BCL7A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1V(D)J recombination (GO:0033151)4.77908283
2behavioral response to nicotine (GO:0035095)4.59535296
3locomotory exploration behavior (GO:0035641)4.31050608
4protein-DNA complex disassembly (GO:0032986)4.29138881
5nucleosome disassembly (GO:0006337)4.29138881
6L-serine transport (GO:0015825)4.27384639
7dendritic spine morphogenesis (GO:0060997)4.15449856
8lens fiber cell development (GO:0070307)3.96172360
9postsynaptic membrane organization (GO:0001941)3.91374150
10synaptic vesicle maturation (GO:0016188)3.88891418
11serine transport (GO:0032329)3.87055324
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.80979690
13layer formation in cerebral cortex (GO:0021819)3.75810258
14establishment of nucleus localization (GO:0040023)3.74343675
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.65086038
16neuronal stem cell maintenance (GO:0097150)3.63899267
17negative regulation of oligodendrocyte differentiation (GO:0048715)3.61320379
18regulation of short-term neuronal synaptic plasticity (GO:0048172)3.58087975
19neuron cell-cell adhesion (GO:0007158)3.49111105
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.46947271
21central nervous system projection neuron axonogenesis (GO:0021952)3.45373252
22nucleobase catabolic process (GO:0046113)3.44975691
23positive regulation of synapse maturation (GO:0090129)3.43473285
24pyrimidine nucleobase catabolic process (GO:0006208)3.40997691
25synaptic vesicle exocytosis (GO:0016079)3.38125939
26G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.37075699
27establishment of mitochondrion localization (GO:0051654)3.36766539
28B cell receptor signaling pathway (GO:0050853)3.35207754
29vocalization behavior (GO:0071625)3.30139527
30tachykinin receptor signaling pathway (GO:0007217)3.29995356
31protein localization to synapse (GO:0035418)3.26629314
32negative regulation of axon extension (GO:0030517)3.20486257
33axonal fasciculation (GO:0007413)3.20195005
34regulation of glutamate receptor signaling pathway (GO:1900449)3.14950698
35positive regulation by host of viral transcription (GO:0043923)3.14421948
36negative regulation of axon guidance (GO:1902668)3.13606152
37glutamate secretion (GO:0014047)3.13507378
38exploration behavior (GO:0035640)3.13212949
39cell migration in hindbrain (GO:0021535)3.11800347
40regulation of NFAT protein import into nucleus (GO:0051532)3.06991461
41axon ensheathment in central nervous system (GO:0032291)3.06592931
42central nervous system myelination (GO:0022010)3.06592931
43regulation of histone H3-K9 methylation (GO:0051570)3.06321855
44establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.99879395
45mitochondrion transport along microtubule (GO:0047497)2.99879395
46neuron recognition (GO:0008038)2.99595579
47regulation of synaptic vesicle exocytosis (GO:2000300)2.99090684
48axon extension involved in axon guidance (GO:0048846)2.97782141
49neuron projection extension involved in neuron projection guidance (GO:1902284)2.97782141
50mRNA splice site selection (GO:0006376)2.97653148
51regulation of oligodendrocyte differentiation (GO:0048713)2.95720888
52positive regulation of gene expression, epigenetic (GO:0045815)2.94915430
53negative regulation of histone methylation (GO:0031061)2.92883251
54dendrite morphogenesis (GO:0048813)2.92129880
55forebrain development (GO:0030900)2.91976928
56negative regulation of axon extension involved in axon guidance (GO:0048843)2.89597451
57mechanosensory behavior (GO:0007638)2.89533229
58DNA topological change (GO:0006265)2.89006526
59regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.87223159
60positive regulation of dendritic spine morphogenesis (GO:0061003)2.85951695
61hindbrain development (GO:0030902)2.82848257
62regulation of dendritic spine morphogenesis (GO:0061001)2.81887664
63positive regulation of oligodendrocyte differentiation (GO:0048714)2.81335061
64gamma-aminobutyric acid transport (GO:0015812)2.80811747
65negative regulation of cytosolic calcium ion concentration (GO:0051481)2.80134236
66negative regulation of axonogenesis (GO:0050771)2.80071881
67ionotropic glutamate receptor signaling pathway (GO:0035235)2.79812299
68regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.78516591
69spinal cord development (GO:0021510)2.78476211
70epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.78417444
71regulation of synapse maturation (GO:0090128)2.78202793
72neuromuscular synaptic transmission (GO:0007274)2.77705983
73negative regulation of microtubule polymerization (GO:0031115)2.75957248
74long-term memory (GO:0007616)2.73180882
75limb bud formation (GO:0060174)2.72023237
76central nervous system neuron axonogenesis (GO:0021955)2.71667870
77presynaptic membrane assembly (GO:0097105)2.70994050
78synaptic vesicle docking involved in exocytosis (GO:0016081)2.68882079
79regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.68020241
80cerebellum development (GO:0021549)2.67725892
81vesicle targeting (GO:0006903)2.66920989
82substrate-independent telencephalic tangential migration (GO:0021826)2.65940986
83substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.65940986
84synapse assembly (GO:0007416)2.64863951
85presynaptic membrane organization (GO:0097090)2.64019665
86startle response (GO:0001964)2.63498738
87nonmotile primary cilium assembly (GO:0035058)2.63134263
88regulation of neuronal synaptic plasticity (GO:0048168)2.63064831
89membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.61545672
90histone H3-K9 methylation (GO:0051567)2.61443498
91regulation of somitogenesis (GO:0014807)2.60447162
92transmission of nerve impulse (GO:0019226)2.60080082
93glial cell proliferation (GO:0014009)2.58901385
94cerebellar granule cell differentiation (GO:0021707)2.58624093
95neural tube development (GO:0021915)2.57379487
96cerebellar Purkinje cell differentiation (GO:0021702)2.57115569
97positive regulation of synaptic transmission, GABAergic (GO:0032230)2.56251184
98protein polyglutamylation (GO:0018095)2.56174056
99cerebral cortex radially oriented cell migration (GO:0021799)2.55730955
100forebrain neuron differentiation (GO:0021879)2.55496331
101G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.55096859
102adult walking behavior (GO:0007628)2.54837139
103glutamate receptor signaling pathway (GO:0007215)2.54242306
104synaptic transmission, glutamatergic (GO:0035249)2.50831444
105neuronal ion channel clustering (GO:0045161)2.50599760
106dendritic spine organization (GO:0097061)2.50049401
107positive regulation of membrane potential (GO:0045838)2.49888051
108cAMP catabolic process (GO:0006198)2.49807959
109sympathetic nervous system development (GO:0048485)2.49510584
110epithelial cilium movement (GO:0003351)2.49321980
111negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.48653185
112cilium movement (GO:0003341)2.48132346
113positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.47529285
114neurotransmitter secretion (GO:0007269)2.46981095
115negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.46957053
116regulation of long-term neuronal synaptic plasticity (GO:0048169)2.46929984
117auditory behavior (GO:0031223)2.46257685
118neuron-neuron synaptic transmission (GO:0007270)2.46240626
119neuroblast proliferation (GO:0007405)2.46101959
120regulation of synaptic vesicle transport (GO:1902803)2.45885687
121neurotransmitter-gated ion channel clustering (GO:0072578)2.45067463
122positive regulation of vascular permeability (GO:0043117)2.44888754
123response to auditory stimulus (GO:0010996)2.43444025
124hippocampus development (GO:0021766)2.42731472
125DNA unwinding involved in DNA replication (GO:0006268)2.42136084
126cyclic nucleotide catabolic process (GO:0009214)2.40638189
127cardiac ventricle formation (GO:0003211)2.39948592
128endocardial cushion morphogenesis (GO:0003203)2.39830843
129regulation of respiratory system process (GO:0044065)2.38821008
130retinal ganglion cell axon guidance (GO:0031290)2.38406619
131negative regulation of gene expression, epigenetic (GO:0045814)2.38400088
132spinal cord association neuron differentiation (GO:0021527)2.38060547
133neuronal action potential propagation (GO:0019227)2.37796266
134regulation of synapse structural plasticity (GO:0051823)2.36223103
135regulation of nuclear cell cycle DNA replication (GO:0033262)2.32149687
136regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.26774400
137neural tube formation (GO:0001841)2.25176732
138axonemal dynein complex assembly (GO:0070286)2.25074339
139behavioral defense response (GO:0002209)2.24516706
140behavioral fear response (GO:0001662)2.24516706
141somatic diversification of immune receptors via somatic mutation (GO:0002566)2.24334633
142somatic hypermutation of immunoglobulin genes (GO:0016446)2.24334633
143synaptic vesicle endocytosis (GO:0048488)2.23863924
144cilium or flagellum-dependent cell motility (GO:0001539)2.23704775
145microtubule depolymerization (GO:0007019)2.23641307
146neuron migration (GO:0001764)2.23091790
147cell proliferation in forebrain (GO:0021846)2.22831424
148regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.21583088
149regulation of action potential (GO:0098900)2.21512543
150cell differentiation in spinal cord (GO:0021515)2.20308400
151synaptic transmission, cholinergic (GO:0007271)2.20075337
152microtubule polymerization or depolymerization (GO:0031109)2.19175158
153cell differentiation in hindbrain (GO:0021533)2.17528609
154cranial nerve morphogenesis (GO:0021602)2.17463608

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.85067939
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.23969246
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.78362348
4* MYC_22102868_ChIP-Seq_BL_Human2.60629371
5EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60161080
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60161080
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.58151873
8E2F7_22180533_ChIP-Seq_HELA_Human2.51552556
9* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.45806539
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.44830423
11* RARB_27405468_Chip-Seq_BRAIN_Mouse2.41231374
12RNF2_27304074_Chip-Seq_ESCs_Mouse2.40215406
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.38798856
14DROSHA_22980978_ChIP-Seq_HELA_Human2.36749364
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.36349889
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.34608475
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.31248735
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.24418035
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.21562250
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.18156665
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.14411141
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.11823552
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.11719960
24REST_21632747_ChIP-Seq_MESCs_Mouse2.07509042
25IGF1R_20145208_ChIP-Seq_DFB_Human2.02843911
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.01885566
27RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.01191660
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.97589794
29TP63_19390658_ChIP-ChIP_HaCaT_Human1.91909629
30MTF2_20144788_ChIP-Seq_MESCs_Mouse1.91592598
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.91117455
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.84127333
33WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.83994553
34RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.83276085
35REST_18959480_ChIP-ChIP_MESCs_Mouse1.81076879
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80878032
37GBX2_23144817_ChIP-Seq_PC3_Human1.79668468
38* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76890407
39SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.76330360
40ZFP281_27345836_Chip-Seq_ESCs_Mouse1.76282733
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.76196992
42EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.74287466
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.74031428
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71972193
45* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.69773314
46KDM2B_26808549_Chip-Seq_K562_Human1.62562000
47RING1B_27294783_Chip-Seq_NPCs_Mouse1.59695615
48RING1B_27294783_Chip-Seq_ESCs_Mouse1.58198051
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.56463638
50VDR_21846776_ChIP-Seq_THP-1_Human1.52532579
51* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.51938878
52* KDM2B_26808549_Chip-Seq_DND41_Human1.48426885
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45925044
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.40027383
55* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.38550059
56AR_21572438_ChIP-Seq_LNCaP_Human1.38256082
57* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.37792081
58E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.37139585
59CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.34480464
60* KDM2B_26808549_Chip-Seq_JURKAT_Human1.33555789
61* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.31860230
62SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.31635177
63* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30514005
64CIITA_25753668_ChIP-Seq_RAJI_Human1.30268845
65SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28438354
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.26313096
67FUS_26573619_Chip-Seq_HEK293_Human1.24881311
68DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24867003
69ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23770010
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23313841
71RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22753927
72YAP1_20516196_ChIP-Seq_MESCs_Mouse1.20902661
73TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.20807496
74WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20599113
75SOX2_16153702_ChIP-ChIP_HESCs_Human1.19551517
76MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19348944
77GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16230117
78SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.15575593
79EWS_26573619_Chip-Seq_HEK293_Human1.14726886
80* TCF7_22412390_ChIP-Seq_EML_Mouse1.14400532
81ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13710603
82CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13229375
83* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.13018154
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12298752
85AR_19668381_ChIP-Seq_PC3_Human1.11585987
86RNF2_27304074_Chip-Seq_NSC_Mouse1.10059025
87ISL1_27105846_Chip-Seq_CPCs_Mouse1.09240264
88ARNT_22903824_ChIP-Seq_MCF-7_Human1.09167041
89HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.09029799
90POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06796391
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04966424
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04966424
93* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04926528
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03903281
95FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.03727099
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02684557
97E2F1_17053090_ChIP-ChIP_MCF-7_Human1.01940506
98MYC_18940864_ChIP-ChIP_HL60_Human1.01572225
99PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00685679
100E2F4_17652178_ChIP-ChIP_JURKAT_Human1.00619076
101IRF1_19129219_ChIP-ChIP_H3396_Human0.99973273
102AHR_22903824_ChIP-Seq_MCF-7_Human0.99904235
103GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98975105
104CTCF_27219007_Chip-Seq_Bcells_Human0.98762343
105TAF15_26573619_Chip-Seq_HEK293_Human0.96412114
106BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96356079
107VDR_22108803_ChIP-Seq_LS180_Human0.95853342
108SOX9_26525672_Chip-Seq_HEART_Mouse0.95187141
109P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94994768
110MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94450430
111WDR5_24793694_ChIP-Seq_LNCAP_Human0.93923467
112PKCTHETA_26484144_Chip-Seq_BREAST_Human0.92213638
113SOX2_21211035_ChIP-Seq_LN229_Gbm0.92103754
114SMAD3_21741376_ChIP-Seq_EPCs_Human0.90020696
115* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.89117219
116TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88217884
117* TCF4_23295773_ChIP-Seq_U87_Human0.87458094
118TP53_20018659_ChIP-ChIP_R1E_Mouse0.86933065
119SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86891467
120FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.84359540
121E2F1_21310950_ChIP-Seq_MCF-7_Human0.83891445
122THAP11_20581084_ChIP-Seq_MESCs_Mouse0.83383251
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83354596
124SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83170691
125GATA1_26923725_Chip-Seq_HPCs_Mouse0.83037776
126ZNF274_21170338_ChIP-Seq_K562_Hela0.82804388
127TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82014985
128RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.81310225
129SMAD3_21741376_ChIP-Seq_ESCs_Human0.81161289
130KDM5A_27292631_Chip-Seq_BREAST_Human0.80539106
131STAT3_23295773_ChIP-Seq_U87_Human0.79897340
132P300_19829295_ChIP-Seq_ESCs_Human0.79130614
133TP53_22573176_ChIP-Seq_HFKS_Human0.78331159
134NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.78251628
135TOP2B_26459242_ChIP-Seq_MCF-7_Human0.77198340
136IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.74942354
137CBP_20019798_ChIP-Seq_JUKART_Human0.74942354

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.66647587
2MP0003880_abnormal_central_pattern3.57243940
3MP0003635_abnormal_synaptic_transmissio2.85841695
4MP0000778_abnormal_nervous_system2.79844508
5MP0003787_abnormal_imprinting2.68290390
6MP0004270_analgesia2.53326794
7MP0005423_abnormal_somatic_nervous2.53310452
8MP0005499_abnormal_olfactory_system2.48893708
9MP0005394_taste/olfaction_phenotype2.48893708
10MP0002822_catalepsy2.33935361
11MP0002063_abnormal_learning/memory/cond2.31184855
12MP0008789_abnormal_olfactory_epithelium2.30267095
13MP0009745_abnormal_behavioral_response2.21279746
14MP0001984_abnormal_olfaction2.14155477
15MP0008961_abnormal_basal_metabolism2.14089316
16MP0002064_seizures2.14080358
17MP0004885_abnormal_endolymph2.06212935
18MP0001486_abnormal_startle_reflex1.98722186
19MP0001968_abnormal_touch/_nociception1.94883497
20MP0000569_abnormal_digit_pigmentation1.94479882
21MP0005645_abnormal_hypothalamus_physiol1.88594555
22MP0002572_abnormal_emotion/affect_behav1.84629638
23MP0000955_abnormal_spinal_cord1.83864236
24MP0000566_synostosis1.82981037
25MP0002184_abnormal_innervation1.75613815
26MP0002734_abnormal_mechanical_nocicepti1.70499472
27MP0003861_abnormal_nervous_system1.70473333
28MP0009780_abnormal_chondrocyte_physiolo1.69196349
29MP0008569_lethality_at_weaning1.68562793
30MP0004811_abnormal_neuron_physiology1.67485861
31MP0001529_abnormal_vocalization1.66479353
32MP0002067_abnormal_sensory_capabilities1.65102759
33MP0002557_abnormal_social/conspecific_i1.55536509
34MP0002152_abnormal_brain_morphology1.55116321
35MP0006292_abnormal_olfactory_placode1.53231377
36MP0002653_abnormal_ependyma_morphology1.49914578
37MP0002882_abnormal_neuron_morphology1.49751990
38MP0002272_abnormal_nervous_system1.47764647
39MP0002638_abnormal_pupillary_reflex1.46349144
40MP0003121_genomic_imprinting1.45286638
41MP0002751_abnormal_autonomic_nervous1.44168549
42MP0002736_abnormal_nociception_after1.44015990
43MP0000631_abnormal_neuroendocrine_gland1.42707273
44MP0008877_abnormal_DNA_methylation1.41843148
45MP0002735_abnormal_chemical_nociception1.37849509
46MP0009046_muscle_twitch1.36605068
47MP0005409_darkened_coat_color1.36600997
48MP0003890_abnormal_embryonic-extraembry1.36395058
49MP0008057_abnormal_DNA_replication1.32258056
50MP0001986_abnormal_taste_sensitivity1.32046389
51MP0003938_abnormal_ear_development1.27249262
52MP0005386_behavior/neurological_phenoty1.24336459
53MP0004924_abnormal_behavior1.24336459
54MP0001188_hyperpigmentation1.24285941
55MP0001346_abnormal_lacrimal_gland1.18053643
56MP0006276_abnormal_autonomic_nervous1.16570115
57MP0002249_abnormal_larynx_morphology1.15860616
58MP0004142_abnormal_muscle_tone1.15456517
59MP0002066_abnormal_motor_capabilities/c1.14010697
60MP0005187_abnormal_penis_morphology1.12785527
61MP0008058_abnormal_DNA_repair1.08719990
62MP0002234_abnormal_pharynx_morphology1.08679186
63MP0003136_yellow_coat_color1.08135751
64MP0001440_abnormal_grooming_behavior1.07968032
65MP0002733_abnormal_thermal_nociception1.07262796
66MP0005551_abnormal_eye_electrophysiolog1.07046638
67MP0003283_abnormal_digestive_organ1.04189938
68MP0008995_early_reproductive_senescence1.03607318
69MP0004043_abnormal_pH_regulation1.02988475
70MP0004145_abnormal_muscle_electrophysio1.01779275
71MP0002752_abnormal_somatic_nervous1.01278024
72MP0002928_abnormal_bile_duct1.00237112
73MP0000537_abnormal_urethra_morphology0.98581617
74MP0004742_abnormal_vestibular_system0.97953222
75MP0002102_abnormal_ear_morphology0.97176185
76MP0002081_perinatal_lethality0.97071825
77MP0001970_abnormal_pain_threshold0.95464159
78MP0010094_abnormal_chromosome_stability0.94816191
79MP0003122_maternal_imprinting0.94777653
80MP0000026_abnormal_inner_ear0.93727624
81MP0000372_irregular_coat_pigmentation0.91867808
82MP0006054_spinal_hemorrhage0.91848910
83MP0001502_abnormal_circadian_rhythm0.90168877
84MP0003111_abnormal_nucleus_morphology0.88021473
85MP0006072_abnormal_retinal_apoptosis0.87564495
86MP0003646_muscle_fatigue0.86996057
87MP0003937_abnormal_limbs/digits/tail_de0.86542080
88MP0000703_abnormal_thymus_morphology0.86306365
89MP0003119_abnormal_digestive_system0.86052232
90MP0005646_abnormal_pituitary_gland0.85132389
91MP0004133_heterotaxia0.85068087
92MP0010770_preweaning_lethality0.84230409
93MP0002082_postnatal_lethality0.84230409
94MP0003123_paternal_imprinting0.83763744
95MP0010769_abnormal_survival0.83619335
96MP0001293_anophthalmia0.81810733
97MP0002909_abnormal_adrenal_gland0.81434973
98MP0002163_abnormal_gland_morphology0.80983413
99MP0001963_abnormal_hearing_physiology0.80298566
100MP0010768_mortality/aging0.79333892
101MP0002009_preneoplasia0.79310685
102MP0003115_abnormal_respiratory_system0.77203051
103MP0003935_abnormal_craniofacial_develop0.77066686
104MP0005220_abnormal_exocrine_pancreas0.76797210
105MP0000462_abnormal_digestive_system0.76686993
106MP0002116_abnormal_craniofacial_bone0.76641255
107MP0001905_abnormal_dopamine_level0.76329572
108MP0005253_abnormal_eye_physiology0.76131837
109MP0001177_atelectasis0.75821183
110MP0001849_ear_inflammation0.75520060
111MP0001485_abnormal_pinna_reflex0.75502948
112MP0004233_abnormal_muscle_weight0.74966786
113MP0001943_abnormal_respiration0.74699584
114MP0002069_abnormal_eating/drinking_beha0.74633693
115MP0002233_abnormal_nose_morphology0.74252339
116MP0010386_abnormal_urinary_bladder0.73505780
117MP0010030_abnormal_orbit_morphology0.72769469
118MP0009278_abnormal_bone_marrow0.71903825
119MP0004134_abnormal_chest_morphology0.70627579
120MP0005076_abnormal_cell_differentiation0.69291814
121MP0001286_abnormal_eye_development0.66469082
122MP0002085_abnormal_embryonic_tissue0.66291562
123MP0000049_abnormal_middle_ear0.66269260
124MP0002092_abnormal_eye_morphology0.66217657
125MP0003879_abnormal_hair_cell0.65808541
126MP0000428_abnormal_craniofacial_morphol0.64845314
127MP0003631_nervous_system_phenotype0.64488438
128MP0002084_abnormal_developmental_patter0.63110449

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)4.88372620
2Abnormality of the intervertebral disk (HP:0005108)4.62615518
3Papilloma (HP:0012740)4.21606549
4Verrucae (HP:0200043)4.21606549
5Abnormality of B cell number (HP:0010975)3.83933832
6B lymphocytopenia (HP:0010976)3.83933832
7Thyroiditis (HP:0100646)3.78109219
8Small epiphyses (HP:0010585)3.50894241
9Vertebral arch anomaly (HP:0008438)3.44285180
10Cellulitis (HP:0100658)3.36766857
11Aqueductal stenosis (HP:0002410)3.16342909
12Myokymia (HP:0002411)3.00815342
13Focal motor seizures (HP:0011153)2.78652648
14Volvulus (HP:0002580)2.74554918
15Tented upper lip vermilion (HP:0010804)2.67085985
16Broad-based gait (HP:0002136)2.65620272
17Pancreatic cysts (HP:0001737)2.63675078
18Nephronophthisis (HP:0000090)2.62729741
19Focal seizures (HP:0007359)2.62553094
20Rib fusion (HP:0000902)2.57809394
21Hyperacusis (HP:0010780)2.53402802
22Panhypogammaglobulinemia (HP:0003139)2.48652410
23High anterior hairline (HP:0009890)2.48098621
24Severe combined immunodeficiency (HP:0004430)2.45282660
25Cutis marmorata (HP:0000965)2.43424796
26Gait imbalance (HP:0002141)2.41354657
27Ankyloglossia (HP:0010296)2.39659867
28Abnormality of midbrain morphology (HP:0002418)2.36292850
29Molar tooth sign on MRI (HP:0002419)2.36292850
30Bowel incontinence (HP:0002607)2.33535647
31Pancreatic fibrosis (HP:0100732)2.31317212
32Febrile seizures (HP:0002373)2.30039893
33Epileptic encephalopathy (HP:0200134)2.27979814
34Megalencephaly (HP:0001355)2.27777365
35Short 4th metacarpal (HP:0010044)2.26532742
36Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.26532742
37True hermaphroditism (HP:0010459)2.25541400
38Hyperventilation (HP:0002883)2.21116037
39Abnormality of the labia minora (HP:0012880)2.20534295
40Retinal dysplasia (HP:0007973)2.19861753
41Insomnia (HP:0100785)2.19840856
42Hypoplasia of the thymus (HP:0000778)2.19418815
43Abnormality of chromosome segregation (HP:0002916)2.18969048
44Lissencephaly (HP:0001339)2.18949218
45Medial flaring of the eyebrow (HP:0010747)2.18854518
46Obsessive-compulsive behavior (HP:0000722)2.18178987
47Elfin facies (HP:0004428)2.16898915
48Abnormality of the renal medulla (HP:0100957)2.16078809
49Abnormality of the fingertips (HP:0001211)2.15729550
50Thyroid-stimulating hormone excess (HP:0002925)2.13565632
51Pointed chin (HP:0000307)2.13344773
52Long eyelashes (HP:0000527)2.10857217
53Drooling (HP:0002307)2.10843979
54Excessive salivation (HP:0003781)2.10843979
55Generalized hypotonia (HP:0001290)2.09726138
56Abnormal respiratory motile cilium morphology (HP:0005938)2.08339623
57Abnormal respiratory epithelium morphology (HP:0012253)2.08339623
58Chronic hepatic failure (HP:0100626)2.08271109
59Acute lymphatic leukemia (HP:0006721)2.08267588
60Visual hallucinations (HP:0002367)2.07677887
61Abnormal large intestine physiology (HP:0012700)2.06639831
62Congenital primary aphakia (HP:0007707)2.04532405
63Genetic anticipation (HP:0003743)2.04190645
64Abnormal number of erythroid precursors (HP:0012131)2.04186652
65Increased nuchal translucency (HP:0010880)2.03958733
66Spina bifida occulta (HP:0003298)2.00751167
67Absence seizures (HP:0002121)1.98887169
68Sepsis (HP:0100806)1.98627656
69Hypoplasia of the capital femoral epiphysis (HP:0003090)1.98126516
70Overriding aorta (HP:0002623)1.98091592
71Abnormal number of incisors (HP:0011064)1.96038767
72Sclerocornea (HP:0000647)1.95615900
73Abnormality of cells of the erythroid lineage (HP:0012130)1.95276347
74Impulsivity (HP:0100710)1.95069315
75Abnormality of hair growth rate (HP:0011363)1.94445988
76Slow-growing hair (HP:0002217)1.94445988
77Widely spaced teeth (HP:0000687)1.94001009
78Pachygyria (HP:0001302)1.93435763
79Limited elbow extension (HP:0001377)1.92635654
80Poor coordination (HP:0002370)1.92110669
81Cystic liver disease (HP:0006706)1.91714691
82Dialeptic seizures (HP:0011146)1.90538143
83Autism (HP:0000717)1.89731517
84Stereotypic behavior (HP:0000733)1.89573504
85Patellar aplasia (HP:0006443)1.88537667
86Anosmia (HP:0000458)1.88470144
87Nephrogenic diabetes insipidus (HP:0009806)1.86708887
88Type II lissencephaly (HP:0007260)1.86693891
89Partial agenesis of the corpus callosum (HP:0001338)1.86194662
90Macroorchidism (HP:0000053)1.85605551
91Combined immunodeficiency (HP:0005387)1.85417336
92Oligodactyly (hands) (HP:0001180)1.85317792
93Morphological abnormality of the inner ear (HP:0011390)1.85157141
94Progressive cerebellar ataxia (HP:0002073)1.84898031
95Exotropia (HP:0000577)1.84847575
96Supranuclear gaze palsy (HP:0000605)1.84526163
97Renal duplication (HP:0000075)1.82991899
98Abnormality of cochlea (HP:0000375)1.82904349
99Protruding tongue (HP:0010808)1.82219903
100Neoplasm of the adrenal cortex (HP:0100641)1.81211842
101Abnormal ciliary motility (HP:0012262)1.78488060
102Aplasia/Hypoplasia of the uvula (HP:0010293)1.78296858
103Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.76869160
104Esophageal atresia (HP:0002032)1.76460850
105Trigonocephaly (HP:0000243)1.76452654
106Arthropathy (HP:0003040)1.75994637
107Amblyopia (HP:0000646)1.75699865
108Aplasia/Hypoplasia of the patella (HP:0006498)1.75651434
109Chronic sinusitis (HP:0011109)1.75465881
110Truncal ataxia (HP:0002078)1.73854463
111Hyperthyroidism (HP:0000836)1.72797390
112Vaginal atresia (HP:0000148)1.72723293
113Colon cancer (HP:0003003)1.72662088
114Preaxial hand polydactyly (HP:0001177)1.72262909
115Anencephaly (HP:0002323)1.72260421
116Cutaneous finger syndactyly (HP:0010554)1.71242641
117Short philtrum (HP:0000322)1.71218598
118Absent/shortened dynein arms (HP:0200106)1.70368960
119Dynein arm defect of respiratory motile cilia (HP:0012255)1.70368960
120Meningitis (HP:0001287)1.70119766
121Abnormal respiratory motile cilium physiology (HP:0012261)1.69921421
122Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.69157745
123Absent epiphyses (HP:0010577)1.69157745
124Intellectual disability, severe (HP:0010864)1.69127344
125Renovascular hypertension (HP:0100817)1.68964351
126Recurrent otitis media (HP:0000403)1.68930484
127Atonic seizures (HP:0010819)1.68774068
128Spastic gait (HP:0002064)1.68521208
129Thick eyebrow (HP:0000574)1.67934845
130Gaze-evoked nystagmus (HP:0000640)1.67444098
131Truncus arteriosus (HP:0001660)1.66901839
132Oligodactyly (HP:0012165)1.66749507
133Thickened helices (HP:0000391)1.66617268
134Genital tract atresia (HP:0001827)1.65702910
135Congenital stationary night blindness (HP:0007642)1.64928740
136Specific learning disability (HP:0001328)1.64306425
137Sparse scalp hair (HP:0002209)1.64209952
138Urinary bladder sphincter dysfunction (HP:0002839)1.63834665
139Asymmetry of the thorax (HP:0001555)1.63688458
140Abnormality of the right ventricle (HP:0001707)1.63640919
141Broad distal phalanx of finger (HP:0009836)1.62844383
142Neoplasm of the heart (HP:0100544)1.62534185
143Generalized tonic-clonic seizures (HP:0002069)1.62449179
144Abnormality of the 4th metacarpal (HP:0010012)1.62296278
145Pendular nystagmus (HP:0012043)1.62290686
146Flattened epiphyses (HP:0003071)1.62091464
147Abnormal drinking behavior (HP:0030082)1.60630194
148Polydipsia (HP:0001959)1.60630194
149Heterotopia (HP:0002282)1.60276135
150Postaxial foot polydactyly (HP:0001830)1.60198721
151External ear malformation (HP:0008572)1.60157212
152Optic nerve coloboma (HP:0000588)1.60129194
153Sacral dimple (HP:0000960)1.60093847
154Abnormality of oral frenula (HP:0000190)1.58889174
155Absent speech (HP:0001344)1.58634530
156Ankle clonus (HP:0011448)1.58471766
157Abnormality of salivation (HP:0100755)1.58043559
158Aplasia/Hypoplasia of the sternum (HP:0006714)1.58035430
159Cutaneous syndactyly (HP:0012725)1.57266584
160Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.56967206
161Papilledema (HP:0001085)1.55748591
162Status epilepticus (HP:0002133)1.55670091
163Chromsome breakage (HP:0040012)1.52137054
164Inability to walk (HP:0002540)1.51782189
165Deep palmar crease (HP:0006191)1.51737974
166Renal dysplasia (HP:0000110)1.51609004
167Polymicrogyria (HP:0002126)1.51544816
168Asplenia (HP:0001746)1.50483744
169Prominent nasal bridge (HP:0000426)1.49350751
170Chromosomal breakage induced by crosslinking agents (HP:0003221)1.49047942
171Tubulointerstitial nephritis (HP:0001970)1.47429415
172Birth length less than 3rd percentile (HP:0003561)1.47192258
173Abnormality of the diencephalon (HP:0010662)1.46855406

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K106.96923028
2MARK12.93169558
3SIK22.87530602
4FGFR22.76684809
5EEF2K2.31643553
6NTRK22.24513597
7FRK2.19835122
8MAPK132.13821410
9GRK62.13233225
10UHMK12.08050739
11KSR12.04442930
12EPHA42.03282878
13NTRK31.96042755
14BRD41.95693196
15TYRO31.79635578
16PINK11.78907176
17SIK31.64296982
18TLK11.56000916
19MAP3K41.49885996
20MINK11.48897171
21PRPF4B1.48561509
22ICK1.33545035
23CDK191.30019678
24WNK41.23189609
25CHEK21.20585814
26ATR1.16290642
27CLK11.14411517
28MELK1.13764259
29MKNK21.12906981
30BRSK11.12854443
31ERBB31.12754621
32BMPR1B1.12185920
33MAP4K21.12123540
34WNK11.11671354
35INSRR1.07396311
36PAK61.07257473
37CDK91.07032951
38CDK121.06833598
39CAMK1D1.06280437
40MAPK151.05643345
41MAP2K41.05625084
42FES1.04495035
43DAPK21.03811191
44FGFR31.00792019
45MAP3K71.00263124
46VRK20.99163523
47MAP3K90.98211915
48OXSR10.96577943
49DYRK1A0.96357756
50CAMK10.91260010
51ZAK0.90910316
52MARK20.90864059
53CDK50.90841928
54SGK4940.90280273
55SGK2230.90280273
56TNIK0.88958548
57CDK80.87591191
58NEK20.87099252
59MAP2K70.85422404
60CDK180.84777894
61RIPK40.84059629
62NUAK10.83175829
63PKN10.82552755
64CAMK40.81311415
65MKNK10.79424273
66STK110.78752784
67CDC42BPA0.78626729
68CDK150.78356985
69DYRK1B0.78098068
70SYK0.77589684
71CSNK1A1L0.77165387
72HIPK20.76219540
73DYRK20.74330308
74CAMKK10.74308158
75CDK140.72566146
76CDK11A0.72271403
77CSNK1G20.71785758
78VRK10.71552423
79BCR0.70776156
80CDK30.70527136
81PNCK0.70507223
82CDK40.70234606
83STK390.70065547
84CCNB10.69799721
85EPHB20.69491692
86CASK0.68656673
87PRKAA10.66934054
88GRK10.65910496
89SGK30.64772752
90CAMK1G0.63514273
91SRPK10.63374840
92SGK20.62688025
93CSNK1D0.62208718
94CSNK1G30.61725795
95MAPK110.61207156
96ADRBK20.60862262
97NTRK10.60691048
98BCKDK0.60125981
99DYRK30.58619003
100WNK30.58408558
101RET0.57506049
102RPS6KB10.57299260
103PRKCH0.56955960
104FYN0.56925620
105PRKCG0.56917403
106WEE10.56824447
107CSNK1A10.56772562
108CSNK1E0.56412205
109CDC70.56368538
110GSK3B0.56360134
111PASK0.55673290
112PRKD10.54767033
113ATM0.54320652
114TRIB30.53896105
115PAK30.52303167
116PRKCZ0.52078998
117ALK0.51583557
118TAF10.50484336
119RPS6KB20.49632647
120TRIM280.49566628
121PLK40.49205854
122TNK20.49159380
123PRKDC0.47191786
124CSNK1G10.46161192
125MAPK40.44652667
126PHKG10.44247862
127PHKG20.44247862
128MAPK120.43935302
129PRKD20.43366559
130SGK10.42875742
131ROCK20.41898989
132PLK20.41151405
133PRKD30.40512403
134CHEK10.40418448
135CDK20.40114524
136CDK10.39136634
137YES10.39015815

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047402.94199955
2Fanconi anemia pathway_Homo sapiens_hsa034602.18165514
3B cell receptor signaling pathway_Homo sapiens_hsa046622.13393741
4Morphine addiction_Homo sapiens_hsa050322.12849612
5Nicotine addiction_Homo sapiens_hsa050332.11115339
6Glutamatergic synapse_Homo sapiens_hsa047242.06011831
7Circadian entrainment_Homo sapiens_hsa047131.96715762
8Long-term potentiation_Homo sapiens_hsa047201.93889574
9Axon guidance_Homo sapiens_hsa043601.92116868
10Primary immunodeficiency_Homo sapiens_hsa053401.86488606
11Homologous recombination_Homo sapiens_hsa034401.81487698
12Dopaminergic synapse_Homo sapiens_hsa047281.81020500
13Glioma_Homo sapiens_hsa052141.80143584
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.75184572
15Alcoholism_Homo sapiens_hsa050341.74702543
16GABAergic synapse_Homo sapiens_hsa047271.74079626
17DNA replication_Homo sapiens_hsa030301.72599876
18Synaptic vesicle cycle_Homo sapiens_hsa047211.68866573
19Non-small cell lung cancer_Homo sapiens_hsa052231.64478508
20Notch signaling pathway_Homo sapiens_hsa043301.59025416
21Amphetamine addiction_Homo sapiens_hsa050311.58474282
22Cardiac muscle contraction_Homo sapiens_hsa042601.57853518
23Non-homologous end-joining_Homo sapiens_hsa034501.55669845
24Butanoate metabolism_Homo sapiens_hsa006501.54734644
25RNA polymerase_Homo sapiens_hsa030201.54176093
26Cholinergic synapse_Homo sapiens_hsa047251.53951319
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.49964907
28ErbB signaling pathway_Homo sapiens_hsa040121.46223607
29Ribosome_Homo sapiens_hsa030101.45647321
30Phosphatidylinositol signaling system_Homo sapiens_hsa040701.44976883
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.44305567
32Parkinsons disease_Homo sapiens_hsa050121.37454341
33Salivary secretion_Homo sapiens_hsa049701.37191493
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36263438
35Gastric acid secretion_Homo sapiens_hsa049711.32447652
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.31890037
37mRNA surveillance pathway_Homo sapiens_hsa030151.31582302
38Oxidative phosphorylation_Homo sapiens_hsa001901.28600991
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.26360492
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26307143
41Insulin secretion_Homo sapiens_hsa049111.26214344
42Oxytocin signaling pathway_Homo sapiens_hsa049211.25232181
43Long-term depression_Homo sapiens_hsa047301.25210900
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23607907
45Basal cell carcinoma_Homo sapiens_hsa052171.22394867
46Systemic lupus erythematosus_Homo sapiens_hsa053221.21574035
47Huntingtons disease_Homo sapiens_hsa050161.21184621
48Colorectal cancer_Homo sapiens_hsa052101.19462229
49Chronic myeloid leukemia_Homo sapiens_hsa052201.18960406
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18479673
51Type II diabetes mellitus_Homo sapiens_hsa049301.18137269
52Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.17907320
53Endometrial cancer_Homo sapiens_hsa052131.17716168
54Choline metabolism in cancer_Homo sapiens_hsa052311.16557411
55Thyroid hormone signaling pathway_Homo sapiens_hsa049191.15238983
56Hedgehog signaling pathway_Homo sapiens_hsa043401.14069935
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13327631
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11334315
59Basal transcription factors_Homo sapiens_hsa030221.10678652
60Gap junction_Homo sapiens_hsa045401.09591191
61Oocyte meiosis_Homo sapiens_hsa041141.08486528
62Sulfur relay system_Homo sapiens_hsa041221.08439743
63Dorso-ventral axis formation_Homo sapiens_hsa043201.08216787
64Wnt signaling pathway_Homo sapiens_hsa043101.08135256
65Neurotrophin signaling pathway_Homo sapiens_hsa047221.07419563
66Melanogenesis_Homo sapiens_hsa049161.07362416
67Phospholipase D signaling pathway_Homo sapiens_hsa040721.07006089
68One carbon pool by folate_Homo sapiens_hsa006701.06971781
69Taste transduction_Homo sapiens_hsa047421.06943274
70MicroRNAs in cancer_Homo sapiens_hsa052061.06767227
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.05002499
72GnRH signaling pathway_Homo sapiens_hsa049121.03308297
73Cocaine addiction_Homo sapiens_hsa050301.02067509
74mTOR signaling pathway_Homo sapiens_hsa041501.01825719
75Estrogen signaling pathway_Homo sapiens_hsa049151.01551782
76Serotonergic synapse_Homo sapiens_hsa047261.01301308
77Renin secretion_Homo sapiens_hsa049241.00661459
78Mismatch repair_Homo sapiens_hsa034300.99293083
79Calcium signaling pathway_Homo sapiens_hsa040200.95962495
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91102812
81cAMP signaling pathway_Homo sapiens_hsa040240.87306265
82Renal cell carcinoma_Homo sapiens_hsa052110.86902528
83Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85427406
84Lysine degradation_Homo sapiens_hsa003100.85106288
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84789514
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82856328
87Pancreatic cancer_Homo sapiens_hsa052120.82253839
88Linoleic acid metabolism_Homo sapiens_hsa005910.82084808
89MAPK signaling pathway_Homo sapiens_hsa040100.81101294
90FoxO signaling pathway_Homo sapiens_hsa040680.81031777
91Nitrogen metabolism_Homo sapiens_hsa009100.80885817
92Inositol phosphate metabolism_Homo sapiens_hsa005620.80446397
93Alzheimers disease_Homo sapiens_hsa050100.80383052
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78840181
95VEGF signaling pathway_Homo sapiens_hsa043700.78775588
96Spliceosome_Homo sapiens_hsa030400.75756222
97Hippo signaling pathway_Homo sapiens_hsa043900.74723240
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74032188
99Pyrimidine metabolism_Homo sapiens_hsa002400.74013861
100Cell cycle_Homo sapiens_hsa041100.72992819
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72270912
102RNA transport_Homo sapiens_hsa030130.71241865
103Base excision repair_Homo sapiens_hsa034100.70460475
104RNA degradation_Homo sapiens_hsa030180.69720636
105Nucleotide excision repair_Homo sapiens_hsa034200.68611009
106Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67248664
107AMPK signaling pathway_Homo sapiens_hsa041520.65027003
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63793559
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62970090
110Phototransduction_Homo sapiens_hsa047440.62803756
111T cell receptor signaling pathway_Homo sapiens_hsa046600.61881190
112Chemokine signaling pathway_Homo sapiens_hsa040620.61673944
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60683846
114Ras signaling pathway_Homo sapiens_hsa040140.60095507
115Purine metabolism_Homo sapiens_hsa002300.58564428
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58110301
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57172382
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56867140
119Prostate cancer_Homo sapiens_hsa052150.55726019
120Viral carcinogenesis_Homo sapiens_hsa052030.54992970
121Endocytosis_Homo sapiens_hsa041440.53759742
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53680573
123Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53119081
124Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52897583
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52803612
126Ether lipid metabolism_Homo sapiens_hsa005650.52516133
127Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50056007
128HTLV-I infection_Homo sapiens_hsa051660.49066718
129Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48037510
130Rap1 signaling pathway_Homo sapiens_hsa040150.47672896
131Melanoma_Homo sapiens_hsa052180.47644192
132Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47006872
133Maturity onset diabetes of the young_Homo sapiens_hsa049500.46643463
134Insulin signaling pathway_Homo sapiens_hsa049100.46007060
135Propanoate metabolism_Homo sapiens_hsa006400.45875985

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