BCL11A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.83180987
2limb bud formation (GO:0060174)5.76377795
3pyrimidine nucleobase catabolic process (GO:0006208)5.51487126
4neural tube formation (GO:0001841)5.25005239
5definitive hemopoiesis (GO:0060216)5.06491932
6glial cell proliferation (GO:0014009)4.82916385
7regulation of timing of cell differentiation (GO:0048505)4.77223822
8presynaptic membrane organization (GO:0097090)4.60097800
9regulation of development, heterochronic (GO:0040034)4.53722503
10hindbrain development (GO:0030902)4.37256862
11nucleobase catabolic process (GO:0046113)4.35992376
12CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.31675213
13mRNA splice site selection (GO:0006376)4.29787178
14central nervous system neuron axonogenesis (GO:0021955)4.27939964
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.22626440
16positive regulation of response to oxidative stress (GO:1902884)4.14481159
17positive regulation of cellular response to oxidative stress (GO:1900409)4.14481159
18DNA double-strand break processing (GO:0000729)4.05199589
19cell migration in hindbrain (GO:0021535)4.04543983
20somite development (GO:0061053)3.89825124
21megakaryocyte development (GO:0035855)3.86698132
22T cell homeostasis (GO:0043029)3.84278013
23ionotropic glutamate receptor signaling pathway (GO:0035235)3.76872701
24cardiac chamber formation (GO:0003207)3.75552245
25negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.74327834
26negative regulation of translation, ncRNA-mediated (GO:0040033)3.74327834
27regulation of translation, ncRNA-mediated (GO:0045974)3.74327834
28inositol phosphate catabolic process (GO:0071545)3.72589017
29keratinocyte development (GO:0003334)3.68026837
30spinal cord development (GO:0021510)3.65245053
31kidney morphogenesis (GO:0060993)3.62737600
32positive regulation of protein homodimerization activity (GO:0090073)3.62502824
33G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.60869150
34sympathetic nervous system development (GO:0048485)3.60842381
35lung secretory cell differentiation (GO:0061140)3.60739464
36regulation of axon regeneration (GO:0048679)3.59760325
37regulation of neuron projection regeneration (GO:0070570)3.59760325
38protein localization to synapse (GO:0035418)3.52857136
39regulation of glutamate receptor signaling pathway (GO:1900449)3.52274696
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.48937518
41cornea development in camera-type eye (GO:0061303)3.48116510
42mitochondrial DNA replication (GO:0006264)3.44747237
43negative regulation of astrocyte differentiation (GO:0048712)3.42695186
44regulation of nuclear cell cycle DNA replication (GO:0033262)3.36171395
45DNA damage response, detection of DNA damage (GO:0042769)3.34913743
46neuron cell-cell adhesion (GO:0007158)3.34760389
47glutamate receptor signaling pathway (GO:0007215)3.33348129
48protein-cofactor linkage (GO:0018065)3.31724935
49olfactory bulb development (GO:0021772)3.30474257
50lymphoid progenitor cell differentiation (GO:0002320)3.29423703
51positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.28953589
52ribosomal small subunit assembly (GO:0000028)3.28469065
53behavioral response to nicotine (GO:0035095)3.27961630
54establishment of mitochondrion localization (GO:0051654)3.27846185
55positive regulation of gamma-delta T cell activation (GO:0046645)3.26508880
56transmission of nerve impulse (GO:0019226)3.23615757
57replication fork processing (GO:0031297)3.18485477
58positive regulation of dendritic spine morphogenesis (GO:0061003)3.16118417
59positive regulation of neurotransmitter secretion (GO:0001956)3.15041955
60gamma-aminobutyric acid transport (GO:0015812)3.13413939
61sialylation (GO:0097503)3.13221045
62glycosphingolipid biosynthetic process (GO:0006688)3.11281849
63vocalization behavior (GO:0071625)3.11107573
64T cell lineage commitment (GO:0002360)3.10516403
65negative regulation of transcription regulatory region DNA binding (GO:2000678)3.10123007
66neuron remodeling (GO:0016322)3.09747214
67embryonic hemopoiesis (GO:0035162)3.09741540
68positive regulation of amino acid transport (GO:0051957)3.05792882
69behavioral response to ethanol (GO:0048149)3.05078965
70G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.05058287
71* negative regulation of dendrite development (GO:2000171)3.01973598
72dopamine transport (GO:0015872)3.01883180
73central nervous system projection neuron axonogenesis (GO:0021952)2.99777955
74regulation of meiosis I (GO:0060631)2.98775057
75regulation of long-term neuronal synaptic plasticity (GO:0048169)2.95521501
76proline transport (GO:0015824)2.94849510
77protein localization to cilium (GO:0061512)2.94594180
78dentate gyrus development (GO:0021542)2.94247712
79negative regulation of type 2 immune response (GO:0002829)2.93501047
80regulation of regulatory T cell differentiation (GO:0045589)2.90659345
81forebrain neuron differentiation (GO:0021879)2.90011110
82L-fucose catabolic process (GO:0042355)2.89943795
83fucose catabolic process (GO:0019317)2.89943795
84L-fucose metabolic process (GO:0042354)2.89943795
85B cell receptor signaling pathway (GO:0050853)2.89011535
86positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.88776085
87long term synaptic depression (GO:0060292)2.88570738
88histone H3-K4 trimethylation (GO:0080182)2.87500539
89regulation of glutamate secretion (GO:0014048)2.86306342
90response to pheromone (GO:0019236)2.86014766
91positive regulation of CREB transcription factor activity (GO:0032793)2.83924754
92regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.83045156
93positive regulation of B cell differentiation (GO:0045579)2.83008301
94positive regulation of granulocyte differentiation (GO:0030854)2.82759014
95negative regulation of DNA binding (GO:0043392)2.82533631
96positive regulation of male gonad development (GO:2000020)2.82521925
97lymphocyte homeostasis (GO:0002260)2.82497653
98seminiferous tubule development (GO:0072520)2.80645272
99synaptic transmission, glutamatergic (GO:0035249)2.79902690
100regulation of telomere maintenance (GO:0032204)2.78361884
101positive regulation of action potential (GO:0045760)2.77892287
102regulation of synapse maturation (GO:0090128)2.77663304
103dendritic spine morphogenesis (GO:0060997)2.77386519
104postsynaptic membrane organization (GO:0001941)2.76681346
105cerebral cortex radially oriented cell migration (GO:0021799)2.76680565
106peptidyl-lysine trimethylation (GO:0018023)2.75099117
107germinal center formation (GO:0002467)2.74409884
108negative regulation of erythrocyte differentiation (GO:0045647)2.73003858
109leukocyte homeostasis (GO:0001776)2.72221176
110execution phase of apoptosis (GO:0097194)2.70769560
111tachykinin receptor signaling pathway (GO:0007217)2.70038565
112regulation of excitatory postsynaptic membrane potential (GO:0060079)2.69306852
113negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.69018032
114negative regulation of cell killing (GO:0031342)2.69018032
115exploration behavior (GO:0035640)2.67992457
116mitochondrion transport along microtubule (GO:0047497)2.67885220
117establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.67885220
118negative regulation of DNA-dependent DNA replication (GO:2000104)2.67807900
119energy homeostasis (GO:0097009)2.66744122
120positive regulation of protein sumoylation (GO:0033235)2.65749721
121positive regulation of cardiac muscle cell differentiation (GO:2000727)2.63953315
122pyrimidine-containing compound salvage (GO:0008655)2.63699141
123pyrimidine nucleoside salvage (GO:0043097)2.63699141
124presynaptic membrane assembly (GO:0097105)2.63655392
125axonal fasciculation (GO:0007413)2.63566251
126polyol catabolic process (GO:0046174)2.62644286
127detection of light stimulus involved in sensory perception (GO:0050962)2.62009677
128detection of light stimulus involved in visual perception (GO:0050908)2.62009677
129retinal cone cell development (GO:0046549)2.60915289
130inner ear receptor stereocilium organization (GO:0060122)2.60267007
131detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.58958070
132regulation of action potential (GO:0098900)2.58775622
133neuron recognition (GO:0008038)2.58681101
134startle response (GO:0001964)2.58318875
135regulation of dendritic spine development (GO:0060998)2.58266501
136locomotory exploration behavior (GO:0035641)2.57776499
137V(D)J recombination (GO:0033151)2.57615812
138regulation of pigment cell differentiation (GO:0050932)2.56755595
139adaptation of signaling pathway (GO:0023058)2.55926815
140aggressive behavior (GO:0002118)2.55826869
141maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.55305463
142embryonic epithelial tube formation (GO:0001838)2.55221286
143neuron-neuron synaptic transmission (GO:0007270)2.54605959
144regulation of erythrocyte differentiation (GO:0045646)2.52875045
145histone H3-K9 methylation (GO:0051567)2.52260160
146neurotransmitter-gated ion channel clustering (GO:0072578)2.51925271
147cell wall macromolecule catabolic process (GO:0016998)2.51300943
148* regulation of collateral sprouting (GO:0048670)2.51086790
149establishment of integrated proviral latency (GO:0075713)2.50691533
150regulation of histone H3-K27 methylation (GO:0061085)2.50573758
151regulation of short-term neuronal synaptic plasticity (GO:0048172)2.49415977
152maturation of SSU-rRNA (GO:0030490)2.48504895
153protein polyglutamylation (GO:0018095)2.48421856
154negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.48403198
155negative regulation of telomere maintenance (GO:0032205)2.47965440
156positive regulation of membrane potential (GO:0045838)2.47911377
157cardiac ventricle formation (GO:0003211)2.46726516
158dendrite morphogenesis (GO:0048813)2.46308025
159positive regulation of dendritic spine development (GO:0060999)2.46048412
160indolalkylamine metabolic process (GO:0006586)2.45960683
161regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.45285378
162positive regulation of DNA-dependent DNA replication (GO:2000105)2.45175119
163synaptic vesicle exocytosis (GO:0016079)2.44450496
164positive regulation of neurotransmitter transport (GO:0051590)2.43636099
165regulation of postsynaptic membrane potential (GO:0060078)2.42991884
166urogenital system development (GO:0001655)2.42835989
167histone H2A acetylation (GO:0043968)2.42732518
168positive regulation of synapse maturation (GO:0090129)2.42544463
169mast cell activation involved in immune response (GO:0002279)2.41318505
170mast cell degranulation (GO:0043303)2.41318505
171positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.41019068
172mature B cell differentiation involved in immune response (GO:0002313)2.40169367
173regulation of B cell differentiation (GO:0045577)2.39962726
174ganglioside metabolic process (GO:0001573)2.39430618
175regulation of dendritic spine morphogenesis (GO:0061001)2.38965208
176response to interleukin-15 (GO:0070672)2.37802048
177mature B cell differentiation (GO:0002335)2.37126744
178regulation of synaptic vesicle exocytosis (GO:2000300)2.36696480
179behavioral defense response (GO:0002209)2.36107132
180behavioral fear response (GO:0001662)2.36107132

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.39366920
2GBX2_23144817_ChIP-Seq_PC3_Human3.85172849
3SCL_19346495_ChIP-Seq_HPC-7_Human3.81539731
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.26093372
5RBPJ_22232070_ChIP-Seq_NCS_Mouse2.77545149
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.73004146
7VDR_22108803_ChIP-Seq_LS180_Human2.68480494
8* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.65680472
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.50023502
10TAF15_26573619_Chip-Seq_HEK293_Human2.44626771
11* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.06512445
12IGF1R_20145208_ChIP-Seq_DFB_Human2.04170360
13* EZH2_27304074_Chip-Seq_ESCs_Mouse1.98766350
14IKZF1_21737484_ChIP-ChIP_HCT116_Human1.98623467
15ZNF274_21170338_ChIP-Seq_K562_Hela1.98574015
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.95883516
17FUS_26573619_Chip-Seq_HEK293_Human1.92925257
18CIITA_25753668_ChIP-Seq_RAJI_Human1.92739742
19NOTCH1_21737748_ChIP-Seq_TLL_Human1.87385251
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.84689774
21SMAD_19615063_ChIP-ChIP_OVARY_Human1.82610613
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79392448
23* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.79138622
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78060436
25REST_21632747_ChIP-Seq_MESCs_Mouse1.73642816
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72549495
27* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.72081945
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.70366832
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.68920665
30* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67303830
31* P300_19829295_ChIP-Seq_ESCs_Human1.65659039
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64440740
33* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.61689837
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.61365118
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.60103788
36* RNF2_27304074_Chip-Seq_ESCs_Mouse1.59603472
37* MYC_22102868_ChIP-Seq_BL_Human1.58821301
38* EWS_26573619_Chip-Seq_HEK293_Human1.58111890
39* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.57987863
40* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.57201353
41* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.57201353
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.57092162
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.56509271
44* TP63_19390658_ChIP-ChIP_HaCaT_Human1.56020147
45* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.55481720
46IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.55305679
47* CBX2_27304074_Chip-Seq_ESCs_Mouse1.54864463
48* CBP_20019798_ChIP-Seq_JUKART_Human1.54615917
49* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54615917
50BCAT_22108803_ChIP-Seq_LS180_Human1.54106728
51* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54067216
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53440034
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.50196648
54* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.49673157
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49062831
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.44769592
57* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43941973
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43360850
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43343582
60* RUNX_20019798_ChIP-Seq_JUKART_Human1.42949451
61* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.42656291
62* RARB_27405468_Chip-Seq_BRAIN_Mouse1.40537959
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39960557
64* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38621815
65HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.36885685
66* TCF4_23295773_ChIP-Seq_U87_Human1.36277405
67GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.36160434
68* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35804644
69NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35393893
70LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34517719
71CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.34141720
72STAT3_23295773_ChIP-Seq_U87_Human1.33992441
73* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32590420
74IRF1_19129219_ChIP-ChIP_H3396_Human1.30782546
75RUNX2_22187159_ChIP-Seq_PCA_Human1.27723325
76* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.26784428
77* EZH2_27294783_Chip-Seq_ESCs_Mouse1.26525861
78PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25211212
79TCF4_22108803_ChIP-Seq_LS180_Human1.24202085
80* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.22708655
81GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21797768
82P53_22127205_ChIP-Seq_FIBROBLAST_Human1.21608106
83* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21232065
84* PRDM14_20953172_ChIP-Seq_ESCs_Human1.20936370
85* EED_16625203_ChIP-ChIP_MESCs_Mouse1.19558021
86* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18654160
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18103129
88TP53_22573176_ChIP-Seq_HFKS_Human1.17639445
89* RNF2_27304074_Chip-Seq_NSC_Mouse1.17404324
90* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17105011
91TCF7_22412390_ChIP-Seq_EML_Mouse1.16813165
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.16072697
93AR_25329375_ChIP-Seq_VCAP_Human1.15475116
94* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.14455362
95* SMAD4_21799915_ChIP-Seq_A2780_Human1.14191120
96* FLI1_21867929_ChIP-Seq_TH2_Mouse1.12691179
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11814752
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11814752
99REST_18959480_ChIP-ChIP_MESCs_Mouse1.11392522
100EST1_17652178_ChIP-ChIP_JURKAT_Human1.11092471
101IRF8_21731497_ChIP-ChIP_J774_Mouse1.10745644
102CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.10151377
103EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08520092
104MYC_18940864_ChIP-ChIP_HL60_Human1.08467369
105SOX2_19829295_ChIP-Seq_ESCs_Human1.08296123
106NANOG_19829295_ChIP-Seq_ESCs_Human1.08296123
107KDM2B_26808549_Chip-Seq_REH_Human1.07649374
108SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06969489
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06846242
110FLI1_27457419_Chip-Seq_LIVER_Mouse1.06480476
111LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05837182
112KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05289208
113RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.04798173
114* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04598557
115* GATA1_19941827_ChIP-Seq_MEL_Mouse1.04275786
116* SOX2_21211035_ChIP-Seq_LN229_Gbm1.03001894
117DROSHA_22980978_ChIP-Seq_HELA_Human1.02355956
118* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02333788
119FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.01804721
120EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01700537
121TAL1_26923725_Chip-Seq_HPCs_Mouse1.01385939
122VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01000511
123IRF8_22096565_ChIP-ChIP_GC-B_Human1.00186110
124NFE2_27457419_Chip-Seq_LIVER_Mouse0.99611374
125E2F1_18555785_Chip-Seq_ESCs_Mouse0.99429644
126EZH2_27294783_Chip-Seq_NPCs_Mouse0.98652937
127* SMAD4_21741376_ChIP-Seq_EPCs_Human0.97462841
128EGR1_19374776_ChIP-ChIP_THP-1_Human0.96615215
129TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95765520
130P53_22387025_ChIP-Seq_ESCs_Mouse0.95695505
131STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.95664050
132NANOG_18555785_Chip-Seq_ESCs_Mouse0.95657469
133SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.93832728
134JUN_21703547_ChIP-Seq_K562_Human0.93475556
135AR_21572438_ChIP-Seq_LNCaP_Human0.93407190
136HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.92073501
137ER_23166858_ChIP-Seq_MCF-7_Human0.88413408
138SOX9_26525672_Chip-Seq_HEART_Mouse0.88025309
139SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87955911
140TP53_16413492_ChIP-PET_HCT116_Human0.87457628
141* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87382995
142GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87297808
143E2F7_22180533_ChIP-Seq_HELA_Human0.87269213
144OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86123473
145TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.85982913
146* RING1B_27294783_Chip-Seq_NPCs_Mouse0.85945531

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.21141715
2MP0003880_abnormal_central_pattern4.08755391
3MP0003787_abnormal_imprinting3.74642788
4MP0002132_abnormal_respiratory_system3.04751253
5MP0001188_hyperpigmentation3.01963648
6MP0006292_abnormal_olfactory_placode3.00150214
7MP0005174_abnormal_tail_pigmentation2.81647300
8MP0003635_abnormal_synaptic_transmissio2.74920905
9MP0002396_abnormal_hematopoietic_system2.64814077
10MP0000516_abnormal_urinary_system2.38896120
11MP0005367_renal/urinary_system_phenotyp2.38896120
12MP0002063_abnormal_learning/memory/cond2.32932478
13MP0009745_abnormal_behavioral_response2.29765855
14MP0000569_abnormal_digit_pigmentation2.26027671
15MP0001835_abnormal_antigen_presentation2.13523051
16MP0005409_darkened_coat_color2.11945489
17MP0004808_abnormal_hematopoietic_stem2.08948333
18MP0001968_abnormal_touch/_nociception2.06464698
19MP0003121_genomic_imprinting2.05727642
20MP0001984_abnormal_olfaction2.03779328
21MP0004147_increased_porphyrin_level2.01899191
22MP0001177_atelectasis1.93088357
23MP0009379_abnormal_foot_pigmentation1.91563899
24MP0002736_abnormal_nociception_after1.91494967
25MP0005551_abnormal_eye_electrophysiolog1.90523583
26MP0003718_maternal_effect1.86988768
27MP0005075_abnormal_melanosome_morpholog1.86361563
28MP0002751_abnormal_autonomic_nervous1.86003875
29MP0004270_analgesia1.82973273
30MP0000015_abnormal_ear_pigmentation1.82076661
31MP0008789_abnormal_olfactory_epithelium1.81011181
32MP0002572_abnormal_emotion/affect_behav1.80529690
33MP0005646_abnormal_pituitary_gland1.69813464
34MP0002095_abnormal_skin_pigmentation1.68490407
35MP0005671_abnormal_response_to1.63626369
36MP0002064_seizures1.62294867
37MP0008872_abnormal_physiological_respon1.59531603
38MP0000778_abnormal_nervous_system1.58763019
39MP0002876_abnormal_thyroid_physiology1.55724011
40MP0008877_abnormal_DNA_methylation1.54105130
41MP0006072_abnormal_retinal_apoptosis1.48707358
42MP0001486_abnormal_startle_reflex1.47051418
43* MP0002398_abnormal_bone_marrow1.46352474
44MP0001800_abnormal_humoral_immune1.39666179
45MP0008995_early_reproductive_senescence1.39275071
46MP0000465_gastrointestinal_hemorrhage1.38304936
47MP0005645_abnormal_hypothalamus_physiol1.38278164
48MP0003122_maternal_imprinting1.36669811
49MP0004885_abnormal_endolymph1.36483917
50MP0002272_abnormal_nervous_system1.33144775
51MP0002557_abnormal_social/conspecific_i1.31535822
52MP0006276_abnormal_autonomic_nervous1.30456317
53MP0002938_white_spotting1.28799689
54MP0005423_abnormal_somatic_nervous1.28116568
55MP0004811_abnormal_neuron_physiology1.27636489
56MP0000681_abnormal_thyroid_gland1.27223359
57MP0004133_heterotaxia1.26962988
58MP0004742_abnormal_vestibular_system1.26569952
59MP0002102_abnormal_ear_morphology1.26058989
60MP0003828_pulmonary_edema1.23836235
61MP0004043_abnormal_pH_regulation1.22700606
62MP0002653_abnormal_ependyma_morphology1.22123326
63MP0001529_abnormal_vocalization1.21137598
64MP0005187_abnormal_penis_morphology1.20669794
65MP0001501_abnormal_sleep_pattern1.20222785
66MP0003119_abnormal_digestive_system1.18486146
67MP0002184_abnormal_innervation1.17328287
68MP0005253_abnormal_eye_physiology1.11538258
69MP0003567_abnormal_fetal_cardiomyocyte1.10646447
70MP0002452_abnormal_antigen_presenting1.10482248
71MP0000631_abnormal_neuroendocrine_gland1.08240972
72MP0002420_abnormal_adaptive_immunity1.07932000
73MP0004924_abnormal_behavior1.07756768
74MP0005386_behavior/neurological_phenoty1.07756768
75MP0009046_muscle_twitch1.06664446
76* MP0000716_abnormal_immune_system1.06434549
77MP0001819_abnormal_immune_cell1.06166081
78MP0002734_abnormal_mechanical_nocicepti1.05553943
79MP0002752_abnormal_somatic_nervous1.05132406
80MP0003943_abnormal_hepatobiliary_system1.04620938
81MP0002735_abnormal_chemical_nociception1.03422305
82MP0000955_abnormal_spinal_cord1.03188167
83MP0001905_abnormal_dopamine_level1.01121909
84MP0002067_abnormal_sensory_capabilities1.01018846
85MP0005084_abnormal_gallbladder_morpholo1.00706369
86MP0003861_abnormal_nervous_system0.99292435
87MP0004142_abnormal_muscle_tone0.98245825
88MP0000372_irregular_coat_pigmentation0.97655502
89MP0008569_lethality_at_weaning0.97597181
90MP0008875_abnormal_xenobiotic_pharmacok0.97412187
91MP0005195_abnormal_posterior_eye0.94918115
92MP0002723_abnormal_immune_serum0.94248542
93* MP0000703_abnormal_thymus_morphology0.93889889
94MP0002928_abnormal_bile_duct0.93130642
95MP0001440_abnormal_grooming_behavior0.92531918
96MP0003385_abnormal_body_wall0.92271625
97* MP0002429_abnormal_blood_cell0.92120551
98MP0003890_abnormal_embryonic-extraembry0.91677355
99MP0000689_abnormal_spleen_morphology0.91336898
100MP0000049_abnormal_middle_ear0.91321318
101MP0000647_abnormal_sebaceous_gland0.91259171
102MP0003698_abnormal_male_reproductive0.91247897
103MP0002249_abnormal_larynx_morphology0.90932593
104MP0002822_catalepsy0.90874260
105MP0001485_abnormal_pinna_reflex0.87224692
106MP0002733_abnormal_thermal_nociception0.86687949
107MP0001502_abnormal_circadian_rhythm0.85574132
108MP0001986_abnormal_taste_sensitivity0.85278223
109* MP0002722_abnormal_immune_system0.83632535
110MP0010094_abnormal_chromosome_stability0.83595846
111MP0002066_abnormal_motor_capabilities/c0.82969947
112MP0003755_abnormal_palate_morphology0.82570623
113MP0000538_abnormal_urinary_bladder0.82517819
114MP0005464_abnormal_platelet_physiology0.81457189
115MP0001970_abnormal_pain_threshold0.80145108
116MP0006054_spinal_hemorrhage0.79154779
117MP0003763_abnormal_thymus_physiology0.79119453
118MP0005389_reproductive_system_phenotype0.77751312
119MP0002282_abnormal_trachea_morphology0.77026144
120MP0002152_abnormal_brain_morphology0.76895896
121MP0002069_abnormal_eating/drinking_beha0.76602040
122MP0002160_abnormal_reproductive_system0.75833059
123MP0000026_abnormal_inner_ear0.75296254
124MP0002233_abnormal_nose_morphology0.75053294
125MP0001293_anophthalmia0.74901193
126MP0005000_abnormal_immune_tolerance0.74538625
127MP0000427_abnormal_hair_cycle0.74123745
128MP0002837_dystrophic_cardiac_calcinosis0.73665489
129MP0000534_abnormal_ureter_morphology0.73145865
130MP0000566_synostosis0.72822552
131MP0003879_abnormal_hair_cell0.71915148
132MP0002638_abnormal_pupillary_reflex0.71163038
133MP0000685_abnormal_immune_system0.70244741
134MP0008058_abnormal_DNA_repair0.69969595
135MP0010030_abnormal_orbit_morphology0.69961992
136MP0003632_abnormal_nervous_system0.68929779
137MP0004233_abnormal_muscle_weight0.68893957
138MP0003631_nervous_system_phenotype0.68800699
139MP0003938_abnormal_ear_development0.66396609
140MP0002882_abnormal_neuron_morphology0.66396132
141MP0005394_taste/olfaction_phenotype0.65019213
142MP0005499_abnormal_olfactory_system0.65019213
143MP0005025_abnormal_response_to0.64188879
144MP0001664_abnormal_digestion0.64138939
145MP0002234_abnormal_pharynx_morphology0.63651130
146MP0001545_abnormal_hematopoietic_system0.62503841
147MP0005397_hematopoietic_system_phenotyp0.62503841
148MP0005387_immune_system_phenotype0.61102317
149MP0001790_abnormal_immune_system0.61102317

Predicted human phenotypes

RankGene SetZ-score
1Progressive inability to walk (HP:0002505)5.88278942
2Volvulus (HP:0002580)4.51025845
3Absent frontal sinuses (HP:0002688)4.40235856
4Febrile seizures (HP:0002373)4.05784556
5* Abnormality of the heme biosynthetic pathway (HP:0010472)3.93974092
6Focal motor seizures (HP:0011153)3.91321791
7Inability to walk (HP:0002540)3.90745752
8Facial diplegia (HP:0001349)3.76087226
9Agammaglobulinemia (HP:0004432)3.60726603
10Abnormality of the labia minora (HP:0012880)3.58309771
11Pancreatic cysts (HP:0001737)3.43656193
12Protruding tongue (HP:0010808)3.40830312
13Absent speech (HP:0001344)3.33289638
14Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.30014362
15Acute lymphatic leukemia (HP:0006721)3.26861049
16Syringomyelia (HP:0003396)3.24649947
17Spinal cord lesions (HP:0100561)3.24649947
18Thyroiditis (HP:0100646)3.21085627
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.15228594
20Decreased activity of mitochondrial respiratory chain (HP:0008972)3.15228594
21Tented upper lip vermilion (HP:0010804)3.11615820
22Pancreatic fibrosis (HP:0100732)3.07454106
23Molar tooth sign on MRI (HP:0002419)3.02950320
24Abnormality of midbrain morphology (HP:0002418)3.02950320
25True hermaphroditism (HP:0010459)3.02483263
26Abnormality of B cell number (HP:0010975)3.01001364
27Stereotypic behavior (HP:0000733)2.97474769
28Epileptic encephalopathy (HP:0200134)2.96859608
29Ragged-red muscle fibers (HP:0003200)2.94829689
30B lymphocytopenia (HP:0010976)2.89970733
31Nephronophthisis (HP:0000090)2.88368435
32Hypochromic microcytic anemia (HP:0004840)2.81587437
33Aplastic anemia (HP:0001915)2.81277005
34Broad-based gait (HP:0002136)2.80341350
35Obsessive-compulsive behavior (HP:0000722)2.79879709
36Abnormality of the frontal sinuses (HP:0002687)2.75663930
37Hypoproteinemia (HP:0003075)2.72077299
38Hyperventilation (HP:0002883)2.71402427
39Reticulocytopenia (HP:0001896)2.67988855
40Mutism (HP:0002300)2.65274051
41IgM deficiency (HP:0002850)2.63748166
42Small hand (HP:0200055)2.62676431
43Congenital stationary night blindness (HP:0007642)2.60859726
44Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.60263237
45Neoplasm of the adrenal cortex (HP:0100641)2.59720687
46Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.59462624
47Inappropriate behavior (HP:0000719)2.58996582
48Abolished electroretinogram (ERG) (HP:0000550)2.55818850
49Weak cry (HP:0001612)2.52484040
50Abnormality of the renal medulla (HP:0100957)2.48206601
51Lissencephaly (HP:0001339)2.46516310
52Abnormal number of erythroid precursors (HP:0012131)2.46059988
53Chronic hepatic failure (HP:0100626)2.45255602
54Annular pancreas (HP:0001734)2.44243606
55Chromosomal breakage induced by crosslinking agents (HP:0003221)2.41551150
56Abnormal rod and cone electroretinograms (HP:0008323)2.39545837
57Amyotrophic lateral sclerosis (HP:0007354)2.39317990
58Abnormality of cells of the erythroid lineage (HP:0012130)2.36426787
59Cellulitis (HP:0100658)2.31121490
60Abnormality of DNA repair (HP:0003254)2.30336212
61Fair hair (HP:0002286)2.30051502
62Bile duct proliferation (HP:0001408)2.28261173
63Abnormal biliary tract physiology (HP:0012439)2.28261173
64Chromsome breakage (HP:0040012)2.26801459
65Patellar aplasia (HP:0006443)2.26096422
66Megalencephaly (HP:0001355)2.25730646
67Pendular nystagmus (HP:0012043)2.25169459
68Prolonged bleeding time (HP:0003010)2.22850376
69Ependymoma (HP:0002888)2.21770826
70Cystic liver disease (HP:0006706)2.21474763
71Focal seizures (HP:0007359)2.20381945
72Smooth philtrum (HP:0000319)2.20322278
73Visual hallucinations (HP:0002367)2.19917869
74Severe combined immunodeficiency (HP:0004430)2.19271436
75Stomach cancer (HP:0012126)2.18077478
76Type II lissencephaly (HP:0007260)2.16219785
77Aplasia/Hypoplasia of the patella (HP:0006498)2.13725578
78Renal hypoplasia (HP:0000089)2.13310210
79Colon cancer (HP:0003003)2.12910079
80Retinal dysplasia (HP:0007973)2.11866281
81Anencephaly (HP:0002323)2.11152510
82Abnormal hair whorl (HP:0010721)2.10965247
83Astrocytoma (HP:0009592)2.10511043
84Abnormality of the astrocytes (HP:0100707)2.10511043
85Recurrent bronchitis (HP:0002837)2.10356276
86Excessive salivation (HP:0003781)2.10276602
87Drooling (HP:0002307)2.10276602
88Medial flaring of the eyebrow (HP:0010747)2.09489875
89Dialeptic seizures (HP:0011146)2.08982147
90Limb dystonia (HP:0002451)2.06815714
91Cupped ear (HP:0000378)2.06461240
92Pachygyria (HP:0001302)2.04722108
93Generalized hypopigmentation of hair (HP:0011358)2.03392852
94Abnormality of the renal cortex (HP:0011035)2.03301992
95Progressive macrocephaly (HP:0004481)2.03028956
96Atonic seizures (HP:0010819)2.03005412
97Deeply set eye (HP:0000490)2.02847669
98Intellectual disability, progressive (HP:0006887)2.02075774
99Tubulointerstitial nephritis (HP:0001970)2.01947126
100Narrow forehead (HP:0000341)2.01080728
101Generalized tonic-clonic seizures (HP:0002069)2.00712933
102Clubbing of toes (HP:0100760)1.99921063
103Hepatoblastoma (HP:0002884)1.99674482
104Aplasia/Hypoplasia of the uvula (HP:0010293)1.98023766
105Widely spaced teeth (HP:0000687)1.97514140
106Glioma (HP:0009733)1.97148086
107Abnormality of the columella (HP:0009929)1.96636934
108Hemiparesis (HP:0001269)1.95934499
109Exotropia (HP:0000577)1.95829840
110Abnormality of the renal collecting system (HP:0004742)1.95467648
111Panhypogammaglobulinemia (HP:0003139)1.94502787
112Open mouth (HP:0000194)1.93268746
113Hypothermia (HP:0002045)1.92959557
114Nonprogressive disorder (HP:0003680)1.92668826
115Gait imbalance (HP:0002141)1.92032039
116Thin upper lip vermilion (HP:0000219)1.91150491
117Recurrent sinusitis (HP:0011108)1.89579601
118Optic nerve hypoplasia (HP:0000609)1.89369640
119Supernumerary bones of the axial skeleton (HP:0009144)1.88976750
120Impaired social interactions (HP:0000735)1.88835374
121Abnormal social behavior (HP:0012433)1.88835374
122Limb hypertonia (HP:0002509)1.88814290
123Meningitis (HP:0001287)1.88052211
124Abnormality of the fingertips (HP:0001211)1.87737686
125Renal cortical cysts (HP:0000803)1.86706292
126Poor eye contact (HP:0000817)1.86645715
127Tapered finger (HP:0001182)1.86627355
128Long clavicles (HP:0000890)1.85782257
129Sclerocornea (HP:0000647)1.84963661
130Progressive microcephaly (HP:0000253)1.84274378
131Gastrointestinal stroma tumor (HP:0100723)1.84193904
132Duplicated collecting system (HP:0000081)1.83315853
133Hyperacusis (HP:0010780)1.83208169
134Intellectual disability, severe (HP:0010864)1.82574835
135Type 2 muscle fiber atrophy (HP:0003554)1.82046627
136Chronic otitis media (HP:0000389)1.81911844
137Abnormal delayed hypersensitivity skin test (HP:0002963)1.81899513
138Dandy-Walker malformation (HP:0001305)1.81697125
139Myelodysplasia (HP:0002863)1.80998787
140Intestinal atresia (HP:0011100)1.80076750
141Abnormality of the parietal bone (HP:0002696)1.79989199
142Aplasia/Hypoplasia of the sternum (HP:0006714)1.78864416
143Thyroid-stimulating hormone excess (HP:0002925)1.78825080
144Abnormality of salivation (HP:0100755)1.77607903
145Heterochromia iridis (HP:0001100)1.77511631
146Absent rod-and cone-mediated responses on ERG (HP:0007688)1.76811482
147Attenuation of retinal blood vessels (HP:0007843)1.73635730
148Genital tract atresia (HP:0001827)1.73100325
149Abnormality of the intervertebral disk (HP:0005108)1.72910743
150Encephalitis (HP:0002383)1.71100796
151Methylmalonic acidemia (HP:0002912)1.71049680
152Lymphangioma (HP:0100764)1.71039952
153Myositis (HP:0100614)1.69907758
154Papilledema (HP:0001085)1.69889761
155Renal Fanconi syndrome (HP:0001994)1.68776146
156* Pallor (HP:0000980)1.68646319
157Postaxial hand polydactyly (HP:0001162)1.68102559
158Vaginal atresia (HP:0000148)1.67633403
159Male pseudohermaphroditism (HP:0000037)1.66958647
160Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.66079983
161Macroglossia (HP:0000158)1.65184870
162Myokymia (HP:0002411)1.64360074
163Autism (HP:0000717)1.63938940
164Chronic sinusitis (HP:0011109)1.61608154
165Lymphopenia (HP:0001888)1.60469593
166Gaze-evoked nystagmus (HP:0000640)1.60443504
167Acute myeloid leukemia (HP:0004808)1.60347860
168Thrombocytosis (HP:0001894)1.60167986
169Petechiae (HP:0000967)1.60151671
170Polyphagia (HP:0002591)1.59635737
171Progressive cerebellar ataxia (HP:0002073)1.55685164
172Increased number of teeth (HP:0011069)1.55626251
173Short philtrum (HP:0000322)1.55486789
174Neutropenia (HP:0001875)1.55439125

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.85175307
2WNK34.41489580
3TNIK3.43591168
4BMPR23.31805423
5EPHA42.95266163
6RIPK42.89423662
7MAP3K122.85631332
8MAP2K72.59052597
9MAPK132.51638276
10MARK12.47982963
11MAP4K22.34052256
12TIE12.29799090
13CASK2.20474539
14CDK192.19025765
15MKNK22.09569514
16NUAK12.05686685
17PLK22.04034481
18SIK22.01932264
19NTRK31.94711491
20PINK11.89081022
21BRSK21.85887456
22KIT1.85591519
23BCR1.77957126
24SYK1.77429533
25CCNB11.68289432
26FGFR31.67426164
27NTRK21.66087781
28MUSK1.64484836
29MKNK11.62596081
30TRIM281.59924889
31DAPK11.58294317
32SIK31.52019082
33FES1.50372438
34MAP4K11.41568996
35BMPR1B1.40799933
36BLK1.38805567
37MAP3K41.38647556
38DYRK1A1.31855612
39PIK3CA1.27665212
40INSRR1.25088147
41EEF2K1.24626296
42GRK11.23215699
43CLK11.22325186
44PNCK1.20910218
45ERBB31.20012428
46MINK11.19706746
47DYRK31.15426913
48ZAK1.14073078
49CSNK1G31.08758977
50CSF1R1.08286935
51CSNK1G10.98785292
52UHMK10.98531714
53FGR0.95701580
54FLT30.95241914
55BRSK10.93611564
56CSNK1A1L0.92876212
57PRKCZ0.90887204
58CAMK10.88755463
59CDK50.88326505
60MATK0.86998716
61BCKDK0.86096864
62GRK60.84405557
63MAPK120.83299437
64CAMKK20.83136697
65PRKCG0.83128858
66CDC70.83068204
67SRPK10.82974581
68BTK0.80276212
69TGFBR10.77927383
70OXSR10.77104976
71TEC0.71468169
72VRK10.70596223
73IKBKE0.67698454
74PRKCE0.67594078
75SGK30.66685258
76PHKG20.65559158
77PHKG10.65559158
78CSNK1A10.65447804
79MAPKAPK50.62707741
80HIPK20.62082400
81IRAK40.61801033
82SGK20.61549248
83MAP3K90.61167583
84DAPK20.60066420
85CDK80.59986985
86PAK30.59848115
87STK110.59100617
88IRAK20.59042591
89NEK60.58743826
90CDK90.58366428
91LYN0.57325152
92ACVR1B0.57318897
93TAOK10.57136950
94CSNK1D0.55789618
95YES10.55681765
96GRK70.55408258
97MAP2K40.55071100
98JAK30.54656670
99ADRBK10.54348566
100PLK10.54038048
101ATR0.54008083
102MARK20.53713867
103PLK30.53597792
104CAMKK10.53597391
105ADRBK20.53332498
106RPS6KA40.52994198
107RPS6KB10.50863809
108DYRK20.50816251
109TGFBR20.49972218
110PRKD20.49074011
111PRPF4B0.48563560
112TAOK30.48316343
113PLK40.47578780
114TLK10.47042488
115CAMK40.46024173
116MARK30.45711579
117MAPK70.45009630
118BUB10.44523392
119HCK0.43854692
120RPS6KA60.43813359
121TNK20.42249288
122BRD40.41545630
123EPHB20.40274696
124MAPK40.40027762
125PDK10.39864017
126PKN10.39289809
127FGFR20.38973691
128GRK50.37023523
129IRAK10.36820451
130CSNK1G20.35633248
131TXK0.35457957
132CDK30.35325512
133ATM0.35070826
134STK160.34793777
135KSR10.34688100
136IKBKB0.34628730
137CAMK2A0.34046763
138WNK40.34004262
139PAK60.33753049
140CAMK2B0.33510669
141EIF2AK30.33264035
142MAPK80.33011634
143VRK20.32984064
144PRKG10.32877185
145STK390.32319007
146ABL10.31946932
147PRKACA0.31820239
148CDK140.31374388
149PRKCB0.29327274
150CDK180.28726594
151SGK4940.28426359
152SGK2230.28426359

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.91712931
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.68812005
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.31128030
4Circadian entrainment_Homo sapiens_hsa047132.30575544
5Olfactory transduction_Homo sapiens_hsa047402.28465986
6Long-term potentiation_Homo sapiens_hsa047202.27813119
7Glutamatergic synapse_Homo sapiens_hsa047242.12211281
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.04532070
9Taste transduction_Homo sapiens_hsa047422.01386308
10Morphine addiction_Homo sapiens_hsa050321.89899113
11Butanoate metabolism_Homo sapiens_hsa006501.82685422
12Linoleic acid metabolism_Homo sapiens_hsa005911.79967678
13Amphetamine addiction_Homo sapiens_hsa050311.79752900
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74575055
15Asthma_Homo sapiens_hsa053101.69902669
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.68807663
17B cell receptor signaling pathway_Homo sapiens_hsa046621.64441292
18Ether lipid metabolism_Homo sapiens_hsa005651.64094618
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.63927275
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.61055289
21Dopaminergic synapse_Homo sapiens_hsa047281.60220950
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.59047828
23Steroid biosynthesis_Homo sapiens_hsa001001.59008864
24Primary immunodeficiency_Homo sapiens_hsa053401.55363483
25GABAergic synapse_Homo sapiens_hsa047271.54902224
26Salivary secretion_Homo sapiens_hsa049701.54157083
27Serotonergic synapse_Homo sapiens_hsa047261.52275087
28Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.52012012
29Oxidative phosphorylation_Homo sapiens_hsa001901.51453108
30Calcium signaling pathway_Homo sapiens_hsa040201.47098050
31Long-term depression_Homo sapiens_hsa047301.44471094
32Non-small cell lung cancer_Homo sapiens_hsa052231.43714114
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.41221415
34Parkinsons disease_Homo sapiens_hsa050121.39859600
35Ribosome_Homo sapiens_hsa030101.38477373
36Cholinergic synapse_Homo sapiens_hsa047251.30693751
37Renin secretion_Homo sapiens_hsa049241.30456895
38Caffeine metabolism_Homo sapiens_hsa002321.28899646
39Propanoate metabolism_Homo sapiens_hsa006401.26855522
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.26363345
41Oxytocin signaling pathway_Homo sapiens_hsa049211.23850213
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.20479340
43Selenocompound metabolism_Homo sapiens_hsa004501.17706386
44Non-homologous end-joining_Homo sapiens_hsa034501.13428909
45Base excision repair_Homo sapiens_hsa034101.10383059
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09629403
47Gastric acid secretion_Homo sapiens_hsa049711.09042453
48Synaptic vesicle cycle_Homo sapiens_hsa047211.09003697
49Neurotrophin signaling pathway_Homo sapiens_hsa047221.07864474
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07739560
51Mismatch repair_Homo sapiens_hsa034301.06655638
52Intestinal immune network for IgA production_Homo sapiens_hsa046721.06185128
53Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05997889
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05278318
55Pyrimidine metabolism_Homo sapiens_hsa002401.04649014
56Spliceosome_Homo sapiens_hsa030401.04234958
57African trypanosomiasis_Homo sapiens_hsa051431.01893748
58DNA replication_Homo sapiens_hsa030301.01544080
59SNARE interactions in vesicular transport_Homo sapiens_hsa041301.00822997
60RNA degradation_Homo sapiens_hsa030181.00726056
61Tryptophan metabolism_Homo sapiens_hsa003801.00713590
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98986808
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98499797
64Protein export_Homo sapiens_hsa030600.98399656
65ErbB signaling pathway_Homo sapiens_hsa040120.97672555
66GnRH signaling pathway_Homo sapiens_hsa049120.97070561
67Platelet activation_Homo sapiens_hsa046110.94492396
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94486625
69Insulin secretion_Homo sapiens_hsa049110.94257790
70Glioma_Homo sapiens_hsa052140.94104732
71Axon guidance_Homo sapiens_hsa043600.92707915
72cAMP signaling pathway_Homo sapiens_hsa040240.91699146
73Hepatitis B_Homo sapiens_hsa051610.91641000
74Hematopoietic cell lineage_Homo sapiens_hsa046400.88490800
75Alzheimers disease_Homo sapiens_hsa050100.84673897
76Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84044623
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83822878
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82099542
79Cocaine addiction_Homo sapiens_hsa050300.81701558
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.81313906
81Acute myeloid leukemia_Homo sapiens_hsa052210.79996934
82Melanogenesis_Homo sapiens_hsa049160.79028332
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78827249
84Gap junction_Homo sapiens_hsa045400.78769453
85Fanconi anemia pathway_Homo sapiens_hsa034600.78723474
86Alcoholism_Homo sapiens_hsa050340.77793838
87Choline metabolism in cancer_Homo sapiens_hsa052310.77782608
88Oocyte meiosis_Homo sapiens_hsa041140.77765734
89Colorectal cancer_Homo sapiens_hsa052100.77698817
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76805489
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.76535012
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.75986968
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74893219
94Chemical carcinogenesis_Homo sapiens_hsa052040.74348139
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74066627
96T cell receptor signaling pathway_Homo sapiens_hsa046600.73458813
97Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72986731
98Nitrogen metabolism_Homo sapiens_hsa009100.72881434
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.72583939
100Wnt signaling pathway_Homo sapiens_hsa043100.72064726
101MAPK signaling pathway_Homo sapiens_hsa040100.71509618
102Homologous recombination_Homo sapiens_hsa034400.70811580
103Collecting duct acid secretion_Homo sapiens_hsa049660.70784848
104Measles_Homo sapiens_hsa051620.70662814
105Herpes simplex infection_Homo sapiens_hsa051680.70543366
106Basal transcription factors_Homo sapiens_hsa030220.68688140
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67889967
108Huntingtons disease_Homo sapiens_hsa050160.66837070
109Phototransduction_Homo sapiens_hsa047440.66740023
110Chemokine signaling pathway_Homo sapiens_hsa040620.65495954
111Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64465323
112VEGF signaling pathway_Homo sapiens_hsa043700.64386168
113Arachidonic acid metabolism_Homo sapiens_hsa005900.63920594
114Type I diabetes mellitus_Homo sapiens_hsa049400.63443226
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62910379
116Purine metabolism_Homo sapiens_hsa002300.62621189
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62270136
118RNA transport_Homo sapiens_hsa030130.61039445
119Allograft rejection_Homo sapiens_hsa053300.58419989
120Osteoclast differentiation_Homo sapiens_hsa043800.58311506
121Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.58154853
122Autoimmune thyroid disease_Homo sapiens_hsa053200.58018453
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.57725823
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56278043
125Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55513539
126Cardiac muscle contraction_Homo sapiens_hsa042600.55487825
127NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55169595
128Tuberculosis_Homo sapiens_hsa051520.54402891
129Proteasome_Homo sapiens_hsa030500.54307797
130Inositol phosphate metabolism_Homo sapiens_hsa005620.54017352
131Thyroid cancer_Homo sapiens_hsa052160.53286998
132Estrogen signaling pathway_Homo sapiens_hsa049150.53274665
133Graft-versus-host disease_Homo sapiens_hsa053320.53237112
134Retinol metabolism_Homo sapiens_hsa008300.52514928
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51374743
136Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51118585
137MicroRNAs in cancer_Homo sapiens_hsa052060.50690660
138Ras signaling pathway_Homo sapiens_hsa040140.50372228
139Shigellosis_Homo sapiens_hsa051310.49594281
140Influenza A_Homo sapiens_hsa051640.48868690
141Peroxisome_Homo sapiens_hsa041460.48257017
142Chronic myeloid leukemia_Homo sapiens_hsa052200.48008389
143Regulation of autophagy_Homo sapiens_hsa041400.47849662
144Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47388847
145RNA polymerase_Homo sapiens_hsa030200.45911028
146Phospholipase D signaling pathway_Homo sapiens_hsa040720.45105645
147Hedgehog signaling pathway_Homo sapiens_hsa043400.44725329
148ABC transporters_Homo sapiens_hsa020100.41708078
149Ovarian steroidogenesis_Homo sapiens_hsa049130.41419979
150Primary bile acid biosynthesis_Homo sapiens_hsa001200.36135761
151Melanoma_Homo sapiens_hsa052180.33941323
152Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31155047
153Fat digestion and absorption_Homo sapiens_hsa049750.30962723
154Type II diabetes mellitus_Homo sapiens_hsa049300.29983718
155Metabolic pathways_Homo sapiens_hsa011000.29490384
156Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29200458

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