BCL2L14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Overexpression of this gene has been shown to induce apoptosis in cells. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)8.05830254
2sperm motility (GO:0030317)7.86209032
3cell wall macromolecule metabolic process (GO:0044036)7.77523389
4cell wall macromolecule catabolic process (GO:0016998)7.77523389
5epithelial cilium movement (GO:0003351)6.70482675
6sperm-egg recognition (GO:0035036)6.66432289
7axonemal dynein complex assembly (GO:0070286)6.51403913
8binding of sperm to zona pellucida (GO:0007339)6.16639547
9multicellular organism reproduction (GO:0032504)6.11947724
10acrosome assembly (GO:0001675)6.03174269
11spermatid development (GO:0007286)5.99986019
12cell-cell recognition (GO:0009988)5.97878692
13acrosome reaction (GO:0007340)5.94982661
14regulation of cilium movement (GO:0003352)5.94127106
15plasma membrane fusion (GO:0045026)5.90190560
16response to pheromone (GO:0019236)5.63769014
17DNA deamination (GO:0045006)5.61467595
18transcription from mitochondrial promoter (GO:0006390)5.48348560
19proline biosynthetic process (GO:0006561)5.38265042
20motile cilium assembly (GO:0044458)5.37616738
21reproduction (GO:0000003)5.37349840
22epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.35727889
23fucose catabolic process (GO:0019317)5.16622448
24L-fucose metabolic process (GO:0042354)5.16622448
25L-fucose catabolic process (GO:0042355)5.16622448
26synaptonemal complex assembly (GO:0007130)5.10162627
27synaptonemal complex organization (GO:0070193)5.08412419
28cilium movement (GO:0003341)5.04065895
29cilium or flagellum-dependent cell motility (GO:0001539)4.90506966
30single strand break repair (GO:0000012)4.78633306
31behavioral response to nicotine (GO:0035095)4.77083703
32microtubule depolymerization (GO:0007019)4.61765086
33interferon-gamma secretion (GO:0072643)4.33186238
34piRNA metabolic process (GO:0034587)4.27860910
35indole-containing compound catabolic process (GO:0042436)4.27163594
36indolalkylamine catabolic process (GO:0046218)4.27163594
37tryptophan catabolic process (GO:0006569)4.27163594
38replication fork processing (GO:0031297)4.23517226
39male meiosis (GO:0007140)4.20481261
40kynurenine metabolic process (GO:0070189)4.19400077
41negative regulation of inclusion body assembly (GO:0090084)4.17715319
42spermatogenesis (GO:0007283)4.06820190
43male gamete generation (GO:0048232)4.05815809
44single fertilization (GO:0007338)4.04414567
45indolalkylamine metabolic process (GO:0006586)4.00828635
46proline metabolic process (GO:0006560)3.98200727
47cellular ketone body metabolic process (GO:0046950)3.85377237
48regulation of spindle checkpoint (GO:0090231)3.80402747
49fertilization (GO:0009566)3.79672261
50gamete generation (GO:0007276)3.77233306
51sperm capacitation (GO:0048240)3.76227865
52glycerol ether metabolic process (GO:0006662)3.76027647
53formation of translation preinitiation complex (GO:0001731)3.73668860
54maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.70336664
55regulation of inclusion body assembly (GO:0090083)3.69934215
56regulation of guanylate cyclase activity (GO:0031282)3.69138423
57tryptophan metabolic process (GO:0006568)3.59343678
58cellular biogenic amine catabolic process (GO:0042402)3.59047113
59amine catabolic process (GO:0009310)3.59047113
60chromosome condensation (GO:0030261)3.51507399
61platelet dense granule organization (GO:0060155)3.50673777
62male meiosis I (GO:0007141)3.48913712
63germ cell development (GO:0007281)3.45681634
64ketone body metabolic process (GO:1902224)3.45557160
65ether metabolic process (GO:0018904)3.44063914
66regulation of microtubule-based movement (GO:0060632)3.42384774
67positive regulation of guanylate cyclase activity (GO:0031284)3.42045819
68meiotic nuclear division (GO:0007126)3.41013061
69chromosome organization involved in meiosis (GO:0070192)3.39640117
70mitochondrial DNA metabolic process (GO:0032042)3.39314874
71regulation of RNA export from nucleus (GO:0046831)3.35991262
72GDP-mannose metabolic process (GO:0019673)3.32044896
73detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.31090642
74establishment of protein localization to mitochondrial membrane (GO:0090151)3.28887524
75detection of light stimulus involved in visual perception (GO:0050908)3.28760639
76detection of light stimulus involved in sensory perception (GO:0050962)3.28760639
77water-soluble vitamin biosynthetic process (GO:0042364)3.27463632
78positive regulation of chromosome segregation (GO:0051984)3.26876060
79intestinal epithelial cell development (GO:0060576)3.26468575
80DNA packaging (GO:0006323)3.26275772
81embryonic process involved in female pregnancy (GO:0060136)3.26073956
82somatic hypermutation of immunoglobulin genes (GO:0016446)3.25587867
83somatic diversification of immune receptors via somatic mutation (GO:0002566)3.25587867
84meiosis I (GO:0007127)3.24596951
85cellular process involved in reproduction in multicellular organism (GO:0022412)3.22256273
86positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.20606243
87positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.20606243
88positive regulation of mitotic sister chromatid separation (GO:1901970)3.20606243
89purine nucleobase biosynthetic process (GO:0009113)3.17488017
90protein polyglutamylation (GO:0018095)3.17346600
91respiratory chain complex IV assembly (GO:0008535)3.16852273
92maturation of 5.8S rRNA (GO:0000460)3.15006063
93organic cation transport (GO:0015695)3.12735509
94axoneme assembly (GO:0035082)3.11456891
95indole-containing compound metabolic process (GO:0042430)3.10673659
96spermatid nucleus differentiation (GO:0007289)3.08975877
97drug catabolic process (GO:0042737)3.07254526
98sulfation (GO:0051923)3.06335508
99ribosome biogenesis (GO:0042254)3.05928816
100positive regulation of protein homooligomerization (GO:0032464)3.05242861
101monoubiquitinated protein deubiquitination (GO:0035520)2.99459828
102mitotic G1 DNA damage checkpoint (GO:0031571)2.99295096
103positive regulation of prostaglandin secretion (GO:0032308)2.98639934
104negative regulation of telomere maintenance (GO:0032205)2.98061252
105meiotic cell cycle process (GO:1903046)2.97265776
106labyrinthine layer development (GO:0060711)2.96025082
107multicellular organismal reproductive process (GO:0048609)2.95798682
108exogenous drug catabolic process (GO:0042738)2.94400954
109viral mRNA export from host cell nucleus (GO:0046784)2.92887652
110mRNA cleavage (GO:0006379)2.92430276
111chaperone-mediated protein complex assembly (GO:0051131)2.91215031
112neural tube formation (GO:0001841)2.90904048
113establishment of apical/basal cell polarity (GO:0035089)2.88793131
114positive regulation of defense response to virus by host (GO:0002230)2.88290439
115cytochrome complex assembly (GO:0017004)2.88125645
116seminiferous tubule development (GO:0072520)2.87485928
117fucosylation (GO:0036065)2.86809894
118mitotic metaphase plate congression (GO:0007080)2.82981769
119regulation of integrin activation (GO:0033623)2.80290172
120meiotic cell cycle (GO:0051321)2.80243185
121mitotic sister chromatid segregation (GO:0000070)2.77961979
122kidney morphogenesis (GO:0060993)2.77321683
123sexual reproduction (GO:0019953)2.76257247
124positive regulation of fatty acid transport (GO:2000193)2.75862939
125DNA double-strand break processing (GO:0000729)2.75196532
126primary amino compound metabolic process (GO:1901160)2.74920076
127nucleobase biosynthetic process (GO:0046112)2.74532454
128sulfate transmembrane transport (GO:1902358)2.74391357
129DNA methylation involved in gamete generation (GO:0043046)2.74306268
130polyamine biosynthetic process (GO:0006596)2.73614767
131vitamin transmembrane transport (GO:0035461)2.72925950
132cytidine catabolic process (GO:0006216)2.72526389
133cytidine deamination (GO:0009972)2.72526389
134cytidine metabolic process (GO:0046087)2.72526389
135trophectodermal cell differentiation (GO:0001829)2.72287899
136regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.72264025
137guanosine-containing compound biosynthetic process (GO:1901070)2.71932717
138regulation of double-strand break repair via homologous recombination (GO:0010569)2.71241181
1393-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.70958024
140purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.70958024
141mitochondrial RNA metabolic process (GO:0000959)2.69853457
142cellular response to ATP (GO:0071318)2.69586273
143arginine metabolic process (GO:0006525)2.69340033
144preassembly of GPI anchor in ER membrane (GO:0016254)2.66871853
145G1 DNA damage checkpoint (GO:0044783)2.65538551
146protein complex biogenesis (GO:0070271)2.65423515
147phosphatidylinositol acyl-chain remodeling (GO:0036149)2.65298271
148protein localization to cilium (GO:0061512)2.65240920
149regulation of memory T cell differentiation (GO:0043380)2.64414645
150regulation of chromosome segregation (GO:0051983)2.64285140
151activated T cell proliferation (GO:0050798)2.63936239
152telomere maintenance via semi-conservative replication (GO:0032201)2.63647400
153cellular response to exogenous dsRNA (GO:0071360)2.61906936
154cellular response to interferon-beta (GO:0035458)2.61751567
155rRNA catabolic process (GO:0016075)2.60449584
156proline transport (GO:0015824)2.60249852
157alanine transport (GO:0032328)2.57654755
158neuronal action potential (GO:0019228)2.57563600
159transepithelial transport (GO:0070633)2.57141123
160NAD biosynthetic process (GO:0009435)2.54874760
161nephron epithelium morphogenesis (GO:0072088)2.52866910
162nephron tubule morphogenesis (GO:0072078)2.52866910
163retinal cone cell development (GO:0046549)2.51688432
164mitochondrial respiratory chain complex I assembly (GO:0032981)2.49843147
165NADH dehydrogenase complex assembly (GO:0010257)2.49843147
166mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.49843147
167cAMP catabolic process (GO:0006198)2.49645261
168positive regulation of icosanoid secretion (GO:0032305)2.49261180
169negative regulation of mast cell activation (GO:0033004)2.48969420
170arginine catabolic process (GO:0006527)2.48276176
171reflex (GO:0060004)2.48152609
172serotonin metabolic process (GO:0042428)2.47178446
173benzene-containing compound metabolic process (GO:0042537)2.47053671
174photoreceptor cell maintenance (GO:0045494)2.43067097
175phosphatidylserine acyl-chain remodeling (GO:0036150)2.42469797
176dopamine transport (GO:0015872)2.42372946
177regulation of cGMP biosynthetic process (GO:0030826)2.41409748
178pyrimidine ribonucleoside catabolic process (GO:0046133)2.41297878
179mannosylation (GO:0097502)2.40378756
180mitochondrial respiratory chain complex assembly (GO:0033108)2.38920655
181regulation of hexokinase activity (GO:1903299)2.38376127
182regulation of glucokinase activity (GO:0033131)2.38376127
183regulation of action potential (GO:0098900)2.38102588
184vitamin biosynthetic process (GO:0009110)2.37401345
185behavioral response to ethanol (GO:0048149)2.36340685
186GPI anchor metabolic process (GO:0006505)2.35827008
187C4-dicarboxylate transport (GO:0015740)2.34936239
188aromatic amino acid family catabolic process (GO:0009074)2.34289937

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.67654372
2ZNF274_21170338_ChIP-Seq_K562_Hela3.60270304
3VDR_22108803_ChIP-Seq_LS180_Human3.34212508
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.80440292
5SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.66821844
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.59417551
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.57935204
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.53220294
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.45096088
10GBX2_23144817_ChIP-Seq_PC3_Human2.38718550
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.36255306
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.35880948
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.31081154
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.27433466
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.24409540
16E2F7_22180533_ChIP-Seq_HELA_Human2.19516541
17IGF1R_20145208_ChIP-Seq_DFB_Human2.19424548
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.18133559
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.11848687
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.08929866
21NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.08900048
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.07277122
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.00817787
24CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.95759727
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94494492
26ZNF263_19887448_ChIP-Seq_K562_Human1.93944331
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93929800
28KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.92328681
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.91258463
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.90287145
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.90236534
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.90090987
33* P300_19829295_ChIP-Seq_ESCs_Human1.83972228
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83149788
35ER_23166858_ChIP-Seq_MCF-7_Human1.80499832
36MYC_19030024_ChIP-ChIP_MESCs_Mouse1.79128528
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.77490201
38TAF15_26573619_Chip-Seq_HEK293_Human1.77373280
39STAT3_1855785_ChIP-Seq_MESCs_Mouse1.76030509
40FUS_26573619_Chip-Seq_HEK293_Human1.75985586
41EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.75600032
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.69021347
43DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.66972939
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.65790742
45EWS_26573619_Chip-Seq_HEK293_Human1.65561022
46BCAT_22108803_ChIP-Seq_LS180_Human1.65127954
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.63648370
48HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.58180872
49SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58068426
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57922147
51TET1_21451524_ChIP-Seq_MESCs_Mouse1.57231593
52FOXA1_27270436_Chip-Seq_PROSTATE_Human1.56961741
53FOXA1_25329375_ChIP-Seq_VCAP_Human1.56961741
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.51993545
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51802089
56FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50895731
57CBP_20019798_ChIP-Seq_JUKART_Human1.50813984
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50813984
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.50281738
60MYCN_18555785_ChIP-Seq_MESCs_Mouse1.49709220
61NR3C1_21868756_ChIP-Seq_MCF10A_Human1.48777324
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47447097
63EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.46334995
64PU.1_20513432_ChIP-Seq_Bcells_Mouse1.46005546
65CREB1_15753290_ChIP-ChIP_HEK293T_Human1.45994899
66RARA_24833708_ChIP-Seq_LIVER_Mouse1.45304620
67GABP_19822575_ChIP-Seq_HepG2_Human1.44846767
68YY1_22570637_ChIP-Seq_MALME-3M_Human1.43279383
69RXRA_24833708_ChIP-Seq_LIVER_Mouse1.43075324
70NANOG_19829295_ChIP-Seq_ESCs_Human1.42031249
71SOX2_19829295_ChIP-Seq_ESCs_Human1.42031249
72FOXA1_21572438_ChIP-Seq_LNCaP_Human1.41236338
73KAP1_22055183_ChIP-Seq_ESCs_Mouse1.40836890
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40533445
75TCF4_22108803_ChIP-Seq_LS180_Human1.39605773
76STAT3_23295773_ChIP-Seq_U87_Human1.39010791
77EZH2_22144423_ChIP-Seq_EOC_Human1.38361899
78IRF1_19129219_ChIP-ChIP_H3396_Human1.37864692
79E2F4_17652178_ChIP-ChIP_JURKAT_Human1.37811890
80SPI1_26923725_Chip-Seq_HPCs_Mouse1.36870941
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.36011782
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35984427
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.35913076
84CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.35745598
85NANOG_21062744_ChIP-ChIP_HESCs_Human1.35699802
86TP53_22573176_ChIP-Seq_HFKS_Human1.35440874
87AR_25329375_ChIP-Seq_VCAP_Human1.34863617
88EGR1_23403033_ChIP-Seq_LIVER_Mouse1.34651064
89TCF4_23295773_ChIP-Seq_U87_Human1.34552477
90PIAS1_25552417_ChIP-Seq_VCAP_Human1.34401422
91ETV2_25802403_ChIP-Seq_MESCs_Mouse1.33751489
92FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.33537057
93EZH2_27294783_Chip-Seq_NPCs_Mouse1.32041084
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31868550
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30358565
96GABP_17652178_ChIP-ChIP_JURKAT_Human1.29584017
97KDM5A_27292631_Chip-Seq_BREAST_Human1.29421745
98PHF8_20622854_ChIP-Seq_HELA_Human1.29169940
99EST1_17652178_ChIP-ChIP_JURKAT_Human1.28345881
100SMAD4_21799915_ChIP-Seq_A2780_Human1.28279059
101GATA3_21878914_ChIP-Seq_MCF-7_Human1.27947090
102BCOR_27268052_Chip-Seq_Bcells_Human1.27879915
103RARB_24833708_ChIP-Seq_LIVER_Mouse1.27844098
104AR_21909140_ChIP-Seq_LNCAP_Human1.27231694
105AUTS2_25519132_ChIP-Seq_293T-REX_Human1.27227817
106KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25937028
107SALL1_21062744_ChIP-ChIP_HESCs_Human1.25742698
108AR_20517297_ChIP-Seq_VCAP_Human1.25697860
109GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24485827
110NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.23710616
111PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23550844
112VDR_23849224_ChIP-Seq_CD4+_Human1.23263662
113CDX2_22108803_ChIP-Seq_LS180_Human1.22522856
114* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.22256125
115FLI1_21867929_ChIP-Seq_CD8_Mouse1.22020557
116SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.21906110
117SMAD4_21741376_ChIP-Seq_EPCs_Human1.21544614
118SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.20926434
119BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20822431
120TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.20476029
121KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.20432796
122KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.20432796
123KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.20432796
124CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20391950
125SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20193694
126* NCOR_22424771_ChIP-Seq_293T_Human1.20041928
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19958422
128POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19958422
129SMAD3_21741376_ChIP-Seq_EPCs_Human1.19802961
130PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18711276
131HOXB7_26014856_ChIP-Seq_BT474_Human1.18360148
132ETS1_21867929_ChIP-Seq_TH2_Mouse1.18145069
133MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17907977
134* RUNX2_22187159_ChIP-Seq_PCA_Human1.17462302
135POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16952357
136* PRDM14_20953172_ChIP-Seq_ESCs_Human1.15936960
137CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15933346
138TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15851147
139SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14358680
140MYC_18940864_ChIP-ChIP_HL60_Human1.14199570
141MYC_19829295_ChIP-Seq_ESCs_Human1.14186361
142CBX2_27304074_Chip-Seq_ESCs_Mouse1.13966757
143CRX_20693478_ChIP-Seq_RETINA_Mouse1.13944832
144STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13695477
145CTCF_26484167_Chip-Seq_Bcells_Mouse1.13382456
146CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.13333203
147POU5F1_16518401_ChIP-PET_MESCs_Mouse1.13271555
148REST_21632747_ChIP-Seq_MESCs_Mouse1.12628721
149NANOG_20526341_ChIP-Seq_ESCs_Human1.12504117
150ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12449598
151NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.12389619
152NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.11775086
153KAP1_27257070_Chip-Seq_ESCs_Mouse1.11200747
154GATA3_26560356_Chip-Seq_TH2_Human1.10520003
155PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10514961
156TAF2_19829295_ChIP-Seq_ESCs_Human1.09369158
157SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.09073266
158MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.08703284
159P53_22387025_ChIP-Seq_ESCs_Mouse1.08673034
160TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08626534
161XRN2_22483619_ChIP-Seq_HELA_Human1.07355467
162CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07272659
163EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06987554
164STAT3_18555785_Chip-Seq_ESCs_Mouse1.06705320
165* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06416874
166DCP1A_22483619_ChIP-Seq_HELA_Human1.06254001
167NANOG_18555785_Chip-Seq_ESCs_Mouse1.05923507
168GATA1_26923725_Chip-Seq_HPCs_Mouse1.05033639
169CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.04622626
170TCF3_18692474_ChIP-Seq_MESCs_Mouse1.04420925
171ETV1_20927104_ChIP-Seq_GIST48_Human1.03403843
172E2F1_20622854_ChIP-Seq_HELA_Human1.03013528
173POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02978768
174SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01995121
175E2F1_18555785_ChIP-Seq_MESCs_Mouse1.01735924
176FLI1_21867929_ChIP-Seq_TH2_Mouse1.01571964
177ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01523436
178* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.01152125
179KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.01085259
180GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.00443452
181PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99984858
182SOX2_22085726_ChIP-Seq_NPCs_Mouse0.99676295
183GATA3_21867929_ChIP-Seq_CD8_Mouse0.99539191
184ERA_21632823_ChIP-Seq_H3396_Human0.99521685
185TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98669580
186NELFA_20434984_ChIP-Seq_ESCs_Mouse0.98285050
187* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.95875995
188SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93722020
189BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93581176
190CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93042504
191TTF2_22483619_ChIP-Seq_HELA_Human0.92062713
192* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.91896386
193BCL6_27268052_Chip-Seq_Bcells_Human0.91031545
194STAT1_20625510_ChIP-Seq_HELA_Human0.90463357
195PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89584713
196TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.89346852
197PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.88208147

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.56335863
2MP0008057_abnormal_DNA_replication4.40503586
3MP0001929_abnormal_gametogenesis3.58990214
4MP0003698_abnormal_male_reproductive3.56738732
5MP0003693_abnormal_embryo_hatching3.52995049
6MP0008877_abnormal_DNA_methylation3.37748310
7MP0003111_abnormal_nucleus_morphology3.00104636
8MP0003195_calcinosis2.85457139
9MP0010094_abnormal_chromosome_stability2.85062673
10MP0004957_abnormal_blastocyst_morpholog2.68812854
11MP0004147_increased_porphyrin_level2.67748398
12MP0009278_abnormal_bone_marrow2.56100741
13MP0008058_abnormal_DNA_repair2.55334768
14MP0002009_preneoplasia2.52450975
15MP0004043_abnormal_pH_regulation2.48185125
16MP0002210_abnormal_sex_determination2.48179927
17MP0003718_maternal_effect2.42802743
18MP0003786_premature_aging2.34773255
19MP0005360_urolithiasis2.33611454
20MP0001145_abnormal_male_reproductive2.32959844
21MP0002876_abnormal_thyroid_physiology2.28990738
22MP0002653_abnormal_ependyma_morphology2.24638057
23MP0005085_abnormal_gallbladder_physiolo2.23645006
24MP0005551_abnormal_eye_electrophysiolog2.21822369
25MP0002161_abnormal_fertility/fecundity2.17455497
26MP0002102_abnormal_ear_morphology2.14272616
27MP0008995_early_reproductive_senescence2.07428798
28MP0002837_dystrophic_cardiac_calcinosis2.04613389
29MP0003646_muscle_fatigue2.04375394
30MP0008875_abnormal_xenobiotic_pharmacok2.03543010
31MP0004233_abnormal_muscle_weight1.99862799
32MP0006082_CNS_inflammation1.98965371
33MP0003077_abnormal_cell_cycle1.98017021
34MP0000653_abnormal_sex_gland1.97420489
35MP0008872_abnormal_physiological_respon1.97190416
36MP0001501_abnormal_sleep_pattern1.96948649
37MP0001545_abnormal_hematopoietic_system1.86995925
38MP0005397_hematopoietic_system_phenotyp1.86995925
39MP0005645_abnormal_hypothalamus_physiol1.83853099
40MP0002638_abnormal_pupillary_reflex1.82856421
41MP0005671_abnormal_response_to1.69307829
42MP0003252_abnormal_bile_duct1.68140674
43MP0004885_abnormal_endolymph1.67791593
44MP0001485_abnormal_pinna_reflex1.61775625
45MP0001968_abnormal_touch/_nociception1.61322377
46MP0003136_yellow_coat_color1.60735676
47MP0004142_abnormal_muscle_tone1.59442984
48MP0009745_abnormal_behavioral_response1.57813679
49MP0008932_abnormal_embryonic_tissue1.57632065
50MP0002139_abnormal_hepatobiliary_system1.54583330
51MP0010030_abnormal_orbit_morphology1.53012322
52MP0001730_embryonic_growth_arrest1.48478512
53MP0003787_abnormal_imprinting1.47522926
54MP0005253_abnormal_eye_physiology1.46376216
55MP0002736_abnormal_nociception_after1.45730164
56MP0000427_abnormal_hair_cycle1.43071313
57MP0001986_abnormal_taste_sensitivity1.42856490
58MP0005646_abnormal_pituitary_gland1.42093876
59MP0001666_abnormal_nutrient_absorption1.40167174
60MP0005084_abnormal_gallbladder_morpholo1.39872029
61MP0000372_irregular_coat_pigmentation1.38641332
62MP0001672_abnormal_embryogenesis/_devel1.37543365
63MP0005380_embryogenesis_phenotype1.37543365
64MP0000569_abnormal_digit_pigmentation1.36860494
65MP0005377_hearing/vestibular/ear_phenot1.36635927
66MP0003878_abnormal_ear_physiology1.36635927
67MP0009046_muscle_twitch1.36107443
68MP0009785_altered_susceptibility_to1.34136758
69MP0004264_abnormal_extraembryonic_tissu1.34089631
70MP0005332_abnormal_amino_acid1.32440136
71MP0009764_decreased_sensitivity_to1.32100296
72MP0001697_abnormal_embryo_size1.31306598
73MP0000490_abnormal_crypts_of1.30694768
74MP0002796_impaired_skin_barrier1.28646810
75MP0000462_abnormal_digestive_system1.28311086
76MP0002272_abnormal_nervous_system1.28091809
77MP0010307_abnormal_tumor_latency1.26611690
78MP0003011_delayed_dark_adaptation1.26438026
79MP0004019_abnormal_vitamin_homeostasis1.25164159
80MP0000350_abnormal_cell_proliferation1.21028871
81MP0004742_abnormal_vestibular_system1.20878736
82MP0002086_abnormal_extraembryonic_tissu1.19278686
83MP0000230_abnormal_systemic_arterial1.18876827
84MP0010352_gastrointestinal_tract_polyps1.18864861
85MP0001293_anophthalmia1.18292609
86MP0002277_abnormal_respiratory_mucosa1.17927273
87MP0010329_abnormal_lipoprotein_level1.17594923
88MP0002733_abnormal_thermal_nociception1.15659463
89MP0004215_abnormal_myocardial_fiber1.15113793
90MP0008775_abnormal_heart_ventricle1.14995747
91MP0005171_absent_coat_pigmentation1.14947875
92MP0005379_endocrine/exocrine_gland_phen1.14448845
93MP0002084_abnormal_developmental_patter1.14117714
94MP0002735_abnormal_chemical_nociception1.12838951
95MP0001970_abnormal_pain_threshold1.12683475
96MP0002085_abnormal_embryonic_tissue1.10708735
97MP0005636_abnormal_mineral_homeostasis1.09864041
98MP0002254_reproductive_system_inflammat1.09413148
99MP0005670_abnormal_white_adipose1.09362598
100MP0002064_seizures1.08863989
101MP0003984_embryonic_growth_retardation1.08207075
102MP0005448_abnormal_energy_balance1.08153002
103MP0002080_prenatal_lethality1.07193858
104MP0005167_abnormal_blood-brain_barrier1.06201958
105MP0001873_stomach_inflammation1.06162499
106MP0002282_abnormal_trachea_morphology1.05666594
107MP0002088_abnormal_embryonic_growth/wei1.04212241
108MP0003119_abnormal_digestive_system1.03162868
109MP0001765_abnormal_ion_homeostasis1.02697878
110MP0002132_abnormal_respiratory_system1.02617297
111MP0002163_abnormal_gland_morphology1.02439183
112MP0001486_abnormal_startle_reflex1.00657561
113MP0002693_abnormal_pancreas_physiology0.99899061
114MP0010155_abnormal_intestine_physiology0.99362224
115MP0000579_abnormal_nail_morphology0.98825164
116MP0001800_abnormal_humoral_immune0.97938166
117MP0006276_abnormal_autonomic_nervous0.97857230
118MP0002938_white_spotting0.97474386
119MP0002160_abnormal_reproductive_system0.96227469
120MP0009840_abnormal_foam_cell0.95448251
121MP0002138_abnormal_hepatobiliary_system0.95304188
122MP0000631_abnormal_neuroendocrine_gland0.94537891
123MP0005076_abnormal_cell_differentiation0.94369369
124MP0002148_abnormal_hypersensitivity_rea0.93459547
125MP0002269_muscular_atrophy0.93129431
126MP0002928_abnormal_bile_duct0.92692496
127MP0005647_abnormal_sex_gland0.92438142
128MP0002557_abnormal_social/conspecific_i0.92182902
129MP0001664_abnormal_digestion0.91347787
130MP0000313_abnormal_cell_death0.91023316
131MP0004145_abnormal_muscle_electrophysio0.90816348
132MP0009333_abnormal_splenocyte_physiolog0.90647659
133MP0000383_abnormal_hair_follicle0.90435855
134MP0009643_abnormal_urine_homeostasis0.90032573
135MP0001835_abnormal_antigen_presentation0.89236450
136MP0005395_other_phenotype0.88114345
137MP0003453_abnormal_keratinocyte_physiol0.88062189
138MP0001905_abnormal_dopamine_level0.87783938
139MP0001790_abnormal_immune_system0.87781854
140MP0005387_immune_system_phenotype0.87781854
141MP0005075_abnormal_melanosome_morpholog0.87433806
142MP0002572_abnormal_emotion/affect_behav0.87381543
143MP0001663_abnormal_digestive_system0.87173715
144MP0008260_abnormal_autophagy0.86821976
145MP0005058_abnormal_lysosome_morphology0.86639018
146MP0002019_abnormal_tumor_incidence0.84878658
147MP0003567_abnormal_fetal_cardiomyocyte0.84152168
148MP0005174_abnormal_tail_pigmentation0.83891078
149MP0003183_abnormal_peptide_metabolism0.83335905
150MP0006292_abnormal_olfactory_placode0.82587260
151MP0003699_abnormal_female_reproductive0.81927341
152MP0008007_abnormal_cellular_replicative0.81825580
153MP0005389_reproductive_system_phenotype0.81689064
154MP0001764_abnormal_homeostasis0.81002646
155MP0004197_abnormal_fetal_growth/weight/0.79265274
156MP0003890_abnormal_embryonic-extraembry0.78646820
157MP0002396_abnormal_hematopoietic_system0.76108961
158MP0003941_abnormal_skin_development0.73035819
159MP0002166_altered_tumor_susceptibility0.71614072
160MP0006072_abnormal_retinal_apoptosis0.71612219
161MP0000358_abnormal_cell_content/0.70625178
162MP0003866_abnormal_defecation0.69676817
163MP0000470_abnormal_stomach_morphology0.69303591
164MP0005501_abnormal_skin_physiology0.66693822
165MP0009115_abnormal_fat_cell0.66552204
166MP0000685_abnormal_immune_system0.63480729
167MP0003936_abnormal_reproductive_system0.63449743
168MP0005310_abnormal_salivary_gland0.62153957
169MP0001119_abnormal_female_reproductive0.61688105
170MP0000371_diluted_coat_color0.57645823
171MP0003221_abnormal_cardiomyocyte_apopto0.57427892
172MP0000477_abnormal_intestine_morphology0.57150366
173MP0005365_abnormal_bile_salt0.56975407
174MP0000015_abnormal_ear_pigmentation0.55401305
175MP0004133_heterotaxia0.53751713
176MP0001661_extended_life_span0.52813928
177MP0000627_abnormal_mammary_gland0.50469558
178MP0001324_abnormal_eye_pigmentation0.49257407
179MP0002111_abnormal_tail_morphology0.48483421
180MP0002006_tumorigenesis0.48381700

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.25695981
2Dynein arm defect of respiratory motile cilia (HP:0012255)8.15774426
3Absent/shortened dynein arms (HP:0200106)8.15774426
4Abnormal respiratory epithelium morphology (HP:0012253)7.15744345
5Abnormal respiratory motile cilium morphology (HP:0005938)7.15744345
6Male infertility (HP:0003251)6.29005555
7Infertility (HP:0000789)5.55197608
8Abnormal respiratory motile cilium physiology (HP:0012261)5.52591000
9Chronic bronchitis (HP:0004469)4.80473833
10Rhinitis (HP:0012384)4.72007770
11Pustule (HP:0200039)4.31362803
12Congenital stationary night blindness (HP:0007642)4.23598606
13Nasal polyposis (HP:0100582)4.22234435
14Abnormal ciliary motility (HP:0012262)4.19945387
15Impulsivity (HP:0100710)4.11971752
16Abnormality of midbrain morphology (HP:0002418)3.80906039
17Molar tooth sign on MRI (HP:0002419)3.80906039
18Pancreatic cysts (HP:0001737)3.74604396
19Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.61442484
20Alopecia of scalp (HP:0002293)3.50905525
21Tongue fasciculations (HP:0001308)3.46607705
22Abnormal spermatogenesis (HP:0008669)3.37759842
23Facial hemangioma (HP:0000329)3.37375013
24Attenuation of retinal blood vessels (HP:0007843)3.32945718
25Pancreatic fibrosis (HP:0100732)3.32317289
26Abnormality of the nasal mucosa (HP:0000433)3.31679968
27True hermaphroditism (HP:0010459)3.24775970
28Aplasia/hypoplasia of the humerus (HP:0006507)3.21184602
29Concave nail (HP:0001598)3.20682962
30Muscle fibrillation (HP:0010546)3.19414411
31Abnormality of the renal cortex (HP:0011035)3.14306273
32Short humerus (HP:0005792)3.12242547
33Bronchiectasis (HP:0002110)3.10391463
34Abnormality of the renal medulla (HP:0100957)2.98615988
35Breast hypoplasia (HP:0003187)2.97178784
36Bronchitis (HP:0012387)2.91192294
37Polydipsia (HP:0001959)2.86883288
38Abnormal drinking behavior (HP:0030082)2.86883288
39Poikiloderma (HP:0001029)2.82838739
40Chronic hepatic failure (HP:0100626)2.82044377
41Hyperventilation (HP:0002883)2.78657996
42Absent radius (HP:0003974)2.78460754
43Pendular nystagmus (HP:0012043)2.76799301
44Decreased circulating renin level (HP:0003351)2.75587999
45Abolished electroretinogram (ERG) (HP:0000550)2.73238608
46Abnormal rod and cone electroretinograms (HP:0008323)2.68434614
47Tubular atrophy (HP:0000092)2.60006287
48Aplasia involving forearm bones (HP:0009822)2.58558614
49Absent forearm bone (HP:0003953)2.58558614
50Medial flaring of the eyebrow (HP:0010747)2.54808329
51Large for gestational age (HP:0001520)2.52777596
52Abnormality of glutamine family amino acid metabolism (HP:0010902)2.48400998
53Dysautonomia (HP:0002459)2.44911967
54Type 2 muscle fiber atrophy (HP:0003554)2.44731060
55Type II lissencephaly (HP:0007260)2.44664947
56Renal cortical cysts (HP:0000803)2.43356249
57Stomatitis (HP:0010280)2.43305546
58Rib fusion (HP:0000902)2.42900807
59Absent thumb (HP:0009777)2.42600570
60Stomach cancer (HP:0012126)2.42341336
61Patellar aplasia (HP:0006443)2.40959041
62Recurrent otitis media (HP:0000403)2.40760855
63Inability to walk (HP:0002540)2.40484053
64Aplasia/Hypoplasia of the patella (HP:0006498)2.39648004
65Congenital sensorineural hearing impairment (HP:0008527)2.37483844
66Squamous cell carcinoma (HP:0002860)2.36198774
67Decreased central vision (HP:0007663)2.36001352
68Hypoplasia of the radius (HP:0002984)2.33428656
69Polyuria (HP:0000103)2.32727995
70Bundle branch block (HP:0011710)2.31923383
71Rectal fistula (HP:0100590)2.31605015
72Rectovaginal fistula (HP:0000143)2.31605015
73Abnormality of macular pigmentation (HP:0008002)2.31364725
74Muscle fiber atrophy (HP:0100295)2.30008422
75Abnormality of vitamin B metabolism (HP:0004340)2.27122384
76Progressive inability to walk (HP:0002505)2.26194383
77Decreased electroretinogram (ERG) amplitude (HP:0000654)2.24619693
78Glycosuria (HP:0003076)2.23061682
79Abnormality of urine glucose concentration (HP:0011016)2.23061682
80Ketoacidosis (HP:0001993)2.22809383
81Increased IgM level (HP:0003496)2.22349750
82Carpal bone hypoplasia (HP:0001498)2.22032168
83Cystic liver disease (HP:0006706)2.20979119
84Abnormality of alanine metabolism (HP:0010916)2.18700421
85Hyperalaninemia (HP:0003348)2.18700421
86Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.18700421
87Hypomagnesemia (HP:0002917)2.17824670
88Abnormality of male internal genitalia (HP:0000022)2.16998634
89Metabolic alkalosis (HP:0200114)2.16690331
90Progressive cerebellar ataxia (HP:0002073)2.16391503
91Hyperglycinemia (HP:0002154)2.16029000
92Azoospermia (HP:0000027)2.15753961
93Abnormal urine output (HP:0012590)2.14194597
94Selective tooth agenesis (HP:0001592)2.13371055
95Cerebral hypomyelination (HP:0006808)2.13011645
96Degeneration of anterior horn cells (HP:0002398)2.10035376
97Abnormality of the anterior horn cell (HP:0006802)2.10035376
98Congenital, generalized hypertrichosis (HP:0004540)2.09523573
99Ketosis (HP:0001946)2.08775352
100Annular pancreas (HP:0001734)2.08111164
101Recurrent sinusitis (HP:0011108)2.08016320
102Abnormality of the vitamin B12 metabolism (HP:0004341)2.07471805
103Rough bone trabeculation (HP:0100670)2.06651545
104Abnormality of renin-angiotensin system (HP:0000847)2.06489897
105Bony spicule pigmentary retinopathy (HP:0007737)2.06398996
106Abnormality of proline metabolism (HP:0010907)2.05653698
107Hydroxyprolinuria (HP:0003080)2.05653698
108Hypothermia (HP:0002045)2.05179518
1093-Methylglutaconic aciduria (HP:0003535)2.04187680
110Genetic anticipation (HP:0003743)2.03458902
111Gaze-evoked nystagmus (HP:0000640)2.02906445
112Hypoproteinemia (HP:0003075)2.02224524
113Sclerocornea (HP:0000647)2.01857480
114Ureteral duplication (HP:0000073)2.00321488
115Premature ovarian failure (HP:0008209)1.98790546
116Hypoalbuminemia (HP:0003073)1.97927536
117Abnormal albumin level (HP:0012116)1.97927536
118Methylmalonic aciduria (HP:0012120)1.97854282
119Birth length less than 3rd percentile (HP:0003561)1.97219960
120Increased CSF lactate (HP:0002490)1.96445602
121Abnormality of renal excretion (HP:0011036)1.96301715
122Mitochondrial inheritance (HP:0001427)1.95982411
123Abnormality of the umbilical cord (HP:0010881)1.95616979
124Capillary hemangiomas (HP:0005306)1.94779675
125Vaginal fistula (HP:0004320)1.94541259
126Chorioretinal atrophy (HP:0000533)1.94118363
127Keratoconus (HP:0000563)1.93549625
128Increased corneal curvature (HP:0100692)1.93549625
129Intestinal fistula (HP:0100819)1.93290870
130Furrowed tongue (HP:0000221)1.93074788
131Chronic diarrhea (HP:0002028)1.93032573
132Tetany (HP:0001281)1.92017955
133Gait imbalance (HP:0002141)1.91372817
134Hyperglycinuria (HP:0003108)1.90924001
135Polycythemia (HP:0001901)1.90509799
136Ulnar bowing (HP:0003031)1.90328371
137Optic disc pallor (HP:0000543)1.90247471
138Aplasia of the musculature (HP:0100854)1.88994269
139Alkalosis (HP:0001948)1.88821222
140Abnormality of glycine metabolism (HP:0010895)1.88627051
141Abnormality of serine family amino acid metabolism (HP:0010894)1.88627051
142Congenital primary aphakia (HP:0007707)1.87994201
143Progressive muscle weakness (HP:0003323)1.87066256
144Acute encephalopathy (HP:0006846)1.86302773
145Median cleft lip (HP:0000161)1.84756792
146Difficulty climbing stairs (HP:0003551)1.84290597
147Aplasia/Hypoplasia of the fovea (HP:0008060)1.83995904
148Hypoplasia of the fovea (HP:0007750)1.83995904
149Severe visual impairment (HP:0001141)1.83931082
150Aplasia/Hypoplasia involving the musculature (HP:0001460)1.83883100
151Acute necrotizing encephalopathy (HP:0006965)1.83712744
152Abnormal biliary tract physiology (HP:0012439)1.83284606
153Bile duct proliferation (HP:0001408)1.83284606
154Congenital hepatic fibrosis (HP:0002612)1.82370078
155Personality changes (HP:0000751)1.80711016
156Hypoplasia of the capital femoral epiphysis (HP:0003090)1.78838772
157Male pseudohermaphroditism (HP:0000037)1.77452898
158Lipid accumulation in hepatocytes (HP:0006561)1.76946377
159Death in infancy (HP:0001522)1.76431981
160Glucose intolerance (HP:0000833)1.75951014
161Abnormality of the aortic arch (HP:0012303)1.75452293
162Abnormality of the ileum (HP:0001549)1.73862961
163Abnormality of magnesium homeostasis (HP:0004921)1.73157469
164IgG deficiency (HP:0004315)1.72509552
165Tachypnea (HP:0002789)1.72240261
166Anencephaly (HP:0002323)1.72026235
167Methylmalonic acidemia (HP:0002912)1.72003547
168Elevated erythrocyte sedimentation rate (HP:0003565)1.71919998
169Aplasia/Hypoplasia of the spleen (HP:0010451)1.71905001
170Nephronophthisis (HP:0000090)1.68564558
171Spinal muscular atrophy (HP:0007269)1.67153414
172Sparse lateral eyebrow (HP:0005338)1.65886099
173Short thumb (HP:0009778)1.65758104
174Albinism (HP:0001022)1.65602325
175Recurrent bronchitis (HP:0002837)1.65004601
176Cheilitis (HP:0100825)1.63740597
177Short chin (HP:0000331)1.61960906
178Spastic tetraparesis (HP:0001285)1.59631852
179Gonadotropin excess (HP:0000837)1.58616744
180Bulbar palsy (HP:0001283)1.58442506
181Aplasia/Hypoplasia of the ulna (HP:0006495)1.57220008
182Abnormal hemoglobin (HP:0011902)1.56159137
183Easy fatigability (HP:0003388)1.55336040
184Abnormality of lateral ventricle (HP:0030047)1.54686857
185Abnormality of the neuromuscular junction (HP:0003398)1.52603272
186Fatigable weakness (HP:0003473)1.52603272
187Premature graying of hair (HP:0002216)1.51818153
188Absent hand (HP:0004050)1.50521705
189Ventricular fibrillation (HP:0001663)1.50097278
190Asymmetric septal hypertrophy (HP:0001670)1.49661042
191Malnutrition (HP:0004395)1.49449073
192Abnormality of the labia minora (HP:0012880)1.49425725

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK45.94217884
2PDK35.94217884
3FRK5.29805700
4ICK5.17186050
5PDK24.00832030
6ADRBK23.48728717
7AKT32.96074871
8BUB12.90561000
9BMPR1B2.89727581
10PINK12.88096472
11MAPK152.80268000
12DDR22.71375551
13TESK12.66348824
14MAP4K22.54333755
15GRK12.54065177
16WEE12.47899146
17INSRR2.45203183
18WNK32.35151503
19NEK22.28792546
20TAOK32.21083593
21TLK12.14338745
22MAP3K62.07668960
23OXSR12.05918426
24NUAK12.00649004
25DYRK1B1.91296900
26DYRK31.91292299
27TXK1.91028261
28EPHA21.72039343
29PIM21.69198290
30MAP3K111.68894678
31CASK1.67211077
32TYRO31.65814343
33PRKD31.59043160
34MAPK131.56362037
35MATK1.54262969
36CHEK21.41153984
37PLK11.35373356
38BRSK21.29279633
39MAP3K41.28817046
40PTK2B1.24949606
41DAPK21.24637991
42CDK71.22442434
43PLK41.20061228
44ITK1.19657416
45TNIK1.19338367
46STK31.19215785
47EIF2AK11.17747875
48CAMKK21.14641153
49TTK1.13479039
50PIM11.10392564
51FGR1.10379032
52PIK3CA1.07070615
53PAK31.04541489
54CSK1.02302356
55YES11.01521854
56PRKCE0.99196196
57TAF10.95247798
58STK380.94600980
59ADRBK10.94542315
60TRIM280.94017677
61IRAK40.89839684
62EPHA30.88952152
63IRAK10.88568731
64DAPK10.86710253
65IKBKB0.86045196
66GRK70.85811805
67STK38L0.85756434
68TIE10.85681193
69IKBKE0.83127921
70LATS20.81512563
71VRK10.79884342
72CDK60.79095848
73TGFBR10.75868109
74PRKCG0.74684517
75BCR0.74250593
76BMX0.74100687
77TESK20.73856910
78AURKB0.73167180
79MAPKAPK30.70825216
80TEC0.69888840
81MAPKAPK50.69405564
82KIT0.69097773
83PRKAA10.68358345
84PRKD20.67840557
85JAK30.65717368
86BRSK10.65273411
87PRKCQ0.64571541
88PNCK0.63995368
89NME20.63719473
90ATR0.63567379
91CSNK1G10.62810920
92PAK10.62250996
93CHEK10.62229536
94FER0.60377769
95AURKA0.59321885
96BCKDK0.58619774
97CSNK1G20.58554936
98CCNB10.57880937
99MKNK10.57067690
100SRPK10.56794772
101MAP4K10.55183576
102NEK10.54689667
103CHUK0.54684262
104CSNK1G30.54418887
105MTOR0.54070633
106ACVR1B0.53951171
107ERBB30.53637879
108MUSK0.53394745
109PRKCZ0.52818595
110PDGFRA0.52747131
111CSNK1A10.52446434
112MAP2K70.52130840
113NLK0.51486311
114GSK3A0.51403690
115RPS6KA50.50390141
116CSNK2A10.50119307
117TSSK60.49946436
118PHKG10.49616508
119PHKG20.49616508
120PLK20.49538218
121CSNK1A1L0.48872526
122MAP3K120.48723204
123CDK40.47641748
124CAMK2A0.47413647
125EIF2AK30.46430363
126MAPK110.46404425
127STK390.46050415
128RPS6KC10.45391811
129RPS6KL10.45391811
130CDK20.45337484
131RPS6KB20.44635613
132RPS6KA10.44538552
133PRKACA0.44014939
134NTRK30.42783067
135PRKCI0.42646941
136PRKCA0.42262533
137FGFR20.42213037
138CDC70.42105790
139IGF1R0.40624346
140STK160.40334628
141PRKG20.40219055
142SYK0.40150307
143MKNK20.39774921
144UHMK10.39743667
145TRPM70.38248818
146PDK10.37882915
147LATS10.37768296
148PIK3CG0.37711626
149RPS6KA60.36732027
150NME10.36559391
151CSNK2A20.36553353
152ATM0.35055198
153LYN0.33988125
154MAP2K20.33859474
155PLK30.33357542
156MARK10.33213613
157MAP3K100.31953039
158PRKG10.31113394
159MAP2K60.29326744
160MST40.28980839
161MAP3K80.28257766
162LMTK20.28041581
163PRKACG0.27778351
164TYK20.27025413
165PKN10.26134651
166ZAK0.25824985
167CDC42BPA0.24495361
168CDK10.24123391
169ALK0.21822218
170PAK20.21540082
171RPS6KB10.21219998
172PAK40.19919471
173WNK40.18435680
174STK100.17126720
175PRKAA20.17061864
176CSNK1E0.16462806
177DYRK20.16399573
178CAMK2G0.16385920

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.99479652
2Fatty acid biosynthesis_Homo sapiens_hsa000614.03843412
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.36996294
4Base excision repair_Homo sapiens_hsa034103.11926410
5Mismatch repair_Homo sapiens_hsa034303.09590261
6DNA replication_Homo sapiens_hsa030303.02837540
7RNA transport_Homo sapiens_hsa030132.98734514
8Proteasome_Homo sapiens_hsa030502.43025423
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.37250331
10Nitrogen metabolism_Homo sapiens_hsa009102.24562103
11Caffeine metabolism_Homo sapiens_hsa002322.22216598
12RNA polymerase_Homo sapiens_hsa030202.21490467
13Phototransduction_Homo sapiens_hsa047442.19936385
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.17181525
15Basal transcription factors_Homo sapiens_hsa030222.16115641
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.14555010
17Tryptophan metabolism_Homo sapiens_hsa003802.13535995
18Butanoate metabolism_Homo sapiens_hsa006502.09592803
19Spliceosome_Homo sapiens_hsa030402.07833183
20Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.07101540
21Fructose and mannose metabolism_Homo sapiens_hsa000511.99735164
22Fanconi anemia pathway_Homo sapiens_hsa034601.98293982
23Nucleotide excision repair_Homo sapiens_hsa034201.95791053
24Graft-versus-host disease_Homo sapiens_hsa053321.88433208
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.88084792
26Cell cycle_Homo sapiens_hsa041101.87752192
27Asthma_Homo sapiens_hsa053101.86704217
28Homologous recombination_Homo sapiens_hsa034401.83800372
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.76853479
30Oxidative phosphorylation_Homo sapiens_hsa001901.73919789
31mRNA surveillance pathway_Homo sapiens_hsa030151.72215484
32Allograft rejection_Homo sapiens_hsa053301.70301106
33Pyrimidine metabolism_Homo sapiens_hsa002401.67406348
34Glycerophospholipid metabolism_Homo sapiens_hsa005641.67129329
35Sulfur metabolism_Homo sapiens_hsa009201.66621571
36p53 signaling pathway_Homo sapiens_hsa041151.62631656
37Folate biosynthesis_Homo sapiens_hsa007901.60844550
38Oocyte meiosis_Homo sapiens_hsa041141.58915802
39Pentose phosphate pathway_Homo sapiens_hsa000301.58382934
40Autoimmune thyroid disease_Homo sapiens_hsa053201.57131023
41Type I diabetes mellitus_Homo sapiens_hsa049401.57018486
42Chemical carcinogenesis_Homo sapiens_hsa052041.55651593
43Linoleic acid metabolism_Homo sapiens_hsa005911.55334178
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.53145309
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.50467525
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.48226066
47Biosynthesis of amino acids_Homo sapiens_hsa012301.46235166
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.41598175
49Sulfur relay system_Homo sapiens_hsa041221.32522552
50Retinol metabolism_Homo sapiens_hsa008301.31454626
51Mineral absorption_Homo sapiens_hsa049781.28996621
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28146090
53Nicotine addiction_Homo sapiens_hsa050331.23647255
54Primary bile acid biosynthesis_Homo sapiens_hsa001201.22531092
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.20685300
56Purine metabolism_Homo sapiens_hsa002301.19263780
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.17021415
58Histidine metabolism_Homo sapiens_hsa003401.15161767
59Parkinsons disease_Homo sapiens_hsa050121.15037031
60Ribosome_Homo sapiens_hsa030101.13830203
61Cysteine and methionine metabolism_Homo sapiens_hsa002701.13519978
62Glutathione metabolism_Homo sapiens_hsa004801.13429487
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12770617
64Selenocompound metabolism_Homo sapiens_hsa004501.11034803
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09772361
66Hedgehog signaling pathway_Homo sapiens_hsa043401.09696217
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.08985417
68Circadian rhythm_Homo sapiens_hsa047101.07402437
69Glycerolipid metabolism_Homo sapiens_hsa005611.07116861
70Protein export_Homo sapiens_hsa030601.06807784
71Peroxisome_Homo sapiens_hsa041461.06612388
72Vitamin digestion and absorption_Homo sapiens_hsa049771.06578124
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03738705
74Fat digestion and absorption_Homo sapiens_hsa049751.01805787
75Arginine and proline metabolism_Homo sapiens_hsa003300.96170292
76Taste transduction_Homo sapiens_hsa047420.95394316
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93591837
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92345809
79Regulation of autophagy_Homo sapiens_hsa041400.90149407
80Olfactory transduction_Homo sapiens_hsa047400.89364443
81Antigen processing and presentation_Homo sapiens_hsa046120.88378124
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87714297
83Epstein-Barr virus infection_Homo sapiens_hsa051690.87311762
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86589913
85ABC transporters_Homo sapiens_hsa020100.85376537
86Renin-angiotensin system_Homo sapiens_hsa046140.81310109
87mTOR signaling pathway_Homo sapiens_hsa041500.81224483
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81097258
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79450530
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78801223
91Fatty acid metabolism_Homo sapiens_hsa012120.78221977
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77407986
93Fatty acid degradation_Homo sapiens_hsa000710.77347050
94Hippo signaling pathway_Homo sapiens_hsa043900.77096778
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76951060
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.74478581
97Arachidonic acid metabolism_Homo sapiens_hsa005900.72996957
98Pyruvate metabolism_Homo sapiens_hsa006200.72505646
99Carbon metabolism_Homo sapiens_hsa012000.69550789
100Alzheimers disease_Homo sapiens_hsa050100.69328027
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68796740
102Serotonergic synapse_Homo sapiens_hsa047260.67521348
103Cardiac muscle contraction_Homo sapiens_hsa042600.67268853
104Legionellosis_Homo sapiens_hsa051340.66169067
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65438673
106RNA degradation_Homo sapiens_hsa030180.64623100
107Insulin secretion_Homo sapiens_hsa049110.64406502
108Arginine biosynthesis_Homo sapiens_hsa002200.63623451
109Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62483765
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62463493
111Rheumatoid arthritis_Homo sapiens_hsa053230.62120339
112beta-Alanine metabolism_Homo sapiens_hsa004100.61032038
113Starch and sucrose metabolism_Homo sapiens_hsa005000.60860525
114Morphine addiction_Homo sapiens_hsa050320.60658542
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58276576
116Protein digestion and absorption_Homo sapiens_hsa049740.57152511
117Dorso-ventral axis formation_Homo sapiens_hsa043200.54977615
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53801646
119Collecting duct acid secretion_Homo sapiens_hsa049660.52916421
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51959788
121Ovarian steroidogenesis_Homo sapiens_hsa049130.51427769
122Salivary secretion_Homo sapiens_hsa049700.50782619
123Tight junction_Homo sapiens_hsa045300.49676007
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.49233828
125Adherens junction_Homo sapiens_hsa045200.47403235
126Metabolic pathways_Homo sapiens_hsa011000.45539820
127Pancreatic secretion_Homo sapiens_hsa049720.44760643
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44759353
129Glucagon signaling pathway_Homo sapiens_hsa049220.44210467
130Viral carcinogenesis_Homo sapiens_hsa052030.43458731
131Galactose metabolism_Homo sapiens_hsa000520.43189891
132Cyanoamino acid metabolism_Homo sapiens_hsa004600.41700394
133Fatty acid elongation_Homo sapiens_hsa000620.40366575
134Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40314549
135Herpes simplex infection_Homo sapiens_hsa051680.39735126
136Staphylococcus aureus infection_Homo sapiens_hsa051500.39711280
137Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39040283
138Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37289976
139Propanoate metabolism_Homo sapiens_hsa006400.36116185
140Maturity onset diabetes of the young_Homo sapiens_hsa049500.36097733
141Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.35954186
142African trypanosomiasis_Homo sapiens_hsa051430.35760037
143Circadian entrainment_Homo sapiens_hsa047130.35757464
1442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.35168683
145Shigellosis_Homo sapiens_hsa051310.34453312
146AMPK signaling pathway_Homo sapiens_hsa041520.33633775
147Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31746481
148Primary immunodeficiency_Homo sapiens_hsa053400.31165413
149Notch signaling pathway_Homo sapiens_hsa043300.30896026
150Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30347412
151Ether lipid metabolism_Homo sapiens_hsa005650.27633618
152Small cell lung cancer_Homo sapiens_hsa052220.26655718
153VEGF signaling pathway_Homo sapiens_hsa043700.24209477
154Wnt signaling pathway_Homo sapiens_hsa043100.23642570
155Huntingtons disease_Homo sapiens_hsa050160.22015707
156Basal cell carcinoma_Homo sapiens_hsa052170.20616306
157PPAR signaling pathway_Homo sapiens_hsa033200.17955487
158Intestinal immune network for IgA production_Homo sapiens_hsa046720.17817365
159Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.17289530
160Endocytosis_Homo sapiens_hsa041440.16538959

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