BCL7B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the BCL7 family including BCL7A, BCL7B and BCL7C proteins. This member is BCL7B, which contains a region that is highly similar to the N-terminal segment of BCL7A or BCL7C proteins. The BCL7A protein is encoded by the gene known to be directly involved in a three-way gene translocation in a Burkitt lymphoma cell line. This gene is located at a chromosomal region commonly deleted in Williams syndrome. This gene is highly conserved from C. elegans to human. Multiple alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1purine nucleotide salvage (GO:0032261)7.11781998
2folic acid-containing compound biosynthetic process (GO:0009396)6.48388868
3regulation of plasminogen activation (GO:0010755)6.45451955
4homocysteine metabolic process (GO:0050667)6.08291092
5sulfur amino acid catabolic process (GO:0000098)5.92580526
6regulation of vitamin D biosynthetic process (GO:0060556)5.45868182
7RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.90523820
8tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.90523820
9cysteine metabolic process (GO:0006534)4.72485942
10white fat cell differentiation (GO:0050872)4.64854369
11epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.52031159
12regulation of vitamin metabolic process (GO:0030656)4.49586099
13adenosine metabolic process (GO:0046085)4.44583543
14nucleotide salvage (GO:0043173)4.38796243
15pteridine-containing compound biosynthetic process (GO:0042559)4.27177456
16DNA deamination (GO:0045006)4.24886299
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.21371005
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.21371005
19phosphatidylglycerol biosynthetic process (GO:0006655)4.17292142
20desmosome organization (GO:0002934)4.12807866
21negative regulation of DNA biosynthetic process (GO:2000279)4.10479448
22microtubule nucleation (GO:0007020)4.09447306
23cell migration involved in heart development (GO:0060973)4.05360844
24signal peptide processing (GO:0006465)4.04413325
25regulation of cholesterol storage (GO:0010885)3.99327294
26tolerance induction (GO:0002507)3.99078294
27antigen processing and presentation of endogenous antigen (GO:0019883)3.88999589
28alternative mRNA splicing, via spliceosome (GO:0000380)3.88471040
29positive regulation of endothelial cell differentiation (GO:0045603)3.68614551
30deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.62135688
31galactose catabolic process (GO:0019388)3.57768454
32proteasome assembly (GO:0043248)3.56279244
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.51960706
34glycosphingolipid catabolic process (GO:0046479)3.51371339
35positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.46155012
36positive regulation of gamma-delta T cell activation (GO:0046645)3.45729913
37regulation of superoxide anion generation (GO:0032928)3.42004240
38negative regulation of erythrocyte differentiation (GO:0045647)3.40281755
39negative regulation of catenin import into nucleus (GO:0035414)3.39773582
40negative regulation of cell size (GO:0045792)3.36237368
41sequestering of actin monomers (GO:0042989)3.34737090
42negative regulation of blood vessel endothelial cell migration (GO:0043537)3.30723048
43regulation of sequestering of triglyceride (GO:0010889)3.27241663
44regulation of tight junction assembly (GO:2000810)3.25164856
45IMP biosynthetic process (GO:0006188)3.21534209
46platelet dense granule organization (GO:0060155)3.21179773
47negative regulation of Ras GTPase activity (GO:0034261)3.19771466
48oxygen transport (GO:0015671)3.16999562
49regulation of gonadotropin secretion (GO:0032276)3.15579745
50purine-containing compound salvage (GO:0043101)3.14931246
51galactose metabolic process (GO:0006012)3.13762951
52glycolipid catabolic process (GO:0019377)3.13438727
53response to thyroid hormone (GO:0097066)3.11481170
54polyamine biosynthetic process (GO:0006596)3.07595157
55iron-sulfur cluster assembly (GO:0016226)3.07356623
56metallo-sulfur cluster assembly (GO:0031163)3.07356623
57cellular response to zinc ion (GO:0071294)3.06538070
58regulation of RIG-I signaling pathway (GO:0039535)3.05994566
59positive regulation of histone acetylation (GO:0035066)3.03400016
60endosome to pigment granule transport (GO:0043485)3.02587573
61endosome to melanosome transport (GO:0035646)3.02587573
62response to vitamin A (GO:0033189)3.02546717
63negative regulation of necroptotic process (GO:0060546)3.00073252
64NIK/NF-kappaB signaling (GO:0038061)2.97850909
65response to peptidoglycan (GO:0032494)2.97605608
66folic acid-containing compound metabolic process (GO:0006760)2.96775935
67mitochondrial RNA metabolic process (GO:0000959)2.96125727
68GDP-mannose metabolic process (GO:0019673)2.93051871
69L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.92983066
70negative regulation of lipid storage (GO:0010888)2.91563329
71cellular response to type I interferon (GO:0071357)2.89952968
72type I interferon signaling pathway (GO:0060337)2.89952968
73cytochrome complex assembly (GO:0017004)2.89948952
74negative regulation of interleukin-1 beta production (GO:0032691)2.88281554
75energy homeostasis (GO:0097009)2.87743301
76regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.87549747
77negative regulation of cAMP-mediated signaling (GO:0043951)2.87516026
78mast cell activation (GO:0045576)2.87496368
79negative regulation of cell killing (GO:0031342)2.87299060
80negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.87299060
81pathway-restricted SMAD protein phosphorylation (GO:0060389)2.87066581
82respiratory chain complex IV assembly (GO:0008535)2.86629770
83folic acid metabolic process (GO:0046655)2.86535202
84response to type I interferon (GO:0034340)2.86377538
85ribosomal small subunit assembly (GO:0000028)2.85239526
86regulation of relaxation of muscle (GO:1901077)2.84589655
87nucleoside diphosphate catabolic process (GO:0009134)2.82594120
88interferon-gamma production (GO:0032609)2.81812323
89IMP metabolic process (GO:0046040)2.79984212
90positive regulation of B cell differentiation (GO:0045579)2.77960385
91purine deoxyribonucleotide catabolic process (GO:0009155)2.76112868
92histone H4-K12 acetylation (GO:0043983)2.75059497
93regulation of DNA biosynthetic process (GO:2000278)2.74775854
94COPI coating of Golgi vesicle (GO:0048205)2.73102852
95Golgi transport vesicle coating (GO:0048200)2.73102852
96antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.72729801
97ceramide catabolic process (GO:0046514)2.71832128
98antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.71356294
99positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.70595161
100mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.70595161
101negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.69673317
102negative regulation of glycoprotein biosynthetic process (GO:0010561)2.69321042
103nucleoside transmembrane transport (GO:1901642)2.67501854
104folic acid transport (GO:0015884)2.66873113
105protein complex biogenesis (GO:0070271)2.65652540
106negative regulation of telomerase activity (GO:0051974)2.62200495
107oxidative phosphorylation (GO:0006119)2.61660550
108negative regulation of alcohol biosynthetic process (GO:1902931)2.60722970
109negative regulation of anoikis (GO:2000811)2.60718021
110regulation of gamma-delta T cell differentiation (GO:0045586)2.60182518
111regulation of B cell receptor signaling pathway (GO:0050855)2.58903313
112interferon-gamma-mediated signaling pathway (GO:0060333)2.58443622
113negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.57915224
114mitochondrial respiratory chain complex assembly (GO:0033108)2.57685797
115positive regulation of extracellular matrix organization (GO:1903055)2.57312042
116chaperone mediated protein folding requiring cofactor (GO:0051085)2.57245646
117glycoside metabolic process (GO:0016137)2.56090571
118neutrophil activation involved in immune response (GO:0002283)2.56074306
119tetrahydrofolate metabolic process (GO:0046653)2.56004059
120regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.55051059
121positive regulation of peptidyl-lysine acetylation (GO:2000758)2.54897154
122positive regulation of protein acetylation (GO:1901985)2.54897154
123regulation of anoikis (GO:2000209)2.53849425
124regulation of gamma-delta T cell activation (GO:0046643)2.53274573
125virion attachment to host cell (GO:0019062)2.53165901
126adhesion of symbiont to host cell (GO:0044650)2.53165901
127peptidyl-proline hydroxylation (GO:0019511)2.52143344
128regulation of necrotic cell death (GO:0010939)2.51316312
129negative regulation of interleukin-1 production (GO:0032692)2.50320994
130transcription elongation from RNA polymerase III promoter (GO:0006385)2.49672849
131termination of RNA polymerase III transcription (GO:0006386)2.49672849
132inner ear receptor cell development (GO:0060119)2.49270406
133positive regulation of triglyceride lipase activity (GO:0061365)2.49133860
134positive regulation of lipoprotein lipase activity (GO:0051006)2.49133860
135aminoglycoside antibiotic metabolic process (GO:0030647)2.48806619
136positive regulation of protein dephosphorylation (GO:0035307)2.48733858
137rRNA methylation (GO:0031167)2.47281701
138response to parathyroid hormone (GO:0071107)2.47236172
139negative regulation of phagocytosis (GO:0050765)2.45591853
140activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.45221779
141myeloid dendritic cell activation (GO:0001773)2.44899832
142antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.44221710
143regulation of endothelial cell differentiation (GO:0045601)2.43991666
1443-UTR-mediated mRNA stabilization (GO:0070935)2.43778256
145positive regulation of fatty acid metabolic process (GO:0045923)2.43417446
146T cell migration (GO:0072678)2.43219759
147negative regulation of necrotic cell death (GO:0060547)2.41790500
148regulation of superoxide metabolic process (GO:0090322)2.41656709
149mature B cell differentiation involved in immune response (GO:0002313)2.41336493
150heart process (GO:0003015)2.40087892
151heart contraction (GO:0060047)2.40087892
152positive regulation of mitochondrial fission (GO:0090141)2.39425316
153protein maturation by protein folding (GO:0022417)2.38856276
154regulation of interleukin-12 biosynthetic process (GO:0045075)2.38590706
155leukocyte aggregation (GO:0070486)2.37064593
156negative regulation of innate immune response (GO:0045824)2.34838001
157barbed-end actin filament capping (GO:0051016)2.34260988
158response to interferon-beta (GO:0035456)2.32238674
159positive regulation of antigen processing and presentation (GO:0002579)2.31830714
160peptidyl-histidine modification (GO:0018202)2.31793670
161cellular response to interferon-beta (GO:0035458)2.31742015
162fibril organization (GO:0097435)2.30490037
163defense response to protozoan (GO:0042832)2.30005578
164mast cell degranulation (GO:0043303)2.29884365
165mast cell activation involved in immune response (GO:0002279)2.29884365
166rRNA modification (GO:0000154)2.29390755
167Arp2/3 complex-mediated actin nucleation (GO:0034314)2.29379894
168myeloid dendritic cell differentiation (GO:0043011)2.27821305
169deoxyribonucleotide catabolic process (GO:0009264)2.27197349
170regulation of mitochondrial translation (GO:0070129)2.25596301
171regulation of T cell receptor signaling pathway (GO:0050856)2.25534090
172mitochondrial calcium ion homeostasis (GO:0051560)2.23394859
173positive regulation of mitochondrial membrane permeability (GO:0035794)2.21883389
174purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.20051328
175DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.19993673
176regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.18459476
177protein retention in ER lumen (GO:0006621)2.17999146
178negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.17001251
179regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.16183806
180positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.15877961
181positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.15865028
182response to protozoan (GO:0001562)2.15504290
183deoxyribose phosphate catabolic process (GO:0046386)2.14938742
184respiratory burst (GO:0045730)2.14769560
185regulation of response to interferon-gamma (GO:0060330)2.14551252
186telomere maintenance via semi-conservative replication (GO:0032201)2.14201713
187regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.13591457
188regulation of necroptotic process (GO:0060544)2.12984973
189signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.12737231

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.52532537
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.92010758
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.12478655
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.12158103
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.96670631
6* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.88667103
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.88295277
8RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.75513775
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.75112573
10LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.72538472
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.67041918
12LXR_22292898_ChIP-Seq_THP-1_Human2.58173420
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.57898215
14SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.56932980
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.53446183
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.53259116
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.50833451
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.49855012
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.47652546
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.40654418
21MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.34121883
22ELK3_25401928_ChIP-Seq_HUVEC_Human2.24281947
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.09493302
24ETS1_20019798_ChIP-Seq_JURKAT_Human2.04921334
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.04367114
26TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.02942462
27STAT4_19710469_ChIP-ChIP_TH1__Mouse1.98694422
28* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.97082665
29SCL_19346495_ChIP-Seq_HPC-7_Human1.96424989
30SPI1_23547873_ChIP-Seq_NB4_Human1.94297872
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.91475370
32* VDR_23849224_ChIP-Seq_CD4+_Human1.89328849
33* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.87077729
34ZNF263_19887448_ChIP-Seq_K562_Human1.84536951
35RACK7_27058665_Chip-Seq_MCF-7_Human1.82756838
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.81274486
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.79470310
38LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.78995876
39MYB_26560356_Chip-Seq_TH2_Human1.78832118
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.77763899
41EST1_17652178_ChIP-ChIP_JURKAT_Human1.77555144
42P68_20966046_ChIP-Seq_HELA_Human1.75707587
43ERG_20887958_ChIP-Seq_HPC-7_Mouse1.75592364
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72778846
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.71962063
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.71536152
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.68316335
48GATA1_22025678_ChIP-Seq_K562_Human1.68250385
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.67006927
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.66162385
51TCF7_22412390_ChIP-Seq_EML_Mouse1.65203026
52FOXP3_21729870_ChIP-Seq_TREG_Human1.65033977
53GABP_19822575_ChIP-Seq_HepG2_Human1.63087466
54GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.60856538
55MYC_22102868_ChIP-Seq_BL_Human1.59742855
56TP63_17297297_ChIP-ChIP_HaCaT_Human1.59242771
57MAF_26560356_Chip-Seq_TH1_Human1.58061009
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.56700496
59HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.56668406
60IRF8_27001747_Chip-Seq_BMDM_Mouse1.56467688
61SPI1_23127762_ChIP-Seq_K562_Human1.54890878
62DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.54520795
63* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.52901058
64THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51935397
65RUNX1_22412390_ChIP-Seq_EML_Mouse1.51786961
66VDR_21846776_ChIP-Seq_THP-1_Human1.51057319
67* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.50987775
68MYB_21317192_ChIP-Seq_ERMYB_Mouse1.50376868
69NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.49957504
70KDM2B_26808549_Chip-Seq_DND41_Human1.48570788
71BRD4_27068464_Chip-Seq_AML-cells_Mouse1.48136784
72RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.45526789
73NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45361608
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.45196921
75DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.44556064
76HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41656967
77FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.40393501
78BCL6_27268052_Chip-Seq_Bcells_Human1.38792318
79GATA1_22383799_ChIP-Seq_G1ME_Mouse1.38412410
80SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.38050370
81CIITA_25753668_ChIP-Seq_RAJI_Human1.37651134
82SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.35592204
83UTX_26944678_Chip-Seq_JUKART_Human1.35148635
84* NCOR1_26117541_ChIP-Seq_K562_Human1.34895769
85CTCF_18555785_ChIP-Seq_MESCs_Mouse1.34103696
86BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.33277342
87SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.32245798
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31907384
89CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31202782
90PU.1_20513432_ChIP-Seq_Bcells_Mouse1.31154473
91VDR_24763502_ChIP-Seq_THP-1_Human1.31125656
92SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30325018
93PPARA_22158963_ChIP-Seq_LIVER_Mouse1.28394189
94DCP1A_22483619_ChIP-Seq_HELA_Human1.28356604
95RXR_22158963_ChIP-Seq_LIVER_Mouse1.25576176
96CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25505078
97TFEB_21752829_ChIP-Seq_HELA_Human1.25169426
98PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24968016
99SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24932305
100ETS1_21867929_ChIP-Seq_TH2_Mouse1.24761176
101PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24631259
102SA1_27219007_Chip-Seq_ERYTHROID_Human1.24518287
103BP1_19119308_ChIP-ChIP_Hs578T_Human1.24160982
104* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.23973185
105RUNX_20019798_ChIP-Seq_JUKART_Human1.23917951
106SRY_22984422_ChIP-ChIP_TESTIS_Rat1.23036031
107TET1_21451524_ChIP-Seq_MESCs_Mouse1.22695371
108MAF_26560356_Chip-Seq_TH2_Human1.22477927
109IKZF1_21737484_ChIP-ChIP_HCT116_Human1.21771677
110CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21141155
111SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.21077693
112YY1_22570637_ChIP-Seq_MALME-3M_Human1.20032243
113MYB_26560356_Chip-Seq_TH1_Human1.19948068
114CREB1_15753290_ChIP-ChIP_HEK293T_Human1.19028268
115FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18906482
116* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.18408866
117EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.18291764
118KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.18101865
119MYC_18555785_ChIP-Seq_MESCs_Mouse1.16983274
120CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15381267
121STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.15063576
122ATF3_27146783_Chip-Seq_COLON_Human1.14943315
123ELF1_20517297_ChIP-Seq_JURKAT_Human1.14352214
124SMC4_20622854_ChIP-Seq_HELA_Human1.14197879
125TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13887254
126TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13845702
127CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13204934
128CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13064271
129TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13045197
130GATA2_22383799_ChIP-Seq_G1ME_Mouse1.12733295
131THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11326299
132TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10956788
133TBX5_21415370_ChIP-Seq_HL-1_Mouse1.10214665
134* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09765102
135CTCF_21964334_ChIP-Seq_BJAB-B_Human1.09643720
136KDM2B_26808549_Chip-Seq_JURKAT_Human1.09399322
137GATA1_19941827_ChIP-Seq_MEL_Mouse1.08495441
138* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08382605
139STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08225677
140UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07495408
141ESR2_21235772_ChIP-Seq_MCF-7_Human1.07352822
142BCOR_27268052_Chip-Seq_Bcells_Human1.07192862
143SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07148194
144* GATA3_27048872_Chip-Seq_THYMUS_Human1.07083732
145SA1_27219007_Chip-Seq_Bcells_Human1.06999497
146CTCF_26484167_Chip-Seq_Bcells_Mouse1.04618211
147STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04128373
148TP53_22127205_ChIP-Seq_IMR90_Human1.04063654
149CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.03981219
150CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02990566
151XRN2_22483619_ChIP-Seq_HELA_Human1.02316561
152SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01553728
153DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99901143
154* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99447378
155CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99377511
156CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99363086

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.95240232
2MP0005360_urolithiasis3.19234577
3MP0001835_abnormal_antigen_presentation2.89541140
4MP0005671_abnormal_response_to2.76135742
5MP0004185_abnormal_adipocyte_glucose2.70431340
6MP0001986_abnormal_taste_sensitivity2.55860360
7MP0009785_altered_susceptibility_to2.54658849
8MP0003763_abnormal_thymus_physiology2.45026422
9MP0003303_peritoneal_inflammation2.43150961
10MP0000685_abnormal_immune_system2.32480269
11MP0001790_abnormal_immune_system2.27805682
12MP0005387_immune_system_phenotype2.27805682
13MP0006054_spinal_hemorrhage2.27779364
14MP0002148_abnormal_hypersensitivity_rea2.22602199
15MP0003724_increased_susceptibility_to2.18113950
16MP0002837_dystrophic_cardiac_calcinosis2.10775884
17MP0005000_abnormal_immune_tolerance2.10203708
18MP0005670_abnormal_white_adipose2.00892643
19MP0002723_abnormal_immune_serum1.99277042
20MP0002420_abnormal_adaptive_immunity1.94698774
21MP0001819_abnormal_immune_cell1.92697304
22MP0005025_abnormal_response_to1.91765261
23MP0001800_abnormal_humoral_immune1.90182975
24MP0002452_abnormal_antigen_presenting1.89286778
25MP0005451_abnormal_body_composition1.87037849
26MP0001661_extended_life_span1.86917023
27MP0009333_abnormal_splenocyte_physiolog1.86868862
28MP0002419_abnormal_innate_immunity1.84291038
29MP0000013_abnormal_adipose_tissue1.78321156
30MP0008995_early_reproductive_senescence1.76948590
31MP0002877_abnormal_melanocyte_morpholog1.74910665
32MP0000003_abnormal_adipose_tissue1.74885026
33MP0004130_abnormal_muscle_cell1.74720607
34MP0003436_decreased_susceptibility_to1.73098706
35MP0002405_respiratory_system_inflammati1.72850049
36MP0004510_myositis1.69257826
37MP0002398_abnormal_bone_marrow1.67881635
38MP0002396_abnormal_hematopoietic_system1.67545614
39MP0003646_muscle_fatigue1.66962317
40MP0004947_skin_inflammation1.65710839
41MP0003183_abnormal_peptide_metabolism1.57689815
42MP0000716_abnormal_immune_system1.55259746
43MP0003186_abnormal_redox_activity1.50270851
44MP0006082_CNS_inflammation1.50127806
45MP0006036_abnormal_mitochondrial_physio1.49019371
46MP0002638_abnormal_pupillary_reflex1.48897468
47MP0003172_abnormal_lysosome_physiology1.48736201
48MP0000749_muscle_degeneration1.47950290
49MP0001542_abnormal_bone_strength1.46363126
50MP0002138_abnormal_hepatobiliary_system1.46089022
51MP0000681_abnormal_thyroid_gland1.43260390
52MP0001851_eye_inflammation1.41870045
53MP0000689_abnormal_spleen_morphology1.37008288
54MP0005666_abnormal_adipose_tissue1.36303280
55MP0002909_abnormal_adrenal_gland1.35963152
56MP0003806_abnormal_nucleotide_metabolis1.35770349
57MP0002429_abnormal_blood_cell1.34376166
58MP0000747_muscle_weakness1.32895211
59MP0001845_abnormal_inflammatory_respons1.31598199
60MP0005379_endocrine/exocrine_gland_phen1.30370849
61MP0005464_abnormal_platelet_physiology1.29784953
62MP0009278_abnormal_bone_marrow1.29324899
63MP0002722_abnormal_immune_system1.28741749
64MP0004084_abnormal_cardiac_muscle1.27411826
65MP0004147_increased_porphyrin_level1.26626999
66MP0005076_abnormal_cell_differentiation1.26477556
67MP0003191_abnormal_cellular_cholesterol1.26441858
68MP0000343_altered_response_to1.24292108
69MP0010155_abnormal_intestine_physiology1.23324855
70MP0005058_abnormal_lysosome_morphology1.23203689
71MP0000858_altered_metastatic_potential1.23148263
72MP0002139_abnormal_hepatobiliary_system1.23054814
73MP0000371_diluted_coat_color1.21400560
74MP0003828_pulmonary_edema1.19603762
75MP0001533_abnormal_skeleton_physiology1.18990110
76MP0005397_hematopoietic_system_phenotyp1.18740061
77MP0001545_abnormal_hematopoietic_system1.18740061
78MP0000750_abnormal_muscle_regeneration1.18391139
79MP0002693_abnormal_pancreas_physiology1.17862085
80MP0003279_aneurysm1.17379772
81MP0005645_abnormal_hypothalamus_physiol1.16888730
82MP0004036_abnormal_muscle_relaxation1.16275708
83MP0005375_adipose_tissue_phenotype1.14868180
84MP0009840_abnormal_foam_cell1.13529790
85MP0000678_abnormal_parathyroid_gland1.12867963
86MP0005646_abnormal_pituitary_gland1.09330399
87MP0002132_abnormal_respiratory_system1.09172665
88MP0004233_abnormal_muscle_weight1.07223037
89MP0000703_abnormal_thymus_morphology1.06908909
90MP0008469_abnormal_protein_level1.06432951
91MP0002933_joint_inflammation1.05512917
92MP0005330_cardiomyopathy1.04765221
93MP0003866_abnormal_defecation1.02892072
94MP0005164_abnormal_response_to1.01929297
95MP0003300_gastrointestinal_ulcer0.99192178
96MP0002163_abnormal_gland_morphology0.97503518
97MP0002653_abnormal_ependyma_morphology0.94500462
98MP0001958_emphysema0.92697156
99MP0005310_abnormal_salivary_gland0.92398310
100MP0005075_abnormal_melanosome_morpholog0.91255288
101MP0000230_abnormal_systemic_arterial0.90924536
102MP0001873_stomach_inflammation0.90531293
103MP0003221_abnormal_cardiomyocyte_apopto0.88847548
104MP0001984_abnormal_olfaction0.88844019
105MP0003656_abnormal_erythrocyte_physiolo0.87263818
106MP0008874_decreased_physiological_sensi0.86050313
107MP0001853_heart_inflammation0.85619709
108MP0005165_increased_susceptibility_to0.85579736
109MP0005332_abnormal_amino_acid0.84784924
110MP0005167_abnormal_blood-brain_barrier0.84734314
111MP0001502_abnormal_circadian_rhythm0.84624298
112MP0008007_abnormal_cellular_replicative0.84469379
113MP0005390_skeleton_phenotype0.84319455
114MP0010368_abnormal_lymphatic_system0.84120844
115MP0004808_abnormal_hematopoietic_stem0.83554585
116MP0001764_abnormal_homeostasis0.83178562
117MP0005319_abnormal_enzyme/_coenzyme0.82621276
118MP0009115_abnormal_fat_cell0.82361026
119MP0002332_abnormal_exercise_endurance0.81880979
120MP0009643_abnormal_urine_homeostasis0.81745252
121MP0004782_abnormal_surfactant_physiolog0.81038425
122MP0003075_altered_response_to0.81035371
123MP0005334_abnormal_fat_pad0.80963881
124MP0003453_abnormal_keratinocyte_physiol0.80445254
125MP0001944_abnormal_pancreas_morphology0.79529187
126MP0004215_abnormal_myocardial_fiber0.79427779
127MP0003943_abnormal_hepatobiliary_system0.79277042
128MP0008260_abnormal_autophagy0.79122182
129MP0009764_decreased_sensitivity_to0.79121938
130MP0003045_fibrosis0.78474067
131MP0002095_abnormal_skin_pigmentation0.77755319
132MP0000759_abnormal_skeletal_muscle0.77726962
133MP0002971_abnormal_brown_adipose0.77277281
134MP0009763_increased_sensitivity_to0.77237666
135MP0000249_abnormal_blood_vessel0.76984611
136MP0005166_decreased_susceptibility_to0.76457200
137MP0002998_abnormal_bone_remodeling0.76254107
138MP0004484_altered_response_of0.76112419
139MP0001544_abnormal_cardiovascular_syste0.75293738
140MP0005385_cardiovascular_system_phenoty0.75293738
141MP0010386_abnormal_urinary_bladder0.74111218
142MP0000490_abnormal_crypts_of0.73991671
143MP0001849_ear_inflammation0.73360711
144MP0004043_abnormal_pH_regulation0.72802055
145MP0003137_abnormal_impulse_conducting0.72120255
146MP0006292_abnormal_olfactory_placode0.68415479

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of alanine metabolism (HP:0010916)6.27460974
2Hyperalaninemia (HP:0003348)6.27460974
3Abnormality of pyruvate family amino acid metabolism (HP:0010915)6.27460974
4Spontaneous hematomas (HP:0007420)5.27855305
5Esophageal varix (HP:0002040)4.33834681
6Constricted visual fields (HP:0001133)4.19502048
7Myocardial infarction (HP:0001658)3.84819910
8Congenital sensorineural hearing impairment (HP:0008527)3.68772136
9Abnormality of the fetal cardiovascular system (HP:0010948)3.65729625
10Abnormal umbilical cord blood vessels (HP:0011403)3.65729625
11Single umbilical artery (HP:0001195)3.65729625
12Myopathic facies (HP:0002058)3.65534884
13Decreased activity of mitochondrial respiratory chain (HP:0008972)3.59696275
14Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.59696275
15Type I transferrin isoform profile (HP:0003642)3.45213126
16Anorexia (HP:0002039)3.26177323
17Vacuolated lymphocytes (HP:0001922)3.21121600
18White forelock (HP:0002211)3.19990064
19Recurrent abscess formation (HP:0002722)3.08273969
20Redundant skin (HP:0001582)3.08061675
21Conjunctival telangiectasia (HP:0000524)3.03945222
22Abnormal mitochondria in muscle tissue (HP:0008316)2.96986319
23Chronic otitis media (HP:0000389)2.91234735
24Abnormal protein glycosylation (HP:0012346)2.90569090
25Abnormal glycosylation (HP:0012345)2.90569090
26Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.90569090
27Abnormal protein N-linked glycosylation (HP:0012347)2.90569090
28Elevated erythrocyte sedimentation rate (HP:0003565)2.88286338
29Recurrent bronchitis (HP:0002837)2.88058761
30Reduced subcutaneous adipose tissue (HP:0003758)2.87927091
31Hepatocellular necrosis (HP:0001404)2.87407469
32Type 2 muscle fiber atrophy (HP:0003554)2.83238174
33Hepatic necrosis (HP:0002605)2.81979702
34Muscle fiber atrophy (HP:0100295)2.79247936
35Hypothermia (HP:0002045)2.77486085
36Pulmonary embolism (HP:0002204)2.77214356
37Acute necrotizing encephalopathy (HP:0006965)2.73659030
38Abnormality of the umbilical cord (HP:0010881)2.71291005
39Abnormality of the vasculature of the conjunctiva (HP:0008054)2.71147674
40Decreased electroretinogram (ERG) amplitude (HP:0000654)2.68715473
41Abnormality of the nasal mucosa (HP:0000433)2.67944530
42Loss of speech (HP:0002371)2.64876877
43Patchy hypopigmentation of hair (HP:0011365)2.64510933
44Myositis (HP:0100614)2.63929531
45Oligomenorrhea (HP:0000876)2.62858251
46Neuroendocrine neoplasm (HP:0100634)2.57703174
47Mitochondrial inheritance (HP:0001427)2.57422639
48Polygenic inheritance (HP:0010982)2.55444233
49Abnormal delayed hypersensitivity skin test (HP:0002963)2.54814999
50Progressive neurologic deterioration (HP:0002344)2.50452235
51Hypertensive crisis (HP:0100735)2.50059528
52Easy fatigability (HP:0003388)2.48737550
53Hypergammaglobulinemia (HP:0010702)2.48545478
54Nasal polyposis (HP:0100582)2.44408445
55Aortic valve stenosis (HP:0001650)2.44010018
56Abnormality of homocysteine metabolism (HP:0010919)2.41566997
57Homocystinuria (HP:0002156)2.41566997
58Increased IgM level (HP:0003496)2.41086416
59Pheochromocytoma (HP:0002666)2.40366876
60Pustule (HP:0200039)2.39893553
61Hypoalphalipoproteinemia (HP:0003233)2.36597268
62Petechiae (HP:0000967)2.36190387
63IgM deficiency (HP:0002850)2.35505655
64Growth hormone excess (HP:0000845)2.35260548
65Dysostosis multiplex (HP:0000943)2.33730929
66Increased cerebral lipofuscin (HP:0011813)2.33363485
67Panhypogammaglobulinemia (HP:0003139)2.33178696
68Abnormality of macrophages (HP:0004311)2.32221195
69Abnormal rod and cone electroretinograms (HP:0008323)2.30753195
70Ileus (HP:0002595)2.30309111
71Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.28825109
72Action tremor (HP:0002345)2.26554720
73Biconcave vertebral bodies (HP:0004586)2.26144933
74Increased muscle lipid content (HP:0009058)2.25977726
75Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.24700668
76Poor speech (HP:0002465)2.24039095
77Increased CSF lactate (HP:0002490)2.22770279
78Visceral angiomatosis (HP:0100761)2.22707422
79Absent rod-and cone-mediated responses on ERG (HP:0007688)2.21087305
80Heterochromia iridis (HP:0001100)2.20820323
81Granulocytopenia (HP:0001913)2.20277786
82Abnormality of glycolipid metabolism (HP:0010969)2.19985412
83Abnormality of liposaccharide metabolism (HP:0010968)2.19985412
84Abnormality of glycosphingolipid metabolism (HP:0004343)2.19985412
85Mediastinal lymphadenopathy (HP:0100721)2.19932842
86Decreased subcutaneous fat (HP:0001002)2.18578373
87Bronchitis (HP:0012387)2.18435482
88Aplastic anemia (HP:0001915)2.18309236
89Exercise intolerance (HP:0003546)2.17863025
90Recurrent bacterial skin infections (HP:0005406)2.17452630
91Urinary glycosaminoglycan excretion (HP:0003541)2.17158313
92Mucopolysacchariduria (HP:0008155)2.17158313
93Elevated alkaline phosphatase (HP:0003155)2.15277015
94Increased neuronal autofluorescent lipopigment (HP:0002074)2.15023879
95IgG deficiency (HP:0004315)2.10672592
96Joint stiffness (HP:0001387)2.10648486
97Abnormality of T cell physiology (HP:0011840)2.09991693
98Abnormality of polysaccharide metabolism (HP:0011012)2.09784644
99Abnormality of glycosaminoglycan metabolism (HP:0004371)2.09784644
100Abnormality of mucopolysaccharide metabolism (HP:0011020)2.09784644
101Conjugated hyperbilirubinemia (HP:0002908)2.08846103
102Increased intramyocellular lipid droplets (HP:0012240)2.08761223
103Chronic sinusitis (HP:0011109)2.08608869
104Gastrointestinal stroma tumor (HP:0100723)2.07977468
105Abnormality of T cells (HP:0002843)2.07772088
106Recurrent fungal infections (HP:0002841)2.06675968
107Cervical subluxation (HP:0003308)2.06496087
108Neoplasm of head and neck (HP:0012288)2.06040592
109Esophageal neoplasm (HP:0100751)2.06040592
110Systemic lupus erythematosus (HP:0002725)2.05995095
111Gingival bleeding (HP:0000225)2.05772483
112Diaphragmatic weakness (HP:0009113)2.04932195
113Basal ganglia calcification (HP:0002135)2.04499192
114Increased serum lactate (HP:0002151)2.03505722
115Back pain (HP:0003418)2.03420592
116Arterial thrombosis (HP:0004420)2.03215250
117Agammaglobulinemia (HP:0004432)2.02563087
1183-Methylglutaconic aciduria (HP:0003535)2.01725858
119Eczematoid dermatitis (HP:0000976)2.00905635
120Generalized aminoaciduria (HP:0002909)2.00712395
121Abnormality of alkaline phosphatase activity (HP:0004379)2.00314915
122Recurrent cutaneous fungal infections (HP:0011370)1.99238900
123Chronic mucocutaneous candidiasis (HP:0002728)1.99238900
124Nausea (HP:0002018)1.99216859
125Abnormal enzyme/coenzyme activity (HP:0012379)1.99102534
126Hypoplastic left heart (HP:0004383)1.98614002
127Vertebral compression fractures (HP:0002953)1.98083686
128Recurrent viral infections (HP:0004429)1.97916238
129Cortical visual impairment (HP:0100704)1.97108381
130Lactic acidosis (HP:0003128)1.97087833
131Toxemia of pregnancy (HP:0100603)1.95429397
132Purpura (HP:0000979)1.95057658
133Axonal loss (HP:0003447)1.94904731
134Reduced antithrombin III activity (HP:0001976)1.94561545
135Cavernous hemangioma (HP:0001048)1.94269760
136Emphysema (HP:0002097)1.93981895
137Stomatitis (HP:0010280)1.93971793
138Nonprogressive disorder (HP:0003680)1.93364417
139Ragged-red muscle fibers (HP:0003200)1.93354975
140Palpitations (HP:0001962)1.92995491
141Acute encephalopathy (HP:0006846)1.92521247
142Hypertriglyceridemia (HP:0002155)1.92170094
143Progressive muscle weakness (HP:0003323)1.92077665
144Insulin-resistant diabetes mellitus (HP:0000831)1.91273569
145Patent foramen ovale (HP:0001655)1.90252102
146Distal lower limb amyotrophy (HP:0008944)1.89877760
147Urticaria (HP:0001025)1.89738683
148Bulbar palsy (HP:0001283)1.89695416
149Papilledema (HP:0001085)1.89266921
150Fatigue (HP:0012378)1.89098459
151Thrombophlebitis (HP:0004418)1.88892259
152Progressive macrocephaly (HP:0004481)1.88805969
153Abnormality of dental color (HP:0011073)1.87947435
154Hemangiomatosis (HP:0007461)1.87295641
155Large for gestational age (HP:0001520)1.86891497
156Beaking of vertebral bodies (HP:0004568)1.86624042
157Epistaxis (HP:0000421)1.86147477
158Abnormality of T cell number (HP:0011839)1.84527118
159Abnormality of the phalanges of the hallux (HP:0010057)1.84272179
160Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.84218105
161Retinal dysplasia (HP:0007973)1.82541794
162Thin bony cortex (HP:0002753)1.82132803
163Distal lower limb muscle weakness (HP:0009053)1.80577150
164Abnormality of the peritoneum (HP:0002585)1.80353445
165Microcytic anemia (HP:0001935)1.80258747
166Spinal canal stenosis (HP:0003416)1.78689064
167Dilated cardiomyopathy (HP:0001644)1.77842412
168Hemoptysis (HP:0002105)1.77397924
169Gastrointestinal dysmotility (HP:0002579)1.76892686
170Abnormality of the anterior horn cell (HP:0006802)1.76886285
171Degeneration of anterior horn cells (HP:0002398)1.76886285
172T lymphocytopenia (HP:0005403)1.75929248
173Abnormality of B cell number (HP:0010975)1.75759491
174B lymphocytopenia (HP:0010976)1.75759491
175Severe combined immunodeficiency (HP:0004430)1.75646230
176Birth length less than 3rd percentile (HP:0003561)1.75479135
177Restrictive lung disease (HP:0002091)1.73018240
178Difficulty climbing stairs (HP:0003551)1.71960251
179Increased serum ferritin (HP:0003281)1.67248060
180Insomnia (HP:0100785)1.66828499
181Increased IgE level (HP:0003212)1.65581110

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K35.11938372
2TRIB32.91106952
3MAP4K12.91021384
4NME22.80350636
5TBK12.70719648
6PIM22.69155489
7IRAK32.41780843
8IRAK42.32602095
9CAMKK22.30620727
10TXK2.30448670
11KIT2.26794707
12SIK32.25357541
13MAPK152.21885021
14TAOK22.08356497
15ARAF2.06844336
16ACVR1B2.04351449
17MAP3K142.02440325
18FLT31.97831127
19TEC1.96127967
20ZAP701.93334797
21PINK11.92227810
22MAP3K121.91541326
23CDK91.90990701
24CCNB11.88302219
25KDR1.85379075
26TGFBR21.83887799
27SIK11.80714264
28BCKDK1.79194278
29MYLK1.76625992
30ERN11.73278914
31FGR1.72933295
32IKBKE1.65583007
33RPS6KB21.65563767
34STK161.65271130
35JAK31.63218924
36MAP3K131.60787307
37SMG11.56774072
38BTK1.54418005
39IKBKB1.35459237
40TIE11.31383053
41MAP3K111.29973744
42PRKD31.29331606
43TAOK11.26698706
44NLK1.26045494
45EIF2AK11.24014468
46EPHA31.23346621
47TESK21.21794412
48TTN1.14355056
49SYK1.13626755
50TYK21.12383385
51CDK81.07964797
52MOS1.07675098
53NME11.07543275
54ITK1.04794831
55HIPK21.04389868
56BMPR21.01211639
57MAPK110.95118815
58TNK20.93111707
59EPHB20.92325214
60MUSK0.91917430
61BRSK20.91690839
62MATK0.90843478
63PAK40.90056943
64GRK60.83986066
65PASK0.83259620
66PTK60.82887762
67MAP2K10.82663165
68INSRR0.82210196
69SGK4940.81592023
70SGK2230.81592023
71PRKCI0.81166718
72IRAK10.80262095
73GRK70.80024348
74ICK0.78709420
75MAPKAPK30.77239593
76SGK30.76788433
77TESK10.75960446
78MAP2K70.75118952
79RPS6KA60.74448364
80NEK90.73674134
81PRKCH0.72247085
82CSF1R0.69854827
83NTRK20.69312256
84EPHA20.68846893
85LMTK20.68536649
86KSR20.68258713
87PRKG20.67231527
88TNIK0.66936421
89PRKD20.65911651
90MAP2K20.65563793
91DAPK10.65552775
92RPS6KA40.63770929
93RPS6KL10.62995472
94RPS6KC10.62995472
95CAMKK10.62145543
96LCK0.61825053
97MARK30.61642558
98TSSK60.61631518
99MAPK120.61438049
100LYN0.61223107
101VRK10.60572969
102SGK20.59545601
103MAP3K30.59351706
104TYRO30.58753941
105MAP3K60.58741855
106MAP3K90.58675907
107PIK3CG0.57971184
108PKN20.57137899
109CDK190.56583730
110DAPK30.56554005
111PDK20.55930927
112MTOR0.55817187
113RIPK40.55627985
114CAMK10.55452959
115WNK30.55045209
116SIK20.54194965
117LRRK20.54121717
118RIPK10.53691400
119IRAK20.53414897
120PDPK10.52972168
121MAP3K10.52916092
122PRKCD0.52636311
123PIM10.52348714
124DAPK20.51901167
125BRAF0.51752503
126ABL20.51080049
127RAF10.49730915
128FES0.49487633
129STK240.49050757
130MAPK70.46089263
131PRPF4B0.46016946
132TAOK30.45488015
133JAK20.45375158
134CAMK2G0.45271185
135ADRBK20.45099840
136ADRBK10.43904626
137BRSK10.43795300
138JAK10.43035841
139TGFBR10.42905545
140MAPKAPK20.42536556
141VRK20.41170916
142PHKG10.40639550
143PHKG20.40639550
144LIMK10.40363436
145RPS6KA20.39917232
146CSK0.38576326
147ZAK0.37526622
148BLK0.37482021
149RPS6KA10.36621417
150STK100.35596203
151MARK20.35356968
152MAP3K80.35079741
153BRD40.34943308
154CHUK0.34726759
155CDK40.34429212

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.35412866
2Protein export_Homo sapiens_hsa030602.95875783
3Other glycan degradation_Homo sapiens_hsa005112.73798519
4SNARE interactions in vesicular transport_Homo sapiens_hsa041302.64416910
5Arginine biosynthesis_Homo sapiens_hsa002202.62910481
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.58825817
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.41017283
8Proteasome_Homo sapiens_hsa030502.39983713
9Primary immunodeficiency_Homo sapiens_hsa053402.39381938
10One carbon pool by folate_Homo sapiens_hsa006702.32640782
11Sulfur metabolism_Homo sapiens_hsa009202.28924443
12DNA replication_Homo sapiens_hsa030302.26918204
13RNA polymerase_Homo sapiens_hsa030202.12149415
14Oxidative phosphorylation_Homo sapiens_hsa001902.04340225
15Parkinsons disease_Homo sapiens_hsa050121.97935093
16Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.77126870
17Lysosome_Homo sapiens_hsa041421.72645937
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.70877232
19Base excision repair_Homo sapiens_hsa034101.66049421
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.64330284
21Prion diseases_Homo sapiens_hsa050201.61563764
22Legionellosis_Homo sapiens_hsa051341.56245042
23Pyrimidine metabolism_Homo sapiens_hsa002401.52559168
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.50039613
25Ribosome_Homo sapiens_hsa030101.48509772
26Antigen processing and presentation_Homo sapiens_hsa046121.48102116
27Mismatch repair_Homo sapiens_hsa034301.47660668
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.47048618
29Rheumatoid arthritis_Homo sapiens_hsa053231.45708945
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.38787800
31Huntingtons disease_Homo sapiens_hsa050161.31339280
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.30480678
33Purine metabolism_Homo sapiens_hsa002301.30192657
34Regulation of autophagy_Homo sapiens_hsa041401.29434431
35Measles_Homo sapiens_hsa051621.26928040
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.25661131
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.24157135
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.21372084
39Alzheimers disease_Homo sapiens_hsa050101.20173528
40VEGF signaling pathway_Homo sapiens_hsa043701.17322327
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.17021874
42Type I diabetes mellitus_Homo sapiens_hsa049401.16252435
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.15902466
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.14960742
45Nucleotide excision repair_Homo sapiens_hsa034201.11455566
46Bladder cancer_Homo sapiens_hsa052191.09444150
47Cardiac muscle contraction_Homo sapiens_hsa042601.09253431
48Biosynthesis of amino acids_Homo sapiens_hsa012301.08818391
49Toll-like receptor signaling pathway_Homo sapiens_hsa046201.08069301
50Leishmaniasis_Homo sapiens_hsa051401.05394813
51Vibrio cholerae infection_Homo sapiens_hsa051101.05361022
52Morphine addiction_Homo sapiens_hsa050321.04004228
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.03244057
54Galactose metabolism_Homo sapiens_hsa000521.02856904
55Allograft rejection_Homo sapiens_hsa053301.02586934
56Hematopoietic cell lineage_Homo sapiens_hsa046401.00668517
57Vitamin B6 metabolism_Homo sapiens_hsa007500.99969206
58Osteoclast differentiation_Homo sapiens_hsa043800.97703961
59Olfactory transduction_Homo sapiens_hsa047400.97331862
60Collecting duct acid secretion_Homo sapiens_hsa049660.96193689
61Longevity regulating pathway - mammal_Homo sapiens_hsa042110.94442383
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.94382210
63Insulin secretion_Homo sapiens_hsa049110.94185830
64Homologous recombination_Homo sapiens_hsa034400.92983851
65Shigellosis_Homo sapiens_hsa051310.92324521
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.91979900
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.91162855
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90107348
69Graft-versus-host disease_Homo sapiens_hsa053320.89487271
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85597857
71B cell receptor signaling pathway_Homo sapiens_hsa046620.85593725
72GABAergic synapse_Homo sapiens_hsa047270.83899172
73Herpes simplex infection_Homo sapiens_hsa051680.81687766
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79610814
75Chronic myeloid leukemia_Homo sapiens_hsa052200.79574881
76Pertussis_Homo sapiens_hsa051330.78994130
77N-Glycan biosynthesis_Homo sapiens_hsa005100.78792305
78Acute myeloid leukemia_Homo sapiens_hsa052210.78783162
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.78664763
80GnRH signaling pathway_Homo sapiens_hsa049120.77614511
81Synaptic vesicle cycle_Homo sapiens_hsa047210.77472905
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77056169
83Fructose and mannose metabolism_Homo sapiens_hsa000510.76101208
84Apoptosis_Homo sapiens_hsa042100.74932820
85Circadian rhythm_Homo sapiens_hsa047100.74834146
86Selenocompound metabolism_Homo sapiens_hsa004500.73838805
87Tuberculosis_Homo sapiens_hsa051520.72197129
88Non-small cell lung cancer_Homo sapiens_hsa052230.72084787
89Renal cell carcinoma_Homo sapiens_hsa052110.70704604
90Epstein-Barr virus infection_Homo sapiens_hsa051690.69347647
91Folate biosynthesis_Homo sapiens_hsa007900.69152831
92Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68805393
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67349279
94Autoimmune thyroid disease_Homo sapiens_hsa053200.65980925
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65668155
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65136209
97Hepatitis C_Homo sapiens_hsa051600.64616766
98Staphylococcus aureus infection_Homo sapiens_hsa051500.64518069
99Arachidonic acid metabolism_Homo sapiens_hsa005900.62464644
100Malaria_Homo sapiens_hsa051440.61745633
101Phagosome_Homo sapiens_hsa041450.60766959
102Dilated cardiomyopathy_Homo sapiens_hsa054140.60315280
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58152647
104Influenza A_Homo sapiens_hsa051640.57446589
105TNF signaling pathway_Homo sapiens_hsa046680.57280140
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57058182
107Chemokine signaling pathway_Homo sapiens_hsa040620.56453353
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56427076
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56184366
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54369748
111African trypanosomiasis_Homo sapiens_hsa051430.51909734
112Cholinergic synapse_Homo sapiens_hsa047250.51840432
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.51787334
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.50151573
115Thyroid cancer_Homo sapiens_hsa052160.49958573
116Hepatitis B_Homo sapiens_hsa051610.49469744
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49129824
118Pancreatic cancer_Homo sapiens_hsa052120.48897241
119Pentose phosphate pathway_Homo sapiens_hsa000300.47892797
120Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45955680
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45708300
122T cell receptor signaling pathway_Homo sapiens_hsa046600.45192102
123Endocytosis_Homo sapiens_hsa041440.44688667
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.44645599
125Cysteine and methionine metabolism_Homo sapiens_hsa002700.44610137
126Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.43844593
127Salmonella infection_Homo sapiens_hsa051320.43029700
128RNA degradation_Homo sapiens_hsa030180.42821376
129Spliceosome_Homo sapiens_hsa030400.42412309
130Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41503523
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41342909
132Basal transcription factors_Homo sapiens_hsa030220.40326102
133AMPK signaling pathway_Homo sapiens_hsa041520.40121429
134Sphingolipid metabolism_Homo sapiens_hsa006000.39994869
135Calcium signaling pathway_Homo sapiens_hsa040200.35907549
136HIF-1 signaling pathway_Homo sapiens_hsa040660.35268372
137Toxoplasmosis_Homo sapiens_hsa051450.35014677
138Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33588030
139Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33532299
140HTLV-I infection_Homo sapiens_hsa051660.33409826
141Viral myocarditis_Homo sapiens_hsa054160.31996518

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