BCL2L13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrially-localized protein with conserved B-cell lymphoma 2 homology motifs. Overexpression of the encoded protein results in apoptosis. Alternatively spliced transcript variants have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular basement membrane development (GO:0032836)5.65020335
2skeletal muscle adaptation (GO:0043501)4.94575181
3actin-myosin filament sliding (GO:0033275)4.92386601
4muscle filament sliding (GO:0030049)4.92386601
5regulation of activation of Janus kinase activity (GO:0010533)4.91485059
6carnitine shuttle (GO:0006853)4.88033951
7positive regulation of phosphoprotein phosphatase activity (GO:0032516)4.82374355
8negative regulation of mast cell activation (GO:0033004)4.77750693
9lysine metabolic process (GO:0006553)4.74121002
10lysine catabolic process (GO:0006554)4.74121002
11fatty acid transmembrane transport (GO:1902001)4.63246767
12positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr4.63135935
13negative regulation of phagocytosis (GO:0050765)4.58028831
14regulation of sequestering of triglyceride (GO:0010889)4.52638757
152-oxoglutarate metabolic process (GO:0006103)4.31593574
16tricarboxylic acid cycle (GO:0006099)4.21399318
17positive regulation of fatty acid beta-oxidation (GO:0032000)4.19651115
18actin-mediated cell contraction (GO:0070252)4.04271537
19creatine metabolic process (GO:0006600)4.01468653
20peptidyl-proline hydroxylation (GO:0019511)3.99836741
21response to inactivity (GO:0014854)3.99654812
22regulation of fatty acid beta-oxidation (GO:0031998)3.97817785
23regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.96304462
24valine metabolic process (GO:0006573)3.96231747
25alpha-linolenic acid metabolic process (GO:0036109)3.92401201
26glycine metabolic process (GO:0006544)3.85352310
27pre-miRNA processing (GO:0031054)3.80762162
28regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.80717004
29protein hydroxylation (GO:0018126)3.80185887
30regulation of fatty acid oxidation (GO:0046320)3.77903696
31regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.76008851
32NADH metabolic process (GO:0006734)3.73880270
33mesenchymal-epithelial cell signaling (GO:0060638)3.73204976
34carnitine transmembrane transport (GO:1902603)3.72060647
35positive regulation of fatty acid oxidation (GO:0046321)3.64001449
36fatty acid beta-oxidation (GO:0006635)3.63557137
37sarcoplasmic reticulum calcium ion transport (GO:0070296)3.62853151
38amino-acid betaine metabolic process (GO:0006577)3.58780944
39muscle cell fate commitment (GO:0042693)3.57252736
40biotin metabolic process (GO:0006768)3.57148668
41negative regulation of fatty acid biosynthetic process (GO:0045717)3.55339665
42cellular response to epinephrine stimulus (GO:0071872)3.54901425
43myelination in peripheral nervous system (GO:0022011)3.54280241
44peripheral nervous system axon ensheathment (GO:0032292)3.54280241
45positive regulation of adherens junction organization (GO:1903393)3.52276076
46serine family amino acid catabolic process (GO:0009071)3.50948466
47carnitine transport (GO:0015879)3.47307932
48amino-acid betaine transport (GO:0015838)3.47307932
49tricarboxylic acid metabolic process (GO:0072350)3.46220653
50skeletal muscle contraction (GO:0003009)3.44679302
51fatty acid homeostasis (GO:0055089)3.42246637
52protoporphyrinogen IX metabolic process (GO:0046501)3.37489863
53negative regulation of stress fiber assembly (GO:0051497)3.37489327
54negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.36020197
55striated muscle hypertrophy (GO:0014897)3.34192350
56actin filament-based movement (GO:0030048)3.33478070
57fatty acid oxidation (GO:0019395)3.28615552
58response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.28394193
59carnitine metabolic process (GO:0009437)3.26713578
60striated muscle contraction (GO:0006941)3.22030338
61low-density lipoprotein particle clearance (GO:0034383)3.21811349
62negative regulation of potassium ion transmembrane transport (GO:1901380)3.19879135
63myofibril assembly (GO:0030239)3.19699111
64lipid oxidation (GO:0034440)3.19083132
65aspartate family amino acid catabolic process (GO:0009068)3.18134178
66acetyl-CoA metabolic process (GO:0006084)3.17151168
67oxaloacetate metabolic process (GO:0006107)3.17088246
68response to epinephrine (GO:0071871)3.17037230
69fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.15940792
70negative regulation of cell size (GO:0045792)3.15152164
71regulation of acyl-CoA biosynthetic process (GO:0050812)3.14674896
72proline transport (GO:0015824)3.14463594
73formation of translation preinitiation complex (GO:0001731)3.12526511
74regulation of early endosome to late endosome transport (GO:2000641)3.10992513
75regulation of triglyceride catabolic process (GO:0010896)3.08249866
76regulation of cofactor metabolic process (GO:0051193)3.06187093
77regulation of coenzyme metabolic process (GO:0051196)3.06187093
78succinate metabolic process (GO:0006105)3.06130413
79regulation of cholesterol homeostasis (GO:2000188)3.04160559
80regulation of translational fidelity (GO:0006450)3.01414663
81camera-type eye morphogenesis (GO:0048593)3.01382588
82cardiac muscle contraction (GO:0060048)3.00627053
83negative regulation of fatty acid metabolic process (GO:0045922)3.00118047
84positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.98980031
85folic acid metabolic process (GO:0046655)2.97247580
86protein localization to kinetochore (GO:0034501)2.96263402
87fatty acid catabolic process (GO:0009062)2.95351953
88regulation of translational termination (GO:0006449)2.95141160
89regulation of cholesterol storage (GO:0010885)2.94058250
90protoporphyrinogen IX biosynthetic process (GO:0006782)2.93778333
91positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.92429797
92short-chain fatty acid metabolic process (GO:0046459)2.91720607
93regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.90988846
94triglyceride catabolic process (GO:0019433)2.90752914
95embryonic camera-type eye development (GO:0031076)2.89879845
96positive regulation of lipid catabolic process (GO:0050996)2.89268827
97serine family amino acid metabolic process (GO:0009069)2.89020918
98positive regulation of steroid biosynthetic process (GO:0010893)2.87903431
99muscle hypertrophy (GO:0014896)2.87554936
100triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.86803862
101actomyosin structure organization (GO:0031032)2.86068188
1024-hydroxyproline metabolic process (GO:0019471)2.86026625
103sarcomere organization (GO:0045214)2.84416312
104porphyrin-containing compound biosynthetic process (GO:0006779)2.83087952
105positive regulation of focal adhesion assembly (GO:0051894)2.82672124
106positive regulation of cell junction assembly (GO:1901890)2.82672124
107Golgi transport vesicle coating (GO:0048200)2.82464925
108COPI coating of Golgi vesicle (GO:0048205)2.82464925
109glucan biosynthetic process (GO:0009250)2.82358961
110glycogen biosynthetic process (GO:0005978)2.82358961
111regulation of execution phase of apoptosis (GO:1900117)2.82322810
112regulation of spindle organization (GO:0090224)2.82225873
113mitochondrial DNA metabolic process (GO:0032042)2.80888100
114positive regulation of lipid storage (GO:0010884)2.79907614
115regulation of membrane protein ectodomain proteolysis (GO:0051043)2.79816982
116folic acid-containing compound biosynthetic process (GO:0009396)2.78983357
117positive regulation of histone deacetylation (GO:0031065)2.76428336
118response to hepatocyte growth factor (GO:0035728)2.76153555
119cellular response to hepatocyte growth factor stimulus (GO:0035729)2.76153555
120positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)2.75877717
121regulation of glucose import in response to insulin stimulus (GO:2001273)2.75638602
122positive regulation of triglyceride metabolic process (GO:0090208)2.75491370
123mitotic nuclear envelope disassembly (GO:0007077)2.74743605
124lipid particle organization (GO:0034389)2.73236844
125cardiac myofibril assembly (GO:0055003)2.72586152
126branched-chain amino acid metabolic process (GO:0009081)2.72268368
127neutral lipid catabolic process (GO:0046461)2.71630845
128acylglycerol catabolic process (GO:0046464)2.71630845
129plasma membrane repair (GO:0001778)2.70412129
130membrane raft organization (GO:0031579)2.70145855
131nuclear pore organization (GO:0006999)2.69724627
132cysteine metabolic process (GO:0006534)2.69649019
133maternal placenta development (GO:0001893)2.67705049
134negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.66949576
135regulation of relaxation of muscle (GO:1901077)2.66742536
136branched-chain amino acid catabolic process (GO:0009083)2.66407501
137mitotic G1 DNA damage checkpoint (GO:0031571)2.65562461
138regulation of mitotic spindle organization (GO:0060236)2.65506008
139protein localization to chromosome, centromeric region (GO:0071459)2.65376316
140positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.65193070
141import into cell (GO:0098657)2.64889254
142peptidyl-lysine dimethylation (GO:0018027)2.64848829
143striated muscle adaptation (GO:0014888)2.64365177
144positive regulation of triglyceride biosynthetic process (GO:0010867)2.63884835
145protein localization to cell surface (GO:0034394)2.62951035
146nuclear envelope disassembly (GO:0051081)2.62778885
147membrane disassembly (GO:0030397)2.62778885
148regulation of fatty acid metabolic process (GO:0019217)2.62660027
149monoubiquitinated protein deubiquitination (GO:0035520)2.62531554
150intracellular lipid transport (GO:0032365)2.62372385
151DNA unwinding involved in DNA replication (GO:0006268)2.61675617
152negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.60720892
153mitotic metaphase plate congression (GO:0007080)2.60532785
154mitotic chromosome condensation (GO:0007076)2.59917102
155macroautophagy (GO:0016236)2.58658643
156maturation of 5.8S rRNA (GO:0000460)2.58518426
157response to mercury ion (GO:0046689)2.56422056
158positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.54623584
159monocarboxylic acid catabolic process (GO:0072329)2.53508899
160one-carbon metabolic process (GO:0006730)2.52749060
161quaternary ammonium group transport (GO:0015697)2.52562472
162regulation of sulfur metabolic process (GO:0042762)2.52382224
163serine family amino acid biosynthetic process (GO:0009070)2.52378333
164keratan sulfate catabolic process (GO:0042340)2.52136227
165cellular response to prostaglandin stimulus (GO:0071379)2.51489508
166regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.51025846
167acylglycerol homeostasis (GO:0055090)2.50967731
168triglyceride homeostasis (GO:0070328)2.50967731
169dicarboxylic acid biosynthetic process (GO:0043650)2.49927411
170tetrapyrrole biosynthetic process (GO:0033014)2.49871629
171pentose-phosphate shunt (GO:0006098)2.49423036
172skeletal muscle fiber development (GO:0048741)2.48896572
173kynurenine metabolic process (GO:0070189)2.48593877
174positive regulation of Rap GTPase activity (GO:0032854)2.47906044
175positive regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045737)2.47629766
176linoleic acid metabolic process (GO:0043651)2.47161579
177response to muscle activity (GO:0014850)2.43134787
178growth hormone receptor signaling pathway (GO:0060396)2.42699828
179cellular response to growth hormone stimulus (GO:0071378)2.37376300
180primary alcohol catabolic process (GO:0034310)2.37198955
181glycolytic process (GO:0006096)2.36504749
182muscle contraction (GO:0006936)2.35129711
183induction of positive chemotaxis (GO:0050930)2.32880772

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.41732736
2* PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.08595981
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.50669975
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.16028042
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.58188901
6* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.96415694
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.95469153
8RXR_22158963_ChIP-Seq_LIVER_Mouse2.90173797
9* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.89205483
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.73715165
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.72637477
12RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.70545050
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.66762718
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.65594210
15MYC_22102868_ChIP-Seq_BL_Human2.58210538
16ZNF263_19887448_ChIP-Seq_K562_Human2.51721424
17ESR1_15608294_ChIP-ChIP_MCF-7_Human2.46476483
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.40941726
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.33577657
20TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.29847683
21SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.24133397
22CLOCK_20551151_ChIP-Seq_293T_Human2.22243287
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.20022210
24HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.18585936
25LXR_22158963_ChIP-Seq_LIVER_Mouse2.17171871
26SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.11926813
27SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.11926813
28SMAD_19615063_ChIP-ChIP_OVARY_Human2.11459322
29E2F4_17652178_ChIP-ChIP_JURKAT_Human2.09102882
30TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07768728
31RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.04037003
32AR_21909140_ChIP-Seq_LNCAP_Human1.99932072
33CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.98040145
34MYC_18555785_ChIP-Seq_MESCs_Mouse1.97357016
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.96080177
36EP300_21415370_ChIP-Seq_HL-1_Mouse1.94967515
37MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.91125533
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86974937
39* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.74999099
40PPAR_26484153_Chip-Seq_NCI-H1993_Human1.74253503
41BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.73455347
42SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.70391717
43PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.55181235
44JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.54041661
45NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.53433040
46FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.52622761
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.50756837
48WT1_19549856_ChIP-ChIP_CCG9911_Human1.50284157
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.49854428
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49655103
51ATF3_27146783_Chip-Seq_COLON_Human1.48913106
52VDR_21846776_ChIP-Seq_THP-1_Human1.44120340
53STAT3_1855785_ChIP-Seq_MESCs_Mouse1.43287132
54SOX9_24532713_ChIP-Seq_HFSC_Mouse1.43266077
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.43211610
56TCF7_22412390_ChIP-Seq_EML_Mouse1.43071816
57KLF4_18555785_ChIP-Seq_MESCs_Mouse1.42712206
58SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.40295504
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.38686416
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38657615
61* CIITA_25753668_ChIP-Seq_RAJI_Human1.38622912
62DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38109916
63NELFA_20434984_ChIP-Seq_ESCs_Mouse1.37188595
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.37110364
65SALL4_18804426_ChIP-ChIP_XEN_Mouse1.36942527
66KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.35482837
67CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.35284388
68MYC_19030024_ChIP-ChIP_MESCs_Mouse1.35115495
69KDM2B_26808549_Chip-Seq_DND41_Human1.34499086
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32579790
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.32056295
72KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31478147
73MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31373729
74ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29871136
75* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.29075288
76CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28617757
77* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.26836977
78EGR1_19032775_ChIP-ChIP_M12_Human1.26501382
79FOXO3_23340844_ChIP-Seq_DLD1_Human1.26486825
80* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.25322201
81ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.22960758
82GATA2_19941826_ChIP-Seq_K562_Human1.22312225
83RARG_19884340_ChIP-ChIP_MEFs_Mouse1.22275780
84XRN2_22483619_ChIP-Seq_HELA_Human1.21254082
85KDM5A_27292631_Chip-Seq_BREAST_Human1.20016077
86JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18698999
87NANOG_21062744_ChIP-ChIP_HESCs_Human1.17726209
88FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.16952757
89NFIB_24661679_ChIP-Seq_LUNG_Mouse1.16852862
90MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.14343243
91PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14241989
92SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.13653403
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13255692
94GATA1_22025678_ChIP-Seq_K562_Human1.12705090
95* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.12699882
96NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12566149
97UBF1/2_26484160_Chip-Seq_HMECs_Human1.11663568
98RACK7_27058665_Chip-Seq_MCF-7_Human1.11309774
99ESR1_20079471_ChIP-ChIP_T-47D_Human1.10930886
100EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10772287
101ESR1_21235772_ChIP-Seq_MCF-7_Human1.10757063
102CREB1_15753290_ChIP-ChIP_HEK293T_Human1.10738866
103FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.10164140
104TP53_23651856_ChIP-Seq_MEFs_Mouse1.08290099
105NCOR1_26117541_ChIP-Seq_K562_Human1.07514987
106STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.07464398
107CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06861290
108P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06643548
109TET1_21490601_ChIP-Seq_MESCs_Mouse1.06432704
110NANOG_18555785_ChIP-Seq_MESCs_Mouse1.06374052
111CJUN_26792858_Chip-Seq_BT549_Human1.05951343
112ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05765279
113* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05452575
114STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05362786
115ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03850186
116Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03798893
117* TBX20_22080862_ChIP-Seq_HEART_Mouse1.02346919
118* TBX20_22328084_ChIP-Seq_HEART_Mouse1.02346919
119GATA4_21415370_ChIP-Seq_HL-1_Mouse1.02341479
120HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01444088
121MAF_26560356_Chip-Seq_TH1_Human1.01265781
122NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01241829
123TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01224062
124P68_20966046_ChIP-Seq_HELA_Human1.00881031
125NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.00800085
126FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.99163259
127GATA1_19941826_ChIP-Seq_K562_Human0.99160260
128KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99150874
129CHD1_26751641_Chip-Seq_LNCaP_Human0.99113741
130NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98992884
131* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98365876
132KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98198294
133CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97539797
134POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.97384883
135HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96481163
136GABP_19822575_ChIP-Seq_HepG2_Human0.95602269
137TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.95207069
138UTX_26944678_Chip-Seq_JUKART_Human0.95100522
139LXR_22292898_ChIP-Seq_THP-1_Human0.94656294
140BRD4_27068464_Chip-Seq_AML-cells_Mouse0.94509199
141TBX5_21415370_ChIP-Seq_HL-1_Mouse0.92032112
142GATA6_25053715_ChIP-Seq_YYC3_Human0.91651036
143* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91106980
144TFEB_21752829_ChIP-Seq_HELA_Human0.90827773
145ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90617938
146RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.90601149
147* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.89638565
148TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.89326981
149CREB1_26743006_Chip-Seq_LNCaP_Human0.89255357
150ZNF217_24962896_ChIP-Seq_MCF-7_Human0.88126663
151* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87530475
152ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.86743243
153STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.86454320
154CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.86037749
155* GATA1_19941827_ChIP-Seq_MEL_Mouse0.85487037
156E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85481273
157EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.85293114
158KDM2B_26808549_Chip-Seq_K562_Human0.85086199
159KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.84869086

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.35355331
2MP0002139_abnormal_hepatobiliary_system3.23141306
3MP0008438_abnormal_cutaneous_collagen3.09188125
4MP0005257_abnormal_intraocular_pressure3.04548260
5MP0002332_abnormal_exercise_endurance3.00178992
6MP0005670_abnormal_white_adipose2.99830478
7MP0003646_muscle_fatigue2.99228484
8MP0004130_abnormal_muscle_cell2.96711447
9MP0005451_abnormal_body_composition2.78788862
10MP0005666_abnormal_adipose_tissue2.67399769
11MP0005365_abnormal_bile_salt2.65752159
12MP0002837_dystrophic_cardiac_calcinosis2.57844687
13MP0004185_abnormal_adipocyte_glucose2.53836170
14MP0005360_urolithiasis2.38295924
15MP0005085_abnormal_gallbladder_physiolo2.34513757
16MP0004272_abnormal_basement_membrane2.34486855
17MP0005377_hearing/vestibular/ear_phenot2.16570979
18MP0003878_abnormal_ear_physiology2.16570979
19MP0004084_abnormal_cardiac_muscle2.11923650
20MP0010329_abnormal_lipoprotein_level2.01056437
21MP0003111_abnormal_nucleus_morphology1.98870238
22MP0003656_abnormal_erythrocyte_physiolo1.89679120
23MP0009840_abnormal_foam_cell1.88371225
24MP0010352_gastrointestinal_tract_polyps1.85147682
25MP0004087_abnormal_muscle_fiber1.80811999
26MP0005375_adipose_tissue_phenotype1.76935929
27MP0005083_abnormal_biliary_tract1.76400481
28MP0002269_muscular_atrophy1.75723828
29MP0005330_cardiomyopathy1.75096977
30MP0003221_abnormal_cardiomyocyte_apopto1.70534952
31MP0005248_abnormal_Harderian_gland1.67449087
32MP0010630_abnormal_cardiac_muscle1.66408563
33MP0004145_abnormal_muscle_electrophysio1.66252555
34MP0002102_abnormal_ear_morphology1.64293054
35MP0010307_abnormal_tumor_latency1.63086761
36MP0000749_muscle_degeneration1.62097874
37MP0003252_abnormal_bile_duct1.61920104
38MP0000751_myopathy1.60655400
39MP0005076_abnormal_cell_differentiation1.58594565
40MP0004215_abnormal_myocardial_fiber1.58287313
41MP0005503_abnormal_tendon_morphology1.57658325
42MP0000750_abnormal_muscle_regeneration1.54393165
43MP0003693_abnormal_embryo_hatching1.52563105
44MP0000609_abnormal_liver_physiology1.52252855
45MP0002971_abnormal_brown_adipose1.51673270
46MP0010094_abnormal_chromosome_stability1.50881339
47MP0000747_muscle_weakness1.50451412
48MP0003950_abnormal_plasma_membrane1.49463038
49MP0003077_abnormal_cell_cycle1.48801334
50MP0001730_embryonic_growth_arrest1.47090110
51MP0009672_abnormal_birth_weight1.45294479
52MP0003984_embryonic_growth_retardation1.44596832
53MP0002088_abnormal_embryonic_growth/wei1.43042693
54MP0005275_abnormal_skin_tensile1.42243436
55MP0001672_abnormal_embryogenesis/_devel1.41042913
56MP0005380_embryogenesis_phenotype1.41042913
57MP0004036_abnormal_muscle_relaxation1.40084699
58MP0003091_abnormal_cell_migration1.39188451
59MP0000015_abnormal_ear_pigmentation1.38971795
60MP0004147_increased_porphyrin_level1.37551171
61MP0003806_abnormal_nucleotide_metabolis1.37125833
62MP0003567_abnormal_fetal_cardiomyocyte1.34885233
63MP0004957_abnormal_blastocyst_morpholog1.33142769
64MP0004233_abnormal_muscle_weight1.30121741
65MP0001544_abnormal_cardiovascular_syste1.27972504
66MP0005385_cardiovascular_system_phenoty1.27972504
67MP0008775_abnormal_heart_ventricle1.27739863
68MP0000759_abnormal_skeletal_muscle1.25995701
69MP0004197_abnormal_fetal_growth/weight/1.25258486
70MP0002108_abnormal_muscle_morphology1.24908936
71MP0003045_fibrosis1.24751962
72MP0000733_abnormal_muscle_development1.22643565
73MP0006036_abnormal_mitochondrial_physio1.21672193
74MP0005266_abnormal_metabolism1.21214704
75MP0009780_abnormal_chondrocyte_physiolo1.21194576
76MP0002106_abnormal_muscle_physiology1.18622837
77MP0003329_amyloid_beta_deposits1.18367503
78MP0002118_abnormal_lipid_homeostasis1.17851532
79MP0006138_congestive_heart_failure1.17420957
80MP0000013_abnormal_adipose_tissue1.16835412
81MP0001697_abnormal_embryo_size1.16703896
82MP0005058_abnormal_lysosome_morphology1.14998054
83MP0005165_increased_susceptibility_to1.14970257
84MP0009115_abnormal_fat_cell1.14687124
85MP0008961_abnormal_basal_metabolism1.14626585
86MP0002132_abnormal_respiratory_system1.14471525
87MP0003191_abnormal_cellular_cholesterol1.13278536
88MP0000003_abnormal_adipose_tissue1.12441849
89MP0002086_abnormal_extraembryonic_tissu1.12197812
90MP0001348_abnormal_lacrimal_gland1.11945463
91MP0000350_abnormal_cell_proliferation1.11086851
92MP0002127_abnormal_cardiovascular_syste1.09711772
93MP0002970_abnormal_white_adipose1.09654952
94MP0003566_abnormal_cell_adhesion1.09394096
95MP0005620_abnormal_muscle_contractility1.09307069
96MP0005319_abnormal_enzyme/_coenzyme1.09219003
97MP0002972_abnormal_cardiac_muscle1.05339790
98MP0004484_altered_response_of1.04745969
99MP0000343_altered_response_to1.03494937
100MP0002080_prenatal_lethality1.03016866
101MP0002909_abnormal_adrenal_gland1.01755816
102MP0005334_abnormal_fat_pad0.97659963
103MP0000266_abnormal_heart_morphology0.97627136
104MP0010030_abnormal_orbit_morphology0.95798213
105MP0000598_abnormal_liver_morphology0.95396169
106MP0001849_ear_inflammation0.95279974
107MP0005332_abnormal_amino_acid0.94911203
108MP0002877_abnormal_melanocyte_morpholog0.93772121
109MP0002084_abnormal_developmental_patter0.93027102
110MP0002295_abnormal_pulmonary_circulatio0.91448871
111MP0009053_abnormal_anal_canal0.91405860
112MP0000604_amyloidosis0.90362766
113MP0003186_abnormal_redox_activity0.88966819
114MP0003453_abnormal_keratinocyte_physiol0.88907945
115MP0002085_abnormal_embryonic_tissue0.88612611
116MP0002697_abnormal_eye_size0.88261477
117MP0003959_abnormal_lean_body0.87938947
118MP0009278_abnormal_bone_marrow0.87481061
119MP0005171_absent_coat_pigmentation0.87073661
120MP0005197_abnormal_uvea_morphology0.86077782
121MP0005369_muscle_phenotype0.85587447
122MP0003828_pulmonary_edema0.84830542
123MP0009703_decreased_birth_body0.83785194
124MP0005397_hematopoietic_system_phenotyp0.82798253
125MP0001545_abnormal_hematopoietic_system0.82798253
126MP0005187_abnormal_penis_morphology0.82693189
127MP0002060_abnormal_skin_morphology0.82205505
128MP0001299_abnormal_eye_distance/0.81520324
129MP0003300_gastrointestinal_ulcer0.81442671
130MP0003123_paternal_imprinting0.80028124
131MP0008875_abnormal_xenobiotic_pharmacok0.79617655
132MP0008007_abnormal_cellular_replicative0.79209633
133MP0000569_abnormal_digit_pigmentation0.77912335
134MP0001958_emphysema0.77224362
135MP0002078_abnormal_glucose_homeostasis0.77165420
136MP0010234_abnormal_vibrissa_follicle0.75540989
137MP0001915_intracranial_hemorrhage0.74979136
138MP0005193_abnormal_anterior_eye0.74059437
139MP0001661_extended_life_span0.73704493
140MP0004808_abnormal_hematopoietic_stem0.71965655
141MP0002234_abnormal_pharynx_morphology0.70458127
142MP0005584_abnormal_enzyme/coenzyme_acti0.69824725
143MP0004085_abnormal_heartbeat0.68929182
144MP0006082_CNS_inflammation0.68389603
145MP0001666_abnormal_nutrient_absorption0.68079073
146MP0003879_abnormal_hair_cell0.66890689
147MP0006035_abnormal_mitochondrial_morpho0.66138022
148MP0005023_abnormal_wound_healing0.63797425
149MP0003137_abnormal_impulse_conducting0.61915803
150MP0000358_abnormal_cell_content/0.59787855
151MP0003690_abnormal_glial_cell0.58982479
152MP0004043_abnormal_pH_regulation0.58101861

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)5.76933929
2Abnormality of skeletal muscle fiber size (HP:0012084)4.34985577
3Myoglobinuria (HP:0002913)4.34858231
4Increased variability in muscle fiber diameter (HP:0003557)4.22138855
5EMG: myopathic abnormalities (HP:0003458)3.97747316
6Rhabdomyolysis (HP:0003201)3.96420733
7Centrally nucleated skeletal muscle fibers (HP:0003687)3.93862954
8Hyperglycinuria (HP:0003108)3.78901895
9Hypoglycemic coma (HP:0001325)3.61564425
10Ragged-red muscle fibers (HP:0003200)3.43620483
11Hyporeflexia of lower limbs (HP:0002600)3.42347356
12Increased connective tissue (HP:0009025)3.38542592
13Exercise-induced muscle cramps (HP:0003710)3.35691844
14Abnormality of glycine metabolism (HP:0010895)3.35536350
15Abnormality of serine family amino acid metabolism (HP:0010894)3.35536350
16Hyperglycinemia (HP:0002154)3.32191290
17Exercise-induced myalgia (HP:0003738)3.25171380
18Flat cornea (HP:0007720)3.08230267
19Hyperammonemia (HP:0001987)3.05563594
20Poikilocytosis (HP:0004447)3.02331012
21Difficulty running (HP:0009046)2.97802833
22Ventricular tachycardia (HP:0004756)2.95901023
23Ketosis (HP:0001946)2.94999625
24Hypoalphalipoproteinemia (HP:0003233)2.91479712
25Hyperacusis (HP:0010780)2.90893469
26Sudden death (HP:0001699)2.90617619
27Reticulocytosis (HP:0001923)2.88050764
28Abnormality of fatty-acid metabolism (HP:0004359)2.87466075
29Deep venous thrombosis (HP:0002625)2.86955289
30Mildly elevated creatine phosphokinase (HP:0008180)2.80006564
31Nephritis (HP:0000123)2.80000909
32Paralysis (HP:0003470)2.71243052
33Ketoacidosis (HP:0001993)2.70653700
34Xanthomatosis (HP:0000991)2.69957240
35Protrusio acetabuli (HP:0003179)2.67662562
36Insomnia (HP:0100785)2.66439766
37Muscle fiber splitting (HP:0003555)2.64523409
38Atrioventricular block (HP:0001678)2.64260653
39Abnormality of dicarboxylic acid metabolism (HP:0010995)2.63836996
40Dicarboxylic aciduria (HP:0003215)2.63836996
41Bladder diverticulum (HP:0000015)2.62776995
42Elfin facies (HP:0004428)2.61699613
43Neck muscle weakness (HP:0000467)2.56468480
44Right ventricular cardiomyopathy (HP:0011663)2.55846010
45Difficulty climbing stairs (HP:0003551)2.54546898
46Cerebral inclusion bodies (HP:0100314)2.52487322
47Renovascular hypertension (HP:0100817)2.51507635
48Ulnar deviation of the wrist (HP:0003049)2.50196932
49Abnormality of the calf musculature (HP:0001430)2.49987720
50Abnormality of liposaccharide metabolism (HP:0010968)2.49738181
51Abnormality of glycosphingolipid metabolism (HP:0004343)2.49738181
52Abnormality of glycolipid metabolism (HP:0010969)2.49738181
53Glomerulonephritis (HP:0000099)2.49181341
54Scapular winging (HP:0003691)2.49088091
55Polycythemia (HP:0001901)2.48987348
56Testicular atrophy (HP:0000029)2.48501182
57Myopathic facies (HP:0002058)2.48412449
58Cholelithiasis (HP:0001081)2.46671747
59Alacrima (HP:0000522)2.43602682
60Multiple enchondromatosis (HP:0005701)2.42383156
61Hyperglycemia (HP:0003074)2.41681335
62Hypoplasia of the iris (HP:0007676)2.39287105
63Type 1 muscle fiber predominance (HP:0003803)2.38630287
64Distal arthrogryposis (HP:0005684)2.38592174
65Neuroendocrine neoplasm (HP:0100634)2.38484346
66Premature rupture of membranes (HP:0001788)2.37851226
67Hypokinesia (HP:0002375)2.37624315
68Spinal rigidity (HP:0003306)2.36118721
69Hypolipoproteinemia (HP:0010981)2.35078853
70Toxemia of pregnancy (HP:0100603)2.34196182
71Distal lower limb muscle weakness (HP:0009053)2.31289346
72Distal lower limb amyotrophy (HP:0008944)2.29685463
73Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.28058184
74Nausea (HP:0002018)2.26192280
75Vertebral compression fractures (HP:0002953)2.24912847
76Generalized amyotrophy (HP:0003700)2.24574794
77Calf muscle hypertrophy (HP:0008981)2.22615783
78Polar cataract (HP:0010696)2.21439314
79Generalized muscle weakness (HP:0003324)2.21329695
80Lipoatrophy (HP:0100578)2.20432210
81Decreased lacrimation (HP:0000633)2.19633905
82Bundle branch block (HP:0011710)2.19471127
83Abnormality of the lower motor neuron (HP:0002366)2.13757949
84Abnormality of serum amino acid levels (HP:0003112)2.13154755
85Abnormality of the left ventricular outflow tract (HP:0011103)2.13059966
86Subaortic stenosis (HP:0001682)2.13059966
87Abnormal gallbladder morphology (HP:0012437)2.12360540
88Areflexia of lower limbs (HP:0002522)2.11474368
89Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.11180864
90Albinism (HP:0001022)2.09469018
91Acanthocytosis (HP:0001927)2.07610872
92Renal duplication (HP:0000075)2.07506053
93Abnormality of monocarboxylic acid metabolism (HP:0010996)2.07358307
94Hepatocellular carcinoma (HP:0001402)2.06925314
95Intrahepatic cholestasis (HP:0001406)2.06811538
96Hamartoma of the eye (HP:0010568)2.06250881
97Pseudobulbar signs (HP:0002200)2.03032772
98Neoplasm of the peripheral nervous system (HP:0100007)2.02916640
99Absent phalangeal crease (HP:0006109)2.02452006
100Lymphangioma (HP:0100764)2.01562116
101Muscle hypertrophy of the lower extremities (HP:0008968)2.01433736
102Pheochromocytoma (HP:0002666)2.00731768
103Hyperlipoproteinemia (HP:0010980)2.00351986
104Ankle contracture (HP:0006466)2.00202622
105Epidermoid cyst (HP:0200040)1.99910532
106Ependymoma (HP:0002888)1.99887817
107EMG: neuropathic changes (HP:0003445)1.99410404
108Neonatal death (HP:0003811)1.99268936
109Spastic diplegia (HP:0001264)1.98697672
110Myotonia (HP:0002486)1.98378016
111Asymmetric septal hypertrophy (HP:0001670)1.98196442
112Cubitus valgus (HP:0002967)1.97854957
113Hypochromic microcytic anemia (HP:0004840)1.97236615
114Heart block (HP:0012722)1.96516325
115Hypertriglyceridemia (HP:0002155)1.94643214
116Generalized aminoaciduria (HP:0002909)1.94223829
117Adenoma sebaceum (HP:0009720)1.93640558
118Angiofibromas (HP:0010615)1.93640558
119Progressive muscle weakness (HP:0003323)1.93420387
120Muscle fiber inclusion bodies (HP:0100299)1.93311895
121Nonprogressive disorder (HP:0003680)1.93131458
122Cerebral aneurysm (HP:0004944)1.93066301
123Bowel diverticulosis (HP:0005222)1.92398533
124Back pain (HP:0003418)1.91713844
125Dysmetric saccades (HP:0000641)1.91471057
126Progressive external ophthalmoplegia (HP:0000590)1.91146604
127Conjunctival hamartoma (HP:0100780)1.90316729
128Muscle stiffness (HP:0003552)1.90257644
129Abnormality of glycolysis (HP:0004366)1.89804175
130Abnormality of the 4th metacarpal (HP:0010012)1.89456266
131Gout (HP:0001997)1.88942061
132Round ear (HP:0100830)1.87355630
133Rimmed vacuoles (HP:0003805)1.87160839
134Patellar dislocation (HP:0002999)1.86622796
135Cardiovascular calcification (HP:0011915)1.86574116
136Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.86258492
137Abnormal atrioventricular conduction (HP:0005150)1.86137645
138Prenatal maternal abnormality (HP:0002686)1.85610341
139Insulin resistance (HP:0000855)1.85552015
140Vascular calcification (HP:0004934)1.84490441
141Overriding aorta (HP:0002623)1.83534797
142Enlarged penis (HP:0000040)1.83005464
143Cerebral hemorrhage (HP:0001342)1.82005634
144Hypobetalipoproteinemia (HP:0003563)1.81118290
145Abnormality of the salivary glands (HP:0010286)1.80694485
146Rectal prolapse (HP:0002035)1.79951269
147Hyperkalemia (HP:0002153)1.79708380
148Increased serum pyruvate (HP:0003542)1.78836760
149Abnormality of the heme biosynthetic pathway (HP:0010472)1.78128129
150Aplasia involving bones of the extremities (HP:0009825)1.77579382
151Aplasia involving bones of the upper limbs (HP:0009823)1.77579382
152Aplasia of the phalanges of the hand (HP:0009802)1.77579382
153Increased nuchal translucency (HP:0010880)1.77041441
154Foot dorsiflexor weakness (HP:0009027)1.76356657
155Dilated cardiomyopathy (HP:0001644)1.75022019
156Insulin-resistant diabetes mellitus (HP:0000831)1.74330474
157Weak cry (HP:0001612)1.73716985
158Abnormality of reticulocytes (HP:0004312)1.73226220
159Abnormal cartilage morphology (HP:0002763)1.73188063
160Astrocytoma (HP:0009592)1.71063153
161Abnormality of the astrocytes (HP:0100707)1.71063153
162Hyperbilirubinemia (HP:0002904)1.71039606
163Abnormality of sulfur amino acid metabolism (HP:0004339)1.69350271
164Palpitations (HP:0001962)1.68665503

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.76190841
2PKN24.11046773
3EEF2K3.77282957
4LIMK13.70530522
5MAP3K103.09415868
6MOS2.81360407
7TTN2.61631955
8CDK82.60155157
9BCKDK2.55893848
10EPHA32.33836257
11NEK12.33748854
12PDK32.25383778
13PDK42.25383778
14LATS12.10256578
15NEK22.06509304
16CDC42BPA2.03337100
17CLK12.02357460
18EPHB12.01571001
19CDK121.99877920
20SIK11.80751900
21GRK71.79558900
22TRPM71.78980430
23ERN11.71554904
24CDK41.54704328
25MAP2K31.54308108
26CDC71.53855342
27IRAK31.51750498
28MAP3K21.48421400
29FLT31.45302582
30MST41.43145633
31NTRK11.36620996
32MAPKAPK31.35174396
33ZAP701.34302464
34CAMK1D1.33748849
35LATS21.31890086
36EIF2AK31.30294010
37STK31.29122203
38MTOR1.25849800
39EIF2AK11.25759998
40MET1.25087481
41CDK61.25023820
42FGFR41.23352678
43MYLK1.21434581
44PTK61.17602596
45TTK1.15839882
46LMTK21.15397916
47STK41.11131457
48RIPK11.08964469
49JAK11.07747025
50PDGFRA1.07340483
51KSR11.07248223
52RPS6KB21.07173134
53MAP3K71.05615049
54MAPK111.05325905
55STK101.05024020
56OBSCN1.03569958
57BUB11.02845329
58RAF11.02522406
59MAP3K81.00850753
60TAOK10.97186873
61ROCK20.94358515
62SRPK10.92596104
63PRKAA10.92376929
64ABL20.89717331
65MAP3K10.89115197
66PHKG20.88134860
67PHKG10.88134860
68PIK3CG0.88089235
69ICK0.87811943
70PDK20.86309622
71RPS6KA40.85508637
72BLK0.84459341
73PRKAA20.83297213
74ALK0.83037143
75BRSK20.81668163
76TBK10.81408520
77NEK90.78890544
78CAMKK20.78068526
79STK160.77850399
80PRPF4B0.76747265
81AURKB0.73364736
82PLK10.72941486
83ERBB40.72408580
84STK38L0.72334556
85PRKD30.71486302
86MAP2K10.70297525
87LRRK20.69845789
88AKT20.68085100
89DMPK0.67768374
90DYRK30.67266805
91ILK0.67150916
92SCYL20.67126018
93STK380.67050060
94CDK90.66737328
95RET0.66507481
96FGFR10.66338179
97JAK20.65299742
98MAP3K30.64224811
99CAMK1G0.63822030
100EIF2AK20.63014896
101MAP3K120.62831290
102PDPK10.61996923
103CDK70.61656816
104MST1R0.60515514
105TESK10.59856006
106WEE10.59347211
107ARAF0.59142394
108BRSK10.58756625
109FGFR30.58484354
110MAP3K50.57906277
111PRKD20.57462691
112CHEK10.57359649
113BMX0.55870009
114PASK0.55721173
115MAP3K60.55310699
116PIM10.54850521
117TIE10.54709191
118TAOK20.52305497
119EPHA20.50749815
120PAK40.49735033
121STK240.49311698
122MAP2K40.49263478
123TGFBR20.48875881
124CHEK20.48415205
125MAP4K10.48135549
126ATR0.47605256
127DDR20.47434276
128SGK30.46205290
129PDGFRB0.46162379
130FER0.46008053
131ROCK10.45495980
132PTK20.45076891
133MAPKAPK20.44665489
134RPS6KA10.44117412
135KDR0.43988217
136DYRK1B0.42982494
137MAP3K110.42730653
138CAMK2B0.42235169
139PAK20.42111432
140CDK20.41936359
141MAPK120.41175585
142TYK20.40436307
143ERBB20.39855886
144YES10.39025245
145ATM0.35947134
146RPS6KA20.35113128
147MAP3K90.35071592
148KSR20.34236674
149MELK0.33878928
150MAP2K60.33464740
151IRAK40.32319746
152PINK10.32169704
153PRKD10.31854989
154AKT30.30736566
155PAK60.30477213

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.77100150
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.55312706
3Fatty acid degradation_Homo sapiens_hsa000713.07842521
4Propanoate metabolism_Homo sapiens_hsa006402.99377293
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.89365026
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.77927563
7Fatty acid metabolism_Homo sapiens_hsa012122.56902900
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.55761304
9Carbon metabolism_Homo sapiens_hsa012002.48945248
10PPAR signaling pathway_Homo sapiens_hsa033202.13154307
11Biosynthesis of amino acids_Homo sapiens_hsa012302.11048655
12Circadian rhythm_Homo sapiens_hsa047102.06624467
13Nitrogen metabolism_Homo sapiens_hsa009102.05067248
14Sulfur metabolism_Homo sapiens_hsa009201.84215830
15Pyruvate metabolism_Homo sapiens_hsa006201.82334706
16Vitamin B6 metabolism_Homo sapiens_hsa007501.80906561
17Arginine biosynthesis_Homo sapiens_hsa002201.80383870
18Lysine degradation_Homo sapiens_hsa003101.80260843
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.79097973
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.69340098
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.67177439
22Renal cell carcinoma_Homo sapiens_hsa052111.65903865
23ECM-receptor interaction_Homo sapiens_hsa045121.63694560
24Butanoate metabolism_Homo sapiens_hsa006501.61356950
25Selenocompound metabolism_Homo sapiens_hsa004501.59581322
26Tryptophan metabolism_Homo sapiens_hsa003801.54065249
27Focal adhesion_Homo sapiens_hsa045101.51784879
28Other glycan degradation_Homo sapiens_hsa005111.49327338
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.42548931
30Fatty acid biosynthesis_Homo sapiens_hsa000611.41239114
31Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.36909546
32beta-Alanine metabolism_Homo sapiens_hsa004101.36794834
33One carbon pool by folate_Homo sapiens_hsa006701.35000206
34Insulin resistance_Homo sapiens_hsa049311.33975998
35Pentose phosphate pathway_Homo sapiens_hsa000301.29068289
36AMPK signaling pathway_Homo sapiens_hsa041521.28112532
37Sulfur relay system_Homo sapiens_hsa041221.24189747
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.22559839
39Amoebiasis_Homo sapiens_hsa051461.21757207
40Adipocytokine signaling pathway_Homo sapiens_hsa049201.18435545
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.17863274
42Inositol phosphate metabolism_Homo sapiens_hsa005621.16250973
43Insulin signaling pathway_Homo sapiens_hsa049101.12604011
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.11989158
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.10965815
46Malaria_Homo sapiens_hsa051441.10205799
47Cell cycle_Homo sapiens_hsa041101.05837161
48RNA transport_Homo sapiens_hsa030131.05737967
49Central carbon metabolism in cancer_Homo sapiens_hsa052301.04636356
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.04179216
51Glucagon signaling pathway_Homo sapiens_hsa049221.04032145
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02484539
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.01870069
54mTOR signaling pathway_Homo sapiens_hsa041501.01474568
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.00857056
56Drug metabolism - other enzymes_Homo sapiens_hsa009831.00345824
57Fatty acid elongation_Homo sapiens_hsa000620.99989581
58Fat digestion and absorption_Homo sapiens_hsa049750.95875927
59Starch and sucrose metabolism_Homo sapiens_hsa005000.95170383
60Chronic myeloid leukemia_Homo sapiens_hsa052200.92659138
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92330811
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90880036
63Peroxisome_Homo sapiens_hsa041460.88298781
64Glycerolipid metabolism_Homo sapiens_hsa005610.88013844
65Prolactin signaling pathway_Homo sapiens_hsa049170.86213794
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86000270
67Pancreatic cancer_Homo sapiens_hsa052120.83752333
68Melanoma_Homo sapiens_hsa052180.82911239
69Phenylalanine metabolism_Homo sapiens_hsa003600.82044678
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77164956
71Regulation of autophagy_Homo sapiens_hsa041400.77057591
72DNA replication_Homo sapiens_hsa030300.76665566
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75678116
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74903622
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74017790
76Complement and coagulation cascades_Homo sapiens_hsa046100.73970829
77Fructose and mannose metabolism_Homo sapiens_hsa000510.73940955
78ABC transporters_Homo sapiens_hsa020100.68740439
79mRNA surveillance pathway_Homo sapiens_hsa030150.67677809
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.67657715
81Lysosome_Homo sapiens_hsa041420.67438011
82Small cell lung cancer_Homo sapiens_hsa052220.67278581
83p53 signaling pathway_Homo sapiens_hsa041150.65528306
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65494245
85Bile secretion_Homo sapiens_hsa049760.64425947
86Ovarian steroidogenesis_Homo sapiens_hsa049130.64061902
87VEGF signaling pathway_Homo sapiens_hsa043700.59976084
88Cardiac muscle contraction_Homo sapiens_hsa042600.59314568
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58781692
90Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.58485906
91Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57607714
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56846139
93Folate biosynthesis_Homo sapiens_hsa007900.56378260
94Caffeine metabolism_Homo sapiens_hsa002320.55505039
95Viral myocarditis_Homo sapiens_hsa054160.55382942
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54312737
97Thyroid cancer_Homo sapiens_hsa052160.54023451
98Hepatitis C_Homo sapiens_hsa051600.53665973
99Dorso-ventral axis formation_Homo sapiens_hsa043200.53472115
100Bladder cancer_Homo sapiens_hsa052190.53448298
101Base excision repair_Homo sapiens_hsa034100.53312880
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.53141751
103Dilated cardiomyopathy_Homo sapiens_hsa054140.52833904
104Systemic lupus erythematosus_Homo sapiens_hsa053220.52153758
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51866636
106Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51599651
107MicroRNAs in cancer_Homo sapiens_hsa052060.51598971
108Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51277167
109FoxO signaling pathway_Homo sapiens_hsa040680.51265917
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51211314
111Protein digestion and absorption_Homo sapiens_hsa049740.51188746
112Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50595348
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.49826742
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.49480598
115Non-small cell lung cancer_Homo sapiens_hsa052230.49223208
116HIF-1 signaling pathway_Homo sapiens_hsa040660.46928005
117TNF signaling pathway_Homo sapiens_hsa046680.46887642
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46871526
119Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46158676
120Toll-like receptor signaling pathway_Homo sapiens_hsa046200.45738296
121Endometrial cancer_Homo sapiens_hsa052130.44531952
122Galactose metabolism_Homo sapiens_hsa000520.44311296
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43004180
124Viral carcinogenesis_Homo sapiens_hsa052030.42901613
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41351910
126Tyrosine metabolism_Homo sapiens_hsa003500.40810435
127Adherens junction_Homo sapiens_hsa045200.40729608
128Acute myeloid leukemia_Homo sapiens_hsa052210.39952867
129Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38243264
130Type II diabetes mellitus_Homo sapiens_hsa049300.38058368
131Basal cell carcinoma_Homo sapiens_hsa052170.36941371
132HTLV-I infection_Homo sapiens_hsa051660.36253917
133Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35213040
134Arginine and proline metabolism_Homo sapiens_hsa003300.34351104
135Spliceosome_Homo sapiens_hsa030400.33939530
136Proteoglycans in cancer_Homo sapiens_hsa052050.33043997
137Hippo signaling pathway_Homo sapiens_hsa043900.32570145
138Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32157047
139Oocyte meiosis_Homo sapiens_hsa041140.32035501

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