BCL6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of interleukin-8 biosynthetic process (GO:0045416)5.90701784
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.72512031
3negative regulation of cell killing (GO:0031342)5.72512031
4macrophage activation involved in immune response (GO:0002281)5.01430464
5detection of molecule of bacterial origin (GO:0032490)4.96050569
6regulation of cholesterol homeostasis (GO:2000188)4.94619646
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.88393003
8detection of other organism (GO:0098543)4.76870890
9response to peptidoglycan (GO:0032494)4.72364370
10neutrophil activation involved in immune response (GO:0002283)4.67566970
11cellular extravasation (GO:0045123)4.61303634
12positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.53860554
13detection of external biotic stimulus (GO:0098581)4.45580884
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.40162646
15detection of bacterium (GO:0016045)4.40074931
16regulation of cholesterol storage (GO:0010885)4.39598027
17positive regulation of lipoprotein lipase activity (GO:0051006)4.39592056
18positive regulation of triglyceride lipase activity (GO:0061365)4.39592056
19negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.38467734
20immunoglobulin mediated immune response (GO:0016064)4.28512740
21regulation of interleukin-8 biosynthetic process (GO:0045414)4.25489222
22positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610814.23381934
23positive regulation of triglyceride biosynthetic process (GO:0010867)4.20213740
24negative regulation of interleukin-12 production (GO:0032695)4.11797862
25leukocyte migration involved in inflammatory response (GO:0002523)4.07245430
26dicarboxylic acid biosynthetic process (GO:0043650)4.06542094
27positive regulation of toll-like receptor signaling pathway (GO:0034123)3.93656230
28regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.93330440
29regulation of gamma-delta T cell activation (GO:0046643)3.92956836
30detection of biotic stimulus (GO:0009595)3.91568279
31positive regulation of cholesterol efflux (GO:0010875)3.88797428
32leukocyte aggregation (GO:0070486)3.83597270
33neutrophil activation (GO:0042119)3.81709296
34macrophage activation (GO:0042116)3.80613398
35microglial cell activation (GO:0001774)3.72113976
36regulation of triglyceride biosynthetic process (GO:0010866)3.71603941
37response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.69000564
38response to host immune response (GO:0052572)3.69000564
39negative regulation of lipid storage (GO:0010888)3.67328710
40negative regulation of digestive system process (GO:0060457)3.66378129
41positive regulation of cholesterol transport (GO:0032376)3.65175705
42positive regulation of sterol transport (GO:0032373)3.65175705
43* negative regulation of lymphocyte mediated immunity (GO:0002707)3.64969310
44cell morphogenesis involved in neuron differentiation (GO:0048667)3.59391516
45apoptotic cell clearance (GO:0043277)3.57543088
46production of molecular mediator involved in inflammatory response (GO:0002532)3.54552202
47response to interleukin-15 (GO:0070672)3.54524302
48granulocyte activation (GO:0036230)3.54023345
49positive regulation of fatty acid biosynthetic process (GO:0045723)3.53938064
50neutrophil mediated immunity (GO:0002446)3.49473426
51negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.47071786
52response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.46451638
53response to host (GO:0075136)3.46451638
54response to host defenses (GO:0052200)3.46451638
55regulation of gamma-delta T cell differentiation (GO:0045586)3.40542619
56type I interferon signaling pathway (GO:0060337)3.36735358
57cellular response to type I interferon (GO:0071357)3.36735358
58respiratory burst (GO:0045730)3.36625949
59myeloid cell activation involved in immune response (GO:0002275)3.36245840
60regulation of mast cell degranulation (GO:0043304)3.36126910
61response to type I interferon (GO:0034340)3.35214970
62positive regulation of triglyceride metabolic process (GO:0090208)3.34241375
63* negative regulation of leukocyte mediated immunity (GO:0002704)3.28660809
64* negative regulation of B cell apoptotic process (GO:0002903)3.27332154
65fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.26115399
66regulation of myeloid leukocyte mediated immunity (GO:0002886)3.23390626
67positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.22046200
68response to muramyl dipeptide (GO:0032495)3.21580410
69regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.19378185
70negative regulation of T cell mediated immunity (GO:0002710)3.15958884
71lipopolysaccharide-mediated signaling pathway (GO:0031663)3.13971045
72positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.12296665
73regulation of mast cell activation involved in immune response (GO:0033006)3.07070089
74myeloid leukocyte mediated immunity (GO:0002444)3.06972850
75negative regulation of erythrocyte differentiation (GO:0045647)3.05873235
76regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.03283101
77regulation of triglyceride metabolic process (GO:0090207)3.03121207
78cellular response to interleukin-15 (GO:0071350)3.02271280
79regulation of leukocyte degranulation (GO:0043300)3.00770022
80B cell receptor signaling pathway (GO:0050853)2.99710204
81positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.99496567
82defense response to protozoan (GO:0042832)2.99456888
83interferon-gamma-mediated signaling pathway (GO:0060333)2.99162295
84triglyceride homeostasis (GO:0070328)2.96159780
85acylglycerol homeostasis (GO:0055090)2.96159780
86positive regulation of mast cell activation (GO:0033005)2.95428353
87* germinal center formation (GO:0002467)2.95250787
88neutrophil chemotaxis (GO:0030593)2.93322589
89regulation of mast cell activation (GO:0033003)2.90877957
90regulation of tolerance induction (GO:0002643)2.90835672
91antigen processing and presentation via MHC class Ib (GO:0002475)2.88305161
92negative regulation of toll-like receptor signaling pathway (GO:0034122)2.86423667
93positive regulation of interferon-alpha production (GO:0032727)2.85677266
94neutrophil migration (GO:1990266)2.85391021
95regulation of glycogen (starch) synthase activity (GO:2000465)2.83258390
96B cell mediated immunity (GO:0019724)2.83142250
97negative regulation of interleukin-6 production (GO:0032715)2.82619963
98urea cycle (GO:0000050)2.81371082
99urea metabolic process (GO:0019627)2.81371082
100alpha-linolenic acid metabolic process (GO:0036109)2.80583242
101NLS-bearing protein import into nucleus (GO:0006607)2.79240516
102regulation of dendritic cell antigen processing and presentation (GO:0002604)2.78818143
103regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.78343779
104response to food (GO:0032094)2.77623553
105regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.77297355
106* negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.77206929
107positive regulation by symbiont of host defense response (GO:0052509)2.76628782
108modulation by symbiont of host defense response (GO:0052031)2.76628782
109modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.76628782
110modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.76628782
111positive regulation by organism of defense response of other organism involved in symbiotic interact2.76628782
112modulation by symbiont of host immune response (GO:0052553)2.76628782
113negative regulation of innate immune response (GO:0045824)2.76297879
114positive regulation of type 2 immune response (GO:0002830)2.72173982
115regulation of interferon-alpha production (GO:0032647)2.71975898
116complement activation, alternative pathway (GO:0006957)2.71370900
117regulation of macrophage cytokine production (GO:0010935)2.70661803
118regulation of T cell tolerance induction (GO:0002664)2.70410704
119regulation of macrophage derived foam cell differentiation (GO:0010743)2.68830945
120L-amino acid import (GO:0043092)2.68204641
121T-helper 1 type immune response (GO:0042088)2.67811694
122positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.67267652
123response to protozoan (GO:0001562)2.65958494
124positive regulation of mast cell activation involved in immune response (GO:0033008)2.65097753
125positive regulation of mast cell degranulation (GO:0043306)2.65097753
126regulation of regulated secretory pathway (GO:1903305)2.64258288
127myeloid leukocyte activation (GO:0002274)2.63765572
128* regulation of T-helper 2 cell differentiation (GO:0045628)2.63720149
129positive regulation of fatty acid metabolic process (GO:0045923)2.62787854
130JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.61147998
131positive regulation of gamma-delta T cell activation (GO:0046645)2.60797350
132leukocyte degranulation (GO:0043299)2.59470872
133regulation of sequestering of triglyceride (GO:0010889)2.59459139
134regulation of interferon-beta biosynthetic process (GO:0045357)2.58551677
135low-density lipoprotein particle clearance (GO:0034383)2.57533738
136T cell apoptotic process (GO:0070231)2.57376855
137regulation of cholesterol efflux (GO:0010874)2.54421117
138glutamate metabolic process (GO:0006536)2.53233333
139regulation of membrane protein ectodomain proteolysis (GO:0051043)2.52654768
140nitrogen cycle metabolic process (GO:0071941)2.51532755
141negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.51500342
142peptidyl-glutamic acid carboxylation (GO:0017187)2.51334426
143protein carboxylation (GO:0018214)2.51334426
144C4-dicarboxylate transport (GO:0015740)2.49967177
145triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.48031736
146regulation of B cell receptor signaling pathway (GO:0050855)2.46637710
147regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.40458000
148tryptophan catabolic process (GO:0006569)2.40296790
149indole-containing compound catabolic process (GO:0042436)2.40296790
150indolalkylamine catabolic process (GO:0046218)2.40296790
151plasma lipoprotein particle clearance (GO:0034381)2.40189919
152kynurenine metabolic process (GO:0070189)2.39245054
153regulation of T cell receptor signaling pathway (GO:0050856)2.39141755
154carnitine metabolic process (GO:0009437)2.38692397
155regulation of lipid storage (GO:0010883)2.37820268
156cellular defense response (GO:0006968)2.36411590
157positive regulation of cellular amide metabolic process (GO:0034250)2.36082695
158amino-acid betaine metabolic process (GO:0006577)2.35168585
159aromatic amino acid family catabolic process (GO:0009074)2.34616472
160pyrimidine ribonucleoside catabolic process (GO:0046133)2.34469095
161growth hormone receptor signaling pathway (GO:0060396)2.34394894
162negative regulation of stress fiber assembly (GO:0051497)2.33995661
163positive regulation of fatty acid beta-oxidation (GO:0032000)2.33724762
164erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.33235580
165L-phenylalanine catabolic process (GO:0006559)2.33235580
166regulation of toll-like receptor signaling pathway (GO:0034121)2.32880195
167regulation of protein activation cascade (GO:2000257)2.32311838
168* regulation of B cell apoptotic process (GO:0002902)2.31520710
169antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.31496599
170tryptophan metabolic process (GO:0006568)2.30947615
171membrane tubulation (GO:0097320)2.30755922
172cytidine deamination (GO:0009972)2.30728913
173cytidine metabolic process (GO:0046087)2.30728913
174cytidine catabolic process (GO:0006216)2.30728913
175antigen processing and presentation of endogenous antigen (GO:0019883)2.30368791
176response to fungus (GO:0009620)2.30112018
177bile acid biosynthetic process (GO:0006699)2.29672449
178phospholipid homeostasis (GO:0055091)2.29375633
179desmosome organization (GO:0002934)2.28480120
180negative regulation of lipid transport (GO:0032369)2.26507544
181regulation of complement activation (GO:0030449)2.25884604
182I-kappaB phosphorylation (GO:0007252)2.25082246
183positive regulation of p38MAPK cascade (GO:1900745)2.24890761
184cytokine biosynthetic process (GO:0042089)2.22899022

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.79662074
2* ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.62639263
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.98141020
4* RXR_22158963_ChIP-Seq_LIVER_Mouse2.84571694
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.79465964
6* LXR_22158963_ChIP-Seq_LIVER_Mouse2.48989739
7* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.45125245
8* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.35335273
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.35300818
10* FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.27782020
11* VDR_24763502_ChIP-Seq_THP-1_Human2.21569413
12* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.09151732
13VDR_21846776_ChIP-Seq_THP-1_Human2.07662381
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.06809901
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.01887195
16* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.99400120
17* IRF8_27001747_Chip-Seq_BMDM_Mouse1.96942316
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.91451669
19EGR1_23403033_ChIP-Seq_LIVER_Mouse1.90440775
20TP63_17297297_ChIP-ChIP_HaCaT_Human1.89766944
21SPI1_23547873_ChIP-Seq_NB4_Human1.88654340
22RUNX1_22412390_ChIP-Seq_EML_Mouse1.88414120
23* FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.87799506
24SCL_19346495_ChIP-Seq_HPC-7_Human1.83302909
25BP1_19119308_ChIP-ChIP_Hs578T_Human1.82988317
26* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77517447
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.77210631
28* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.73148480
29RUNX_20019798_ChIP-Seq_JUKART_Human1.70545319
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.68466019
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64454572
32UTX_26944678_Chip-Seq_JUKART_Human1.60916574
33RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.56725143
34* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.55759209
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54017898
36MYC_22102868_ChIP-Seq_BL_Human1.50773905
37* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.50710845
38* VDR_24787735_ChIP-Seq_THP-1_Human1.50032829
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.43425610
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.43357602
41LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.38950039
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38400746
43* MYB_26560356_Chip-Seq_TH1_Human1.38154828
44TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.37658687
45* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37209356
46* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.33885415
47MAF_26560356_Chip-Seq_TH2_Human1.32284624
48TRIM28_21343339_ChIP-Seq_HEK293_Human1.31737244
49* GATA3_27048872_Chip-Seq_THYMUS_Human1.31465434
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30583557
51ELK3_25401928_ChIP-Seq_HUVEC_Human1.29580110
52* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25495929
53ESR1_20079471_ChIP-ChIP_T-47D_Human1.24940526
54GATA1_19941826_ChIP-Seq_K562_Human1.22794263
55DROSHA_22980978_ChIP-Seq_HELA_Human1.21044918
56PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19979057
57* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.17414253
58GATA2_21666600_ChIP-Seq_HMVEC_Human1.16595102
59GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16504368
60* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16328562
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16276619
62* KDM2B_26808549_Chip-Seq_JURKAT_Human1.15030266
63TP53_16413492_ChIP-PET_HCT116_Human1.14656592
64AR_21572438_ChIP-Seq_LNCaP_Human1.14611712
65* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14273169
66GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13930613
67NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.13539399
68MAF_26560356_Chip-Seq_TH1_Human1.13437470
69* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.12878947
70MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.12828304
71* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.12589638
72GATA1_22025678_ChIP-Seq_K562_Human1.12245447
73CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12015047
74* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11412522
75PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11367711
76GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10962780
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.10066891
78* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.09055973
79ESR1_21235772_ChIP-Seq_MCF-7_Human1.07813722
80RXR_22108803_ChIP-Seq_LS180_Human1.07686138
81CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07420796
82CJUN_26792858_Chip-Seq_BT549_Human1.06232843
83SPI1_23127762_ChIP-Seq_K562_Human1.06081208
84CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05523489
85* FOXA2_19822575_ChIP-Seq_HepG2_Human1.05486026
86FOXO3_23340844_ChIP-Seq_DLD1_Human1.04275700
87STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03916329
88MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03858488
89* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03705336
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02504909
91* CLOCK_20551151_ChIP-Seq_293T_Human1.02147817
92SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01431833
93* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01283590
94* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00628902
95TP53_18474530_ChIP-ChIP_U2OS_Human1.00490122
96EP300_21415370_ChIP-Seq_HL-1_Mouse1.00346328
97* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99831013
98* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99831013
99TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99589217
100E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99374621
101SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96977843
102* LXR_22292898_ChIP-Seq_THP-1_Human0.95866456
103IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.95626987
104GATA1_19941827_ChIP-Seq_MEL_Mouse0.95145893
105TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.94829200
106EGR1_19032775_ChIP-ChIP_M12_Human0.94781702
107PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94770647
108VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94402595
109GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93936571
110TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.93616523
111* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93255191
112* TBX20_22328084_ChIP-Seq_HEART_Mouse0.93105950
113* TBX20_22080862_ChIP-Seq_HEART_Mouse0.93105950
114RACK7_27058665_Chip-Seq_MCF-7_Human0.92847003
115GATA3_26560356_Chip-Seq_TH2_Human0.92088293
116BRD4_27068464_Chip-Seq_AML-cells_Mouse0.92083495
117GATA2_19941826_ChIP-Seq_K562_Human0.91140949
118* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91076502
119LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90964437
120* PU_27001747_Chip-Seq_BMDM_Mouse0.90338803
121* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.88948121
122EZH2_22144423_ChIP-Seq_EOC_Human0.87190220
123PU.1_20513432_ChIP-Seq_Bcells_Mouse0.86936419
124CDX2_20551321_ChIP-Seq_CACO-2_Human0.86384602
125* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.86372718
126SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.85926068
127NFIB_24661679_ChIP-Seq_LUNG_Mouse0.85565981
128* MYB_26560356_Chip-Seq_TH2_Human0.85481560
129EGR1_19374776_ChIP-ChIP_THP-1_Human0.84200289
130IKZF1_21737484_ChIP-ChIP_HCT116_Human0.84184366
131CTCF_27219007_Chip-Seq_ERYTHROID_Human0.84070173
132CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.83785464
133TCF7_22412390_ChIP-Seq_EML_Mouse0.83699874
134* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.83167168
135GATA1_19941827_ChIP-Seq_MEL86_Mouse0.81885006
136ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81436282
137* KDM2B_26808549_Chip-Seq_DND41_Human0.81012865
138* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.80368627
139CTNNB1_20460455_ChIP-Seq_HCT116_Human0.78979780
140* KDM2B_26808549_Chip-Seq_K562_Human0.78274374

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.78660784
2MP0003191_abnormal_cellular_cholesterol4.59989084
3MP0005365_abnormal_bile_salt3.60591393
4MP0005360_urolithiasis2.82792472
5MP0003329_amyloid_beta_deposits2.40309328
6MP0000604_amyloidosis2.34071340
7MP0001835_abnormal_antigen_presentation2.09342441
8MP0003303_peritoneal_inflammation2.06154864
9MP0004130_abnormal_muscle_cell2.03657811
10MP0003436_decreased_susceptibility_to2.02241993
11MP0010329_abnormal_lipoprotein_level1.98922399
12MP0003828_pulmonary_edema1.98106028
13MP0008260_abnormal_autophagy1.97044523
14MP0004510_myositis1.95049114
15MP0003724_increased_susceptibility_to1.94322854
16* MP0005387_immune_system_phenotype1.93572403
17* MP0001790_abnormal_immune_system1.93572403
18MP0009278_abnormal_bone_marrow1.87318646
19MP0002132_abnormal_respiratory_system1.86590791
20MP0003252_abnormal_bile_duct1.85453478
21MP0005085_abnormal_gallbladder_physiolo1.82159895
22MP0008875_abnormal_xenobiotic_pharmacok1.76137869
23* MP0001800_abnormal_humoral_immune1.70444064
24MP0002138_abnormal_hepatobiliary_system1.65153826
25MP0003300_gastrointestinal_ulcer1.63531154
26MP0004145_abnormal_muscle_electrophysio1.63516426
27MP0002254_reproductive_system_inflammat1.62560589
28MP0003763_abnormal_thymus_physiology1.61261891
29MP0009785_altered_susceptibility_to1.57573862
30MP0003646_muscle_fatigue1.55440371
31MP0004883_abnormal_blood_vessel1.50389345
32MP0002419_abnormal_innate_immunity1.49910238
33MP0005025_abnormal_response_to1.46884720
34MP0009840_abnormal_foam_cell1.45149616
35* MP0002398_abnormal_bone_marrow1.44013692
36MP0005164_abnormal_response_to1.42620592
37MP0000465_gastrointestinal_hemorrhage1.42353249
38MP0005000_abnormal_immune_tolerance1.42003527
39MP0004381_abnormal_hair_follicle1.39763733
40MP0005670_abnormal_white_adipose1.38655813
41MP0003075_altered_response_to1.36662047
42* MP0000685_abnormal_immune_system1.36615183
43MP0002277_abnormal_respiratory_mucosa1.35939637
44MP0005671_abnormal_response_to1.34619607
45* MP0000609_abnormal_liver_physiology1.33909388
46* MP0002452_abnormal_antigen_presenting1.31800204
47MP0008004_abnormal_stomach_pH1.31447656
48* MP0002723_abnormal_immune_serum1.30919698
49MP0004947_skin_inflammation1.30842615
50MP0005083_abnormal_biliary_tract1.29760381
51MP0006082_CNS_inflammation1.26781172
52* MP0008469_abnormal_protein_level1.26115434
53MP0005397_hematopoietic_system_phenotyp1.25228107
54MP0001545_abnormal_hematopoietic_system1.25228107
55MP0000858_altered_metastatic_potential1.24505769
56MP0003195_calcinosis1.24147385
57MP0002332_abnormal_exercise_endurance1.23858344
58MP0005332_abnormal_amino_acid1.22996173
59MP0000751_myopathy1.22819268
60MP0009764_decreased_sensitivity_to1.21768935
61MP0003866_abnormal_defecation1.20587780
62MP0002118_abnormal_lipid_homeostasis1.19537680
63MP0005647_abnormal_sex_gland1.19010051
64MP0000747_muscle_weakness1.18460207
65MP0005319_abnormal_enzyme/_coenzyme1.17395257
66MP0002837_dystrophic_cardiac_calcinosis1.16784685
67* MP0002722_abnormal_immune_system1.16522644
68MP0005310_abnormal_salivary_gland1.16453524
69MP0002971_abnormal_brown_adipose1.16443849
70MP0001533_abnormal_skeleton_physiology1.15304642
71MP0002429_abnormal_blood_cell1.13449038
72MP0005584_abnormal_enzyme/coenzyme_acti1.11091816
73MP0003690_abnormal_glial_cell1.10255661
74MP0002148_abnormal_hypersensitivity_rea1.09701972
75MP0005666_abnormal_adipose_tissue1.09596431
76MP0009333_abnormal_splenocyte_physiolog1.08207684
77MP0005058_abnormal_lysosome_morphology1.07856516
78MP0005167_abnormal_blood-brain_barrier1.05896748
79MP0003183_abnormal_peptide_metabolism1.03733555
80* MP0002420_abnormal_adaptive_immunity1.03494214
81MP0002933_joint_inflammation1.03475495
82* MP0001819_abnormal_immune_cell1.03471110
83MP0002166_altered_tumor_susceptibility1.02332644
84MP0005451_abnormal_body_composition1.02042048
85* MP0001853_heart_inflammation1.00984497
86MP0003045_fibrosis1.00877261
87MP0003705_abnormal_hypodermis_morpholog0.99351946
88MP0008961_abnormal_basal_metabolism0.98129594
89* MP0001845_abnormal_inflammatory_respons0.97520670
90MP0003656_abnormal_erythrocyte_physiolo0.96999243
91MP0005390_skeleton_phenotype0.94958086
92MP0004185_abnormal_adipocyte_glucose0.93705817
93MP0002396_abnormal_hematopoietic_system0.93680592
94MP0003448_altered_tumor_morphology0.93496828
95MP0003091_abnormal_cell_migration0.91586648
96MP0000749_muscle_degeneration0.91032827
97MP0000343_altered_response_to0.90441816
98* MP0000703_abnormal_thymus_morphology0.89488079
99MP0009763_increased_sensitivity_to0.88691648
100MP0001986_abnormal_taste_sensitivity0.86266976
101MP0000759_abnormal_skeletal_muscle0.85139929
102MP0005464_abnormal_platelet_physiology0.84653054
103* MP0004087_abnormal_muscle_fiber0.83976486
104MP0001958_emphysema0.83444944
105MP0005166_decreased_susceptibility_to0.81953872
106MP0003172_abnormal_lysosome_physiology0.81463562
107MP0003806_abnormal_nucleotide_metabolis0.80690897
108MP0005379_endocrine/exocrine_gland_phen0.80324288
109MP0002998_abnormal_bone_remodeling0.79990972
110MP0004484_altered_response_of0.79400937
111MP0005076_abnormal_cell_differentiation0.78615541
112MP0005535_abnormal_body_temperature0.77734415
113MP0003453_abnormal_keratinocyte_physiol0.76276401
114MP0000383_abnormal_hair_follicle0.75912234
115MP0003566_abnormal_cell_adhesion0.75776894
116MP0000920_abnormal_myelination0.72639365
117MP0010155_abnormal_intestine_physiology0.71694014
118MP0000716_abnormal_immune_system0.71178415
119MP0002006_tumorigenesis0.71167706
120MP0000249_abnormal_blood_vessel0.70259793
121MP0005375_adipose_tissue_phenotype0.69624599
122MP0002106_abnormal_muscle_physiology0.69221561
123MP0002060_abnormal_skin_morphology0.68531594
124MP0008874_decreased_physiological_sensi0.68355249
125MP0003795_abnormal_bone_structure0.68059305
126MP0003279_aneurysm0.66346480
127MP0004858_abnormal_nervous_system0.65104073
128MP0001851_eye_inflammation0.64970261
129MP0002133_abnormal_respiratory_system0.64904897
130MP0005388_respiratory_system_phenotype0.64904897
131MP0003221_abnormal_cardiomyocyte_apopto0.64866001
132* MP0002405_respiratory_system_inflammati0.64528566
133* MP0000689_abnormal_spleen_morphology0.63485730
134MP0001663_abnormal_digestive_system0.63471959
135MP0005275_abnormal_skin_tensile0.62674656
136MP0009765_abnormal_xenobiotic_induced0.62671313
137MP0009115_abnormal_fat_cell0.62310041
138MP0004019_abnormal_vitamin_homeostasis0.61937160
139MP0002796_impaired_skin_barrier0.61432108

Predicted human phenotypes

RankGene SetZ-score
1Retrobulbar optic neuritis (HP:0100654)5.23813019
2Optic neuritis (HP:0100653)5.23813019
3Complement deficiency (HP:0004431)4.21788255
4Recurrent gram-negative bacterial infections (HP:0005420)3.94265645
5Keratoconjunctivitis sicca (HP:0001097)3.87840307
6Systemic lupus erythematosus (HP:0002725)3.70261272
7Hemiplegia (HP:0002301)3.65961058
8Increased IgE level (HP:0003212)3.57394747
9Keratoconjunctivitis (HP:0001096)3.53635645
10Autoimmune thrombocytopenia (HP:0001973)3.48762036
11Spontaneous hematomas (HP:0007420)3.45039191
12Abnormality of complement system (HP:0005339)3.42866486
13Myocardial infarction (HP:0001658)3.27115132
14Eczematoid dermatitis (HP:0000976)3.22443733
15Deep venous thrombosis (HP:0002625)3.18495106
16Abnormal delayed hypersensitivity skin test (HP:0002963)3.16491446
17Encephalitis (HP:0002383)3.13755406
18Xanthomatosis (HP:0000991)3.09702942
19Parakeratosis (HP:0001036)3.08380679
20Peritonitis (HP:0002586)3.05443332
21Fatigable weakness (HP:0003473)3.03280981
22Abnormality of the neuromuscular junction (HP:0003398)3.03280981
23Recurrent cutaneous fungal infections (HP:0011370)2.98033447
24Chronic mucocutaneous candidiasis (HP:0002728)2.98033447
25Chest pain (HP:0100749)2.94416093
26Recurrent abscess formation (HP:0002722)2.92975516
27Urticaria (HP:0001025)2.92851131
28Hemoptysis (HP:0002105)2.91717792
29Episodic fever (HP:0001954)2.89849689
30Arterial thrombosis (HP:0004420)2.82923734
31Abnormality of the parathyroid morphology (HP:0011766)2.80578045
32Pulmonary infiltrates (HP:0002113)2.79309653
33Prolonged bleeding time (HP:0003010)2.74894232
34Gingivitis (HP:0000230)2.74826596
35Right ventricular cardiomyopathy (HP:0011663)2.73770367
36Abnormality of the common coagulation pathway (HP:0010990)2.72388912
37Muscle fiber splitting (HP:0003555)2.69879596
38Hypochromic microcytic anemia (HP:0004840)2.69704200
39Abnormality of placental membranes (HP:0011409)2.64633143
40Amniotic constriction ring (HP:0009775)2.64633143
41Pulmonary embolism (HP:0002204)2.63899527
42Exercise-induced myalgia (HP:0003738)2.63821780
43Recurrent bacterial skin infections (HP:0005406)2.58840967
44Amyloidosis (HP:0011034)2.58726798
45Glomerulonephritis (HP:0000099)2.58637250
46Prolonged partial thromboplastin time (HP:0003645)2.53076197
47Joint hemorrhage (HP:0005261)2.51447967
48Hyperlipoproteinemia (HP:0010980)2.51403526
49Hypochromic anemia (HP:0001931)2.50411866
50Gangrene (HP:0100758)2.44504257
51Abnormality of glutamine family amino acid metabolism (HP:0010902)2.43774608
52Anorexia (HP:0002039)2.42894287
53Abnormality of the endocardium (HP:0004306)2.41174778
54Inflammation of the large intestine (HP:0002037)2.40686699
55Humeroradial synostosis (HP:0003041)2.39119041
56Synostosis involving the elbow (HP:0003938)2.39119041
57Nephritis (HP:0000123)2.37083400
58Epistaxis (HP:0000421)2.33565035
59Leukocytosis (HP:0001974)2.32266478
60Stomatitis (HP:0010280)2.31850128
61Gastrointestinal inflammation (HP:0004386)2.31261916
62Osteomyelitis (HP:0002754)2.29876036
63Hyperglycinuria (HP:0003108)2.27870369
64T lymphocytopenia (HP:0005403)2.26952113
65Intrahepatic cholestasis (HP:0001406)2.26947670
66Mitral stenosis (HP:0001718)2.23743793
67Severe combined immunodeficiency (HP:0004430)2.21783537
68Abnormality of monocarboxylic acid metabolism (HP:0010996)2.21409064
69Segmental peripheral demyelination/remyelination (HP:0003481)2.20665441
70Type 1 muscle fiber predominance (HP:0003803)2.20170108
71Nasal polyposis (HP:0100582)2.19789463
72Abnormality of T cell number (HP:0011839)2.18208233
73Vertigo (HP:0002321)2.16403483
74Weak cry (HP:0001612)2.15055198
75Hyporeflexia of lower limbs (HP:0002600)2.14501256
76Renal cell carcinoma (HP:0005584)2.14248068
77Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.12885494
78Hypoalphalipoproteinemia (HP:0003233)2.11936416
79* Mediastinal lymphadenopathy (HP:0100721)2.10140087
80Colitis (HP:0002583)2.07932857
81Agammaglobulinemia (HP:0004432)2.07846906
82Epidermoid cyst (HP:0200040)2.07771059
83Type 2 muscle fiber atrophy (HP:0003554)2.05242692
84Obstructive lung disease (HP:0006536)2.05108072
85Chronic obstructive pulmonary disease (HP:0006510)2.05108072
86Acne (HP:0001061)2.04308908
87Abnormality of fatty-acid metabolism (HP:0004359)2.03615102
88Purpura (HP:0000979)2.03283555
89Recurrent fungal infections (HP:0002841)2.02787886
90Pustule (HP:0200039)2.02764430
91Slow saccadic eye movements (HP:0000514)2.01715164
92Hemiparesis (HP:0001269)2.01604627
93Abnormality of the nasal mucosa (HP:0000433)2.00966573
94Sepsis (HP:0100806)2.00803724
95Gastrointestinal infarctions (HP:0005244)2.00197741
96Abnormality of glycolipid metabolism (HP:0010969)1.99622143
97Abnormality of liposaccharide metabolism (HP:0010968)1.99622143
98Abnormality of glycosphingolipid metabolism (HP:0004343)1.99622143
99Thick nail (HP:0001805)1.99039346
100Chronic otitis media (HP:0000389)1.98767923
101Elevated erythrocyte sedimentation rate (HP:0003565)1.98748981
102Ketosis (HP:0001946)1.98574537
103* Abnormality of the pleura (HP:0002103)1.98314706
104Loss of speech (HP:0002371)1.97496160
105Exercise-induced muscle cramps (HP:0003710)1.97132009
106Axonal loss (HP:0003447)1.96497996
107Hyperammonemia (HP:0001987)1.95580340
108Polycythemia (HP:0001901)1.95128427
109Abnormality of aromatic amino acid family metabolism (HP:0004338)1.94948199
110Asymmetric septal hypertrophy (HP:0001670)1.94508176
111Abnormality of macrophages (HP:0004311)1.94437925
112Gastrointestinal stroma tumor (HP:0100723)1.94306513
113Combined immunodeficiency (HP:0005387)1.94072445
114Hypergammaglobulinemia (HP:0010702)1.93575125
115Increased connective tissue (HP:0009025)1.92985031
116Vasculitis (HP:0002633)1.92970234
117Glomerulopathy (HP:0100820)1.91994919
118Increased serum ferritin (HP:0003281)1.91263959
119Abnormality of proline metabolism (HP:0010907)1.90506023
120Hydroxyprolinuria (HP:0003080)1.90506023
121Joint swelling (HP:0001386)1.88225901
122Microcytic anemia (HP:0001935)1.86363809
123Hypercholesterolemia (HP:0003124)1.86048728
124Lower limb amyotrophy (HP:0007210)1.85458353
125Recurrent bronchitis (HP:0002837)1.85367048
126Muscle fiber inclusion bodies (HP:0100299)1.84825523
127Recurrent skin infections (HP:0001581)1.84391670
128Granulocytopenia (HP:0001913)1.83948307
129Keratitis (HP:0000491)1.83398326
130Nonprogressive disorder (HP:0003680)1.83184252
131Abnormality of the pericardium (HP:0001697)1.83114587
132Dysostosis multiplex (HP:0000943)1.83017695
133Muscle fiber atrophy (HP:0100295)1.82964812
134* Meningitis (HP:0001287)1.82778509
135Polyneuropathy (HP:0001271)1.82038109
136Metaphyseal cupping (HP:0003021)1.81731528
137Broad metatarsal (HP:0001783)1.81622025
138Abnormality of iron homeostasis (HP:0011031)1.80968242
139Pancreatitis (HP:0001733)1.80967458
140Gingival bleeding (HP:0000225)1.79811586
141Increased cerebral lipofuscin (HP:0011813)1.79766688
142Increased IgM level (HP:0003496)1.79661047
143Upper limb muscle weakness (HP:0003484)1.79384567
144Vascular calcification (HP:0004934)1.79266050
145Increased CSF protein (HP:0002922)1.79239606
146Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.78316276
147Skin ulcer (HP:0200042)1.78181521
148Obstructive sleep apnea (HP:0002870)1.77888275
149Esophageal varix (HP:0002040)1.77793639
150Abnormality of skeletal muscle fiber size (HP:0012084)1.77455835
151Ketoacidosis (HP:0001993)1.76942973
152Atrophic scars (HP:0001075)1.76915156
153Difficulty running (HP:0009046)1.76798641
154Ventricular fibrillation (HP:0001663)1.76680358
155Abnormality of T cells (HP:0002843)1.76344847
156Orchitis (HP:0100796)1.75754028
157Increased variability in muscle fiber diameter (HP:0003557)1.75415029
158Cellulitis (HP:0100658)1.74487638
159Cardiovascular calcification (HP:0011915)1.73723820
160Subacute progressive viral hepatitis (HP:0006572)1.73696561
161Abnormality of binocular vision (HP:0011514)1.73610497
162Diplopia (HP:0000651)1.73610497
163Status epilepticus (HP:0002133)1.72184424
164Round ear (HP:0100830)1.71617614
165Myositis (HP:0100614)1.70809161
166Interstitial pulmonary disease (HP:0006530)1.70752847
167Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.70178065
168Recurrent viral infections (HP:0004429)1.70124279
169Abnormality of T cell physiology (HP:0011840)1.69623829

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK4.56127905
2MAP3K133.09256738
3ERN12.75361184
4MAP3K142.55895180
5GRK12.47876648
6MAP3K92.45930096
7MAP4K12.39734860
8RIPK42.31708651
9IKBKB2.15613934
10TRIB32.07099956
11TYK22.06990856
12PRPF4B2.02275602
13TNK22.00662444
14MAP3K71.83549840
15SIK11.82729103
16FGFR41.77445802
17JAK11.74674482
18TTN1.67110503
19TAOK31.60075956
20PTK61.58022651
21TBK11.57614108
22KSR21.53565244
23EPHB11.52211727
24NTRK31.50068205
25BLK1.48446040
26MAP3K111.42048868
27RIPK11.39742514
28PRKCH1.24336919
29IRAK31.22503704
30TGFBR21.19316587
31TAOK11.17091261
32MAP3K61.15199596
33IRAK41.13936862
34KIT1.13000099
35IKBKE1.11269390
36JAK31.08761117
37FGFR31.08725379
38TXK1.07235373
39PIK3CG1.06414384
40CSK1.05161401
41MAP2K31.04831975
42OBSCN1.02122721
43IRAK21.02017258
44MAP3K21.01994071
45CAMK1D1.00830094
46SGK31.00323045
47IRAK10.95371433
48SIK30.94152348
49CDC42BPA0.94038464
50JAK20.92829027
51YES10.92798660
52PIK3CA0.92075079
53PRKAA20.90630408
54HCK0.90401564
55PRKCQ0.90284895
56CAMK1G0.90079542
57CSF1R0.89941520
58MAP3K30.88749909
59MAP3K10.86805317
60BMX0.86764745
61MAPK70.86163748
62DMPK0.85354310
63MST1R0.84597094
64SYK0.84195851
65CHUK0.83035993
66PKN20.81308397
67MARK30.80969143
68MATK0.78095730
69MAPK120.78001488
70DAPK20.75519520
71PHKG20.75083875
72PHKG10.75083875
73BTK0.74785503
74EPHA30.74648028
75SGK20.74193182
76BMPR20.73588765
77SGK10.71836473
78ITK0.70408823
79MAP2K40.69386942
80MAPK150.66655264
81SIK20.66298744
82BCKDK0.64915147
83PRKD20.62450971
84PTK2B0.62380526
85WNK10.60654101
86DYRK1B0.60501754
87MST40.60232663
88SMG10.60190141
89GRK60.59650468
90HIPK20.59516597
91ZAP700.58630791
92PRKD10.58003747
93MAP2K60.57810138
94FES0.56526586
95LRRK20.55963555
96STK110.55384821
97LCK0.54601443
98GRK70.53551800
99CAMK40.52894942
100MOS0.52871569
101FGR0.52405229
102FYN0.52151385
103CAMKK10.51654639
104NEK90.51531116
105STK380.51247340
106STK100.50970661
107INSRR0.50083444
108PDK10.48474359
109NLK0.48210821
110KSR10.48100449
111MAPK110.48040023
112TEC0.46971789
113ROCK10.45884963
114RAF10.45690756
115PDGFRB0.45585520
116TNIK0.45201508
117PDPK10.44947376
118CAMKK20.44623842
119IGF1R0.44034422
120RET0.43541601
121SGK4940.43468962
122SGK2230.43468962
123RPS6KL10.42904410
124RPS6KC10.42904410
125TAOK20.42710912
126CDK60.41455709
127MARK20.40723897
128MAP3K100.39507464
129LYN0.39349404
130PRKCE0.38838797
131MAPKAPK20.38373480
132MAP3K50.38110113

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.49016884
2Staphylococcus aureus infection_Homo sapiens_hsa051502.74332085
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.58171918
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.37741517
5PPAR signaling pathway_Homo sapiens_hsa033202.03015935
6Arginine biosynthesis_Homo sapiens_hsa002201.98361962
7Complement and coagulation cascades_Homo sapiens_hsa046101.96460370
8B cell receptor signaling pathway_Homo sapiens_hsa046621.87894119
9Fatty acid degradation_Homo sapiens_hsa000711.85297066
10Graft-versus-host disease_Homo sapiens_hsa053321.77286952
11Allograft rejection_Homo sapiens_hsa053301.71785602
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.58983343
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.56137055
14Autoimmune thyroid disease_Homo sapiens_hsa053201.53323964
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.50880384
16Osteoclast differentiation_Homo sapiens_hsa043801.49155158
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.45261864
18ABC transporters_Homo sapiens_hsa020101.41732178
19Caffeine metabolism_Homo sapiens_hsa002321.41727934
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40772413
21Leishmaniasis_Homo sapiens_hsa051401.40486824
22Fatty acid metabolism_Homo sapiens_hsa012121.28707851
23Tryptophan metabolism_Homo sapiens_hsa003801.27032095
24Phagosome_Homo sapiens_hsa041451.24969099
25Insulin resistance_Homo sapiens_hsa049311.21824370
26Other glycan degradation_Homo sapiens_hsa005111.21477895
27Propanoate metabolism_Homo sapiens_hsa006401.20295802
28Type I diabetes mellitus_Homo sapiens_hsa049401.20245195
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.17611921
30beta-Alanine metabolism_Homo sapiens_hsa004101.16841539
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.15756347
32Butanoate metabolism_Homo sapiens_hsa006501.12972968
33Viral myocarditis_Homo sapiens_hsa054161.12469481
34Bile secretion_Homo sapiens_hsa049761.11337563
35Non-small cell lung cancer_Homo sapiens_hsa052231.10263467
36Tuberculosis_Homo sapiens_hsa051521.09534686
37Primary immunodeficiency_Homo sapiens_hsa053401.08773241
38Antigen processing and presentation_Homo sapiens_hsa046121.08693103
39Pertussis_Homo sapiens_hsa051331.07854623
40T cell receptor signaling pathway_Homo sapiens_hsa046601.02246268
41Adipocytokine signaling pathway_Homo sapiens_hsa049201.01964910
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01930611
43Herpes simplex infection_Homo sapiens_hsa051681.01110324
44Hepatitis B_Homo sapiens_hsa051610.98949214
45Prolactin signaling pathway_Homo sapiens_hsa049170.96444483
46Chemokine signaling pathway_Homo sapiens_hsa040620.94813679
47Starch and sucrose metabolism_Homo sapiens_hsa005000.93002312
48Peroxisome_Homo sapiens_hsa041460.91774108
49Malaria_Homo sapiens_hsa051440.91257421
50Pancreatic cancer_Homo sapiens_hsa052120.90168376
51Rheumatoid arthritis_Homo sapiens_hsa053230.89933906
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.89367982
53Type II diabetes mellitus_Homo sapiens_hsa049300.88696875
54Renal cell carcinoma_Homo sapiens_hsa052110.88580117
55Chronic myeloid leukemia_Homo sapiens_hsa052200.88109472
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.87218830
57Notch signaling pathway_Homo sapiens_hsa043300.87109666
58GnRH signaling pathway_Homo sapiens_hsa049120.83944211
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82024701
60Toxoplasmosis_Homo sapiens_hsa051450.81774629
61TNF signaling pathway_Homo sapiens_hsa046680.81762549
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.81204343
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80789338
64Influenza A_Homo sapiens_hsa051640.77607810
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75742584
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74765629
67Choline metabolism in cancer_Homo sapiens_hsa052310.74439918
68Lysine degradation_Homo sapiens_hsa003100.74309803
69Endocytosis_Homo sapiens_hsa041440.73621525
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.73555419
71Amoebiasis_Homo sapiens_hsa051460.73253445
72Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72781753
73* FoxO signaling pathway_Homo sapiens_hsa040680.72132006
74Asthma_Homo sapiens_hsa053100.71886286
75Shigellosis_Homo sapiens_hsa051310.70507422
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70379648
77African trypanosomiasis_Homo sapiens_hsa051430.69598468
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.68059645
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68057489
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67251192
81Endometrial cancer_Homo sapiens_hsa052130.66985381
82Fatty acid biosynthesis_Homo sapiens_hsa000610.66746884
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66248241
84Insulin signaling pathway_Homo sapiens_hsa049100.65877212
85Chemical carcinogenesis_Homo sapiens_hsa052040.64820179
86Prion diseases_Homo sapiens_hsa050200.64726497
87Hepatitis C_Homo sapiens_hsa051600.63871446
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63264457
89mTOR signaling pathway_Homo sapiens_hsa041500.63097129
90Lysosome_Homo sapiens_hsa041420.61788281
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61671519
92Dilated cardiomyopathy_Homo sapiens_hsa054140.61642329
93HIF-1 signaling pathway_Homo sapiens_hsa040660.61351401
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.60532699
95Gastric acid secretion_Homo sapiens_hsa049710.60394087
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59433452
97Dorso-ventral axis formation_Homo sapiens_hsa043200.58929981
98Measles_Homo sapiens_hsa051620.58603498
99Phenylalanine metabolism_Homo sapiens_hsa003600.58201290
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58059791
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.57870099
102Apoptosis_Homo sapiens_hsa042100.57858883
103Long-term potentiation_Homo sapiens_hsa047200.57786391
104Estrogen signaling pathway_Homo sapiens_hsa049150.57672757
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57270718
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56539089
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56070808
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56055677
109Acute myeloid leukemia_Homo sapiens_hsa052210.55526138
1102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55273006
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55014947
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54838048
113NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54505029
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52740995
115ErbB signaling pathway_Homo sapiens_hsa040120.50049529
116Inositol phosphate metabolism_Homo sapiens_hsa005620.49898024
117Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49050256
118Rap1 signaling pathway_Homo sapiens_hsa040150.48159476
119Glioma_Homo sapiens_hsa052140.47879408
120Platelet activation_Homo sapiens_hsa046110.47678226
121Histidine metabolism_Homo sapiens_hsa003400.47166015
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46534417
123Glycerolipid metabolism_Homo sapiens_hsa005610.45762591
124Salmonella infection_Homo sapiens_hsa051320.45475861
125Retinol metabolism_Homo sapiens_hsa008300.45095538
126Viral carcinogenesis_Homo sapiens_hsa052030.44028050
127Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43925526
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43093369
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.42319635
130VEGF signaling pathway_Homo sapiens_hsa043700.41859112
131Oxytocin signaling pathway_Homo sapiens_hsa049210.41647775
132RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41045185
133Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40980900
134Prostate cancer_Homo sapiens_hsa052150.39613263
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.38452768
136Salivary secretion_Homo sapiens_hsa049700.38150209
137Mineral absorption_Homo sapiens_hsa049780.37784349
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36747541
139Jak-STAT signaling pathway_Homo sapiens_hsa046300.36423321
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36247586
141Focal adhesion_Homo sapiens_hsa045100.35538694
142Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34627032
143Glucagon signaling pathway_Homo sapiens_hsa049220.34471882
144Hematopoietic cell lineage_Homo sapiens_hsa046400.34133490
145Legionellosis_Homo sapiens_hsa051340.33898946
146MAPK signaling pathway_Homo sapiens_hsa040100.33100018

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