BCLAF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.64407426
2nuclear pore organization (GO:0006999)5.34809557
3mitotic sister chromatid cohesion (GO:0007064)5.27730034
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.98713326
5kinetochore organization (GO:0051383)4.71431673
6pore complex assembly (GO:0046931)4.43922188
7mitotic metaphase plate congression (GO:0007080)4.20462129
8double-strand break repair via nonhomologous end joining (GO:0006303)4.19148823
9non-recombinational repair (GO:0000726)4.19148823
10regulation of DNA endoreduplication (GO:0032875)4.11110917
11protein localization to kinetochore (GO:0034501)4.06240514
12metaphase plate congression (GO:0051310)4.03081883
13kinetochore assembly (GO:0051382)4.01072509
14DNA unwinding involved in DNA replication (GO:0006268)3.90889108
15CENP-A containing nucleosome assembly (GO:0034080)3.88847201
16chromatin remodeling at centromere (GO:0031055)3.85940787
17sister chromatid segregation (GO:0000819)3.82142235
18DNA topological change (GO:0006265)3.76396803
19meiotic chromosome segregation (GO:0045132)3.70251004
20mitotic nuclear envelope disassembly (GO:0007077)3.68500136
21mitotic chromosome condensation (GO:0007076)3.68255499
22attachment of spindle microtubules to kinetochore (GO:0008608)3.66147224
23centriole replication (GO:0007099)3.63726054
24regulation of spindle organization (GO:0090224)3.63684540
25DNA replication-independent nucleosome assembly (GO:0006336)3.62369946
26DNA replication-independent nucleosome organization (GO:0034724)3.62369946
27peptidyl-lysine trimethylation (GO:0018023)3.61770682
28positive regulation of histone H3-K4 methylation (GO:0051571)3.60913603
29mitotic sister chromatid segregation (GO:0000070)3.54087912
30negative regulation of DNA-dependent DNA replication (GO:2000104)3.53441374
31DNA replication checkpoint (GO:0000076)3.53418162
32establishment of chromosome localization (GO:0051303)3.52606457
33nuclear envelope disassembly (GO:0051081)3.44348942
34membrane disassembly (GO:0030397)3.44348942
35ribosome assembly (GO:0042255)3.44317728
36DNA replication initiation (GO:0006270)3.44218417
37protein localization to chromosome, centromeric region (GO:0071459)3.42208930
38IMP biosynthetic process (GO:0006188)3.39343137
39regulation of centrosome duplication (GO:0010824)3.38718810
40DNA geometric change (GO:0032392)3.37943877
41DNA duplex unwinding (GO:0032508)3.37084257
42microtubule anchoring (GO:0034453)3.36579138
43DNA ligation (GO:0006266)3.34782890
44positive regulation of mitotic sister chromatid separation (GO:1901970)3.33768098
45positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.33768098
46positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.33768098
47purine nucleobase biosynthetic process (GO:0009113)3.32497069
48sister chromatid cohesion (GO:0007062)3.31468225
49histone exchange (GO:0043486)3.31382242
50mRNA splice site selection (GO:0006376)3.30753745
51mitotic recombination (GO:0006312)3.30452889
52replication fork processing (GO:0031297)3.29265873
53regulation of centriole replication (GO:0046599)3.29123980
54spindle checkpoint (GO:0031577)3.26272795
55DNA strand elongation involved in DNA replication (GO:0006271)3.24406644
56regulation of nuclear cell cycle DNA replication (GO:0033262)3.23668591
57protein K6-linked ubiquitination (GO:0085020)3.21522526
58maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.19498855
59negative regulation of mRNA processing (GO:0050686)3.19237531
60regulation of mitotic metaphase/anaphase transition (GO:0030071)3.18883952
61nucleobase biosynthetic process (GO:0046112)3.18394788
62DNA strand elongation (GO:0022616)3.18171103
63negative regulation of DNA recombination (GO:0045910)3.17393396
64ATP-dependent chromatin remodeling (GO:0043044)3.15968068
65regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.15621136
66regulation of mitotic spindle checkpoint (GO:1903504)3.15621136
67spindle assembly checkpoint (GO:0071173)3.14220124
68telomere maintenance via semi-conservative replication (GO:0032201)3.13970700
69monoubiquitinated protein deubiquitination (GO:0035520)3.12504295
70mitotic G2/M transition checkpoint (GO:0044818)3.11921241
71regulation of mitotic spindle organization (GO:0060236)3.10990469
72regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.09930311
73telomere maintenance via recombination (GO:0000722)3.09583887
74dosage compensation (GO:0007549)3.09029541
75establishment of integrated proviral latency (GO:0075713)3.07811167
76regulation of mitotic sister chromatid separation (GO:0010965)3.07387645
77regulation of mitotic sister chromatid segregation (GO:0033047)3.07387645
78regulation of sister chromatid segregation (GO:0033045)3.07387645
79regulation of RNA export from nucleus (GO:0046831)3.06856844
80positive regulation of chromosome segregation (GO:0051984)3.04267593
81negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.03807360
82negative regulation of sister chromatid segregation (GO:0033046)3.03807360
83negative regulation of mitotic sister chromatid separation (GO:2000816)3.03807360
84negative regulation of mitotic sister chromatid segregation (GO:0033048)3.03807360
85resolution of meiotic recombination intermediates (GO:0000712)3.03033081
86somatic hypermutation of immunoglobulin genes (GO:0016446)3.02775229
87somatic diversification of immune receptors via somatic mutation (GO:0002566)3.02775229
88negative regulation of mRNA metabolic process (GO:1903312)3.02043731
89negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.00655638
90negative regulation of translation, ncRNA-mediated (GO:0040033)3.00655638
91regulation of translation, ncRNA-mediated (GO:0045974)3.00655638
92regulation of DNA damage checkpoint (GO:2000001)3.00595598
93mitotic spindle assembly checkpoint (GO:0007094)3.00239286
94mitotic spindle checkpoint (GO:0071174)3.00103159
95negative regulation of chromosome segregation (GO:0051985)2.99994040
96cytoplasmic mRNA processing body assembly (GO:0033962)2.99813929
97chromosome segregation (GO:0007059)2.99746701
98histone H3-K9 methylation (GO:0051567)2.99166402
99negative regulation of DNA repair (GO:0045738)2.98534244
100negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.98162628
101regulation of chromosome segregation (GO:0051983)2.96057388
102regulation of centrosome cycle (GO:0046605)2.95884629
103DNA conformation change (GO:0071103)2.94721828
104DNA strand renaturation (GO:0000733)2.94718238
105DNA double-strand break processing (GO:0000729)2.93711681
106mismatch repair (GO:0006298)2.93519693
107nucleotide-excision repair, DNA gap filling (GO:0006297)2.93476169
108negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.92663725
109response to X-ray (GO:0010165)2.92536497
110regulation of histone H3-K9 methylation (GO:0051570)2.92040634
111regulation of helicase activity (GO:0051095)2.91059368
112mRNA export from nucleus (GO:0006406)2.90410604
113chromatin assembly or disassembly (GO:0006333)2.90288091
114negative regulation of RNA splicing (GO:0033119)2.89859300
115pre-miRNA processing (GO:0031054)2.88524487
116histone H2A acetylation (GO:0043968)2.87721924
117RNA export from nucleus (GO:0006405)2.87115221
118regulation of sister chromatid cohesion (GO:0007063)2.87081810
119postreplication repair (GO:0006301)2.86238144
120DNA replication-dependent nucleosome organization (GO:0034723)2.85901316
121DNA replication-dependent nucleosome assembly (GO:0006335)2.85901316
122intra-S DNA damage checkpoint (GO:0031573)2.85510205
123regulation of mRNA splicing, via spliceosome (GO:0048024)2.85060685
124telomere maintenance (GO:0000723)2.85043956
125regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.84582974
126mRNA transport (GO:0051028)2.83489997

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.73640877
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.65296742
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.48736749
4* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.48475535
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.33059653
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.32042834
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.09058130
8* MYC_18555785_ChIP-Seq_MESCs_Mouse3.00115073
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.97115677
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.67064141
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.61326192
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.36342787
13* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.33955710
14AR_21909140_ChIP-Seq_LNCAP_Human2.33455801
15PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.24661826
16ELK1_19687146_ChIP-ChIP_HELA_Human2.23173084
17* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.22760114
18* EST1_17652178_ChIP-ChIP_JURKAT_Human2.20961431
19* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16024832
20MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.08705938
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.04484245
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.03827438
23E2F7_22180533_ChIP-Seq_HELA_Human10.9230204
24TAF15_26573619_Chip-Seq_HEK293_Human1.97309395
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.93366342
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.91367084
27IGF1R_20145208_ChIP-Seq_DFB_Human1.88581453
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.84709063
29* VDR_23849224_ChIP-Seq_CD4+_Human1.84157683
30ZNF274_21170338_ChIP-Seq_K562_Hela1.78888648
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.76485184
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.75622224
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.75598880
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.75298753
35* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.73354080
36CIITA_25753668_ChIP-Seq_RAJI_Human1.72437202
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.71023796
38EWS_26573619_Chip-Seq_HEK293_Human1.69967175
39FOXP3_21729870_ChIP-Seq_TREG_Human1.63179986
40HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.61634138
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.59186453
42* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.53601680
43FUS_26573619_Chip-Seq_HEK293_Human1.52353153
44* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.46770017
45* XRN2_22483619_ChIP-Seq_HELA_Human1.46557243
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45257337
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44937480
48* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44618760
49P300_19829295_ChIP-Seq_ESCs_Human1.43481211
50* ETS1_20019798_ChIP-Seq_JURKAT_Human1.41739695
51* TTF2_22483619_ChIP-Seq_HELA_Human1.41472851
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40869483
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38597852
54EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.34844962
55SOX2_18555785_ChIP-Seq_MESCs_Mouse1.34268345
56JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.33466492
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32477764
58VDR_22108803_ChIP-Seq_LS180_Human1.28967117
59* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28913168
60DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.28297308
61KDM5A_27292631_Chip-Seq_BREAST_Human1.28137664
62DCP1A_22483619_ChIP-Seq_HELA_Human1.27964046
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27882765
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27653669
65E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.26727868
66* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24870198
67RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.23997061
68GBX2_23144817_ChIP-Seq_PC3_Human1.22821887
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21988519
70ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21427448
71SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.20729033
72* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.19478706
73* EZH2_27294783_Chip-Seq_NPCs_Mouse1.19274208
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19064227
75* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16449593
76GABP_19822575_ChIP-Seq_HepG2_Human1.15052975
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13794356
78SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13731369
79FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.13594901
80ER_23166858_ChIP-Seq_MCF-7_Human1.11474072
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10135650
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09547978
83NOTCH1_21737748_ChIP-Seq_TLL_Human1.09456206
84PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08986478
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08389471
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07919451
87STAT3_23295773_ChIP-Seq_U87_Human1.07909569
88* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07463311
89CBP_20019798_ChIP-Seq_JUKART_Human1.06693518
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06693518
91POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05221279
92ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05214719
93CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04871354
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.04243029
95SMAD4_21799915_ChIP-Seq_A2780_Human1.03738324
96CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02481212
97BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02387320
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02304360
99MYC_22102868_ChIP-Seq_BL_Human1.02230668
100NFE2_27457419_Chip-Seq_LIVER_Mouse1.01842816
101* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01336002
102* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01181251
103NANOG_18555785_ChIP-Seq_MESCs_Mouse0.98401741
104POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97029893
105FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96851497
106* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96708001
107* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96521964
108EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96252905
109PKCTHETA_26484144_Chip-Seq_BREAST_Human0.95711443
110E2F1_18555785_Chip-Seq_ESCs_Mouse0.94687957
111* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.93113345
112SMAD3_21741376_ChIP-Seq_EPCs_Human0.92716312
113PIAS1_25552417_ChIP-Seq_VCAP_Human0.91818934
114* SOX2_16153702_ChIP-ChIP_HESCs_Human0.91592905
115UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91378309
116ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91361405
117P300_18555785_Chip-Seq_ESCs_Mouse0.91098714
118TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89598600
119P53_22387025_ChIP-Seq_ESCs_Mouse0.88994842
120SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.88804161
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88530015
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88530015
123CMYC_18555785_Chip-Seq_ESCs_Mouse0.88429174
124FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.86947313
125GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85242221
126* MYC_18940864_ChIP-ChIP_HL60_Human0.84008110
127FLI1_27457419_Chip-Seq_LIVER_Mouse0.83788856
128TFEB_21752829_ChIP-Seq_HELA_Human0.83612026
129* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.83601248
130NANOG_21062744_ChIP-ChIP_HESCs_Human0.83394117
131RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.83062675
132* NANOG_16153702_ChIP-ChIP_HESCs_Human0.81070309
133CHD1_26751641_Chip-Seq_LNCaP_Human0.76779537
134SRF_21415370_ChIP-Seq_HL-1_Mouse0.72860369
135* BRD4_25478319_ChIP-Seq_HGPS_Human0.71526018
136YY1_21170310_ChIP-Seq_MESCs_Mouse0.70860996
137GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.70796321
138NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.68973384
139IRF1_19129219_ChIP-ChIP_H3396_Human0.67805417
140CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.67213615
141SOX17_20123909_ChIP-Seq_XEN_Mouse0.65507161
142SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.64911638
143SOX9_26525672_Chip-Seq_HEART_Mouse0.64752303

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.07878034
2MP0010094_abnormal_chromosome_stability4.04840302
3MP0003693_abnormal_embryo_hatching3.28572389
4MP0008058_abnormal_DNA_repair3.21707879
5MP0003111_abnormal_nucleus_morphology3.18564652
6MP0003077_abnormal_cell_cycle3.08678261
7MP0008877_abnormal_DNA_methylation3.01142523
8MP0003123_paternal_imprinting2.93153374
9MP0003121_genomic_imprinting2.84616252
10MP0004957_abnormal_blastocyst_morpholog2.80437256
11MP0008007_abnormal_cellular_replicative2.72992853
12MP0003787_abnormal_imprinting2.68973737
13MP0002396_abnormal_hematopoietic_system2.30296140
14MP0000569_abnormal_digit_pigmentation1.92410757
15MP0008932_abnormal_embryonic_tissue1.83948385
16MP0002009_preneoplasia1.79387328
17MP0003890_abnormal_embryonic-extraembry1.79113291
18MP0000350_abnormal_cell_proliferation1.77665835
19MP0003122_maternal_imprinting1.75528053
20MP0004808_abnormal_hematopoietic_stem1.71522399
21MP0010352_gastrointestinal_tract_polyps1.69912064
22MP0010307_abnormal_tumor_latency1.68529602
23MP0001730_embryonic_growth_arrest1.64263269
24MP0005380_embryogenesis_phenotype1.59670908
25MP0001672_abnormal_embryogenesis/_devel1.59670908
26MP0002638_abnormal_pupillary_reflex1.55287598
27MP0002102_abnormal_ear_morphology1.52990487
28MP0003984_embryonic_growth_retardation1.52505174
29MP0002938_white_spotting1.50051267
30MP0003786_premature_aging1.49149076
31MP0004197_abnormal_fetal_growth/weight/1.48964903
32MP0002088_abnormal_embryonic_growth/wei1.48769870
33MP0001697_abnormal_embryo_size1.46774274
34MP0002084_abnormal_developmental_patter1.45941106
35MP0001293_anophthalmia1.45366011
36MP0006292_abnormal_olfactory_placode1.44983631
37MP0009053_abnormal_anal_canal1.43914569
38MP0002085_abnormal_embryonic_tissue1.41219010
39MP0005367_renal/urinary_system_phenotyp1.40079200
40MP0000516_abnormal_urinary_system1.40079200
41MP0003937_abnormal_limbs/digits/tail_de1.39665910
42MP0005187_abnormal_penis_morphology1.39236932
43MP0003567_abnormal_fetal_cardiomyocyte1.39214190
44MP0002086_abnormal_extraembryonic_tissu1.37088751
45MP0005076_abnormal_cell_differentiation1.35904838
46MP0000537_abnormal_urethra_morphology1.22959224
47MP0009703_decreased_birth_body1.22443793
48MP0003943_abnormal_hepatobiliary_system1.20892893
49MP0003315_abnormal_perineum_morphology1.20839039
50MP0009697_abnormal_copulation1.20629044
51MP0010030_abnormal_orbit_morphology1.19814022
52MP0003941_abnormal_skin_development1.19072884
53MP0008995_early_reproductive_senescence1.17477280
54MP0002080_prenatal_lethality1.14873168
55MP0006072_abnormal_retinal_apoptosis1.12907977
56MP0006054_spinal_hemorrhage1.12206352
57MP0003935_abnormal_craniofacial_develop1.12170105
58MP0003755_abnormal_palate_morphology1.07629865
59MP0002877_abnormal_melanocyte_morpholog1.07611342
60MP0000566_synostosis1.07269759
61MP0002160_abnormal_reproductive_system1.06415466
62MP0008789_abnormal_olfactory_epithelium1.05830258
63MP0003718_maternal_effect1.04893500
64MP0001286_abnormal_eye_development1.04445307
65MP0002210_abnormal_sex_determination1.04014554
66MP0003385_abnormal_body_wall1.03286486
67MP0002095_abnormal_skin_pigmentation1.03253631
68MP0000313_abnormal_cell_death1.03014785
69* MP0003115_abnormal_respiratory_system1.02163593
70MP0009672_abnormal_birth_weight1.01856765
71MP0001188_hyperpigmentation1.00977869
72MP0000432_abnormal_head_morphology0.99042176
73MP0003221_abnormal_cardiomyocyte_apopto0.98948931
74MP0000383_abnormal_hair_follicle0.98708224
75MP0000427_abnormal_hair_cycle0.98198354
76MP0001929_abnormal_gametogenesis0.97922887
77MP0003942_abnormal_urinary_system0.97835191
78MP0003119_abnormal_digestive_system0.96463973
79MP0000049_abnormal_middle_ear0.95985800
80MP0000428_abnormal_craniofacial_morphol0.93417542
81MP0001119_abnormal_female_reproductive0.92672215
82MP0005389_reproductive_system_phenotype0.90957154
83MP0000703_abnormal_thymus_morphology0.88487214
84MP0000647_abnormal_sebaceous_gland0.88473736
85MP0001177_atelectasis0.88343154
86MP0001145_abnormal_male_reproductive0.87641460
87MP0000490_abnormal_crypts_of0.87158630
88MP0010678_abnormal_skin_adnexa0.85724344
89MP0002233_abnormal_nose_morphology0.85646213
90MP0002751_abnormal_autonomic_nervous0.85429773
91MP0000015_abnormal_ear_pigmentation0.85352021
92MP0000631_abnormal_neuroendocrine_gland0.85079013
93MP0000613_abnormal_salivary_gland0.84771533
94MP0009250_abnormal_appendicular_skeleto0.83023477
95MP0005394_taste/olfaction_phenotype0.82853854
96MP0005499_abnormal_olfactory_system0.82853854
97MP0002925_abnormal_cardiovascular_devel0.80256958
98MP0004264_abnormal_extraembryonic_tissu0.80156718
99MP0002166_altered_tumor_susceptibility0.79739463
100MP0000653_abnormal_sex_gland0.79476449
101MP0000678_abnormal_parathyroid_gland0.78953763
102MP0002177_abnormal_outer_ear0.78669850
103MP0005220_abnormal_exocrine_pancreas0.78546833
104MP0002006_tumorigenesis0.77899500
105MP0005391_vision/eye_phenotype0.77778269
106MP0002019_abnormal_tumor_incidence0.77375287
107MP0008961_abnormal_basal_metabolism0.76930451
108MP0005503_abnormal_tendon_morphology0.76643455
109MP0002116_abnormal_craniofacial_bone0.76599744
110MP0002092_abnormal_eye_morphology0.76570520
111MP0004147_increased_porphyrin_level0.76153079
112MP0002114_abnormal_axial_skeleton0.75549483
113* MP0002109_abnormal_limb_morphology0.75027566
114MP0002697_abnormal_eye_size0.74636664
115MP0002111_abnormal_tail_morphology0.73844561
116MP0005248_abnormal_Harderian_gland0.73178231
117MP0001915_intracranial_hemorrhage0.73045953
118MP0003763_abnormal_thymus_physiology0.72759920
119MP0005253_abnormal_eye_physiology0.72222142
120MP0005409_darkened_coat_color0.71785113
121MP0001919_abnormal_reproductive_system0.70065719
122MP0003861_abnormal_nervous_system0.69456201
123MP0000778_abnormal_nervous_system0.67319425
124MP0002081_perinatal_lethality0.62099997
125MP0003698_abnormal_male_reproductive0.59197158
126MP0001529_abnormal_vocalization0.58577434

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.20715453
2Volvulus (HP:0002580)4.00801711
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.78783092
4Birth length less than 3rd percentile (HP:0003561)3.38023605
5Ectopic kidney (HP:0000086)3.05336088
6Abnormality of chromosome stability (HP:0003220)3.04465994
7Colon cancer (HP:0003003)3.02303926
8Short 4th metacarpal (HP:0010044)2.97198479
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.97198479
10Medulloblastoma (HP:0002885)2.93516446
11Abnormality of the fingertips (HP:0001211)2.69439117
12Meckel diverticulum (HP:0002245)2.65952358
13Papillary thyroid carcinoma (HP:0002895)2.65372597
14Abnormality of the labia minora (HP:0012880)2.64684340
15Long eyelashes (HP:0000527)2.61815804
16Nephroblastoma (Wilms tumor) (HP:0002667)2.57639525
17Cystic hygroma (HP:0000476)2.52814620
18Embryonal renal neoplasm (HP:0011794)2.52588433
19Abnormality of the ileum (HP:0001549)2.48539085
20Aplasia/Hypoplasia of the uvula (HP:0010293)2.48192730
21Patellar aplasia (HP:0006443)2.46518643
22Abnormality of the preputium (HP:0100587)2.44681479
23Deep philtrum (HP:0002002)2.44600990
24Curly hair (HP:0002212)2.42285944
25Acute myeloid leukemia (HP:0004808)2.39895791
26Abnormal lung lobation (HP:0002101)2.39127495
27Increased nuchal translucency (HP:0010880)2.37220947
28Syringomyelia (HP:0003396)2.36319367
29Spinal cord lesions (HP:0100561)2.36319367
30Myelodysplasia (HP:0002863)2.35564516
31Small intestinal stenosis (HP:0012848)2.34065346
32Duodenal stenosis (HP:0100867)2.34065346
33Aplasia/Hypoplasia of the patella (HP:0006498)2.28207662
34Impulsivity (HP:0100710)2.25539377
35Aplasia/Hypoplasia of the sternum (HP:0006714)2.17728500
36Pancreatic cysts (HP:0001737)2.15438860
37Abnormal number of incisors (HP:0011064)2.14545917
38Aplasia/Hypoplasia of the fovea (HP:0008060)2.13791247
39Hypoplasia of the fovea (HP:0007750)2.13791247
40Lip pit (HP:0100267)2.10105053
41Hepatoblastoma (HP:0002884)2.09669395
42Ependymoma (HP:0002888)2.09135073
43Abnormality of the nasal septum (HP:0000419)2.07214677
44Deviation of the thumb (HP:0009603)2.06896532
45Short middle phalanx of the 5th finger (HP:0004220)2.06075975
46Abnormal hair whorl (HP:0010721)2.04108982
47Neoplasm of the adrenal cortex (HP:0100641)2.02906122
4811 pairs of ribs (HP:0000878)2.02392885
49Proximal placement of thumb (HP:0009623)1.99527070
50Optic nerve coloboma (HP:0000588)1.99484354
51Neoplasm of striated muscle (HP:0009728)1.98560594
52Agnosia (HP:0010524)1.96913774
53Abnormality of the duodenum (HP:0002246)1.95969416
54Glioma (HP:0009733)1.95482570
55Abnormality of the carotid arteries (HP:0005344)1.94892681
56Gaze-evoked nystagmus (HP:0000640)1.93608557
57Pancreatic islet-cell hyperplasia (HP:0004510)1.93349422
58Hyperventilation (HP:0002883)1.93053660
59Truncal obesity (HP:0001956)1.93014927
60Sandal gap (HP:0001852)1.92792587
61Sloping forehead (HP:0000340)1.92716687
62Abnormality of the incisor (HP:0000676)1.92679310
63Neoplasm of the small intestine (HP:0100833)1.90296104
64Rhabdomyosarcoma (HP:0002859)1.90145695
65Overlapping toe (HP:0001845)1.89034426
66Long clavicles (HP:0000890)1.87469969
67Abnormality of the 4th metacarpal (HP:0010012)1.87045141
68Abnormality of the renal collecting system (HP:0004742)1.87043243
69Atresia of the external auditory canal (HP:0000413)1.86644489
70Asymmetry of the thorax (HP:0001555)1.86364113
71Supernumerary spleens (HP:0009799)1.86266459
72Abnormality of the fovea (HP:0000493)1.85908562
73Thyroid carcinoma (HP:0002890)1.85655054
74Aqueductal stenosis (HP:0002410)1.85371474
75Oligodactyly (hands) (HP:0001180)1.82423236
76True hermaphroditism (HP:0010459)1.82422797
77Embryonal neoplasm (HP:0002898)1.81805479
78Prominent nose (HP:0000448)1.81317211
79Renal cortical cysts (HP:0000803)1.81224628
80Selective tooth agenesis (HP:0001592)1.80543302
81Medial flaring of the eyebrow (HP:0010747)1.80489744
82Amyotrophic lateral sclerosis (HP:0007354)1.80459465
83Abnormality of the astrocytes (HP:0100707)1.79566871
84Astrocytoma (HP:0009592)1.79566871
85Shawl scrotum (HP:0000049)1.79084965
86Poor coordination (HP:0002370)1.78868161
87Biliary tract neoplasm (HP:0100574)1.78846222
88Nephronophthisis (HP:0000090)1.78549613
89Drooling (HP:0002307)1.78249293
90Pancreatic fibrosis (HP:0100732)1.77573874
91Hip dysplasia (HP:0001385)1.76918304
92Abnormality of midbrain morphology (HP:0002418)1.76466511
93Molar tooth sign on MRI (HP:0002419)1.76466511
94Abnormality of chromosome segregation (HP:0002916)1.76419558
95Aplastic anemia (HP:0001915)1.75908285
96Abnormality of the anterior horn cell (HP:0006802)1.75670995
97Degeneration of anterior horn cells (HP:0002398)1.75670995
98Facial cleft (HP:0002006)1.72989723
99Gonadotropin excess (HP:0000837)1.72974701
100Clubbing of toes (HP:0100760)1.71783214
101Mesomelia (HP:0003027)1.71693260
102Neoplasm of the oral cavity (HP:0100649)1.71611162
103Neoplasm of the colon (HP:0100273)1.71491808
104Small hand (HP:0200055)1.70559240
105Trigonocephaly (HP:0000243)1.70408883
106Cafe-au-lait spot (HP:0000957)1.69819670
107Abnormality of the columella (HP:0009929)1.69041292
108Acute lymphatic leukemia (HP:0006721)1.68970551
109Midline defect of the nose (HP:0004122)1.67927586
110Chronic hepatic failure (HP:0100626)1.67898570
111Abnormality of the renal cortex (HP:0011035)1.67817328
112Intestinal atresia (HP:0011100)1.67729382
113Abnormal biliary tract morphology (HP:0012440)1.67348998
114Premature graying of hair (HP:0002216)1.67167263
115Congenital primary aphakia (HP:0007707)1.66840025
116Increased number of teeth (HP:0011069)1.66620964
117Broad thumb (HP:0011304)1.66082889
118Breast carcinoma (HP:0003002)1.65599014
119Renal duplication (HP:0000075)1.65358331
120Anal stenosis (HP:0002025)1.65081024
121Absent frontal sinuses (HP:0002688)1.65017184
122Malignant gastrointestinal tract tumors (HP:0006749)1.64792529
123Gastrointestinal carcinoma (HP:0002672)1.64792529
124Bone marrow hypocellularity (HP:0005528)1.64494827
125Hypoplasia of the maxilla (HP:0000327)1.64238761
126Abnormality of the renal medulla (HP:0100957)1.64088837
127Low anterior hairline (HP:0000294)1.63645996
128Triphalangeal thumb (HP:0001199)1.62813426
129Astigmatism (HP:0000483)1.62376569
130Urethral obstruction (HP:0000796)1.62143566
131Broad palm (HP:0001169)1.61893112
132Skull defect (HP:0001362)1.60634784
133Tubulointerstitial nephritis (HP:0001970)1.59666196
134Abnormality of DNA repair (HP:0003254)1.59466872
135Cutis marmorata (HP:0000965)1.59240887
136Protruding tongue (HP:0010808)1.58072939
137Excessive salivation (HP:0003781)1.57721804
138Absent radius (HP:0003974)1.57659960
139Capillary hemangiomas (HP:0005306)1.57559109
140Dandy-Walker malformation (HP:0001305)1.57379432
141Abnormality of the parietal bone (HP:0002696)1.56437864
142Short thumb (HP:0009778)1.56385305
143Missing ribs (HP:0000921)1.56204727
144Breast hypoplasia (HP:0003187)1.55994111
145Gait imbalance (HP:0002141)1.55386622
146Bifid tongue (HP:0010297)1.54821086
147Highly arched eyebrow (HP:0002553)1.53653518
148Oculomotor apraxia (HP:0000657)1.53608899
149Ovarian neoplasm (HP:0100615)1.53553506
150Optic nerve hypoplasia (HP:0000609)1.52652699

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.78333394
2SRPK13.19035239
3MKNK13.17367260
4MKNK23.00562447
5TSSK62.74262387
6ZAK2.71120754
7CDK122.63930465
8BRSK22.63348472
9WEE12.57454979
10PLK32.52123589
11NEK22.17072871
12AKT32.12616106
13ACVR1B2.09985736
14ATR2.07448653
15PLK42.06420991
16WNK32.00304554
17BRD41.90525537
18BUB11.89598340
19TTK1.84973291
20PASK1.82653813
21NUAK11.81434911
22ERBB31.79427498
23MST41.72499832
24TRIM281.72115598
25NEK11.71259031
26MAP3K41.70303496
27PLK11.69487376
28VRK11.67265381
29CHEK21.52114880
30AURKB1.50241232
31FRK1.46470930
32EIF2AK11.42881185
33LATS11.42705449
34ATM1.42433248
35CHEK11.42425753
36CCNB11.41988285
37TAF11.41435464
38BRSK11.34517953
39CDK81.33673750
40TNIK1.28649799
41CDK71.26798711
42EIF2AK31.19670420
43CASK1.19160167
44STK31.16459096
45BMPR1B1.14795026
46TGFBR11.10592903
47SIK31.09338983
48MAP3K101.04864730
49SGK21.03568522
50PLK21.02816223
51* CDK21.00920587
52YES10.94181949
53CDK60.94179337
54EIF2AK20.92606622
55* CDK10.91755572
56STK40.90209103
57STK38L0.88333084
58RPS6KB20.83636858
59TEC0.82817687
60NLK0.82559220
61CSNK1G10.81420151
62CDK40.80170303
63MELK0.80075837
64CDK30.76366355
65TIE10.75628518
66MAP4K20.75020782
67DYRK30.71823048
68RPS6KA40.70057581
69PBK0.69562898
70STK100.68402610
71TAOK30.68003786
72CLK10.66665414
73MAPK140.66637947
74SGK30.62911478
75CDK90.62868003
76NEK60.62783874
77CAMK1D0.62322373
78PRKDC0.61938832
79RPS6KB10.61283379
80MARK30.60707806
81ALK0.59855789
82STK390.59796710
83PIM10.58632555
84CSNK2A20.56432632
85MAP2K70.55788973
86BCR0.55323219
87CHUK0.55194885
88PNCK0.54438712
89CSNK1G20.53312729
90FLT30.53014818
91FGFR30.52427236
92PAK30.52415991
93TXK0.50625241
94CSNK2A10.48620764
95TRPM70.48576085
96MAP3K60.48091410
97FGFR10.47619968
98NEK90.47538053
99CSNK1G30.46356034
100* GSK3B0.46269856
101RAF10.44244955
102MTOR0.43683328
103MAP3K80.43571669
104AURKA0.42147306
105MAPK130.41238932
106DYRK1A0.40664468
107STK240.40584299
108CSNK1A1L0.40578711
109SCYL20.40512600
110TLK10.39900111
111CSNK1E0.39682725
112AKT10.39218623
113TAOK20.37660690
114PIK3CA0.37610339
115UHMK10.36957020
116FGFR20.36053929
117CAMK1G0.35091795
118CSNK1D0.35040622
119MAP3K140.34521366
120BMPR20.33455838
121MAPK10.33166191
122IRAK20.31539396
123EEF2K0.31029528
124MAPK100.30745478
125STK160.30696905
126RPS6KA50.30316175
127PRKACB0.28970866

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.80160985
2Mismatch repair_Homo sapiens_hsa034303.79655298
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.24622258
4Cell cycle_Homo sapiens_hsa041103.09154312
5Spliceosome_Homo sapiens_hsa030403.00691377
6RNA transport_Homo sapiens_hsa030132.97890234
7Homologous recombination_Homo sapiens_hsa034402.88947831
8Non-homologous end-joining_Homo sapiens_hsa034502.81271411
9Fanconi anemia pathway_Homo sapiens_hsa034602.75226353
10Base excision repair_Homo sapiens_hsa034102.67065101
11Nucleotide excision repair_Homo sapiens_hsa034202.45213756
12RNA degradation_Homo sapiens_hsa030182.43610675
13mRNA surveillance pathway_Homo sapiens_hsa030152.38395703
14RNA polymerase_Homo sapiens_hsa030202.18259827
15Basal transcription factors_Homo sapiens_hsa030222.13137045
16One carbon pool by folate_Homo sapiens_hsa006701.90484429
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.85763374
18p53 signaling pathway_Homo sapiens_hsa041151.55455215
19Pyrimidine metabolism_Homo sapiens_hsa002401.49178031
20Propanoate metabolism_Homo sapiens_hsa006401.45206291
21Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.43348158
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.38487932
23Selenocompound metabolism_Homo sapiens_hsa004501.32835201
24MicroRNAs in cancer_Homo sapiens_hsa052061.32241321
25Systemic lupus erythematosus_Homo sapiens_hsa053221.27159685
26Circadian rhythm_Homo sapiens_hsa047101.24819258
27Oocyte meiosis_Homo sapiens_hsa041141.22859017
28Herpes simplex infection_Homo sapiens_hsa051681.20457221
29Epstein-Barr virus infection_Homo sapiens_hsa051691.18766839
30Viral carcinogenesis_Homo sapiens_hsa052031.18011301
31Transcriptional misregulation in cancer_Homo sapiens_hsa052021.16364672
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.16114870
33TGF-beta signaling pathway_Homo sapiens_hsa043501.13345931
34HTLV-I infection_Homo sapiens_hsa051661.12887144
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.07961878
36Proteasome_Homo sapiens_hsa030501.07557492
37Antigen processing and presentation_Homo sapiens_hsa046121.07091472
38Colorectal cancer_Homo sapiens_hsa052101.04578791
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.02405408
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.00339782
41Purine metabolism_Homo sapiens_hsa002301.00096105
42Thyroid cancer_Homo sapiens_hsa052160.99769826
43Adherens junction_Homo sapiens_hsa045200.99393528
44Prostate cancer_Homo sapiens_hsa052150.97334441
45Maturity onset diabetes of the young_Homo sapiens_hsa049500.97001399
46Basal cell carcinoma_Homo sapiens_hsa052170.93395075
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.91234127
48Small cell lung cancer_Homo sapiens_hsa052220.89801791
49Hippo signaling pathway_Homo sapiens_hsa043900.85342486
50Alcoholism_Homo sapiens_hsa050340.83364445
51Wnt signaling pathway_Homo sapiens_hsa043100.79135458
52Endometrial cancer_Homo sapiens_hsa052130.78316577
53Steroid biosynthesis_Homo sapiens_hsa001000.77633896
54Protein export_Homo sapiens_hsa030600.76737581
55Hepatitis B_Homo sapiens_hsa051610.76590909
56Chronic myeloid leukemia_Homo sapiens_hsa052200.75710659
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72545105
58Ribosome_Homo sapiens_hsa030100.70092373
59Melanoma_Homo sapiens_hsa052180.67949842
60Pathways in cancer_Homo sapiens_hsa052000.67507096
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66773180
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66639463
63FoxO signaling pathway_Homo sapiens_hsa040680.65624560
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61438869
65Lysine degradation_Homo sapiens_hsa003100.60797447
66Non-small cell lung cancer_Homo sapiens_hsa052230.60077352
67Pancreatic cancer_Homo sapiens_hsa052120.59710127
68Notch signaling pathway_Homo sapiens_hsa043300.59448303
69Measles_Homo sapiens_hsa051620.59400356
70N-Glycan biosynthesis_Homo sapiens_hsa005100.58462656
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58305518
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55852792
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55814399
74Dorso-ventral axis formation_Homo sapiens_hsa043200.55538496
75Hedgehog signaling pathway_Homo sapiens_hsa043400.55448449
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53841669
77Vitamin B6 metabolism_Homo sapiens_hsa007500.53535329
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53529415
79Viral myocarditis_Homo sapiens_hsa054160.53338232
80Influenza A_Homo sapiens_hsa051640.52076663
81NF-kappa B signaling pathway_Homo sapiens_hsa040640.51414356
82Legionellosis_Homo sapiens_hsa051340.49746097
83Primary immunodeficiency_Homo sapiens_hsa053400.49651083
84Taste transduction_Homo sapiens_hsa047420.46612030
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46026780
86Inositol phosphate metabolism_Homo sapiens_hsa005620.45861809
87Proteoglycans in cancer_Homo sapiens_hsa052050.45639889
88mTOR signaling pathway_Homo sapiens_hsa041500.45100567
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45056303
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44732364
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42825246
92Butanoate metabolism_Homo sapiens_hsa006500.42396128
93Regulation of autophagy_Homo sapiens_hsa041400.41908101
94Glioma_Homo sapiens_hsa052140.40753042
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40498152
96Phototransduction_Homo sapiens_hsa047440.39404794
97Olfactory transduction_Homo sapiens_hsa047400.39294559
98HIF-1 signaling pathway_Homo sapiens_hsa040660.38851368
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38422292
100Focal adhesion_Homo sapiens_hsa045100.35531323
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35222215
102Apoptosis_Homo sapiens_hsa042100.34753496
103Nitrogen metabolism_Homo sapiens_hsa009100.34609605
104Type I diabetes mellitus_Homo sapiens_hsa049400.33586042
105Acute myeloid leukemia_Homo sapiens_hsa052210.32925293
106T cell receptor signaling pathway_Homo sapiens_hsa046600.32026880
107Hematopoietic cell lineage_Homo sapiens_hsa046400.31453281
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29319615
109Tight junction_Homo sapiens_hsa045300.28271348
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.26356730
111Intestinal immune network for IgA production_Homo sapiens_hsa046720.26163227
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.26152406
113ErbB signaling pathway_Homo sapiens_hsa040120.24799215
114Amphetamine addiction_Homo sapiens_hsa050310.24285854
115Melanogenesis_Homo sapiens_hsa049160.24258499
116Long-term depression_Homo sapiens_hsa047300.24216221
117MAPK signaling pathway_Homo sapiens_hsa040100.23813703
118Prolactin signaling pathway_Homo sapiens_hsa049170.23033523
119Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.22772569
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.22762475
121RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22665532
122Toxoplasmosis_Homo sapiens_hsa051450.21872487
123Rap1 signaling pathway_Homo sapiens_hsa040150.21831074
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.20903972
125TNF signaling pathway_Homo sapiens_hsa046680.20566146
126Choline metabolism in cancer_Homo sapiens_hsa052310.19493166
127Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.19313150
128Shigellosis_Homo sapiens_hsa051310.19131104
129Platelet activation_Homo sapiens_hsa046110.17755679
130Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.17618766
131ECM-receptor interaction_Homo sapiens_hsa045120.16910865
132Long-term potentiation_Homo sapiens_hsa047200.16683199
133Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.15241354
134Pyruvate metabolism_Homo sapiens_hsa006200.15112404
135Dopaminergic synapse_Homo sapiens_hsa047280.13231280

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