BCL2L11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by organism of defense response of other organism involved in symbiotic interact5.49940018
2modulation by symbiont of host immune response (GO:0052553)5.49940018
3positive regulation by symbiont of host defense response (GO:0052509)5.49940018
4modulation by symbiont of host defense response (GO:0052031)5.49940018
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.49940018
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.49940018
7positive regulation of gamma-delta T cell activation (GO:0046645)4.86042067
8response to muramyl dipeptide (GO:0032495)4.48516773
9regulation of interleukin-12 biosynthetic process (GO:0045075)4.37543271
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.32789759
11negative thymic T cell selection (GO:0045060)4.30144255
12negative T cell selection (GO:0043383)4.26535651
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.24891545
14NIK/NF-kappaB signaling (GO:0038061)4.15089857
15response to peptidoglycan (GO:0032494)4.10590635
16neutrophil activation involved in immune response (GO:0002283)4.05062046
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.00135159
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.88876717
19positive regulation of interferon-alpha production (GO:0032727)3.87304773
20thymic T cell selection (GO:0045061)3.84719625
21regulation of interferon-alpha production (GO:0032647)3.78795938
22regulation of interferon-beta biosynthetic process (GO:0045357)3.76603077
23T cell selection (GO:0045058)3.71441372
24macrophage activation involved in immune response (GO:0002281)3.63984880
25B cell receptor signaling pathway (GO:0050853)3.62824286
26leukocyte aggregation (GO:0070486)3.62554678
27germinal center formation (GO:0002467)3.57934791
28natural killer cell mediated cytotoxicity (GO:0042267)3.57848115
29natural killer cell mediated immunity (GO:0002228)3.57848115
30positive regulation of chemokine biosynthetic process (GO:0045080)3.55360636
31regulation of gamma-delta T cell activation (GO:0046643)3.55296974
32positive regulation of heat generation (GO:0031652)3.55283498
33response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.53098509
34response to host immune response (GO:0052572)3.53098509
35response to interleukin-15 (GO:0070672)3.50976847
36positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.44431675
37positive regulation of interleukin-1 beta secretion (GO:0050718)3.43019920
38positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.42192825
39positive thymic T cell selection (GO:0045059)3.42123149
40positive regulation of interleukin-12 production (GO:0032735)3.42063316
41regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.41813505
42negative regulation of T cell mediated immunity (GO:0002710)3.41564869
43myeloid dendritic cell differentiation (GO:0043011)3.38259090
44histone H3-K36 demethylation (GO:0070544)3.37572584
45regulation of B cell receptor signaling pathway (GO:0050855)3.37237899
46immunoglobulin mediated immune response (GO:0016064)3.32125783
47negative regulation of erythrocyte differentiation (GO:0045647)3.31802964
48response to host defenses (GO:0052200)3.30883394
49response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.30883394
50response to host (GO:0075136)3.30883394
51positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.30076548
52myeloid dendritic cell activation (GO:0001773)3.29421930
53lipopolysaccharide-mediated signaling pathway (GO:0031663)3.28778982
54neutrophil mediated immunity (GO:0002446)3.27545767
55negative regulation of lymphocyte mediated immunity (GO:0002707)3.26116804
56I-kappaB phosphorylation (GO:0007252)3.25348228
57detection of other organism (GO:0098543)3.24781964
58regulation of gamma-delta T cell differentiation (GO:0045586)3.23375918
59granulocyte activation (GO:0036230)3.22669232
60hepatocyte apoptotic process (GO:0097284)3.21689911
61positive regulation of interferon-beta production (GO:0032728)3.21101871
62cellular response to interleukin-15 (GO:0071350)3.21015695
63activated T cell proliferation (GO:0050798)3.19963637
64negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.17871173
65neutrophil activation (GO:0042119)3.17396017
66regulation of T cell tolerance induction (GO:0002664)3.15226288
67positive regulation of interleukin-1 secretion (GO:0050716)3.14725718
68regulation of fever generation (GO:0031620)3.14612578
69detection of bacterium (GO:0016045)3.14594120
70negative regulation of interleukin-12 production (GO:0032695)3.14481860
71CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.13667781
72positive regulation of granulocyte differentiation (GO:0030854)3.12419047
73regulation of interleukin-1 beta secretion (GO:0050706)3.12024403
74CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.10718156
75T-helper cell differentiation (GO:0042093)3.10718156
76cytokine secretion (GO:0050663)3.10441417
77regulation of chronic inflammatory response (GO:0002676)3.09843878
78detection of molecule of bacterial origin (GO:0032490)3.09506855
79regulation of histone H3-K27 methylation (GO:0061085)3.05835596
80positive regulation of B cell differentiation (GO:0045579)3.05473153
81defense response to protozoan (GO:0042832)3.05443162
82positive regulation of humoral immune response (GO:0002922)3.05380585
83* modulation by symbiont of host cellular process (GO:0044068)3.04698344
84negative regulation of interleukin-1 beta production (GO:0032691)3.02839584
85regulation of interleukin-12 production (GO:0032655)3.01862542
86production of molecular mediator involved in inflammatory response (GO:0002532)2.99208055
87positive regulation of cellular amide metabolic process (GO:0034250)2.97911418
88positive regulation of antigen processing and presentation (GO:0002579)2.95198324
89respiratory burst (GO:0045730)2.94553485
90regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.93988550
91regulation of natural killer cell mediated immunity (GO:0002715)2.93988550
92regulation of dendritic cell antigen processing and presentation (GO:0002604)2.93248105
93regulation of vitamin D biosynthetic process (GO:0060556)2.92915793
94detection of biotic stimulus (GO:0009595)2.91572249
95regulation of alpha-beta T cell proliferation (GO:0046640)2.90837562
96leukocyte cell-cell adhesion (GO:0007159)2.90432131
97negative regulation of cell killing (GO:0031342)2.89484728
98negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.89484728
99regulation of interleukin-2 biosynthetic process (GO:0045076)2.88702484
100regulation of necroptotic process (GO:0060544)2.86953293
101interferon-gamma production (GO:0032609)2.86804716
102regulation of tolerance induction (GO:0002643)2.86176594
103microglial cell activation (GO:0001774)2.85934554
104myeloid cell activation involved in immune response (GO:0002275)2.85861378
105interferon-gamma-mediated signaling pathway (GO:0060333)2.85718171
106positive regulation of interleukin-1 beta production (GO:0032731)2.85387710
107regulation of type I interferon-mediated signaling pathway (GO:0060338)2.85178513
108positive regulation of interleukin-2 production (GO:0032743)2.85083953
109positive regulation of alpha-beta T cell proliferation (GO:0046641)2.84074214
110positive regulation of cytokine biosynthetic process (GO:0042108)2.83743870
111negative regulation of leukocyte mediated immunity (GO:0002704)2.81785981
112positive regulation of isotype switching (GO:0045830)2.80518845
1133-UTR-mediated mRNA stabilization (GO:0070935)2.80487099
114regulation of T cell mediated cytotoxicity (GO:0001914)2.79747222
115positive regulation of B cell mediated immunity (GO:0002714)2.79649819
116positive regulation of immunoglobulin mediated immune response (GO:0002891)2.79649819
117positive T cell selection (GO:0043368)2.78983960
118regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.78130029
119* B cell homeostasis (GO:0001782)2.78030302
120response to protozoan (GO:0001562)2.77603048
121wound healing, spreading of epidermal cells (GO:0035313)2.77378271
122tolerance induction (GO:0002507)2.77027411
123negative regulation of lipid storage (GO:0010888)2.77011716
124antigen processing and presentation via MHC class Ib (GO:0002475)2.76831277
125response to type I interferon (GO:0034340)2.76786398
126negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.75513729
127alpha-beta T cell differentiation involved in immune response (GO:0002293)2.75000764
128alpha-beta T cell activation involved in immune response (GO:0002287)2.75000764
129T cell differentiation involved in immune response (GO:0002292)2.75000764
130cellular response to type I interferon (GO:0071357)2.74505694
131type I interferon signaling pathway (GO:0060337)2.74505694
132positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.73304842
133regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.73099224
134T cell migration (GO:0072678)2.72446485
135cellular extravasation (GO:0045123)2.71929264
136regulation of integrin activation (GO:0033623)2.71560261
137antigen receptor-mediated signaling pathway (GO:0050851)2.71292698
138regulation of interleukin-1 secretion (GO:0050704)2.70568062
139cell adhesion mediated by integrin (GO:0033627)2.70487973
140regulation of chemokine biosynthetic process (GO:0045073)2.70481517
141regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.68549968
142necroptotic process (GO:0070266)2.67816206
143regulation of B cell differentiation (GO:0045577)2.67806377
144positive regulation of T cell mediated cytotoxicity (GO:0001916)2.67662727
145macrophage activation (GO:0042116)2.67365757
146regulation of B cell proliferation (GO:0030888)2.67194414
147antigen processing and presentation of endogenous antigen (GO:0019883)2.66540972
148positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.66335299
149natural killer cell activation involved in immune response (GO:0002323)2.66201942
150positive regulation of B cell proliferation (GO:0030890)2.64155936
151regulation of regulatory T cell differentiation (GO:0045589)2.64085036
152B cell proliferation (GO:0042100)2.63973901
153positive regulation of tolerance induction (GO:0002645)2.63780483
154negative regulation of T-helper cell differentiation (GO:0045623)2.63591134
155negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.63591134
156negative regulation of cytokine production involved in immune response (GO:0002719)2.63211286

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.48128950
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.39416836
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.73878864
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.61875355
5EGR1_19374776_ChIP-ChIP_THP-1_Human4.42672416
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.21424874
7* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.91036135
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.77749981
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.60124314
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.36555571
11E2F7_22180533_ChIP-Seq_HELA_Human3.36386299
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.36107139
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.33796409
14* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.26003246
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.25543251
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.10086679
17* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.94503314
18* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.87240698
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.63045092
20* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.52075610
21* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.31433058
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.22295580
23SCL_19346495_ChIP-Seq_HPC-7_Human2.20520642
24* MYB_26560356_Chip-Seq_TH2_Human2.17450134
25RUNX_20019798_ChIP-Seq_JUKART_Human2.17209508
26BRD4_27068464_Chip-Seq_AML-cells_Mouse2.12107761
27* SPI1_23547873_ChIP-Seq_NB4_Human2.07779286
28ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.99513528
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.98498231
30* VDR_24763502_ChIP-Seq_THP-1_Human1.97627630
31MAF_26560356_Chip-Seq_TH1_Human1.95884425
32VDR_21846776_ChIP-Seq_THP-1_Human1.95139564
33MYB_26560356_Chip-Seq_TH1_Human1.93474857
34MYC_22102868_ChIP-Seq_BL_Human1.90745849
35PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.89564607
36TP63_17297297_ChIP-ChIP_HaCaT_Human1.83615813
37CIITA_25753668_ChIP-Seq_RAJI_Human1.79803147
38PU_27001747_Chip-Seq_BMDM_Mouse1.75575095
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.73908710
40* SPI1_23127762_ChIP-Seq_K562_Human1.72911484
41* VDR_24787735_ChIP-Seq_THP-1_Human1.71673964
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.66448212
43UTX_26944678_Chip-Seq_JUKART_Human1.58911959
44* TCF7_22412390_ChIP-Seq_EML_Mouse1.56342320
45* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.55535318
46* KDM2B_26808549_Chip-Seq_JURKAT_Human1.54212369
47* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51184937
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.46884405
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.46505342
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.46110661
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.42247426
52CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39398007
53* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38066950
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.36887017
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.36454888
56GATA3_27048872_Chip-Seq_THYMUS_Human1.35351742
57GATA1_19941827_ChIP-Seq_MEL_Mouse1.30589736
58* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.30420852
59KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.27772144
60* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27488659
61GATA1_19941826_ChIP-Seq_K562_Human1.25282669
62CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22768101
63GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22067273
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17857981
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.14787259
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.13723257
67* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13639402
68* GATA2_21666600_ChIP-Seq_HMVEC_Human1.12644571
69SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11069681
70GATA3_26560356_Chip-Seq_TH2_Human1.10808016
71TFEB_21752829_ChIP-Seq_HELA_Human1.10383071
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09551268
73GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08503349
74ELK3_25401928_ChIP-Seq_HUVEC_Human1.07370005
75* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05674590
76PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04539074
77MAF_26560356_Chip-Seq_TH2_Human1.03829514
78* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02498365
79KDM2B_26808549_Chip-Seq_DND41_Human1.02348151
80* LXR_22292898_ChIP-Seq_THP-1_Human1.01349043
81E2F4_17652178_ChIP-ChIP_JURKAT_Human1.01344092
82CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99289442
83PKCTHETA_26484144_Chip-Seq_BREAST_Human0.98392620
84HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97828360
85* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97616300
86CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95798251
87* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.94896230
88* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.94896230
89RACK7_27058665_Chip-Seq_MCF-7_Human0.94894102
90CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92777896
91TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92391744
92LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92293429
93* KDM2B_26808549_Chip-Seq_K562_Human0.92135562
94* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.90984352
95TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90382477
96GATA1_22025678_ChIP-Seq_K562_Human0.88878612
97* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88623804
98RUNX1_27514584_Chip-Seq_MCF-7_Human0.87928682
99BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.87064784
100* FOXO3_23340844_ChIP-Seq_DLD1_Human0.85882337
101FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.85327661
102TP63_19390658_ChIP-ChIP_HaCaT_Human0.82960715
103CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.82846155
104CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.79597178
105* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78502034
106KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.77987389
107KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.77987389
108KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.77987389
109SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.77664338
110* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77270025
111* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.76761002
112RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.76147903
113ESR1_21235772_ChIP-Seq_MCF-7_Human0.76105743
114BRD4_25478319_ChIP-Seq_HGPS_Human0.75095852
115TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.74750358
116* NCOR1_26117541_ChIP-Seq_K562_Human0.74409461
117STAT6_21828071_ChIP-Seq_BEAS2B_Human0.73574041
118* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72223877
119KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.68491445
120SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67590865
121GATA2_19941826_ChIP-Seq_K562_Human0.67467384
122ELK1_19687146_ChIP-ChIP_HELA_Human0.67188374
123PPAR_26484153_Chip-Seq_NCI-H1993_Human0.66826639

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.96339118
2MP0001835_abnormal_antigen_presentation3.93339189
3MP0003436_decreased_susceptibility_to3.30318357
4MP0003303_peritoneal_inflammation3.09703066
5MP0009785_altered_susceptibility_to3.09491474
6* MP0005000_abnormal_immune_tolerance2.88101571
7MP0001790_abnormal_immune_system2.80018222
8MP0005387_immune_system_phenotype2.80018222
9MP0009278_abnormal_bone_marrow2.78361350
10* MP0001800_abnormal_humoral_immune2.77961657
11MP0000685_abnormal_immune_system2.76846891
12MP0005671_abnormal_response_to2.76314761
13MP0002419_abnormal_innate_immunity2.76268937
14MP0002148_abnormal_hypersensitivity_rea2.73698016
15* MP0002452_abnormal_antigen_presenting2.69743443
16MP0006082_CNS_inflammation2.63198108
17* MP0002723_abnormal_immune_serum2.55674016
18* MP0005025_abnormal_response_to2.53261949
19MP0004510_myositis2.47503732
20MP0004947_skin_inflammation2.38979879
21* MP0001819_abnormal_immune_cell2.30615625
22* MP0002420_abnormal_adaptive_immunity2.28988226
23MP0002009_preneoplasia2.11830625
24MP0003300_gastrointestinal_ulcer2.08416800
25MP0005451_abnormal_body_composition2.07682189
26MP0002405_respiratory_system_inflammati2.03612359
27MP0003448_altered_tumor_morphology1.91913289
28MP0002006_tumorigenesis1.91591017
29MP0003724_increased_susceptibility_to1.89479506
30* MP0002398_abnormal_bone_marrow1.86873215
31MP0003763_abnormal_thymus_physiology1.86020772
32MP0005464_abnormal_platelet_physiology1.83820900
33* MP0000716_abnormal_immune_system1.77737947
34MP0005076_abnormal_cell_differentiation1.77271362
35MP0010155_abnormal_intestine_physiology1.77079508
36MP0001545_abnormal_hematopoietic_system1.75376851
37MP0005397_hematopoietic_system_phenotyp1.75376851
38MP0005058_abnormal_lysosome_morphology1.75171597
39MP0002166_altered_tumor_susceptibility1.73586139
40MP0009333_abnormal_splenocyte_physiolog1.72661722
41MP0001853_heart_inflammation1.72388032
42MP0005174_abnormal_tail_pigmentation1.71082648
43MP0002132_abnormal_respiratory_system1.69419927
44MP0001348_abnormal_lacrimal_gland1.67561942
45* MP0001845_abnormal_inflammatory_respons1.64722924
46MP0003172_abnormal_lysosome_physiology1.64543318
47MP0001533_abnormal_skeleton_physiology1.59095622
48MP0004264_abnormal_extraembryonic_tissu1.58588178
49* MP0000689_abnormal_spleen_morphology1.55563430
50MP0003656_abnormal_erythrocyte_physiolo1.49041701
51* MP0002722_abnormal_immune_system1.48381825
52* MP0002429_abnormal_blood_cell1.43931264
53MP0000015_abnormal_ear_pigmentation1.40207723
54MP0010307_abnormal_tumor_latency1.39675541
55MP0000858_altered_metastatic_potential1.38201679
56MP0009764_decreased_sensitivity_to1.31471485
57* MP0000703_abnormal_thymus_morphology1.30849529
58MP0005310_abnormal_salivary_gland1.30154965
59MP0001873_stomach_inflammation1.28109529
60MP0002998_abnormal_bone_remodeling1.26454962
61MP0008469_abnormal_protein_level1.25352658
62MP0003183_abnormal_peptide_metabolism1.20858343
63MP0004808_abnormal_hematopoietic_stem1.20088833
64MP0002933_joint_inflammation1.16734838
65MP0010352_gastrointestinal_tract_polyps1.16660328
66MP0002396_abnormal_hematopoietic_system1.16457102
67MP0003566_abnormal_cell_adhesion1.16403956
68MP0003453_abnormal_keratinocyte_physiol1.12684669
69MP0001851_eye_inflammation1.12609991
70MP0003828_pulmonary_edema1.12473145
71MP0008961_abnormal_basal_metabolism1.07168420
72MP0000490_abnormal_crypts_of1.01350673
73MP0000371_diluted_coat_color1.00711811
74MP0008057_abnormal_DNA_replication0.99027924
75MP0000343_altered_response_to0.98159670
76MP0003091_abnormal_cell_migration0.97596384
77MP0009115_abnormal_fat_cell0.95939176
78MP0002254_reproductive_system_inflammat0.88894172
79MP0000465_gastrointestinal_hemorrhage0.88731013
80MP0002138_abnormal_hepatobiliary_system0.88728977
81MP0005390_skeleton_phenotype0.87300526
82MP0008004_abnormal_stomach_pH0.87220021
83MP0009763_increased_sensitivity_to0.86885215
84MP0005075_abnormal_melanosome_morpholog0.86297573
85MP0002277_abnormal_respiratory_mucosa0.84015288
86MP0005167_abnormal_blood-brain_barrier0.83274246
87MP0009840_abnormal_foam_cell0.80692946
88MP0005257_abnormal_intraocular_pressure0.80284200
89MP0003878_abnormal_ear_physiology0.78418966
90MP0005377_hearing/vestibular/ear_phenot0.78418966
91MP0008260_abnormal_autophagy0.77655714
92MP0003045_fibrosis0.76246137
93MP0003866_abnormal_defecation0.75706653
94MP0000609_abnormal_liver_physiology0.74405844
95MP0000767_abnormal_smooth_muscle0.72020618
96MP0008995_early_reproductive_senescence0.71781548
97MP0005166_decreased_susceptibility_to0.71312183
98MP0000604_amyloidosis0.70885500
99MP0001663_abnormal_digestive_system0.70231534
100MP0000383_abnormal_hair_follicle0.68677989
101MP0001346_abnormal_lacrimal_gland0.68543943
102MP0004185_abnormal_adipocyte_glucose0.67713042
103MP0003077_abnormal_cell_cycle0.67608202
104MP0000733_abnormal_muscle_development0.67319049
105MP0005023_abnormal_wound_healing0.66530670
106MP0002019_abnormal_tumor_incidence0.66418639
107MP0009765_abnormal_xenobiotic_induced0.66369174
108MP0003795_abnormal_bone_structure0.65053447
109* MP0000313_abnormal_cell_death0.61171711
110MP0005621_abnormal_cell_physiology0.60930625
111MP0001879_abnormal_lymphatic_vessel0.60732443
112MP0001986_abnormal_taste_sensitivity0.59027425
113MP0008007_abnormal_cellular_replicative0.58960652
114MP0001191_abnormal_skin_condition0.57800614
115MP0010094_abnormal_chromosome_stability0.57687478
116* MP0000249_abnormal_blood_vessel0.57274275
117MP0003191_abnormal_cellular_cholesterol0.56390543
118MP0003075_altered_response_to0.55543083
119MP0002163_abnormal_gland_morphology0.55443293
120MP0001919_abnormal_reproductive_system0.54734925
121MP0003221_abnormal_cardiomyocyte_apopto0.54217968
122MP0005666_abnormal_adipose_tissue0.53903317
123MP0009931_abnormal_skin_appearance0.53705556
124MP0004381_abnormal_hair_follicle0.52243098
125MP0003943_abnormal_hepatobiliary_system0.52104235
126MP0002095_abnormal_skin_pigmentation0.50380084
127MP0001915_intracranial_hemorrhage0.49888036

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.30045768
2Stomatitis (HP:0010280)6.17483339
3Recurrent bacterial skin infections (HP:0005406)5.86789869
4Elevated erythrocyte sedimentation rate (HP:0003565)5.68661425
5Eczematoid dermatitis (HP:0000976)5.58047154
6Mediastinal lymphadenopathy (HP:0100721)4.65510844
7Retrobulbar optic neuritis (HP:0100654)4.37093799
8Optic neuritis (HP:0100653)4.37093799
9Gastrointestinal infarctions (HP:0005244)4.15555545
10Recurrent gram-negative bacterial infections (HP:0005420)4.08166950
11Orchitis (HP:0100796)4.06455557
12Abnormality of macrophages (HP:0004311)4.01987288
13Myositis (HP:0100614)4.00412903
14Recurrent fungal infections (HP:0002841)3.94373155
15Autoimmune thrombocytopenia (HP:0001973)3.66499769
16Recurrent skin infections (HP:0001581)3.62950922
17Gingivitis (HP:0000230)3.58121429
18Recurrent viral infections (HP:0004429)3.54351476
19Vasculitis (HP:0002633)3.53963714
20Autoimmune hemolytic anemia (HP:0001890)3.49227548
21Prostate neoplasm (HP:0100787)3.36056030
22Leukocytosis (HP:0001974)3.26416235
23Hematochezia (HP:0002573)3.25133356
24Obstructive lung disease (HP:0006536)3.12271617
25Chronic obstructive pulmonary disease (HP:0006510)3.12271617
26Increased IgE level (HP:0003212)3.11557851
27Pustule (HP:0200039)3.09282011
28Abnormality of T cell number (HP:0011839)3.07760949
29Periodontitis (HP:0000704)3.06350691
30T lymphocytopenia (HP:0005403)3.00252512
31Abnormality of T cell physiology (HP:0011840)2.93789930
32Pulmonary infiltrates (HP:0002113)2.88663283
33Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.88509944
34Thick nail (HP:0001805)2.86363152
35Eosinophilia (HP:0001880)2.84197588
36Recurrent cutaneous fungal infections (HP:0011370)2.79149273
37Chronic mucocutaneous candidiasis (HP:0002728)2.79149273
38Cellulitis (HP:0100658)2.77838148
39Increased cerebral lipofuscin (HP:0011813)2.75529508
40Meningitis (HP:0001287)2.74557861
41Vacuolated lymphocytes (HP:0001922)2.68044665
42Urticaria (HP:0001025)2.63465510
43IgM deficiency (HP:0002850)2.60373857
44Increased neuronal autofluorescent lipopigment (HP:0002074)2.57757761
45Thyroiditis (HP:0100646)2.57515863
46Hypochromic anemia (HP:0001931)2.52988079
47Chest pain (HP:0100749)2.52544855
48Arterial thrombosis (HP:0004420)2.52098698
49Osteomyelitis (HP:0002754)2.51663928
50Keratoconjunctivitis sicca (HP:0001097)2.48662427
51Increased IgM level (HP:0003496)2.43908875
52Chronic otitis media (HP:0000389)2.43171466
53Segmental peripheral demyelination/remyelination (HP:0003481)2.40401675
54Abnormality of the fingertips (HP:0001211)2.40116592
55Interstitial pulmonary disease (HP:0006530)2.33589956
56Verrucae (HP:0200043)2.30919782
57Papilloma (HP:0012740)2.30919782
58Basal ganglia calcification (HP:0002135)2.30278035
59Slow saccadic eye movements (HP:0000514)2.28693958
60Abnormality of eosinophils (HP:0001879)2.27770182
61Recurrent pneumonia (HP:0006532)2.27039996
62Viral hepatitis (HP:0006562)2.26585998
63Premature loss of primary teeth (HP:0006323)2.24514782
64Colitis (HP:0002583)2.24502248
65Hemoptysis (HP:0002105)2.24351335
66Granulocytopenia (HP:0001913)2.23840880
67Keratoconjunctivitis (HP:0001096)2.23093965
68Inflammation of the large intestine (HP:0002037)2.19905353
69Fatigue (HP:0012378)2.17973198
70Severe combined immunodeficiency (HP:0004430)2.17461446
71Amyloidosis (HP:0011034)2.17055994
72Lymphoma (HP:0002665)2.14691466
73Restrictive lung disease (HP:0002091)2.13634104
74Combined immunodeficiency (HP:0005387)2.12256865
75Gingival bleeding (HP:0000225)2.11803254
76Panhypogammaglobulinemia (HP:0003139)2.09686545
77Abnormality of the prostate (HP:0008775)2.08843856
78Amaurosis fugax (HP:0100576)2.06178470
79Abnormality of T cells (HP:0002843)2.04393151
80Abnormality of glycolipid metabolism (HP:0010969)2.04389347
81Abnormality of liposaccharide metabolism (HP:0010968)2.04389347
82Abnormality of glycosphingolipid metabolism (HP:0004343)2.04389347
83Gastrointestinal inflammation (HP:0004386)2.03456646
84Basal cell carcinoma (HP:0002671)2.03036080
85Cheilitis (HP:0100825)2.02605939
86Disinhibition (HP:0000734)2.02391778
87Persistence of primary teeth (HP:0006335)2.02040080
88Gangrene (HP:0100758)2.01686014
89Submucous cleft hard palate (HP:0000176)2.01105488
90Prolonged bleeding time (HP:0003010)1.98715682
91Axonal loss (HP:0003447)1.97840989
92Subacute progressive viral hepatitis (HP:0006572)1.96457145
93Abnormality of cells of the lymphoid lineage (HP:0012140)1.95666008
94Abnormality of B cell number (HP:0010975)1.95016413
95B lymphocytopenia (HP:0010976)1.95016413
96Anorexia (HP:0002039)1.95015620
97Stomach cancer (HP:0012126)1.94717091
98Lymphopenia (HP:0001888)1.94709713
99Recurrent sinusitis (HP:0011108)1.93778084
100Progressive hearing impairment (HP:0001730)1.93581355
101Myocardial infarction (HP:0001658)1.92521921
102Agammaglobulinemia (HP:0004432)1.92305410
103Leukopenia (HP:0001882)1.91034339
104Progressive external ophthalmoplegia (HP:0000590)1.89955037
105Tetraparesis (HP:0002273)1.89156105
106Abnormality of the columella (HP:0009929)1.88095494
107Epistaxis (HP:0000421)1.88034595
108Abnormality of the nasal septum (HP:0000419)1.87931322
109Pulmonary embolism (HP:0002204)1.86533901
110Abnormality of the endocardium (HP:0004306)1.86161640
111Chromosomal breakage induced by crosslinking agents (HP:0003221)1.86151101
112Abnormality of the pleura (HP:0002103)1.85162898
113Chronic diarrhea (HP:0002028)1.84978075
114Abnormality of the peritoneum (HP:0002585)1.84942003
115Recurrent lower respiratory tract infections (HP:0002783)1.84765150
116Progressive sensorineural hearing impairment (HP:0000408)1.84024926
117Hypergammaglobulinemia (HP:0010702)1.83993189
118IgG deficiency (HP:0004315)1.83779287
119Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.83506864
120Acute hepatic failure (HP:0006554)1.82479992
121Neonatal hypoglycemia (HP:0001998)1.82195075
122Spontaneous hematomas (HP:0007420)1.82047851
123Polyneuropathy (HP:0001271)1.81419256
124Arthralgia (HP:0002829)1.80887593
125Metaphyseal cupping (HP:0003021)1.80877162
126Hypoplasia of the thymus (HP:0000778)1.80815202
127Recurrent bronchitis (HP:0002837)1.80773637
128Bone pain (HP:0002653)1.80240520
129IgA deficiency (HP:0002720)1.79652684
130Osteolytic defects of the phalanges of the hand (HP:0009771)1.79647873
131Osteolytic defects of the hand bones (HP:0009699)1.79647873
132Abnormal delayed hypersensitivity skin test (HP:0002963)1.77813729
133Gastrointestinal stroma tumor (HP:0100723)1.77053811
134Skin ulcer (HP:0200042)1.76964954
135Encephalitis (HP:0002383)1.75633174
136Large earlobe (HP:0009748)1.75262851

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.64523003
2PRPF4B3.49499646
3TXK3.47163333
4MAP4K13.45363212
5IRAK33.34894101
6CDK123.00704884
7TBK12.98454294
8TYK22.86033708
9IRAK42.83263129
10IKBKE2.51544900
11IKBKB2.49792280
12JAK32.34755515
13SMG12.15506757
14RIPK42.12258993
15CHUK2.10694870
16TRIB31.95440680
17JAK11.85201768
18MAP3K101.77766499
19ZAP701.76892087
20KIT1.73261251
21BLK1.73022818
22MAP3K131.70895663
23RPS6KA41.63783853
24STK101.62926624
25SIK31.59483995
26SIK21.56962552
27PIM11.54461310
28TAOK31.53701223
29ITK1.51054733
30MARK31.47990506
31HCK1.42184008
32CSK1.29044627
33BRD41.28848761
34BTK1.26583000
35SYK1.26103455
36TEC1.23614725
37LCK1.19012007
38PIM21.13417608
39EPHB11.11440365
40CSF1R1.09674852
41EEF2K1.09602138
42TAOK11.06026803
43ICK1.05162927
44MAP3K11.05069523
45PKN21.00375500
46PTK60.99527135
47STK40.99490852
48TGFBR20.99213598
49KSR20.96497902
50MAP2K20.96342835
51CDK60.94493006
52MARK20.94267641
53CLK10.91358903
54JAK20.90840992
55ERN10.90523306
56FGFR30.89469531
57MST40.89125671
58LYN0.88920690
59MAPK110.86752255
60MAP3K30.84794588
61NLK0.84038817
62NEK90.82340588
63PDK10.81976337
64MAP2K30.81520265
65STK30.80904116
66TTN0.80204723
67EIF2AK20.76765346
68SIK10.76512025
69TNK20.75658016
70YES10.74565179
71INSRR0.74316135
72MELK0.71289161
73EPHA30.70669001
74SGK30.67683020
75FGR0.64905382
76GRK60.64215314
77PASK0.63762776
78TESK20.63599263
79MAP3K50.62559510
80TYRO30.62522822
81EGFR0.61487654
82CDK90.60579641
83ABL10.60051743
84PDPK10.58927209
85PDGFRB0.57990413
86SGK20.57291966
87RIPK10.56445600
88FGFR40.56441145
89PIK3CG0.56335085
90IRAK10.55952581
91MAP3K20.55817418
92TAOK20.55635608
93BMX0.54971894
94WNK10.54518955
95CDK40.54482913
96FES0.54261184
97NEK20.53230659
98CAMKK10.51530350
99NEK60.51221632
100MAPK120.50230008
101CDC42BPA0.47953774
102RPS6KA60.47444000
103CAMK1D0.47325679
104PBK0.47083592
105RPS6KB20.47064411
106PRKCQ0.46413115
107NUAK10.45270203
108MAPK70.45138133
109MAP3K70.45135898
110NME20.44838879
111CDK70.44389163
112MAPKAPK20.43168351
113BMPR20.43146162
114RAF10.42954263
115ATR0.42321699
116MAP3K110.42130783
117LRRK20.41667472
118ALK0.41375999
119RPS6KA20.40875523
120MATK0.39936926
121CAMK1G0.39866285
122RPS6KA50.39478110
123RPS6KC10.36093276
124RPS6KL10.36093276
125TRPM70.34948980
126HIPK20.34651780
127INSR0.34160975
128PAK40.33301980
129MAP3K80.33259834
130GSK3A0.32482354
131PRKCD0.31399649
132MTOR0.29241152
133RPS6KA10.28880397
134IRAK20.27651213

Predicted pathways (KEGG)

RankGene SetZ-score
1NF-kappa B signaling pathway_Homo sapiens_hsa040643.05417680
2Graft-versus-host disease_Homo sapiens_hsa053323.05072529
3Leishmaniasis_Homo sapiens_hsa051402.85612304
4Allograft rejection_Homo sapiens_hsa053302.75078946
5NOD-like receptor signaling pathway_Homo sapiens_hsa046212.65384085
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.42436478
7Osteoclast differentiation_Homo sapiens_hsa043802.40782538
8Measles_Homo sapiens_hsa051622.21120546
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.15812120
10Malaria_Homo sapiens_hsa051442.07303190
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.03620017
12TNF signaling pathway_Homo sapiens_hsa046681.96674233
13Legionellosis_Homo sapiens_hsa051341.94921590
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.90602629
15B cell receptor signaling pathway_Homo sapiens_hsa046621.90203900
16Primary immunodeficiency_Homo sapiens_hsa053401.90031869
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.89101148
18Pertussis_Homo sapiens_hsa051331.80821602
19Asthma_Homo sapiens_hsa053101.79876030
20Tuberculosis_Homo sapiens_hsa051521.76671917
21Influenza A_Homo sapiens_hsa051641.74350352
22Type I diabetes mellitus_Homo sapiens_hsa049401.70625120
23Hematopoietic cell lineage_Homo sapiens_hsa046401.67874680
24T cell receptor signaling pathway_Homo sapiens_hsa046601.65156478
25Toxoplasmosis_Homo sapiens_hsa051451.64206745
26Herpes simplex infection_Homo sapiens_hsa051681.62183959
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.62119406
28Staphylococcus aureus infection_Homo sapiens_hsa051501.61609700
29Rheumatoid arthritis_Homo sapiens_hsa053231.60196364
30Antigen processing and presentation_Homo sapiens_hsa046121.56196114
31* Apoptosis_Homo sapiens_hsa042101.42471597
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.41676753
33African trypanosomiasis_Homo sapiens_hsa051431.39638330
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.38792380
35Autoimmune thyroid disease_Homo sapiens_hsa053201.37229676
36Hepatitis B_Homo sapiens_hsa051611.34623082
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.27790490
38Viral myocarditis_Homo sapiens_hsa054161.24687775
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24041633
40Chronic myeloid leukemia_Homo sapiens_hsa052201.23741849
41Shigellosis_Homo sapiens_hsa051311.21412422
42Endometrial cancer_Homo sapiens_hsa052131.19514441
43Chemokine signaling pathway_Homo sapiens_hsa040621.13648800
44Acute myeloid leukemia_Homo sapiens_hsa052211.11897999
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.11017389
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10726137
47Salmonella infection_Homo sapiens_hsa051321.10448113
48Hepatitis C_Homo sapiens_hsa051601.08679768
49Small cell lung cancer_Homo sapiens_hsa052221.04261028
50Leukocyte transendothelial migration_Homo sapiens_hsa046701.02987551
51Lysosome_Homo sapiens_hsa041421.01707235
52Epstein-Barr virus infection_Homo sapiens_hsa051691.00488988
53Phagosome_Homo sapiens_hsa041450.97464853
54Thyroid cancer_Homo sapiens_hsa052160.96234821
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93660114
56Pancreatic cancer_Homo sapiens_hsa052120.91068989
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90776141
58HTLV-I infection_Homo sapiens_hsa051660.85296477
59Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83052936
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79986327
61Viral carcinogenesis_Homo sapiens_hsa052030.78229386
62* MicroRNAs in cancer_Homo sapiens_hsa052060.76419112
63Amoebiasis_Homo sapiens_hsa051460.76174990
64Other glycan degradation_Homo sapiens_hsa005110.74948639
65Prolactin signaling pathway_Homo sapiens_hsa049170.74629837
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.73091107
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.72426155
68ErbB signaling pathway_Homo sapiens_hsa040120.70156903
69Choline metabolism in cancer_Homo sapiens_hsa052310.68497163
70Notch signaling pathway_Homo sapiens_hsa043300.67784792
71Bladder cancer_Homo sapiens_hsa052190.67584028
72Type II diabetes mellitus_Homo sapiens_hsa049300.67007565
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66466167
74p53 signaling pathway_Homo sapiens_hsa041150.65172816
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64767864
76Prostate cancer_Homo sapiens_hsa052150.63790406
77Non-homologous end-joining_Homo sapiens_hsa034500.62240900
78Insulin signaling pathway_Homo sapiens_hsa049100.59269068
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57727326
80Proteoglycans in cancer_Homo sapiens_hsa052050.55632565
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55363776
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53747654
83Glioma_Homo sapiens_hsa052140.52911330
84Colorectal cancer_Homo sapiens_hsa052100.51105206
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.50599597
86HIF-1 signaling pathway_Homo sapiens_hsa040660.48944429
87Insulin resistance_Homo sapiens_hsa049310.48586562
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48099924
89* FoxO signaling pathway_Homo sapiens_hsa040680.48077484
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47929079
91Platelet activation_Homo sapiens_hsa046110.47849261
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.46660607
93mTOR signaling pathway_Homo sapiens_hsa041500.45858566
94mRNA surveillance pathway_Homo sapiens_hsa030150.44481028
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44297825
96Adherens junction_Homo sapiens_hsa045200.41435655
97Dorso-ventral axis formation_Homo sapiens_hsa043200.41166911
98Renal cell carcinoma_Homo sapiens_hsa052110.40509195
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39972397
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.39959985
101Estrogen signaling pathway_Homo sapiens_hsa049150.39548878
102Caffeine metabolism_Homo sapiens_hsa002320.36620862
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36414718
104MAPK signaling pathway_Homo sapiens_hsa040100.34961885
105VEGF signaling pathway_Homo sapiens_hsa043700.34960633
106Regulation of autophagy_Homo sapiens_hsa041400.34753733
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.32535613
108Lysine degradation_Homo sapiens_hsa003100.31838247
109AMPK signaling pathway_Homo sapiens_hsa041520.31723694
110Non-small cell lung cancer_Homo sapiens_hsa052230.31621205
111Pathways in cancer_Homo sapiens_hsa052000.31224543
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30170538
113Spliceosome_Homo sapiens_hsa030400.28239068
114Homologous recombination_Homo sapiens_hsa034400.26451506
115Inositol phosphate metabolism_Homo sapiens_hsa005620.26255641
116TGF-beta signaling pathway_Homo sapiens_hsa043500.25711036
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.24309016
118Endocytosis_Homo sapiens_hsa041440.23989789
119Focal adhesion_Homo sapiens_hsa045100.22955958
120Fanconi anemia pathway_Homo sapiens_hsa034600.22035652
121Systemic lupus erythematosus_Homo sapiens_hsa053220.21957840

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