BCL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.61934743
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.61934743
3antigen processing and presentation of endogenous antigen (GO:0019883)4.50737320
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.15761873
5negative regulation of cell killing (GO:0031342)4.15761873
6positive regulation of gamma-delta T cell activation (GO:0046645)4.06060127
7detection of other organism (GO:0098543)3.81270924
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.78922408
9positive regulation by organism of defense response of other organism involved in symbiotic interact3.78922408
10modulation by symbiont of host immune response (GO:0052553)3.78922408
11positive regulation by symbiont of host defense response (GO:0052509)3.78922408
12modulation by symbiont of host defense response (GO:0052031)3.78922408
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.78922408
14detection of bacterium (GO:0016045)3.68143372
15positive regulation of interferon-alpha production (GO:0032727)3.67573362
16regulation of vitamin D biosynthetic process (GO:0060556)3.65745183
17response to peptidoglycan (GO:0032494)3.63912341
18regulation of interferon-alpha production (GO:0032647)3.61229966
19NIK/NF-kappaB signaling (GO:0038061)3.60271217
20regulation of interleukin-12 biosynthetic process (GO:0045075)3.60101073
21* immunoglobulin mediated immune response (GO:0016064)3.54799519
22positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.51737131
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.50513302
24response to type I interferon (GO:0034340)3.44355400
25cellular response to type I interferon (GO:0071357)3.43410615
26type I interferon signaling pathway (GO:0060337)3.43410615
27regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.43303178
28regulation of T-helper 2 cell differentiation (GO:0045628)3.41845148
29JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.40187450
30detection of molecule of bacterial origin (GO:0032490)3.32556676
31detection of external biotic stimulus (GO:0098581)3.32245051
32negative regulation of interleukin-12 production (GO:0032695)3.30361859
33positive regulation of humoral immune response (GO:0002922)3.24983820
34negative regulation of erythrocyte differentiation (GO:0045647)3.24000306
35regulation of gamma-delta T cell activation (GO:0046643)3.20551537
36regulation of vitamin metabolic process (GO:0030656)3.20016500
37regulation of gamma-delta T cell differentiation (GO:0045586)3.16982367
38positive regulation of type 2 immune response (GO:0002830)3.14643282
39response to muramyl dipeptide (GO:0032495)3.13193115
40regulation of antigen processing and presentation (GO:0002577)3.09478734
41positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.09273081
42* B cell mediated immunity (GO:0019724)3.08097862
43regulation of interferon-beta biosynthetic process (GO:0045357)3.07212096
44tolerance induction (GO:0002507)3.06258538
45interferon-gamma-mediated signaling pathway (GO:0060333)3.05100160
46neutrophil activation involved in immune response (GO:0002283)3.04476845
47regulation of cytokine secretion involved in immune response (GO:0002739)3.00056537
48myeloid dendritic cell differentiation (GO:0043011)2.97479287
49regulation of type I interferon-mediated signaling pathway (GO:0060338)2.96489503
50positive regulation of Cdc42 GTPase activity (GO:0043089)2.95764523
51detection of biotic stimulus (GO:0009595)2.95072220
52regulation of T cell tolerance induction (GO:0002664)2.95065708
53positive regulation of chemokine biosynthetic process (GO:0045080)2.94901966
54lipopolysaccharide-mediated signaling pathway (GO:0031663)2.94829199
55neutrophil activation (GO:0042119)2.94269791
56positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.93448764
57macrophage activation (GO:0042116)2.92106709
58myeloid cell activation involved in immune response (GO:0002275)2.84243226
59regulation of type 2 immune response (GO:0002828)2.83180068
60negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.82870134
61* germinal center formation (GO:0002467)2.82829822
62macrophage activation involved in immune response (GO:0002281)2.81364738
63T cell migration (GO:0072678)2.80923724
64positive regulation of interferon-beta production (GO:0032728)2.80456592
65regulation of response to interferon-gamma (GO:0060330)2.78184225
66negative regulation of cytokine production involved in immune response (GO:0002719)2.77645592
67leukocyte aggregation (GO:0070486)2.76785814
68regulation of podosome assembly (GO:0071801)2.76388558
69regulation of T-helper 1 cell differentiation (GO:0045625)2.76194129
70negative regulation of interleukin-6 production (GO:0032715)2.75995166
71regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.75665270
72branching involved in labyrinthine layer morphogenesis (GO:0060670)2.74068170
73cellular extravasation (GO:0045123)2.73907282
74response to interferon-beta (GO:0035456)2.73510807
75negative regulation of production of molecular mediator of immune response (GO:0002701)2.73029960
76regulation of B cell receptor signaling pathway (GO:0050855)2.71579445
77myeloid dendritic cell activation (GO:0001773)2.70088677
78positive regulation of B cell differentiation (GO:0045579)2.70042488
79positive regulation of NF-kappaB import into nucleus (GO:0042346)2.69504370
80regulation of tolerance induction (GO:0002643)2.69258931
81regulation of mast cell degranulation (GO:0043304)2.68494727
82cellular response to virus (GO:0098586)2.65468080
83regulation of membrane protein ectodomain proteolysis (GO:0051043)2.64528729
84regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.63895807
85respiratory burst (GO:0045730)2.63115884
86regulation of heterotypic cell-cell adhesion (GO:0034114)2.62928952
87interferon-gamma secretion (GO:0072643)2.62639139
88positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.61322892
89negative regulation of innate immune response (GO:0045824)2.60509683
90positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.60225843
91dendritic cell differentiation (GO:0097028)2.59170943
92response to host immune response (GO:0052572)2.58813473
93response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.58813473
94negative regulation of lymphocyte mediated immunity (GO:0002707)2.58580317
95negative regulation of T cell mediated immunity (GO:0002710)2.56827474
96regulation of interleukin-12 production (GO:0032655)2.56616622
97production of molecular mediator involved in inflammatory response (GO:0002532)2.56006101
98regulation of chronic inflammatory response (GO:0002676)2.55462405
99response to interferon-gamma (GO:0034341)2.54980796
100low-density lipoprotein particle clearance (GO:0034383)2.54845000
101regulation of superoxide anion generation (GO:0032928)2.54679791
102positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.53429463
103negative regulation of myeloid cell apoptotic process (GO:0033033)2.53035454
104cellular response to lipopolysaccharide (GO:0071222)2.52914860
105positive regulation of immunoglobulin mediated immune response (GO:0002891)2.52802460
106positive regulation of B cell mediated immunity (GO:0002714)2.52802460
107positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.52638206
108regulation of interleukin-6 production (GO:0032675)2.52222011
109regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.51580910
110positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.51393741
111negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.51207113
112cellular response to molecule of bacterial origin (GO:0071219)2.50791694
113positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.50191822
114positive regulation of cellular amide metabolic process (GO:0034250)2.50152521
115negative regulation of leukocyte mediated immunity (GO:0002704)2.49904881
116acute-phase response (GO:0006953)2.48533243
117protein carboxylation (GO:0018214)2.48236456
118peptidyl-glutamic acid carboxylation (GO:0017187)2.48236456
119cellular response to interferon-gamma (GO:0071346)2.47395548
120regulation of cholesterol homeostasis (GO:2000188)2.47231761
121* positive regulation of cytokine biosynthetic process (GO:0042108)2.46636540
122regulation of B cell differentiation (GO:0045577)2.46343185
123positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.46334698
124positive regulation of natural killer cell differentiation (GO:0032825)2.46305669
125positive regulation of antigen processing and presentation (GO:0002579)2.45938445
126granulocyte activation (GO:0036230)2.45308694
127Arp2/3 complex-mediated actin nucleation (GO:0034314)2.44058927
128positive regulation of interleukin-12 production (GO:0032735)2.43893326
129regulation of cholesterol storage (GO:0010885)2.43529980
130regulation of chemokine biosynthetic process (GO:0045073)2.42653059
131positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.42551437
132negative regulation of growth of symbiont in host (GO:0044130)2.42486911
133negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.42486911
134modulation of growth of symbiont involved in interaction with host (GO:0044144)2.42486911
135regulation of growth of symbiont in host (GO:0044126)2.42486911
136* defense response to protozoan (GO:0042832)2.42378997
137regulation of dendritic cell antigen processing and presentation (GO:0002604)2.41588470
138response to interferon-alpha (GO:0035455)2.41023904
139response to host (GO:0075136)2.40470707
140response to host defenses (GO:0052200)2.40470707
141response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.40470707
142antigen processing and presentation via MHC class Ib (GO:0002475)2.39362565
143complement activation, alternative pathway (GO:0006957)2.38730430
144negative regulation of viral genome replication (GO:0045071)2.38367833
145* response to protozoan (GO:0001562)2.38180086
146hydrogen peroxide biosynthetic process (GO:0050665)2.38167351
147triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.37879016

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.50258928
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.50257274
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.50107968
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.44472186
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.92688353
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.88708740
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.75908046
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.71855384
9* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.70991950
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.68777354
11* RXR_22158963_ChIP-Seq_LIVER_Mouse2.59265903
12* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.54029816
13* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.49104927
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.42426072
15* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.39783344
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.35809799
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.33503157
18TP63_17297297_ChIP-ChIP_HaCaT_Human2.30830860
19E2F7_22180533_ChIP-Seq_HELA_Human2.28675976
20MYC_22102868_ChIP-Seq_BL_Human2.28230077
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.22996943
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.16081365
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.13482269
24* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.05205704
25* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.03917193
26* STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.03612762
27VDR_21846776_ChIP-Seq_THP-1_Human1.99882442
28MAF_26560356_Chip-Seq_TH1_Human1.96950412
29* LXR_22158963_ChIP-Seq_LIVER_Mouse1.90588029
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.84279573
31EGR1_23403033_ChIP-Seq_LIVER_Mouse1.79818496
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.72370028
33CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.71278991
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.69740785
35* MYB_26560356_Chip-Seq_TH2_Human1.68775075
36* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.68086424
37FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.64327623
38* MYB_26560356_Chip-Seq_TH1_Human1.64285717
39PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.64046571
40SCL_19346495_ChIP-Seq_HPC-7_Human1.62107085
41SPI1_23547873_ChIP-Seq_NB4_Human1.61318161
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.60732812
43* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.59452762
44* ELK3_25401928_ChIP-Seq_HUVEC_Human1.57136225
45VDR_24763502_ChIP-Seq_THP-1_Human1.56689783
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.56518631
47* ESR2_21235772_ChIP-Seq_MCF-7_Human1.55580716
48* TCF7_22412390_ChIP-Seq_EML_Mouse1.54989346
49* UTX_26944678_Chip-Seq_JUKART_Human1.52321178
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.51624414
51FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.51124535
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50704094
53* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.49920464
54* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.49423155
55VDR_24787735_ChIP-Seq_THP-1_Human1.44441694
56* RUNX_20019798_ChIP-Seq_JUKART_Human1.34800106
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31816329
58* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31450407
59EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.30224229
60KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.29226641
61KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.29226641
62KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.29226641
63KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.28265755
64GATA1_19941827_ChIP-Seq_MEL_Mouse1.27732993
65MAF_26560356_Chip-Seq_TH2_Human1.26386837
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.23823440
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22770966
68CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21118309
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18742690
70PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18324232
71* KDM2B_26808549_Chip-Seq_DND41_Human1.17643986
72CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16970599
73PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16788150
74* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15810365
75GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15180438
76GATA2_21666600_ChIP-Seq_HMVEC_Human1.14745634
77* BCOR_27268052_Chip-Seq_Bcells_Human1.13148956
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.12599156
79GATA1_19941826_ChIP-Seq_K562_Human1.12533447
80* BCL6_27268052_Chip-Seq_Bcells_Human1.12475244
81KDM2B_26808549_Chip-Seq_K562_Human1.12295833
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10839396
83* LXR_22292898_ChIP-Seq_THP-1_Human1.10832053
84KDM2B_26808549_Chip-Seq_JURKAT_Human1.10523272
85FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10234196
86* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09647170
87PU_27001747_Chip-Seq_BMDM_Mouse1.08886951
88KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08451136
89NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.06385249
90SA1_27219007_Chip-Seq_ERYTHROID_Human1.05557403
91SPI1_23127762_ChIP-Seq_K562_Human1.04151399
92TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03896653
93RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03088757
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02029257
95PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01949672
96* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01138976
97NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99449289
98RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98737714
99* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98188184
100* NCOR1_26117541_ChIP-Seq_K562_Human0.98041157
101ELF1_20517297_ChIP-Seq_JURKAT_Human0.96472687
102* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96317680
103MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95924357
104TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95602792
105HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95425116
106TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95307007
107CLOCK_20551151_ChIP-Seq_293T_Human0.94353572
108POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93969456
109* RACK7_27058665_Chip-Seq_MCF-7_Human0.93878421
110SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93823702
111* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93733828
112* ESR1_21235772_ChIP-Seq_MCF-7_Human0.93646964
113SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93384827
114GATA3_27048872_Chip-Seq_THYMUS_Human0.92973489
115TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91979061
116CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89491469
117ATF3_27146783_Chip-Seq_COLON_Human0.88286711
118SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.86897162
119LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.86607862
120TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86502811
121CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85994005
122PU.1_20513432_ChIP-Seq_Bcells_Mouse0.83377465
123* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83277073
124* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.81940588

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.35578027
2MP0003436_decreased_susceptibility_to3.24464395
3MP0003303_peritoneal_inflammation3.15217410
4MP0009785_altered_susceptibility_to2.96653043
5MP0000685_abnormal_immune_system2.87044794
6MP0001790_abnormal_immune_system2.64893713
7MP0005387_immune_system_phenotype2.64893713
8* MP0001800_abnormal_humoral_immune2.45282804
9MP0003724_increased_susceptibility_to2.43382818
10MP0005000_abnormal_immune_tolerance2.42546840
11* MP0005025_abnormal_response_to2.39739043
12MP0009840_abnormal_foam_cell2.28533597
13MP0005360_urolithiasis2.25000559
14MP0005671_abnormal_response_to2.24283431
15MP0003300_gastrointestinal_ulcer2.22815995
16MP0006082_CNS_inflammation2.22376645
17MP0002148_abnormal_hypersensitivity_rea2.17302295
18* MP0002452_abnormal_antigen_presenting2.14679812
19MP0005451_abnormal_body_composition2.14059404
20MP0004510_myositis2.13988776
21* MP0002419_abnormal_innate_immunity2.12292398
22MP0001853_heart_inflammation2.12061453
23* MP0002723_abnormal_immune_serum2.09847426
24MP0002139_abnormal_hepatobiliary_system2.01938703
25MP0010155_abnormal_intestine_physiology2.01794719
26MP0010352_gastrointestinal_tract_polyps1.97744087
27MP0004947_skin_inflammation1.93673320
28* MP0001819_abnormal_immune_cell1.83505922
29* MP0002420_abnormal_adaptive_immunity1.82776111
30MP0002405_respiratory_system_inflammati1.80542795
31MP0009278_abnormal_bone_marrow1.75978767
32MP0001845_abnormal_inflammatory_respons1.72984696
33MP0002138_abnormal_hepatobiliary_system1.70844295
34MP0003191_abnormal_cellular_cholesterol1.69376395
35MP0009333_abnormal_splenocyte_physiolog1.65086989
36MP0005464_abnormal_platelet_physiology1.64606732
37MP0008004_abnormal_stomach_pH1.64404755
38MP0003763_abnormal_thymus_physiology1.63800487
39MP0002166_altered_tumor_susceptibility1.63510349
40MP0005397_hematopoietic_system_phenotyp1.59180236
41MP0001545_abnormal_hematopoietic_system1.59180236
42MP0005085_abnormal_gallbladder_physiolo1.58256477
43MP0008469_abnormal_protein_level1.56726769
44MP0001533_abnormal_skeleton_physiology1.54183206
45* MP0002398_abnormal_bone_marrow1.53101673
46MP0003705_abnormal_hypodermis_morpholog1.51219832
47* MP0000716_abnormal_immune_system1.49789321
48MP0009764_decreased_sensitivity_to1.46370076
49MP0005365_abnormal_bile_salt1.45959247
50MP0003806_abnormal_nucleotide_metabolis1.45315791
51MP0002006_tumorigenesis1.44041250
52MP0002254_reproductive_system_inflammat1.43370276
53MP0003448_altered_tumor_morphology1.42679226
54MP0001873_stomach_inflammation1.42672666
55MP0005076_abnormal_cell_differentiation1.38411956
56* MP0000689_abnormal_spleen_morphology1.37863156
57MP0003453_abnormal_keratinocyte_physiol1.34683239
58MP0008875_abnormal_xenobiotic_pharmacok1.34378116
59MP0002396_abnormal_hematopoietic_system1.32966299
60MP0000609_abnormal_liver_physiology1.32620460
61MP0008260_abnormal_autophagy1.29997270
62* MP0002722_abnormal_immune_system1.29563109
63MP0003866_abnormal_defecation1.28357602
64* MP0002429_abnormal_blood_cell1.26941169
65MP0005023_abnormal_wound_healing1.24283481
66MP0003183_abnormal_peptide_metabolism1.19569037
67MP0000490_abnormal_crypts_of1.16519320
68MP0000343_altered_response_to1.15368896
69MP0003566_abnormal_cell_adhesion1.12461502
70MP0005164_abnormal_response_to1.10451614
71MP0002332_abnormal_exercise_endurance1.09377801
72MP0003252_abnormal_bile_duct1.09189041
73MP0000858_altered_metastatic_potential1.08445600
74MP0005058_abnormal_lysosome_morphology1.07909182
75* MP0009763_increased_sensitivity_to1.06390560
76MP0001663_abnormal_digestive_system1.04139889
77MP0002933_joint_inflammation1.03458799
78MP0005310_abnormal_salivary_gland1.02545821
79MP0010307_abnormal_tumor_latency1.02301452
80MP0003091_abnormal_cell_migration1.01957376
81MP0005319_abnormal_enzyme/_coenzyme1.01932800
82MP0003075_altered_response_to1.00830017
83MP0010329_abnormal_lipoprotein_level1.00558710
84MP0005083_abnormal_biliary_tract0.99521333
85MP0005167_abnormal_blood-brain_barrier0.97652516
86MP0004858_abnormal_nervous_system0.96832781
87MP0005166_decreased_susceptibility_to0.96324467
88MP0000598_abnormal_liver_morphology0.93289399
89MP0004808_abnormal_hematopoietic_stem0.91340535
90MP0003690_abnormal_glial_cell0.91231746
91MP0003186_abnormal_redox_activity0.91185902
92MP0002277_abnormal_respiratory_mucosa0.89463956
93MP0006054_spinal_hemorrhage0.89318459
94MP0004883_abnormal_blood_vessel0.88954540
95MP0000249_abnormal_blood_vessel0.85667911
96MP0001851_eye_inflammation0.85394231
97MP0000703_abnormal_thymus_morphology0.84961385
98MP0003828_pulmonary_edema0.83853149
99MP0001666_abnormal_nutrient_absorption0.83413324
100MP0001542_abnormal_bone_strength0.81891235
101MP0000465_gastrointestinal_hemorrhage0.81290430
102MP0002998_abnormal_bone_remodeling0.78688083
103MP0002019_abnormal_tumor_incidence0.78401648
104MP0003656_abnormal_erythrocyte_physiolo0.76052272
105MP0002132_abnormal_respiratory_system0.74837854
106MP0003795_abnormal_bone_structure0.72273182
107MP0003045_fibrosis0.71891785
108MP0000604_amyloidosis0.71743395
109MP0005390_skeleton_phenotype0.71046335
110MP0008874_decreased_physiological_sensi0.70844907
111MP0003172_abnormal_lysosome_physiology0.70569398
112MP0002136_abnormal_kidney_physiology0.70364011
113MP0009765_abnormal_xenobiotic_induced0.70326773
114MP0009643_abnormal_urine_homeostasis0.69042168
115MP0008873_increased_physiological_sensi0.69030625
116MP0005381_digestive/alimentary_phenotyp0.68997460
117MP0000477_abnormal_intestine_morphology0.68416758
118MP0005165_increased_susceptibility_to0.68166260
119MP0003279_aneurysm0.67484830
120MP0005666_abnormal_adipose_tissue0.67338131
121MP0005332_abnormal_amino_acid0.65939027
122MP0004019_abnormal_vitamin_homeostasis0.65914414
123MP0001849_ear_inflammation0.65871849

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.04043210
2Elevated erythrocyte sedimentation rate (HP:0003565)4.58257673
3Abnormality of glycolipid metabolism (HP:0010969)4.44067311
4Abnormality of liposaccharide metabolism (HP:0010968)4.44067311
5Abnormality of glycosphingolipid metabolism (HP:0004343)4.44067311
6Recurrent gram-negative bacterial infections (HP:0005420)4.28752623
7Recurrent abscess formation (HP:0002722)4.16924498
8Myositis (HP:0100614)4.11899460
9Recurrent bacterial skin infections (HP:0005406)4.05092767
10Orchitis (HP:0100796)3.67655722
11Pustule (HP:0200039)3.47443400
12Autoimmune thrombocytopenia (HP:0001973)3.45365713
13Systemic lupus erythematosus (HP:0002725)3.44332530
14Abnormality of macrophages (HP:0004311)3.39517337
15Dysostosis multiplex (HP:0000943)3.38492407
16Recurrent fungal infections (HP:0002841)3.35527684
17Loss of speech (HP:0002371)3.34365272
18Interstitial pulmonary disease (HP:0006530)3.22010898
19Vasculitis (HP:0002633)3.21211859
20Mediastinal lymphadenopathy (HP:0100721)3.19493663
21Increased cerebral lipofuscin (HP:0011813)3.18853879
22Gingival bleeding (HP:0000225)3.17372318
23Retrobulbar optic neuritis (HP:0100654)3.02198339
24Optic neuritis (HP:0100653)3.02198339
25Myocardial infarction (HP:0001658)3.01149901
26Abnormality of monocarboxylic acid metabolism (HP:0010996)2.99178002
27Stomatitis (HP:0010280)2.99057402
28IgM deficiency (HP:0002850)2.93474813
29Recurrent skin infections (HP:0001581)2.93071056
30Deep venous thrombosis (HP:0002625)2.88215499
31Recurrent viral infections (HP:0004429)2.86006769
32Malnutrition (HP:0004395)2.85226761
33Nasal polyposis (HP:0100582)2.84561826
34Spontaneous hematomas (HP:0007420)2.81242470
35Recurrent bronchitis (HP:0002837)2.79726335
36Complement deficiency (HP:0004431)2.77343185
37Abnormality of glycosaminoglycan metabolism (HP:0004371)2.75279876
38Abnormality of mucopolysaccharide metabolism (HP:0011020)2.75279876
39Abnormality of polysaccharide metabolism (HP:0011012)2.75279876
40Increased IgE level (HP:0003212)2.75130183
41Joint hemorrhage (HP:0005261)2.74954395
42Chronic otitis media (HP:0000389)2.72178963
43Abnormality of the nasal mucosa (HP:0000433)2.71883511
44Abnormal delayed hypersensitivity skin test (HP:0002963)2.70250423
45Cellulitis (HP:0100658)2.69631788
46Abnormality of the common coagulation pathway (HP:0010990)2.65913813
47Inflammation of the large intestine (HP:0002037)2.64629811
48Abnormality of T cell physiology (HP:0011840)2.64087946
49Xanthomatosis (HP:0000991)2.62306019
50Mucopolysacchariduria (HP:0008155)2.61263989
51Urinary glycosaminoglycan excretion (HP:0003541)2.61263989
52Abnormality of complement system (HP:0005339)2.60608182
53Urticaria (HP:0001025)2.59580163
54Increased neuronal autofluorescent lipopigment (HP:0002074)2.59105938
55Gastrointestinal inflammation (HP:0004386)2.54841620
56Gingivitis (HP:0000230)2.54016426
57Colitis (HP:0002583)2.52822234
58Disinhibition (HP:0000734)2.51827236
59Anorexia (HP:0002039)2.51642214
60Gastrointestinal infarctions (HP:0005244)2.51269102
61Abnormality of aromatic amino acid family metabolism (HP:0004338)2.49902587
62Intrahepatic cholestasis (HP:0001406)2.48188635
63Increased serum ferritin (HP:0003281)2.47841872
64Meningitis (HP:0001287)2.47761768
65Increased IgM level (HP:0003496)2.46329513
66Gangrene (HP:0100758)2.45218614
67Arterial thrombosis (HP:0004420)2.44588461
68Esophageal varix (HP:0002040)2.43065712
69Vacuolated lymphocytes (HP:0001922)2.38309832
70Axonal loss (HP:0003447)2.38221365
71Abnormality of T cells (HP:0002843)2.37777282
72Pulmonary infiltrates (HP:0002113)2.37079034
73Epistaxis (HP:0000421)2.33009485
74Joint swelling (HP:0001386)2.31288773
75Recurrent cutaneous fungal infections (HP:0011370)2.31105811
76Chronic mucocutaneous candidiasis (HP:0002728)2.31105811
77Abnormality of iron homeostasis (HP:0011031)2.30574575
78Peritonitis (HP:0002586)2.28962706
79Nuclear cataract (HP:0100018)2.26855475
80Chronic obstructive pulmonary disease (HP:0006510)2.25498431
81Obstructive lung disease (HP:0006536)2.25498431
82Hemoptysis (HP:0002105)2.24987763
83Hypergammaglobulinemia (HP:0010702)2.24577865
84Periodontitis (HP:0000704)2.23815253
85Keratoconjunctivitis sicca (HP:0001097)2.22637094
86Thin bony cortex (HP:0002753)2.21642722
87Episodic fever (HP:0001954)2.21543724
88Hypobetalipoproteinemia (HP:0003563)2.21413889
89Petechiae (HP:0000967)2.18743188
90Pulmonary embolism (HP:0002204)2.18394146
91Segmental peripheral demyelination/remyelination (HP:0003481)2.14458090
92IgA deficiency (HP:0002720)2.14031717
93Encephalitis (HP:0002383)2.13135185
94Abnormality of the pleura (HP:0002103)2.12640745
95Glomerulonephritis (HP:0000099)2.09929530
96Thrombophlebitis (HP:0004418)2.09257227
97Acne (HP:0001061)2.08301915
98Abnormality of glutamine family amino acid metabolism (HP:0010902)2.08283996
99Gastrointestinal stroma tumor (HP:0100723)2.07797795
100Amyloidosis (HP:0011034)2.07531089
101Abnormality of T cell number (HP:0011839)2.07045156
102Thrombocytosis (HP:0001894)2.06204403
103Abnormality of the pericardium (HP:0001697)2.05122554
104Cheilitis (HP:0100825)2.04335770
105Keratoconjunctivitis (HP:0001096)2.04321258
106Hepatosplenomegaly (HP:0001433)2.04264216
107Abnormality of transition element cation homeostasis (HP:0011030)2.04156461
108Purpura (HP:0000979)2.03045140
109Prolonged partial thromboplastin time (HP:0003645)2.02791613
110Skin ulcer (HP:0200042)2.02420345
111Hypochromic anemia (HP:0001931)2.00384075
112Abnormality of pyrimidine metabolism (HP:0004353)1.99867763
113Polycythemia (HP:0001901)1.99491726
114Hematochezia (HP:0002573)1.99414675
115Emphysema (HP:0002097)1.98807748
116Polygenic inheritance (HP:0010982)1.97413813
117Restrictive lung disease (HP:0002091)1.97143342
118Neurofibrillary tangles (HP:0002185)1.96624799
119Leukocytosis (HP:0001974)1.96565492
120Thoracic kyphosis (HP:0002942)1.96456943
121Premature loss of primary teeth (HP:0006323)1.96131209
122Progressive neurologic deterioration (HP:0002344)1.95412994
123T lymphocytopenia (HP:0005403)1.95160504
124Chest pain (HP:0100749)1.94936541
125Nephritis (HP:0000123)1.93506495
126Aplastic anemia (HP:0001915)1.93054417
127Glomerulopathy (HP:0100820)1.92474765
128Abnormal platelet volume (HP:0011876)1.91754564
129Arthralgia (HP:0002829)1.90125391
130Polyneuropathy (HP:0001271)1.89951628
131Abnormality of cells of the lymphoid lineage (HP:0012140)1.89638058
132Prolonged bleeding time (HP:0003010)1.88540301
133Hemorrhage of the eye (HP:0011885)1.88366686

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.88711226
2MAP4K13.74636292
3MAP3K143.15380883
4TYK22.99660139
5TBK12.94670701
6FGFR42.81408084
7PRPF4B2.66915059
8JAK32.59321455
9IRAK32.51718254
10BLK2.31865546
11EPHB12.19637375
12IKBKE2.17469198
13TXK2.10542676
14TAOK22.09956955
15IKBKB1.93635582
16IRAK41.90477005
17TRIB31.89694437
18MAP3K101.87461932
19JAK11.85166577
20EPHA31.84696679
21ZAP701.80158004
22CSK1.75781484
23CDK121.70394990
24PIM21.65409417
25GRK61.63430763
26CDC42BPA1.54612796
27STK101.53864935
28CHUK1.51906703
29KIT1.50605405
30GRK71.44679247
31BTK1.43394542
32RPS6KA41.43226191
33PKN21.42763287
34NME21.40463958
35DDR21.40237990
36TAOK31.32900806
37PIM11.29819637
38FGFR31.26257144
39CSF1R1.25956135
40FLT31.24405710
41HCK1.23422931
42MST41.20598442
43MAP2K31.20389681
44KDR1.16765840
45JAK21.14304367
46IRAK21.13436783
47RIPK41.11204677
48TGFBR21.10856108
49MATK1.10580706
50NLK1.10080197
51PTK61.09960121
52RIPK11.09401189
53SIK11.08885460
54MAP3K111.08526168
55LRRK21.07080166
56LCK1.06500522
57SYK1.05269928
58BMX1.02991280
59MAP3K131.00884261
60SMG10.96277679
61BMPR20.93508933
62MOS0.84507209
63ITK0.84500316
64PRKD20.83497383
65MARK20.81711678
66MAP3K30.80833119
67LYN0.79557264
68TEC0.79165640
69ALK0.77852553
70IRAK10.72329357
71EPHA20.72023218
72PDPK10.70283702
73CDK60.69999278
74MST1R0.69815638
75TESK10.69694991
76CDK40.66668116
77MARK30.63889801
78MAPK70.61038017
79PRKG20.60750668
80PDK10.60043637
81PAK40.59395707
82ICK0.58766150
83RPS6KL10.57765166
84RPS6KC10.57765166
85FGR0.56571418
86BCKDK0.55701873
87MAP2K20.55436925
88HIPK20.54411803
89KSR20.54075395
90MAP3K60.53745465
91MAP2K60.53362386
92EGFR0.51957795
93ABL20.51738803
94MAP3K10.50656518
95MAP3K80.50321627
96FES0.49046542
97EEF2K0.48823491
98SIK30.48664072
99MAPK110.47735015
100SIK20.46807371
101MAPKAPK20.45688256
102CDK70.44385782
103ABL10.44213305
104TESK20.42272567
105RPS6KA20.41982085
106MAP3K50.40506335
107TGFBR10.40312317
108PDGFRA0.39066732
109PRKCD0.38649524
110ERBB40.37760848
111RPS6KA60.36267519
112TAOK10.35787572
113FYN0.35775293
114MAPK40.35563587
115NEK20.34897726
116MAPK120.33247355
117NEK90.32460244
118TNK20.31673581
119PTK20.30788282
120RPS6KA10.30350763
121PDGFRB0.29774806
122ACVR1B0.29412054
123MTOR0.28871569
124CAMK1D0.27754425
125MAP3K70.24651202
126DYRK1B0.24519127
127TTN0.23194753

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.90476122
2Leishmaniasis_Homo sapiens_hsa051402.72361083
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.48879881
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.18434273
5Allograft rejection_Homo sapiens_hsa053302.13127207
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.99587327
7Intestinal immune network for IgA production_Homo sapiens_hsa046721.98025892
8Measles_Homo sapiens_hsa051621.97226431
9RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.96380795
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.95904270
11Osteoclast differentiation_Homo sapiens_hsa043801.92296039
12Legionellosis_Homo sapiens_hsa051341.88922707
13Asthma_Homo sapiens_hsa053101.85995401
14Primary bile acid biosynthesis_Homo sapiens_hsa001201.84283657
15Complement and coagulation cascades_Homo sapiens_hsa046101.83727262
16Graft-versus-host disease_Homo sapiens_hsa053321.81327396
17Primary immunodeficiency_Homo sapiens_hsa053401.77160470
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.76414608
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.73852531
20Malaria_Homo sapiens_hsa051441.70758818
21Caffeine metabolism_Homo sapiens_hsa002321.68821748
22B cell receptor signaling pathway_Homo sapiens_hsa046621.63892830
23Pertussis_Homo sapiens_hsa051331.56067388
24Arginine biosynthesis_Homo sapiens_hsa002201.55994235
25* TNF signaling pathway_Homo sapiens_hsa046681.54692589
26Antigen processing and presentation_Homo sapiens_hsa046121.54583636
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.50388716
28Influenza A_Homo sapiens_hsa051641.49724199
29Herpes simplex infection_Homo sapiens_hsa051681.48474678
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.46542267
31Toxoplasmosis_Homo sapiens_hsa051451.45554143
32Tuberculosis_Homo sapiens_hsa051521.27541282
33Nitrogen metabolism_Homo sapiens_hsa009101.25975193
34Acute myeloid leukemia_Homo sapiens_hsa052211.23371050
35African trypanosomiasis_Homo sapiens_hsa051431.23157211
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.22837738
37Hematopoietic cell lineage_Homo sapiens_hsa046401.22640373
38Apoptosis_Homo sapiens_hsa042101.16990064
39Shigellosis_Homo sapiens_hsa051311.16833081
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13544965
41Phagosome_Homo sapiens_hsa041451.09870472
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.08753343
43Sulfur relay system_Homo sapiens_hsa041221.08089855
44T cell receptor signaling pathway_Homo sapiens_hsa046601.07781157
45Tryptophan metabolism_Homo sapiens_hsa003801.07720522
46Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05768539
47Hepatitis C_Homo sapiens_hsa051601.05090270
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02516792
49Folate biosynthesis_Homo sapiens_hsa007901.01822673
50Hepatitis B_Homo sapiens_hsa051610.99136237
51Salmonella infection_Homo sapiens_hsa051320.91678936
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91586273
53VEGF signaling pathway_Homo sapiens_hsa043700.91365188
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.88953484
55Selenocompound metabolism_Homo sapiens_hsa004500.87626762
56Type I diabetes mellitus_Homo sapiens_hsa049400.87546622
57Bladder cancer_Homo sapiens_hsa052190.86113481
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85957566
59One carbon pool by folate_Homo sapiens_hsa006700.84587086
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82735189
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.81991136
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.80632815
63Chemokine signaling pathway_Homo sapiens_hsa040620.80362950
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79879796
65Histidine metabolism_Homo sapiens_hsa003400.78414679
66Autoimmune thyroid disease_Homo sapiens_hsa053200.76684582
67Chronic myeloid leukemia_Homo sapiens_hsa052200.72571290
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71577590
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71398305
70Notch signaling pathway_Homo sapiens_hsa043300.70234259
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68236574
72Viral myocarditis_Homo sapiens_hsa054160.65643841
73Chemical carcinogenesis_Homo sapiens_hsa052040.64829213
74PPAR signaling pathway_Homo sapiens_hsa033200.63115940
75Prolactin signaling pathway_Homo sapiens_hsa049170.63023784
76Pentose phosphate pathway_Homo sapiens_hsa000300.62574012
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.62511726
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60722774
79Epstein-Barr virus infection_Homo sapiens_hsa051690.60280732
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60159508
81Insulin resistance_Homo sapiens_hsa049310.59245840
82Amoebiasis_Homo sapiens_hsa051460.57904718
83Fructose and mannose metabolism_Homo sapiens_hsa000510.57868969
84Fat digestion and absorption_Homo sapiens_hsa049750.57606793
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.57540589
86Phenylalanine metabolism_Homo sapiens_hsa003600.57099359
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.56730126
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56568088
89Fatty acid degradation_Homo sapiens_hsa000710.55546958
90Viral carcinogenesis_Homo sapiens_hsa052030.54176423
91Lysosome_Homo sapiens_hsa041420.53482820
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53228509
93Small cell lung cancer_Homo sapiens_hsa052220.53203159
94Galactose metabolism_Homo sapiens_hsa000520.53132023
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52927559
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51870532
97Renal cell carcinoma_Homo sapiens_hsa052110.51703373
98Endocytosis_Homo sapiens_hsa041440.50602948
99ABC transporters_Homo sapiens_hsa020100.50040777
100Peroxisome_Homo sapiens_hsa041460.49445867
101Pancreatic cancer_Homo sapiens_hsa052120.48814285
102Rheumatoid arthritis_Homo sapiens_hsa053230.47872307
103Starch and sucrose metabolism_Homo sapiens_hsa005000.47108375
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46818277
105Other glycan degradation_Homo sapiens_hsa005110.45899916
106Non-small cell lung cancer_Homo sapiens_hsa052230.45403562
107Type II diabetes mellitus_Homo sapiens_hsa049300.42801155
108HIF-1 signaling pathway_Homo sapiens_hsa040660.42795808
109Prion diseases_Homo sapiens_hsa050200.42510775
110beta-Alanine metabolism_Homo sapiens_hsa004100.41606543
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.41413985
112Sphingolipid metabolism_Homo sapiens_hsa006000.39990352
113HTLV-I infection_Homo sapiens_hsa051660.39936251
114Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39776937
115Retinol metabolism_Homo sapiens_hsa008300.39744495
116FoxO signaling pathway_Homo sapiens_hsa040680.38969049
117Platelet activation_Homo sapiens_hsa046110.38207889
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37690432
119p53 signaling pathway_Homo sapiens_hsa041150.37509009
120GnRH signaling pathway_Homo sapiens_hsa049120.37079377
121Vitamin digestion and absorption_Homo sapiens_hsa049770.37003063
122Mineral absorption_Homo sapiens_hsa049780.33394527
123Renin-angiotensin system_Homo sapiens_hsa046140.32691259
124MAPK signaling pathway_Homo sapiens_hsa040100.32552538
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31835805
126SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31161497
127mTOR signaling pathway_Homo sapiens_hsa041500.29246555
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.26179530
129Insulin signaling pathway_Homo sapiens_hsa049100.25048343
130Sulfur metabolism_Homo sapiens_hsa009200.22159334
131Dorso-ventral axis formation_Homo sapiens_hsa043200.21897725

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