

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | lymph vessel development (GO:0001945) | 7.91900231 |
| 2 | vascular endothelial growth factor signaling pathway (GO:0038084) | 6.90322874 |
| 3 | endothelium development (GO:0003158) | 6.72175189 |
| 4 | positive regulation of vasculogenesis (GO:2001214) | 5.92124701 |
| 5 | retina vasculature morphogenesis in camera-type eye (GO:0061299) | 5.83757870 |
| 6 | cellular response to vascular endothelial growth factor stimulus (GO:0035924) | 5.70053879 |
| 7 | heart trabecula formation (GO:0060347) | 5.33273017 |
| 8 | cardiac myofibril assembly (GO:0055003) | 5.31632922 |
| 9 | wound healing, spreading of epidermal cells (GO:0035313) | 5.27481198 |
| 10 | blood vessel maturation (GO:0001955) | 5.26578275 |
| 11 | endothelial tube morphogenesis (GO:0061154) | 5.23317108 |
| 12 | morphogenesis of an endothelium (GO:0003159) | 5.23317108 |
| 13 | protein kinase C signaling (GO:0070528) | 5.12584020 |
| 14 | sarcomere organization (GO:0045214) | 5.06607593 |
| 15 | regulation of vasculogenesis (GO:2001212) | 4.90939396 |
| 16 | lymphangiogenesis (GO:0001946) | 4.90189404 |
| 17 | vascular endothelial growth factor receptor signaling pathway (GO:0048010) | 4.86229697 |
| 18 | regulation of endothelial cell differentiation (GO:0045601) | 4.75147591 |
| 19 | plasma membrane repair (GO:0001778) | 4.73257905 |
| 20 | labyrinthine layer development (GO:0060711) | 4.70512755 |
| 21 | endothelial cell morphogenesis (GO:0001886) | 4.64801506 |
| 22 | endothelial cell proliferation (GO:0001935) | 4.63845710 |
| 23 | cell migration involved in sprouting angiogenesis (GO:0002042) | 4.63349919 |
| 24 | patterning of blood vessels (GO:0001569) | 4.58381704 |
| 25 | basement membrane organization (GO:0071711) | 4.50440633 |
| 26 | myofibril assembly (GO:0030239) | 4.43885336 |
| 27 | blood vessel endothelial cell migration (GO:0043534) | 4.20424628 |
| 28 | regulation of sarcomere organization (GO:0060297) | 4.20157903 |
| 29 | glomerular filtration (GO:0003094) | 4.16727043 |
| 30 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 4.16490211 |
| 31 | endothelial cell differentiation (GO:0045446) | 4.16401769 |
| 32 | surfactant homeostasis (GO:0043129) | 4.10702118 |
| 33 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 4.08639385 |
| 34 | hyaluronan catabolic process (GO:0030214) | 4.08467045 |
| 35 | artery development (GO:0060840) | 4.06409074 |
| 36 | vasculogenesis (GO:0001570) | 4.03285420 |
| 37 | venous blood vessel morphogenesis (GO:0048845) | 4.02755728 |
| 38 | embryonic heart tube development (GO:0035050) | 4.01358323 |
| 39 | angiogenesis (GO:0001525) | 4.00874056 |
| 40 | ventricular cardiac muscle tissue morphogenesis (GO:0055010) | 3.97108254 |
| 41 | negative regulation of angiogenesis (GO:0016525) | 3.94875804 |
| 42 | renal filtration (GO:0097205) | 3.94571919 |
| 43 | ovulation from ovarian follicle (GO:0001542) | 3.94543552 |
| 44 | mRNA transcription from RNA polymerase II promoter (GO:0042789) | 3.90115575 |
| 45 | ventricular trabecula myocardium morphogenesis (GO:0003222) | 3.88214993 |
| 46 | sprouting angiogenesis (GO:0002040) | 3.84428966 |
| 47 | negative regulation of adherens junction organization (GO:1903392) | 3.81201463 |
| 48 | negative regulation of focal adhesion assembly (GO:0051895) | 3.81201463 |
| 49 | negative regulation of cell junction assembly (GO:1901889) | 3.81201463 |
| 50 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 3.81175742 |
| 51 | negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948) | 3.78924291 |
| 52 | negative regulation of blood vessel morphogenesis (GO:2000181) | 3.78461095 |
| 53 | regulation of establishment or maintenance of cell polarity (GO:0032878) | 3.76807116 |
| 54 | positive regulation of cell junction assembly (GO:1901890) | 3.67484566 |
| 55 | positive regulation of focal adhesion assembly (GO:0051894) | 3.67484566 |
| 56 | cardiac muscle tissue morphogenesis (GO:0055008) | 3.67471423 |
| 57 | cardiac muscle cell development (GO:0055013) | 3.65160699 |
| 58 | positive regulation of urine volume (GO:0035810) | 3.64202815 |
| 59 | heart trabecula morphogenesis (GO:0061384) | 3.63103249 |
| 60 | regulation of actin filament-based movement (GO:1903115) | 3.59448722 |
| 61 | regulation of cardioblast differentiation (GO:0051890) | 3.58611033 |
| 62 | negative regulation of vasculature development (GO:1901343) | 3.57601255 |
| 63 | heart valve formation (GO:0003188) | 3.57028857 |
| 64 | positive regulation of odontogenesis (GO:0042482) | 3.56264049 |
| 65 | positive regulation of adherens junction organization (GO:1903393) | 3.55769373 |
| 66 | cardiac cell development (GO:0055006) | 3.54235216 |
| 67 | actin-myosin filament sliding (GO:0033275) | 3.52187683 |
| 68 | muscle filament sliding (GO:0030049) | 3.52187683 |
| 69 | fatty acid transmembrane transport (GO:1902001) | 3.50236231 |
| 70 | regulation of cell migration involved in sprouting angiogenesis (GO:0090049) | 3.49041589 |
| 71 | actomyosin structure organization (GO:0031032) | 3.46058407 |
| 72 | endothelial cell migration (GO:0043542) | 3.45566771 |
| 73 | trabecula morphogenesis (GO:0061383) | 3.44289989 |
| 74 | coronary vasculature morphogenesis (GO:0060977) | 3.40945143 |
| 75 | transcytosis (GO:0045056) | 3.40825028 |
| 76 | nephron epithelium development (GO:0072009) | 3.39165656 |
| 77 | negative regulation of blood vessel endothelial cell migration (GO:0043537) | 3.38501180 |
| 78 | trabecula formation (GO:0060343) | 3.38449415 |
| 79 | Notch receptor processing (GO:0007220) | 3.37277649 |
| 80 | cAMP biosynthetic process (GO:0006171) | 3.35781504 |
| 81 | cell surface receptor signaling pathway involved in heart development (GO:0061311) | 3.35569161 |
| 82 | neuron remodeling (GO:0016322) | 3.35310769 |
| 83 | negative regulation of Rho protein signal transduction (GO:0035024) | 3.34288313 |
| 84 | cardiac muscle contraction (GO:0060048) | 3.30938204 |
| 85 | muscle tissue morphogenesis (GO:0060415) | 3.29981560 |
| 86 | plasma membrane fusion (GO:0045026) | 3.29653332 |
| 87 | regulation of the force of heart contraction (GO:0002026) | 3.27458176 |
| 88 | peptidyl-tyrosine autophosphorylation (GO:0038083) | 3.25386664 |
| 89 | positive regulation of protein kinase C signaling (GO:0090037) | 3.24928643 |
| 90 | positive regulation of endothelial cell migration (GO:0010595) | 3.23894088 |
| 91 | carnitine shuttle (GO:0006853) | 3.23525901 |
| 92 | blood vessel remodeling (GO:0001974) | 3.22693629 |
| 93 | negative regulation of endothelial cell migration (GO:0010596) | 3.22285637 |
| 94 | regulation of vascular permeability (GO:0043114) | 3.20112618 |
| 95 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 3.20100945 |
| 96 | wound healing, spreading of cells (GO:0044319) | 3.19414865 |
| 97 | positive regulation of endothelial cell proliferation (GO:0001938) | 3.18162779 |
| 98 | Notch signaling involved in heart development (GO:0061314) | 3.17052052 |
| 99 | chemical homeostasis within a tissue (GO:0048875) | 3.16737109 |
| 100 | regulation of cell-substrate junction assembly (GO:0090109) | 3.15806317 |
| 101 | regulation of focal adhesion assembly (GO:0051893) | 3.15806317 |
| 102 | SMAD protein complex assembly (GO:0007183) | 3.14467546 |
| 103 | adult heart development (GO:0007512) | 3.12874164 |
| 104 | tricarboxylic acid cycle (GO:0006099) | 3.12362537 |
| 105 | regulation of adherens junction organization (GO:1903391) | 3.11187116 |
| 106 | regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947) | 3.10847666 |
| 107 | semaphorin-plexin signaling pathway (GO:0071526) | 3.10563172 |
| 108 | regulation of endothelial cell apoptotic process (GO:2000351) | 3.10007767 |
| 109 | ventricular cardiac muscle cell action potential (GO:0086005) | 3.08599082 |
| 110 | cardiac muscle cell proliferation (GO:0060038) | 3.06508647 |
| 111 | regulation of epithelial cell migration (GO:0010632) | 3.05846275 |
| 112 | mRNA transcription (GO:0009299) | 3.04636113 |
| 113 | negative regulation of potassium ion transport (GO:0043267) | 3.03028485 |
| 114 | ganglion development (GO:0061548) | 3.02593968 |
| 115 | anatomical structure maturation (GO:0071695) | 3.00434541 |
| 116 | substrate-dependent cell migration (GO:0006929) | 2.97500660 |
| 117 | regulation of p38MAPK cascade (GO:1900744) | 2.96857752 |
| 118 | positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949) | 2.96688942 |
| 119 | actin-mediated cell contraction (GO:0070252) | 2.95731741 |
| 120 | negative regulation of DNA biosynthetic process (GO:2000279) | 2.95637527 |
| 121 | neuron projection extension involved in neuron projection guidance (GO:1902284) | 2.94520520 |
| 122 | axon extension involved in axon guidance (GO:0048846) | 2.94520520 |
| 123 | cardiac muscle hypertrophy (GO:0003300) | 2.93047201 |
| 124 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 2.91509102 |
| 125 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 2.88307591 |
| 126 | negative regulation of nitric-oxide synthase activity (GO:0051001) | 2.87201103 |
| 127 | aorta morphogenesis (GO:0035909) | 2.87167073 |
| 128 | regulation of angiogenesis (GO:0045765) | 2.85376215 |
| 129 | negative regulation of vascular permeability (GO:0043116) | 2.85188263 |
| 130 | angiogenesis involved in wound healing (GO:0060055) | 2.85010741 |
| 131 | endothelial cell chemotaxis (GO:0035767) | 2.83764994 |
| 132 | regulation of endothelial cell proliferation (GO:0001936) | 2.78658822 |
| 133 | negative regulation of platelet activation (GO:0010544) | 2.78359836 |
| 134 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 2.77304223 |
| 135 | striated muscle hypertrophy (GO:0014897) | 2.76942399 |
| 136 | adherens junction assembly (GO:0034333) | 2.75311701 |
| 137 | regulation of cardiac muscle cell contraction (GO:0086004) | 2.74975858 |
| 138 | positive regulation of endothelial cell differentiation (GO:0045603) | 2.74619445 |
| 139 | establishment of endothelial barrier (GO:0061028) | 2.74111964 |
| 140 | regulation of endothelial cell migration (GO:0010594) | 2.74056324 |
| 141 | heart morphogenesis (GO:0003007) | 2.72532889 |
| 142 | gap junction assembly (GO:0016264) | 2.71690932 |
| 143 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 2.70609505 |
| 144 | blood vessel morphogenesis (GO:0048514) | 2.67838818 |
| 145 | regulation of relaxation of muscle (GO:1901077) | 2.67818791 |
| 146 | regulation of blood vessel endothelial cell migration (GO:0043535) | 2.66357289 |
| 147 | exocrine pancreas development (GO:0031017) | 2.64756899 |
| 148 | negative regulation of endothelial cell apoptotic process (GO:2000352) | 2.63606200 |
| 149 | negative regulation of epithelial cell migration (GO:0010633) | 2.62535421 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 5.50154904 |
| 2 | CLOCK_20551151_ChIP-Seq_293T_Human | 3.66328922 |
| 3 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 3.56178035 |
| 4 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 3.44083268 |
| 5 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 3.32841147 |
| 6 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 3.23325472 |
| 7 | ZNF263_19887448_ChIP-Seq_K562_Human | 3.09553668 |
| 8 | GATA1_22025678_ChIP-Seq_K562_Human | 3.00030110 |
| 9 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 2.91119321 |
| 10 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 2.89681078 |
| 11 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 2.89681078 |
| 12 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 2.79541408 |
| 13 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 2.58942359 |
| 14 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.57524777 |
| 15 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 2.55540901 |
| 16 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 2.49950783 |
| 17 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 2.49303788 |
| 18 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 2.20927144 |
| 19 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 2.19938190 |
| 20 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.07806879 |
| 21 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.99365537 |
| 22 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.99016835 |
| 23 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.96539210 |
| 24 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.95304612 |
| 25 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.93651784 |
| 26 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.93311934 |
| 27 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 1.88989261 |
| 28 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 1.86631852 |
| 29 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.80217712 |
| 30 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.80096960 |
| 31 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.80096960 |
| 32 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.80096960 |
| 33 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.78680529 |
| 34 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 1.73353694 |
| 35 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.70985544 |
| 36 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 1.68280923 |
| 37 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.61029713 |
| 38 | GATA1_19941826_ChIP-Seq_K562_Human | 1.57727083 |
| 39 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.56903718 |
| 40 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.56161784 |
| 41 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 1.55151581 |
| 42 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.54531419 |
| 43 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 1.54011044 |
| 44 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.53166820 |
| 45 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.50835817 |
| 46 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.48609633 |
| 47 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.47171338 |
| 48 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 1.46707089 |
| 49 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 1.46707089 |
| 50 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.46448355 |
| 51 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.45977922 |
| 52 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 1.42057600 |
| 53 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 1.40194948 |
| 54 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 1.38972176 |
| 55 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.36188276 |
| 56 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 1.36059914 |
| 57 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.34293165 |
| 58 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.34039667 |
| 59 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 1.31173055 |
| 60 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.30383937 |
| 61 | CJUN_26792858_Chip-Seq_BT549_Human | 1.30359475 |
| 62 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 1.27912547 |
| 63 | BRD4_25478319_ChIP-Seq_HGPS_Human | 1.27742207 |
| 64 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.27302364 |
| 65 | KDM2B_26808549_Chip-Seq_K562_Human | 1.27130993 |
| 66 | * SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 1.26340986 |
| 67 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.26122243 |
| 68 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.25104044 |
| 69 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.24638638 |
| 70 | FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human | 1.23782000 |
| 71 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 1.21134295 |
| 72 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 1.20353451 |
| 73 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 1.18897493 |
| 74 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 1.18269615 |
| 75 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.17410472 |
| 76 | GATA4_21415370_ChIP-Seq_HL-1_Mouse | 1.17082881 |
| 77 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 1.16731884 |
| 78 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.16680829 |
| 79 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.15793373 |
| 80 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.15121631 |
| 81 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 1.15058003 |
| 82 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 1.15058003 |
| 83 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.14472945 |
| 84 | ATF3_27146783_Chip-Seq_COLON_Human | 1.12257347 |
| 85 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.11822026 |
| 86 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 1.11428677 |
| 87 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.10712808 |
| 88 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.10653386 |
| 89 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.10199357 |
| 90 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 1.08630856 |
| 91 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 1.07568566 |
| 92 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.06379180 |
| 93 | * ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.05801354 |
| 94 | * EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.05443480 |
| 95 | * SMC3_22415368_ChIP-Seq_MEFs_Mouse | 1.05002372 |
| 96 | UBF1/2_26484160_Chip-Seq_HMECs_Human | 1.04713120 |
| 97 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.04471108 |
| 98 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 1.03271108 |
| 99 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.02582186 |
| 100 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.02374507 |
| 101 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.01980746 |
| 102 | * SMC1_22415368_ChIP-Seq_MEFs_Mouse | 1.00760284 |
| 103 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 0.99665533 |
| 104 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 0.97291802 |
| 105 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.95499488 |
| 106 | PRDM14_21183938_ChIP-Seq_MESCs_Mouse | 0.94984210 |
| 107 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.94271156 |
| 108 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.94005433 |
| 109 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 0.93850528 |
| 110 | PPARG_20176806_ChIP-Seq_3T3-L1_Mouse | 0.93143277 |
| 111 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 0.92080312 |
| 112 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.90667798 |
| 113 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 0.90620601 |
| 114 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 0.90593771 |
| 115 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.90513512 |
| 116 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 0.90071661 |
| 117 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 0.88521296 |
| 118 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 0.88175214 |
| 119 | EOMES_20176728_ChIP-ChIP_TSCs_Mouse | 0.88003124 |
| 120 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.87825126 |
| 121 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.87163942 |
| 122 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 0.87120405 |
| 123 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.87026717 |
| 124 | TP53_23651856_ChIP-Seq_MEFs_Mouse | 0.86793202 |
| 125 | SOX11_22085726_ChIP-Seq_ESNs_Mouse | 0.86695193 |
| 126 | SOX2_20726797_ChIP-Seq_SW620_Human | 0.85029919 |
| 127 | SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 0.84563005 |
| 128 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 0.84065836 |
| 129 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 0.83371247 |
| 130 | * SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 0.81632537 |
| 131 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 0.80166434 |
| 132 | * UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 0.79753400 |
| 133 | * SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 0.77873373 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0010368_abnormal_lymphatic_system | 6.41796218 |
| 2 | MP0001879_abnormal_lymphatic_vessel | 4.81740996 |
| 3 | MP0004084_abnormal_cardiac_muscle | 4.46047530 |
| 4 | MP0004272_abnormal_basement_membrane | 4.29397186 |
| 5 | MP0005167_abnormal_blood-brain_barrier | 3.80448697 |
| 6 | MP0002837_dystrophic_cardiac_calcinosis | 3.57089545 |
| 7 | MP0004215_abnormal_myocardial_fiber | 3.48117889 |
| 8 | MP0004036_abnormal_muscle_relaxation | 2.91272877 |
| 9 | MP0003828_pulmonary_edema | 2.90495644 |
| 10 | MP0000751_myopathy | 2.75255404 |
| 11 | MP0000465_gastrointestinal_hemorrhage | 2.64675878 |
| 12 | MP0003303_peritoneal_inflammation | 2.56630633 |
| 13 | MP0005330_cardiomyopathy | 2.51463160 |
| 14 | MP0006138_congestive_heart_failure | 2.51435868 |
| 15 | MP0003705_abnormal_hypodermis_morpholog | 2.31244320 |
| 16 | MP0008775_abnormal_heart_ventricle | 2.21802804 |
| 17 | MP0010630_abnormal_cardiac_muscle | 2.15819853 |
| 18 | MP0002972_abnormal_cardiac_muscle | 2.13284709 |
| 19 | MP0005409_darkened_coat_color | 2.10065040 |
| 20 | MP0004782_abnormal_surfactant_physiolog | 2.06920177 |
| 21 | MP0005385_cardiovascular_system_phenoty | 2.06269222 |
| 22 | MP0001544_abnormal_cardiovascular_syste | 2.06269222 |
| 23 | MP0003279_aneurysm | 2.03996626 |
| 24 | MP0002127_abnormal_cardiovascular_syste | 1.97657297 |
| 25 | MP0004087_abnormal_muscle_fiber | 1.88340666 |
| 26 | MP0003646_muscle_fatigue | 1.86763597 |
| 27 | MP0000750_abnormal_muscle_regeneration | 1.83853831 |
| 28 | MP0000749_muscle_degeneration | 1.81585596 |
| 29 | MP0006054_spinal_hemorrhage | 1.79497047 |
| 30 | MP0005620_abnormal_muscle_contractility | 1.76855330 |
| 31 | MP0000767_abnormal_smooth_muscle | 1.76717411 |
| 32 | MP0000013_abnormal_adipose_tissue | 1.76572037 |
| 33 | MP0004085_abnormal_heartbeat | 1.71607632 |
| 34 | MP0004484_altered_response_of | 1.71292369 |
| 35 | MP0005623_abnormal_meninges_morphology | 1.69256617 |
| 36 | MP0002332_abnormal_exercise_endurance | 1.65226289 |
| 37 | MP0005670_abnormal_white_adipose | 1.59336876 |
| 38 | MP0004130_abnormal_muscle_cell | 1.50989510 |
| 39 | MP0004145_abnormal_muscle_electrophysio | 1.50919412 |
| 40 | MP0003566_abnormal_cell_adhesion | 1.43082661 |
| 41 | MP0002128_abnormal_blood_circulation | 1.39765329 |
| 42 | MP0002925_abnormal_cardiovascular_devel | 1.38290782 |
| 43 | MP0003950_abnormal_plasma_membrane | 1.36292873 |
| 44 | MP0000266_abnormal_heart_morphology | 1.33740505 |
| 45 | MP0002933_joint_inflammation | 1.32948414 |
| 46 | MP0002106_abnormal_muscle_physiology | 1.32050392 |
| 47 | MP0004147_increased_porphyrin_level | 1.31948353 |
| 48 | MP0005165_increased_susceptibility_to | 1.31200511 |
| 49 | MP0010030_abnormal_orbit_morphology | 1.28072964 |
| 50 | MP0003122_maternal_imprinting | 1.27051849 |
| 51 | MP0000003_abnormal_adipose_tissue | 1.23259717 |
| 52 | MP0003137_abnormal_impulse_conducting | 1.22775845 |
| 53 | MP0003567_abnormal_fetal_cardiomyocyte | 1.16885953 |
| 54 | MP0005171_absent_coat_pigmentation | 1.14950697 |
| 55 | MP0000343_altered_response_to | 1.13196701 |
| 56 | MP0001614_abnormal_blood_vessel | 1.11540507 |
| 57 | MP0005666_abnormal_adipose_tissue | 1.10950736 |
| 58 | MP0005369_muscle_phenotype | 1.08835378 |
| 59 | MP0009278_abnormal_bone_marrow | 1.07021898 |
| 60 | MP0005375_adipose_tissue_phenotype | 1.06161184 |
| 61 | MP0000759_abnormal_skeletal_muscle | 1.06110689 |
| 62 | MP0005187_abnormal_penis_morphology | 1.05317600 |
| 63 | MP0002877_abnormal_melanocyte_morpholog | 1.03411235 |
| 64 | MP0002269_muscular_atrophy | 1.02062304 |
| 65 | MP0003984_embryonic_growth_retardation | 1.01522618 |
| 66 | MP0000249_abnormal_blood_vessel | 1.00620083 |
| 67 | MP0002088_abnormal_embryonic_growth/wei | 1.00036215 |
| 68 | MP0008438_abnormal_cutaneous_collagen | 1.00031833 |
| 69 | MP0009780_abnormal_chondrocyte_physiolo | 0.98861562 |
| 70 | MP0005595_abnormal_vascular_smooth | 0.98442865 |
| 71 | MP0003724_increased_susceptibility_to | 0.98335345 |
| 72 | MP0001849_ear_inflammation | 0.98170786 |
| 73 | MP0001784_abnormal_fluid_regulation | 0.94969550 |
| 74 | MP0001915_intracranial_hemorrhage | 0.92797209 |
| 75 | MP0002295_abnormal_pulmonary_circulatio | 0.91373133 |
| 76 | MP0003300_gastrointestinal_ulcer | 0.90807969 |
| 77 | MP0000537_abnormal_urethra_morphology | 0.89818058 |
| 78 | MP0004185_abnormal_adipocyte_glucose | 0.88552435 |
| 79 | MP0002086_abnormal_extraembryonic_tissu | 0.88463276 |
| 80 | MP0009697_abnormal_copulation | 0.86947292 |
| 81 | MP0005084_abnormal_gallbladder_morpholo | 0.85352049 |
| 82 | MP0003221_abnormal_cardiomyocyte_apopto | 0.80626371 |
| 83 | MP0000733_abnormal_muscle_development | 0.78856489 |
| 84 | MP0000230_abnormal_systemic_arterial | 0.78229863 |
| 85 | MP0001672_abnormal_embryogenesis/_devel | 0.78146269 |
| 86 | MP0005380_embryogenesis_phenotype | 0.78146269 |
| 87 | MP0003091_abnormal_cell_migration | 0.77607900 |
| 88 | MP0002108_abnormal_muscle_morphology | 0.77365293 |
| 89 | MP0000516_abnormal_urinary_system | 0.76763782 |
| 90 | MP0005367_renal/urinary_system_phenotyp | 0.76763782 |
| 91 | MP0008961_abnormal_basal_metabolism | 0.75528726 |
| 92 | MP0004510_myositis | 0.73626141 |
| 93 | MP0003941_abnormal_skin_development | 0.73392063 |
| 94 | MP0002796_impaired_skin_barrier | 0.71818155 |
| 95 | MP0000747_muscle_weakness | 0.69501376 |
| 96 | MP0003045_fibrosis | 0.69135606 |
| 97 | MP0003119_abnormal_digestive_system | 0.67624717 |
| 98 | MP0005388_respiratory_system_phenotype | 0.67222530 |
| 99 | MP0002133_abnormal_respiratory_system | 0.67222530 |
| 100 | MP0001958_emphysema | 0.66242778 |
| 101 | MP0003943_abnormal_hepatobiliary_system | 0.65437575 |
| 102 | MP0010234_abnormal_vibrissa_follicle | 0.65398029 |
| 103 | MP0003948_abnormal_gas_homeostasis | 0.64663500 |
| 104 | MP0004233_abnormal_muscle_weight | 0.61768125 |
| 105 | MP0002896_abnormal_bone_mineralization | 0.61411423 |
| 106 | MP0010352_gastrointestinal_tract_polyps | 0.61400586 |
| 107 | MP0003935_abnormal_craniofacial_develop | 0.60170237 |
| 108 | MP0003385_abnormal_body_wall | 0.59866245 |
| 109 | MP0005275_abnormal_skin_tensile | 0.58527057 |
| 110 | MP0003868_abnormal_feces_composition | 0.56756900 |
| 111 | MP0009379_abnormal_foot_pigmentation | 0.54559840 |
| 112 | MP0002138_abnormal_hepatobiliary_system | 0.51097951 |
| 113 | MP0001727_abnormal_embryo_implantation | 0.51078252 |
| 114 | MP0009053_abnormal_anal_canal | 0.50130457 |
| 115 | MP0002697_abnormal_eye_size | 0.47981997 |
| 116 | MP0001730_embryonic_growth_arrest | 0.44693794 |
| 117 | MP0005501_abnormal_skin_physiology | 0.44528794 |
| 118 | MP0001175_abnormal_lung_morphology | 0.44288869 |
| 119 | MP0002932_abnormal_joint_morphology | 0.44278834 |
| 120 | MP0008004_abnormal_stomach_pH | 0.43788046 |
| 121 | MP0005451_abnormal_body_composition | 0.43145269 |
| 122 | MP0005023_abnormal_wound_healing | 0.42741571 |
| 123 | MP0001191_abnormal_skin_condition | 0.41992059 |
| 124 | MP0000467_abnormal_esophagus_morphology | 0.39296732 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Sudden death (HP:0001699) | 5.87998286 |
| 2 | Ventricular tachycardia (HP:0004756) | 5.47409153 |
| 3 | Tetraparesis (HP:0002273) | 5.31838489 |
| 4 | Muscle fiber splitting (HP:0003555) | 5.15005231 |
| 5 | Atrial fibrillation (HP:0005110) | 4.71717690 |
| 6 | Hyporeflexia of lower limbs (HP:0002600) | 4.43825973 |
| 7 | Supraventricular arrhythmia (HP:0005115) | 4.39406712 |
| 8 | Primary atrial arrhythmia (HP:0001692) | 4.35866429 |
| 9 | Increased connective tissue (HP:0009025) | 4.30051477 |
| 10 | Supraventricular tachycardia (HP:0004755) | 4.15561682 |
| 11 | Polycythemia (HP:0001901) | 4.14965265 |
| 12 | Exercise-induced muscle cramps (HP:0003710) | 4.13591640 |
| 13 | Hypoglycemic coma (HP:0001325) | 4.05209785 |
| 14 | Arterial tortuosity (HP:0005116) | 4.05095599 |
| 15 | Lipoatrophy (HP:0100578) | 3.99456017 |
| 16 | Hemiplegia (HP:0002301) | 3.92965152 |
| 17 | Lymphangioma (HP:0100764) | 3.87396839 |
| 18 | Right ventricular cardiomyopathy (HP:0011663) | 3.85058010 |
| 19 | Vascular tortuosity (HP:0004948) | 3.71478866 |
| 20 | Difficulty running (HP:0009046) | 3.65111073 |
| 21 | Abnormality of the left ventricular outflow tract (HP:0011103) | 3.53368156 |
| 22 | Subaortic stenosis (HP:0001682) | 3.53368156 |
| 23 | Prolonged QT interval (HP:0001657) | 3.46808764 |
| 24 | Hyperinsulinemic hypoglycemia (HP:0000825) | 3.45566869 |
| 25 | Cerebral aneurysm (HP:0004944) | 3.43750694 |
| 26 | Calf muscle hypertrophy (HP:0008981) | 3.41389872 |
| 27 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 3.36235627 |
| 28 | Dilated cardiomyopathy (HP:0001644) | 3.35107371 |
| 29 | Myoglobinuria (HP:0002913) | 3.34297310 |
| 30 | Hematochezia (HP:0002573) | 3.33123716 |
| 31 | Myotonia (HP:0002486) | 3.29837319 |
| 32 | Syncope (HP:0001279) | 3.26828224 |
| 33 | Esophageal varix (HP:0002040) | 3.24662284 |
| 34 | Exercise-induced myalgia (HP:0003738) | 3.23148884 |
| 35 | Abnormality of the calf musculature (HP:0001430) | 3.13013454 |
| 36 | Asymmetric septal hypertrophy (HP:0001670) | 3.07925684 |
| 37 | Skull defect (HP:0001362) | 3.05590016 |
| 38 | EMG: myopathic abnormalities (HP:0003458) | 3.05208693 |
| 39 | Muscle hypertrophy of the lower extremities (HP:0008968) | 3.05078989 |
| 40 | Atrioventricular block (HP:0001678) | 3.03445476 |
| 41 | Spontaneous hematomas (HP:0007420) | 3.01590895 |
| 42 | Pancreatic islet-cell hyperplasia (HP:0004510) | 2.98497570 |
| 43 | Palpitations (HP:0001962) | 2.98061699 |
| 44 | Difficulty climbing stairs (HP:0003551) | 2.90966294 |
| 45 | Stroke (HP:0001297) | 2.88354143 |
| 46 | Bundle branch block (HP:0011710) | 2.87614246 |
| 47 | Protrusio acetabuli (HP:0003179) | 2.87214473 |
| 48 | Neonatal death (HP:0003811) | 2.85469240 |
| 49 | Broad metatarsal (HP:0001783) | 2.80655851 |
| 50 | Exotropia (HP:0000577) | 2.77065516 |
| 51 | Heart block (HP:0012722) | 2.76469040 |
| 52 | Hypoglycemic seizures (HP:0002173) | 2.75451504 |
| 53 | Aortic aneurysm (HP:0004942) | 2.74598684 |
| 54 | Premature rupture of membranes (HP:0001788) | 2.74524776 |
| 55 | Nonimmune hydrops fetalis (HP:0001790) | 2.68726783 |
| 56 | Ventricular fibrillation (HP:0001663) | 2.66046850 |
| 57 | Scotoma (HP:0000575) | 2.63598080 |
| 58 | Abnormal atrioventricular conduction (HP:0005150) | 2.62644635 |
| 59 | Ventricular arrhythmia (HP:0004308) | 2.62363855 |
| 60 | Rhabdomyolysis (HP:0003201) | 2.60353107 |
| 61 | Aneurysm (HP:0002617) | 2.57468008 |
| 62 | Increased variability in muscle fiber diameter (HP:0003557) | 2.54175327 |
| 63 | Spinal rigidity (HP:0003306) | 2.53606435 |
| 64 | Abnormality of skeletal muscle fiber size (HP:0012084) | 2.52538360 |
| 65 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 2.50160985 |
| 66 | Distal lower limb muscle weakness (HP:0009053) | 2.49215229 |
| 67 | Cavernous hemangioma (HP:0001048) | 2.41309030 |
| 68 | Cerebral hemorrhage (HP:0001342) | 2.39680923 |
| 69 | Visceral angiomatosis (HP:0100761) | 2.39572192 |
| 70 | Ketoacidosis (HP:0001993) | 2.39227319 |
| 71 | Adactyly (HP:0009776) | 2.38143299 |
| 72 | Nemaline bodies (HP:0003798) | 2.33903928 |
| 73 | Lymphedema (HP:0001004) | 2.32279140 |
| 74 | Pulmonary hypertension (HP:0002092) | 2.31853814 |
| 75 | Hypoplastic ischia (HP:0003175) | 2.31385930 |
| 76 | Large for gestational age (HP:0001520) | 2.27294239 |
| 77 | Hemangiomatosis (HP:0007461) | 2.26498805 |
| 78 | Myocardial infarction (HP:0001658) | 2.23459276 |
| 79 | Venous insufficiency (HP:0005293) | 2.23357824 |
| 80 | Muscle stiffness (HP:0003552) | 2.22977668 |
| 81 | Abnormality of endocrine pancreas physiology (HP:0012093) | 2.22701954 |
| 82 | Abnormality of the pancreatic islet cells (HP:0006476) | 2.22701954 |
| 83 | Shallow orbits (HP:0000586) | 2.22000656 |
| 84 | Hydroureter (HP:0000072) | 2.18995704 |
| 85 | Areflexia of lower limbs (HP:0002522) | 2.17075337 |
| 86 | Abnormal EKG (HP:0003115) | 2.16496508 |
| 87 | Limb-girdle muscle atrophy (HP:0003797) | 2.16352140 |
| 88 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 2.15188125 |
| 89 | Limb dystonia (HP:0002451) | 2.13972154 |
| 90 | Aortic dissection (HP:0002647) | 2.13118655 |
| 91 | Absent hand (HP:0004050) | 2.12780243 |
| 92 | Muscle fiber inclusion bodies (HP:0100299) | 2.12748377 |
| 93 | Porencephaly (HP:0002132) | 2.11243014 |
| 94 | Abnormality of the ischium (HP:0003174) | 2.10914231 |
| 95 | Vertebral clefting (HP:0008428) | 2.10022592 |
| 96 | Abnormal vertebral ossification (HP:0100569) | 2.09929376 |
| 97 | Hyperglycemia (HP:0003074) | 2.09506932 |
| 98 | Round ear (HP:0100830) | 2.08993483 |
| 99 | Overgrowth (HP:0001548) | 2.08138143 |
| 100 | Rectal prolapse (HP:0002035) | 2.07423847 |
| 101 | Distal lower limb amyotrophy (HP:0008944) | 2.07241028 |
| 102 | Facial diplegia (HP:0001349) | 2.07148508 |
| 103 | Polygenic inheritance (HP:0010982) | 2.07096894 |
| 104 | Distal arthrogryposis (HP:0005684) | 2.06750481 |
| 105 | Wrist flexion contracture (HP:0001239) | 2.02703447 |
| 106 | Abnormal platelet function (HP:0011869) | 2.00402649 |
| 107 | Impaired platelet aggregation (HP:0003540) | 2.00402649 |
| 108 | Short 4th metacarpal (HP:0010044) | 1.99712729 |
| 109 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 1.99712729 |
| 110 | Mitral valve prolapse (HP:0001634) | 1.99086668 |
| 111 | Hip contracture (HP:0003273) | 1.98825401 |
| 112 | Limited hip movement (HP:0008800) | 1.96949214 |
| 113 | Abnormality of the 4th metacarpal (HP:0010012) | 1.95983633 |
| 114 | Congenital cataract (HP:0000519) | 1.95657593 |
| 115 | Absent eyelashes (HP:0000561) | 1.95225277 |
| 116 | Venous abnormality (HP:0002624) | 1.95106929 |
| 117 | Hypoplasia of the iris (HP:0007676) | 1.94890123 |
| 118 | Menorrhagia (HP:0000132) | 1.94333583 |
| 119 | Trismus (HP:0000211) | 1.93835144 |
| 120 | Aortic valve stenosis (HP:0001650) | 1.92802250 |
| 121 | Pulmonary artery stenosis (HP:0004415) | 1.92714973 |
| 122 | High pitched voice (HP:0001620) | 1.92320189 |
| 123 | Portal hypertension (HP:0001409) | 1.91968139 |
| 124 | Conjunctival telangiectasia (HP:0000524) | 1.91551246 |
| 125 | Ectopia lentis (HP:0001083) | 1.91049510 |
| 126 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 1.89795636 |
| 127 | Disproportionate tall stature (HP:0001519) | 1.86289945 |
| 128 | Hemorrhage of the eye (HP:0011885) | 1.82651012 |
| 129 | Cutis marmorata (HP:0000965) | 1.81042357 |
| 130 | Nuclear cataract (HP:0100018) | 1.80982955 |
| 131 | Absent eyebrow (HP:0002223) | 1.79062841 |
| 132 | Joint contractures involving the joints of the feet (HP:0100492) | 1.78449274 |
| 133 | Flexion contracture of toe (HP:0005830) | 1.78449274 |
| 134 | Abnormality of the nasal mucosa (HP:0000433) | 1.77226201 |
| 135 | Bulbous nose (HP:0000414) | 1.75148577 |
| 136 | Symptomatic seizures (HP:0011145) | 1.74818049 |
| 137 | Mucosal telangiectasiae (HP:0100579) | 1.74718840 |
| 138 | Blue sclerae (HP:0000592) | 1.72229590 |
| 139 | Intestinal polyposis (HP:0200008) | 1.72168262 |
| 140 | Congestive heart failure (HP:0001635) | 1.71436824 |
| 141 | Malignant hyperthermia (HP:0002047) | 1.71417967 |
| 142 | Mesangial abnormality (HP:0001966) | 1.71246112 |
| 143 | Striae distensae (HP:0001065) | 1.71061237 |
| 144 | Interstitial pulmonary disease (HP:0006530) | 1.70886072 |
| 145 | Intestinal polyp (HP:0005266) | 1.70756278 |
| 146 | Type 1 muscle fiber predominance (HP:0003803) | 1.70344638 |
| 147 | Delayed CNS myelination (HP:0002188) | 1.70113980 |
| 148 | Neoplasm of the oral cavity (HP:0100649) | 1.69794091 |
| 149 | Mildly elevated creatine phosphokinase (HP:0008180) | 1.68440743 |
| 150 | EMG: neuropathic changes (HP:0003445) | 1.67914770 |
| 151 | Abnormality of the hepatic vasculature (HP:0006707) | 1.66937130 |
| 152 | Capillary hemangiomas (HP:0005306) | 1.65667507 |
| 153 | Scapular winging (HP:0003691) | 1.62724095 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TIE1 | 9.22882545 |
| 2 | KDR | 6.71694480 |
| 3 | TTN | 2.70271209 |
| 4 | TGFBR2 | 2.67410601 |
| 5 | FES | 2.62940903 |
| 6 | TGFBR1 | 2.48089540 |
| 7 | RIPK1 | 2.33708841 |
| 8 | PTK2B | 2.19639414 |
| 9 | PKN2 | 2.19390264 |
| 10 | EPHB2 | 1.95477073 |
| 11 | DMPK | 1.77561144 |
| 12 | MYLK | 1.72988035 |
| 13 | TRIB3 | 1.71074614 |
| 14 | PDK2 | 1.61724580 |
| 15 | MAP2K3 | 1.61030539 |
| 16 | INSRR | 1.56657077 |
| 17 | PTK6 | 1.51697051 |
| 18 | ERN1 | 1.38632862 |
| 19 | PDK3 | 1.38246064 |
| 20 | PDK4 | 1.38246064 |
| 21 | PDGFRA | 1.38230007 |
| 22 | MAP3K3 | 1.33545718 |
| 23 | PHKG2 | 1.33166264 |
| 24 | PHKG1 | 1.33166264 |
| 25 | LMTK2 | 1.30538671 |
| 26 | OBSCN | 1.28838648 |
| 27 | PRKG2 | 1.17373763 |
| 28 | TEC | 1.13142147 |
| 29 | FER | 1.11764320 |
| 30 | NTRK1 | 1.11403551 |
| 31 | SCYL2 | 1.05664395 |
| 32 | LATS1 | 0.99209854 |
| 33 | BCKDK | 0.98734594 |
| 34 | PRKD1 | 0.98437833 |
| 35 | PTK2 | 0.97645941 |
| 36 | EPHB1 | 0.97604186 |
| 37 | PRKD3 | 0.92504790 |
| 38 | GRK1 | 0.91808019 |
| 39 | FGFR4 | 0.87840550 |
| 40 | MAPK12 | 0.86738590 |
| 41 | CDK12 | 0.83947009 |
| 42 | BMPR1B | 0.82630713 |
| 43 | STK24 | 0.80752026 |
| 44 | PAK4 | 0.79106868 |
| 45 | MET | 0.73840089 |
| 46 | TSSK6 | 0.70812827 |
| 47 | EPHA2 | 0.70302308 |
| 48 | FGFR3 | 0.70037952 |
| 49 | FLT3 | 0.69527873 |
| 50 | AKT3 | 0.69015478 |
| 51 | MAP3K13 | 0.68878493 |
| 52 | PRKAA2 | 0.67450680 |
| 53 | MOS | 0.67107784 |
| 54 | MAP3K10 | 0.66995900 |
| 55 | MARK3 | 0.65474674 |
| 56 | MTOR | 0.62856477 |
| 57 | ARAF | 0.62185979 |
| 58 | MAPK7 | 0.62007762 |
| 59 | EEF2K | 0.60430215 |
| 60 | CDK8 | 0.56404600 |
| 61 | LRRK2 | 0.54189138 |
| 62 | TRPM7 | 0.53857491 |
| 63 | MAP3K1 | 0.51998011 |
| 64 | CDC42BPA | 0.51885955 |
| 65 | PRKAA1 | 0.51680163 |
| 66 | LATS2 | 0.51313436 |
| 67 | WNK4 | 0.50427215 |
| 68 | PIK3CA | 0.47486011 |
| 69 | PAK3 | 0.47025511 |
| 70 | ILK | 0.46262054 |
| 71 | PDGFRB | 0.46049426 |
| 72 | MAPK15 | 0.45883794 |
| 73 | ROCK1 | 0.43420634 |
| 74 | PRKCH | 0.43229232 |
| 75 | ZAP70 | 0.41417247 |
| 76 | GSK3A | 0.40787531 |
| 77 | NEK1 | 0.40751435 |
| 78 | SIK1 | 0.40014024 |
| 79 | BCR | 0.39735487 |
| 80 | IGF1R | 0.39205010 |
| 81 | STK38L | 0.38545556 |
| 82 | ROCK2 | 0.38392939 |
| 83 | RET | 0.38074948 |
| 84 | CSK | 0.37206607 |
| 85 | CAMK4 | 0.36255479 |
| 86 | TESK1 | 0.33982261 |
| 87 | PAK2 | 0.33281022 |
| 88 | MAP2K2 | 0.33086035 |
| 89 | PRKCE | 0.33071834 |
| 90 | PASK | 0.33003773 |
| 91 | TYRO3 | 0.32856587 |
| 92 | NLK | 0.32497773 |
| 93 | RPS6KA2 | 0.30628861 |
| 94 | STK3 | 0.30262101 |
| 95 | HCK | 0.30144963 |
| 96 | ERBB4 | 0.29852051 |
| 97 | STK10 | 0.29179446 |
| 98 | PIK3CG | 0.28583298 |
| 99 | MARK2 | 0.28156644 |
| 100 | EPHA3 | 0.28053364 |
| 101 | FGFR2 | 0.27914904 |
| 102 | WNK1 | 0.27624793 |
| 103 | MAP3K11 | 0.27610647 |
| 104 | GRK5 | 0.26773808 |
| 105 | MAPKAPK3 | 0.26705137 |
| 106 | SRC | 0.25500266 |
| 107 | CDK9 | 0.24828512 |
| 108 | PRKACB | 0.24610239 |
| 109 | CAMK1D | 0.24590842 |
| 110 | EGFR | 0.22737719 |
| 111 | CAMK2D | 0.22264464 |
| 112 | JAK3 | 0.21724371 |
| 113 | MAP3K7 | 0.20940083 |
| 114 | AKT2 | 0.20871999 |
| 115 | FGFR1 | 0.20733292 |
| 116 | YES1 | 0.20559167 |
| 117 | KSR2 | 0.19855898 |
| 118 | ZAK | 0.19608078 |
| 119 | NEK9 | 0.17430656 |
| 120 | INSR | 0.16998584 |
| 121 | PINK1 | 0.15040292 |
| 122 | PDPK1 | 0.14675525 |
| 123 | ITK | 0.14578232 |
| 124 | MAP4K1 | 0.13498516 |
| 125 | IRAK3 | 0.12272266 |
| 126 | MAP3K9 | 0.10775150 |
| 127 | MAPK4 | 0.10362876 |
| 128 | BRAF | 0.09041716 |
| 129 | PRKD2 | 0.08708045 |
| 130 | KIT | 0.06609496 |
| 131 | MAP3K8 | 0.06411243 |
| 132 | DAPK3 | 0.06321949 |
| 133 | ABL2 | 0.06066253 |
| 134 | MAP3K12 | 0.05832784 |
| 135 | MAP2K1 | 0.04813525 |
| 136 | SGK494 | 0.04157933 |
| 137 | SGK223 | 0.04157933 |
| 138 | MAP3K6 | 0.03975511 |
| 139 | LCK | 0.03502660 |
| 140 | SMG1 | 0.03370991 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 4.32798217 |
| 2 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 3.43953021 |
| 3 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 3.17818798 |
| 4 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 3.06231427 |
| 5 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 2.61229505 |
| 6 | ECM-receptor interaction_Homo sapiens_hsa04512 | 2.54763545 |
| 7 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.49742973 |
| 8 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 2.47638653 |
| 9 | Adherens junction_Homo sapiens_hsa04520 | 2.42416388 |
| 10 | Focal adhesion_Homo sapiens_hsa04510 | 2.36168200 |
| 11 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.28566357 |
| 12 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 2.18877812 |
| 13 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.88264565 |
| 14 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.84480604 |
| 15 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.77724031 |
| 16 | Insulin resistance_Homo sapiens_hsa04931 | 1.75289866 |
| 17 | Arginine biosynthesis_Homo sapiens_hsa00220 | 1.72359587 |
| 18 | Viral myocarditis_Homo sapiens_hsa05416 | 1.72197796 |
| 19 | Prion diseases_Homo sapiens_hsa05020 | 1.68162899 |
| 20 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.67994837 |
| 21 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.61389163 |
| 22 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.59659696 |
| 23 | Malaria_Homo sapiens_hsa05144 | 1.56423611 |
| 24 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.52732877 |
| 25 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.49841654 |
| 26 | Tight junction_Homo sapiens_hsa04530 | 1.48418489 |
| 27 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.41255828 |
| 28 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.34320704 |
| 29 | Lysine degradation_Homo sapiens_hsa00310 | 1.34285638 |
| 30 | Carbon metabolism_Homo sapiens_hsa01200 | 1.32580997 |
| 31 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.32567813 |
| 32 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.29314247 |
| 33 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 1.28806734 |
| 34 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 1.27273965 |
| 35 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.26806159 |
| 36 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 1.26777270 |
| 37 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 1.23011111 |
| 38 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 1.16811084 |
| 39 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.16715709 |
| 40 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.15793814 |
| 41 | Amoebiasis_Homo sapiens_hsa05146 | 1.14254669 |
| 42 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 1.14016469 |
| 43 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 1.13613196 |
| 44 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 1.12678024 |
| 45 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 1.12590446 |
| 46 | Bladder cancer_Homo sapiens_hsa05219 | 1.06379720 |
| 47 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.04876346 |
| 48 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 1.01699045 |
| 49 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.00265017 |
| 50 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.97686172 |
| 51 | Pertussis_Homo sapiens_hsa05133 | 0.96441218 |
| 52 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.95454127 |
| 53 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.95082826 |
| 54 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.93602054 |
| 55 | Platelet activation_Homo sapiens_hsa04611 | 0.92978120 |
| 56 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.92328440 |
| 57 | Bile secretion_Homo sapiens_hsa04976 | 0.91834161 |
| 58 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.91042140 |
| 59 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.90226076 |
| 60 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.90000298 |
| 61 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.87723140 |
| 62 | Endocytosis_Homo sapiens_hsa04144 | 0.87012950 |
| 63 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.86652972 |
| 64 | Shigellosis_Homo sapiens_hsa05131 | 0.84139578 |
| 65 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.82727975 |
| 66 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.81836544 |
| 67 | Thyroid cancer_Homo sapiens_hsa05216 | 0.81793659 |
| 68 | Parkinsons disease_Homo sapiens_hsa05012 | 0.80708535 |
| 69 | Pathways in cancer_Homo sapiens_hsa05200 | 0.76507771 |
| 70 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.72418874 |
| 71 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.72310573 |
| 72 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.71690169 |
| 73 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.71427667 |
| 74 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.69885531 |
| 75 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.69354184 |
| 76 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.68478791 |
| 77 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.67490763 |
| 78 | Other glycan degradation_Homo sapiens_hsa00511 | 0.65879812 |
| 79 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.63565552 |
| 80 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.62632284 |
| 81 | Insulin secretion_Homo sapiens_hsa04911 | 0.62426797 |
| 82 | Colorectal cancer_Homo sapiens_hsa05210 | 0.62010920 |
| 83 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.60892879 |
| 84 | Gap junction_Homo sapiens_hsa04540 | 0.60641297 |
| 85 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.59203307 |
| 86 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.58992105 |
| 87 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.58976562 |
| 88 | Axon guidance_Homo sapiens_hsa04360 | 0.58649085 |
| 89 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.58020418 |
| 90 | Renin secretion_Homo sapiens_hsa04924 | 0.58010984 |
| 91 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.55583205 |
| 92 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.55412294 |
| 93 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.55332350 |
| 94 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.55291777 |
| 95 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.54868028 |
| 96 | Alzheimers disease_Homo sapiens_hsa05010 | 0.53929720 |
| 97 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.52886578 |
| 98 | Salmonella infection_Homo sapiens_hsa05132 | 0.51546480 |
| 99 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.51192705 |
| 100 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.51149649 |
| 101 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.50951673 |
| 102 | HTLV-I infection_Homo sapiens_hsa05166 | 0.50677660 |
| 103 | Glioma_Homo sapiens_hsa05214 | 0.50136943 |
| 104 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.49838952 |
| 105 | Huntingtons disease_Homo sapiens_hsa05016 | 0.48946907 |
| 106 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.48043859 |
| 107 | Melanogenesis_Homo sapiens_hsa04916 | 0.47153771 |
| 108 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.46147534 |
| 109 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.45999321 |
| 110 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.45746072 |
| 111 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.45635447 |
| 112 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.44484908 |
| 113 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.42448917 |
| 114 | Prostate cancer_Homo sapiens_hsa05215 | 0.42151815 |
| 115 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.41844342 |
| 116 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.40991263 |
| 117 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.37509321 |
| 118 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.37030480 |
| 119 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.36798865 |
| 120 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.36360241 |
| 121 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.34444868 |
| 122 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.32079887 |
| 123 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.30942464 |
| 124 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.29174989 |
| 125 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.29120856 |
| 126 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.29028515 |
| 127 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.26115691 |
| 128 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.26065492 |
| 129 | ABC transporters_Homo sapiens_hsa02010 | 0.25577797 |
| 130 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.24629269 |
| 131 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.24332442 |
| 132 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.23820154 |
| 133 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.23572448 |
| 134 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.22796683 |
| 135 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.20971037 |
| 136 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.20315407 |
| 137 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.19876655 |

