BCL2L12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.78977610
2DNA deamination (GO:0045006)5.09962166
3telomere maintenance via semi-conservative replication (GO:0032201)4.77771930
4viral transcription (GO:0019083)4.67913103
5DNA strand elongation involved in DNA replication (GO:0006271)4.66644392
6translational termination (GO:0006415)4.50653087
7DNA strand elongation (GO:0022616)4.45153821
8heterochromatin organization (GO:0070828)4.34405655
9maturation of SSU-rRNA (GO:0030490)4.31804609
10telomere maintenance via recombination (GO:0000722)4.28201931
11DNA replication initiation (GO:0006270)4.22474524
12translational elongation (GO:0006414)4.09528592
13DNA unwinding involved in DNA replication (GO:0006268)3.97817194
14mitotic recombination (GO:0006312)3.94357396
15ribosomal small subunit biogenesis (GO:0042274)3.92756319
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.89332014
17L-serine metabolic process (GO:0006563)3.86171509
18cotranslational protein targeting to membrane (GO:0006613)3.77915651
19establishment of viral latency (GO:0019043)3.77617566
20protein targeting to ER (GO:0045047)3.76353792
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.70541649
22telomere maintenance via telomere lengthening (GO:0010833)3.69976925
23translational initiation (GO:0006413)3.62208364
24pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.56657543
25establishment of protein localization to mitochondrial membrane (GO:0090151)3.55854360
26protein localization to endoplasmic reticulum (GO:0070972)3.54277712
27establishment of protein localization to endoplasmic reticulum (GO:0072599)3.54016670
28ribosomal large subunit biogenesis (GO:0042273)3.53075717
29nucleotide-excision repair, DNA gap filling (GO:0006297)3.51625293
30DNA replication checkpoint (GO:0000076)3.50996456
31formation of translation preinitiation complex (GO:0001731)3.49691130
32regulation of mitochondrial translation (GO:0070129)3.49333476
33chaperone-mediated protein transport (GO:0072321)3.46498692
34viral life cycle (GO:0019058)3.46320703
35cellular protein complex disassembly (GO:0043624)3.45167029
36pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.42440742
37regulation of translational termination (GO:0006449)3.41784814
38kinetochore organization (GO:0051383)3.40888121
39nucleobase-containing small molecule interconversion (GO:0015949)3.38637103
40mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.37845137
41CENP-A containing nucleosome assembly (GO:0034080)3.36569916
42deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.35835082
43negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.34079504
44sister chromatid segregation (GO:0000819)3.33958539
45cellular component biogenesis (GO:0044085)3.30129293
46chromatin remodeling at centromere (GO:0031055)3.28514181
47regulation of translational fidelity (GO:0006450)3.27090741
48pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.22106089
49protein complex disassembly (GO:0043241)3.21128700
50anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.17883506
51negative regulation of RNA splicing (GO:0033119)3.13135728
52negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.12696122
53negative regulation of ligase activity (GO:0051352)3.12696122
54protein localization to kinetochore (GO:0034501)3.11879468
55kinetochore assembly (GO:0051382)3.11057562
56energy coupled proton transport, down electrochemical gradient (GO:0015985)3.10011712
57ATP synthesis coupled proton transport (GO:0015986)3.10011712
58regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.09860483
59protein targeting to membrane (GO:0006612)3.08433211
60nuclear-transcribed mRNA catabolic process (GO:0000956)3.07939098
61protein maturation by protein folding (GO:0022417)3.07653344
62pseudouridine synthesis (GO:0001522)3.07133081
63ribonucleoprotein complex biogenesis (GO:0022613)3.06786788
64negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.05524595
65DNA replication-independent nucleosome assembly (GO:0006336)3.04763040
66DNA replication-independent nucleosome organization (GO:0034724)3.04763040
67macromolecular complex disassembly (GO:0032984)3.01897883
68protein localization to chromosome, centromeric region (GO:0071459)2.97448962
69folic acid-containing compound biosynthetic process (GO:0009396)2.96824867
70positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.96406639
71pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.95186266
72pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.94932222
73mRNA catabolic process (GO:0006402)2.94351315
74telomere organization (GO:0032200)2.94030852
75deoxyribonucleotide biosynthetic process (GO:0009263)2.93647888
76nucleobase biosynthetic process (GO:0046112)2.93235395
77telomere maintenance (GO:0000723)2.93159308
78protein targeting to mitochondrion (GO:0006626)2.92900764
79meiotic chromosome segregation (GO:0045132)2.92038100
80deoxyribose phosphate biosynthetic process (GO:0046385)2.91933141
812-deoxyribonucleotide biosynthetic process (GO:0009265)2.91933141
82UTP biosynthetic process (GO:0006228)2.91723204
83mitotic nuclear envelope disassembly (GO:0007077)2.91414952
84RNA catabolic process (GO:0006401)2.90295557
85regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.89942802
86translation (GO:0006412)2.86753865
87serine family amino acid biosynthetic process (GO:0009070)2.85584520
88guanosine-containing compound biosynthetic process (GO:1901070)2.84374736
89chromatin assembly (GO:0031497)2.83264547
90spliceosomal snRNP assembly (GO:0000387)2.82844803
91viral mRNA export from host cell nucleus (GO:0046784)2.81587377
92termination of RNA polymerase II transcription (GO:0006369)2.81155956
93proteasome assembly (GO:0043248)2.80534412
94rRNA processing (GO:0006364)2.79132335
95exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.77542046
96histone exchange (GO:0043486)2.76483782
97transcription-coupled nucleotide-excision repair (GO:0006283)2.74794580
98mitotic metaphase plate congression (GO:0007080)2.73785268
99DNA replication-dependent nucleosome assembly (GO:0006335)2.73758898
100DNA replication-dependent nucleosome organization (GO:0034723)2.73758898
101IMP biosynthetic process (GO:0006188)2.73319861
102base-excision repair (GO:0006284)2.72425756
103DNA topological change (GO:0006265)2.72370951
104negative regulation of phagocytosis (GO:0050765)2.71604585
105rRNA metabolic process (GO:0016072)2.68690214
106translesion synthesis (GO:0019985)2.65077317
107nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.65021599
108maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.63377789
109membrane disassembly (GO:0030397)2.61717666
110nuclear envelope disassembly (GO:0051081)2.61717666
111establishment of integrated proviral latency (GO:0075713)2.61379526
112metaphase plate congression (GO:0051310)2.60762933
113mismatch repair (GO:0006298)2.60347785
114purine nucleobase biosynthetic process (GO:0009113)2.59330285
115negative regulation of mRNA processing (GO:0050686)2.59295286
116ribosome biogenesis (GO:0042254)2.59161214
117DNA duplex unwinding (GO:0032508)2.58802527
118DNA ligation (GO:0006266)2.57766406
119RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.56829451
120mRNA splicing, via spliceosome (GO:0000398)2.56829451
121RNA splicing, via transesterification reactions (GO:0000375)2.56646625
122DNA geometric change (GO:0032392)2.55645767
123spliceosomal complex assembly (GO:0000245)2.52548717
124IMP metabolic process (GO:0046040)2.51945685
125establishment of chromosome localization (GO:0051303)2.51180114
126regulation of double-strand break repair via homologous recombination (GO:0010569)2.50683397
127regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.49488581
128histone H2A acetylation (GO:0043968)2.48806266
129somatic hypermutation of immunoglobulin genes (GO:0016446)2.48363608
130somatic diversification of immune receptors via somatic mutation (GO:0002566)2.48363608
131ATP-dependent chromatin remodeling (GO:0043044)2.46403418
132mitotic chromosome condensation (GO:0007076)2.45197238
133DNA catabolic process, exonucleolytic (GO:0000738)2.44158984
134regulation of nuclear cell cycle DNA replication (GO:0033262)2.43499265
135chromatin assembly or disassembly (GO:0006333)2.43387344
136mitotic sister chromatid segregation (GO:0000070)2.42879047

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.93112462
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.72408701
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.63633699
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.41377505
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.29105769
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.96313764
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.67795865
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.62083444
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.58108178
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.58096215
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.51856777
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.44884609
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.43382413
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.43285864
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.39788741
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.38056191
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.33027931
18SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.27340137
19XRN2_22483619_ChIP-Seq_HELA_Human2.18954753
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.17222135
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.15547757
22* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.13046466
23TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.08934325
24MYC_22102868_ChIP-Seq_BL_Human2.08480799
25VDR_23849224_ChIP-Seq_CD4+_Human2.05644785
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.99409768
27FOXP3_21729870_ChIP-Seq_TREG_Human1.94722914
28* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94631476
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.85004927
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.84948180
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81887691
32E2F1_21310950_ChIP-Seq_MCF-7_Human1.80472590
33VDR_21846776_ChIP-Seq_THP-1_Human1.79712690
34DCP1A_22483619_ChIP-Seq_HELA_Human1.76371975
35CIITA_25753668_ChIP-Seq_RAJI_Human1.74355442
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.70935867
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67146453
38GABP_19822575_ChIP-Seq_HepG2_Human1.66649603
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.61852696
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.60476722
41TTF2_22483619_ChIP-Seq_HELA_Human1.59700499
42SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.59226133
43ERG_20887958_ChIP-Seq_HPC-7_Mouse1.57511940
44AR_21909140_ChIP-Seq_LNCAP_Human1.56681154
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.56254151
46IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.56157701
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54015953
48SCL_19346495_ChIP-Seq_HPC-7_Human1.51658017
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46711198
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.46069564
51SPI1_23547873_ChIP-Seq_NB4_Human1.45429270
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44625938
53PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43282678
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.42146712
55* SRF_21415370_ChIP-Seq_HL-1_Mouse1.41973148
56MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.39074817
57IRF8_22096565_ChIP-ChIP_GC-B_Human1.38900181
58* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.38009748
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37550945
60* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36964585
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36780914
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36494194
63* ELK1_19687146_ChIP-ChIP_HELA_Human1.35661623
64ZNF263_19887448_ChIP-Seq_K562_Human1.35236315
65KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.34293542
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.34275145
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33063971
68RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.31418956
69ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.29447329
70BP1_19119308_ChIP-ChIP_Hs578T_Human1.28123343
71YY1_21170310_ChIP-Seq_MESCs_Mouse1.27242505
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25966047
73TP63_19390658_ChIP-ChIP_HaCaT_Human1.24045668
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23447975
75GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.22813778
76KDM5A_27292631_Chip-Seq_BREAST_Human1.20057231
77MYB_21317192_ChIP-Seq_ERMYB_Mouse1.18339129
78PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.16291894
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14772079
80YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13194907
81CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12936208
82MAF_26560356_Chip-Seq_TH1_Human1.11998093
83CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09630170
84CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09450691
85STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08837039
86SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08655355
87UTX_26944678_Chip-Seq_JUKART_Human1.07568236
88MYB_26560356_Chip-Seq_TH2_Human1.07391297
89* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.07224818
90STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07048761
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06753891
92CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06582819
93GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06006537
94MYB_26560356_Chip-Seq_TH1_Human1.05927236
95CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05364696
96TET1_21451524_ChIP-Seq_MESCs_Mouse1.04184008
97DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04149384
98BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03213534
99OCT4_18692474_ChIP-Seq_MEFs_Mouse1.02274513
100RUNX1_22412390_ChIP-Seq_EML_Mouse1.01604398
101CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01207124
102VDR_24763502_ChIP-Seq_THP-1_Human1.00221929
103E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00209320
104* FOXP1_21924763_ChIP-Seq_HESCs_Human0.99955346
105SOX2_18692474_ChIP-Seq_MEFs_Mouse0.98117966
106TFEB_21752829_ChIP-Seq_HELA_Human0.96755213
107CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.95713421
108IRF8_21731497_ChIP-ChIP_J774_Mouse0.95556582
109* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95114003
110GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93802192
111* MAF_26560356_Chip-Seq_TH2_Human0.93732427
112CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93457811
113MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93380474
114DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93106331
115LXR_22292898_ChIP-Seq_THP-1_Human0.92141918
116TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91791943
117BRD4_27068464_Chip-Seq_AML-cells_Mouse0.90650587
118ELK3_25401928_ChIP-Seq_HUVEC_Human0.90072441
119NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.89604825
120MYC_18940864_ChIP-ChIP_HL60_Human0.89202965
121ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88543423
122HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88323119
123POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.87154644
124SOX2_18555785_ChIP-Seq_MESCs_Mouse0.85553959
125* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84012302
126CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83963940
127P68_20966046_ChIP-Seq_HELA_Human0.83629113
128SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82966969
129NANOG_21062744_ChIP-ChIP_HESCs_Human0.81715090

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.57821454
2MP0010094_abnormal_chromosome_stability3.47313148
3MP0002396_abnormal_hematopoietic_system3.43871836
4MP0008057_abnormal_DNA_replication3.16302417
5MP0003111_abnormal_nucleus_morphology3.04009763
6MP0003077_abnormal_cell_cycle2.97479642
7MP0004957_abnormal_blastocyst_morpholog2.89448450
8MP0008007_abnormal_cellular_replicative2.66158166
9MP0008058_abnormal_DNA_repair2.65233291
10MP0004808_abnormal_hematopoietic_stem2.22406334
11MP0003763_abnormal_thymus_physiology2.11377814
12MP0000490_abnormal_crypts_of2.10013473
13MP0001835_abnormal_antigen_presentation2.06607178
14MP0000685_abnormal_immune_system2.01120789
15MP0005397_hematopoietic_system_phenotyp2.00119562
16MP0001545_abnormal_hematopoietic_system2.00119562
17MP0006054_spinal_hemorrhage1.89324182
18MP0002163_abnormal_gland_morphology1.79757533
19MP0002398_abnormal_bone_marrow1.75756460
20MP0009333_abnormal_splenocyte_physiolog1.75537697
21MP0008932_abnormal_embryonic_tissue1.69123456
22MP0003315_abnormal_perineum_morphology1.66615735
23MP0003718_maternal_effect1.60391283
24MP0003786_premature_aging1.58943210
25MP0010352_gastrointestinal_tract_polyps1.58815715
26MP0009785_altered_susceptibility_to1.55519833
27MP0000350_abnormal_cell_proliferation1.55054186
28MP0002697_abnormal_eye_size1.54605279
29MP0000689_abnormal_spleen_morphology1.54521179
30MP0002722_abnormal_immune_system1.54480135
31MP0001800_abnormal_humoral_immune1.54281479
32MP0005671_abnormal_response_to1.53389585
33MP0002254_reproductive_system_inflammat1.48905103
34MP0002166_altered_tumor_susceptibility1.48148102
35MP0003436_decreased_susceptibility_to1.46166584
36MP0000703_abnormal_thymus_morphology1.45769541
37MP0002019_abnormal_tumor_incidence1.45422782
38MP0002132_abnormal_respiratory_system1.44484459
39MP0009672_abnormal_birth_weight1.41785045
40MP0002452_abnormal_antigen_presenting1.41213646
41MP0002420_abnormal_adaptive_immunity1.41018704
42MP0002429_abnormal_blood_cell1.40675591
43MP0001730_embryonic_growth_arrest1.40254661
44MP0003941_abnormal_skin_development1.39882793
45MP0000716_abnormal_immune_system1.39683537
46MP0005451_abnormal_body_composition1.38195159
47MP0001819_abnormal_immune_cell1.38190704
48MP0002006_tumorigenesis1.37692452
49MP0005174_abnormal_tail_pigmentation1.35499634
50MP0006035_abnormal_mitochondrial_morpho1.34135359
51MP0000858_altered_metastatic_potential1.31650682
52* MP0000313_abnormal_cell_death1.30923648
53* MP0005025_abnormal_response_to1.30052096
54MP0001853_heart_inflammation1.28108105
55MP0005075_abnormal_melanosome_morpholog1.26688871
56MP0000428_abnormal_craniofacial_morphol1.25216862
57MP0005501_abnormal_skin_physiology1.24918349
58MP0001346_abnormal_lacrimal_gland1.23506268
59MP0005000_abnormal_immune_tolerance1.23478249
60* MP0002723_abnormal_immune_serum1.23406538
61MP0009278_abnormal_bone_marrow1.19625245
62MP0010030_abnormal_orbit_morphology1.19434858
63MP0001849_ear_inflammation1.19434653
64MP0003567_abnormal_fetal_cardiomyocyte1.18846248
65MP0008877_abnormal_DNA_methylation1.17944906
66MP0005464_abnormal_platelet_physiology1.17864774
67MP0004185_abnormal_adipocyte_glucose1.16542525
68MP0002111_abnormal_tail_morphology1.16369743
69MP0000465_gastrointestinal_hemorrhage1.16294335
70MP0002405_respiratory_system_inflammati1.16093123
71MP0002148_abnormal_hypersensitivity_rea1.15097576
72MP0009379_abnormal_foot_pigmentation1.12122569
73MP0000358_abnormal_cell_content/1.11189410
74MP0010155_abnormal_intestine_physiology1.10812125
75MP0001697_abnormal_embryo_size1.10747532
76MP0001661_extended_life_span1.10445585
77MP0008789_abnormal_olfactory_epithelium1.09396769
78MP0003123_paternal_imprinting1.07323414
79MP0001873_stomach_inflammation1.06522851
80MP0002653_abnormal_ependyma_morphology1.05651158
81MP0004233_abnormal_muscle_weight1.05556358
82MP0002080_prenatal_lethality1.05006242
83MP0010307_abnormal_tumor_latency1.04663365
84MP0001672_abnormal_embryogenesis/_devel1.04620410
85MP0005380_embryogenesis_phenotype1.04620410
86MP0000537_abnormal_urethra_morphology1.03965286
87MP0003186_abnormal_redox_activity1.03355702
88MP0000049_abnormal_middle_ear1.02373886
89MP0002419_abnormal_innate_immunity1.01768090
90MP0002095_abnormal_skin_pigmentation1.01579153
91MP0001286_abnormal_eye_development1.01352426
92MP0003984_embryonic_growth_retardation0.98666938
93MP0002210_abnormal_sex_determination0.97185910
94MP0003937_abnormal_limbs/digits/tail_de0.96810192
95MP0002088_abnormal_embryonic_growth/wei0.95863848
96MP0001881_abnormal_mammary_gland0.94297743
97MP0000678_abnormal_parathyroid_gland0.93715468
98MP0005387_immune_system_phenotype0.93579028
99MP0001790_abnormal_immune_system0.93579028
100MP0004197_abnormal_fetal_growth/weight/0.92473976
101MP0003878_abnormal_ear_physiology0.91735523
102MP0005377_hearing/vestibular/ear_phenot0.91735523
103MP0009697_abnormal_copulation0.90116353
104MP0002086_abnormal_extraembryonic_tissu0.89118826
105MP0001929_abnormal_gametogenesis0.88314700
106MP0003705_abnormal_hypodermis_morpholog0.87201339
107MP0001293_anophthalmia0.86456446
108MP0003943_abnormal_hepatobiliary_system0.85366255
109MP0002085_abnormal_embryonic_tissue0.84945444
110MP0001727_abnormal_embryo_implantation0.84386640
111MP0001145_abnormal_male_reproductive0.83797284
112MP0002092_abnormal_eye_morphology0.83076897
113MP0002249_abnormal_larynx_morphology0.81892416
114MP0002796_impaired_skin_barrier0.81299415
115MP0003866_abnormal_defecation0.80935238
116MP0005394_taste/olfaction_phenotype0.80766924
117MP0005499_abnormal_olfactory_system0.80766924
118MP0001845_abnormal_inflammatory_respons0.78638273
119MP0004858_abnormal_nervous_system0.78375748
120MP0001915_intracranial_hemorrhage0.77869301
121MP0003806_abnormal_nucleotide_metabolis0.76975903
122MP0002877_abnormal_melanocyte_morpholog0.76739084
123MP0003942_abnormal_urinary_system0.75863502
124MP0005023_abnormal_wound_healing0.75827907
125MP0001119_abnormal_female_reproductive0.75631475
126MP0001919_abnormal_reproductive_system0.71326388
127MP0000653_abnormal_sex_gland0.71074937
128MP0003448_altered_tumor_morphology0.70711712
129MP0006292_abnormal_olfactory_placode0.70402067
130MP0000477_abnormal_intestine_morphology0.70377147
131MP0002233_abnormal_nose_morphology0.69673046
132MP0002160_abnormal_reproductive_system0.69373091
133MP0000566_synostosis0.68101424
134MP0006036_abnormal_mitochondrial_physio0.67860577
135MP0003861_abnormal_nervous_system0.67441375
136MP0000371_diluted_coat_color0.67205724
137MP0002009_preneoplasia0.66666054
138MP0003136_yellow_coat_color0.65935884
139MP0002084_abnormal_developmental_patter0.65294834
140MP0000750_abnormal_muscle_regeneration0.65188675
141MP0001529_abnormal_vocalization0.63611024
142MP0002075_abnormal_coat/hair_pigmentati0.63398053
143MP0005384_cellular_phenotype0.63228599
144MP0000015_abnormal_ear_pigmentation0.61200556
145MP0005076_abnormal_cell_differentiation0.61150982
146MP0009053_abnormal_anal_canal0.61111741
147MP0003938_abnormal_ear_development0.61097369
148MP0002938_white_spotting0.60809562
149MP0003699_abnormal_female_reproductive0.58438075
150MP0002161_abnormal_fertility/fecundity0.58277020
151MP0005379_endocrine/exocrine_gland_phen0.57666813
152MP0004147_increased_porphyrin_level0.57394531

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)5.10557283
2Abnormality of cells of the erythroid lineage (HP:0012130)5.09656661
3Reticulocytopenia (HP:0001896)4.63418841
4Aplastic anemia (HP:0001915)4.51740530
5Septo-optic dysplasia (HP:0100842)3.95266823
6Thrombocytosis (HP:0001894)3.82108281
7Abnormal mitochondria in muscle tissue (HP:0008316)3.56239019
8Acute necrotizing encephalopathy (HP:0006965)3.50026603
9Birth length less than 3rd percentile (HP:0003561)3.23291842
10Acute encephalopathy (HP:0006846)3.20411221
11Pallor (HP:0000980)3.06921943
12Colon cancer (HP:0003003)3.02907943
13Oral leukoplakia (HP:0002745)2.96774183
14Chromsome breakage (HP:0040012)2.93310013
15Selective tooth agenesis (HP:0001592)2.91123607
16Progressive muscle weakness (HP:0003323)2.89992060
17Macrocytic anemia (HP:0001972)2.83746763
1811 pairs of ribs (HP:0000878)2.79786673
19IgM deficiency (HP:0002850)2.76042068
20Maternal diabetes (HP:0009800)2.74351360
21Myelodysplasia (HP:0002863)2.70700225
22Aplasia/Hypoplasia of the sacrum (HP:0008517)2.66531279
23Chromosomal breakage induced by crosslinking agents (HP:0003221)2.64614710
24Petechiae (HP:0000967)2.63963545
25Duplication of thumb phalanx (HP:0009942)2.62206120
26Elevated erythrocyte sedimentation rate (HP:0003565)2.60341143
27Meckel diverticulum (HP:0002245)2.55382326
28Recurrent bronchitis (HP:0002837)2.55142942
29Abnormality of the ileum (HP:0001549)2.52698144
30Mitochondrial inheritance (HP:0001427)2.52526329
31Multiple enchondromatosis (HP:0005701)2.50549713
32Absent septum pellucidum (HP:0001331)2.49035970
33Partial duplication of thumb phalanx (HP:0009944)2.45109333
34Increased CSF lactate (HP:0002490)2.44578899
35Progressive macrocephaly (HP:0004481)2.42761817
36Cerebral edema (HP:0002181)2.41300621
37Abnormality of the anterior horn cell (HP:0006802)2.41025951
38Degeneration of anterior horn cells (HP:0002398)2.41025951
39Abnormality of the preputium (HP:0100587)2.39576338
40Bone marrow hypocellularity (HP:0005528)2.39344251
41Horseshoe kidney (HP:0000085)2.37925707
42Chronic otitis media (HP:0000389)2.37595855
43Breast hypoplasia (HP:0003187)2.37548365
44Premature graying of hair (HP:0002216)2.33722879
45Absent thumb (HP:0009777)2.33540024
46Hypoplastic pelvis (HP:0008839)2.33523764
47High anterior hairline (HP:0009890)2.31069254
48Exercise intolerance (HP:0003546)2.28559546
49Pancytopenia (HP:0001876)2.27623593
50Abnormality of cochlea (HP:0000375)2.27000484
51Microretrognathia (HP:0000308)2.25928843
52Rough bone trabeculation (HP:0100670)2.25543750
53Type I transferrin isoform profile (HP:0003642)2.24837066
54Abnormality of chromosome stability (HP:0003220)2.24464830
55Abnormality of glycolysis (HP:0004366)2.23547735
56Poikiloderma (HP:0001029)2.23362527
57Broad distal phalanx of finger (HP:0009836)2.23002498
58Abnormality of T cell physiology (HP:0011840)2.21740540
59Myositis (HP:0100614)2.21185441
60Hepatocellular necrosis (HP:0001404)2.20780331
61Patellar aplasia (HP:0006443)2.20263065
62Medulloblastoma (HP:0002885)2.18737036
63Abnormal gallbladder physiology (HP:0012438)2.17588702
64Cholecystitis (HP:0001082)2.17588702
65Aplasia/Hypoplasia of the uvula (HP:0010293)2.16865403
66Abnormality of DNA repair (HP:0003254)2.14859731
67Abnormality of the septum pellucidum (HP:0007375)2.14312863
68Ragged-red muscle fibers (HP:0003200)2.13133399
69Increased hepatocellular lipid droplets (HP:0006565)2.13079005
70Lymphoma (HP:0002665)2.12751749
71Increased serum lactate (HP:0002151)2.11953105
72Trismus (HP:0000211)2.11652435
73Cellulitis (HP:0100658)2.11300564
74Decreased activity of mitochondrial respiratory chain (HP:0008972)2.11059974
75Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.11059974
76Increased intramyocellular lipid droplets (HP:0012240)2.10311643
77Abnormality of the heme biosynthetic pathway (HP:0010472)2.09993299
78Small intestinal stenosis (HP:0012848)2.09763146
79Duodenal stenosis (HP:0100867)2.09763146
80Partial duplication of the phalanx of hand (HP:0009999)2.09453639
81Clubbing of toes (HP:0100760)2.08859262
82Aplasia/Hypoplasia of the patella (HP:0006498)2.08549656
83B lymphocytopenia (HP:0010976)2.07642874
84Abnormality of B cell number (HP:0010975)2.07642874
85Recurrent viral infections (HP:0004429)2.07388675
86Prolonged bleeding time (HP:0003010)2.06807300
87Amaurosis fugax (HP:0100576)2.05769246
88Basal cell carcinoma (HP:0002671)2.05375322
89Asplenia (HP:0001746)2.01223524
90Lipid accumulation in hepatocytes (HP:0006561)2.00536130
91Nasal polyposis (HP:0100582)2.00391895
92Cleft eyelid (HP:0000625)1.99595788
93Reduced antithrombin III activity (HP:0001976)1.98779469
94Impulsivity (HP:0100710)1.97908383
95Increased serum pyruvate (HP:0003542)1.97581800
96Abnormality of T cells (HP:0002843)1.96701436
97Respiratory difficulties (HP:0002880)1.95866950
98Muscle fiber atrophy (HP:0100295)1.95572063
99Squamous cell carcinoma (HP:0002860)1.94005877
100Recurrent abscess formation (HP:0002722)1.93668818
101Optic nerve coloboma (HP:0000588)1.93243166
102Short thumb (HP:0009778)1.91867043
103Hypoparathyroidism (HP:0000829)1.91792852
104Lactic acidosis (HP:0003128)1.91376185
105Abnormal number of incisors (HP:0011064)1.91126067
106Neoplasm of the pancreas (HP:0002894)1.90646764
107Acute myeloid leukemia (HP:0004808)1.90607718
108Increased muscle lipid content (HP:0009058)1.90564236
109Facial cleft (HP:0002006)1.90141291
110Increased nuchal translucency (HP:0010880)1.90056726
111Type 2 muscle fiber atrophy (HP:0003554)1.89722602
112Missing ribs (HP:0000921)1.89147972
113IgG deficiency (HP:0004315)1.89131418
114Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.88775247
115Hepatic necrosis (HP:0002605)1.88605642
116Abnormality of the carotid arteries (HP:0005344)1.88393986
117Tracheoesophageal fistula (HP:0002575)1.87946984
118Agnosia (HP:0010524)1.87943184
119Cellular immunodeficiency (HP:0005374)1.87309285
120Absent radius (HP:0003974)1.86160381
121Abnormal lung lobation (HP:0002101)1.85985066
122Supernumerary spleens (HP:0009799)1.83217288
123Atresia of the external auditory canal (HP:0000413)1.83011399
124Aplasia/Hypoplasia of the spleen (HP:0010451)1.82243430
125Progressive external ophthalmoplegia (HP:0000590)1.81443185
126Proximal placement of thumb (HP:0009623)1.81434784
127Preauricular skin tag (HP:0000384)1.80276143
128Carpal bone hypoplasia (HP:0001498)1.79825914
129Aplasia involving forearm bones (HP:0009822)1.79442750
130Absent forearm bone (HP:0003953)1.79442750
131Abnormality of the nasal mucosa (HP:0000433)1.78576708
132Down-sloping shoulders (HP:0200021)1.78459898
133Meningitis (HP:0001287)1.78002159
134Bronchitis (HP:0012387)1.75600217
135Hypergonadotropic hypogonadism (HP:0000815)1.73543027
136Triphalangeal thumb (HP:0001199)1.72489592
137Abnormality of the duodenum (HP:0002246)1.72413574
138Ectopic kidney (HP:0000086)1.71241059
139Abnormal protein glycosylation (HP:0012346)1.71154278
140Abnormal glycosylation (HP:0012345)1.71154278
141Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.71154278
142Abnormal protein N-linked glycosylation (HP:0012347)1.71154278
143Testicular atrophy (HP:0000029)1.70632679
144Acute lymphatic leukemia (HP:0006721)1.70248379
145Dysphonia (HP:0001618)1.70080043
146Sloping forehead (HP:0000340)1.70027228
147Microvesicular hepatic steatosis (HP:0001414)1.69953091
148Short middle phalanx of the 5th finger (HP:0004220)1.69414011
149High pitched voice (HP:0001620)1.69249004
150Abnormality of reticulocytes (HP:0004312)1.68992968
151Abnormality of cells of the lymphoid lineage (HP:0012140)1.68425440
152Leukodystrophy (HP:0002415)1.67052565
153Abnormal trabecular bone morphology (HP:0100671)1.66619057
154Mediastinal lymphadenopathy (HP:0100721)1.66478803
155Epistaxis (HP:0000421)1.66190366
156Gout (HP:0001997)1.66108640
157Agammaglobulinemia (HP:0004432)1.65814860
158Leukopenia (HP:0001882)1.65188364
159Bicuspid aortic valve (HP:0001647)1.64921074
160Granulocytopenia (HP:0001913)1.64895348

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.30426539
2WEE13.43648491
3BUB13.38391638
4CDC73.09870659
5SMG12.83872760
6NME22.82836673
7MAP4K12.67830160
8MAP3K102.59290018
9PBK2.30795014
10STK162.28202427
11SRPK12.16400858
12NEK22.15093634
13PASK2.06135714
14EIF2AK12.01040432
15ACVR1B1.93921109
16TLK11.87454867
17BRSK21.85854642
18MKNK11.80230048
19EEF2K1.77994654
20CDK191.77089146
21TAF11.74364435
22EIF2AK31.62836989
23NME11.62016294
24CDK71.61994245
25TGFBR11.59612817
26TESK21.56421673
27VRK11.54508123
28BTK1.52151029
29RPS6KA41.47175806
30PIM21.46000005
31ARAF1.45303441
32ATR1.43360595
33KIT1.42178771
34FLT31.41031211
35DYRK31.40438212
36PLK41.40121285
37BRAF1.39079499
38RPS6KB21.35868337
39STK101.35206563
40PLK11.26681020
41PIM11.26328331
42CDK41.25116515
43PAK41.24960472
44STK41.24150722
45MAP2K31.23860953
46AURKB1.23368177
47KDR1.23100771
48MAP3K91.20211800
49IRAK41.19254744
50TESK11.15392573
51BRSK11.14777882
52TEC1.14567311
53TXK1.08663711
54MKNK21.08122164
55TTK1.05807538
56EPHA21.05304035
57CSF1R0.99932176
58LRRK20.99501414
59CDK80.96920719
60TYK20.93940496
61JAK30.92254872
62TBK10.91724107
63CLK10.91534818
64ZAK0.90830898
65ZAP700.90441720
66MAP3K110.90422468
67MAP3K80.89704561
68IKBKB0.86500801
69CHEK20.82979892
70BCKDK0.82549423
71BLK0.81890822
72TSSK60.79192028
73IKBKE0.76919568
74ERN10.76657063
75SIK30.76107391
76TRIB30.74455603
77GRK60.73333565
78EIF2AK20.69637256
79CHEK10.69298269
80DAPK10.69272175
81AURKA0.68307376
82PKN20.68240250
83SYK0.65692158
84MST40.65670979
85CHUK0.64902627
86CCNB10.64213301
87NLK0.61750072
88LYN0.61478639
89AKT20.60907361
90CDK60.60615737
91MAPKAPK30.60123959
92CDK10.59864791
93ICK0.59240668
94ABL20.58874268
95CSNK2A10.58656088
96ILK0.57441304
97BMX0.57075244
98DYRK20.55854208
99DAPK30.54995798
100ATM0.53755015
101MAP3K140.53243164
102SIK10.53094693
103PRKCI0.52892088
104TAOK20.51237777
105CDK20.50572989
106CDK120.49759935
107TYRO30.49102046
108LIMK10.48727965
109MATK0.48650217
110CSNK2A20.47758484
111MAPK110.47397743
112PLK30.47245775
113MAP2K20.45199952
114MAPKAPK20.44576530
115TGFBR20.44269162
116LCK0.43539761
117CDK11A0.42307330
118MTOR0.42053341
119CDK90.41673560
120SCYL20.40812813
121PAK10.40534416
122NEK90.40476374
123NEK10.40109061
124FGFR40.39980778
125PDK20.39329524
126IRAK30.38487205
127DMPK0.38477302
128MAP2K60.37285873
129ALK0.37175233
130DYRK1B0.36716007
131MYLK0.36313744
132CDK140.35419244
133RPS6KA10.35365744
134CAMK1D0.32475731
135CDK150.32158625
136NUAK10.28289410
137CSNK1E0.28194661
138PRKDC0.27360530
139CDK180.26950390

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.06701945
2Ribosome_Homo sapiens_hsa030104.07129686
3Mismatch repair_Homo sapiens_hsa034303.98687643
4Base excision repair_Homo sapiens_hsa034103.36122191
5Spliceosome_Homo sapiens_hsa030402.96730620
6Homologous recombination_Homo sapiens_hsa034402.90395192
7Nucleotide excision repair_Homo sapiens_hsa034202.57191283
8Proteasome_Homo sapiens_hsa030502.53578742
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.51188731
10RNA polymerase_Homo sapiens_hsa030202.35432347
11Pyrimidine metabolism_Homo sapiens_hsa002402.33378633
12RNA transport_Homo sapiens_hsa030132.20798619
13Cell cycle_Homo sapiens_hsa041102.20796154
14Fanconi anemia pathway_Homo sapiens_hsa034602.07608321
15One carbon pool by folate_Homo sapiens_hsa006701.98509123
16Oxidative phosphorylation_Homo sapiens_hsa001901.94780155
17Non-homologous end-joining_Homo sapiens_hsa034501.92592977
18RNA degradation_Homo sapiens_hsa030181.75530087
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.67031252
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.62881570
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.61393173
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.53238200
23Basal transcription factors_Homo sapiens_hsa030221.51978155
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.50468047
25p53 signaling pathway_Homo sapiens_hsa041151.49232281
26Primary immunodeficiency_Homo sapiens_hsa053401.42512124
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.35208202
28Herpes simplex infection_Homo sapiens_hsa051681.35178953
29Vitamin B6 metabolism_Homo sapiens_hsa007501.33327696
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.28872199
31mRNA surveillance pathway_Homo sapiens_hsa030151.26719581
32Antigen processing and presentation_Homo sapiens_hsa046121.13173155
33Pyruvate metabolism_Homo sapiens_hsa006201.12985037
34Purine metabolism_Homo sapiens_hsa002301.11899345
35Fatty acid elongation_Homo sapiens_hsa000621.10721806
36Alzheimers disease_Homo sapiens_hsa050101.08025564
37Systemic lupus erythematosus_Homo sapiens_hsa053221.04503685
38Epstein-Barr virus infection_Homo sapiens_hsa051691.02730265
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02353435
40Pentose phosphate pathway_Homo sapiens_hsa000301.01244157
41Measles_Homo sapiens_hsa051621.01137692
42Sulfur relay system_Homo sapiens_hsa041220.98730046
43Intestinal immune network for IgA production_Homo sapiens_hsa046720.96744522
44Legionellosis_Homo sapiens_hsa051340.95872706
45Leishmaniasis_Homo sapiens_hsa051400.95311010
46Selenocompound metabolism_Homo sapiens_hsa004500.92639576
47NF-kappa B signaling pathway_Homo sapiens_hsa040640.88210537
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84717461
49Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82961770
50Protein export_Homo sapiens_hsa030600.79553393
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78771867
52Viral carcinogenesis_Homo sapiens_hsa052030.78696563
53Hematopoietic cell lineage_Homo sapiens_hsa046400.78253914
54HTLV-I infection_Homo sapiens_hsa051660.77771633
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.74009647
56Bladder cancer_Homo sapiens_hsa052190.73993838
57Small cell lung cancer_Homo sapiens_hsa052220.72358005
58Folate biosynthesis_Homo sapiens_hsa007900.71110394
59B cell receptor signaling pathway_Homo sapiens_hsa046620.70910467
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.69993960
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.68760657
62N-Glycan biosynthesis_Homo sapiens_hsa005100.68517255
63Cardiac muscle contraction_Homo sapiens_hsa042600.67809131
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65051849
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64391033
66Notch signaling pathway_Homo sapiens_hsa043300.64272799
67Glutathione metabolism_Homo sapiens_hsa004800.62593535
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.62090678
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61939914
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61470684
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60578407
72Apoptosis_Homo sapiens_hsa042100.59653193
73Acute myeloid leukemia_Homo sapiens_hsa052210.59240815
74Steroid biosynthesis_Homo sapiens_hsa001000.59148982
75Fructose and mannose metabolism_Homo sapiens_hsa000510.57953177
76Hepatitis B_Homo sapiens_hsa051610.57833579
77Shigellosis_Homo sapiens_hsa051310.57491567
78Metabolic pathways_Homo sapiens_hsa011000.56388666
79Influenza A_Homo sapiens_hsa051640.55090281
80Huntingtons disease_Homo sapiens_hsa050160.54015796
81Allograft rejection_Homo sapiens_hsa053300.53227798
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53207028
83Biosynthesis of amino acids_Homo sapiens_hsa012300.51176195
84Arginine and proline metabolism_Homo sapiens_hsa003300.50553926
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.47875518
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47612027
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.44368041
88Thyroid cancer_Homo sapiens_hsa052160.43752769
89MicroRNAs in cancer_Homo sapiens_hsa052060.43249148
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42361739
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42190705
92Viral myocarditis_Homo sapiens_hsa054160.40998795
93Chronic myeloid leukemia_Homo sapiens_hsa052200.39916467
94Parkinsons disease_Homo sapiens_hsa050120.39731320
95Toxoplasmosis_Homo sapiens_hsa051450.38816888
96Lysine degradation_Homo sapiens_hsa003100.37219720
97Malaria_Homo sapiens_hsa051440.36838464
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35253838
99Carbon metabolism_Homo sapiens_hsa012000.34750476
100Renin-angiotensin system_Homo sapiens_hsa046140.34325801
101Toll-like receptor signaling pathway_Homo sapiens_hsa046200.33819024
102Hippo signaling pathway_Homo sapiens_hsa043900.32276140
103Graft-versus-host disease_Homo sapiens_hsa053320.32000691
104Asthma_Homo sapiens_hsa053100.31955609
105Galactose metabolism_Homo sapiens_hsa000520.31846650
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31443282
107Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31355753
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31285900
109Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31080695
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30770566
111Phenylalanine metabolism_Homo sapiens_hsa003600.30662582
112Osteoclast differentiation_Homo sapiens_hsa043800.30030573
113Basal cell carcinoma_Homo sapiens_hsa052170.28483814
114Pertussis_Homo sapiens_hsa051330.27891726
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27434016
116Wnt signaling pathway_Homo sapiens_hsa043100.27408081
117Caffeine metabolism_Homo sapiens_hsa002320.26549812
118Oocyte meiosis_Homo sapiens_hsa041140.25981148
119Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.25578040
120Arachidonic acid metabolism_Homo sapiens_hsa005900.24923068
121Leukocyte transendothelial migration_Homo sapiens_hsa046700.24798158
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24022016
123Hedgehog signaling pathway_Homo sapiens_hsa043400.22616607
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.22501930
125Other glycan degradation_Homo sapiens_hsa005110.21532101
126T cell receptor signaling pathway_Homo sapiens_hsa046600.20926957
127Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.20799894
128Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.20666026
129Pathways in cancer_Homo sapiens_hsa052000.20313704
130Arginine biosynthesis_Homo sapiens_hsa002200.18873349
131Fatty acid metabolism_Homo sapiens_hsa012120.17246928
132Propanoate metabolism_Homo sapiens_hsa006400.14340710
133Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.14339614
134Non-small cell lung cancer_Homo sapiens_hsa052230.10744540
135Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.10536531
136Tyrosine metabolism_Homo sapiens_hsa003500.10279011
137Pancreatic cancer_Homo sapiens_hsa052120.09950489

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