BCL2L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)4.84200776
2synaptic vesicle maturation (GO:0016188)4.79332748
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.49630873
4locomotory exploration behavior (GO:0035641)4.49336370
5glutamate secretion (GO:0014047)4.04618020
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.94337388
7regulation of synaptic vesicle exocytosis (GO:2000300)3.93908148
8synaptic vesicle exocytosis (GO:0016079)3.91924298
9synaptic vesicle docking involved in exocytosis (GO:0016081)3.89542727
10sodium ion export (GO:0071436)3.85772449
11cerebellar granule cell differentiation (GO:0021707)3.84983610
12vocalization behavior (GO:0071625)3.84791723
13cellular potassium ion homeostasis (GO:0030007)3.82011394
14cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.65590730
15amino acid import (GO:0043090)3.57899563
16layer formation in cerebral cortex (GO:0021819)3.54282620
17neuronal action potential propagation (GO:0019227)3.52911020
18neurotransmitter secretion (GO:0007269)3.51577585
19activation of protein kinase A activity (GO:0034199)3.48616225
20regulation of synaptic vesicle transport (GO:1902803)3.48606692
21regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.40091488
22regulation of glutamate receptor signaling pathway (GO:1900449)3.32844933
23regulation of synapse structural plasticity (GO:0051823)3.32161992
24proline transport (GO:0015824)3.29779914
25cell communication by electrical coupling (GO:0010644)3.25362986
26membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.22669710
27regulation of neuronal synaptic plasticity (GO:0048168)3.19801699
28gamma-aminobutyric acid transport (GO:0015812)3.17449807
29negative regulation of dendrite morphogenesis (GO:0050774)3.16026898
30exploration behavior (GO:0035640)3.12668776
31glycine transport (GO:0015816)3.10377101
32regulation of long-term neuronal synaptic plasticity (GO:0048169)3.09095408
33potassium ion import (GO:0010107)3.07098076
34positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.04371131
35ionotropic glutamate receptor signaling pathway (GO:0035235)3.02531167
36protein localization to synapse (GO:0035418)2.93319154
37negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.92377652
38regulation of ARF protein signal transduction (GO:0032012)2.90881446
39neuromuscular process controlling balance (GO:0050885)2.90458215
40regulation of synapse maturation (GO:0090128)2.88002347
41potassium ion homeostasis (GO:0055075)2.87477809
42regulation of early endosome to late endosome transport (GO:2000641)2.86093180
43cytoskeletal anchoring at plasma membrane (GO:0007016)2.83963616
44neurotransmitter transport (GO:0006836)2.83642713
45dendritic spine morphogenesis (GO:0060997)2.82471025
46axon ensheathment in central nervous system (GO:0032291)2.81216102
47central nervous system myelination (GO:0022010)2.81216102
48neuromuscular process controlling posture (GO:0050884)2.78357001
49cell communication involved in cardiac conduction (GO:0086065)2.78274629
50long-term memory (GO:0007616)2.77971297
51G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.77646328
52synaptic transmission, glutamatergic (GO:0035249)2.77383377
53regulation of clathrin-mediated endocytosis (GO:2000369)2.75317393
54cerebellar Purkinje cell differentiation (GO:0021702)2.73874351
55positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.73588760
56vesicle transport along microtubule (GO:0047496)2.72767071
57positive regulation of dendritic spine development (GO:0060999)2.72410720
58cellular sodium ion homeostasis (GO:0006883)2.70783438
59mating behavior (GO:0007617)2.69705105
60regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.68715555
61positive regulation of neurotransmitter secretion (GO:0001956)2.68080266
62neuron-neuron synaptic transmission (GO:0007270)2.67276662
63regulation of excitatory postsynaptic membrane potential (GO:0060079)2.64570011
64protein localization to endosome (GO:0036010)2.63394386
65regulation of neurotransmitter levels (GO:0001505)2.61950830
66membrane repolarization (GO:0086009)2.61939617
67neurotransmitter-gated ion channel clustering (GO:0072578)2.61789223
68glutamate receptor signaling pathway (GO:0007215)2.61569492
69membrane depolarization during action potential (GO:0086010)2.60766638
70dendrite morphogenesis (GO:0048813)2.60306947
71protein retention in ER lumen (GO:0006621)2.58577989
72regulation of dendritic spine morphogenesis (GO:0061001)2.57248906
73suckling behavior (GO:0001967)2.56778806
74positive regulation of potassium ion transport (GO:0043268)2.56731101
75regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.56213726
76desmosome organization (GO:0002934)2.54951003
77cerebellar Purkinje cell layer development (GO:0021680)2.54945774
78alanine transport (GO:0032328)2.54854862
79synaptic vesicle endocytosis (GO:0048488)2.54638497
80positive regulation of membrane potential (GO:0045838)2.54597663
81protein targeting to Golgi (GO:0000042)2.52436486
82membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.52433165
83neuronal ion channel clustering (GO:0045161)2.52229907
84regulation of postsynaptic membrane potential (GO:0060078)2.52130881
85positive regulation of neurotransmitter transport (GO:0051590)2.51838365
86regulation of neurotransmitter secretion (GO:0046928)2.51562191
87myelin maintenance (GO:0043217)2.50815202
88regulation of synaptic plasticity (GO:0048167)2.50558209
89focal adhesion assembly (GO:0048041)2.49450060
90cell-substrate adherens junction assembly (GO:0007045)2.49450060
91adherens junction assembly (GO:0034333)2.48973534
92positive regulation of potassium ion transmembrane transport (GO:1901381)2.48730288
93regulation of vesicle fusion (GO:0031338)2.47033411
94detection of calcium ion (GO:0005513)2.46360864
95cell-substrate junction assembly (GO:0007044)2.46066196
96plasma membrane repair (GO:0001778)2.45143695
97prepulse inhibition (GO:0060134)2.44907621
98maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.43870126
99neuron recognition (GO:0008038)2.41337650
100chemosensory behavior (GO:0007635)2.41233758
101positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.40044766
102regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.39737748
103neuron cell-cell adhesion (GO:0007158)2.38596100
104regulation of voltage-gated calcium channel activity (GO:1901385)2.38512805
105regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.37878262
106positive regulation of dendritic spine morphogenesis (GO:0061003)2.36553637
107positive regulation of synapse maturation (GO:0090129)2.36234092
108establishment of protein localization to Golgi (GO:0072600)2.35424368
109transmission of nerve impulse (GO:0019226)2.34510430
110innervation (GO:0060384)2.34334671
111regulation of calcium ion transmembrane transport (GO:1903169)2.33944300
112regulation of calcium ion transmembrane transporter activity (GO:1901019)2.33944300
113regulation of neurotransmitter transport (GO:0051588)2.33638556
114L-amino acid import (GO:0043092)2.33575447
115membrane hyperpolarization (GO:0060081)2.33527158
116regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.33256542
117membrane depolarization (GO:0051899)2.31860538
118establishment of nucleus localization (GO:0040023)2.31622667
119organelle transport along microtubule (GO:0072384)2.31043229
120long term synaptic depression (GO:0060292)2.29978408
121protein targeting to plasma membrane (GO:0072661)2.29663362
122positive regulation of synaptic transmission, GABAergic (GO:0032230)2.29459003
123positive regulation of glucose transport (GO:0010828)2.26182160
124cell volume homeostasis (GO:0006884)2.24390325
125positive regulation of glucose import (GO:0046326)2.23601557
126phosphate ion transmembrane transport (GO:0035435)2.23450756
127stress fiber assembly (GO:0043149)2.21262530
128positive regulation of dendrite development (GO:1900006)2.21042094
129regulation of cholesterol homeostasis (GO:2000188)2.20775031
130hemidesmosome assembly (GO:0031581)2.19441775
131dendritic spine organization (GO:0097061)2.17947895
132vesicle docking involved in exocytosis (GO:0006904)2.14489862
133dopamine receptor signaling pathway (GO:0007212)2.13926862
134gamma-aminobutyric acid signaling pathway (GO:0007214)2.13596770
135negative regulation of synaptic transmission, GABAergic (GO:0032229)2.13058428
136cortical actin cytoskeleton organization (GO:0030866)2.12653646
137cellular response to monoamine stimulus (GO:0071868)2.11523072
138cellular response to catecholamine stimulus (GO:0071870)2.11523072
139endocytic recycling (GO:0032456)2.10320653
140dicarboxylic acid transport (GO:0006835)2.10120850
141dicarboxylic acid biosynthetic process (GO:0043650)2.09765345
142skin morphogenesis (GO:0043589)2.09023172

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.12341415
2TP63_17297297_ChIP-ChIP_HaCaT_Human2.94305602
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.65009052
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.60518197
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.52878662
6DROSHA_22980978_ChIP-Seq_HELA_Human2.42509535
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.36001563
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.36001563
9MTF2_20144788_ChIP-Seq_MESCs_Mouse2.32417008
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.28384553
11SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24731603
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.18056163
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.15999122
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.14941540
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.13702110
16GBX2_23144817_ChIP-Seq_PC3_Human2.09156850
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.99284621
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.98805821
19REST_21632747_ChIP-Seq_MESCs_Mouse1.93320359
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.89799303
21EZH2_27294783_Chip-Seq_ESCs_Mouse1.89303769
22SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88773981
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.87245648
24CLOCK_20551151_ChIP-Seq_293T_Human1.86114792
25EZH2_27304074_Chip-Seq_ESCs_Mouse1.80510484
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.78620280
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78129899
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.73618121
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.73557777
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.65007265
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.63452331
32ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.62415667
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57358520
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53912777
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52136520
36ESR1_21235772_ChIP-Seq_MCF-7_Human1.51379966
37RACK7_27058665_Chip-Seq_MCF-7_Human1.50290737
38KDM2B_26808549_Chip-Seq_K562_Human1.42560049
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.38081768
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37841644
41ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.36274049
42* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.35982518
43SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.35171822
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34933242
45AR_21572438_ChIP-Seq_LNCaP_Human1.34343299
46RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.33819869
47NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33590836
48WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.33382526
49UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33143494
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32719862
51SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31768464
52ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.30218542
53EP300_21415370_ChIP-Seq_HL-1_Mouse1.29969358
54ESR1_20079471_ChIP-ChIP_T-47D_Human1.26192402
55ELK3_25401928_ChIP-Seq_HUVEC_Human1.23375645
56SMAD4_21799915_ChIP-Seq_A2780_Human1.22842584
57EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.22561853
58SMC4_20622854_ChIP-Seq_HELA_Human1.21501797
59DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21378716
60* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.19918744
61ZNF274_21170338_ChIP-Seq_K562_Hela1.19796806
62TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19483491
63NFIB_24661679_ChIP-Seq_LUNG_Mouse1.19391672
64AHR_22903824_ChIP-Seq_MCF-7_Human1.17946732
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.17438921
66SOX9_24532713_ChIP-Seq_HFSC_Mouse1.17055122
67P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16638968
68ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.16166167
69BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15866666
70CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15787447
71TBX20_22080862_ChIP-Seq_HEART_Mouse1.14831818
72TBX20_22328084_ChIP-Seq_HEART_Mouse1.14831818
73CREB1_26743006_Chip-Seq_LNCaP_Human1.13971221
74RING1B_27294783_Chip-Seq_ESCs_Mouse1.13321001
75AR_19668381_ChIP-Seq_PC3_Human1.13013216
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.12403324
77KDM2B_26808549_Chip-Seq_DND41_Human1.10428613
78TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.09280044
79CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09181991
80SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09005084
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08879048
82KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08328736
83TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07471397
84ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07281191
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.07004957
86PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06289718
87GATA2_21666600_ChIP-Seq_HMVEC_Human1.06050095
88NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05735163
89SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05474800
90GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05114354
91PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04994707
92TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04993218
93KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03852613
94CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03272039
95TRIM28_21343339_ChIP-Seq_HEK293_Human1.02434107
96NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.01697567
97RXR_22158963_ChIP-Seq_LIVER_Mouse1.01341546
98TCF7_22412390_ChIP-Seq_EML_Mouse1.00739114
99TP53_23651856_ChIP-Seq_MEFs_Mouse1.00672880
100RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99759169
101SMAD4_21741376_ChIP-Seq_HESCs_Human0.98751909
102STAT3_23295773_ChIP-Seq_U87_Human0.98657293
103RXR_22108803_ChIP-Seq_LS180_Human0.98522066
104GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.97321311
105SMAD3_21741376_ChIP-Seq_HESCs_Human0.97303281
106SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96288153
107THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96006874
108KDM2B_26808549_Chip-Seq_JURKAT_Human0.95256311
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95155950
110SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94512746
111FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.94479894
112RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94428720
113OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.93217370
114FOXA2_19822575_ChIP-Seq_HepG2_Human0.92861841
115CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92729692
116TP53_16413492_ChIP-PET_HCT116_Human0.92455252
117AR_25329375_ChIP-Seq_VCAP_Human0.92029683
118KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91625389
119DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91581416
120RING1B_27294783_Chip-Seq_NPCs_Mouse0.91552254
121CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90932979
122KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90702890
123RUNX1_27514584_Chip-Seq_MCF-7_Human0.90644903
124ZNF263_19887448_ChIP-Seq_K562_Human0.89915571
125ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89102658
126YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88974266
127TET1_21490601_ChIP-Seq_MESCs_Mouse0.88877836
128SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86950812
129BCAT_22108803_ChIP-Seq_LS180_Human0.86833139
130NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86583718
131NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86583718
132CTCF_27219007_Chip-Seq_Bcells_Human0.86357167
133PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.86110634
134OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84942696
135NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84418800
136RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.83976482
137SMAD3_21741376_ChIP-Seq_EPCs_Human0.83131907
138* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.82817473
139LXR_22292898_ChIP-Seq_THP-1_Human0.82229257
140SMAD3_21741376_ChIP-Seq_ESCs_Human0.82161841
141ZFP281_27345836_Chip-Seq_ESCs_Mouse0.82118824
142TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.81648632
143SMAD_19615063_ChIP-ChIP_OVARY_Human0.81385490

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.56730019
2MP0003635_abnormal_synaptic_transmissio3.35911033
3MP0004270_analgesia3.23387218
4MP0003880_abnormal_central_pattern2.96071834
5MP0009780_abnormal_chondrocyte_physiolo2.80004935
6MP0008438_abnormal_cutaneous_collagen2.63736985
7MP0002909_abnormal_adrenal_gland2.59786832
8MP0009745_abnormal_behavioral_response2.55045044
9MP0009046_muscle_twitch2.52056379
10MP0002064_seizures2.51608224
11* MP0002063_abnormal_learning/memory/cond2.47714254
12MP0005409_darkened_coat_color2.42002722
13MP0002822_catalepsy2.23826208
14MP0002734_abnormal_mechanical_nocicepti2.18159795
15MP0001968_abnormal_touch/_nociception2.16071976
16MP0002272_abnormal_nervous_system2.11319064
17MP0003329_amyloid_beta_deposits2.08016835
18MP0004858_abnormal_nervous_system2.04304204
19MP0002837_dystrophic_cardiac_calcinosis2.00856585
20MP0002572_abnormal_emotion/affect_behav2.00639138
21MP0001486_abnormal_startle_reflex1.96781174
22MP0001501_abnormal_sleep_pattern1.88625530
23MP0005275_abnormal_skin_tensile1.88245269
24MP0003566_abnormal_cell_adhesion1.85841793
25MP0000751_myopathy1.83604672
26MP0000013_abnormal_adipose_tissue1.83531653
27MP0008569_lethality_at_weaning1.80118043
28MP0001958_emphysema1.76516256
29MP0003283_abnormal_digestive_organ1.74691015
30MP0001440_abnormal_grooming_behavior1.68349493
31MP0002733_abnormal_thermal_nociception1.66762248
32MP0005423_abnormal_somatic_nervous1.61479838
33MP0001970_abnormal_pain_threshold1.56902713
34MP0004043_abnormal_pH_regulation1.56126698
35MP0002735_abnormal_chemical_nociception1.53019944
36MP0004885_abnormal_endolymph1.51682081
37MP0005670_abnormal_white_adipose1.51534621
38MP0002067_abnormal_sensory_capabilities1.49481976
39MP0002736_abnormal_nociception_after1.49349019
40MP0004130_abnormal_muscle_cell1.49321978
41MP0004145_abnormal_muscle_electrophysio1.43183882
42MP0008961_abnormal_basal_metabolism1.41711253
43MP0003633_abnormal_nervous_system1.40233836
44MP0004811_abnormal_neuron_physiology1.39917022
45MP0010234_abnormal_vibrissa_follicle1.36592404
46MP0005058_abnormal_lysosome_morphology1.36547470
47MP0004272_abnormal_basement_membrane1.35743310
48MP0003279_aneurysm1.35653380
49MP0000579_abnormal_nail_morphology1.35369558
50MP0003123_paternal_imprinting1.33275911
51MP0003879_abnormal_hair_cell1.31485296
52MP0004924_abnormal_behavior1.31178323
53MP0005386_behavior/neurological_phenoty1.31178323
54MP0005503_abnormal_tendon_morphology1.30953739
55MP0005257_abnormal_intraocular_pressure1.29788457
56MP0000955_abnormal_spinal_cord1.27852696
57MP0002184_abnormal_innervation1.27170967
58MP0002089_abnormal_postnatal_growth/wei1.26544768
59MP0004036_abnormal_muscle_relaxation1.24963595
60MP0003690_abnormal_glial_cell1.23717662
61MP0005623_abnormal_meninges_morphology1.22857029
62MP0000747_muscle_weakness1.22830772
63MP0010386_abnormal_urinary_bladder1.22780010
64MP0005666_abnormal_adipose_tissue1.22175919
65MP0005167_abnormal_blood-brain_barrier1.21608008
66MP0002557_abnormal_social/conspecific_i1.17130260
67* MP0002066_abnormal_motor_capabilities/c1.15240344
68MP0003091_abnormal_cell_migration1.13048561
69MP0003075_altered_response_to1.11873308
70MP0005535_abnormal_body_temperature1.11757086
71MP0001348_abnormal_lacrimal_gland1.11634779
72MP0004215_abnormal_myocardial_fiber1.11632384
73* MP0002882_abnormal_neuron_morphology1.08590846
74MP0003631_nervous_system_phenotype1.08404738
75MP0000566_synostosis1.06462146
76MP0004085_abnormal_heartbeat1.06443128
77MP0002090_abnormal_vision1.06291451
78MP0003045_fibrosis1.05064921
79MP0000604_amyloidosis1.04555579
80MP0010368_abnormal_lymphatic_system1.04005263
81MP0003191_abnormal_cellular_cholesterol1.03963998
82MP0004084_abnormal_cardiac_muscle1.03394615
83MP0002896_abnormal_bone_mineralization1.02973556
84MP0000003_abnormal_adipose_tissue1.02962304
85MP0000920_abnormal_myelination1.02586586
86MP0004510_myositis1.01698282
87MP0002796_impaired_skin_barrier1.01490200
88MP0000778_abnormal_nervous_system1.00898154
89MP0002229_neurodegeneration1.00841014
90MP0003453_abnormal_keratinocyte_physiol0.99897779
91MP0005646_abnormal_pituitary_gland0.99108994
92MP0003634_abnormal_glial_cell0.97601194
93MP0002971_abnormal_brown_adipose0.96683141
94MP0001849_ear_inflammation0.93572797
95MP0002877_abnormal_melanocyte_morpholog0.92789055
96MP0004484_altered_response_of0.92781397
97MP0004233_abnormal_muscle_weight0.92618551
98MP0001984_abnormal_olfaction0.91114248
99MP0001299_abnormal_eye_distance/0.91014321
100MP0005023_abnormal_wound_healing0.90452306
101MP0001177_atelectasis0.90421238
102MP0005551_abnormal_eye_electrophysiolog0.90216898
103MP0002060_abnormal_skin_morphology0.89056674
104MP0008874_decreased_physiological_sensi0.88952797
105MP0000569_abnormal_digit_pigmentation0.88493940
106MP0001502_abnormal_circadian_rhythm0.88267869
107MP0005620_abnormal_muscle_contractility0.87942467
108MP0006276_abnormal_autonomic_nervous0.87738228
109MP0002295_abnormal_pulmonary_circulatio0.87243373
110MP0003122_maternal_imprinting0.85743928
111MP0001765_abnormal_ion_homeostasis0.83763983
112MP0002069_abnormal_eating/drinking_beha0.83570542
113MP0003705_abnormal_hypodermis_morpholog0.83017802
114MP0003137_abnormal_impulse_conducting0.80667576
115MP0004087_abnormal_muscle_fiber0.80010447
116MP0010329_abnormal_lipoprotein_level0.79894013
117MP0005165_increased_susceptibility_to0.79554788
118MP0005375_adipose_tissue_phenotype0.79416503
119MP0000678_abnormal_parathyroid_gland0.78903896
120MP0006138_congestive_heart_failure0.78889678
121MP0003172_abnormal_lysosome_physiology0.77248119
122MP0003632_abnormal_nervous_system0.76163418
123MP0002972_abnormal_cardiac_muscle0.76051417
124MP0000749_muscle_degeneration0.74543297
125MP0009840_abnormal_foam_cell0.74195872
126MP0005187_abnormal_penis_morphology0.74048955
127MP0002078_abnormal_glucose_homeostasis0.73508494
128MP0000230_abnormal_systemic_arterial0.72520596
129MP0003195_calcinosis0.71404949
130* MP0002152_abnormal_brain_morphology0.70796931
131MP0005076_abnormal_cell_differentiation0.70742220
132MP0001664_abnormal_digestion0.70252248
133MP0004185_abnormal_adipocyte_glucose0.70209959
134MP0002269_muscular_atrophy0.69685170
135MP0000762_abnormal_tongue_morphology0.68933340
136MP0005645_abnormal_hypothalamus_physiol0.68349627
137MP0005083_abnormal_biliary_tract0.67937171
138MP0008872_abnormal_physiological_respon0.65019822

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.13399535
2Focal motor seizures (HP:0011153)5.12410382
3Visual hallucinations (HP:0002367)4.38532914
4Focal seizures (HP:0007359)4.09608781
5Action tremor (HP:0002345)3.85091890
6Protrusio acetabuli (HP:0003179)3.80432929
7Obstructive sleep apnea (HP:0002870)3.76429709
8Supranuclear gaze palsy (HP:0000605)3.31122407
9Atonic seizures (HP:0010819)3.11381353
10Diplopia (HP:0000651)3.04123869
11Abnormality of binocular vision (HP:0011514)3.04123869
12Absence seizures (HP:0002121)2.99625873
13Bundle branch block (HP:0011710)2.99045997
14Generalized tonic-clonic seizures (HP:0002069)2.99040732
15Progressive cerebellar ataxia (HP:0002073)2.97406625
16Ventricular fibrillation (HP:0001663)2.91042089
17Ankle clonus (HP:0011448)2.85567306
18Papilledema (HP:0001085)2.83197331
19Epileptic encephalopathy (HP:0200134)2.76598396
20Depression (HP:0000716)2.75740135
21Dysdiadochokinesis (HP:0002075)2.72846062
22Cerebral aneurysm (HP:0004944)2.71764843
23Premature rupture of membranes (HP:0001788)2.71618008
24Postural instability (HP:0002172)2.64913923
25Vascular tortuosity (HP:0004948)2.64535511
26Dialeptic seizures (HP:0011146)2.64206594
27Arterial tortuosity (HP:0005116)2.60593166
28Intention tremor (HP:0002080)2.59807453
29Cerebral inclusion bodies (HP:0100314)2.58412868
30Pheochromocytoma (HP:0002666)2.57321274
31Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.57054203
32Abnormal social behavior (HP:0012433)2.55760910
33Impaired social interactions (HP:0000735)2.55760910
34Dysmetria (HP:0001310)2.55456289
35Dysmetric saccades (HP:0000641)2.55201548
36Febrile seizures (HP:0002373)2.52877050
37Neurofibrillary tangles (HP:0002185)2.51123133
38Insidious onset (HP:0003587)2.50196016
39Termporal pattern (HP:0011008)2.50196016
40Hemiplegia (HP:0002301)2.47811730
41Anxiety (HP:0000739)2.45355655
42Poor eye contact (HP:0000817)2.41822916
43Deep venous thrombosis (HP:0002625)2.39616635
44Impaired vibration sensation in the lower limbs (HP:0002166)2.38199927
45Truncal ataxia (HP:0002078)2.34677293
46Urinary bladder sphincter dysfunction (HP:0002839)2.34653506
47Aortic aneurysm (HP:0004942)2.33840016
48Gaze-evoked nystagmus (HP:0000640)2.31110813
49Shallow orbits (HP:0000586)2.29443122
50Rapidly progressive (HP:0003678)2.27580500
51Abnormality of the lower motor neuron (HP:0002366)2.27218818
52Torticollis (HP:0000473)2.26671847
53Resting tremor (HP:0002322)2.25098104
54Hyperacusis (HP:0010780)2.22658268
55Exercise-induced myalgia (HP:0003738)2.22458295
56Urinary urgency (HP:0000012)2.22182451
57Atrophic scars (HP:0001075)2.17588732
58Prolonged QT interval (HP:0001657)2.15298591
59Sudden death (HP:0001699)2.15188065
60Abnormal eating behavior (HP:0100738)2.14193770
61Scanning speech (HP:0002168)2.13627462
62Hyperparathyroidism (HP:0000843)2.10695946
63Lower limb amyotrophy (HP:0007210)2.10107256
64Hyporeflexia of lower limbs (HP:0002600)2.09788916
65Genetic anticipation (HP:0003743)2.08597536
66Megalencephaly (HP:0001355)2.07428038
67Syncope (HP:0001279)2.07228810
68Neuroendocrine neoplasm (HP:0100634)2.06551605
69Axonal loss (HP:0003447)2.01024904
70Difficulty running (HP:0009046)2.00855022
71Postural tremor (HP:0002174)2.00820280
72Status epilepticus (HP:0002133)1.99510907
73Focal dystonia (HP:0004373)1.98976534
74Broad-based gait (HP:0002136)1.97831721
75Aortic dissection (HP:0002647)1.97760957
76Bladder diverticulum (HP:0000015)1.97180079
77Vertebral compression fractures (HP:0002953)1.96581356
78Spastic gait (HP:0002064)1.96356205
79Myotonia (HP:0002486)1.95567427
80Fragile skin (HP:0001030)1.95303108
81Bradykinesia (HP:0002067)1.94954027
82Aplasia involving bones of the upper limbs (HP:0009823)1.94583910
83Increased variability in muscle fiber diameter (HP:0003557)1.94078665
84Macroorchidism (HP:0000053)1.93480878
85EEG with generalized epileptiform discharges (HP:0011198)1.93110811
86Agitation (HP:0000713)1.93081290
87Insomnia (HP:0100785)1.93021133
88Distal upper limb amyotrophy (HP:0007149)1.93019742
89Upper limb amyotrophy (HP:0009129)1.93019742
90Peripheral hypomyelination (HP:0007182)1.92993801
91Abnormal EKG (HP:0003115)1.92852224
92Akinesia (HP:0002304)1.91526857
93Hand muscle atrophy (HP:0009130)1.91075910
94Wormian bones (HP:0002645)1.90456381
95Foot dorsiflexor weakness (HP:0009027)1.90177414
96Epileptiform EEG discharges (HP:0011182)1.90076526
97Hypsarrhythmia (HP:0002521)1.88382764
98Lower limb muscle weakness (HP:0007340)1.88012682
99Abnormality of the Achilles tendon (HP:0005109)1.87644138
100Spinal cord compression (HP:0002176)1.87046542
101Hypercortisolism (HP:0001578)1.85445503
102Craniofacial dystonia (HP:0012179)1.84741481
103Mildly elevated creatine phosphokinase (HP:0008180)1.84495272
104Amblyopia (HP:0000646)1.84049501
105Ketoacidosis (HP:0001993)1.82663596
106Heart block (HP:0012722)1.81736966
107Increased circulating renin level (HP:0000848)1.81593052
108Apathy (HP:0000741)1.81379018
109Mitral stenosis (HP:0001718)1.80907184
110Hypoventilation (HP:0002791)1.80750465
111Distal lower limb amyotrophy (HP:0008944)1.79799042
112Aneurysm (HP:0002617)1.79796981
113Impaired smooth pursuit (HP:0007772)1.79718228
114Ankyloglossia (HP:0010296)1.79455951
115Buphthalmos (HP:0000557)1.78117553
116Spinal rigidity (HP:0003306)1.77141582
117Turricephaly (HP:0000262)1.76863944
118Central scotoma (HP:0000603)1.75889802
119Skin nodule (HP:0200036)1.75614662
120Neuronal loss in central nervous system (HP:0002529)1.75390338
121Hammertoe (HP:0001765)1.75279345
122Tetraplegia (HP:0002445)1.74839442
123Bronchomalacia (HP:0002780)1.73618630
124Atrioventricular block (HP:0001678)1.73067271
125Hyperventilation (HP:0002883)1.72792210
126Neoplasm of the heart (HP:0100544)1.72533122
127Achilles tendon contracture (HP:0001771)1.72383921
128Hemiparesis (HP:0001269)1.71653366
129Annular pancreas (HP:0001734)1.71516763
130Broad metatarsal (HP:0001783)1.70743849
131Nuclear cataract (HP:0100018)1.70631082
132Ulnar bowing (HP:0003031)1.70508042
133Distal lower limb muscle weakness (HP:0009053)1.70082555
134Right ventricular cardiomyopathy (HP:0011663)1.70077998
135Onion bulb formation (HP:0003383)1.69956705
136Ventricular arrhythmia (HP:0004308)1.69239786
137Neonatal short-limb short stature (HP:0008921)1.69120815
138Lower limb asymmetry (HP:0100559)1.68930032
139Abnormality of the corticospinal tract (HP:0002492)1.68728366
140Rigidity (HP:0002063)1.68654139
141Abnormal atrioventricular conduction (HP:0005150)1.68282644
142Mitral regurgitation (HP:0001653)1.67984464
143Hyperextensible skin (HP:0000974)1.67569587
144Aplasia of the phalanges of the hand (HP:0009802)1.67354121
145Aplasia involving bones of the extremities (HP:0009825)1.67354121
146Complement deficiency (HP:0004431)1.66362778
147Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.66073401
148Abnormality of the foot musculature (HP:0001436)1.65767129
149Distal sensory impairment (HP:0002936)1.61535367
150Diminished motivation (HP:0000745)1.61460851
151Growth hormone excess (HP:0000845)1.58855532

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.36386216
2MAP3K93.22260617
3EPHA42.92257824
4PRKD32.82744997
5KSR22.38339973
6DAPK22.35757796
7PRPF4B2.29425783
8NTRK12.27700418
9MAP3K42.25483618
10PAK62.19967829
11MINK11.96428768
12MAP3K21.95798992
13CAMKK11.91559706
14TRIB31.88818930
15LMTK21.79777358
16RIPK11.71390055
17MAP2K41.70772689
18EEF2K1.62840561
19STK381.62083845
20MARK11.49544328
21PHKG11.40110870
22PHKG21.40110870
23FGFR41.33494799
24PRKCH1.33227695
25WNK11.31202968
26RET1.31083372
27CDK51.28648857
28TESK11.27549015
29MAP2K71.26584953
30WNK41.25963763
31PINK11.23028327
32TYRO31.22605917
33CAMK1G1.21478585
34RIPK41.19965250
35NTRK21.18994477
36PDGFRA1.17909458
37GRK51.13944503
38STK391.09077718
39CAMKK21.07550377
40PAK31.06128015
41LATS11.06108707
42MAP3K11.02942556
43LATS21.02842495
44FER1.01936552
45MYLK1.01555937
46OXSR10.98432082
47FRK0.95804995
48DMPK0.95475082
49DDR20.93692249
50SGK2230.93675944
51SGK4940.93675944
52UHMK10.92404374
53SIK20.91802134
54SGK30.91592706
55PDPK10.90798285
56MAPK120.90257754
57TAOK10.89457406
58KSR10.88207382
59EPHA20.84948634
60STK110.84694069
61CDC42BPA0.84231971
62PKN20.82977399
63IRAK30.82620878
64CAMK10.82258025
65MST1R0.81733799
66PTK2B0.81583283
67MAP3K70.81298061
68PDK10.80383282
69ALK0.78972729
70SCYL20.78939580
71PNCK0.78814777
72PRKCG0.77450551
73FGFR30.77243534
74INSRR0.76806755
75PAK20.76369613
76DAPK10.76353954
77NEK60.75499744
78CDK120.75275541
79FGFR20.74058590
80MET0.73869296
81MAP3K130.73737834
82MARK20.72746480
83AKT30.71992130
84CAMK2A0.71962070
85PDK40.70685342
86PDK30.70685342
87CDK11A0.70161813
88MOS0.69477420
89PTK20.69416213
90FES0.68977740
91CDK190.67612873
92SIK10.67423227
93TTN0.67082574
94RPS6KA20.66282335
95CAMK2D0.66116141
96MAP3K120.64943365
97CAMK2B0.64647552
98MAP2K10.64450973
99ARAF0.63699658
100PRKG20.63650944
101SGK20.63433967
102PLK20.63146389
103MAPKAPK30.63083277
104SGK10.62954707
105CAMK1D0.62040314
106PRKD10.61750017
107LIMK10.61158848
108DAPK30.60548983
109PTK60.59955882
110ROCK20.59049569
111NEK10.58945740
112MAPK100.58498886
113CAMK2G0.56705544
114MAP3K60.55997190
115PRKD20.54392328
116MTOR0.53716320
117ICK0.51905228
118CDK150.51835346
119CDK140.51563484
120PDGFRB0.51077329
121BMX0.51037538
122ERN10.50985193
123PRKCE0.50790668
124RPS6KA30.49470016
125BRAF0.49248346
126HIPK20.48976618
127TNK20.48263027
128CDK180.47692023
129ROCK10.47244180
130TAOK20.43040882
131JAK10.39040777

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.48739747
2Nitrogen metabolism_Homo sapiens_hsa009102.37032746
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.20793045
4GABAergic synapse_Homo sapiens_hsa047272.06833931
5Nicotine addiction_Homo sapiens_hsa050332.03674973
6Olfactory transduction_Homo sapiens_hsa047402.00067368
7Circadian entrainment_Homo sapiens_hsa047131.98286198
8Insulin secretion_Homo sapiens_hsa049111.95842625
9Long-term potentiation_Homo sapiens_hsa047201.92750432
10Glutamatergic synapse_Homo sapiens_hsa047241.86404999
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.82737713
12Salivary secretion_Homo sapiens_hsa049701.82718002
13Gastric acid secretion_Homo sapiens_hsa049711.77734519
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.76332387
15Morphine addiction_Homo sapiens_hsa050321.70673891
16Amphetamine addiction_Homo sapiens_hsa050311.69876723
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.62229479
18Dopaminergic synapse_Homo sapiens_hsa047281.59563727
19Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.56529921
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56212476
21Cholinergic synapse_Homo sapiens_hsa047251.52699522
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.52574496
23Renin secretion_Homo sapiens_hsa049241.46698999
24Type II diabetes mellitus_Homo sapiens_hsa049301.43539900
25Taste transduction_Homo sapiens_hsa047421.31916356
26Oxytocin signaling pathway_Homo sapiens_hsa049211.31313836
27Cocaine addiction_Homo sapiens_hsa050301.28753714
28ECM-receptor interaction_Homo sapiens_hsa045121.22999955
29Long-term depression_Homo sapiens_hsa047301.21238867
30Pancreatic secretion_Homo sapiens_hsa049721.21222126
31GnRH signaling pathway_Homo sapiens_hsa049121.20175401
32Calcium signaling pathway_Homo sapiens_hsa040201.15981834
33Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.12794122
34Vitamin B6 metabolism_Homo sapiens_hsa007501.12237081
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.11743443
36cAMP signaling pathway_Homo sapiens_hsa040241.09127274
37Estrogen signaling pathway_Homo sapiens_hsa049151.08727163
38Histidine metabolism_Homo sapiens_hsa003401.08371189
39Gap junction_Homo sapiens_hsa045401.06235589
40Bile secretion_Homo sapiens_hsa049761.06166180
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05473237
42Dorso-ventral axis formation_Homo sapiens_hsa043201.05181016
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03696338
44Dilated cardiomyopathy_Homo sapiens_hsa054141.03429180
45Serotonergic synapse_Homo sapiens_hsa047261.02422990
46Thyroid hormone synthesis_Homo sapiens_hsa049181.00688231
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.98996578
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98911239
49Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97994481
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95633296
51Glioma_Homo sapiens_hsa052140.95528319
52Phenylalanine metabolism_Homo sapiens_hsa003600.95082234
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.94584744
54Collecting duct acid secretion_Homo sapiens_hsa049660.90079135
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.87808889
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83083609
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82155939
58Melanogenesis_Homo sapiens_hsa049160.81466218
59Other glycan degradation_Homo sapiens_hsa005110.81413511
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80048375
61Cardiac muscle contraction_Homo sapiens_hsa042600.79704595
62Arginine biosynthesis_Homo sapiens_hsa002200.79285633
63Glucagon signaling pathway_Homo sapiens_hsa049220.78001923
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.76767821
65Butanoate metabolism_Homo sapiens_hsa006500.76031437
66ErbB signaling pathway_Homo sapiens_hsa040120.75452538
67Vibrio cholerae infection_Homo sapiens_hsa051100.75099793
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74763207
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.74664326
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72757556
71Proteoglycans in cancer_Homo sapiens_hsa052050.71943394
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70086999
73Axon guidance_Homo sapiens_hsa043600.70084410
74mTOR signaling pathway_Homo sapiens_hsa041500.69128054
75Arginine and proline metabolism_Homo sapiens_hsa003300.67789897
76Fatty acid biosynthesis_Homo sapiens_hsa000610.64999678
77Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64978279
78Insulin signaling pathway_Homo sapiens_hsa049100.62865293
79Adherens junction_Homo sapiens_hsa045200.61748296
80Mineral absorption_Homo sapiens_hsa049780.60784735
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60778620
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60644219
83VEGF signaling pathway_Homo sapiens_hsa043700.60376961
84Complement and coagulation cascades_Homo sapiens_hsa046100.59934706
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59293282
86Chronic myeloid leukemia_Homo sapiens_hsa052200.58453772
87Circadian rhythm_Homo sapiens_hsa047100.57508181
88Phototransduction_Homo sapiens_hsa047440.56957568
89Choline metabolism in cancer_Homo sapiens_hsa052310.55810934
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55625061
91Inositol phosphate metabolism_Homo sapiens_hsa005620.55507936
92Insulin resistance_Homo sapiens_hsa049310.55241672
93Protein digestion and absorption_Homo sapiens_hsa049740.55062203
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.54753411
95Non-small cell lung cancer_Homo sapiens_hsa052230.53929478
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.53078975
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51319523
98Glycerolipid metabolism_Homo sapiens_hsa005610.50707430
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49965824
100Endocytosis_Homo sapiens_hsa041440.49702310
101Rap1 signaling pathway_Homo sapiens_hsa040150.48013988
102Renal cell carcinoma_Homo sapiens_hsa052110.46415914
103Propanoate metabolism_Homo sapiens_hsa006400.46189912
104Ovarian steroidogenesis_Homo sapiens_hsa049130.46157031
105AMPK signaling pathway_Homo sapiens_hsa041520.45785947
106MAPK signaling pathway_Homo sapiens_hsa040100.45721877
107PPAR signaling pathway_Homo sapiens_hsa033200.43625326
108Focal adhesion_Homo sapiens_hsa045100.43596098
109Endometrial cancer_Homo sapiens_hsa052130.43188628
110Amoebiasis_Homo sapiens_hsa051460.43110477
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43097397
112Fatty acid metabolism_Homo sapiens_hsa012120.42533809
113Prion diseases_Homo sapiens_hsa050200.41246463
114Ras signaling pathway_Homo sapiens_hsa040140.40510298
115Tight junction_Homo sapiens_hsa045300.40503774
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.40489865
117Maturity onset diabetes of the young_Homo sapiens_hsa049500.40333309
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.38307838

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