ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	8.02751746
2	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	6.11796655
3	behavioral response to nicotine (GO:0035095)	5.78016833
4	cytidine catabolic process (GO:0006216)	5.42195730
5	cytidine deamination (GO:0009972)	5.42195730
6	cytidine metabolic process (GO:0046087)	5.42195730
7	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	5.29817366
8	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	5.29817366
9	response to pheromone (GO:0019236)	5.03082734
10	respiratory chain complex IV assembly (GO:0008535)	4.93833571
11	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.52965431
12	water-soluble vitamin biosynthetic process (GO:0042364)	4.51060101
13	maturation of 5.8S rRNA (GO:0000460)	4.03493817
14	cytochrome complex assembly (GO:0017004)	3.99537958
15	signal peptide processing (GO:0006465)	3.87905537
16	protein polyglutamylation (GO:0018095)	3.72256725
17	negative regulation by host of viral transcription (GO:0043922)	3.70276363
18	positive regulation of prostaglandin secretion (GO:0032308)	3.69422771
19	protein neddylation (GO:0045116)	3.64168266
20	protein complex biogenesis (GO:0070271)	3.51296085
21	rRNA catabolic process (GO:0016075)	3.43094005
22	platelet dense granule organization (GO:0060155)	3.41221361
23	positive regulation of T cell differentiation in thymus (GO:0033089)	3.40916533
24	synaptic transmission, cholinergic (GO:0007271)	3.36750809
25	short-chain fatty acid metabolic process (GO:0046459)	3.34595259
26	mitochondrial respiratory chain complex assembly (GO:0033108)	3.34370515
27	regulation of action potential (GO:0098900)	3.33304064
28	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.31988487
29	NADH dehydrogenase complex assembly (GO:0010257)	3.31988487
30	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.31988487
31	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.31775371
32	kynurenine metabolic process (GO:0070189)	3.20519854
33	L-fucose catabolic process (GO:0042355)	3.16320518
34	fucose catabolic process (GO:0019317)	3.16320518
35	L-fucose metabolic process (GO:0042354)	3.16320518
36	kidney morphogenesis (GO:0060993)	3.16191552
37	regulation of mitochondrial translation (GO:0070129)	3.15838185
38	nonmotile primary cilium assembly (GO:0035058)	3.11579913
39	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.09331509
40	regulation of prostaglandin secretion (GO:0032306)	3.07920053
41	proline transport (GO:0015824)	3.06942768
42	auditory receptor cell differentiation (GO:0042491)	3.05395629
43	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.01774966
44	replication fork processing (GO:0031297)	3.00503473
45	axoneme assembly (GO:0035082)	2.95958129
46	tryptophan catabolic process (GO:0006569)	2.95363580
47	indole-containing compound catabolic process (GO:0042436)	2.95363580
48	indolalkylamine catabolic process (GO:0046218)	2.95363580
49	regulation of acrosome reaction (GO:0060046)	2.93798578
50	negative regulation of telomere maintenance (GO:0032205)	2.92596187
51	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.90225829
52	preassembly of GPI anchor in ER membrane (GO:0016254)	2.90029093
53	regulation of memory T cell differentiation (GO:0043380)	2.84777002
54	regulation of regulatory T cell differentiation (GO:0045589)	2.78782644
55	hypothalamus development (GO:0021854)	2.78025447
56	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.76201609
57	adaptation of signaling pathway (GO:0023058)	2.74775464
58	cellular ketone body metabolic process (GO:0046950)	2.72250069
59	DNA methylation involved in gamete generation (GO:0043046)	2.70739440
60	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.70276853
61	alanine transport (GO:0032328)	2.70122148
62	piRNA metabolic process (GO:0034587)	2.68345473
63	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.66240331
64	pyrimidine nucleoside catabolic process (GO:0046135)	2.63880248
65	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.61245894
66	positive regulation of synaptic transmission, GABAergic (GO:0032230)	2.58957795
67	nucleobase biosynthetic process (GO:0046112)	2.56063682
68	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.55511329
69	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.55337257
70	termination of RNA polymerase III transcription (GO:0006386)	2.55337257
71	serotonin metabolic process (GO:0042428)	2.54584877
72	NAD biosynthetic process (GO:0009435)	2.54574412
73	DNA demethylation (GO:0080111)	2.53738467
74	amino acid salvage (GO:0043102)	2.53668557
75	L-methionine salvage (GO:0071267)	2.53668557
76	L-methionine biosynthetic process (GO:0071265)	2.53668557
77	rRNA modification (GO:0000154)	2.52479520
78	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.51520063
79	ATP synthesis coupled proton transport (GO:0015986)	2.48962808
80	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.48962808
81	positive regulation of fatty acid transport (GO:2000193)	2.46748207
82	detection of light stimulus involved in visual perception (GO:0050908)	2.46360539
83	detection of light stimulus involved in sensory perception (GO:0050962)	2.46360539
84	spinal cord association neuron differentiation (GO:0021527)	2.45948808
85	glycine transport (GO:0015816)	2.45826285
86	indole-containing compound metabolic process (GO:0042430)	2.45279340
87	response to gravity (GO:0009629)	2.44362044
88	phenylpropanoid metabolic process (GO:0009698)	2.44106624
89	parturition (GO:0007567)	2.41910193
90	indolalkylamine metabolic process (GO:0006586)	2.40339733
91	regulation of cellular respiration (GO:0043457)	2.40063164
92	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.39999274
93	isotype switching (GO:0045190)	2.39999274
94	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.39999274
95	aggressive behavior (GO:0002118)	2.39130139
96	regulation of meiosis I (GO:0060631)	2.39078687
97	seminiferous tubule development (GO:0072520)	2.37886497
98	regulation of hexokinase activity (GO:1903299)	2.37299019
99	regulation of glucokinase activity (GO:0033131)	2.37299019
100	ketone body metabolic process (GO:1902224)	2.37281529

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.80037565
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.24816998
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.05842989
4	VDR_22108803_ChIP-Seq_LS180_Human	2.74009984
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.71242058
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.68098290
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.67829937
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.61388854
9	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.57152982
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.50212971
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.31248475
12	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.30031833
13	PCGF2_27294783_Chip-Seq_NPCs_Mouse	2.22573641
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.17482782
15	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.11880913
16	ER_23166858_ChIP-Seq_MCF-7_Human	2.02932846
17	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.97572519
18	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.93437586
19	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.88494162
20	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.83482842
21	P300_19829295_ChIP-Seq_ESCs_Human	1.80919349
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.78522021
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.76522034
24	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.75964474
25	TAF15_26573619_Chip-Seq_HEK293_Human	1.75649882
26	ELK1_19687146_ChIP-ChIP_HELA_Human	1.73837851
27	EWS_26573619_Chip-Seq_HEK293_Human	1.69868279
28	VDR_23849224_ChIP-Seq_CD4+_Human	1.67239110
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.66872397
30	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.64310614
31	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.63818617
32	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.62097062
33	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.61907248
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.60603244
35	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.59195038
36	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.57579861
37	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.52872331
38	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.50068466
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.50068466
40	FOXP3_21729870_ChIP-Seq_TREG_Human	1.49914042
41	NANOG_19829295_ChIP-Seq_ESCs_Human	1.47966598
42	SOX2_19829295_ChIP-Seq_ESCs_Human	1.47966598
43	FUS_26573619_Chip-Seq_HEK293_Human	1.47687329
44	BCAT_22108803_ChIP-Seq_LS180_Human	1.43300018
45	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.40589784
46	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.40589784
47	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.36179587
48	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.31676954
49	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.30267251
50	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.27625709
51	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.27262518
52	AR_20517297_ChIP-Seq_VCAP_Human	1.26685280
53	HOXB7_26014856_ChIP-Seq_BT474_Human	1.25213064
54	IRF1_19129219_ChIP-ChIP_H3396_Human	1.24089551
55	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.23097671
56	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.20920357
57	NCOR_22424771_ChIP-Seq_293T_Human	1.18622528
58	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.16717541
59	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.16415286
60	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.14335011
61	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.13633175
62	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.13531857
63	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.12586788
64	TCF4_23295773_ChIP-Seq_U87_Human	1.12097802
65	ERA_21632823_ChIP-Seq_H3396_Human	1.11018989
66	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.09780471
67	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.09550666
68	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.09447245
69	TAF2_19829295_ChIP-Seq_ESCs_Human	1.09404795
70	SMAD4_21799915_ChIP-Seq_A2780_Human	1.08695949
71	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.07600433
72	P53_22387025_ChIP-Seq_ESCs_Mouse	1.07355291
73	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.05264372
74	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.04894986
75	TCF4_22108803_ChIP-Seq_LS180_Human	1.04815795
76	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.04647014
77	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.04576566
78	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.04567189
79	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.04116679
80	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.03763011
81	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.03629839
82	P300_18555785_Chip-Seq_ESCs_Mouse	1.03582994
83	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.03495879
84	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.03435720
85	P53_21459846_ChIP-Seq_SAOS-2_Human	1.03374838
86	REST_21632747_ChIP-Seq_MESCs_Mouse	1.03175330
87	AR_25329375_ChIP-Seq_VCAP_Human	1.03021075
88	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.02597932
89	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.02543021
90	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.01246073
91	STAT3_23295773_ChIP-Seq_U87_Human	1.00901956
92	CTCF_18555785_Chip-Seq_ESCs_Mouse	1.00185500
93	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.99910422
94	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.99542383
95	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.97998688
96	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.97921740
97	RUNX2_22187159_ChIP-Seq_PCA_Human	0.97559811
98	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.97060900
99	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.96999470
100	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96879937

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005646_abnormal_pituitary_gland	3.96436983
2	MP0002163_abnormal_gland_morphology	3.67918119
3	MP0000372_irregular_coat_pigmentation	3.35698121
4	MP0008877_abnormal_DNA_methylation	2.46892107
5	MP0003011_delayed_dark_adaptation	2.43636121
6	MP0002837_dystrophic_cardiac_calcinosis	2.40984501
7	MP0005379_endocrine/exocrine_gland_phen	2.40910873
8	MP0005645_abnormal_hypothalamus_physiol	2.30152252
9	MP0005174_abnormal_tail_pigmentation	2.25700811
10	MP0005551_abnormal_eye_electrophysiolog	2.06915961
11	MP0002735_abnormal_chemical_nociception	1.97023875
12	MP0003787_abnormal_imprinting	1.92874929
13	MP0001529_abnormal_vocalization	1.90230272
14	MP0005075_abnormal_melanosome_morpholog	1.87937353
15	MP0001968_abnormal_touch/_nociception	1.85218891
16	MP0005671_abnormal_response_to	1.83718465
17	MP0000569_abnormal_digit_pigmentation	1.81302708
18	MP0002638_abnormal_pupillary_reflex	1.77235515
19	MP0006072_abnormal_retinal_apoptosis	1.76764214
20	MP0004147_increased_porphyrin_level	1.69835863
21	MP0002277_abnormal_respiratory_mucosa	1.68267170
22	MP0002138_abnormal_hepatobiliary_system	1.67240763
23	MP0003786_premature_aging	1.67107019
24	MP0003283_abnormal_digestive_organ	1.61595274
25	MP0003646_muscle_fatigue	1.59876629
26	MP0000631_abnormal_neuroendocrine_gland	1.55674713
27	MP0005253_abnormal_eye_physiology	1.54055506
28	MP0006292_abnormal_olfactory_placode	1.50948899
29	MP0002095_abnormal_skin_pigmentation	1.48850234
30	MP0006054_spinal_hemorrhage	1.47894366
31	MP0003718_maternal_effect	1.47009457
32	MP0005670_abnormal_white_adipose	1.46613028
33	MP0002736_abnormal_nociception_after	1.44907140
34	MP0001501_abnormal_sleep_pattern	1.39726100
35	MP0000015_abnormal_ear_pigmentation	1.38542309
36	MP0005084_abnormal_gallbladder_morpholo	1.38305061
37	MP0001486_abnormal_startle_reflex	1.34426259
38	MP0000013_abnormal_adipose_tissue	1.34285374
39	MP0002102_abnormal_ear_morphology	1.31314635
40	MP0001440_abnormal_grooming_behavior	1.30338215
41	MP0003136_yellow_coat_color	1.29573166
42	MP0009745_abnormal_behavioral_response	1.29167790
43	MP0008872_abnormal_physiological_respon	1.27125518
44	MP0001986_abnormal_taste_sensitivity	1.26505913
45	MP0008789_abnormal_olfactory_epithelium	1.24431247
46	MP0002876_abnormal_thyroid_physiology	1.24397707
47	MP0002938_white_spotting	1.23573467
48	MP0004043_abnormal_pH_regulation	1.22181774
49	MP0010386_abnormal_urinary_bladder	1.18888683
50	MP0005410_abnormal_fertilization	1.18304393
51	MP0001485_abnormal_pinna_reflex	1.18257990
52	MP0005220_abnormal_exocrine_pancreas	1.16431804
53	MP0001764_abnormal_homeostasis	1.16111171
54	MP0002557_abnormal_social/conspecific_i	1.15971416
55	MP0003195_calcinosis	1.15193071
56	MP0009046_muscle_twitch	1.15136898
57	MP0002733_abnormal_thermal_nociception	1.14641985
58	MP0001970_abnormal_pain_threshold	1.14293459
59	MP0001661_extended_life_span	1.11475606
60	MP0004885_abnormal_endolymph	1.11149328
61	MP0004142_abnormal_muscle_tone	1.09785751
62	MP0002272_abnormal_nervous_system	1.06138020
63	MP0001919_abnormal_reproductive_system	1.04049726
64	MP0004742_abnormal_vestibular_system	1.03637714
65	MP0008961_abnormal_basal_metabolism	1.02307054
66	MP0002693_abnormal_pancreas_physiology	1.01187296
67	MP0002572_abnormal_emotion/affect_behav	1.00913393
68	MP0002822_catalepsy	0.99219038
69	MP0005389_reproductive_system_phenotype	0.99198468
70	MP0004133_heterotaxia	0.98811026
71	MP0001944_abnormal_pancreas_morphology	0.91551586
72	MP0008058_abnormal_DNA_repair	0.90618708
73	MP0009780_abnormal_chondrocyte_physiolo	0.90417514
74	MP0005636_abnormal_mineral_homeostasis	0.87446840
75	MP0000427_abnormal_hair_cycle	0.87437781
76	MP0000230_abnormal_systemic_arterial	0.86594146
77	MP0003950_abnormal_plasma_membrane	0.86239689
78	MP0001293_anophthalmia	0.85544139
79	MP0002064_seizures	0.83770773
80	MP0001835_abnormal_antigen_presentation	0.83404689
81	MP0004145_abnormal_muscle_electrophysio	0.81358605
82	MP0003635_abnormal_synaptic_transmissio	0.81293097
83	MP0002734_abnormal_mechanical_nocicepti	0.80938950
84	MP0003943_abnormal_hepatobiliary_system	0.80142784
85	MP0002067_abnormal_sensory_capabilities	0.78020878
86	MP0008057_abnormal_DNA_replication	0.77978399
87	MP0005332_abnormal_amino_acid	0.75095907
88	MP0006036_abnormal_mitochondrial_physio	0.73428360
89	MP0002160_abnormal_reproductive_system	0.73400450
90	MP0001984_abnormal_olfaction	0.73213155
91	MP0003183_abnormal_peptide_metabolism	0.73167419
92	MP0009697_abnormal_copulation	0.72910072
93	MP0002063_abnormal_learning/memory/cond	0.71870891
94	MP0002909_abnormal_adrenal_gland	0.71585490
95	MP0001963_abnormal_hearing_physiology	0.71379028
96	MP0000371_diluted_coat_color	0.70126388
97	MP0003806_abnormal_nucleotide_metabolis	0.69988011
98	MP0005195_abnormal_posterior_eye	0.69151845
99	MP0005360_urolithiasis	0.68932376
100	MP0004215_abnormal_myocardial_fiber	0.68651351

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic fibrosis (HP:0100732)	3.77721962
2	Methylmalonic acidemia (HP:0002912)	3.64857116
3	Pancreatic cysts (HP:0001737)	3.48379389
4	Mitochondrial inheritance (HP:0001427)	3.40520448
5	Acute necrotizing encephalopathy (HP:0006965)	3.31724359
6	Abnormality of the renal cortex (HP:0011035)	3.20303396
7	Aplasia/Hypoplasia of the fovea (HP:0008060)	3.12588281
8	Hypoplasia of the fovea (HP:0007750)	3.12588281
9	Nephronophthisis (HP:0000090)	3.12021800
10	Methylmalonic aciduria (HP:0012120)	3.10132063
11	Medial flaring of the eyebrow (HP:0010747)	3.03555290
12	Abnormality of midbrain morphology (HP:0002418)	3.01916480
13	Molar tooth sign on MRI (HP:0002419)	3.01916480
14	Acute encephalopathy (HP:0006846)	3.00307072
15	Congenital stationary night blindness (HP:0007642)	2.95993377
16	Lipid accumulation in hepatocytes (HP:0006561)	2.94850756
17	Increased hepatocellular lipid droplets (HP:0006565)	2.94544469
18	True hermaphroditism (HP:0010459)	2.90629524
19	Progressive macrocephaly (HP:0004481)	2.90239024
20	Abnormal mitochondria in muscle tissue (HP:0008316)	2.86871057
21	Type II lissencephaly (HP:0007260)	2.86646934
22	Increased CSF lactate (HP:0002490)	2.85792196
23	Hyperglycinemia (HP:0002154)	2.74015253
24	Renal cortical cysts (HP:0000803)	2.70842944
25	Abnormality of the fovea (HP:0000493)	2.66146384
26	Severe visual impairment (HP:0001141)	2.64789364
27	Hyperglycinuria (HP:0003108)	2.64062798
28	Large for gestational age (HP:0001520)	2.62858859
29	Abnormality of glycine metabolism (HP:0010895)	2.61080708
30	Abnormality of serine family amino acid metabolism (HP:0010894)	2.61080708
31	Abnormality of the renal medulla (HP:0100957)	2.60593375
32	Renal Fanconi syndrome (HP:0001994)	2.58228406
33	Hepatocellular necrosis (HP:0001404)	2.53046805
34	Pendular nystagmus (HP:0012043)	2.47620329
35	Attenuation of retinal blood vessels (HP:0007843)	2.46323281
36	Gait imbalance (HP:0002141)	2.44434817
37	Thyroiditis (HP:0100646)	2.42300918
38	Aplastic anemia (HP:0001915)	2.39058996
39	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.34738988
40	Abnormality of vitamin B metabolism (HP:0004340)	2.32726205
41	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.30507889
42	Absent/shortened dynein arms (HP:0200106)	2.30507889
43	Severe combined immunodeficiency (HP:0004430)	2.27963865
44	Congenital primary aphakia (HP:0007707)	2.27329961
45	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.25273958
46	Dyskinesia (HP:0100660)	2.24226339
47	Abnormality of the pons (HP:0007361)	2.23571151
48	Increased corneal curvature (HP:0100692)	2.21673140
49	Keratoconus (HP:0000563)	2.21673140
50	Hepatic necrosis (HP:0002605)	2.21013097
51	Ketoacidosis (HP:0001993)	2.21004276
52	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.14286190
53	Ketosis (HP:0001946)	2.13634200
54	Sclerocornea (HP:0000647)	2.11484390
55	Increased intramyocellular lipid droplets (HP:0012240)	2.11112436
56	Postaxial foot polydactyly (HP:0001830)	2.10112938
57	Cerebral palsy (HP:0100021)	2.09755829
58	IgG deficiency (HP:0004315)	2.08459166
59	Increased serum lactate (HP:0002151)	2.07934704
60	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.05968480
61	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.04985407
62	Abnormality of the ileum (HP:0001549)	2.03045034
63	Meckel diverticulum (HP:0002245)	2.02016109
64	Abnormality of the carotid arteries (HP:0005344)	1.97459788
65	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.95699569
66	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.95699569
67	Cystic liver disease (HP:0006706)	1.94070317
68	Cerebral edema (HP:0002181)	1.93553672
69	Chronic hepatic failure (HP:0100626)	1.93337536
70	Inability to walk (HP:0002540)	1.92756735
71	Hypoproteinemia (HP:0003075)	1.90449144
72	Fair hair (HP:0002286)	1.89973507
73	Optic disc pallor (HP:0000543)	1.88444382
74	Hypoplasia of the pons (HP:0012110)	1.88070776
75	Abnormality of renal resorption (HP:0011038)	1.86681888
76	Abnormal drinking behavior (HP:0030082)	1.86472099
77	Polydipsia (HP:0001959)	1.86472099
78	Albinism (HP:0001022)	1.85099585
79	Abnormality of DNA repair (HP:0003254)	1.84884822
80	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.82350606
81	Aplasia/Hypoplasia of the macula (HP:0008059)	1.82050029
82	Hemiparesis (HP:0001269)	1.81816630
83	Increased muscle lipid content (HP:0009058)	1.81448635
84	Hydroxyprolinuria (HP:0003080)	1.79655649
85	Abnormality of proline metabolism (HP:0010907)	1.79655649
86	Nephrogenic diabetes insipidus (HP:0009806)	1.78150020
87	Genetic anticipation (HP:0003743)	1.77943338
88	Asplenia (HP:0001746)	1.77570605
89	Progressive inability to walk (HP:0002505)	1.76689944
90	Congenital sensorineural hearing impairment (HP:0008527)	1.76446558
91	Exertional dyspnea (HP:0002875)	1.74670962
92	Congenital, generalized hypertrichosis (HP:0004540)	1.74413039
93	Abolished electroretinogram (ERG) (HP:0000550)	1.74286865
94	Gout (HP:0001997)	1.73394024
95	Abnormality of alanine metabolism (HP:0010916)	1.73297844
96	Hyperalaninemia (HP:0003348)	1.73297844
97	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.73297844
98	Abnormal rod and cone electroretinograms (HP:0008323)	1.72197791
99	Lethargy (HP:0001254)	1.72113083
100	Furrowed tongue (HP:0000221)	1.72102848

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.48524857
2	TXK	4.18164497
3	TAOK3	3.69127838
4	BMPR1B	2.99824133
5	FRK	2.94510499
6	NUAK1	2.87753349
7	VRK2	2.54641459
8	EIF2AK3	2.44646007
9	DAPK2	2.43135717
10	PRKD3	2.23161919
11	ZAK	2.18605827
12	MAP4K1	2.07014063
13	KDR	2.06780255
14	MST4	1.96996170
15	ADRBK2	1.78065535
16	TLK1	1.76563154
17	DYRK3	1.73367080
18	GRK1	1.68243324
19	DYRK2	1.64101502
20	MAPK13	1.43109152
21	WNK3	1.39769276
22	BCKDK	1.36008102
23	LIMK1	1.35447321
24	EIF2AK2	1.31044315
25	CASK	1.29464313
26	VRK1	1.23356719
27	OXSR1	1.17459223
28	STK39	1.14627630
29	INSRR	1.13770883
30	CDK19	1.11572667
31	PRKCQ	1.09740019
32	PAK3	1.00731142
33	WNK4	0.98306454
34	ERBB3	0.97318245
35	TIE1	0.94699972
36	PRKCH	0.94090110
37	MKNK2	0.92364355
38	DYRK1B	0.91058113
39	MAP2K7	0.90608817
40	TAF1	0.89868259
41	ACVR1B	0.86462868
42	PRKCE	0.85266233
43	EPHA4	0.84045093
44	PRKCG	0.83302027
45	SYK	0.79649072
46	PNCK	0.77841308
47	PRKD2	0.76470876
48	MAP3K4	0.72751850
49	CAMKK2	0.71813126
50	PHKG1	0.71669317
51	PHKG2	0.71669317
52	PLK3	0.71280375
53	PLK4	0.71216986
54	GRK7	0.69885248
55	ADRBK1	0.68974523
56	ITK	0.68513922
57	WNK1	0.66383894
58	PDK2	0.62931572
59	GRK5	0.60843721
60	TEC	0.59360050
61	IRAK1	0.57725206
62	STK10	0.57219551
63	NTRK2	0.57139066
64	PKN1	0.56567858
65	MAP3K11	0.55619152
66	KIT	0.54373583
67	TRPM7	0.54301633
68	CSNK1G2	0.53452459
69	ROCK1	0.52680276
70	MARK1	0.51432819
71	RPS6KB1	0.50639375
72	RAF1	0.48959702
73	ATR	0.47262563
74	PRKACB	0.46961405
75	DAPK1	0.46217297
76	MAP3K12	0.46186516
77	CSF1R	0.45493959
78	CSNK1G1	0.43181033
79	IKBKB	0.41725815
80	PRKACA	0.40640076
81	PRKCI	0.40164143
82	NTRK3	0.38960113
83	TRIM28	0.38206986
84	DYRK1A	0.37817364
85	MUSK	0.37283523
86	CHEK2	0.35494493
87	STK16	0.34516398
88	CSNK2A2	0.33999260
89	PLK1	0.33905124
90	CSNK2A1	0.33692241
91	TSSK6	0.33446715
92	PRKCZ	0.33292187
93	TGFBR1	0.33239777
94	TNK2	0.32727655
95	CSNK1E	0.32511228
96	MAP3K9	0.31972026
97	LYN	0.31146485
98	MAP2K6	0.30520403
99	PIK3CA	0.29450377
100	PRKCA	0.28565293

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	2.73478022
2	Butanoate metabolism_Homo sapiens_hsa00650	2.57529040
3	Propanoate metabolism_Homo sapiens_hsa00640	2.43163248
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.41253866
5	RNA polymerase_Homo sapiens_hsa03020	2.31325881
6	Protein export_Homo sapiens_hsa03060	2.25632220
7	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.22922715
8	Phototransduction_Homo sapiens_hsa04744	2.18623758
9	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.12040371
10	Proteasome_Homo sapiens_hsa03050	2.10852282
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.10509079
12	Parkinsons disease_Homo sapiens_hsa05012	2.06839207
13	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.92440464
14	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.90926958
15	Nicotine addiction_Homo sapiens_hsa05033	1.90186713
16	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.90122631
17	RNA degradation_Homo sapiens_hsa03018	1.89646071
18	Basal transcription factors_Homo sapiens_hsa03022	1.78687592
19	Primary immunodeficiency_Homo sapiens_hsa05340	1.74340780
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.68427519
21	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.63949683
22	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.62884482
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.61680979
24	Huntingtons disease_Homo sapiens_hsa05016	1.57948350
25	Alzheimers disease_Homo sapiens_hsa05010	1.50985424
26	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.43716684
27	Homologous recombination_Homo sapiens_hsa03440	1.41579649
28	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.40354092
29	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.39028739
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.38255162
31	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.36811662
32	Selenocompound metabolism_Homo sapiens_hsa00450	1.35349148
33	Pyrimidine metabolism_Homo sapiens_hsa00240	1.33598632
34	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.32940843
35	beta-Alanine metabolism_Homo sapiens_hsa00410	1.32662506
36	Olfactory transduction_Homo sapiens_hsa04740	1.32196344
37	Fanconi anemia pathway_Homo sapiens_hsa03460	1.25759500
38	Regulation of autophagy_Homo sapiens_hsa04140	1.17482667
39	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.17238033
40	Nitrogen metabolism_Homo sapiens_hsa00910	1.16222999
41	Morphine addiction_Homo sapiens_hsa05032	1.15593645
42	Cardiac muscle contraction_Homo sapiens_hsa04260	1.11587862
43	Purine metabolism_Homo sapiens_hsa00230	1.05309954
44	Ether lipid metabolism_Homo sapiens_hsa00565	1.04963295
45	Peroxisome_Homo sapiens_hsa04146	1.02615752
46	Nucleotide excision repair_Homo sapiens_hsa03420	1.01790885
47	Antigen processing and presentation_Homo sapiens_hsa04612	0.98833493
48	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.98172011
49	Ribosome_Homo sapiens_hsa03010	0.97954783
50	Retinol metabolism_Homo sapiens_hsa00830	0.97197091
51	Spliceosome_Homo sapiens_hsa03040	0.96815806
52	One carbon pool by folate_Homo sapiens_hsa00670	0.96513950
53	Fat digestion and absorption_Homo sapiens_hsa04975	0.96392838
54	GABAergic synapse_Homo sapiens_hsa04727	0.95945925
55	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.94583454
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.88407065
57	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.87450650
58	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.85354795
59	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.84317124
60	Chemical carcinogenesis_Homo sapiens_hsa05204	0.84055092
61	Type I diabetes mellitus_Homo sapiens_hsa04940	0.83655645
62	ABC transporters_Homo sapiens_hsa02010	0.81027870
63	Taste transduction_Homo sapiens_hsa04742	0.80317729
64	Sulfur metabolism_Homo sapiens_hsa00920	0.79733340
65	Insulin secretion_Homo sapiens_hsa04911	0.78755478
66	Glycerolipid metabolism_Homo sapiens_hsa00561	0.76128364
67	Fatty acid degradation_Homo sapiens_hsa00071	0.75126949
68	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.74429782
69	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.74219501
70	RNA transport_Homo sapiens_hsa03013	0.73969073
71	DNA replication_Homo sapiens_hsa03030	0.73843331
72	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.73617334
73	Renin-angiotensin system_Homo sapiens_hsa04614	0.73475960
74	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.69596291
75	Metabolic pathways_Homo sapiens_hsa01100	0.69334502
76	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.68742763
77	Graft-versus-host disease_Homo sapiens_hsa05332	0.67457754
78	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.66831711
79	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.63588063
80	Non-homologous end-joining_Homo sapiens_hsa03450	0.62956558
81	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.61184439
82	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.60692805
83	Salivary secretion_Homo sapiens_hsa04970	0.60093280
84	Asthma_Homo sapiens_hsa05310	0.59536437
85	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.59357757
86	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.58787518
87	Pyruvate metabolism_Homo sapiens_hsa00620	0.56266525
88	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.55675947
89	Mineral absorption_Homo sapiens_hsa04978	0.54667093
90	Pancreatic secretion_Homo sapiens_hsa04972	0.50150763
91	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.45677595
92	Circadian entrainment_Homo sapiens_hsa04713	0.41154861
93	Caffeine metabolism_Homo sapiens_hsa00232	0.39015798
94	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.38766704
95	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.37936767
96	Fatty acid metabolism_Homo sapiens_hsa01212	0.37791258
97	Mismatch repair_Homo sapiens_hsa03430	0.37054645
98	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.36515540
99	Calcium signaling pathway_Homo sapiens_hsa04020	0.36067235
100	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.36023404

BCLAF1P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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