tissue0.70311660
150MP0009763_increased_sensitivity_to0.70117841
151MP0002148_abnormal_hypersensitivity_rea0.69986120
152MP0000609_abnormal_liver_physiology0.68975400
153MP0001845_abnormal_inflammatory_respons0.67932357
154MP0005000_abnormal_immune_tolerance0.67590087
155* MP0000003_abnormal_adipose_tissue0.67472749
156MP0002822_catalepsy0.67232811
157MP0005621_abnormal_cell_physiology0.67116386
158MP0000767_abnormal_smooth_muscle0.66977151
159MP0005384_cellular_phenotype0.66831275
160MP0003329_amyloid_beta_deposits0.66379037

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.05191794
2Cholecystitis (HP:0001082)4.03632644
3Abnormal gallbladder physiology (HP:0012438)4.03632644
4Abnormality of glycolipid metabolism (HP:0010969)3.96250992
5Abnormality of liposaccharide metabolism (HP:0010968)3.96250992
6Abnormality of glycosphingolipid metabolism (HP:0004343)3.96250992
7Aplastic anemia (HP:0001915)3.77102455
8Hepatic necrosis (HP:0002605)3.67910118
9Myoglobinuria (HP:0002913)3.54473668
10Centrally nucleated skeletal muscle fibers (HP:0003687)3.54334248
11Abnormal number of erythroid precursors (HP:0012131)3.42240745
12Abnormality of cells of the erythroid lineage (HP:0012130)3.41088972
13Vertebral compression fractures (HP:0002953)3.35873384
14Hepatocellular necrosis (HP:0001404)3.33101061
15Distal lower limb muscle weakness (HP:0009053)3.23787306
16Rhabdomyolysis (HP:0003201)3.16455563
17Abnormal mitochondria in muscle tissue (HP:0008316)3.16033491
18Exercise-induced muscle cramps (HP:0003710)3.12925430
19Mitochondrial inheritance (HP:0001427)3.04905120
20Acute necrotizing encephalopathy (HP:0006965)3.04078164
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.00185507
22Decreased activity of mitochondrial respiratory chain (HP:0008972)3.00185507
23Type I transferrin isoform profile (HP:0003642)2.99351638
24Progressive muscle weakness (HP:0003323)2.94708315
25Increased CSF lactate (HP:0002490)2.91440825
26Muscle fiber inclusion bodies (HP:0100299)2.83307849
27Exercise intolerance (HP:0003546)2.81639355
28Thrombocytosis (HP:0001894)2.79144437
29Calf muscle hypertrophy (HP:0008981)2.77564787
30Myopathic facies (HP:0002058)2.76237222
31Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.75660653
32Increased muscle lipid content (HP:0009058)2.73375663
33Petechiae (HP:0000967)2.72663196
34Vacuolated lymphocytes (HP:0001922)2.71607963
35Birth length less than 3rd percentile (HP:0003561)2.71499235
36Generalized aminoaciduria (HP:0002909)2.71394545
37Rough bone trabeculation (HP:0100670)2.70324792
38Axonal loss (HP:0003447)2.69250061
39Aplasia/Hypoplasia of the sacrum (HP:0008517)2.68535891
40Abnormal protein glycosylation (HP:0012346)2.68172922
41Abnormal glycosylation (HP:0012345)2.68172922
42Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.68172922
43Abnormal protein N-linked glycosylation (HP:0012347)2.68172922
44Muscle hypertrophy of the lower extremities (HP:0008968)2.67913378
45Systemic lupus erythematosus (HP:0002725)2.67245027
46Hepatosplenomegaly (HP:0001433)2.67110609
47Achilles tendon contracture (HP:0001771)2.66489311
48Ventricular tachycardia (HP:0004756)2.65025450
49Nemaline bodies (HP:0003798)2.64729587
50Dysostosis multiplex (HP:0000943)2.63843560
51Subaortic stenosis (HP:0001682)2.60973891
52Abnormality of the left ventricular outflow tract (HP:0011103)2.60973891
53Exercise-induced myalgia (HP:0003738)2.59486664
54Increased serum lactate (HP:0002151)2.58844130
55Acute encephalopathy (HP:0006846)2.56365456
56Hypertensive crisis (HP:0100735)2.56060031
57Lactic acidosis (HP:0003128)2.55854831
58Abnormality of glycolysis (HP:0004366)2.54746643
59Lipoatrophy (HP:0100578)2.52395689
60Palpitations (HP:0001962)2.51834498
61Increased intramyocellular lipid droplets (HP:0012240)2.51480681
62Prolonged neonatal jaundice (HP:0006579)2.50358099
63Opisthotonus (HP:0002179)2.49982438
64Abnormality of the Achilles tendon (HP:0005109)2.48909004
65Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.48421646
66Abnormality of alanine metabolism (HP:0010916)2.48421646
67Hyperalaninemia (HP:0003348)2.48421646
68Purpura (HP:0000979)2.46438202
69Muscle stiffness (HP:0003552)2.37064646
70Abnormality of skeletal muscle fiber size (HP:0012084)2.36692957
71Generalized amyotrophy (HP:0003700)2.35759016
72Premature rupture of membranes (HP:0001788)2.30553513
73Loss of speech (HP:0002371)2.29235188
74Cholelithiasis (HP:0001081)2.29060111
75Oral leukoplakia (HP:0002745)2.28678940
76Pancytopenia (HP:0001876)2.28265037
77Type 1 muscle fiber predominance (HP:0003803)2.28229340
78Bulbar palsy (HP:0001283)2.27918152
79Progressive macrocephaly (HP:0004481)2.27316150
80Microretrognathia (HP:0000308)2.26499387
81Increased connective tissue (HP:0009025)2.24824709
82Testicular atrophy (HP:0000029)2.22419030
83Increased variability in muscle fiber diameter (HP:0003557)2.21185728
84Reduced antithrombin III activity (HP:0001976)2.20277090
85Dilated cardiomyopathy (HP:0001644)2.18895104
86Lipid accumulation in hepatocytes (HP:0006561)2.18839114
87Hypoplasia of the pons (HP:0012110)2.18590097
88Abnormality of polysaccharide metabolism (HP:0011012)2.18377512
89Abnormality of glycosaminoglycan metabolism (HP:0004371)2.18377512
90Abnormality of mucopolysaccharide metabolism (HP:0011020)2.18377512
91Neoplasm of head and neck (HP:0012288)2.17639928
92Esophageal neoplasm (HP:0100751)2.17639928
93Abnormality of macrophages (HP:0004311)2.17004227
94Increased serum pyruvate (HP:0003542)2.16846671
95Multiple enchondromatosis (HP:0005701)2.14183012
96Pallor (HP:0000980)2.11373676
97Dicarboxylic aciduria (HP:0003215)2.10343673
98Abnormality of dicarboxylic acid metabolism (HP:0010995)2.10343673
99Increased cerebral lipofuscin (HP:0011813)2.09816493
100Distal lower limb amyotrophy (HP:0008944)2.09483173
101Distal arthrogryposis (HP:0005684)2.08903288
102Ragged-red muscle fibers (HP:0003200)2.08082028
103Macrocytic anemia (HP:0001972)2.07447088
104Respiratory failure (HP:0002878)2.06396006
105Sudden death (HP:0001699)2.04882237
106Asymmetric septal hypertrophy (HP:0001670)2.04685811
107Trismus (HP:0000211)2.04172504
108Degeneration of anterior horn cells (HP:0002398)2.01230238
109Abnormality of the anterior horn cell (HP:0006802)2.01230238
110Increased hepatocellular lipid droplets (HP:0006565)2.01174797
111Ulnar deviation of the wrist (HP:0003049)2.00964658
112Respiratory difficulties (HP:0002880)2.00413992
113Exertional dyspnea (HP:0002875)1.99800838
114Conjunctival hamartoma (HP:0100780)1.97441360
115Calcaneovalgus deformity (HP:0001848)1.97281149
116Amyloidosis (HP:0011034)1.97083359
117Hypoglycemic coma (HP:0001325)1.95320691
118Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.95030546
119Hypokinesia (HP:0002375)1.94464968
120Carpal bone hypoplasia (HP:0001498)1.92890311
121Progressive neurologic deterioration (HP:0002344)1.92565682
122Abnormality of subcutaneous fat tissue (HP:0001001)1.92432258
123IgM deficiency (HP:0002850)1.92365679
124Abnormal gallbladder morphology (HP:0012437)1.92070014
125Mucopolysacchariduria (HP:0008155)1.91628896
126Urinary glycosaminoglycan excretion (HP:0003541)1.91628896
12711 pairs of ribs (HP:0000878)1.91414569
128EMG: myopathic abnormalities (HP:0003458)1.90729691
129Abnormal trabecular bone morphology (HP:0100671)1.90052361
130Bone marrow hypocellularity (HP:0005528)1.89055353
131Abnormality of the pons (HP:0007361)1.87649490
132Increased serum ferritin (HP:0003281)1.87600645
133Nausea (HP:0002018)1.86916285
134Abnormality of fatty-acid metabolism (HP:0004359)1.86841339
135Protrusio acetabuli (HP:0003179)1.85905695
136Absent thumb (HP:0009777)1.85772265
137Deformed tarsal bones (HP:0008119)1.85632297
138Upper motor neuron abnormality (HP:0002127)1.85607448
139Nuclear cataract (HP:0100018)1.84969173
140Cerebral palsy (HP:0100021)1.84578608
141Microvesicular hepatic steatosis (HP:0001414)1.83242397
142Myotonia (HP:0002486)1.82428934
143Abnormality of the tricuspid valve (HP:0001702)1.81046046
144Hyperacusis (HP:0010780)1.80959711
145Spinal rigidity (HP:0003306)1.80946735
146Obstructive lung disease (HP:0006536)1.80437748
147Chronic obstructive pulmonary disease (HP:0006510)1.80437748
148Premature graying of hair (HP:0002216)1.80436953
149Abnormality of the umbilical cord (HP:0010881)1.80431825
1503-Methylglutaconic aciduria (HP:0003535)1.80398461
151Cellulitis (HP:0100658)1.78394732
152Abnormality of T cell physiology (HP:0011840)1.78153040
153Myocardial infarction (HP:0001658)1.76161088
154Neck muscle weakness (HP:0000467)1.76074925
155Muscle fiber splitting (HP:0003555)1.75408161
156Easy fatigability (HP:0003388)1.75299603
157Abnormality of aromatic amino acid family metabolism (HP:0004338)1.74927004
158Upper limb amyotrophy (HP:0009129)1.74816676
159Distal upper limb amyotrophy (HP:0007149)1.74816676
160Increased neuronal autofluorescent lipopigment (HP:0002074)1.74405004
161Abnormality of the calf musculature (HP:0001430)1.72675907
162Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.72648370
163Maternal diabetes (HP:0009800)1.72537876
164Deep venous thrombosis (HP:0002625)1.72477427
165Abnormality of the preputium (HP:0100587)1.71598497
166Fatigue (HP:0012378)1.71465717
167Broad distal phalanx of finger (HP:0009836)1.71172105
168Abnormality of the gallbladder (HP:0005264)1.70590084

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.17065160
2NME23.79243468
3VRK23.07329550
4WEE12.75652834
5ARAF2.61391555
6STK162.49868025
7OBSCN2.45271959
8EIF2AK12.36962398
9* BCKDK2.34300977
10PASK2.33095150
11FLT32.29955671
12LIMK12.21860912
13BRSK22.20327237
14SMG12.19838471
15TLK12.13005376
16EIF2AK32.09023064
17MAP2K32.03804422
18TTN1.98553542
19NEK11.96697665
20PKN21.94881723
21ERN11.94282335
22ABL21.72032458
23MYLK1.66082241
24TRIB31.62673932
25PRPF4B1.60871575
26CDC71.48432827
27MAPKAPK31.47529991
28ZAP701.41994797
29CCNB11.39857713
30RPS6KB21.38576149
31KDR1.37522787
32ZAK1.34179733
33VRK11.30531391
34IRAK41.29868248
35NME11.28665020
36RPS6KA41.27788974
37CDK81.24046962
38KIT1.22065282
39EPHA21.21788794
40PDK41.18187444
41PDK31.18187444
42ICK1.17376932
43MOS1.17239236
44NEK21.13698776
45MUSK1.12754621
46TGFBR11.11803036
47PLK11.11095064
48ILK1.10681017
49AURKB1.09809861
50BTK1.07153746
51BRSK11.05565576
52SIK11.05470360
53PAK41.05101388
54SRPK11.04630224
55NEK91.04472513
56ACVR1B1.03873187
57DYRK31.01766794
58IRAK31.01148219
59MAP3K31.00361881
60EEF2K1.00353699
61PIK3CA0.99097558
62EPHB10.98058265
63PIM20.96149957
64PRKD20.96081716
65PIK3CG0.96079901
66MAP3K10.94047807
67LMTK20.91343743
68TESK20.90605768
69TSSK60.90604815
70TAOK10.90055850
71CSNK1G30.89596782
72PDK20.89249163
73TTK0.86871439
74DAPK10.86337452
75BLK0.85507532
76BRAF0.84508105
77STK40.83576634
78ATR0.82630286
79LRRK20.81788556
80MAP2K60.81021450
81CDK70.80701828
82GRK60.80655159
83PRKD30.77736496
84TEC0.77309378
85AURKA0.74007390
86MAP2K20.73612535
87SCYL20.70858404
88TIE10.69145890
89CDK40.68827067
90MAP3K110.67797269
91TBK10.66845912
92PTK20.65506230
93MKNK10.64048950
94JAK30.63770257
95MAP3K80.63763053
96AKT20.63652093
97RPS6KL10.63279132
98RPS6KC10.63279132
99RPS6KA60.62254563
100SIK30.61048810
101TYK20.59836976
102TAOK20.59273002
103TESK10.58696621
104PHKG20.57648065
105PHKG10.57648065
106DDR20.56857155
107MAP3K100.56136671
108CAMK2G0.55714802
109CSNK1A1L0.54919405
110RAF10.53840246
111CDK11A0.53428859
112MAP4K10.53216116
113PBK0.52382558
114CSNK2A10.52164797
115MKNK20.50889464
116PTK60.50305199
117CLK10.49539585
118CDK140.49459231
119CDK90.47976512
120CDK150.47790355
121DAPK30.45332670
122BMX0.44948450
123STK240.43662853
124CDK180.43225877
125PIM10.42299772
126MAPK110.41869979
127STK100.41328811
128MAPKAPK20.40049708
129RPS6KA50.38798873
130PRKCI0.38457967
131CSNK1G20.38043403
132PRKG20.37359948
133MAPKAPK50.36763682
134CSNK2A20.35855629
135TGFBR20.35617181
136PDPK10.35245431
137RPS6KA20.34569721
138CDK190.33276065
139MAPK120.33158177
140TRPM70.32588864
141IKBKE0.32439129
142PAK10.31488053
143PRKD10.31088824

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.18635915
2Ribosome_Homo sapiens_hsa030103.86465567
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.40576095
4Mismatch repair_Homo sapiens_hsa034303.34839080
5Protein export_Homo sapiens_hsa030603.26753264
6Proteasome_Homo sapiens_hsa030502.85914844
7Base excision repair_Homo sapiens_hsa034102.62216808
8Homologous recombination_Homo sapiens_hsa034402.39592505
9RNA polymerase_Homo sapiens_hsa030202.33000480
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.30712054
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.21330256
12Pyrimidine metabolism_Homo sapiens_hsa002402.08190892
13Spliceosome_Homo sapiens_hsa030402.08179323
14Nucleotide excision repair_Homo sapiens_hsa034202.04032540
15Fatty acid elongation_Homo sapiens_hsa000621.97371598
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.95698971
17Parkinsons disease_Homo sapiens_hsa050121.93953003
18One carbon pool by folate_Homo sapiens_hsa006701.82918945
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.82539699
20Oxidative phosphorylation_Homo sapiens_hsa001901.79288653
21RNA transport_Homo sapiens_hsa030131.72141331
22Lysosome_Homo sapiens_hsa041421.71099706
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.59191947
24Folate biosynthesis_Homo sapiens_hsa007901.57749509
25Cell cycle_Homo sapiens_hsa041101.54665646
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.52818358
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.50958325
28Fanconi anemia pathway_Homo sapiens_hsa034601.30398519
29Non-homologous end-joining_Homo sapiens_hsa034501.30103869
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.29776156
31Huntingtons disease_Homo sapiens_hsa050161.27291233
32Phenylalanine metabolism_Homo sapiens_hsa003601.26566397
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.26225307
34Carbon metabolism_Homo sapiens_hsa012001.26127923
35RNA degradation_Homo sapiens_hsa030181.23850433
36Purine metabolism_Homo sapiens_hsa002301.23425008
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22283154
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.21014638
39Alzheimers disease_Homo sapiens_hsa050101.18852403
40Pancreatic secretion_Homo sapiens_hsa049721.18850544
41Galactose metabolism_Homo sapiens_hsa000521.17422655
42N-Glycan biosynthesis_Homo sapiens_hsa005101.15143992
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.14091904
44Cyanoamino acid metabolism_Homo sapiens_hsa004601.13121209
45Other glycan degradation_Homo sapiens_hsa005111.13074329
46Fructose and mannose metabolism_Homo sapiens_hsa000511.06023101
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04561617
48Protein digestion and absorption_Homo sapiens_hsa049741.01446110
49Propanoate metabolism_Homo sapiens_hsa006400.98576125
50Central carbon metabolism in cancer_Homo sapiens_hsa052300.96568266
51Biosynthesis of amino acids_Homo sapiens_hsa012300.96482382
52Shigellosis_Homo sapiens_hsa051310.94415892
53Pentose phosphate pathway_Homo sapiens_hsa000300.93341267
54Legionellosis_Homo sapiens_hsa051340.89541301
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87077977
56p53 signaling pathway_Homo sapiens_hsa041150.86832022
57Antigen processing and presentation_Homo sapiens_hsa046120.86801504
58Cardiac muscle contraction_Homo sapiens_hsa042600.85305282
59Sulfur relay system_Homo sapiens_hsa041220.80913675
60Salmonella infection_Homo sapiens_hsa051320.79837637
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78596975
62Epstein-Barr virus infection_Homo sapiens_hsa051690.77283752
63Tyrosine metabolism_Homo sapiens_hsa003500.76781731
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74184067
65Fat digestion and absorption_Homo sapiens_hsa049750.73384685
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72206651
67Basal transcription factors_Homo sapiens_hsa030220.71556587
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71160955
69Vitamin B6 metabolism_Homo sapiens_hsa007500.71093604
70Prion diseases_Homo sapiens_hsa050200.70600934
71Pyruvate metabolism_Homo sapiens_hsa006200.70483141
72Staphylococcus aureus infection_Homo sapiens_hsa051500.69876544
73Fatty acid metabolism_Homo sapiens_hsa012120.66842367
74Sulfur metabolism_Homo sapiens_hsa009200.66362042
75Herpes simplex infection_Homo sapiens_hsa051680.64773024
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62263173
77Tuberculosis_Homo sapiens_hsa051520.61492875
78Phagosome_Homo sapiens_hsa041450.60766488
79Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58677624
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57349493
81mRNA surveillance pathway_Homo sapiens_hsa030150.56725955
82Complement and coagulation cascades_Homo sapiens_hsa046100.56555942
83Peroxisome_Homo sapiens_hsa041460.56019415
84Pertussis_Homo sapiens_hsa051330.56010026
85Viral myocarditis_Homo sapiens_hsa054160.53260838
86Arginine biosynthesis_Homo sapiens_hsa002200.52858160
87Arachidonic acid metabolism_Homo sapiens_hsa005900.51822870
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51512186
89Selenocompound metabolism_Homo sapiens_hsa004500.50672093
90Steroid biosynthesis_Homo sapiens_hsa001000.50202858
91Glutathione metabolism_Homo sapiens_hsa004800.49553411
92HTLV-I infection_Homo sapiens_hsa051660.48246911
93Metabolic pathways_Homo sapiens_hsa011000.47602759
94Primary immunodeficiency_Homo sapiens_hsa053400.47314181
95Renin-angiotensin system_Homo sapiens_hsa046140.45861135
96Apoptosis_Homo sapiens_hsa042100.45333900
97Thyroid cancer_Homo sapiens_hsa052160.44052299
98Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43992099
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41724302
100Viral carcinogenesis_Homo sapiens_hsa052030.41708648
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41178697
102Fatty acid degradation_Homo sapiens_hsa000710.40541731
103Toll-like receptor signaling pathway_Homo sapiens_hsa046200.39428569
104Rheumatoid arthritis_Homo sapiens_hsa053230.37889153
105Endocytosis_Homo sapiens_hsa041440.36698178
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36170605
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35660231
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32883344
109Glycosaminoglycan degradation_Homo sapiens_hsa005310.32869343
110Osteoclast differentiation_Homo sapiens_hsa043800.32708766
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32374115
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.32364603
113RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32100272
114Dilated cardiomyopathy_Homo sapiens_hsa054140.31873706
115Measles_Homo sapiens_hsa051620.31809898
116Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.31316322
117Influenza A_Homo sapiens_hsa051640.31224981
118PPAR signaling pathway_Homo sapiens_hsa033200.29037499
119HIF-1 signaling pathway_Homo sapiens_hsa040660.29021003
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.28858445
121Intestinal immune network for IgA production_Homo sapiens_hsa046720.28857132
122Notch signaling pathway_Homo sapiens_hsa043300.28622524
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28124306
124Systemic lupus erythematosus_Homo sapiens_hsa053220.27665657
125Regulation of autophagy_Homo sapiens_hsa041400.27654171
126Arginine and proline metabolism_Homo sapiens_hsa003300.25918509
127Small cell lung cancer_Homo sapiens_hsa052220.24017354
128Sphingolipid metabolism_Homo sapiens_hsa006000.23596298
129Leishmaniasis_Homo sapiens_hsa051400.23243743
130Starch and sucrose metabolism_Homo sapiens_hsa005000.22396387
131Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21613264
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20876165
133Acute myeloid leukemia_Homo sapiens_hsa052210.20724538
134Vibrio cholerae infection_Homo sapiens_hsa051100.20175224
135Bladder cancer_Homo sapiens_hsa052190.19044970

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