BCL2L10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female gonad development (GO:2000194)9.21205283
2piRNA metabolic process (GO:0034587)7.47652069
3regulation of meiosis (GO:0040020)7.32812492
4meiotic cell cycle (GO:0051321)6.86322764
5retinal cone cell development (GO:0046549)6.85740528
6attachment of spindle microtubules to kinetochore (GO:0008608)6.85239639
7regulation of DNA methylation (GO:0044030)6.71363263
8mitotic metaphase plate congression (GO:0007080)6.48330114
9oocyte development (GO:0048599)6.44957200
10mitotic chromosome condensation (GO:0007076)6.42447377
11negative regulation of meiosis (GO:0045835)6.42367866
12negative regulation of meiotic cell cycle (GO:0051447)6.40616079
13glycine transport (GO:0015816)6.31778252
14positive regulation of histone H3-K4 methylation (GO:0051571)6.23532617
15regulation of cell maturation (GO:1903429)6.19679708
16regulation of histone H3-K9 methylation (GO:0051570)6.16430118
17histone H2A monoubiquitination (GO:0035518)5.81774240
18regulation of meiotic cell cycle (GO:0051445)5.78802477
19multicellular organism reproduction (GO:0032504)5.52015270
20* female gamete generation (GO:0007292)5.47134790
21metaphase plate congression (GO:0051310)5.44282560
22regulation of histone H3-K27 methylation (GO:0061085)5.37347272
23synapsis (GO:0007129)5.32617638
24histone H2A ubiquitination (GO:0033522)5.11688738
25positive regulation of gastrulation (GO:2000543)5.04515887
26maturation of 5.8S rRNA (GO:0000460)5.01314302
27establishment of chromosome localization (GO:0051303)4.98444357
28protein K6-linked ubiquitination (GO:0085020)4.98055246
29centriole replication (GO:0007099)4.91587780
30oocyte maturation (GO:0001556)4.83940757
31DNA damage induced protein phosphorylation (GO:0006975)4.82713400
32regulation of exit from mitosis (GO:0007096)4.78555540
33male meiosis (GO:0007140)4.71743178
34regulation of sister chromatid cohesion (GO:0007063)4.66157845
35protein localization to kinetochore (GO:0034501)4.62239059
36L-amino acid import (GO:0043092)4.58890317
37regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.56794723
38DNA methylation involved in gamete generation (GO:0043046)4.51917847
39meiotic chromosome segregation (GO:0045132)4.50699146
40oogenesis (GO:0048477)4.50475816
41negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.50301725
42primitive streak formation (GO:0090009)4.46910505
43mitotic sister chromatid segregation (GO:0000070)4.41472667
44translesion synthesis (GO:0019985)4.32089667
45protein localization to chromosome, centromeric region (GO:0071459)4.29928530
46positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.26494305
47negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)4.25360038
48chromosome organization involved in meiosis (GO:0070192)4.24804980
49negative regulation of DNA-templated transcription, elongation (GO:0032785)4.22898610
50negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.22898610
51synaptonemal complex assembly (GO:0007130)4.22741935
52protein kinase C signaling (GO:0070528)4.22595681
53labyrinthine layer development (GO:0060711)4.21528140
54base-excision repair, AP site formation (GO:0006285)4.21322077
55negative regulation of smooth muscle cell differentiation (GO:0051151)4.20489016
56CENP-A containing nucleosome assembly (GO:0034080)4.19531097
57chromatin remodeling at centromere (GO:0031055)4.06295300
58protein localization to chromosome (GO:0034502)4.03898194
59regulation of mitotic spindle organization (GO:0060236)4.00989091
60regulation of meiosis I (GO:0060631)3.99404628
61regulation of steroid hormone secretion (GO:2000831)3.99205538
62chromosome segregation (GO:0007059)3.98121368
63glycerophospholipid catabolic process (GO:0046475)3.96160714
64regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.93578813
65nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.91632541
66positive regulation of humoral immune response (GO:0002922)3.90138288
67establishment of spindle localization (GO:0051293)3.88097052
68regulation of spindle organization (GO:0090224)3.86826430
69positive regulation of histone methylation (GO:0031062)3.85249438
70negative regulation of execution phase of apoptosis (GO:1900118)3.85008514
71positive regulation of chromosome segregation (GO:0051984)3.84295041
72notochord development (GO:0030903)3.84172115
73chaperone-mediated protein transport (GO:0072321)3.82946728
74DNA replication-independent nucleosome organization (GO:0034724)3.82824305
75DNA replication-independent nucleosome assembly (GO:0006336)3.82824305
76pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.81746188
77male meiosis I (GO:0007141)3.81037207
78regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.79973751
79histone exchange (GO:0043486)3.77907892
80positive regulation of megakaryocyte differentiation (GO:0045654)3.77380827
81chromatin assembly or disassembly (GO:0006333)3.76605542
82regulation of spindle checkpoint (GO:0090231)3.73539105
83regulation of transforming growth factor beta2 production (GO:0032909)3.71787890
84DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.71578500
85regulation of RIG-I signaling pathway (GO:0039535)3.70921222
86synaptonemal complex organization (GO:0070193)3.70626704
87relaxation of smooth muscle (GO:0044557)3.66909200
88DNA damage response, signal transduction resulting in transcription (GO:0042772)3.66632267
89microtubule severing (GO:0051013)3.63378130
90regulation of histone H3-K4 methylation (GO:0051569)3.62421459
91reproduction (GO:0000003)3.59527586
92meiotic nuclear division (GO:0007126)3.59079165
93regulation of retinoic acid receptor signaling pathway (GO:0048385)3.56284489
94gene silencing by RNA (GO:0031047)3.55704551
95spindle checkpoint (GO:0031577)3.54517461
96regulation of steroid hormone biosynthetic process (GO:0090030)3.54431755
97sister chromatid segregation (GO:0000819)3.54294050
98positive regulation of Cdc42 GTPase activity (GO:0043089)3.54275381
99positive regulation of reproductive process (GO:2000243)3.50626371
100phosphorelay signal transduction system (GO:0000160)3.50600330
101positive regulation of mitotic sister chromatid separation (GO:1901970)3.48429308
102positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.48429308
103positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.48429308
104positive regulation of uterine smooth muscle contraction (GO:0070474)3.48169507
105microtubule nucleation (GO:0007020)3.48017437
106gene silencing (GO:0016458)3.46586224
107mitotic nuclear envelope disassembly (GO:0007077)3.45277654
108negative regulation of hormone metabolic process (GO:0032351)3.43808835
109negative regulation of hormone biosynthetic process (GO:0032353)3.43808835
110DNA replication-dependent nucleosome organization (GO:0034723)3.43363997
111DNA replication-dependent nucleosome assembly (GO:0006335)3.43363997
112kinetochore assembly (GO:0051382)3.42888426
113regulation of histone methylation (GO:0031060)3.41130320
114somite rostral/caudal axis specification (GO:0032525)3.40859870
115neuron fate determination (GO:0048664)3.36175245
116establishment of spindle orientation (GO:0051294)3.35418098
117centriole assembly (GO:0098534)3.34651384
118regulation of chromosome segregation (GO:0051983)3.34165924
119fertilization (GO:0009566)3.33882445
120DNA alkylation (GO:0006305)3.33305709
121DNA methylation (GO:0006306)3.33305709
122negative regulation of cell division (GO:0051782)3.33084203
123type B pancreatic cell development (GO:0003323)3.29336823
124female gonad development (GO:0008585)3.28997036
125negative regulation of nuclear division (GO:0051784)3.28774178
126nuclear envelope disassembly (GO:0051081)3.28627697
127membrane disassembly (GO:0030397)3.28627697
128regulation of double-strand break repair via homologous recombination (GO:0010569)3.28308940
129kinetochore organization (GO:0051383)3.28042002
130negative regulation of cAMP-mediated signaling (GO:0043951)3.27702178
131phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.25403413
132paraxial mesoderm development (GO:0048339)3.20804399
133nucleus organization (GO:0006997)3.19811221
134nucleotide-excision repair, DNA gap filling (GO:0006297)3.19678412
135mitotic spindle checkpoint (GO:0071174)3.17952651
136dopamine biosynthetic process (GO:0042416)3.16571463
137negative regulation of reproductive process (GO:2000242)3.16104130
138negative regulation of histone methylation (GO:0031061)3.15595666
139DNA replication checkpoint (GO:0000076)3.13082319
140pyrimidine-containing compound transmembrane transport (GO:0072531)3.11364376
141amino acid import (GO:0043090)3.10627997
142snRNA transcription (GO:0009301)3.09854454
143meiotic cell cycle process (GO:1903046)3.09847813
144meiosis I (GO:0007127)3.09690440
145regulation of acrosome reaction (GO:0060046)3.09381973
146cytoplasmic mRNA processing body assembly (GO:0033962)3.07974468
147folic acid-containing compound biosynthetic process (GO:0009396)3.07783983
148regulation of reproductive process (GO:2000241)3.07575742
149positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.07398982
150pyrimidine nucleotide catabolic process (GO:0006244)3.07094909
151ventricular cardiac muscle cell development (GO:0055015)3.06674034
152regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.06488961
153postreplication repair (GO:0006301)3.05105453
154sister chromatid cohesion (GO:0007062)3.01832853
155protein monoubiquitination (GO:0006513)2.99468148
156regulation of corticosteroid hormone secretion (GO:2000846)2.96137029
157regulation of chromatin silencing (GO:0031935)2.95591464
158regulation of cytokine production involved in inflammatory response (GO:1900015)2.94395265

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.34035888
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.38097354
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.98624118
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.90562050
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.36263126
6SMAD_19615063_ChIP-ChIP_OVARY_Human3.67868176
7AR_21909140_ChIP-Seq_LNCAP_Human3.65124409
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.65038816
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.65038816
10KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.65038816
11SALL1_21062744_ChIP-ChIP_HESCs_Human3.60319246
12E2F7_22180533_ChIP-Seq_HELA_Human3.46922373
13KAP1_22055183_ChIP-Seq_ESCs_Mouse3.30105080
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.17909059
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.87618588
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.52249343
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.48569451
18NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.47816838
19GATA1_26923725_Chip-Seq_HPCs_Mouse2.47602896
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.30835459
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.18091203
22RUNX1_26923725_Chip-Seq_HPCs_Mouse2.09032249
23BP1_19119308_ChIP-ChIP_Hs578T_Human2.08812434
24MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse2.01136254
25NOTCH1_21737748_ChIP-Seq_TLL_Human2.00549660
26EZH2_22144423_ChIP-Seq_EOC_Human13.2841297
27GBX2_23144817_ChIP-Seq_PC3_Human1.97354641
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.97311533
29MYC_18940864_ChIP-ChIP_HL60_Human1.91042193
30LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64257078
31CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63997300
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59264174
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.59169172
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.58304330
35IRF1_19129219_ChIP-ChIP_H3396_Human1.53486746
36TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.50992379
37FOXM1_26456572_ChIP-Seq_MCF-7_Human1.49650434
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49291178
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.42891246
40FUS_26573619_Chip-Seq_HEK293_Human1.42640607
41ESR1_15608294_ChIP-ChIP_MCF-7_Human1.37416546
42CBP_20019798_ChIP-Seq_JUKART_Human1.35701204
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35701204
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34942256
45ELK4_26923725_Chip-Seq_MESODERM_Mouse1.34832791
46RNF2_27304074_Chip-Seq_NSC_Mouse1.34222941
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32601428
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28535613
49CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.27751128
50CDX2_22108803_ChIP-Seq_LS180_Human1.26851304
51SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.26781476
52PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.26583522
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25586082
54HTT_18923047_ChIP-ChIP_STHdh_Human1.25555892
55STAT3_23295773_ChIP-Seq_U87_Human1.25118674
56MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.24847927
57SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.23733915
58CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.23084201
59TP63_19390658_ChIP-ChIP_HaCaT_Human1.21498498
60TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.21211211
61KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.21101912
62STAT1_17558387_ChIP-Seq_HELA_Human1.18507948
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18458761
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18120048
65EWS_26573619_Chip-Seq_HEK293_Human1.17426292
66FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.17017510
67AUTS2_25519132_ChIP-Seq_293T-REX_Human1.16559942
68NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.15132328
69TCF4_23295773_ChIP-Seq_U87_Human1.14788155
70NANOG_21062744_ChIP-ChIP_HESCs_Human1.14538800
71HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14524388
72* PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14389829
73GF1B_26923725_Chip-Seq_HPCs_Mouse1.13607611
74IGF1R_20145208_ChIP-Seq_DFB_Human1.13395758
75PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12245233
76CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.11234031
77GATA3_21867929_ChIP-Seq_TH1_Mouse1.10411334
78ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.10090556
79NFYA_21822215_ChIP-Seq_K562_Human1.09628601
80KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.07646955
81ERG_20517297_ChIP-Seq_VCAP_Human1.06813245
82ESR1_20079471_ChIP-ChIP_T-47D_Human1.06230634
83CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05135810
84ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04897423
85* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04201100
86VDR_22108803_ChIP-Seq_LS180_Human1.01211026
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00964660
88AR_25329375_ChIP-Seq_VCAP_Human1.00871674
89EP300_21415370_ChIP-Seq_HL-1_Mouse1.00284109
90SMRT_27268052_Chip-Seq_Bcells_Human0.99763239
91CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99256342
92PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.99212844
93NANOG_18555785_Chip-Seq_ESCs_Mouse0.98654010
94RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98303706
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95561923
96MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.95091854
97FOXH1_21741376_ChIP-Seq_EPCs_Human0.94779791
98TAL1_26923725_Chip-Seq_HPCs_Mouse0.94573746
99* NANOG_20526341_ChIP-Seq_ESCs_Human0.94375110
100EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93982534
101CBP_21632823_ChIP-Seq_H3396_Human0.93618438
102ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93216765
103SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92176534
104CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92067979
105LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91271459
106SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.91112005
107CREB1_15753290_ChIP-ChIP_HEK293T_Human0.90836168
108RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90794755
109RUNX2_22187159_ChIP-Seq_PCA_Human0.90770963
110TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.90751751
111SALL4_22934838_ChIP-ChIP_CD34+_Human0.90402458
112KDM2B_26808549_Chip-Seq_REH_Human0.90110239
113FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.89546704
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88980092
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88980092
116SMAD4_21741376_ChIP-Seq_EPCs_Human0.88008621
117PRDM14_20953172_ChIP-Seq_ESCs_Human0.87398310
118GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86926430
119TBX5_21415370_ChIP-Seq_HL-1_Mouse0.86415958
120AHR_22903824_ChIP-Seq_MCF-7_Human0.86107741
121NFE2_27457419_Chip-Seq_LIVER_Mouse0.85661808
122SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84358984
123SMAD4_21799915_ChIP-Seq_A2780_Human0.84347931
124OCT1_27270436_Chip-Seq_PROSTATE_Human0.84214938
125CTCF_18555785_Chip-Seq_ESCs_Mouse0.84201000
126TBL1_22424771_ChIP-Seq_293T_Human0.84102362
127P300_19829295_ChIP-Seq_ESCs_Human0.84101525
128GF1_26923725_Chip-Seq_HPCs_Mouse0.83810495
129PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.83725007
130EZH2_27294783_Chip-Seq_NPCs_Mouse0.83557745
131CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.83523744
132CJUN_26792858_Chip-Seq_BT549_Human0.83052576
133PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82633599
134KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.82625422
135TP53_16413492_ChIP-PET_HCT116_Human0.82081155
136GATA3_26560356_Chip-Seq_TH1_Human0.81980975
137KLF4_18555785_Chip-Seq_ESCs_Mouse0.81635741
138* TP63_23658742_ChIP-Seq_EP156T_Human0.81578348
139TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.77685918
140NANOG_18555785_ChIP-Seq_MESCs_Mouse0.77031423
141BMI1_23680149_ChIP-Seq_NPCS_Mouse0.74877190
142PKCTHETA_26484144_Chip-Seq_BREAST_Human0.71137777
143PADI4_21655091_ChIP-ChIP_MCF-7_Human0.70375614
144TP53_22573176_ChIP-Seq_HFKS_Human0.69071745
145SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.68464203
146FOXO3_23340844_ChIP-Seq_DLD1_Human0.68433911
147ARNT_22903824_ChIP-Seq_MCF-7_Human0.67477822
148DROSHA_22980978_ChIP-Seq_HELA_Human0.65524326
149STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.64855571
150AR_20517297_ChIP-Seq_VCAP_Human0.62282726
151* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.62060446
152SMAD3_21741376_ChIP-Seq_EPCs_Human0.61899187
153SOX2_19829295_ChIP-Seq_ESCs_Human0.61633732
154NANOG_19829295_ChIP-Seq_ESCs_Human0.61633732
155REST_21632747_ChIP-Seq_MESCs_Mouse0.61432802
156SOX2_21211035_ChIP-Seq_LN229_Gbm0.60949996
157OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.60931519

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect7.05307751
2MP0005451_abnormal_body_composition6.49155494
3MP0003646_muscle_fatigue5.10231981
4MP0008789_abnormal_olfactory_epithelium4.36895080
5MP0002653_abnormal_ependyma_morphology4.20356077
6MP0005499_abnormal_olfactory_system3.87435567
7MP0005394_taste/olfaction_phenotype3.87435567
8MP0003693_abnormal_embryo_hatching3.66128358
9MP0002102_abnormal_ear_morphology3.64162482
10MP0002139_abnormal_hepatobiliary_system3.27957320
11MP0005395_other_phenotype3.24009310
12MP0010094_abnormal_chromosome_stability3.23044501
13MP0008877_abnormal_DNA_methylation3.20680696
14MP0008057_abnormal_DNA_replication3.02253522
15MP0001119_abnormal_female_reproductive3.01812531
16MP0003699_abnormal_female_reproductive3.01528934
17MP0003111_abnormal_nucleus_morphology2.96464370
18MP0002138_abnormal_hepatobiliary_system2.84814538
19MP0003077_abnormal_cell_cycle2.80542574
20MP0003879_abnormal_hair_cell2.71267679
21MP0010030_abnormal_orbit_morphology2.53281614
22MP0004957_abnormal_blastocyst_morpholog2.38797044
23MP0005408_hypopigmentation2.35671847
24MP0002234_abnormal_pharynx_morphology2.34522676
25MP0001929_abnormal_gametogenesis2.30379054
26MP0000653_abnormal_sex_gland2.26203473
27MP0003183_abnormal_peptide_metabolism2.13159302
28MP0003787_abnormal_imprinting2.12543093
29MP0002210_abnormal_sex_determination2.00042107
30MP0005410_abnormal_fertilization1.76957184
31MP0000566_synostosis1.74017734
32MP0003937_abnormal_limbs/digits/tail_de1.73225747
33MP0001529_abnormal_vocalization1.70200100
34MP0006292_abnormal_olfactory_placode1.68208474
35MP0008932_abnormal_embryonic_tissue1.66244410
36MP0000579_abnormal_nail_morphology1.66043754
37MP0001915_intracranial_hemorrhage1.63872629
38MP0003121_genomic_imprinting1.59497666
39MP0002161_abnormal_fertility/fecundity1.58709312
40MP0004264_abnormal_extraembryonic_tissu1.57891919
41MP0002160_abnormal_reproductive_system1.50106898
42MP0003123_paternal_imprinting1.49248013
43MP0001905_abnormal_dopamine_level1.48671432
44MP0010368_abnormal_lymphatic_system1.46470154
45MP0002249_abnormal_larynx_morphology1.45105022
46MP0008260_abnormal_autophagy1.42813279
47MP0003252_abnormal_bile_duct1.39340206
48MP0010234_abnormal_vibrissa_follicle1.38915289
49MP0005310_abnormal_salivary_gland1.36506681
50MP0001293_anophthalmia1.35586342
51MP0000762_abnormal_tongue_morphology1.32436265
52MP0001145_abnormal_male_reproductive1.30893319
53MP0004185_abnormal_adipocyte_glucose1.28501775
54MP0000350_abnormal_cell_proliferation1.27324297
55MP0010307_abnormal_tumor_latency1.26942663
56MP0000639_abnormal_adrenal_gland1.25575198
57MP0010386_abnormal_urinary_bladder1.25234728
58MP0002085_abnormal_embryonic_tissue1.21829354
59MP0005646_abnormal_pituitary_gland1.13278469
60MP0002233_abnormal_nose_morphology1.11326771
61MP0001984_abnormal_olfaction1.10901417
62MP0004142_abnormal_muscle_tone1.09116681
63MP0001986_abnormal_taste_sensitivity1.07750394
64MP0003950_abnormal_plasma_membrane1.05778619
65MP0004510_myositis1.05440805
66MP0006072_abnormal_retinal_apoptosis1.05363874
67MP0003315_abnormal_perineum_morphology1.04602697
68MP0002019_abnormal_tumor_incidence1.03852543
69MP0001697_abnormal_embryo_size1.02911219
70MP0002295_abnormal_pulmonary_circulatio1.01854871
71MP0005085_abnormal_gallbladder_physiolo1.01755452
72MP0008007_abnormal_cellular_replicative1.01675055
73MP0003453_abnormal_keratinocyte_physiol1.01437046
74MP0001730_embryonic_growth_arrest1.01188031
75MP0002084_abnormal_developmental_patter0.96332197
76MP0002796_impaired_skin_barrier0.94546951
77MP0000427_abnormal_hair_cycle0.93983021
78MP0001849_ear_inflammation0.89777897
79MP0002272_abnormal_nervous_system0.88744683
80MP0006276_abnormal_autonomic_nervous0.86757807
81MP0000462_abnormal_digestive_system0.86499160
82MP0004145_abnormal_muscle_electrophysio0.86482490
83MP0001346_abnormal_lacrimal_gland0.84975118
84MP0000490_abnormal_crypts_of0.81316141
85MP0003705_abnormal_hypodermis_morpholog0.79273531
86MP0002932_abnormal_joint_morphology0.79273253
87MP0003890_abnormal_embryonic-extraembry0.78786705
88MP0005380_embryogenesis_phenotype0.77315827
89MP0001672_abnormal_embryogenesis/_devel0.77315827
90MP0005621_abnormal_cell_physiology0.77025831
91MP0005501_abnormal_skin_physiology0.75734874
92MP0003119_abnormal_digestive_system0.75414099
93MP0003941_abnormal_skin_development0.73955499
94MP0003698_abnormal_male_reproductive0.68320751
95MP0001666_abnormal_nutrient_absorption0.68128061
96MP0001851_eye_inflammation0.68019317
97MP0003868_abnormal_feces_composition0.67148984
98MP0002877_abnormal_melanocyte_morpholog0.67091633
99MP0003755_abnormal_palate_morphology0.67038414
100MP0003329_amyloid_beta_deposits0.66578895
101MP0005551_abnormal_eye_electrophysiolog0.66400214
102MP0001324_abnormal_eye_pigmentation0.65386303
103MP0003763_abnormal_thymus_physiology0.65385807
104MP0009840_abnormal_foam_cell0.65357053
105MP0005647_abnormal_sex_gland0.65262641
106MP0002177_abnormal_outer_ear0.64277125
107MP0001919_abnormal_reproductive_system0.63409096
108MP0001664_abnormal_digestion0.62364367
109MP0005187_abnormal_penis_morphology0.62159459
110MP0004782_abnormal_surfactant_physiolog0.60735611
111MP0000049_abnormal_middle_ear0.59989704
112MP0004859_abnormal_synaptic_plasticity0.59688849
113MP0005075_abnormal_melanosome_morpholog0.59556165
114MP0002168_other_aberrant_phenotype0.59297132
115MP0001963_abnormal_hearing_physiology0.57058723
116MP0003632_abnormal_nervous_system0.56933090
117MP0001502_abnormal_circadian_rhythm0.56599418
118MP0003136_yellow_coat_color0.55150555
119MP0009250_abnormal_appendicular_skeleto0.54622192
120MP0000631_abnormal_neuroendocrine_gland0.54361237
121MP0009697_abnormal_copulation0.53874613
122MP0009379_abnormal_foot_pigmentation0.53642941
123MP0000678_abnormal_parathyroid_gland0.52622243
124MP0005384_cellular_phenotype0.51835513
125MP0005360_urolithiasis0.51781010
126MP0005197_abnormal_uvea_morphology0.51443251
127MP0002089_abnormal_postnatal_growth/wei0.51186915
128MP0008058_abnormal_DNA_repair0.51046883
129MP0009384_cardiac_valve_regurgitation0.50866619
130MP0002116_abnormal_craniofacial_bone0.50499319
131MP0003861_abnormal_nervous_system0.49706936
132MP0005023_abnormal_wound_healing0.49488360
133MP0002080_prenatal_lethality0.49158124
134MP0001485_abnormal_pinna_reflex0.49130250
135MP0004484_altered_response_of0.48468465
136MP0003091_abnormal_cell_migration0.47750999
137MP0005389_reproductive_system_phenotype0.45881224
138MP0002090_abnormal_vision0.45867728
139MP0002928_abnormal_bile_duct0.45625543
140MP0002638_abnormal_pupillary_reflex0.43703021
141MP0003984_embryonic_growth_retardation0.43103804
142MP0010678_abnormal_skin_adnexa0.41664482
143MP0002109_abnormal_limb_morphology0.40947999
144MP0000377_abnormal_hair_follicle0.40514935
145MP0004381_abnormal_hair_follicle0.40361397
146MP0006138_congestive_heart_failure0.39984856
147MP0004043_abnormal_pH_regulation0.39776999
148MP0000015_abnormal_ear_pigmentation0.39587091
149MP0002735_abnormal_chemical_nociception0.39235566
150MP0005503_abnormal_tendon_morphology0.38790990
151MP0002127_abnormal_cardiovascular_syste0.38113554
152MP0005319_abnormal_enzyme/_coenzyme0.37533534
153MP0000026_abnormal_inner_ear0.36001608
154MP0003935_abnormal_craniofacial_develop0.35626202
155MP0003195_calcinosis0.34554801
156MP0001881_abnormal_mammary_gland0.32865487
157MP0004019_abnormal_vitamin_homeostasis0.31263453

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.36064663
2Osteomalacia (HP:0002749)5.32129035
3Breast hypoplasia (HP:0003187)4.94746377
4Papillary thyroid carcinoma (HP:0002895)4.91927623
5Abdominal situs inversus (HP:0003363)4.89025188
6Abnormality of abdominal situs (HP:0011620)4.89025188
7Abnormal gallbladder physiology (HP:0012438)4.73235967
8Cholecystitis (HP:0001082)4.73235967
9Hypophosphatemic rickets (HP:0004912)4.59504018
10Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.52977326
11Premature ovarian failure (HP:0008209)4.33140270
12Azoospermia (HP:0000027)4.26576289
13Cortical dysplasia (HP:0002539)4.23353389
14Chromsome breakage (HP:0040012)4.22345369
15Infertility (HP:0000789)4.21165288
16Septo-optic dysplasia (HP:0100842)4.03663171
17Adrenal hypoplasia (HP:0000835)3.80173314
18Patellar aplasia (HP:0006443)3.77908183
19Median cleft lip (HP:0000161)3.75702029
20Gonadotropin excess (HP:0000837)3.73885265
21Deep venous thrombosis (HP:0002625)3.71762663
22Shawl scrotum (HP:0000049)3.71559405
23Abnormality of the labia minora (HP:0012880)3.70990933
24Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.64100345
25Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.61974639
26Absent septum pellucidum (HP:0001331)3.61929718
27Secondary amenorrhea (HP:0000869)3.59739247
28Impulsivity (HP:0100710)3.59397356
29Chromosomal breakage induced by crosslinking agents (HP:0003221)3.57591120
30Flat capital femoral epiphysis (HP:0003370)3.55668039
31Arterial tortuosity (HP:0005116)3.54448155
32Aplasia/Hypoplasia of the patella (HP:0006498)3.44102766
33Short tibia (HP:0005736)3.42126188
34Conjunctival telangiectasia (HP:0000524)3.37026031
35Abnormal spermatogenesis (HP:0008669)3.20678681
36Enlarged penis (HP:0000040)3.19352081
37Aplasia/Hypoplasia of the sternum (HP:0006714)3.17677458
38Facial hemangioma (HP:0000329)3.08738527
39Vascular tortuosity (HP:0004948)3.05977284
40Abnormality of the septum pellucidum (HP:0007375)3.03281330
41Abnormality of lateral ventricle (HP:0030047)3.02926590
42Aplasia/Hypoplasia of the tibia (HP:0005772)3.01690270
43Urethral obstruction (HP:0000796)2.99156844
44Insulin-resistant diabetes mellitus (HP:0000831)2.98069476
45Aplasia/Hypoplasia of the breasts (HP:0010311)2.92085464
46Rhabdomyosarcoma (HP:0002859)2.91107336
47Muscle stiffness (HP:0003552)2.90389800
48Breast aplasia (HP:0100783)2.89745064
49Spinal cord compression (HP:0002176)2.86739730
50Spondylolisthesis (HP:0003302)2.85534725
51Abnormality of the fingertips (HP:0001211)2.81634586
52Generalized aminoaciduria (HP:0002909)2.81564993
53Hypergonadotropic hypogonadism (HP:0000815)2.80375744
54Fair hair (HP:0002286)2.79712284
55Hypokinesia (HP:0002375)2.79160992
56Proximal tubulopathy (HP:0000114)2.75975931
57Abnormality of chromosome segregation (HP:0002916)2.74273300
58Overlapping toe (HP:0001845)2.73793280
59Chronic bronchitis (HP:0004469)2.73571886
60Loss of speech (HP:0002371)2.73248738
61Capillary hemangiomas (HP:0005306)2.72322567
62Sandal gap (HP:0001852)2.71346547
63Stillbirth (HP:0003826)2.70532881
64Metaphyseal irregularity (HP:0003025)2.69935765
65Abnormality of the vasculature of the conjunctiva (HP:0008054)2.68022137
66Pulmonary fibrosis (HP:0002206)2.61438688
67Sensory axonal neuropathy (HP:0003390)2.58035022
68Diminished motivation (HP:0000745)2.54834906
69Apathy (HP:0000741)2.54139010
70Thyroid carcinoma (HP:0002890)2.49561119
71Aplasia/Hypoplasia of the macula (HP:0008059)2.45823798
72Oligodactyly (hands) (HP:0001180)2.43356915
73Lower limb hyperreflexia (HP:0002395)2.42132101
74Skin pits (HP:0100276)2.41600857
75Acute myeloid leukemia (HP:0004808)2.40990270
76Intrahepatic cholestasis (HP:0001406)2.39798344
77Abnormality of chromosome stability (HP:0003220)2.33705306
78Truncal obesity (HP:0001956)2.32006535
79Ankle contracture (HP:0006466)2.31213697
80Fibular aplasia (HP:0002990)2.28686373
81Abnormal lung lobation (HP:0002101)2.28218425
82Abnormality of the proximal phalanges of the hand (HP:0009834)2.26936168
83Aplasia/Hypoplasia of the tongue (HP:0010295)2.23857361
84Aplasia/Hypoplasia affecting the retina (HP:0008061)2.23735258
85Myokymia (HP:0002411)2.23238330
86Hypoplastic iliac wings (HP:0002866)2.21271491
87Bile duct proliferation (HP:0001408)2.20814335
88Abnormal biliary tract physiology (HP:0012439)2.20814335
89Abnormality of aromatic amino acid family metabolism (HP:0004338)2.19769591
90Abnormality of alanine metabolism (HP:0010916)2.19535308
91Hyperalaninemia (HP:0003348)2.19535308
92Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.19535308
93Posterior subcapsular cataract (HP:0007787)2.19374901
94Maternal diabetes (HP:0009800)2.16234809
95Abnormality of placental membranes (HP:0011409)2.16121305
96Amniotic constriction ring (HP:0009775)2.16121305
97Fetal akinesia sequence (HP:0001989)2.15129950
98Primary amenorrhea (HP:0000786)2.14808111
99Combined immunodeficiency (HP:0005387)2.13900810
100Hydroureter (HP:0000072)2.11594528
101Neoplasm of striated muscle (HP:0009728)2.11254073
102Aplasia of the musculature (HP:0100854)2.10908490
103Rib fusion (HP:0000902)2.10554141
104Aplasia/Hypoplasia involving the musculature (HP:0001460)2.09600633
105Supernumerary spleens (HP:0009799)2.09246349
106Striae distensae (HP:0001065)2.09132620
107Abnormality of calcium-phosphate metabolism (HP:0100530)2.08294542
108Heterotopia (HP:0002282)2.07493167
109Abnormal ciliary motility (HP:0012262)2.06461224
110Anhidrosis (HP:0000970)2.05555760
111Diastasis recti (HP:0001540)2.05528689
112Dysdiadochokinesis (HP:0002075)2.03109144
113Oligodactyly (HP:0012165)2.02889978
114Nausea (HP:0002018)2.01689983
115Congenital sensorineural hearing impairment (HP:0008527)2.01618775
116Chin dimple (HP:0010751)2.01194117
117Small intestinal stenosis (HP:0012848)2.00504321
118Duodenal stenosis (HP:0100867)2.00504321
119Male infertility (HP:0003251)10.5956517
120Aplastic anemia (HP:0001915)1.98913340
121Abnormality of the fovea (HP:0000493)1.98826860
122Generalized hypopigmentation of hair (HP:0011358)1.98458346
123Short 1st metacarpal (HP:0010034)1.97413758
124Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.97413758
125Abnormality of monocarboxylic acid metabolism (HP:0010996)1.96975935
126Abnormality of the epiphysis of the femoral head (HP:0010574)1.95461917
127Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.94395955
128Bundle branch block (HP:0011710)1.93948551
129Cranial hyperostosis (HP:0004437)1.91900808
130Anterior segment dysgenesis (HP:0007700)1.90817688
131Hypoplasia of the fovea (HP:0007750)1.90139528
132Aplasia/Hypoplasia of the fovea (HP:0008060)1.90139528
133Hyperglycemia (HP:0003074)1.90014862
134Limb hypertonia (HP:0002509)1.89519881
135Aplasia/Hypoplasia of the uvula (HP:0010293)1.88419473
136Bicornuate uterus (HP:0000813)1.88111936
137Microglossia (HP:0000171)1.87824466
138Hypohidrosis (HP:0000966)1.87498126
139Absent hand (HP:0004050)1.87069923
140Absent radius (HP:0003974)1.86996121
141Embryonal renal neoplasm (HP:0011794)1.86705237
142Absent forearm bone (HP:0003953)1.86255960
143Aplasia involving forearm bones (HP:0009822)1.86255960
144Rickets (HP:0002748)1.86223664
145Hip contracture (HP:0003273)1.86017846
146Wrist flexion contracture (HP:0001239)1.85914015
147Sloping forehead (HP:0000340)1.85336479
148Aplasia involving bones of the upper limbs (HP:0009823)1.85288241
149Aplasia of the phalanges of the hand (HP:0009802)1.85288241
150Aplasia involving bones of the extremities (HP:0009825)1.85288241
151Abnormality of cochlea (HP:0000375)1.85206766
152Abnormality of the intervertebral disk (HP:0005108)1.84906257
153Lip pit (HP:0100267)1.84777939
154Abnormality of the preputium (HP:0100587)1.83807993
155Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.82793299
156Short thumb (HP:0009778)1.81366255
157Nonprogressive disorder (HP:0003680)1.81265914
158Nephroblastoma (Wilms tumor) (HP:0002667)1.80623984
159Malnutrition (HP:0004395)1.79943238
160Abnormality of the femoral head (HP:0003368)1.79026579
161Rhinitis (HP:0012384)1.78843984
162Myelodysplasia (HP:0002863)1.77493526
163Abnormality of the phalanges of the hallux (HP:0010057)1.76971555
164Abnormality of the clitoris (HP:0000056)1.76963891
165Neoplasm of the oral cavity (HP:0100649)1.75707087
166Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.75391386
167Abnormality of femoral epiphyses (HP:0006499)1.75391386
168Ectopic kidney (HP:0000086)1.72754758
169Cystic hygroma (HP:0000476)1.72434912
170Posterior embryotoxon (HP:0000627)1.71385170
171Carpal bone hypoplasia (HP:0001498)1.69199905

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MOS5.55736862
2BMPR25.41103160
3TAOK34.61207543
4LATS14.16311876
5MAP3K64.05092533
6LATS23.47592519
7KSR22.98942879
8PLK42.88269869
9MAP3K92.86117563
10TTK2.81766048
11NEK62.79223394
12STK38L2.78075152
13MAP3K132.51171549
14ERBB42.45286223
15CDC72.20534101
16ARAF2.19389497
17BRAF2.13004557
18MET2.12577733
19CDK81.94338925
20EIF2AK31.94084649
21RAF11.94068992
22MUSK1.93989431
23TAOK11.86563611
24EEF2K1.77830109
25CDK91.51756998
26MELK1.51177854
27DYRK21.47336182
28PRKCI1.47043410
29STK101.45326208
30PRKD31.42378680
31CDK121.32209535
32STK31.21183074
33MAP3K41.16334077
34TRIM281.15776048
35ZAK1.15198666
36KSR11.14478890
37MAPKAPK31.12148376
38PAK61.11855038
39BUB11.11336205
40TNIK1.10435524
41PLK11.06621242
42CHEK21.06268395
43PIM11.02030275
44NEK21.01229348
45NLK0.96087650
46MAP3K80.93528315
47MAPK130.92788014
48CSNK1G10.91264843
49DMPK0.86900506
50MST40.85957540
51RET0.85770871
52TYRO30.85596367
53TIE10.85283307
54STK380.83713094
55ABL20.77481666
56MAP2K70.71930792
57PRKD20.71052962
58PTK20.68631373
59TNK20.64520772
60BRSK10.63212079
61CSNK1G20.62517806
62CDK190.62407967
63MAPKAPK50.61885144
64CSNK1G30.61770644
65STK390.60062800
66AURKB0.59170715
67MARK30.58757274
68NTRK30.55593357
69ACVR1B0.55053529
70AURKA0.54383868
71VRK10.51288088
72PINK10.50438622
73HIPK20.48878806
74MAP2K40.48464989
75PRKG10.48154943
76WNK10.47808638
77BRSK20.47125262
78CSNK1A1L0.47029094
79LRRK20.46230964
80NUAK10.44052426
81PRKAA10.43841238
82PRKAA20.41312707
83TGFBR10.40664206
84SGK20.40356120
85NEK10.38259129
86MAP3K50.36456177
87PKN10.34234555
88TLK10.33229244
89MARK20.33159127
90MAP3K10.32370595
91SGK4940.32188918
92SGK2230.32188918
93CDK40.31897023
94PLK30.31048948
95PRKCZ0.29815312
96PDK10.29555831
97ATM0.27377293
98LMTK20.26625078
99BMPR1B0.26148771
100ABL10.24320936
101CHUK0.24183003
102CAMK2A0.23996547
103PRKACB0.23973742
104CHEK10.23838596
105CDK50.23795521
106CSNK1E0.23217934
107CDK70.23153754
108NTRK20.22692088
109PRKACA0.22479567
110MAPK110.22137227
111PLK20.20986844
112TRPM70.20916391
113EGFR0.20401766
114MAP2K10.20302207
115OXSR10.20092648
116STK240.20057125
117AKT20.19433021
118CDK10.19432214
119EPHA30.18075232
120MTOR0.17637473
121NEK90.16780941
122RPS6KB20.16288298
123CDK11A0.15544684
124GSK3B0.14551177
125EIF2AK20.14392876
126CSNK1D0.14318541
127CDK20.14285813
128EIF2AK10.13566177
129EPHA40.12409447
130PDPK10.12252651
131PAK10.11919084
132SRPK10.11564938
133SGK30.11545480
134CDK30.11305921
135KIT0.10829512
136CDK180.09451340
137PBK0.09281223
138JAK20.08542178
139JAK30.07295503
140TRIB30.06097412
141ROCK10.06090429
142MAPK10.06048700
143AKT10.05827921
144ATR0.05727203
145CDK150.04814949

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049134.52936315
2Cell cycle_Homo sapiens_hsa041104.19285689
3RNA degradation_Homo sapiens_hsa030183.87166955
4Caffeine metabolism_Homo sapiens_hsa002323.69617393
5Basal transcription factors_Homo sapiens_hsa030223.58137290
6Circadian rhythm_Homo sapiens_hsa047103.34507494
7Oocyte meiosis_Homo sapiens_hsa041143.12488320
8Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.67373480
9Pancreatic cancer_Homo sapiens_hsa052122.44004025
10Vitamin B6 metabolism_Homo sapiens_hsa007502.25951345
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.20240169
12Linoleic acid metabolism_Homo sapiens_hsa005912.17510394
13Olfactory transduction_Homo sapiens_hsa047402.12077909
14Ether lipid metabolism_Homo sapiens_hsa005652.05640588
15TGF-beta signaling pathway_Homo sapiens_hsa043501.99169210
16Base excision repair_Homo sapiens_hsa034101.98483053
17Fanconi anemia pathway_Homo sapiens_hsa034601.84704439
18Homologous recombination_Homo sapiens_hsa034401.83083494
19Dorso-ventral axis formation_Homo sapiens_hsa043201.82509557
20Non-homologous end-joining_Homo sapiens_hsa034501.79733168
21GnRH signaling pathway_Homo sapiens_hsa049121.70382729
22p53 signaling pathway_Homo sapiens_hsa041151.58579586
23DNA replication_Homo sapiens_hsa030301.53979643
24RNA transport_Homo sapiens_hsa030131.53356777
25MicroRNAs in cancer_Homo sapiens_hsa052061.47325707
26Colorectal cancer_Homo sapiens_hsa052101.45375492
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.41467727
28Prolactin signaling pathway_Homo sapiens_hsa049171.40547730
29RNA polymerase_Homo sapiens_hsa030201.35779032
30Folate biosynthesis_Homo sapiens_hsa007901.27942669
31Nucleotide excision repair_Homo sapiens_hsa034201.27888345
32Choline metabolism in cancer_Homo sapiens_hsa052311.24349408
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.19533058
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14220826
35mRNA surveillance pathway_Homo sapiens_hsa030151.11858311
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.11211475
37Phototransduction_Homo sapiens_hsa047441.10063594
38Mismatch repair_Homo sapiens_hsa034301.04518632
39Fatty acid elongation_Homo sapiens_hsa000621.04009441
40Long-term depression_Homo sapiens_hsa047301.02268469
41ABC transporters_Homo sapiens_hsa020101.02073412
42Nicotine addiction_Homo sapiens_hsa050331.01376517
43VEGF signaling pathway_Homo sapiens_hsa043701.00282451
44Hippo signaling pathway_Homo sapiens_hsa043900.95133197
45Adherens junction_Homo sapiens_hsa045200.92168225
46Renal cell carcinoma_Homo sapiens_hsa052110.91492052
47Thyroid cancer_Homo sapiens_hsa052160.90180919
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.87013480
49FoxO signaling pathway_Homo sapiens_hsa040680.86150745
50Notch signaling pathway_Homo sapiens_hsa043300.84551453
51Bile secretion_Homo sapiens_hsa049760.81790128
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80564958
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80483228
54Glycerophospholipid metabolism_Homo sapiens_hsa005640.79676286
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.77008387
56Ras signaling pathway_Homo sapiens_hsa040140.76662032
57Endometrial cancer_Homo sapiens_hsa052130.76319718
58mTOR signaling pathway_Homo sapiens_hsa041500.76110471
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75389141
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75084994
61Inositol phosphate metabolism_Homo sapiens_hsa005620.74086022
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72121790
63Morphine addiction_Homo sapiens_hsa050320.71561039
64Viral carcinogenesis_Homo sapiens_hsa052030.70793901
65Chronic myeloid leukemia_Homo sapiens_hsa052200.67308021
66GABAergic synapse_Homo sapiens_hsa047270.66465889
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.66220816
68Bladder cancer_Homo sapiens_hsa052190.66132066
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63872727
70MAPK signaling pathway_Homo sapiens_hsa040100.61388394
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61317402
72Synaptic vesicle cycle_Homo sapiens_hsa047210.60722060
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.59426349
74HTLV-I infection_Homo sapiens_hsa051660.59216712
75Non-small cell lung cancer_Homo sapiens_hsa052230.58044983
76Estrogen signaling pathway_Homo sapiens_hsa049150.57882633
77Other glycan degradation_Homo sapiens_hsa005110.57665138
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57537667
79Vitamin digestion and absorption_Homo sapiens_hsa049770.54887223
80Small cell lung cancer_Homo sapiens_hsa052220.53700628
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51236644
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49952451
83Taste transduction_Homo sapiens_hsa047420.48603924
84Pyrimidine metabolism_Homo sapiens_hsa002400.48178089
85Serotonergic synapse_Homo sapiens_hsa047260.44371775
86Glutamatergic synapse_Homo sapiens_hsa047240.44329211
87Wnt signaling pathway_Homo sapiens_hsa043100.44176979
88Hepatitis B_Homo sapiens_hsa051610.44130360
89Shigellosis_Homo sapiens_hsa051310.43502633
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43175174
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42467155
92ErbB signaling pathway_Homo sapiens_hsa040120.42182297
93Purine metabolism_Homo sapiens_hsa002300.39533687
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37580541
95Prostate cancer_Homo sapiens_hsa052150.37412952
96Arachidonic acid metabolism_Homo sapiens_hsa005900.37359159
97Glioma_Homo sapiens_hsa052140.36435819
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36223972
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.35034752
100Sphingolipid metabolism_Homo sapiens_hsa006000.32808489
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.30901608
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30563722
103Propanoate metabolism_Homo sapiens_hsa006400.30379972
104cAMP signaling pathway_Homo sapiens_hsa040240.25582840
105Herpes simplex infection_Homo sapiens_hsa051680.25361836
106Hedgehog signaling pathway_Homo sapiens_hsa043400.24863198
107Pathways in cancer_Homo sapiens_hsa052000.24693123
108Gap junction_Homo sapiens_hsa045400.24297213
109Tight junction_Homo sapiens_hsa045300.23813427
110Melanoma_Homo sapiens_hsa052180.23510324
111Oxytocin signaling pathway_Homo sapiens_hsa049210.23498032
112Regulation of autophagy_Homo sapiens_hsa041400.23417797
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.20729824
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.18410131
115Drug metabolism - other enzymes_Homo sapiens_hsa009830.18398714
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.16442692
117Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.15995478
118Huntingtons disease_Homo sapiens_hsa050160.14566426
119Arginine and proline metabolism_Homo sapiens_hsa003300.13905146
120TNF signaling pathway_Homo sapiens_hsa046680.13773388
121Protein digestion and absorption_Homo sapiens_hsa049740.13064529
122Glucagon signaling pathway_Homo sapiens_hsa049220.12944980
123Arginine biosynthesis_Homo sapiens_hsa002200.12211011
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.11779527
125AMPK signaling pathway_Homo sapiens_hsa041520.11348272
126Phagosome_Homo sapiens_hsa041450.10387398
127B cell receptor signaling pathway_Homo sapiens_hsa046620.09888091
128Spliceosome_Homo sapiens_hsa030400.08085651
129Aldosterone synthesis and secretion_Homo sapiens_hsa049250.06828002
130Long-term potentiation_Homo sapiens_hsa047200.06591471
131Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.05002390
132Cholinergic synapse_Homo sapiens_hsa047250.04867320
133Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.04069244
134Epstein-Barr virus infection_Homo sapiens_hsa051690.03431027
135Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.03189323
136Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.01614078
137Pyruvate metabolism_Homo sapiens_hsa006200.00612977

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