BCL11B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.72842258
2positive regulation of granulocyte differentiation (GO:0030854)5.23441092
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.20234503
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.13784454
5negative regulation of cell killing (GO:0031342)5.13784454
6ionotropic glutamate receptor signaling pathway (GO:0035235)5.05915787
7regulation of B cell receptor signaling pathway (GO:0050855)4.97225649
8response to interleukin-15 (GO:0070672)4.91601502
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.90256684
10vocalization behavior (GO:0071625)4.89335577
11tolerance induction (GO:0002507)4.83617304
12regulation of gamma-delta T cell differentiation (GO:0045586)4.74554135
13positive thymic T cell selection (GO:0045059)4.72295314
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.65278887
15regulation of short-term neuronal synaptic plasticity (GO:0048172)4.60352146
16regulation of glutamate receptor signaling pathway (GO:1900449)4.59360539
17protein localization to synapse (GO:0035418)4.54644382
18positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.51508331
19locomotory exploration behavior (GO:0035641)4.49846196
20leukocyte aggregation (GO:0070486)4.47906782
21glutamate receptor signaling pathway (GO:0007215)4.45526663
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.44994722
23regulation of gamma-delta T cell activation (GO:0046643)4.34894448
24regulation of isotype switching to IgG isotypes (GO:0048302)4.33238914
25antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.32051291
26neuron cell-cell adhesion (GO:0007158)4.28535257
27T cell migration (GO:0072678)4.25814144
28G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)4.21334948
29regulation of synapse structural plasticity (GO:0051823)4.13599997
30negative regulation of T cell mediated immunity (GO:0002710)4.11673377
31* alpha-beta T cell differentiation (GO:0046632)4.11258799
32negative T cell selection (GO:0043383)4.10604391
33regulation of dendritic spine morphogenesis (GO:0061001)4.09607187
34regulation of neuronal synaptic plasticity (GO:0048168)4.09306878
35exploration behavior (GO:0035640)4.05911779
36interferon-gamma production (GO:0032609)4.00121847
37dendritic spine morphogenesis (GO:0060997)3.99870957
38antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.97142265
39synaptic transmission, glutamatergic (GO:0035249)3.94315695
40synaptic vesicle maturation (GO:0016188)3.91528795
41neural tube formation (GO:0001841)3.91324796
42neuron-neuron synaptic transmission (GO:0007270)3.88993985
43positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.88724954
44long-term memory (GO:0007616)3.87009893
45neuron recognition (GO:0008038)3.86059462
46adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.85977910
47synaptic vesicle exocytosis (GO:0016079)3.85173092
48regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.81730107
49antigen processing and presentation of endogenous antigen (GO:0019883)3.81547467
50phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.80534302
51synaptic transmission, dopaminergic (GO:0001963)3.79518595
52regulation of excitatory postsynaptic membrane potential (GO:0060079)3.79113091
53histone H3-K4 trimethylation (GO:0080182)3.75501164
54mucosal-associated lymphoid tissue development (GO:0048537)3.75280984
55Peyers patch development (GO:0048541)3.75280984
56behavioral fear response (GO:0001662)3.74910103
57behavioral defense response (GO:0002209)3.74910103
58regulation of alpha-beta T cell proliferation (GO:0046640)3.68465270
59regulation of T cell tolerance induction (GO:0002664)3.68458310
60* T cell differentiation (GO:0030217)3.67989321
61CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.64039384
62T-helper cell differentiation (GO:0042093)3.64039384
63negative regulation of lymphocyte mediated immunity (GO:0002707)3.61663190
64neurotransmitter-gated ion channel clustering (GO:0072578)3.61184934
65* alpha-beta T cell activation (GO:0046631)3.60225123
66T cell differentiation involved in immune response (GO:0002292)3.57079524
67alpha-beta T cell differentiation involved in immune response (GO:0002293)3.57079524
68alpha-beta T cell activation involved in immune response (GO:0002287)3.57079524
69prepulse inhibition (GO:0060134)3.56908735
70regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.56817353
71layer formation in cerebral cortex (GO:0021819)3.56650244
72positive regulation of dendritic spine morphogenesis (GO:0061003)3.55044422
73negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.53455791
74negative regulation of translation, ncRNA-mediated (GO:0040033)3.53455791
75regulation of translation, ncRNA-mediated (GO:0045974)3.53455791
76positive regulation of synapse maturation (GO:0090129)3.53358618
77regulation of female receptivity (GO:0045924)3.53342376
78regulation of postsynaptic membrane potential (GO:0060078)3.47718909
79negative regulation of protein oligomerization (GO:0032460)3.47206801
80histone H3-K36 demethylation (GO:0070544)3.47088342
81dopamine receptor signaling pathway (GO:0007212)3.47009874
82axonal fasciculation (GO:0007413)3.46968636
83regulation of synaptic plasticity (GO:0048167)3.46225611
84positive regulation of alpha-beta T cell proliferation (GO:0046641)3.45617306
85negative thymic T cell selection (GO:0045060)3.45204869
86positive regulation of membrane potential (GO:0045838)3.44784295
87* positive T cell selection (GO:0043368)3.44156661
88CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.43113351
89regulation of synaptic vesicle exocytosis (GO:2000300)3.41780956
90* T cell selection (GO:0045058)3.41410453
91response to histamine (GO:0034776)3.39265538
92regulation of dendritic spine development (GO:0060998)3.38569196
93positive regulation of tolerance induction (GO:0002645)3.38045747
94long-term synaptic potentiation (GO:0060291)3.37629767
95fear response (GO:0042596)3.36436490
96neuronal action potential propagation (GO:0019227)3.36404099
97response to amphetamine (GO:0001975)3.36306729
98regulation of regulatory T cell differentiation (GO:0045589)3.35986909
99activated T cell proliferation (GO:0050798)3.34295914
100antigen receptor-mediated signaling pathway (GO:0050851)3.34132943
101positive regulation of neurotransmitter secretion (GO:0001956)3.34018667
102transmission of nerve impulse (GO:0019226)3.33328733
103signal complex assembly (GO:0007172)3.31751515
104positive regulation of synaptic transmission, GABAergic (GO:0032230)3.31170727
105regulation of granulocyte differentiation (GO:0030852)3.29916443
106T cell homeostasis (GO:0043029)3.27708090
107regulation of interleukin-2 biosynthetic process (GO:0045076)3.26501002
108positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.24985880
109glutamate secretion (GO:0014047)3.22661328
110synaptic vesicle docking involved in exocytosis (GO:0016081)3.22561925
111negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.20458133
112thymic T cell selection (GO:0045061)3.17584476
113membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.17183096
114dendritic spine organization (GO:0097061)3.15946281
115behavioral response to cocaine (GO:0048148)3.15885311
116neurotransmitter secretion (GO:0007269)3.14901998
117regulation of glutamate secretion (GO:0014048)3.14769550
118positive regulation of neurotransmitter transport (GO:0051590)3.14580838
119gamma-aminobutyric acid signaling pathway (GO:0007214)3.14176079
120striatum development (GO:0021756)3.13763893
121positive regulation of dendritic spine development (GO:0060999)3.12161148
122female mating behavior (GO:0060180)3.12010991
123regulation of synaptic transmission, glutamatergic (GO:0051966)3.10918362
124regulation of synaptic vesicle transport (GO:1902803)3.09685427
125learning (GO:0007612)3.09608314
126G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.09420900
127regulation of tolerance induction (GO:0002643)3.09302758
128substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.09053403
129substrate-independent telencephalic tangential migration (GO:0021826)3.09053403
130central nervous system projection neuron axonogenesis (GO:0021952)3.08725801
131negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.07861368
132regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.03020329
133postsynaptic membrane organization (GO:0001941)3.02632557
134cAMP catabolic process (GO:0006198)3.02053087
135regulation of B cell differentiation (GO:0045577)3.01402676
136regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.98293084
137positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.98293084
138positive regulation of T cell differentiation in thymus (GO:0033089)2.96437689
139auditory behavior (GO:0031223)2.95775499
140positive regulation of interleukin-2 production (GO:0032743)2.95615522
141cellular response to interleukin-15 (GO:0071350)2.93624923
142positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.93475545
143regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.93475545
144negative regulation of leukocyte mediated immunity (GO:0002704)2.93416716
145CD4-positive, alpha-beta T cell activation (GO:0035710)2.92622242
146gamma-aminobutyric acid transport (GO:0015812)2.92007695
147negative regulation of cAMP-mediated signaling (GO:0043951)2.91471571
148lymph node development (GO:0048535)2.90716584
149dendrite morphogenesis (GO:0048813)2.90614891
150regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.90597720
151histone H4-K16 acetylation (GO:0043984)2.90588131
152presynaptic membrane assembly (GO:0097105)2.90112653
153negative regulation of synaptic transmission, GABAergic (GO:0032229)2.90074486
154mast cell activation (GO:0045576)2.89718033
155glycosphingolipid biosynthetic process (GO:0006688)2.89490220
156negative regulation of adaptive immune response (GO:0002820)2.88807056
157regulation of T cell receptor signaling pathway (GO:0050856)2.87453450
158positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.87415238
159* T cell activation (GO:0042110)2.86984855
160mast cell activation involved in immune response (GO:0002279)2.85439175
161mast cell degranulation (GO:0043303)2.85439175
162positive regulation of mRNA catabolic process (GO:0061014)2.84830641
163dentate gyrus development (GO:0021542)2.83615637
164membrane depolarization (GO:0051899)2.82814734
165B cell receptor signaling pathway (GO:0050853)2.81762529
166neuromuscular process controlling balance (GO:0050885)2.81189241
167regulation of vesicle fusion (GO:0031338)2.81000411
168T cell receptor signaling pathway (GO:0050852)2.79990169
169phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.79014574
170regulation of natural killer cell mediated immunity (GO:0002715)2.78486058
171regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.78486058
172cytoplasmic mRNA processing body assembly (GO:0033962)2.77894601
173regulation of Rap GTPase activity (GO:0032317)2.77216692
174histone H3-K4 methylation (GO:0051568)2.75895899
175natural killer cell differentiation (GO:0001779)2.75733883
176positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.75632337
177positive regulation of CREB transcription factor activity (GO:0032793)2.74010283
178histone H3-K9 modification (GO:0061647)2.73308658
179negative regulation of glial cell proliferation (GO:0060253)2.71095588
180* lymphocyte differentiation (GO:0030098)2.70417028
181negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.68908610
182negative regulation of T-helper cell differentiation (GO:0045623)2.68908610
183regulation of mRNA catabolic process (GO:0061013)2.68231207
184peptidyl-lysine trimethylation (GO:0018023)2.67362625
185protein K11-linked deubiquitination (GO:0035871)2.67047330
186regulation of alpha-beta T cell activation (GO:0046634)2.66681388
187positive regulation of isotype switching (GO:0045830)2.64820622
188negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.64133818

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.49341027
2* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.25654565
3GBX2_23144817_ChIP-Seq_PC3_Human3.10159015
4* RARB_27405468_Chip-Seq_BRAIN_Mouse3.02175483
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.96221552
6* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.90344023
7* MYB_26560356_Chip-Seq_TH2_Human2.73646525
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.69584374
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.69584374
10* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.64324197
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.64104098
12* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58432780
13* BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.57945570
14* EZH2_27304074_Chip-Seq_ESCs_Mouse2.53704200
15* REST_21632747_ChIP-Seq_MESCs_Mouse2.53062177
16AR_21572438_ChIP-Seq_LNCaP_Human2.51647985
17DROSHA_22980978_ChIP-Seq_HELA_Human2.48434075
18* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42676116
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.37511011
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.35616221
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.33858451
22* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.33367342
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.33202868
24* RNF2_27304074_Chip-Seq_ESCs_Mouse2.29480881
25* EZH2_27294783_Chip-Seq_ESCs_Mouse2.23187238
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.16916322
27* MYB_26560356_Chip-Seq_TH1_Human2.16882108
28IKZF1_21737484_ChIP-ChIP_HCT116_Human2.15460262
29* GATA3_27048872_Chip-Seq_THYMUS_Human2.15397765
30MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.12140117
31EED_16625203_ChIP-ChIP_MESCs_Mouse2.07541544
32* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.02303560
33SCL_19346495_ChIP-Seq_HPC-7_Human2.01801997
34RUNX1_17652178_ChIP-ChIP_JURKAT_Human2.01312826
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.00108125
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.97050312
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.92036198
38* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.86477187
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.82797775
40IGF1R_20145208_ChIP-Seq_DFB_Human1.82105455
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.81336426
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.80453389
43TAF15_26573619_Chip-Seq_HEK293_Human1.80088970
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.78304259
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.77417168
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.76913995
47VDR_24787735_ChIP-Seq_THP-1_Human1.72573484
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.70484077
49* UTX_26944678_Chip-Seq_JUKART_Human1.69890878
50* MAF_26560356_Chip-Seq_TH1_Human1.65524583
51MYC_22102868_ChIP-Seq_BL_Human1.65321645
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63050226
53IRF8_21731497_ChIP-ChIP_J774_Mouse1.60821137
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.59907122
55* GATA3_26560356_Chip-Seq_TH2_Human1.58563519
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57508024
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53682343
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53584932
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52623157
60IRF8_27001747_Chip-Seq_BMDM_Mouse1.51778738
61SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.50121610
62SMAD4_21799915_ChIP-Seq_A2780_Human1.44683864
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.42046643
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40935588
65* RING1B_27294783_Chip-Seq_ESCs_Mouse1.40326966
66P300_19829295_ChIP-Seq_ESCs_Human1.39519944
67* PRDM14_20953172_ChIP-Seq_ESCs_Human1.36657053
68CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.35425088
69NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35392842
70DNAJC2_21179169_ChIP-ChIP_NT2_Human1.34614959
71RBPJ_22232070_ChIP-Seq_NCS_Mouse1.34353368
72MAF_26560356_Chip-Seq_TH2_Human1.34265155
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.33220867
74* RING1B_27294783_Chip-Seq_NPCs_Mouse1.32911550
75WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31419578
76E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28911998
77* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.28726697
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.28685221
79CIITA_25753668_ChIP-Seq_RAJI_Human1.27900603
80* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23292784
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23265520
82ELF1_17652178_ChIP-ChIP_JURKAT_Human1.22107627
83ER_23166858_ChIP-Seq_MCF-7_Human1.21433313
84* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21431953
85TCF7_22412390_ChIP-Seq_EML_Mouse1.21012738
86BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20063480
87AR_25329375_ChIP-Seq_VCAP_Human1.18068022
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18065579
89ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17145500
90NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16868757
91SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16294517
92RUNX_20019798_ChIP-Seq_JUKART_Human1.16178993
93* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.15476483
94KDM2B_26808549_Chip-Seq_K562_Human1.14797133
95RNF2_27304074_Chip-Seq_NSC_Mouse1.14672743
96ERG_21242973_ChIP-ChIP_JURKAT_Human1.13065339
97KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12223223
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11157217
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10591908
100AHR_22903824_ChIP-Seq_MCF-7_Human1.10441909
101ARNT_22903824_ChIP-Seq_MCF-7_Human1.10322341
102PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09961522
103STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09793090
104* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09634347
105* AR_19668381_ChIP-Seq_PC3_Human1.09469974
106SOX2_21211035_ChIP-Seq_LN229_Gbm1.09386790
107FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.08816390
108* FLI1_21867929_ChIP-Seq_TH2_Mouse1.08581590
109* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08058347
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07491156
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07491156
112RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06489304
113* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06471222
114TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06219111
115STAT3_23295773_ChIP-Seq_U87_Human1.03991227
116POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03682980
117* KDM2B_26808549_Chip-Seq_JURKAT_Human1.03357602
118VDR_22108803_ChIP-Seq_LS180_Human1.03116705
119OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02097551
120RUNX1_22412390_ChIP-Seq_EML_Mouse1.01334888
121NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01237034
122CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00800664
123* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00680468
124* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00178649
125* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99409958
126SMAD3_21741376_ChIP-Seq_HESCs_Human0.98925082
127SMRT_27268052_Chip-Seq_Bcells_Human0.97526918
128* KDM2B_26808549_Chip-Seq_DND41_Human0.97312497
129* KDM2B_26808549_Chip-Seq_REH_Human0.97039429
130* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96179914
131TP53_16413492_ChIP-PET_HCT116_Human0.95826377
132STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.95813554
133* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95316875
134TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95308260
135EZH2_27294783_Chip-Seq_NPCs_Mouse0.94936748
136GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94812443
137P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94435321
138MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94400608
139ZNF274_21170338_ChIP-Seq_K562_Hela0.94175767
140* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94088266
141SPI1_23547873_ChIP-Seq_NB4_Human0.93637853
142SPI1_23127762_ChIP-Seq_K562_Human0.93546903
143ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93342386
144TCF4_23295773_ChIP-Seq_U87_Human0.92899924
145* SMAD4_21741376_ChIP-Seq_HESCs_Human0.92487607
146SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92275181
147RUNX2_22187159_ChIP-Seq_PCA_Human0.91514771
148BCAT_22108803_ChIP-Seq_LS180_Human0.91022321
149VDR_24763502_ChIP-Seq_THP-1_Human0.90908617
150FUS_26573619_Chip-Seq_HEK293_Human0.90374631
151GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90184789
152PIAS1_25552417_ChIP-Seq_VCAP_Human0.90178822
153* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89865837
154* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.89686826
155* TP53_18474530_ChIP-ChIP_U2OS_Human0.89592887
156* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.89540738
157PU_27001747_Chip-Seq_BMDM_Mouse0.89285759
158* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87964231
159HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.87191599
160* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.87054500
161GATA3_26560356_Chip-Seq_TH1_Human0.86258819
162OCT4_21477851_ChIP-Seq_ESCs_Mouse0.83515211
163MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.83351472

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.55973160
2MP0003880_abnormal_central_pattern5.19265964
3MP0002822_catalepsy4.87445943
4MP0003635_abnormal_synaptic_transmissio4.16744395
5MP0002063_abnormal_learning/memory/cond3.57981091
6MP0009745_abnormal_behavioral_response3.53757659
7MP0004270_analgesia3.23886266
8MP0001800_abnormal_humoral_immune3.15179481
9MP0002572_abnormal_emotion/affect_behav2.86201880
10MP0002064_seizures2.82043243
11MP0003436_decreased_susceptibility_to2.69305672
12MP0003724_increased_susceptibility_to2.65756786
13MP0005409_darkened_coat_color2.61792732
14MP0001835_abnormal_antigen_presentation2.59774300
15MP0005423_abnormal_somatic_nervous2.52501232
16MP0001968_abnormal_touch/_nociception2.49052350
17MP0001486_abnormal_startle_reflex2.47297640
18MP0009333_abnormal_splenocyte_physiolog2.42966006
19MP0005000_abnormal_immune_tolerance2.34014600
20MP0002272_abnormal_nervous_system2.32384068
21* MP0002420_abnormal_adaptive_immunity2.30804307
22* MP0002398_abnormal_bone_marrow2.27054183
23* MP0001819_abnormal_immune_cell2.26157016
24MP0002723_abnormal_immune_serum2.25505030
25MP0001501_abnormal_sleep_pattern2.22103867
26MP0005387_immune_system_phenotype2.11943333
27MP0001790_abnormal_immune_system2.11943333
28MP0003787_abnormal_imprinting2.08804092
29MP0005075_abnormal_melanosome_morpholog2.07091271
30MP0009046_muscle_twitch2.05859040
31MP0001873_stomach_inflammation2.05571300
32MP0000465_gastrointestinal_hemorrhage2.03275687
33MP0002405_respiratory_system_inflammati2.01084517
34* MP0000716_abnormal_immune_system1.99950114
35MP0000778_abnormal_nervous_system1.99876013
36MP0008877_abnormal_DNA_methylation1.99696124
37MP0008057_abnormal_DNA_replication1.99187954
38MP0002452_abnormal_antigen_presenting1.97869829
39MP0002184_abnormal_innervation1.96970215
40MP0002396_abnormal_hematopoietic_system1.95621654
41MP0008569_lethality_at_weaning1.91900136
42* MP0003763_abnormal_thymus_physiology1.91507208
43MP0002735_abnormal_chemical_nociception1.91194376
44* MP0002722_abnormal_immune_system1.88769665
45MP0000685_abnormal_immune_system1.88682225
46MP0002736_abnormal_nociception_after1.87691378
47MP0002557_abnormal_social/conspecific_i1.87361999
48MP0001984_abnormal_olfaction1.85923076
49* MP0000689_abnormal_spleen_morphology1.85691852
50MP0001529_abnormal_vocalization1.80191327
51MP0005025_abnormal_response_to1.79388144
52MP0001440_abnormal_grooming_behavior1.79152190
53MP0003300_gastrointestinal_ulcer1.78475723
54MP0002734_abnormal_mechanical_nocicepti1.76871081
55MP0004811_abnormal_neuron_physiology1.72958924
56MP0004947_skin_inflammation1.70098842
57MP0005499_abnormal_olfactory_system1.66380716
58MP0005394_taste/olfaction_phenotype1.66380716
59MP0002067_abnormal_sensory_capabilities1.61284550
60MP0004924_abnormal_behavior1.61157897
61MP0005386_behavior/neurological_phenoty1.61157897
62MP0001970_abnormal_pain_threshold1.60793017
63MP0001188_hyperpigmentation1.57238805
64MP0002733_abnormal_thermal_nociception1.54958297
65MP0002277_abnormal_respiratory_mucosa1.46138320
66MP0002419_abnormal_innate_immunity1.43516331
67* MP0002429_abnormal_blood_cell1.42406988
68MP0009785_altered_susceptibility_to1.41903162
69MP0010155_abnormal_intestine_physiology1.37315120
70MP0008995_early_reproductive_senescence1.35851147
71MP0006276_abnormal_autonomic_nervous1.35375071
72MP0004381_abnormal_hair_follicle1.34548229
73MP0002933_joint_inflammation1.34177446
74MP0002909_abnormal_adrenal_gland1.33478883
75MP0001851_eye_inflammation1.31876603
76MP0004130_abnormal_muscle_cell1.30172287
77MP0002882_abnormal_neuron_morphology1.30168599
78MP0004510_myositis1.28092329
79MP0003329_amyloid_beta_deposits1.26679008
80MP0005645_abnormal_hypothalamus_physiol1.26465358
81MP0003879_abnormal_hair_cell1.25174833
82MP0000955_abnormal_spinal_cord1.24934171
83MP0002066_abnormal_motor_capabilities/c1.19347338
84MP0008961_abnormal_basal_metabolism1.13776918
85MP0010234_abnormal_vibrissa_follicle1.12592554
86MP0002148_abnormal_hypersensitivity_rea1.12072623
87MP0009780_abnormal_chondrocyte_physiolo1.11193827
88MP0002152_abnormal_brain_morphology1.10031652
89MP0008789_abnormal_olfactory_epithelium1.09930304
90MP0008874_decreased_physiological_sensi1.09426658
91MP0001905_abnormal_dopamine_level1.06933007
92MP0005646_abnormal_pituitary_gland1.06674990
93MP0004883_abnormal_blood_vessel1.06072794
94* MP0000703_abnormal_thymus_morphology1.03777290
95MP0004742_abnormal_vestibular_system1.03025720
96MP0001845_abnormal_inflammatory_respons1.01150749
97MP0004858_abnormal_nervous_system1.00870940
98MP0004885_abnormal_endolymph0.99858484
99MP0006082_CNS_inflammation0.99178858
100MP0003221_abnormal_cardiomyocyte_apopto0.98697756
101MP0001502_abnormal_circadian_rhythm0.98520102
102MP0003121_genomic_imprinting0.94844701
103MP0003633_abnormal_nervous_system0.94304068
104* MP0002069_abnormal_eating/drinking_beha0.86579637
105MP0008872_abnormal_physiological_respon0.86160673
106MP0006292_abnormal_olfactory_placode0.83248533
107MP0005174_abnormal_tail_pigmentation0.80389519
108MP0000631_abnormal_neuroendocrine_gland0.79989405
109MP0000015_abnormal_ear_pigmentation0.78289165
110MP0002009_preneoplasia0.77268509
111MP0002751_abnormal_autonomic_nervous0.77243311
112MP0001663_abnormal_digestive_system0.76993522
113MP0001533_abnormal_skeleton_physiology0.76003938
114MP0001919_abnormal_reproductive_system0.75475576
115MP0001485_abnormal_pinna_reflex0.75238675
116MP0005671_abnormal_response_to0.73478590
117MP0003631_nervous_system_phenotype0.70617739
118MP0000569_abnormal_digit_pigmentation0.70425924
119MP0003861_abnormal_nervous_system0.70175894
120MP0003938_abnormal_ear_development0.68492601
121MP0003866_abnormal_defecation0.68245619
122MP0002234_abnormal_pharynx_morphology0.67217535
123MP0002166_altered_tumor_susceptibility0.67109441
124MP0002752_abnormal_somatic_nervous0.66737118
125MP0002006_tumorigenesis0.65658280
126MP0004085_abnormal_heartbeat0.64359125
127MP0001986_abnormal_taste_sensitivity0.63987401
128MP0008260_abnormal_autophagy0.63498571
129MP0002019_abnormal_tumor_incidence0.63481204
130MP0001963_abnormal_hearing_physiology0.61661700
131MP0004142_abnormal_muscle_tone0.61376079
132MP0005535_abnormal_body_temperature0.61330098
133MP0009765_abnormal_xenobiotic_induced0.60481130
134MP0001177_atelectasis0.59436626
135MP0004185_abnormal_adipocyte_glucose0.58692036
136MP0010769_abnormal_survival0.57659733
137MP0002102_abnormal_ear_morphology0.56942953
138MP0003303_peritoneal_inflammation0.56325336
139MP0000490_abnormal_crypts_of0.56300679
140MP0000013_abnormal_adipose_tissue0.55422236
141MP0005187_abnormal_penis_morphology0.55417284
142MP0000026_abnormal_inner_ear0.55030245
143MP0010768_mortality/aging0.54912005
144MP0008873_increased_physiological_sensi0.52895655
145MP0002082_postnatal_lethality0.51304653
146MP0010770_preweaning_lethality0.51304653
147MP0000920_abnormal_myelination0.51131547
148MP0004484_altered_response_of0.49981188
149MP0001348_abnormal_lacrimal_gland0.49941337
150MP0002928_abnormal_bile_duct0.49857828
151MP0008770_decreased_survivor_rate0.49249080
152MP0004808_abnormal_hematopoietic_stem0.49212959
153MP0002998_abnormal_bone_remodeling0.49187032
154MP0002229_neurodegeneration0.48171372
155MP0000427_abnormal_hair_cycle0.48149932
156MP0003075_altered_response_to0.47536292
157MP0005310_abnormal_salivary_gland0.47336627
158MP0002083_premature_death0.46836654
159MP0001664_abnormal_digestion0.46802376
160MP0001943_abnormal_respiration0.46489186
161MP0002098_abnormal_vibrissa_morphology0.45783545
162MP0003448_altered_tumor_morphology0.45325076
163MP0005464_abnormal_platelet_physiology0.44508912

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.06560982
2Myokymia (HP:0002411)5.74120344
3Focal seizures (HP:0007359)5.11243424
4Eczematoid dermatitis (HP:0000976)4.28899425
5Visual hallucinations (HP:0002367)4.05323839
6T lymphocytopenia (HP:0005403)3.96251307
7Atonic seizures (HP:0010819)3.86729225
8Febrile seizures (HP:0002373)3.85863726
9Elevated erythrocyte sedimentation rate (HP:0003565)3.85399540
10Absence seizures (HP:0002121)3.72629049
11Epileptic encephalopathy (HP:0200134)3.72267218
12Abnormality of T cell number (HP:0011839)3.69914154
13Broad-based gait (HP:0002136)3.67068601
14Abnormality of T cells (HP:0002843)3.60879130
15Recurrent fungal infections (HP:0002841)3.59937755
16Abnormal delayed hypersensitivity skin test (HP:0002963)3.58461713
17Progressive cerebellar ataxia (HP:0002073)3.43395425
18Dialeptic seizures (HP:0011146)3.43138978
19Pustule (HP:0200039)3.38627300
20IgG deficiency (HP:0004315)3.37312759
21Hyperventilation (HP:0002883)3.29080597
22Amblyopia (HP:0000646)3.19609228
23Stereotypic behavior (HP:0000733)3.07858831
24Recurrent bacterial skin infections (HP:0005406)2.99564678
25Abnormality of eosinophils (HP:0001879)2.99524810
26Autoimmune hemolytic anemia (HP:0001890)2.93915526
27Myositis (HP:0100614)2.92191993
28Excessive salivation (HP:0003781)2.90462264
29Drooling (HP:0002307)2.90462264
30Stomach cancer (HP:0012126)2.84872556
31Generalized tonic-clonic seizures (HP:0002069)2.84458608
32Annular pancreas (HP:0001734)2.84423035
33Impaired vibration sensation in the lower limbs (HP:0002166)2.83950076
34Abnormality of B cell number (HP:0010975)2.82659307
35B lymphocytopenia (HP:0010976)2.82659307
36Truncal ataxia (HP:0002078)2.82002739
37Chronic mucocutaneous candidiasis (HP:0002728)2.79264138
38Recurrent cutaneous fungal infections (HP:0011370)2.79264138
39Severe combined immunodeficiency (HP:0004430)2.78358229
40Abnormality of the columella (HP:0009929)2.78160884
41Retrobulbar optic neuritis (HP:0100654)2.77753468
42Optic neuritis (HP:0100653)2.77753468
43Panhypogammaglobulinemia (HP:0003139)2.77671332
44Leukocytosis (HP:0001974)2.77325208
45Encephalitis (HP:0002383)2.75840539
46Poor eye contact (HP:0000817)2.73501301
47Basal cell carcinoma (HP:0002671)2.73379941
48Recurrent viral infections (HP:0004429)2.72246538
49Supranuclear gaze palsy (HP:0000605)2.68346796
50Abnormality of binocular vision (HP:0011514)2.61642520
51Diplopia (HP:0000651)2.61642520
52Impaired social interactions (HP:0000735)2.60651201
53Abnormal social behavior (HP:0012433)2.60651201
54Abnormality of oral frenula (HP:0000190)2.58707475
55Gastrointestinal infarctions (HP:0005244)2.58299427
56Increased IgE level (HP:0003212)2.57067889
57Fair hair (HP:0002286)2.54451053
58Spontaneous hematomas (HP:0007420)2.54387649
59Lymphopenia (HP:0001888)2.53260530
60Amyotrophic lateral sclerosis (HP:0007354)2.53094684
61Gaze-evoked nystagmus (HP:0000640)2.52620962
62Ankyloglossia (HP:0010296)2.51804364
63Hypochromic microcytic anemia (HP:0004840)2.51218799
64Urinary urgency (HP:0000012)2.51047196
65Dysmetria (HP:0001310)2.50603598
66Depression (HP:0000716)2.49687398
67Anxiety (HP:0000739)2.48988804
68Recurrent abscess formation (HP:0002722)2.48098368
69Pointed chin (HP:0000307)2.47749240
70Genetic anticipation (HP:0003743)2.46078944
71Action tremor (HP:0002345)2.45050777
72Abnormality of the fingertips (HP:0001211)2.44722623
73Granulocytopenia (HP:0001913)2.43628315
74Recurrent bronchitis (HP:0002837)2.40256180
75Cerebral inclusion bodies (HP:0100314)2.40070620
76Urinary bladder sphincter dysfunction (HP:0002839)2.37207887
77Impaired smooth pursuit (HP:0007772)2.36474836
78Insidious onset (HP:0003587)2.34291017
79Termporal pattern (HP:0011008)2.34291017
80Verrucae (HP:0200043)2.33972215
81Papilloma (HP:0012740)2.33972215
82Orchitis (HP:0100796)2.33870119
83Meningitis (HP:0001287)2.33416548
84Thyroiditis (HP:0100646)2.32701118
85Ankle clonus (HP:0011448)2.31187801
86Abnormality of cells of the lymphoid lineage (HP:0012140)2.31108938
87Dysdiadochokinesis (HP:0002075)2.30957333
88Recurrent skin infections (HP:0001581)2.29497535
89Megalencephaly (HP:0001355)2.26870707
90Limb dystonia (HP:0002451)2.26657262
91Increased IgM level (HP:0003496)2.26628238
92Deep palmar crease (HP:0006191)2.26538855
93Obstructive sleep apnea (HP:0002870)2.24337410
94Progressive inability to walk (HP:0002505)2.24018782
95Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.23919999
96Short 4th metacarpal (HP:0010044)2.23919999
97Combined immunodeficiency (HP:0005387)2.21717359
98Absent speech (HP:0001344)2.21400500
99Keratoconjunctivitis sicca (HP:0001097)2.20269457
100IgM deficiency (HP:0002850)2.19099652
101Dysmetric saccades (HP:0000641)2.18860639
102Vasculitis (HP:0002633)2.16953729
103Chest pain (HP:0100749)2.15881500
104Generalized hypopigmentation of hair (HP:0011358)2.15497621
105Inappropriate behavior (HP:0000719)2.15033525
106Hypochromic anemia (HP:0001931)2.13354020
107Keratoconjunctivitis (HP:0001096)2.12528754
108Lower limb amyotrophy (HP:0007210)2.07942041
109Mutism (HP:0002300)2.06549768
110Palpebral edema (HP:0100540)2.06234713
111Deeply set eye (HP:0000490)2.06084750
112Truncus arteriosus (HP:0001660)2.05668683
113Abnormality of T cell physiology (HP:0011840)2.03506466
114Lower limb asymmetry (HP:0100559)2.03361260
115Autism (HP:0000717)2.02929965
116Abnormality of salivation (HP:0100755)2.02632715
117Focal dystonia (HP:0004373)2.02501615
118Abnormality of the lower motor neuron (HP:0002366)2.02381565
119Torticollis (HP:0000473)2.02081594
120Epileptiform EEG discharges (HP:0011182)2.00368418
121Abnormal eating behavior (HP:0100738)1.99153057
122Scanning speech (HP:0002168)1.97965314
123Prominent nose (HP:0000448)1.97858855
124Hemoptysis (HP:0002105)1.97818658
125Mediastinal lymphadenopathy (HP:0100721)1.97506469
126Subacute progressive viral hepatitis (HP:0006572)1.96179948
127Thickened helices (HP:0000391)1.95479968
128Volvulus (HP:0002580)1.94072366
129Exotropia (HP:0000577)1.93020615
130Slow saccadic eye movements (HP:0000514)1.90997662
131Neurofibrillary tangles (HP:0002185)1.88481650
132Sporadic (HP:0003745)1.88395230
133Abnormal hair whorl (HP:0010721)1.87656694
134Apathy (HP:0000741)1.86888141
135Abnormality of ocular smooth pursuit (HP:0000617)1.86471120
136Eosinophilia (HP:0001880)1.85845249
137Pulmonary infiltrates (HP:0002113)1.84832119
138Spastic gait (HP:0002064)1.84716110
139Hypoplasia of the thymus (HP:0000778)1.84082844
140Hemiparesis (HP:0001269)1.83892066
141Impaired vibratory sensation (HP:0002495)1.83088555
142Chronic diarrhea (HP:0002028)1.82941579
143Protruding tongue (HP:0010808)1.81693982
144Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.81534790
145Curly hair (HP:0002212)1.81521468
146Neoplasm of the tracheobronchial system (HP:0100552)1.81368252
147Prolonged bleeding time (HP:0003010)1.81060568
148Inability to walk (HP:0002540)1.78895430
149Hypoproteinemia (HP:0003075)1.78821792
150Lymphoma (HP:0002665)1.78662810
151Long clavicles (HP:0000890)1.77086327
152EEG with generalized epileptiform discharges (HP:0011198)1.76781084
153Gingivitis (HP:0000230)1.76379576
154Tented upper lip vermilion (HP:0010804)1.75201374
155IgA deficiency (HP:0002720)1.74494060
156Autoimmune thrombocytopenia (HP:0001973)1.74465249
157Heterotopia (HP:0002282)1.74419325
158Widely spaced teeth (HP:0000687)1.74342953
159Cutis marmorata (HP:0000965)1.74114537
160Abnormality of the labia minora (HP:0012880)1.73226961
161Inflammation of the large intestine (HP:0002037)1.72214758
162Obsessive-compulsive behavior (HP:0000722)1.72056170
163Distal lower limb amyotrophy (HP:0008944)1.71069572
164Gastroesophageal reflux (HP:0002020)1.69991964
165Papilledema (HP:0001085)1.69627115
166Aqueductal stenosis (HP:0002410)1.69083680
167Bowel incontinence (HP:0002607)1.67743414
168Insomnia (HP:0100785)1.64899390
169Hypsarrhythmia (HP:0002521)1.63199901
170Diminished motivation (HP:0000745)1.62067240
171Stomatitis (HP:0010280)1.61810913

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA46.16528159
2NTRK34.14525791
3RIPK43.24997161
4MARK12.87426535
5SIK22.78375807
6TXK2.55954540
7MAP3K92.38302551
8NTRK22.29645932
9MAP3K102.24886959
10FRK2.13083787
11MAP3K42.12700440
12MINK12.06139773
13TAOK31.97358348
14KSR11.93100233
15WNK31.84266800
16FES1.80275813
17TYRO31.76556459
18BTK1.76025668
19DAPK21.75520936
20PRPF4B1.75032015
21MAP3K131.74676251
22BMPR21.69682341
23MAP2K71.68172223
24KSR21.66647570
25GRK61.51873471
26MARK31.49237906
27DAPK11.47844593
28TYK21.47827902
29CDK51.44384512
30TEC1.40594230
31CAMKK11.38409847
32TNIK1.37533513
33CASK1.37412157
34MAPK131.28600675
35PNCK1.26492156
36PAK61.24349434
37MARK21.22960860
38CSK1.22552008
39PLK21.20226945
40YES11.18378386
41JAK11.17659408
42MAP4K11.16034813
43CAMK2B1.13363777
44MAP3K71.12152071
45RAF11.11725329
46BRD41.11555872
47CDK121.11194750
48IRAK41.07872395
49PRKD31.07300966
50STK111.06739387
51PRKCH1.05500408
52PRKCQ1.02162778
53TAOK11.01386255
54JAK31.01057244
55LYN0.99966028
56MAP3K120.99296445
57MAP3K20.96453693
58TNK20.95626770
59MAP2K40.92873289
60PRKCG0.92545475
61FGFR20.92054669
62CAMK2A0.90580182
63MAP3K140.89702176
64PASK0.88966286
65NME10.88105865
66BLK0.87205100
67TRIM280.86400102
68ITK0.86066748
69PRKD20.85009498
70DYRK1A0.84395180
71PIM10.84290009
72SYK0.83328916
73IRAK10.82594306
74UHMK10.82442214
75PTK2B0.78405165
76FGR0.77914530
77STK380.77602266
78HCK0.76733349
79SGK20.75383235
80NTRK10.74934033
81ARAF0.74752238
82SGK10.73040218
83GRK50.72038390
84DMPK0.70816343
85JAK20.70043423
86FYN0.69126632
87CAMKK20.68740025
88FGFR30.66541031
89CAMK10.65770576
90SGK30.64455863
91CSNK1G20.62830594
92SGK2230.62608073
93SGK4940.62608073
94RET0.62207810
95IKBKB0.60867538
96BCR0.59690930
97DYRK1B0.58664931
98PDK10.58547539
99CDK180.57950036
100CDK190.56013972
101CDK150.55190969
102CDK60.55092723
103PDGFRB0.54724486
104CDK140.54173027
105CDK40.54154745
106SIK30.52559279
107CAMK40.52407797
108MKNK20.50580878
109ERBB30.50250395
110CDK11A0.49143408
111AKT30.48695159
112MAPK100.46600048
113EPHB10.46409326
114MAPK120.45899182
115ALK0.45189438
116WNK10.45165800
117NLK0.44871981
118EEF2K0.44331043
119MAP3K60.44200672
120LCK0.44067230
121STK40.43918549
122PRKCZ0.43456146
123MAP3K10.42285561
124IRAK20.39581877
125NEK60.38781602
126ACVR1B0.38279886
127PRKCB0.38183705
128MAPK70.38058025
129EPHA30.37484411
130CLK10.37480186
131PAK30.36890946
132HIPK20.35369630
133RPS6KA30.35228111
134MAPK90.34208504
135MAPK80.33225858
136ZAP700.32571077
137IKBKE0.32413773
138FGFR40.31562823

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.18446928
2Long-term potentiation_Homo sapiens_hsa047202.86910324
3Olfactory transduction_Homo sapiens_hsa047402.80820951
4Amphetamine addiction_Homo sapiens_hsa050312.44351507
5Circadian entrainment_Homo sapiens_hsa047132.39822907
6Glutamatergic synapse_Homo sapiens_hsa047242.36157909
7Morphine addiction_Homo sapiens_hsa050322.36018500
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.34935593
9Dopaminergic synapse_Homo sapiens_hsa047282.13107911
10GABAergic synapse_Homo sapiens_hsa047272.07960610
11Salivary secretion_Homo sapiens_hsa049701.98780786
12Measles_Homo sapiens_hsa051621.94426697
13T cell receptor signaling pathway_Homo sapiens_hsa046601.88883529
14Renin secretion_Homo sapiens_hsa049241.87947549
15Cholinergic synapse_Homo sapiens_hsa047251.81739500
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.71322541
17Synaptic vesicle cycle_Homo sapiens_hsa047211.69706185
18Cocaine addiction_Homo sapiens_hsa050301.69679399
19Gastric acid secretion_Homo sapiens_hsa049711.68085800
20Oxytocin signaling pathway_Homo sapiens_hsa049211.66913821
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.63203411
22Primary immunodeficiency_Homo sapiens_hsa053401.59376902
23Taste transduction_Homo sapiens_hsa047421.58686471
24Calcium signaling pathway_Homo sapiens_hsa040201.57603575
25Long-term depression_Homo sapiens_hsa047301.56063531
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.53223335
27Serotonergic synapse_Homo sapiens_hsa047261.50332813
28Hematopoietic cell lineage_Homo sapiens_hsa046401.50252556
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.50207495
30Graft-versus-host disease_Homo sapiens_hsa053321.45034384
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42081630
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.40206533
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.40150328
34Allograft rejection_Homo sapiens_hsa053301.39234878
35Insulin secretion_Homo sapiens_hsa049111.38941109
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.38845810
37GnRH signaling pathway_Homo sapiens_hsa049121.38724107
38Axon guidance_Homo sapiens_hsa043601.37410708
39Autoimmune thyroid disease_Homo sapiens_hsa053201.36812642
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33607022
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.31906238
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.29915845
43cAMP signaling pathway_Homo sapiens_hsa040241.28682284
44Gap junction_Homo sapiens_hsa045401.27962181
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23391548
46Hepatitis B_Homo sapiens_hsa051611.21223370
47Melanogenesis_Homo sapiens_hsa049161.19807607
48Glioma_Homo sapiens_hsa052141.14451308
49ErbB signaling pathway_Homo sapiens_hsa040121.13652901
50Estrogen signaling pathway_Homo sapiens_hsa049151.11143047
51cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10579909
52VEGF signaling pathway_Homo sapiens_hsa043701.06396817
53TNF signaling pathway_Homo sapiens_hsa046681.03067060
54Leishmaniasis_Homo sapiens_hsa051400.98073060
55Toll-like receptor signaling pathway_Homo sapiens_hsa046200.97777693
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97089025
57Choline metabolism in cancer_Homo sapiens_hsa052310.96925772
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96502064
59Phototransduction_Homo sapiens_hsa047440.95695332
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94759709
61Prostate cancer_Homo sapiens_hsa052150.94585416
62Herpes simplex infection_Homo sapiens_hsa051680.94302774
63Dorso-ventral axis formation_Homo sapiens_hsa043200.94274965
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.93159856
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92023460
66Non-small cell lung cancer_Homo sapiens_hsa052230.91070211
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.88729715
68Colorectal cancer_Homo sapiens_hsa052100.87109652
69Endometrial cancer_Homo sapiens_hsa052130.86596669
70Tuberculosis_Homo sapiens_hsa051520.86033610
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.85468463
72Toxoplasmosis_Homo sapiens_hsa051450.85466437
73MAPK signaling pathway_Homo sapiens_hsa040100.85297135
74Type II diabetes mellitus_Homo sapiens_hsa049300.85055130
75Rap1 signaling pathway_Homo sapiens_hsa040150.83257494
76Chemokine signaling pathway_Homo sapiens_hsa040620.81316637
77Influenza A_Homo sapiens_hsa051640.79209466
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79165966
79Viral carcinogenesis_Homo sapiens_hsa052030.78540468
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.78201265
81Oocyte meiosis_Homo sapiens_hsa041140.75482426
82Wnt signaling pathway_Homo sapiens_hsa043100.75253789
83Antigen processing and presentation_Homo sapiens_hsa046120.73974284
84Pancreatic secretion_Homo sapiens_hsa049720.72990855
85Ras signaling pathway_Homo sapiens_hsa040140.72955565
86Viral myocarditis_Homo sapiens_hsa054160.72598943
87Epstein-Barr virus infection_Homo sapiens_hsa051690.71620261
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71562108
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71497252
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71337435
91Hepatitis C_Homo sapiens_hsa051600.70767898
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70403249
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70180034
94HTLV-I infection_Homo sapiens_hsa051660.70010471
95Type I diabetes mellitus_Homo sapiens_hsa049400.67512166
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64444542
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.63991540
98Notch signaling pathway_Homo sapiens_hsa043300.63889266
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.63771874
100Alcoholism_Homo sapiens_hsa050340.63734171
101B cell receptor signaling pathway_Homo sapiens_hsa046620.62600882
102Renal cell carcinoma_Homo sapiens_hsa052110.61943354
103Circadian rhythm_Homo sapiens_hsa047100.60525461
104Collecting duct acid secretion_Homo sapiens_hsa049660.58714386
105Apoptosis_Homo sapiens_hsa042100.57829111
106MicroRNAs in cancer_Homo sapiens_hsa052060.56623277
107mTOR signaling pathway_Homo sapiens_hsa041500.56606725
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55936698
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55640381
110Osteoclast differentiation_Homo sapiens_hsa043800.55627216
111Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55155495
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53894785
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53587859
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53306107
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52129654
116Platelet activation_Homo sapiens_hsa046110.52037940
117Regulation of autophagy_Homo sapiens_hsa041400.51561618
118Linoleic acid metabolism_Homo sapiens_hsa005910.51170368
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50771153
120Inositol phosphate metabolism_Homo sapiens_hsa005620.50664390
121Malaria_Homo sapiens_hsa051440.50577626
122Thyroid hormone synthesis_Homo sapiens_hsa049180.50410486
123African trypanosomiasis_Homo sapiens_hsa051430.50211558
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49731665
125Acute myeloid leukemia_Homo sapiens_hsa052210.49124259
126Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47877045
127Prolactin signaling pathway_Homo sapiens_hsa049170.47302428
128Chronic myeloid leukemia_Homo sapiens_hsa052200.47032920
129Glucagon signaling pathway_Homo sapiens_hsa049220.46740845
130Endocytosis_Homo sapiens_hsa041440.46277902
131Dilated cardiomyopathy_Homo sapiens_hsa054140.46077522
132Cardiac muscle contraction_Homo sapiens_hsa042600.45391299
133Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44330916
134FoxO signaling pathway_Homo sapiens_hsa040680.42565161
135Thyroid cancer_Homo sapiens_hsa052160.42125480
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42078392
137Pancreatic cancer_Homo sapiens_hsa052120.41330316
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38523298
139AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37860344

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »