ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.62754687
2	response to pheromone (GO:0019236)	5.99572729
3	water-soluble vitamin biosynthetic process (GO:0042364)	5.48313125
4	cytidine metabolic process (GO:0046087)	5.22873704
5	cytidine catabolic process (GO:0006216)	5.22873704
6	cytidine deamination (GO:0009972)	5.22873704
7	behavioral response to nicotine (GO:0035095)	4.73611912
8	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.63592622
9	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.61952634
10	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.54156517
11	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.30366304
12	ATP synthesis coupled proton transport (GO:0015986)	4.30366304
13	rRNA modification (GO:0000154)	4.21655415
14	positive regulation of prostaglandin secretion (GO:0032308)	4.17063214
15	signal peptide processing (GO:0006465)	4.09862600
16	L-fucose catabolic process (GO:0042355)	4.05662908
17	fucose catabolic process (GO:0019317)	4.05662908
18	L-fucose metabolic process (GO:0042354)	4.05662908
19	rRNA methylation (GO:0031167)	4.00377336
20	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.97855176
21	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.94356620
22	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.85522424
23	metallo-sulfur cluster assembly (GO:0031163)	3.82492890
24	iron-sulfur cluster assembly (GO:0016226)	3.82492890
25	cellular ketone body metabolic process (GO:0046950)	3.77985995
26	protein complex biogenesis (GO:0070271)	3.76522159
27	protein neddylation (GO:0045116)	3.60750067
28	mitochondrial respiratory chain complex assembly (GO:0033108)	3.59586411
29	positive regulation of defense response to virus by host (GO:0002230)	3.51340564
30	respiratory chain complex IV assembly (GO:0008535)	3.43491841
31	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.36229504
32	ketone body metabolic process (GO:1902224)	3.31552886
33	protein-cofactor linkage (GO:0018065)	3.28667319
34	DNA double-strand break processing (GO:0000729)	3.28432543
35	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.27878476
36	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.27878476
37	NADH dehydrogenase complex assembly (GO:0010257)	3.27878476
38	regulation of prostaglandin secretion (GO:0032306)	3.25931635
39	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.25166389
40	positive regulation of cell fate commitment (GO:0010455)	3.21452583
41	electron transport chain (GO:0022900)	3.13752866
42	respiratory electron transport chain (GO:0022904)	3.12646079
43	positive regulation of fatty acid transport (GO:2000193)	3.11551992
44	pseudouridine synthesis (GO:0001522)	3.07664875
45	chaperone-mediated protein transport (GO:0072321)	3.04881026
46	platelet dense granule organization (GO:0060155)	2.89315128
47	cytochrome complex assembly (GO:0017004)	2.87899332
48	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.81970315
49	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.81970315
50	kynurenine metabolic process (GO:0070189)	2.81231270
51	negative regulation of telomere maintenance (GO:0032205)	2.80817957
52	positive regulation of icosanoid secretion (GO:0032305)	2.78830850
53	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.75414776
54	termination of RNA polymerase III transcription (GO:0006386)	2.75414776
55	cullin deneddylation (GO:0010388)	2.74939707
56	indolalkylamine metabolic process (GO:0006586)	2.74837778
57	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.73466948
58	regulation of mitotic spindle checkpoint (GO:1903504)	2.73466948
59	nucleobase biosynthetic process (GO:0046112)	2.72181754
60	recombinational repair (GO:0000725)	2.68618158
61	nonmotile primary cilium assembly (GO:0035058)	2.65142455
62	mannosylation (GO:0097502)	2.64951879
63	vitamin biosynthetic process (GO:0009110)	2.64805150
64	hydrogen ion transmembrane transport (GO:1902600)	2.63809463
65	double-strand break repair via homologous recombination (GO:0000724)	2.60832186
66	lactate metabolic process (GO:0006089)	2.60581656
67	regulation of glucokinase activity (GO:0033131)	2.60500403
68	regulation of hexokinase activity (GO:1903299)	2.60500403
69	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.60204096
70	sequestering of actin monomers (GO:0042989)	2.60165244
71	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.59966399
72	protein deneddylation (GO:0000338)	2.58440949
73	tRNA processing (GO:0008033)	2.55390679
74	synaptic transmission, cholinergic (GO:0007271)	2.53248760
75	negative regulation by host of viral transcription (GO:0043922)	2.51982950
76	proton transport (GO:0015992)	2.50440438
77	centriole replication (GO:0007099)	2.49486299
78	transcription from mitochondrial promoter (GO:0006390)	2.48810355
79	protein polyglutamylation (GO:0018095)	2.44125286
80	piRNA metabolic process (GO:0034587)	2.43356888
81	chromatin remodeling at centromere (GO:0031055)	2.43169544
82	hydrogen transport (GO:0006818)	2.42685662
83	endoderm formation (GO:0001706)	2.40943828
84	ATP biosynthetic process (GO:0006754)	2.37611172
85	positive regulation of protein homooligomerization (GO:0032464)	2.36541825
86	preassembly of GPI anchor in ER membrane (GO:0016254)	2.34345119
87	positive regulation of transcription regulatory region DNA binding (GO:2000679)	2.33239928
88	establishment of protein localization to mitochondrion (GO:0072655)	2.32239195
89	indole-containing compound catabolic process (GO:0042436)	2.31230918
90	indolalkylamine catabolic process (GO:0046218)	2.31230918
91	tryptophan catabolic process (GO:0006569)	2.31230918
92	GPI anchor metabolic process (GO:0006505)	2.30018755
93	male meiosis (GO:0007140)	2.29700221
94	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.29536431
95	protein targeting to mitochondrion (GO:0006626)	2.29060443
96	rRNA catabolic process (GO:0016075)	2.28954670
97	gamma-aminobutyric acid transport (GO:0015812)	2.28699703
98	intracellular protein transmembrane import (GO:0044743)	2.27612735
99	regulation of immunoglobulin secretion (GO:0051023)	2.25432253
100	positive regulation of T cell apoptotic process (GO:0070234)	2.25322777

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.76689642
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.95599719
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.33423257
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.29176306
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.90700872
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.59692135
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.54722185
8	VDR_22108803_ChIP-Seq_LS180_Human	2.54706957
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.44983720
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.44106862
11	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.37244106
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.33323956
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.29055834
14	EWS_26573619_Chip-Seq_HEK293_Human	2.15718838
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.15383436
16	ELK1_19687146_ChIP-ChIP_HELA_Human	2.06878694
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.01955936
18	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.00727325
19	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.97121055
20	MYC_18940864_ChIP-ChIP_HL60_Human	1.85997920
21	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.82262931
22	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.81869386
23	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.78935377
24	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.77970757
25	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.73593282
26	FOXP3_21729870_ChIP-Seq_TREG_Human	1.72595041
27	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.67381751
28	TP53_22573176_ChIP-Seq_HFKS_Human	1.65821128
29	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.62261697
30	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.61637217
31	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.60197856
32	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.57779224
33	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.55975359
34	ER_23166858_ChIP-Seq_MCF-7_Human	1.53952180
35	P300_19829295_ChIP-Seq_ESCs_Human	1.53906051
36	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.52360470
37	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.50074749
38	IRF1_19129219_ChIP-ChIP_H3396_Human	1.40285631
39	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.39997973
40	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.39280937
41	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.39280937
42	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.38846994
43	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.37761837
44	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.37499147
45	FUS_26573619_Chip-Seq_HEK293_Human	1.35225647
46	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.32853321
47	EZH2_22144423_ChIP-Seq_EOC_Human	1.32543195
48	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.32147985
49	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.31802600
50	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.31615741
51	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.31609915
52	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.31583096
53	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.31403192
54	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.29220486
55	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.27558660
56	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.27299063
57	CBP_20019798_ChIP-Seq_JUKART_Human	1.26687823
58	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.26687823
59	NANOG_19829295_ChIP-Seq_ESCs_Human	1.26116747
60	SOX2_19829295_ChIP-Seq_ESCs_Human	1.26116747
61	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.22979477
62	GBX2_23144817_ChIP-Seq_PC3_Human	1.15060343
63	AR_20517297_ChIP-Seq_VCAP_Human	1.14974445
64	MYC_19829295_ChIP-Seq_ESCs_Human	1.13715775
65	GABP_19822575_ChIP-Seq_HepG2_Human	1.12838641
66	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.10911869
67	P300_18555785_Chip-Seq_ESCs_Mouse	1.07242129
68	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.07120843
69	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.05078791
70	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.04461232
71	CDX2_22108803_ChIP-Seq_LS180_Human	1.04460464
72	TAF15_26573619_Chip-Seq_HEK293_Human	1.04346817
73	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.02914190
74	GATA3_26560356_Chip-Seq_TH2_Human	1.02492697
75	TTF2_22483619_ChIP-Seq_HELA_Human	1.01897533
76	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01425976
77	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.00718906
78	RBPJ_21746931_ChIP-Seq_IB4_Human	1.00127310
79	PHF8_20622853_ChIP-Seq_HELA_Human	0.99113519
80	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.98612048
81	NANOG_20526341_ChIP-Seq_ESCs_Human	0.98054681
82	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.97314398
83	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96700016
84	RNF2_27304074_Chip-Seq_NSC_Mouse	0.96296959
85	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.96294315
86	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.96079198
87	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.96066046
88	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.95913340
89	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.95680227
90	P53_22387025_ChIP-Seq_ESCs_Mouse	0.94906318
91	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.94417172
92	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.94369763
93	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.94340589
94	TAF2_19829295_ChIP-Seq_ESCs_Human	0.93282545
95	BCAT_22108803_ChIP-Seq_LS180_Human	0.93221416
96	P53_21459846_ChIP-Seq_SAOS-2_Human	0.93164951
97	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.92261697
98	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.91830760
99	NCOR_22424771_ChIP-Seq_293T_Human	0.91624304
100	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.91024036

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	3.54783617
2	MP0008877_abnormal_DNA_methylation	3.35747609
3	MP0003195_calcinosis	3.02005147
4	MP0002163_abnormal_gland_morphology	2.70037148
5	MP0004885_abnormal_endolymph	2.62738061
6	MP0005671_abnormal_response_to	2.27881219
7	MP0002102_abnormal_ear_morphology	2.15703451
8	MP0003878_abnormal_ear_physiology	2.08112393
9	MP0005377_hearing/vestibular/ear_phenot	2.08112393
10	MP0002876_abnormal_thyroid_physiology	2.07442806
11	MP0002736_abnormal_nociception_after	2.02239523
12	MP0006072_abnormal_retinal_apoptosis	2.01808244
13	MP0005379_endocrine/exocrine_gland_phen	2.01726652
14	MP0003786_premature_aging	1.97787305
15	MP0004147_increased_porphyrin_level	1.96192570
16	MP0006276_abnormal_autonomic_nervous	1.94640482
17	MP0002837_dystrophic_cardiac_calcinosis	1.91233538
18	MP0005645_abnormal_hypothalamus_physiol	1.86726040
19	MP0005646_abnormal_pituitary_gland	1.83309173
20	MP0004742_abnormal_vestibular_system	1.83245996
21	MP0001984_abnormal_olfaction	1.70298603
22	MP0000372_irregular_coat_pigmentation	1.66834940
23	MP0006292_abnormal_olfactory_placode	1.66317768
24	MP0003693_abnormal_embryo_hatching	1.62061101
25	MP0008872_abnormal_physiological_respon	1.61009497
26	MP0002277_abnormal_respiratory_mucosa	1.58643896
27	MP0005551_abnormal_eye_electrophysiolog	1.57691351
28	MP0003122_maternal_imprinting	1.54344630
29	MP0001968_abnormal_touch/_nociception	1.53936126
30	MP0003567_abnormal_fetal_cardiomyocyte	1.53428035
31	MP0005084_abnormal_gallbladder_morpholo	1.51236823
32	MP0002138_abnormal_hepatobiliary_system	1.48862077
33	MP0002272_abnormal_nervous_system	1.44838956
34	MP0000685_abnormal_immune_system	1.40317288
35	MP0009745_abnormal_behavioral_response	1.40272411
36	MP0001485_abnormal_pinna_reflex	1.40223841
37	MP0005187_abnormal_penis_morphology	1.38919854
38	MP0004145_abnormal_muscle_electrophysio	1.38060365
39	MP0001790_abnormal_immune_system	1.37485051
40	MP0005387_immune_system_phenotype	1.37485051
41	MP0003806_abnormal_nucleotide_metabolis	1.36457304
42	MP0003121_genomic_imprinting	1.35951253
43	MP0008875_abnormal_xenobiotic_pharmacok	1.35589877
44	MP0002638_abnormal_pupillary_reflex	1.33328723
45	MP0001986_abnormal_taste_sensitivity	1.33302492
46	MP0000427_abnormal_hair_cycle	1.31550882
47	MP0005253_abnormal_eye_physiology	1.24853507
48	MP0009697_abnormal_copulation	1.24304583
49	MP0001501_abnormal_sleep_pattern	1.20123450
50	MP0001486_abnormal_startle_reflex	1.18856945
51	MP0003011_delayed_dark_adaptation	1.14512181
52	MP0004043_abnormal_pH_regulation	1.10551072
53	MP0005085_abnormal_gallbladder_physiolo	1.09993633
54	MP0002148_abnormal_hypersensitivity_rea	1.09331354
55	MP0004215_abnormal_myocardial_fiber	1.08273828
56	MP0008789_abnormal_olfactory_epithelium	1.02926632
57	MP0000230_abnormal_systemic_arterial	1.02768846
58	MP0004142_abnormal_muscle_tone	1.02610684
59	MP0001800_abnormal_humoral_immune	1.00898055
60	MP0003718_maternal_effect	1.00000939
61	MP0001188_hyperpigmentation	0.99799127
62	MP0003183_abnormal_peptide_metabolism	0.99534023
63	MP0006035_abnormal_mitochondrial_morpho	0.98935369
64	MP0001919_abnormal_reproductive_system	0.98548565
65	MP0008057_abnormal_DNA_replication	0.98016410
66	MP0003123_paternal_imprinting	0.96067001
67	MP0002095_abnormal_skin_pigmentation	0.93794254
68	MP0004133_heterotaxia	0.92754632
69	MP0002723_abnormal_immune_serum	0.88276319
70	MP0003283_abnormal_digestive_organ	0.87652828
71	MP0006036_abnormal_mitochondrial_physio	0.87266545
72	MP0000647_abnormal_sebaceous_gland	0.87013151
73	MP0009384_cardiac_valve_regurgitation	0.86916059
74	MP0009046_muscle_twitch	0.84105242
75	MP0005332_abnormal_amino_acid	0.84093375
76	MP0001529_abnormal_vocalization	0.82205461
77	MP0003252_abnormal_bile_duct	0.82201652
78	MP0009764_decreased_sensitivity_to	0.82075342
79	MP0001970_abnormal_pain_threshold	0.81891229
80	MP0001764_abnormal_homeostasis	0.81807271
81	MP0008058_abnormal_DNA_repair	0.81644848
82	MP0005389_reproductive_system_phenotype	0.80021530
83	MP0001905_abnormal_dopamine_level	0.79815367
84	MP0008775_abnormal_heart_ventricle	0.79124710
85	MP0002557_abnormal_social/conspecific_i	0.78712292
86	MP0001293_anophthalmia	0.78037202
87	MP0003866_abnormal_defecation	0.77823774
88	MP0009765_abnormal_xenobiotic_induced	0.77234115
89	MP0002693_abnormal_pancreas_physiology	0.76801222
90	MP0000631_abnormal_neuroendocrine_gland	0.76480199
91	MP0001502_abnormal_circadian_rhythm	0.75791841
92	MP0001929_abnormal_gametogenesis	0.74740660
93	MP0002928_abnormal_bile_duct	0.74147411
94	MP0002234_abnormal_pharynx_morphology	0.73949157
95	MP0005636_abnormal_mineral_homeostasis	0.73238321
96	MP0005410_abnormal_fertilization	0.72823264
97	MP0002733_abnormal_thermal_nociception	0.70965621
98	MP0001440_abnormal_grooming_behavior	0.68857678
99	MP0005367_renal/urinary_system_phenotyp	0.68821118
100	MP0000516_abnormal_urinary_system	0.68821118

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased hepatocellular lipid droplets (HP:0006565)	3.87008221
2	Acute necrotizing encephalopathy (HP:0006965)	3.74608151
3	Lipid accumulation in hepatocytes (HP:0006561)	3.65101354
4	Pancreatic cysts (HP:0001737)	3.62915394
5	Type II lissencephaly (HP:0007260)	3.55720569
6	Mitochondrial inheritance (HP:0001427)	3.45853462
7	Abnormality of the renal cortex (HP:0011035)	3.28688585
8	Progressive macrocephaly (HP:0004481)	3.27703867
9	Methylmalonic acidemia (HP:0002912)	3.25784167
10	Abnormal mitochondria in muscle tissue (HP:0008316)	3.23119568
11	Acute encephalopathy (HP:0006846)	3.21818060
12	Increased CSF lactate (HP:0002490)	3.21642990
13	Renal Fanconi syndrome (HP:0001994)	3.19921473
14	Renal cortical cysts (HP:0000803)	3.17128805
15	Abnormality of midbrain morphology (HP:0002418)	3.16090345
16	Molar tooth sign on MRI (HP:0002419)	3.16090345
17	Pancreatic fibrosis (HP:0100732)	3.12633965
18	IgG deficiency (HP:0004315)	3.05143648
19	Elevated erythrocyte sedimentation rate (HP:0003565)	3.04394542
20	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.03197232
21	Increased intramyocellular lipid droplets (HP:0012240)	2.96207943
22	Hyperglycinemia (HP:0002154)	2.94073888
23	True hermaphroditism (HP:0010459)	2.90863723
24	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.78809380
25	Nephronophthisis (HP:0000090)	2.71145161
26	Exertional dyspnea (HP:0002875)	2.68972487
27	3-Methylglutaconic aciduria (HP:0003535)	2.66422007
28	Congenital stationary night blindness (HP:0007642)	2.64811911
29	Methylmalonic aciduria (HP:0012120)	2.54963902
30	Abolished electroretinogram (ERG) (HP:0000550)	2.53611450
31	Abnormality of the labia minora (HP:0012880)	2.53348774
32	Congenital, generalized hypertrichosis (HP:0004540)	2.46245992
33	Cerebral edema (HP:0002181)	2.44001245
34	Medial flaring of the eyebrow (HP:0010747)	2.43431256
35	Abnormality of serine family amino acid metabolism (HP:0010894)	2.42117147
36	Abnormality of glycine metabolism (HP:0010895)	2.42117147
37	Increased muscle lipid content (HP:0009058)	2.41267244
38	Severe combined immunodeficiency (HP:0004430)	2.40119276
39	Pancytopenia (HP:0001876)	2.38807360
40	Attenuation of retinal blood vessels (HP:0007843)	2.35721247
41	Abnormality of the renal medulla (HP:0100957)	2.32949213
42	Entropion (HP:0000621)	2.30683509
43	Pendular nystagmus (HP:0012043)	2.29224043
44	Retinal dysplasia (HP:0007973)	2.26202549
45	Amyotrophic lateral sclerosis (HP:0007354)	2.23329810
46	Optic disc pallor (HP:0000543)	2.21450957
47	Arthropathy (HP:0003040)	2.19511174
48	Hepatic necrosis (HP:0002605)	2.18515145
49	Abnormal rod and cone electroretinograms (HP:0008323)	2.17632019
50	Hepatocellular necrosis (HP:0001404)	2.17243996
51	Thyroiditis (HP:0100646)	2.15742816
52	Hyperglycinuria (HP:0003108)	2.13775507
53	Abnormality of renal resorption (HP:0011038)	2.13319837
54	Glycosuria (HP:0003076)	2.10204274
55	Abnormality of urine glucose concentration (HP:0011016)	2.10204274
56	Stomatitis (HP:0010280)	2.09696374
57	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.06816319
58	Abnormal drinking behavior (HP:0030082)	2.01814640
59	Polydipsia (HP:0001959)	2.01814640
60	Abnormality of the anterior horn cell (HP:0006802)	2.01111196
61	Degeneration of anterior horn cells (HP:0002398)	2.01111196
62	Adrenal hypoplasia (HP:0000835)	2.00260121
63	Abnormality of DNA repair (HP:0003254)	1.99680738
64	Lissencephaly (HP:0001339)	1.99481913
65	Increased serum lactate (HP:0002151)	1.99034588
66	Tubular atrophy (HP:0000092)	1.98173079
67	Decreased central vision (HP:0007663)	1.95740797
68	Sclerocornea (HP:0000647)	1.94863373
69	Chronic hepatic failure (HP:0100626)	1.94213730
70	Congenital hepatic fibrosis (HP:0002612)	1.93868159
71	Increased IgM level (HP:0003496)	1.93836913
72	Colon cancer (HP:0003003)	1.93526849
73	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.92489136
74	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.92489136
75	Hyperphosphaturia (HP:0003109)	1.91933700
76	Lethargy (HP:0001254)	1.90106013
77	Lactic acidosis (HP:0003128)	1.84103234
78	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.82791026
79	Postaxial foot polydactyly (HP:0001830)	1.81877758
80	Anencephaly (HP:0002323)	1.81263430
81	Abnormality of eosinophils (HP:0001879)	1.78597616
82	Ketosis (HP:0001946)	1.78444832
83	Neutropenia (HP:0001875)	1.77390016
84	Inability to walk (HP:0002540)	1.77342848
85	Male pseudohermaphroditism (HP:0000037)	1.76664825
86	Cleft eyelid (HP:0000625)	1.75929940
87	Stenosis of the external auditory canal (HP:0000402)	1.75328895
88	Polyuria (HP:0000103)	1.74303131
89	Gait imbalance (HP:0002141)	1.73614108
90	Nephrogenic diabetes insipidus (HP:0009806)	1.73148832
91	Hypoproteinemia (HP:0003075)	1.72972571
92	Congenital primary aphakia (HP:0007707)	1.72546120
93	Progressive inability to walk (HP:0002505)	1.72160356
94	Conical tooth (HP:0000698)	1.70409538
95	Postaxial hand polydactyly (HP:0001162)	1.68615463
96	Leukodystrophy (HP:0002415)	1.68446375
97	Combined immunodeficiency (HP:0005387)	1.67414726
98	Exercise intolerance (HP:0003546)	1.65664240
99	Respiratory difficulties (HP:0002880)	1.65163350
100	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.64278491

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.70089847
2	TAOK3	3.36600818
3	NUAK1	2.93688137
4	BCR	2.88203753
5	FRK	2.78727647
6	ZAK	2.75087038
7	ADRBK2	2.55755408
8	MST4	2.29499072
9	WNK4	2.25526606
10	MAP4K1	2.22140223
11	PINK1	2.21523670
12	TAF1	2.16381036
13	NEK1	1.72453341
14	GRK1	1.69525525
15	TLK1	1.68253317
16	MAPK13	1.52149295
17	CDK19	1.48110768
18	OXSR1	1.46738558
19	MAP3K4	1.43290944
20	STK39	1.34619745
21	DYRK2	1.33745404
22	WNK3	1.30626060
23	SRPK1	1.29318669
24	VRK2	1.27144277
25	PAK3	1.26143900
26	FES	1.25271272
27	CSNK1G2	1.24570082
28	BUB1	1.24119646
29	NEK9	1.19368931
30	CSNK1A1L	1.16430918
31	CSNK1G3	1.13650731
32	EIF2AK3	1.13443304
33	BMPR1B	1.08071771
34	PLK2	1.07702382
35	PLK3	1.06076189
36	TNIK	1.05053114
37	TIE1	1.04995714
38	BCKDK	1.04687575
39	CDC7	1.02701258
40	TEC	1.02523723
41	CSNK1G1	1.01372536
42	GRK7	0.99415232
43	EIF2AK2	0.98403660
44	MAP2K7	0.97041877
45	KDR	0.96476520
46	TRIM28	0.96150961
47	MKNK2	0.94077951
48	VRK1	0.92855368
49	TSSK6	0.87709473
50	MATK	0.87554381
51	RPS6KA4	0.84257740
52	CASK	0.83508480
53	DAPK2	0.82782764
54	IKBKB	0.81500832
55	PLK4	0.80638981
56	ALK	0.79255592
57	PASK	0.78599276
58	PRKCQ	0.77841426
59	MAP4K2	0.77107812
60	ADRBK1	0.73430702
61	DYRK3	0.70880452
62	PRKCE	0.70527557
63	BMPR2	0.69214684
64	MAP2K6	0.69086620
65	MKNK1	0.68710692
66	STK16	0.67083470
67	PDK2	0.65972480
68	PRKCG	0.65325528
69	RPS6KA5	0.63676067
70	NME1	0.63336287
71	ITK	0.60124456
72	ATR	0.56567204
73	INSRR	0.55587448
74	PLK1	0.54983177
75	LIMK1	0.54508949
76	PRKCI	0.53510424
77	PHKG1	0.52660713
78	PHKG2	0.52660713
79	WEE1	0.52079789
80	SYK	0.50523863
81	MAPKAPK5	0.50276601
82	STK4	0.48454487
83	NTRK2	0.47851528
84	FGFR1	0.47808907
85	CSNK1A1	0.46736818
86	MINK1	0.46260555
87	CSNK2A2	0.42797305
88	EIF2AK1	0.42031264
89	CAMKK2	0.40284923
90	ERBB3	0.39118688
91	PRKACA	0.38291673
92	LCK	0.38080709
93	CHEK2	0.36892715
94	GRK5	0.35491066
95	EPHB2	0.34643784
96	AURKB	0.34421916
97	CAMK1	0.33784487
98	CSNK2A1	0.33538714
99	NTRK1	0.33010928
100	GRK6	0.32488947

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.70434187
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.52160239
3	Parkinsons disease_Homo sapiens_hsa05012	2.97938331
4	Proteasome_Homo sapiens_hsa03050	2.97598706
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.77033876
6	Primary immunodeficiency_Homo sapiens_hsa05340	2.31310112
7	RNA polymerase_Homo sapiens_hsa03020	2.17028198
8	Homologous recombination_Homo sapiens_hsa03440	2.14523814
9	Basal transcription factors_Homo sapiens_hsa03022	2.06478923
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.97789814
11	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.97274803
12	Phototransduction_Homo sapiens_hsa04744	1.83779786
13	One carbon pool by folate_Homo sapiens_hsa00670	1.82260794
14	Huntingtons disease_Homo sapiens_hsa05016	1.81895187
15	Caffeine metabolism_Homo sapiens_hsa00232	1.81117521
16	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.77359790
17	Alzheimers disease_Homo sapiens_hsa05010	1.72973653
18	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.72817437
19	RNA degradation_Homo sapiens_hsa03018	1.62813563
20	Sulfur metabolism_Homo sapiens_hsa00920	1.61534128
21	Butanoate metabolism_Homo sapiens_hsa00650	1.59852026
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.59379596
23	Mismatch repair_Homo sapiens_hsa03430	1.54855945
24	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.53191081
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.48078790
26	Fanconi anemia pathway_Homo sapiens_hsa03460	1.47385442
27	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.46823536
28	Collecting duct acid secretion_Homo sapiens_hsa04966	1.46734936
29	Selenocompound metabolism_Homo sapiens_hsa00450	1.46008635
30	Ribosome_Homo sapiens_hsa03010	1.45142629
31	Regulation of autophagy_Homo sapiens_hsa04140	1.42470418
32	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.39747165
33	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.34349160
34	Type I diabetes mellitus_Homo sapiens_hsa04940	1.32483280
35	Tryptophan metabolism_Homo sapiens_hsa00380	1.32089338
36	Nitrogen metabolism_Homo sapiens_hsa00910	1.26304893
37	Pyrimidine metabolism_Homo sapiens_hsa00240	1.26210647
38	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.25490809
39	Nucleotide excision repair_Homo sapiens_hsa03420	1.23334672
40	Propanoate metabolism_Homo sapiens_hsa00640	1.22895980
41	Cardiac muscle contraction_Homo sapiens_hsa04260	1.20624652
42	Olfactory transduction_Homo sapiens_hsa04740	1.20062485
43	Peroxisome_Homo sapiens_hsa04146	1.19102341
44	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.17687601
45	Graft-versus-host disease_Homo sapiens_hsa05332	1.10049806
46	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.10009912
47	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.09138484
48	DNA replication_Homo sapiens_hsa03030	1.07186397
49	Purine metabolism_Homo sapiens_hsa00230	0.99881982
50	RNA transport_Homo sapiens_hsa03013	0.99017294
51	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.96653891
52	Non-homologous end-joining_Homo sapiens_hsa03450	0.96413381
53	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.95911667
54	Allograft rejection_Homo sapiens_hsa05330	0.93647711
55	Nicotine addiction_Homo sapiens_hsa05033	0.92687382
56	Spliceosome_Homo sapiens_hsa03040	0.86904069
57	Asthma_Homo sapiens_hsa05310	0.86378408
58	Antigen processing and presentation_Homo sapiens_hsa04612	0.85862683
59	beta-Alanine metabolism_Homo sapiens_hsa00410	0.83657339
60	Ether lipid metabolism_Homo sapiens_hsa00565	0.82526247
61	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.81454495
62	Rheumatoid arthritis_Homo sapiens_hsa05323	0.79977728
63	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.77725955
64	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.72711890
65	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.69374694
66	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.68208801
67	Chemical carcinogenesis_Homo sapiens_hsa05204	0.66942392
68	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.64430902
69	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.63182102
70	Metabolic pathways_Homo sapiens_hsa01100	0.62580205
71	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.62373566
72	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.57690791
73	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.56113886
74	Morphine addiction_Homo sapiens_hsa05032	0.55693193
75	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.55552357
76	GABAergic synapse_Homo sapiens_hsa04727	0.54610873
77	Steroid biosynthesis_Homo sapiens_hsa00100	0.54268132
78	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.53890143
79	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.53190650
80	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.51901716
81	Retinol metabolism_Homo sapiens_hsa00830	0.49618741
82	ABC transporters_Homo sapiens_hsa02010	0.48383037
83	Fat digestion and absorption_Homo sapiens_hsa04975	0.47327596
84	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.44242044
85	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.43787004
86	Base excision repair_Homo sapiens_hsa03410	0.43248638
87	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.42431477
88	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.42101370
89	Glutathione metabolism_Homo sapiens_hsa00480	0.41492290
90	Taste transduction_Homo sapiens_hsa04742	0.37618824
91	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.35005954
92	Circadian rhythm_Homo sapiens_hsa04710	0.34164204
93	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.32360173
94	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.30981799
95	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.30269846
96	Pyruvate metabolism_Homo sapiens_hsa00620	0.29544214
97	mRNA surveillance pathway_Homo sapiens_hsa03015	0.29399807
98	Insulin secretion_Homo sapiens_hsa04911	0.28922050
99	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.27466711
100	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.26766148

BCLAF1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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