BCL7C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is identified by the similarity of its product to the N-terminal region of BCL7A protein. The BCL7A protein is encoded by the gene known to be directly involved in a three-way gene translocation in a Burkitt lymphoma cell line. The function of this gene has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.16509859
2viral transcription (GO:0019083)5.15644009
3translational termination (GO:0006415)4.94129607
4negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.90141865
5ribosomal small subunit biogenesis (GO:0042274)4.42921751
6translational elongation (GO:0006414)4.27722079
7nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.15607232
8tooth mineralization (GO:0034505)4.13141400
9UV protection (GO:0009650)4.07838103
10GDP-mannose metabolic process (GO:0019673)4.04997927
11maturation of SSU-rRNA (GO:0030490)4.04343460
12microtubule depolymerization (GO:0007019)4.02724650
13lymph vessel development (GO:0001945)4.00315060
14translational initiation (GO:0006413)3.95366396
15deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.94487103
16positive regulation of prostaglandin secretion (GO:0032308)3.93393314
17cellular protein complex disassembly (GO:0043624)3.89250066
18regulation of apoptotic process involved in morphogenesis (GO:1902337)3.86938185
19protein complex disassembly (GO:0043241)3.78272545
20SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.74738946
21kinetochore assembly (GO:0051382)3.74554609
22positive regulation of hair cycle (GO:0042635)3.74416246
23positive regulation of hair follicle development (GO:0051798)3.74416246
24viral life cycle (GO:0019058)3.74042117
25protein K6-linked ubiquitination (GO:0085020)3.66452835
26cotranslational protein targeting to membrane (GO:0006613)3.61675261
27protein targeting to ER (GO:0045047)3.61380579
28kinetochore organization (GO:0051383)3.58352401
29meiotic chromosome segregation (GO:0045132)3.54373116
30macromolecular complex disassembly (GO:0032984)3.44499836
31protein localization to kinetochore (GO:0034501)3.44029057
32DNA damage response, signal transduction resulting in transcription (GO:0042772)3.43737804
33DNA unwinding involved in DNA replication (GO:0006268)3.42467547
34establishment of protein localization to endoplasmic reticulum (GO:0072599)3.42100157
35negative regulation of RNA splicing (GO:0033119)3.40587345
36negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.40022062
37autophagic vacuole fusion (GO:0000046)3.39716959
38mitotic chromosome condensation (GO:0007076)3.39103594
39establishment of integrated proviral latency (GO:0075713)3.38520622
40DNA strand elongation involved in DNA replication (GO:0006271)3.32864908
41regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.30250006
42nucleosome disassembly (GO:0006337)3.30210361
43protein-DNA complex disassembly (GO:0032986)3.30210361
44DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.29686967
45protein localization to endoplasmic reticulum (GO:0070972)3.29194724
46negative regulation of histone methylation (GO:0031061)3.26123096
47protein localization to chromosome, centromeric region (GO:0071459)3.24713224
48mitotic sister chromatid segregation (GO:0000070)3.24613327
49nuclear-transcribed mRNA catabolic process (GO:0000956)3.24333293
50peptidyl-arginine methylation (GO:0018216)3.24099309
51peptidyl-arginine N-methylation (GO:0035246)3.24099309
52mitotic metaphase plate congression (GO:0007080)3.23891455
53negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.23755763
54positive regulation of lymphocyte apoptotic process (GO:0070230)3.22450067
55purine deoxyribonucleotide catabolic process (GO:0009155)3.22358313
56regulation of sister chromatid cohesion (GO:0007063)3.22097746
57DNA replication-independent nucleosome assembly (GO:0006336)3.22022278
58DNA replication-independent nucleosome organization (GO:0034724)3.22022278
59ribosomal large subunit biogenesis (GO:0042273)3.21997296
60chromatin remodeling at centromere (GO:0031055)3.21596731
61negative regulation of nitric oxide biosynthetic process (GO:0045019)3.20413913
62mitotic sister chromatid cohesion (GO:0007064)3.19372693
63cell migration involved in heart development (GO:0060973)3.17933461
64negative regulation of phagocytosis (GO:0050765)3.17529396
65peptidyl-arginine omega-N-methylation (GO:0035247)3.17005094
66CENP-A containing nucleosome assembly (GO:0034080)3.16176598
67telomere maintenance via semi-conservative replication (GO:0032201)3.16102906
68DNA replication initiation (GO:0006270)3.15296783
69chromatin assembly or disassembly (GO:0006333)3.14948139
70histone H2A monoubiquitination (GO:0035518)3.14672465
71sister chromatid segregation (GO:0000819)3.13840075
72negative regulation of cell size (GO:0045792)3.13641651
73DNA strand elongation (GO:0022616)3.12561673
74mRNA catabolic process (GO:0006402)3.12242774
75positive regulation of T cell apoptotic process (GO:0070234)3.09509249
76positive regulation of DNA-dependent DNA replication (GO:2000105)3.09070320
77mitotic nuclear envelope disassembly (GO:0007077)3.05860470
78DNA replication-dependent nucleosome assembly (GO:0006335)3.05588467
79DNA replication-dependent nucleosome organization (GO:0034723)3.05588467
80histone exchange (GO:0043486)3.00928371
81RNA catabolic process (GO:0006401)3.00072757
82ATP-dependent chromatin remodeling (GO:0043044)2.98729542
83response to misfolded protein (GO:0051788)2.97974078
84DNA topological change (GO:0006265)2.97468066
85nucleotide-excision repair, DNA gap filling (GO:0006297)2.92741165
86DNA replication checkpoint (GO:0000076)2.92287748
87regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.89859729
88regulation of prostaglandin secretion (GO:0032306)2.89739088
89negative regulation of myeloid cell apoptotic process (GO:0033033)2.89685909
90negative regulation of cell aging (GO:0090344)2.89590557
91mRNA stabilization (GO:0048255)2.88609826
92RNA stabilization (GO:0043489)2.88609826
93chromosome segregation (GO:0007059)2.85428382
94telomere maintenance via recombination (GO:0000722)2.85115711
95DNA deamination (GO:0045006)2.84855906
96pseudouridine synthesis (GO:0001522)2.83268674
973-UTR-mediated mRNA stabilization (GO:0070935)2.82693654
98metaphase plate congression (GO:0051310)2.82213312
99paraxial mesoderm development (GO:0048339)2.81861694
100maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.80409881
101negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.79951591
102negative regulation of DNA-templated transcription, elongation (GO:0032785)2.79951591
103iron-sulfur cluster assembly (GO:0016226)2.79884677
104metallo-sulfur cluster assembly (GO:0031163)2.79884677
105mitotic recombination (GO:0006312)2.78527248
106membrane disassembly (GO:0030397)2.78456333
107nuclear envelope disassembly (GO:0051081)2.78456333
108ribonucleoprotein complex biogenesis (GO:0022613)2.78424108
109mismatch repair (GO:0006298)2.77139000
110piRNA metabolic process (GO:0034587)2.76791112
111NIK/NF-kappaB signaling (GO:0038061)2.76479612
112T cell apoptotic process (GO:0070231)2.76398685
113angiogenesis involved in wound healing (GO:0060055)2.76263276
114protein localization to chromosome (GO:0034502)2.74642943
115tRNA modification (GO:0006400)2.73370386
116pre-miRNA processing (GO:0031054)2.72047148
117histone H2A ubiquitination (GO:0033522)2.72029424
118negative regulation of cAMP-mediated signaling (GO:0043951)2.71670427
119negative regulation of mRNA processing (GO:0050686)2.71530000
120protein insertion into membrane (GO:0051205)2.71468196
121negative regulation of tumor necrosis factor production (GO:0032720)2.71239955
122resolution of meiotic recombination intermediates (GO:0000712)2.70559833
123deoxyribonucleotide catabolic process (GO:0009264)2.68723327
124pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.67501333
125misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.66903627
126spliceosomal complex assembly (GO:0000245)2.66479011
127base-excision repair (GO:0006284)2.65590030
128histone arginine methylation (GO:0034969)2.64920838
129mature B cell differentiation involved in immune response (GO:0002313)2.64576066
130modulation by virus of host process (GO:0019054)2.62121994
131positive regulation of megakaryocyte differentiation (GO:0045654)2.61973349
132regulation of glucocorticoid metabolic process (GO:0031943)2.61643091
133positive regulation of TOR signaling (GO:0032008)2.60261036
134negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.60205879
135maturation of 5.8S rRNA (GO:0000460)2.59536767
136regulation of chromosome segregation (GO:0051983)2.59517904
137regulation of double-strand break repair via homologous recombination (GO:0010569)2.59129026
138GTP biosynthetic process (GO:0006183)2.59099136
139chromosome condensation (GO:0030261)2.57526693
140telomere maintenance via telomere lengthening (GO:0010833)2.57074601
141positive regulation of histone deacetylation (GO:0031065)2.55761874
142negative regulation of cell cycle arrest (GO:0071157)2.51982946
143mannose metabolic process (GO:0006013)2.50788184
144regulation of mammary gland epithelial cell proliferation (GO:0033599)2.48092751
145base-excision repair, AP site formation (GO:0006285)2.48050843
146negative regulation of calcium ion transport into cytosol (GO:0010523)2.47356590
147peptidyl-histidine modification (GO:0018202)2.45708874
148adhesion of symbiont to host cell (GO:0044650)2.45172007
149virion attachment to host cell (GO:0019062)2.45172007
150lipopolysaccharide metabolic process (GO:0008653)2.44724348
151ncRNA 3-end processing (GO:0043628)2.44613558
152regulation of protein sumoylation (GO:0033233)2.44267446
153regulation of mitochondrial membrane potential (GO:0051881)2.43210637
154positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.42831331
155positive regulation of icosanoid secretion (GO:0032305)2.41937133
156positive regulation of odontogenesis (GO:0042482)2.40805298
157regulation of release of cytochrome c from mitochondria (GO:0090199)2.40788990
158interleukin-1-mediated signaling pathway (GO:0070498)2.40529695
159positive regulation of protein sumoylation (GO:0033235)2.38922560
160amino sugar catabolic process (GO:0046348)2.38534272
161cytochrome complex assembly (GO:0017004)2.36720542
162lymphocyte apoptotic process (GO:0070227)2.36693520
163proline biosynthetic process (GO:0006561)2.36266690
164outflow tract septum morphogenesis (GO:0003148)2.36243616
165phosphatidylglycerol biosynthetic process (GO:0006655)2.35940338
166negative regulation of Notch signaling pathway (GO:0045746)2.35828035
167lipopolysaccharide biosynthetic process (GO:0009103)2.35003297
168purine deoxyribonucleotide metabolic process (GO:0009151)2.34512834
169positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.34117824
170vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.33376560
171opioid receptor signaling pathway (GO:0038003)2.31191298
172regulation of corticosteroid hormone secretion (GO:2000846)2.30958586
173regulation of B cell apoptotic process (GO:0002902)2.30521360
174deoxyribose phosphate catabolic process (GO:0046386)2.30310805
175guanosine-containing compound biosynthetic process (GO:1901070)2.28986565
176extracellular fibril organization (GO:0043206)2.28182992
177positive regulation of T cell mediated cytotoxicity (GO:0001916)2.26986025
178programmed necrotic cell death (GO:0097300)2.26746997
179barbed-end actin filament capping (GO:0051016)2.25411903
180organelle membrane fusion (GO:0090174)2.25399723
181cellular response to exogenous dsRNA (GO:0071360)2.25227434
182negative regulation of nitric-oxide synthase activity (GO:0051001)2.24933355
183regulation of cytokine production involved in inflammatory response (GO:1900015)2.24457557
184positive regulation of steroid hormone secretion (GO:2000833)2.24251365
185negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.24170597
186cellular response to zinc ion (GO:0071294)2.23794525
187post-embryonic morphogenesis (GO:0009886)2.22976290
188lipoxygenase pathway (GO:0019372)2.22088002
189UTP biosynthetic process (GO:0006228)2.21600882
190modulation by symbiont of host cellular process (GO:0044068)2.19389354
191negative regulation of smooth muscle cell proliferation (GO:0048662)2.18711472
192leukocyte apoptotic process (GO:0071887)2.18557196
193negative regulation of B cell apoptotic process (GO:0002903)2.18153429
194adhesion of symbiont to host (GO:0044406)2.17722463

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.39380530
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.49176645
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.30380647
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.10928598
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.89853068
6TP63_19390658_ChIP-ChIP_HaCaT_Human3.63672708
7LXR_22292898_ChIP-Seq_THP-1_Human2.97002179
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.93293378
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.91404832
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.87661559
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.85098716
12MYC_22102868_ChIP-Seq_BL_Human2.80256686
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.70556140
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.59535377
15ELK3_25401928_ChIP-Seq_HUVEC_Human2.51500186
16ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.50366042
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.34768116
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.34194573
19XRN2_22483619_ChIP-Seq_HELA_Human2.33384058
20TET1_21451524_ChIP-Seq_MESCs_Mouse2.32204414
21P68_20966046_ChIP-Seq_HELA_Human2.17445776
22RBPJ_22232070_ChIP-Seq_NCS_Mouse2.14953673
23ELF1_20517297_ChIP-Seq_JURKAT_Human2.13767897
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.09818502
25BCL6_27268052_Chip-Seq_Bcells_Human2.09487843
26* E2F1_21310950_ChIP-Seq_MCF-7_Human2.05876160
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.04256453
28CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.97322151
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.97215239
30HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.96307700
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.94281838
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.92239407
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.92073079
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.90877451
35TTF2_22483619_ChIP-Seq_HELA_Human1.88826920
36RACK7_27058665_Chip-Seq_MCF-7_Human1.88251167
37IRF8_22096565_ChIP-ChIP_GC-B_Human1.86665944
38BCOR_27268052_Chip-Seq_Bcells_Human1.85951528
39SA1_27219007_Chip-Seq_ERYTHROID_Human1.85288187
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.84294210
41CIITA_25753668_ChIP-Seq_RAJI_Human1.83944042
42SCL_19346495_ChIP-Seq_HPC-7_Human1.72974374
43VDR_21846776_ChIP-Seq_THP-1_Human1.69916950
44DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.68916281
45AR_21909140_ChIP-Seq_LNCAP_Human1.68598213
46TP53_22127205_ChIP-Seq_IMR90_Human1.68291407
47E2F1_20622854_ChIP-Seq_HELA_Human1.67799317
48CTCF_27219007_Chip-Seq_ERYTHROID_Human1.67085311
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.66580334
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.66204317
51ETS1_20019798_ChIP-Seq_JURKAT_Human1.65484668
52NELFA_20434984_ChIP-Seq_ESCs_Mouse1.65232755
53CTCF_26484167_Chip-Seq_Bcells_Mouse1.63115037
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62911708
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.62384890
56* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60142413
57VDR_24763502_ChIP-Seq_THP-1_Human1.59685655
58EST1_17652178_ChIP-ChIP_JURKAT_Human1.59126314
59PHF8_20622854_ChIP-Seq_HELA_Human1.58684866
60CTCF_20526341_ChIP-Seq_ESCs_Human1.57968651
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.53680437
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.53385920
63SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.52887872
64MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.51805935
65* MYC_18940864_ChIP-ChIP_HL60_Human1.51654278
66SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.50908176
67GABP_19822575_ChIP-Seq_HepG2_Human1.48090884
68EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.47586133
69YY1_22570637_ChIP-Seq_MALME-3M_Human1.45621958
70E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.45314451
71SOX2_18555785_ChIP-Seq_MESCs_Mouse1.45035471
72CTCF_27219007_Chip-Seq_Bcells_Human1.44813517
73TCF7_22412390_ChIP-Seq_EML_Mouse1.43991078
74P300_27268052_Chip-Seq_Bcells_Human1.43636360
75GABP_17652178_ChIP-ChIP_JURKAT_Human1.43521690
76JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.43249799
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.42919510
78CTCF_21964334_ChIP-Seq_BJAB-B_Human1.42075479
79CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41244607
80SRY_22984422_ChIP-ChIP_TESTIS_Rat1.39922000
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.39137231
82ZNF263_19887448_ChIP-Seq_K562_Human1.38808837
83* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37818652
84SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.37719269
85HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.36051705
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.35639296
87TP63_22573176_ChIP-Seq_HFKS_Human1.35454051
88POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.34823214
89FOXP1_21924763_ChIP-Seq_HESCs_Human1.33962184
90TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33340699
91* NANOG_21062744_ChIP-ChIP_HESCs_Human1.33248789
92SA1_27219007_Chip-Seq_Bcells_Human1.33155908
93CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.33096270
94UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33052138
95FOXP3_21729870_ChIP-Seq_TREG_Human1.32628917
96KDM5A_27292631_Chip-Seq_BREAST_Human1.32386027
97KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.31517735
98STAT1_20625510_ChIP-Seq_HELA_Human1.31393996
99MAF_26560356_Chip-Seq_TH1_Human1.31229463
100KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.30984228
101MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.30144463
102SMC4_20622854_ChIP-Seq_HELA_Human1.29491327
103HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27701888
104NANOG_18555785_ChIP-Seq_MESCs_Mouse1.27168246
105CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.25197918
106TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25084030
107VDR_23849224_ChIP-Seq_CD4+_Human1.24829973
108DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24250076
109GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23907567
110RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.23395222
111RUNX1_22412390_ChIP-Seq_EML_Mouse1.22925936
112PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21544826
113SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20151124
114SMC3_22415368_ChIP-Seq_MEFs_Mouse1.19160528
115E2F1_18555785_ChIP-Seq_MESCs_Mouse1.18908067
116LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.17269224
117POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15971289
118* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15803423
119RARB_24833708_ChIP-Seq_LIVER_Mouse1.15482753
120ERA_21632823_ChIP-Seq_H3396_Human1.15431675
121SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.14697145
122ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13732541
123RAC3_21632823_ChIP-Seq_H3396_Human1.11842287
124TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10805327
125GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10573781
126NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10317626
127* CREB1_26743006_Chip-Seq_LNCaP_Human1.10152463
128SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.09335560
129ETS1_21867929_ChIP-Seq_TH2_Mouse1.08954075
130SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08524109
131SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08360864
132MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.07945890
133CREB1_15753290_ChIP-ChIP_HEK293T_Human1.07849555
134KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07572787
135P63_26484246_Chip-Seq_KERATINOCYTES_Human1.07168571
136GATA1_19941827_ChIP-Seq_MEL_Mouse1.07044114
137UTX_26944678_Chip-Seq_JUKART_Human1.06884652
138KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06583105
139RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06464160
140* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06454389
141PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05856796
142THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05808139
143STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04284321
144* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04254239
145ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03465458
146SPI1_20517297_ChIP-Seq_HL60_Human1.03166505
147* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02368218
148* DCP1A_22483619_ChIP-Seq_HELA_Human1.02307894
149CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01970364
150YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01359558
151RNF2_27304074_Chip-Seq_NSC_Mouse0.95849795
152DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95446412
153YY1_21170310_ChIP-Seq_MESCs_Mouse0.95370266
154* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.93296386
155HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92999765
156POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92096657
157ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91261633
158TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90769990
159POU5F1_16518401_ChIP-PET_MESCs_Mouse0.88666620
160SOX2_16153702_ChIP-ChIP_HESCs_Human0.87684298
161SALL1_21062744_ChIP-ChIP_HESCs_Human0.87211893
162CBX2_27304074_Chip-Seq_ESCs_Mouse0.85789165
163KDM2B_26808549_Chip-Seq_DND41_Human0.84458455
164STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83288268
165SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.83178094
166KDM2B_26808549_Chip-Seq_JURKAT_Human0.82519350
167SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.81829993
168KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.77602981
169MAF_26560356_Chip-Seq_TH2_Human0.76524479
170IRF1_19129219_ChIP-ChIP_H3396_Human0.76436411
171CTCF_21964334_Chip-Seq_Bcells_Human0.74805060
172ZFP281_18757296_ChIP-ChIP_E14_Mouse0.74488066
173NANOG_16153702_ChIP-ChIP_HESCs_Human0.74427880
174PKCTHETA_26484144_Chip-Seq_BREAST_Human0.74330328
175CTCF_18555785_ChIP-Seq_MESCs_Mouse0.74310976

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.30326243
2MP0003693_abnormal_embryo_hatching3.06845960
3MP0003111_abnormal_nucleus_morphology3.04425153
4MP0010094_abnormal_chromosome_stability3.01019625
5MP0002102_abnormal_ear_morphology2.82275945
6MP0003077_abnormal_cell_cycle2.82070210
7MP0006292_abnormal_olfactory_placode2.81982539
8MP0005058_abnormal_lysosome_morphology2.70394214
9MP0010030_abnormal_orbit_morphology2.66940450
10MP0004510_myositis2.63755679
11MP0008057_abnormal_DNA_replication2.55181775
12MP0003279_aneurysm2.43561045
13MP0004858_abnormal_nervous_system2.43378523
14MP0006054_spinal_hemorrhage2.39537712
15MP0004957_abnormal_blastocyst_morpholog2.35361073
16MP0008438_abnormal_cutaneous_collagen2.34179177
17MP0002249_abnormal_larynx_morphology2.29454708
18MP0005623_abnormal_meninges_morphology2.28823538
19MP0003315_abnormal_perineum_morphology2.15749418
20MP0008058_abnormal_DNA_repair2.12804176
21MP0002938_white_spotting2.10019322
22MP0000465_gastrointestinal_hemorrhage2.09935174
23MP0005464_abnormal_platelet_physiology2.09363455
24MP0000013_abnormal_adipose_tissue2.08730182
25MP0000566_synostosis2.06566712
26MP0002163_abnormal_gland_morphology2.01604358
27MP0009840_abnormal_foam_cell1.98676652
28MP0000003_abnormal_adipose_tissue1.96934884
29MP0005670_abnormal_white_adipose1.96928679
30MP0009053_abnormal_anal_canal1.93057434
31MP0002396_abnormal_hematopoietic_system1.90586185
32MP0003123_paternal_imprinting1.90284240
33MP0008007_abnormal_cellular_replicative1.88945401
34MP0009333_abnormal_splenocyte_physiolog1.86628268
35MP0003385_abnormal_body_wall1.85629772
36MP0000681_abnormal_thyroid_gland1.85166101
37MP0000049_abnormal_middle_ear1.82005266
38MP0005360_urolithiasis1.77926877
39MP0009250_abnormal_appendicular_skeleto1.77107452
40MP0003937_abnormal_limbs/digits/tail_de1.76460110
41MP0002653_abnormal_ependyma_morphology1.72522683
42MP0008789_abnormal_olfactory_epithelium1.66651264
43MP0010368_abnormal_lymphatic_system1.65777940
44MP0001873_stomach_inflammation1.64472728
45MP0001661_extended_life_span1.64171530
46MP0002234_abnormal_pharynx_morphology1.62024580
47MP0002148_abnormal_hypersensitivity_rea1.60128687
48MP0009379_abnormal_foot_pigmentation1.55359568
49MP0008932_abnormal_embryonic_tissue1.53620997
50MP0009278_abnormal_bone_marrow1.53484281
51MP0000490_abnormal_crypts_of1.51643785
52MP0002210_abnormal_sex_determination1.49595130
53MP0000350_abnormal_cell_proliferation1.48373734
54MP0002085_abnormal_embryonic_tissue1.48197580
55MP0000516_abnormal_urinary_system1.47819976
56MP0005367_renal/urinary_system_phenotyp1.47819976
57MP0004808_abnormal_hematopoietic_stem1.47066402
58MP0003646_muscle_fatigue1.46448250
59MP0003121_genomic_imprinting1.44149722
60MP0003718_maternal_effect1.44004172
61MP0000343_altered_response_to1.42728279
62MP0005375_adipose_tissue_phenotype1.42453705
63MP0003567_abnormal_fetal_cardiomyocyte1.42379083
64MP0003938_abnormal_ear_development1.40907690
65MP0008995_early_reproductive_senescence1.39399999
66MP0002932_abnormal_joint_morphology1.38829483
67MP0008877_abnormal_DNA_methylation1.38763709
68MP0000538_abnormal_urinary_bladder1.38430742
69MP0005410_abnormal_fertilization1.36535650
70MP0005646_abnormal_pituitary_gland1.36462073
71MP0001929_abnormal_gametogenesis1.36355266
72MP0003890_abnormal_embryonic-extraembry1.35997311
73MP0005174_abnormal_tail_pigmentation1.34642587
74MP0003942_abnormal_urinary_system1.34639889
75MP0002084_abnormal_developmental_patter1.33951755
76MP0001293_anophthalmia1.32506250
77MP0003755_abnormal_palate_morphology1.32233921
78MP0003786_premature_aging1.30369270
79MP0001119_abnormal_female_reproductive1.30138058
80MP0006036_abnormal_mitochondrial_physio1.29326857
81MP0000733_abnormal_muscle_development1.29320499
82MP0001958_emphysema1.27895489
83MP0004130_abnormal_muscle_cell1.27039381
84MP0002116_abnormal_craniofacial_bone1.26165298
85MP0002233_abnormal_nose_morphology1.25772757
86MP0003705_abnormal_hypodermis_morpholog1.25444354
87MP0000653_abnormal_sex_gland1.25407643
88MP0000537_abnormal_urethra_morphology1.23565355
89MP0005397_hematopoietic_system_phenotyp1.22343394
90MP0001545_abnormal_hematopoietic_system1.22343394
91MP0001730_embryonic_growth_arrest1.21997895
92MP0001145_abnormal_male_reproductive1.21980263
93MP0005257_abnormal_intraocular_pressure1.21243903
94MP0005187_abnormal_penis_morphology1.20950564
95MP0005025_abnormal_response_to1.20703283
96MP0001697_abnormal_embryo_size1.20514577
97MP0002282_abnormal_trachea_morphology1.19774210
98MP0003935_abnormal_craniofacial_develop1.19674649
99MP0002254_reproductive_system_inflammat1.19104008
100MP0001835_abnormal_antigen_presentation1.16890955
101MP0005380_embryogenesis_phenotype1.16787135
102MP0001672_abnormal_embryogenesis/_devel1.16787135
103MP0003119_abnormal_digestive_system1.13730872
104MP0001664_abnormal_digestion1.13362754
105MP0003861_abnormal_nervous_system1.12740124
106MP0002177_abnormal_outer_ear1.12063345
107MP0004197_abnormal_fetal_growth/weight/1.11874933
108MP0005501_abnormal_skin_physiology1.11704028
109MP0009384_cardiac_valve_regurgitation1.11021580
110MP0003763_abnormal_thymus_physiology1.10868109
111MP0001849_ear_inflammation1.10336624
112MP0005394_taste/olfaction_phenotype1.09380832
113MP0005499_abnormal_olfactory_system1.09380832
114MP0002114_abnormal_axial_skeleton1.08997481
115MP0005451_abnormal_body_composition1.08714826
116MP0003436_decreased_susceptibility_to1.07888021
117MP0000858_altered_metastatic_potential1.07013676
118MP0005000_abnormal_immune_tolerance1.06420967
119MP0002723_abnormal_immune_serum1.05898250
120MP0000015_abnormal_ear_pigmentation1.05031899
121MP0002420_abnormal_adaptive_immunity1.04769465
122MP0001819_abnormal_immune_cell1.02336294
123MP0002019_abnormal_tumor_incidence1.02083754
124MP0000428_abnormal_craniofacial_morphol1.01706078
125MP0003186_abnormal_redox_activity1.01015832
126MP0000631_abnormal_neuroendocrine_gland1.00906601
127MP0005503_abnormal_tendon_morphology1.00574645
128MP0005390_skeleton_phenotype1.00524915
129MP0000432_abnormal_head_morphology1.00464486
130MP0005379_endocrine/exocrine_gland_phen1.00249063
131MP0005666_abnormal_adipose_tissue0.99733154
132MP0005083_abnormal_biliary_tract0.99401642
133MP0003699_abnormal_female_reproductive0.98743291
134MP0005076_abnormal_cell_differentiation0.97915820
135MP0005671_abnormal_response_to0.97845068
136MP0002080_prenatal_lethality0.97700442
137MP0001533_abnormal_skeleton_physiology0.97683767
138MP0000678_abnormal_parathyroid_gland0.97453211
139MP0002837_dystrophic_cardiac_calcinosis0.97254631
140MP0002419_abnormal_innate_immunity0.97073096
141MP0002109_abnormal_limb_morphology0.96858334
142MP0000703_abnormal_thymus_morphology0.96557782
143MP0003115_abnormal_respiratory_system0.96042810
144MP0002088_abnormal_embryonic_growth/wei0.95988132
145MP0003984_embryonic_growth_retardation0.95755039
146MP0000685_abnormal_immune_system0.95182103
147MP0002095_abnormal_skin_pigmentation0.95168047
148MP0004185_abnormal_adipocyte_glucose0.94783182
149MP0002697_abnormal_eye_size0.94566223
150MP0000313_abnormal_cell_death0.94233364
151MP0001790_abnormal_immune_system0.93402041
152MP0005387_immune_system_phenotype0.93402041
153MP0003698_abnormal_male_reproductive0.92981204
154MP0002111_abnormal_tail_morphology0.92749526
155MP0000750_abnormal_muscle_regeneration0.92663882
156MP0001286_abnormal_eye_development0.92033888
157MP0001879_abnormal_lymphatic_vessel0.91449886
158MP0001915_intracranial_hemorrhage0.90517444
159MP0002452_abnormal_antigen_presenting0.89794024
160MP0002092_abnormal_eye_morphology0.89753017
161MP0001348_abnormal_lacrimal_gland0.88653427
162MP0001845_abnormal_inflammatory_respons0.88093761
163MP0003172_abnormal_lysosome_physiology0.87788844
164MP0005508_abnormal_skeleton_morphology0.87490284
165MP0003075_altered_response_to0.87341673
166MP0006082_CNS_inflammation0.86952383
167MP0000579_abnormal_nail_morphology0.86803444
168MP0002161_abnormal_fertility/fecundity0.86275250
169MP0005248_abnormal_Harderian_gland0.85809269
170MP0009643_abnormal_urine_homeostasis0.84070851
171MP0010155_abnormal_intestine_physiology0.82561355
172MP0001905_abnormal_dopamine_level0.82038741
173MP0002160_abnormal_reproductive_system0.81832925
174MP0000759_abnormal_skeletal_muscle0.80416821
175MP0008775_abnormal_heart_ventricle0.80060115
176MP0009764_decreased_sensitivity_to0.79844160
177MP0004947_skin_inflammation0.78748462
178MP0002998_abnormal_bone_remodeling0.77810952
179MP0008469_abnormal_protein_level0.77241440
180MP0002089_abnormal_postnatal_growth/wei0.77000701
181MP0002098_abnormal_vibrissa_morphology0.74917263
182MP0005595_abnormal_vascular_smooth0.74585472
183MP0001800_abnormal_humoral_immune0.73902983
184MP0003453_abnormal_keratinocyte_physiol0.73724502
185MP0002127_abnormal_cardiovascular_syste0.73641927
186MP0002877_abnormal_melanocyte_morpholog0.72047139

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.15964518
2Short 4th metacarpal (HP:0010044)4.11944759
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.11944759
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.09919085
5Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.05912222
6Decreased activity of mitochondrial respiratory chain (HP:0008972)4.05912222
7Abnormality of cells of the erythroid lineage (HP:0012130)3.84711395
8Hyperthyroidism (HP:0000836)3.77997601
9Chromsome breakage (HP:0040012)3.77931117
10Abnormal number of erythroid precursors (HP:0012131)3.63478768
11Petechiae (HP:0000967)3.58103847
12Facial hemangioma (HP:0000329)3.55219061
13Patellar aplasia (HP:0006443)3.50255397
14Aplasia/Hypoplasia of the patella (HP:0006498)3.46444644
15Abnormality of glycolipid metabolism (HP:0010969)3.38635048
16Abnormality of liposaccharide metabolism (HP:0010968)3.38635048
17Abnormality of glycosphingolipid metabolism (HP:0004343)3.38635048
18Purpura (HP:0000979)3.31902808
19Abnormality of the 4th metacarpal (HP:0010012)3.24072663
20Increased muscle lipid content (HP:0009058)3.15737227
21Meckel diverticulum (HP:0002245)3.08476158
22Abnormality of the ileum (HP:0001549)3.02822667
23Increased neuronal autofluorescent lipopigment (HP:0002074)2.98401185
24Abnormality of the fingertips (HP:0001211)2.89670382
25Aplasia/Hypoplasia of the uvula (HP:0010293)2.86166446
26Achilles tendon contracture (HP:0001771)2.83445789
27Premature skin wrinkling (HP:0100678)2.79169927
28Nonimmune hydrops fetalis (HP:0001790)2.76905398
29Increased intramyocellular lipid droplets (HP:0012240)2.75827578
30Abnormality of the phalanges of the hallux (HP:0010057)2.75625283
31Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.74439336
32Medulloblastoma (HP:0002885)2.73734595
33Renal Fanconi syndrome (HP:0001994)2.67807547
34Aplastic anemia (HP:0001915)2.67776024
35Renal duplication (HP:0000075)2.64494367
36Pallor (HP:0000980)2.63348646
37Obstructive lung disease (HP:0006536)2.61751477
38Chronic obstructive pulmonary disease (HP:0006510)2.61751477
39Abnormality of the preputium (HP:0100587)2.61346433
40Increased cerebral lipofuscin (HP:0011813)2.60515022
41Premature rupture of membranes (HP:0001788)2.57919401
42Broad distal phalanx of finger (HP:0009836)2.56805977
43Autoimmune thrombocytopenia (HP:0001973)2.54692421
44Prolonged bleeding time (HP:0003010)2.53445735
45Abnormality of the carotid arteries (HP:0005344)2.50859685
46Joint stiffness (HP:0001387)2.50691598
47Abnormality of the columella (HP:0009929)2.50043630
48Rib fusion (HP:0000902)2.49223946
49Myopathic facies (HP:0002058)2.45844303
50Colon cancer (HP:0003003)2.45248447
51Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.44536931
52Pendular nystagmus (HP:0012043)2.41602305
53Hypertensive crisis (HP:0100735)2.41011163
54Dysostosis multiplex (HP:0000943)2.40336884
55Rectal prolapse (HP:0002035)2.40279521
56Myelodysplasia (HP:0002863)2.39766225
57Round ear (HP:0100830)2.39666314
58Stridor (HP:0010307)2.38974376
59Abnormality of the Achilles tendon (HP:0005109)2.37962658
60Abnormality of the intervertebral disk (HP:0005108)2.36837809
61Breast hypoplasia (HP:0003187)2.36248168
62Male infertility (HP:0003251)2.35978578
63Ileus (HP:0002595)2.35509325
64Ectopic kidney (HP:0000086)2.34456075
65Bulbar palsy (HP:0001283)2.33106637
66Cerebellar dysplasia (HP:0007033)2.32945915
67Elbow flexion contracture (HP:0002987)2.31885454
68Atresia of the external auditory canal (HP:0000413)2.30138419
69Abnormal number of incisors (HP:0011064)2.29837891
70Triphalangeal thumb (HP:0001199)2.29453129
71Clubbing of toes (HP:0100760)2.28936581
72Short thumb (HP:0009778)2.27095131
73Vertebral compression fractures (HP:0002953)2.26375874
74Abnormality of the distal phalanges of the toes (HP:0010182)2.24758636
75Hyperacusis (HP:0010780)2.24332912
76Truncus arteriosus (HP:0001660)2.22082330
77Cutaneous melanoma (HP:0012056)2.20653440
78Abnormality of the diencephalon (HP:0010662)2.19619767
79Birth length less than 3rd percentile (HP:0003561)2.17360945
80Oral leukoplakia (HP:0002745)2.16538334
81Increased serum ferritin (HP:0003281)2.16333869
82Concave nail (HP:0001598)2.15985987
83Shawl scrotum (HP:0000049)2.14389797
84Long toe (HP:0010511)2.13883627
85Abnormality of chromosome stability (HP:0003220)2.13744870
86Lipid accumulation in hepatocytes (HP:0006561)2.13677208
87Abnormality of the parietal bone (HP:0002696)2.12606665
88Selective tooth agenesis (HP:0001592)2.12539859
89Tracheoesophageal fistula (HP:0002575)2.10672207
90Abnormal umbilical cord blood vessels (HP:0011403)2.09590061
91Single umbilical artery (HP:0001195)2.09590061
92Abnormality of the fetal cardiovascular system (HP:0010948)2.09590061
93Muscle fiber atrophy (HP:0100295)2.07556996
94Absent thumb (HP:0009777)2.07344138
95Abnormality of the tricuspid valve (HP:0001702)2.07308184
96Generalized amyotrophy (HP:0003700)2.07174611
97Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.06824455
98Nephroblastoma (Wilms tumor) (HP:0002667)2.06754411
99Aplasia/Hypoplasia of the sacrum (HP:0008517)2.06348772
100Renovascular hypertension (HP:0100817)2.05639107
101Granulocytopenia (HP:0001913)2.05518883
102Spina bifida occulta (HP:0003298)2.04818771
103Increased nuchal translucency (HP:0010880)2.04080674
104Short clavicles (HP:0000894)2.04058894
105Macrocytic anemia (HP:0001972)2.03647276
106Flat capital femoral epiphysis (HP:0003370)2.03053048
107Thrombocytosis (HP:0001894)2.02781537
108Poikiloderma (HP:0001029)2.01990792
109Visual hallucinations (HP:0002367)2.00270159
110Abnormality of T cell physiology (HP:0011840)1.99940167
111Lymphangioma (HP:0100764)1.99171076
112Abnormality of DNA repair (HP:0003254)1.98576704
113Abnormality of mucopolysaccharide metabolism (HP:0011020)1.98501154
114Abnormality of polysaccharide metabolism (HP:0011012)1.98501154
115Abnormality of glycosaminoglycan metabolism (HP:0004371)1.98501154
116Megalocornea (HP:0000485)1.98361039
117Asymmetry of the thorax (HP:0001555)1.97849061
118Small intestinal stenosis (HP:0012848)1.94647046
119Duodenal stenosis (HP:0100867)1.94647046
120Embryonal renal neoplasm (HP:0011794)1.94209712
121Prolonged neonatal jaundice (HP:0006579)1.93886246
122Midline defect of the nose (HP:0004122)1.92650235
123Elfin facies (HP:0004428)1.91280068
124Exertional dyspnea (HP:0002875)1.90698129
125Flat cornea (HP:0007720)1.89814189
126Fragile skin (HP:0001030)1.89674910
127Type II lissencephaly (HP:0007260)1.89628969
128Distal lower limb muscle weakness (HP:0009053)1.89501945
129Elevated erythrocyte sedimentation rate (HP:0003565)1.89250733
130Autoimmune hemolytic anemia (HP:0001890)1.88786600
131Opisthotonus (HP:0002179)1.88530127
132Abnormal delayed hypersensitivity skin test (HP:0002963)1.86767429
133Mesangial abnormality (HP:0001966)1.86481252
134Epistaxis (HP:0000421)1.86468035
135Aplasia/Hypoplasia of the clavicles (HP:0006710)1.85954101
136Increased IgM level (HP:0003496)1.84181767
137Type 2 muscle fiber atrophy (HP:0003554)1.83309644
138Germ cell neoplasia (HP:0100728)1.82897807
139Embryonal neoplasm (HP:0002898)1.82742012
140Shallow orbits (HP:0000586)1.82406368
141Recurrent abscess formation (HP:0002722)1.81454757
142Abnormality of iron homeostasis (HP:0011031)1.80942705
143Hepatocellular necrosis (HP:0001404)1.80928681
144Abnormality of the labia minora (HP:0012880)1.80309591
145High anterior hairline (HP:0009890)1.79496931
146Abnormality of the distal phalanx of the thumb (HP:0009617)1.79258879
147Abnormality of the umbilical cord (HP:0010881)1.78844943
148Capillary hemangiomas (HP:0005306)1.78378913
149Stomatitis (HP:0010280)1.78325839
150Menorrhagia (HP:0000132)1.78239663
151Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.77451029
152Insulin-resistant diabetes mellitus (HP:0000831)1.76938639
153Aplasia/Hypoplasia of the sternum (HP:0006714)1.76901816
154Spinal rigidity (HP:0003306)1.76538378
155Thick lower lip vermilion (HP:0000179)1.75467861
156Pulmonary artery stenosis (HP:0004415)1.75327116
157Sparse scalp hair (HP:0002209)1.74712163
158Agammaglobulinemia (HP:0004432)1.74180005
159Overriding aorta (HP:0002623)1.74178355
160Abnormality of the aortic arch (HP:0012303)1.73786035
161Microglossia (HP:0000171)1.72266622
162Arteriovenous malformation (HP:0100026)1.70229129
163Short phalanx of the thumb (HP:0009660)1.69871724
164Cerebral palsy (HP:0100021)1.69743272
165Congenital diaphragmatic hernia (HP:0000776)1.69534258
166Patellar dislocation (HP:0002999)1.69106478
167Asymmetric septal hypertrophy (HP:0001670)1.68946820
168Fibular aplasia (HP:0002990)1.68916321
169Mitochondrial inheritance (HP:0001427)1.68688526
170Glucose intolerance (HP:0000833)1.68524306
171Sloping forehead (HP:0000340)1.67030547
172Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.66814676
173Acanthosis nigricans (HP:0000956)1.65825708
174Unilateral renal agenesis (HP:0000122)1.65164372
175Squamous cell carcinoma (HP:0002860)1.65162544
176Redundant skin (HP:0001582)1.64165346
177Insulin resistance (HP:0000855)1.64127260
178Increased density of long bones (HP:0006392)1.63939589
179Basal cell carcinoma (HP:0002671)1.63504670
180Genu recurvatum (HP:0002816)1.63142254
181Increased mean platelet volume (HP:0011877)1.62837832
182Abnormality of subcutaneous fat tissue (HP:0001001)1.62473293
183Abnormal lung lobation (HP:0002101)1.62173994
184Hypertriglyceridemia (HP:0002155)1.62161407
185Sacral dimple (HP:0000960)1.62125244
186Broad thumb (HP:0011304)1.61912371
187Ragged-red muscle fibers (HP:0003200)1.60687787
188Sparse lateral eyebrow (HP:0005338)1.59919777
189Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.59547306
190Oligodactyly (HP:0012165)1.59508318
191Short middle phalanx of the 5th finger (HP:0004220)1.59335281
192Neoplasm of striated muscle (HP:0009728)1.58938537
193Aplasia/Hypoplasia of the breasts (HP:0010311)1.58436015
194Rhabdomyosarcoma (HP:0002859)1.58053133
195Protrusio acetabuli (HP:0003179)1.57359601

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.33921170
2EEF2K4.33314241
3LATS23.79940066
4CDC73.40871420
5TESK23.31279731
6IRAK32.94493638
7MAP3K62.83580125
8KDR2.68515818
9DYRK22.65261792
10CDK82.58040146
11NEK22.47362710
12MKNK22.46520004
13TESK12.35738005
14SRPK12.15340920
15MAP3K102.08249162
16MAPK132.02819079
17PINK12.02189266
18FRK2.00470263
19BUB11.98106717
20MKNK11.97344263
21CDK71.92057462
22ERN11.85574977
23STK38L1.81543254
24MAP2K31.76614761
25RPS6KB21.68901220
26MARK11.67978787
27CHEK21.63571454
28ARAF1.62402816
29VRK21.59613129
30TAOK11.57321200
31PLK41.55027211
32TGFBR11.52154894
33WEE11.51717576
34DYRK31.51619124
35PKN21.39249854
36TNK21.39198141
37IKBKB1.36407198
38MUSK1.36323685
39SIK11.32316403
40PLK11.31667712
41TLK11.28273869
42STK31.26033314
43TTK1.25978755
44GRK61.25115684
45MAP2K21.24991882
46TBK11.20021171
47VRK11.18967568
48NME21.16009446
49MYLK1.14892582
50AURKA1.12205534
51PRPF4B1.09308016
52ERBB41.09249206
53LIMK11.08129067
54ZAK1.05582782
55MAP4K11.03762732
56AURKB1.03171246
57PRKD21.02096334
58PDPK11.01980314
59ATR1.01773480
60MAP2K61.01521942
61CDK41.01266233
62CDK121.00624202
63CDK90.99636929
64TRIB30.98580775
65ADRBK10.98434948
66TNIK0.98087154
67SMG10.96747905
68BCKDK0.95877614
69ICK0.94484661
70TTN0.94147261
71ILK0.93750481
72PRKD30.92797039
73PRKG20.87962281
74CHEK10.87354206
75RPS6KA40.87324529
76ATM0.83878647
77HIPK20.82087549
78RPS6KA50.80431478
79DYRK1B0.79976351
80EPHB20.78236035
81MAP2K70.76721855
82DAPK30.75137394
83PIM10.74623854
84MAP3K10.74069066
85FLT30.74056598
86TAOK30.73775569
87STK40.73710231
88BRSK20.73022455
89MAP3K30.72901133
90CDC42BPA0.71457090
91KIT0.70507133
92CSNK1G30.69929544
93ABL20.69430495
94CSNK1G10.69340224
95BRAF0.68107157
96EPHA20.67893831
97* CDK20.66194941
98MATK0.65705139
99ZAP700.64940040
100CDK190.63645328
101PDK10.61266515
102CSF1R0.59768953
103PASK0.59370419
104SIK20.58946393
105CAMKK20.58477440
106MARK30.58453148
107RPS6KC10.58293306
108RPS6KL10.58293306
109MAP3K80.57958711
110MAPKAPK30.56336496
111MARK20.56314905
112RPS6KA60.55760385
113JAK30.55448549
114STK380.54926881
115TGFBR20.53785695
116MAP2K10.52464751
117MAPK120.52421223
118RPS6KA20.51832664
119RAF10.51348737
120MAP4K20.51280308
121IRAK20.51239523
122LRRK20.50848551
123* CDK10.50043574
124UHMK10.49950308
125CSNK1G20.49557018
126CSNK1A1L0.49501376
127MTOR0.48959955
128TXK0.48083530
129PIK3CG0.47927033
130MAPK110.46421271
131PTK20.46056872
132PIM20.45562597
133MOS0.45410861
134SIK30.45054210
135PRKD10.44802094
136RPS6KA10.44656272
137LMTK20.44593543
138AKT20.43479281
139PAK10.42334205
140ACVR1B0.42120960
141DDR20.41918488
142TAOK20.41799688
143SYK0.41581322
144BRSK10.40170587
145HCK0.39607516
146CDK60.39159862
147CHUK0.38399085
148CSNK2A20.38368259
149PKN10.38256614
150PRKCI0.38039349
151CSNK2A10.37768153
152YES10.37759366
153BTK0.37405703
154TYRO30.36988567
155ERBB30.36245490
156PAK40.36204716
157PTK60.35633721
158MAP3K110.35397011
159BMX0.35204870
160ADRBK20.35068245
161MAPK40.33591069

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.99359362
2DNA replication_Homo sapiens_hsa030303.93695466
3Mismatch repair_Homo sapiens_hsa034303.43793832
4Cell cycle_Homo sapiens_hsa041103.04826229
5Other glycan degradation_Homo sapiens_hsa005112.99715103
6Homologous recombination_Homo sapiens_hsa034402.94418338
7Base excision repair_Homo sapiens_hsa034102.93032408
8Spliceosome_Homo sapiens_hsa030402.83228549
9Fanconi anemia pathway_Homo sapiens_hsa034602.73793667
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.70414511
11Nucleotide excision repair_Homo sapiens_hsa034202.56213832
12RNA polymerase_Homo sapiens_hsa030202.46425668
13RNA transport_Homo sapiens_hsa030132.39434096
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.18908173
15Basal transcription factors_Homo sapiens_hsa030222.18399493
16RNA degradation_Homo sapiens_hsa030182.11130670
17mRNA surveillance pathway_Homo sapiens_hsa030152.06197295
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.02610614
19Lysosome_Homo sapiens_hsa041421.96677905
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.95308869
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.93268720
22Pyrimidine metabolism_Homo sapiens_hsa002401.78537441
23One carbon pool by folate_Homo sapiens_hsa006701.75981593
24Non-homologous end-joining_Homo sapiens_hsa034501.71233077
25Basal cell carcinoma_Homo sapiens_hsa052171.70724074
26p53 signaling pathway_Homo sapiens_hsa041151.65443260
27Sulfur metabolism_Homo sapiens_hsa009201.59370852
28Vitamin B6 metabolism_Homo sapiens_hsa007501.49507891
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.46205750
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.43523217
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42190376
32Hedgehog signaling pathway_Homo sapiens_hsa043401.40220226
33Colorectal cancer_Homo sapiens_hsa052101.33128600
34Transcriptional misregulation in cancer_Homo sapiens_hsa052021.31590637
35Chronic myeloid leukemia_Homo sapiens_hsa052201.30931822
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.30597183
37MicroRNAs in cancer_Homo sapiens_hsa052061.26965918
38Notch signaling pathway_Homo sapiens_hsa043301.26251154
39Platelet activation_Homo sapiens_hsa046111.23985607
40TGF-beta signaling pathway_Homo sapiens_hsa043501.22902440
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.18134530
42Hippo signaling pathway_Homo sapiens_hsa043901.17462662
43Glutathione metabolism_Homo sapiens_hsa004801.17193407
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.14821091
45Herpes simplex infection_Homo sapiens_hsa051681.13384539
46Pancreatic cancer_Homo sapiens_hsa052121.13362723
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.13348149
48Oxidative phosphorylation_Homo sapiens_hsa001901.06734456
49Allograft rejection_Homo sapiens_hsa053301.05269138
50HTLV-I infection_Homo sapiens_hsa051661.03118446
51Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.02986866
52Small cell lung cancer_Homo sapiens_hsa052221.02490897
53Endometrial cancer_Homo sapiens_hsa052131.02191712
54Toll-like receptor signaling pathway_Homo sapiens_hsa046201.01765255
55Bladder cancer_Homo sapiens_hsa052191.01747465
56Osteoclast differentiation_Homo sapiens_hsa043801.00925095
57TNF signaling pathway_Homo sapiens_hsa046681.00855629
58Thyroid cancer_Homo sapiens_hsa052161.00719587
59Graft-versus-host disease_Homo sapiens_hsa053321.00212019
60Non-small cell lung cancer_Homo sapiens_hsa052230.98481166
61Acute myeloid leukemia_Homo sapiens_hsa052210.98118198
62Fructose and mannose metabolism_Homo sapiens_hsa000510.96686719
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95552386
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95160786
65Oocyte meiosis_Homo sapiens_hsa041140.92953459
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89593779
67Epstein-Barr virus infection_Homo sapiens_hsa051690.88078042
68Viral carcinogenesis_Homo sapiens_hsa052030.86280215
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85974789
70Wnt signaling pathway_Homo sapiens_hsa043100.84886689
71Malaria_Homo sapiens_hsa051440.83799170
72Galactose metabolism_Homo sapiens_hsa000520.83082181
73Autoimmune thyroid disease_Homo sapiens_hsa053200.82914493
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82467534
75Sulfur relay system_Homo sapiens_hsa041220.80470346
76Regulation of autophagy_Homo sapiens_hsa041400.80420899
77Proteasome_Homo sapiens_hsa030500.79118157
78Hepatitis B_Homo sapiens_hsa051610.78896359
79Purine metabolism_Homo sapiens_hsa002300.76199771
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.75019277
81Focal adhesion_Homo sapiens_hsa045100.74523611
82Prolactin signaling pathway_Homo sapiens_hsa049170.73569944
83Nitrogen metabolism_Homo sapiens_hsa009100.73521904
84Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.73372782
85Collecting duct acid secretion_Homo sapiens_hsa049660.73286384
86Systemic lupus erythematosus_Homo sapiens_hsa053220.73172399
87Pathways in cancer_Homo sapiens_hsa052000.70604281
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70523680
89Arachidonic acid metabolism_Homo sapiens_hsa005900.70071171
90Melanoma_Homo sapiens_hsa052180.69974411
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.69960578
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.69300842
93Hematopoietic cell lineage_Homo sapiens_hsa046400.68211789
94T cell receptor signaling pathway_Homo sapiens_hsa046600.68169428
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67352067
96Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67206063
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67102196
98Rheumatoid arthritis_Homo sapiens_hsa053230.67098278
99Endocytosis_Homo sapiens_hsa041440.66579621
100Ovarian steroidogenesis_Homo sapiens_hsa049130.66275960
101Viral myocarditis_Homo sapiens_hsa054160.66151142
102Lysine degradation_Homo sapiens_hsa003100.66117417
103mTOR signaling pathway_Homo sapiens_hsa041500.65129187
104Vibrio cholerae infection_Homo sapiens_hsa051100.64911468
105Prostate cancer_Homo sapiens_hsa052150.62929136
106Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61701332
107Leishmaniasis_Homo sapiens_hsa051400.61665409
108Pertussis_Homo sapiens_hsa051330.60626277
109Sphingolipid metabolism_Homo sapiens_hsa006000.60567254
110Parkinsons disease_Homo sapiens_hsa050120.60394724
111VEGF signaling pathway_Homo sapiens_hsa043700.59404561
112African trypanosomiasis_Homo sapiens_hsa051430.57855508
113Fat digestion and absorption_Homo sapiens_hsa049750.57343329
114ECM-receptor interaction_Homo sapiens_hsa045120.57324938
115Salmonella infection_Homo sapiens_hsa051320.56763844
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.55392927
117Cyanoamino acid metabolism_Homo sapiens_hsa004600.54366650
118Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54285536
119Tuberculosis_Homo sapiens_hsa051520.53814198
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.53068142
121Primary immunodeficiency_Homo sapiens_hsa053400.52773547
122Circadian rhythm_Homo sapiens_hsa047100.52383078
123Antigen processing and presentation_Homo sapiens_hsa046120.51079259
124Renal cell carcinoma_Homo sapiens_hsa052110.50126655
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49442096
126Fatty acid elongation_Homo sapiens_hsa000620.49272316
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49075841
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47487767
129Adherens junction_Homo sapiens_hsa045200.46978320
130Huntingtons disease_Homo sapiens_hsa050160.46544709
131Phagosome_Homo sapiens_hsa041450.44491152
132Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43938074
133Glioma_Homo sapiens_hsa052140.43825044
134Olfactory transduction_Homo sapiens_hsa047400.43314244
135Toxoplasmosis_Homo sapiens_hsa051450.42759788
136Apoptosis_Homo sapiens_hsa042100.42634990
137ErbB signaling pathway_Homo sapiens_hsa040120.41300890
138B cell receptor signaling pathway_Homo sapiens_hsa046620.41086241
139Asthma_Homo sapiens_hsa053100.40967538
140Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40482120
141Measles_Homo sapiens_hsa051620.40359522
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40138161
143alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39245784
144Central carbon metabolism in cancer_Homo sapiens_hsa052300.38596764
145Shigellosis_Homo sapiens_hsa051310.38290707
146Axon guidance_Homo sapiens_hsa043600.38061487
147Alcoholism_Homo sapiens_hsa050340.36104400
148PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35282449
149FoxO signaling pathway_Homo sapiens_hsa040680.33425757
150AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.33208263
151Pentose phosphate pathway_Homo sapiens_hsa000300.32005339
152Dorso-ventral axis formation_Homo sapiens_hsa043200.31507038
153Neurotrophin signaling pathway_Homo sapiens_hsa047220.30168473
154Proteoglycans in cancer_Homo sapiens_hsa052050.29486204
155MAPK signaling pathway_Homo sapiens_hsa040100.29134354
156AMPK signaling pathway_Homo sapiens_hsa041520.29105281
157Linoleic acid metabolism_Homo sapiens_hsa005910.26564088
158NF-kappa B signaling pathway_Homo sapiens_hsa040640.26046088
159Influenza A_Homo sapiens_hsa051640.25078082
160N-Glycan biosynthesis_Homo sapiens_hsa005100.24906536
161Cysteine and methionine metabolism_Homo sapiens_hsa002700.24341008
162HIF-1 signaling pathway_Homo sapiens_hsa040660.23735046
163Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.23656144
164Melanogenesis_Homo sapiens_hsa049160.22549243

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