BCOR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.68668102
2regulation of NFAT protein import into nucleus (GO:0051532)4.61716581
3mitotic sister chromatid segregation (GO:0000070)4.61666458
4DNA replication initiation (GO:0006270)4.51657744
5DNA replication checkpoint (GO:0000076)4.27826219
6spliceosomal tri-snRNP complex assembly (GO:0000244)4.20426467
7nuclear pore complex assembly (GO:0051292)4.19247386
8DNA strand elongation involved in DNA replication (GO:0006271)4.09519161
9regulation of gamma-delta T cell differentiation (GO:0045586)4.03421519
10DNA strand elongation (GO:0022616)3.96867500
11regulation of nucleobase-containing compound transport (GO:0032239)3.88177050
12nuclear pore organization (GO:0006999)3.79923584
13positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.79302341
14regulation of gamma-delta T cell activation (GO:0046643)3.77083981
15DNA synthesis involved in DNA repair (GO:0000731)3.67217119
16regulation of interleukin-12 biosynthetic process (GO:0045075)3.63897939
17antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.59678507
18antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.59678507
19regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.58373024
20DNA unwinding involved in DNA replication (GO:0006268)3.55031113
21regulation of DNA damage checkpoint (GO:2000001)3.50638509
22antigen processing and presentation of endogenous antigen (GO:0019883)3.46587175
23positive thymic T cell selection (GO:0045059)3.46445273
24DNA conformation change (GO:0071103)3.43580530
25cellular protein complex localization (GO:0034629)3.40972760
26* regulation of histone H3-K4 methylation (GO:0051569)3.38540814
27positive regulation of histone deacetylation (GO:0031065)3.38363305
28chromosome condensation (GO:0030261)3.37988048
29pore complex assembly (GO:0046931)3.36545686
30positive regulation by host of viral transcription (GO:0043923)3.35672234
31dosage compensation (GO:0007549)3.33044654
32protein complex localization (GO:0031503)3.32223364
33* regulation of histone methylation (GO:0031060)3.30881366
34telomere maintenance via semi-conservative replication (GO:0032201)3.26880604
35positive regulation of cell cycle checkpoint (GO:1901978)3.24925072
36regulation of histone H3-K27 methylation (GO:0061085)3.23135100
37nuclear envelope organization (GO:0006998)3.22070198
38protein localization to kinetochore (GO:0034501)3.19820275
39mitotic sister chromatid cohesion (GO:0007064)3.18372420
40mRNA transport (GO:0051028)3.18054716
41DNA packaging (GO:0006323)3.17410371
42positive regulation of chromosome segregation (GO:0051984)3.12803501
43pre-miRNA processing (GO:0031054)3.12070111
44histone H4-K16 acetylation (GO:0043984)3.11826051
45sister chromatid cohesion (GO:0007062)3.10093385
463-UTR-mediated mRNA stabilization (GO:0070935)3.08542192
47regulation of sister chromatid cohesion (GO:0007063)3.07529352
48glucocorticoid receptor signaling pathway (GO:0042921)3.05869293
49positive regulation of B cell differentiation (GO:0045579)3.04901966
50histone lysine methylation (GO:0034968)3.01747019
51histone H3-K36 demethylation (GO:0070544)3.01301116
52mRNA stabilization (GO:0048255)2.99693745
53RNA stabilization (GO:0043489)2.99693745
54regulation of mammary gland epithelial cell proliferation (GO:0033599)2.97415118
55positive regulation of DNA-dependent DNA replication (GO:2000105)2.97157717
56meiotic chromosome segregation (GO:0045132)2.96212661
57mitotic nuclear envelope disassembly (GO:0007077)2.95404014
58negative regulation of RNA splicing (GO:0033119)2.95231757
59transcription from mitochondrial promoter (GO:0006390)2.95180315
60ribosomal small subunit assembly (GO:0000028)2.95078950
61* negative regulation of histone methylation (GO:0031061)2.93948207
62negative T cell selection (GO:0043383)2.93687654
63histone methylation (GO:0016571)2.93039096
64mRNA export from nucleus (GO:0006406)2.92807502
65negative thymic T cell selection (GO:0045060)2.92395245
66alternative mRNA splicing, via spliceosome (GO:0000380)2.90414441
67telomere maintenance via recombination (GO:0000722)2.88851066
68histone H4-K5 acetylation (GO:0043981)2.87921375
69histone H4-K8 acetylation (GO:0043982)2.87921375
70regulation of DNA-dependent DNA replication (GO:0090329)2.87135711
71positive regulation of RNA splicing (GO:0033120)2.86988307
72positive regulation of isotype switching (GO:0045830)2.86150528
73regulation of histone H3-K9 methylation (GO:0051570)2.85246026
74negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.84736156
75monoubiquitinated protein deubiquitination (GO:0035520)2.84617455
76V(D)J recombination (GO:0033151)2.84367632
77positive T cell selection (GO:0043368)2.83873554
78thymic T cell selection (GO:0045061)2.83632076
79corticosteroid receptor signaling pathway (GO:0031958)2.82833262
80RNA transport (GO:0050658)2.81164089
81establishment of RNA localization (GO:0051236)2.81164089
82nucleic acid transport (GO:0050657)2.81164089
83RNA export from nucleus (GO:0006405)2.80927158
84NIK/NF-kappaB signaling (GO:0038061)2.80337591
85protein export from nucleus (GO:0006611)2.79920676
86mitotic recombination (GO:0006312)2.78339316
87negative regulation of DNA repair (GO:0045738)2.78186002
88regulation of cell cycle checkpoint (GO:1901976)2.75798488
89positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.74583026
90mRNA splice site selection (GO:0006376)2.74184841
91membrane disassembly (GO:0030397)2.74066846
92nuclear envelope disassembly (GO:0051081)2.74066846
93intracellular estrogen receptor signaling pathway (GO:0030520)2.73987639
94folic acid metabolic process (GO:0046655)2.73386301
95regulation of centrosome cycle (GO:0046605)2.72470261
96histone H2B ubiquitination (GO:0033523)2.72019398
97antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.70012653
98T cell selection (GO:0045058)2.69526976
99regulation of RNA export from nucleus (GO:0046831)2.69144832
100positive regulation of protein deacetylation (GO:0090312)2.69102542
101nucleosome disassembly (GO:0006337)2.67185441
102protein-DNA complex disassembly (GO:0032986)2.67185441
103T cell apoptotic process (GO:0070231)2.67137098
104DNA duplex unwinding (GO:0032508)2.66731335
105leukocyte aggregation (GO:0070486)2.65936488
106tolerance induction (GO:0002507)2.63691957
107folic acid-containing compound biosynthetic process (GO:0009396)2.61651828
108DNA geometric change (GO:0032392)2.60823748
109negative regulation of erythrocyte differentiation (GO:0045647)2.60118304
110regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.58610405
111JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.58248733
112protein localization to chromosome, centromeric region (GO:0071459)2.57966214
113hepatocyte apoptotic process (GO:0097284)2.57100427
114heterochromatin organization (GO:0070828)2.55180789
115T cell homeostasis (GO:0043029)2.53333789
116cytoplasmic mRNA processing body assembly (GO:0033962)2.53068649
117regulation of B cell differentiation (GO:0045577)2.50391732
118trophectodermal cell differentiation (GO:0001829)2.50268746
119B cell receptor signaling pathway (GO:0050853)2.48916245
120viral transcription (GO:0019083)2.48177416
121regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.46741273
122definitive hemopoiesis (GO:0060216)2.46653329
123regulation of mRNA stability (GO:0043488)2.45852910
124IMP biosynthetic process (GO:0006188)2.45640628
125negative regulation of cell killing (GO:0031342)2.45015056
126negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.45015056
127natural killer cell differentiation (GO:0001779)2.43605826
128chromatin assembly (GO:0031497)2.43468334
129mitotic chromosome condensation (GO:0007076)2.42752966
130positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.41538804
131embryonic hemopoiesis (GO:0035162)2.41332977
132DNA topological change (GO:0006265)2.40331150
133positive regulation of gene expression, epigenetic (GO:0045815)2.39130723
134negative regulation of phagocytosis (GO:0050765)2.38475918
135CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.38384320
136regulation of RNA stability (GO:0043487)2.35675586
137translational termination (GO:0006415)2.34299255
138interferon-gamma production (GO:0032609)2.33938209
139sister chromatid segregation (GO:0000819)2.32978216
140nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.31195608
141regulation of chromatin binding (GO:0035561)2.30311318
142response to interleukin-15 (GO:0070672)2.30251775
143NLS-bearing protein import into nucleus (GO:0006607)2.29944392
144regulation of erythrocyte differentiation (GO:0045646)2.29656215
145histone H3-K4 methylation (GO:0051568)2.28728840
146translesion synthesis (GO:0019985)2.28533524
147regulation of translational fidelity (GO:0006450)2.28328140
148lymphocyte homeostasis (GO:0002260)2.27964645
149formation of translation preinitiation complex (GO:0001731)2.27684056
150regulation of DNA endoreduplication (GO:0032875)2.26786380
151negative regulation of mRNA processing (GO:0050686)2.26684638
152negative regulation of mRNA metabolic process (GO:1903312)2.26473175
153positive regulation of transcription regulatory region DNA binding (GO:2000679)2.25937110
154endothelial tube morphogenesis (GO:0061154)2.25556824
155morphogenesis of an endothelium (GO:0003159)2.25556824
156negative regulation of gene expression, epigenetic (GO:0045814)2.25453090
157positive regulation of B cell mediated immunity (GO:0002714)2.23869540

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.46189153
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.37592072
3* MYC_22102868_ChIP-Seq_BL_Human4.12193638
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.76452100
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.21655046
6* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.99295948
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.94411415
8VDR_21846776_ChIP-Seq_THP-1_Human2.91088016
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.86927372
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.56222844
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.44048565
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.40095137
13* TCF7_22412390_ChIP-Seq_EML_Mouse2.31571465
14YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.24277207
15* MAF_26560356_Chip-Seq_TH1_Human2.19320186
16SCL_19346495_ChIP-Seq_HPC-7_Human2.19002052
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.16047204
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.10811246
19POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.07631385
20UTX_26944678_Chip-Seq_JUKART_Human2.06217172
21TP63_19390658_ChIP-ChIP_HaCaT_Human2.04882617
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.04694406
23IRF8_22096565_ChIP-ChIP_GC-B_Human2.02176625
24ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.01191805
25MYC_18555785_ChIP-Seq_MESCs_Mouse2.00311573
26CIITA_25753668_ChIP-Seq_RAJI_Human1.98738162
27* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.95355952
28* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.90581359
29* MYB_26560356_Chip-Seq_TH2_Human1.88730140
30* KDM2B_26808549_Chip-Seq_DND41_Human1.88696608
31MYB_26560356_Chip-Seq_TH1_Human1.83642663
32* VDR_24763502_ChIP-Seq_THP-1_Human1.80821630
33* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.80771890
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.77331027
35* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.75353397
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74181937
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.72229420
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.70955506
39* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.70778809
40STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.70238493
41CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.69167699
42* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.68440778
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.65315101
44* E2F1_21310950_ChIP-Seq_MCF-7_Human1.62889119
45* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.58603900
46ELK3_25401928_ChIP-Seq_HUVEC_Human1.58171429
47BP1_19119308_ChIP-ChIP_Hs578T_Human1.57545202
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.54888777
49PKCTHETA_26484144_Chip-Seq_BREAST_Human1.53595620
50MYC_19079543_ChIP-ChIP_MESCs_Mouse1.53447879
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.51057747
52TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49377050
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48038178
54STAT4_19710469_ChIP-ChIP_TH1__Mouse1.46940928
55* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.45722990
56RUNX_20019798_ChIP-Seq_JUKART_Human1.45296559
57DCP1A_22483619_ChIP-Seq_HELA_Human1.44491307
58SPI1_23547873_ChIP-Seq_NB4_Human1.43836700
59NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.41948642
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.41121283
61KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.39495630
62KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.39495630
63KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.39495630
64E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.38083961
65KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37616110
66* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.37462841
67* MAF_26560356_Chip-Seq_TH2_Human1.37369981
68SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36971061
69XRN2_22483619_ChIP-Seq_HELA_Human1.36731808
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35353987
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33604159
72FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.33396433
73ETS1_20019798_ChIP-Seq_JURKAT_Human1.32480532
74MYC_19030024_ChIP-ChIP_MESCs_Mouse1.30221165
75* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.28842954
76ESR1_15608294_ChIP-ChIP_MCF-7_Human1.27396574
77RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.25829831
78* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.25617984
79* KDM2B_26808549_Chip-Seq_JURKAT_Human1.24728201
80KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23549916
81CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22239327
82GABP_19822575_ChIP-Seq_HepG2_Human1.21979966
83NCOR1_26117541_ChIP-Seq_K562_Human1.21744858
84KDM5A_27292631_Chip-Seq_BREAST_Human1.21239903
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20545795
86ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20496515
87SPI1_23127762_ChIP-Seq_K562_Human1.20292360
88EST1_17652178_ChIP-ChIP_JURKAT_Human1.19728467
89KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.17231666
90NELFA_20434984_ChIP-Seq_ESCs_Mouse1.15840542
91GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14804609
92HIF1A_21447827_ChIP-Seq_MCF-7_Human1.13392187
93ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12179619
94ELF1_17652178_ChIP-ChIP_JURKAT_Human1.11928923
95SALL1_21062744_ChIP-ChIP_HESCs_Human1.11833924
96FOXP3_21729870_ChIP-Seq_TREG_Human1.10469958
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08970569
98IRF8_27001747_Chip-Seq_BMDM_Mouse1.08615070
99AR_21909140_ChIP-Seq_LNCAP_Human1.08125244
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08088859
101NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07691082
102NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07380301
103CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07296686
104IRF8_21731497_ChIP-ChIP_J774_Mouse1.05703781
105BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05037293
106VDR_23849224_ChIP-Seq_CD4+_Human1.04449163
107PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04426498
108NANOG_21062744_ChIP-ChIP_HESCs_Human1.04330949
109KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04175200
110JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.03939227
111GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03468712
112HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03345544
113FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03271732
114RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02340307
115* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01587889
116ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01328107
117TFEB_21752829_ChIP-Seq_HELA_Human1.00769162
118CHD1_26751641_Chip-Seq_LNCaP_Human1.00717537
119HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00659458
120CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.00340333
121GATA3_27048872_Chip-Seq_THYMUS_Human0.99098911
122FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97236298
123E2F1_18555785_ChIP-Seq_MESCs_Mouse0.95736666
124ZNF263_19887448_ChIP-Seq_K562_Human0.94988807
125CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94601189
126GATA1_22025678_ChIP-Seq_K562_Human0.93419056
127KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92689592
128MYC_18358816_ChIP-ChIP_MESCs_Mouse0.92440174
129IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.92154538
130SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92153478
131EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91397577
132MYCN_18555785_ChIP-Seq_MESCs_Mouse0.91188272
133SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.90567936
134TTF2_22483619_ChIP-Seq_HELA_Human0.89473791
135DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88595700
136ATF3_27146783_Chip-Seq_COLON_Human0.88150358
137SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.87526930
138* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.87413907
139KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.87359049
140MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.86964791
141ZFX_18555785_ChIP-Seq_MESCs_Mouse0.86608787
142NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.85713795
143STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84443941
144CREB1_26743006_Chip-Seq_LNCaP_Human0.80752286
145P300_27058665_Chip-Seq_ZR-75-30cells_Human0.75816168

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia3.63133237
2MP0002396_abnormal_hematopoietic_system2.92876339
3MP0010352_gastrointestinal_tract_polyps2.75907699
4MP0003300_gastrointestinal_ulcer2.66603662
5MP0003763_abnormal_thymus_physiology2.54495025
6MP0005076_abnormal_cell_differentiation2.53433840
7MP0004808_abnormal_hematopoietic_stem2.50790902
8MP0003303_peritoneal_inflammation2.46473203
9MP0008057_abnormal_DNA_replication2.41557267
10MP0008932_abnormal_embryonic_tissue2.27344033
11MP0001835_abnormal_antigen_presentation2.26268505
12MP0001346_abnormal_lacrimal_gland2.25450237
13MP0000685_abnormal_immune_system2.14189460
14MP0001800_abnormal_humoral_immune2.11736513
15MP0002398_abnormal_bone_marrow2.08473156
16MP0000537_abnormal_urethra_morphology2.01058534
17MP0003077_abnormal_cell_cycle1.99591496
18MP0003436_decreased_susceptibility_to1.99419760
19MP0004233_abnormal_muscle_weight1.97032157
20MP0009278_abnormal_bone_marrow1.96829032
21MP0009333_abnormal_splenocyte_physiolog1.95998227
22MP0002249_abnormal_larynx_morphology1.89086291
23MP0000703_abnormal_thymus_morphology1.88291537
24MP0010094_abnormal_chromosome_stability1.86345840
25MP0005671_abnormal_response_to1.82560682
26MP0001790_abnormal_immune_system1.81487305
27MP0005387_immune_system_phenotype1.81487305
28MP0003693_abnormal_embryo_hatching1.81399102
29MP0003111_abnormal_nucleus_morphology1.81310393
30MP0003705_abnormal_hypodermis_morpholog1.80194535
31MP0002452_abnormal_antigen_presenting1.73649875
32MP0009672_abnormal_birth_weight1.73407215
33MP0002722_abnormal_immune_system1.71427294
34MP0002405_respiratory_system_inflammati1.70086564
35MP0005397_hematopoietic_system_phenotyp1.70059808
36MP0001545_abnormal_hematopoietic_system1.70059808
37MP0008995_early_reproductive_senescence1.67921885
38MP0002420_abnormal_adaptive_immunity1.65852882
39MP0000689_abnormal_spleen_morphology1.64807051
40MP0002723_abnormal_immune_serum1.63384688
41MP0001819_abnormal_immune_cell1.63117635
42MP0005000_abnormal_immune_tolerance1.62813425
43MP0010307_abnormal_tumor_latency1.61964062
44MP0004185_abnormal_adipocyte_glucose1.61769925
45MP0004957_abnormal_blastocyst_morpholog1.60076604
46MP0002877_abnormal_melanocyte_morpholog1.59932052
47MP0002166_altered_tumor_susceptibility1.59789861
48MP0000716_abnormal_immune_system1.59777233
49MP0003786_premature_aging1.55561753
50MP0000490_abnormal_crypts_of1.55304334
51MP0008007_abnormal_cellular_replicative1.54069810
52MP0003566_abnormal_cell_adhesion1.53941974
53MP0000465_gastrointestinal_hemorrhage1.50990609
54MP0000350_abnormal_cell_proliferation1.50500319
55MP0003567_abnormal_fetal_cardiomyocyte1.49987057
56MP0005187_abnormal_penis_morphology1.48482370
57MP0002429_abnormal_blood_cell1.47770538
58MP0005623_abnormal_meninges_morphology1.46350362
59MP0010155_abnormal_intestine_physiology1.45786205
60MP0003123_paternal_imprinting1.44574485
61MP0003984_embryonic_growth_retardation1.41448776
62MP0002088_abnormal_embryonic_growth/wei1.40718321
63MP0003942_abnormal_urinary_system1.40664282
64MP0001730_embryonic_growth_arrest1.38932266
65MP0004197_abnormal_fetal_growth/weight/1.36841137
66MP0002086_abnormal_extraembryonic_tissu1.36199669
67MP0002697_abnormal_eye_size1.33975055
68MP0005464_abnormal_platelet_physiology1.32530812
69MP0003121_genomic_imprinting1.32230548
70MP0001672_abnormal_embryogenesis/_devel1.31696469
71MP0005380_embryogenesis_phenotype1.31696469
72MP0001661_extended_life_span1.30218463
73MP0004510_myositis1.30048926
74MP0004947_skin_inflammation1.27478860
75MP0003315_abnormal_perineum_morphology1.27293874
76MP0005367_renal/urinary_system_phenotyp1.26183558
77MP0000516_abnormal_urinary_system1.26183558
78MP0005025_abnormal_response_to1.24877693
79MP0006054_spinal_hemorrhage1.19799009
80MP0001697_abnormal_embryo_size1.19597041
81MP0001873_stomach_inflammation1.19521746
82MP0009703_decreased_birth_body1.18762712
83MP0002019_abnormal_tumor_incidence1.18137956
84MP0003937_abnormal_limbs/digits/tail_de1.17706850
85MP0008961_abnormal_basal_metabolism1.17545564
86MP0000678_abnormal_parathyroid_gland1.13915208
87MP0002006_tumorigenesis1.13384722
88MP0000733_abnormal_muscle_development1.12938212
89MP0000569_abnormal_digit_pigmentation1.12201783
90MP0005451_abnormal_body_composition1.11860087
91MP0003866_abnormal_defecation1.10654164
92MP0009785_altered_susceptibility_to1.08438800
93MP0005023_abnormal_wound_healing1.06701391
94* MP0002080_prenatal_lethality1.05623743
95MP0000313_abnormal_cell_death1.04996253
96MP0003828_pulmonary_edema1.04661056
97MP0000566_synostosis1.04369574
98MP0001853_heart_inflammation1.03296392
99MP0002419_abnormal_innate_immunity1.01533374
100MP0003935_abnormal_craniofacial_develop0.98914516
101MP0002092_abnormal_eye_morphology0.98835044
102MP0001845_abnormal_inflammatory_respons0.98090518
103* MP0002084_abnormal_developmental_patter0.97313023
104* MP0002925_abnormal_cardiovascular_devel0.96752647
105MP0000631_abnormal_neuroendocrine_gland0.96419197
106* MP0003861_abnormal_nervous_system0.96025344
107MP0004264_abnormal_extraembryonic_tissu0.95770090
108MP0001915_intracranial_hemorrhage0.95418586
109MP0008058_abnormal_DNA_repair0.95382999
110MP0003115_abnormal_respiratory_system0.94063686
111MP0003091_abnormal_cell_migration0.93888146
112MP0003448_altered_tumor_morphology0.93659510
113MP0001286_abnormal_eye_development0.92225027
114MP0010630_abnormal_cardiac_muscle0.92214070
115MP0002933_joint_inflammation0.91916913
116* MP0002085_abnormal_embryonic_tissue0.90815029
117MP0009697_abnormal_copulation0.89046368
118MP0002114_abnormal_axial_skeleton0.87933006
119MP0002148_abnormal_hypersensitivity_rea0.86110639
120MP0003122_maternal_imprinting0.85667364
121MP0000858_altered_metastatic_potential0.83520228
122MP0003385_abnormal_body_wall0.82558509
123MP0005666_abnormal_adipose_tissue0.82521705
124MP0002210_abnormal_sex_determination0.81288277
125MP0005220_abnormal_exocrine_pancreas0.81018741
126MP0002108_abnormal_muscle_morphology0.77928826
127MP0010234_abnormal_vibrissa_follicle0.77834080
128MP0003890_abnormal_embryonic-extraembry0.77813853
129MP0003943_abnormal_hepatobiliary_system0.77132058
130MP0005621_abnormal_cell_physiology0.76949099
131MP0006292_abnormal_olfactory_placode0.75559892
132MP0002081_perinatal_lethality0.74675675
133MP0001145_abnormal_male_reproductive0.74553328
134* MP0000266_abnormal_heart_morphology0.74061035
135MP0000428_abnormal_craniofacial_morphol0.73992983
136MP0008770_decreased_survivor_rate0.73600130
137MP0001944_abnormal_pancreas_morphology0.73116859
138* MP0000432_abnormal_head_morphology0.73105280
139MP0000477_abnormal_intestine_morphology0.72964119
140MP0000767_abnormal_smooth_muscle0.72606915
141MP0001849_ear_inflammation0.72412734
142MP0005310_abnormal_salivary_gland0.71615816
143MP0002111_abnormal_tail_morphology0.69117586
144MP0005375_adipose_tissue_phenotype0.68017112
145MP0003646_muscle_fatigue0.67330206
146MP0001293_anophthalmia0.67145390
147MP0005384_cellular_phenotype0.66653853
148MP0000003_abnormal_adipose_tissue0.65776882
149MP0001929_abnormal_gametogenesis0.65747204
150MP0006035_abnormal_mitochondrial_morpho0.64985934
151MP0003221_abnormal_cardiomyocyte_apopto0.64895677
152MP0002116_abnormal_craniofacial_bone0.64544271

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.53869480
2Chromsome breakage (HP:0040012)4.27804597
3Abnormality of the fingertips (HP:0001211)4.05719462
4Homocystinuria (HP:0002156)3.84488055
5Abnormality of homocysteine metabolism (HP:0010919)3.84488055
6Recurrent viral infections (HP:0004429)3.26830246
7Hyperacusis (HP:0010780)3.24081591
8Birth length less than 3rd percentile (HP:0003561)3.22238038
9Abnormality of the phalanges of the hallux (HP:0010057)3.01274490
10Dysmetric saccades (HP:0000641)3.01043858
11Long eyelashes (HP:0000527)2.98784062
12Truncus arteriosus (HP:0001660)2.90499623
13Abnormality of the distal phalanx of the thumb (HP:0009617)2.88142104
14Ectopic kidney (HP:0000086)2.83273855
15High anterior hairline (HP:0009890)2.78483836
16IgM deficiency (HP:0002850)2.78130096
17Increased density of long bones (HP:0006392)2.77309065
18Abnormality of chromosome segregation (HP:0002916)2.74569632
19Recurrent fungal infections (HP:0002841)2.73190280
20T lymphocytopenia (HP:0005403)2.71613963
21Cellulitis (HP:0100658)2.69364833
22Short 4th metacarpal (HP:0010044)2.68198940
23Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.68198940
24Abnormal delayed hypersensitivity skin test (HP:0002963)2.67212790
25Thrombocytosis (HP:0001894)2.62759268
26Overlapping toe (HP:0001845)2.62311490
27Panhypogammaglobulinemia (HP:0003139)2.57924771
28Volvulus (HP:0002580)2.57868574
29Anal stenosis (HP:0002025)2.52290244
30Microvesicular hepatic steatosis (HP:0001414)2.51654538
31Abnormality of T cell number (HP:0011839)2.49943286
32Intestinal fistula (HP:0100819)2.48667973
33Progressive muscle weakness (HP:0003323)2.42782947
34Absent radius (HP:0003974)2.40379257
35Abnormality of T cells (HP:0002843)2.37628259
36Bowel incontinence (HP:0002607)2.33686551
37Recurrent bronchitis (HP:0002837)2.32097045
38Abnormality of the columella (HP:0009929)2.31953221
39Cortical dysplasia (HP:0002539)2.30969742
40Sparse lateral eyebrow (HP:0005338)2.28630608
41Duplication of thumb phalanx (HP:0009942)2.27123098
42Abnormal large intestine physiology (HP:0012700)2.26695030
43Heterotopia (HP:0002282)2.26474863
44Verrucae (HP:0200043)2.23530138
45Papilloma (HP:0012740)2.23530138
46Agammaglobulinemia (HP:0004432)2.22685659
47Nephroblastoma (Wilms tumor) (HP:0002667)2.21930750
48Neonatal hypoglycemia (HP:0001998)2.21861335
49Cafe-au-lait spot (HP:0000957)2.21745804
50Prominent nose (HP:0000448)2.21743451
51Abnormality of cochlea (HP:0000375)2.21620921
52Abnormality of chromosome stability (HP:0003220)2.20318794
53Increased nuchal translucency (HP:0010880)2.20205976
54Eczematoid dermatitis (HP:0000976)2.20126123
55Cerebral aneurysm (HP:0004944)2.19513451
56Abnormality of B cell number (HP:0010975)2.19190371
57B lymphocytopenia (HP:0010976)2.19190371
58Sandal gap (HP:0001852)2.19106867
59Gastrointestinal inflammation (HP:0004386)2.18982663
60Bicuspid aortic valve (HP:0001647)2.18018463
61Duplicated collecting system (HP:0000081)2.17966184
62Absent forearm bone (HP:0003953)2.15253001
63Aplasia involving forearm bones (HP:0009822)2.15253001
64Abnormality of the aortic arch (HP:0012303)2.13960814
65* Septate vagina (HP:0001153)2.12595784
66Broad palm (HP:0001169)2.12154107
67Renal duplication (HP:0000075)2.11599569
68Hepatoblastoma (HP:0002884)2.11144859
69Broad distal phalanx of finger (HP:0009836)2.09322096
70Inflammation of the large intestine (HP:0002037)2.09067859
71IgA deficiency (HP:0002720)2.08735458
72Basal cell carcinoma (HP:0002671)2.08555426
73Colitis (HP:0002583)2.08341488
74Cutis marmorata (HP:0000965)2.07200135
75Amaurosis fugax (HP:0100576)2.05861641
76Deviation of the thumb (HP:0009603)2.05281172
77Reticulocytopenia (HP:0001896)2.05025605
78Abnormality of T cell physiology (HP:0011840)2.04080189
79Chest pain (HP:0100749)2.03204544
80Myositis (HP:0100614)2.01636232
81Low anterior hairline (HP:0000294)2.01623583
82Abnormality of the calcaneus (HP:0008364)2.01583783
83Deep palmar crease (HP:0006191)2.00687714
84Embryonal renal neoplasm (HP:0011794)1.98874462
85Calcaneovalgus deformity (HP:0001848)1.98007941
86Atresia of the external auditory canal (HP:0000413)1.97639393
87Meningitis (HP:0001287)1.97165021
88Broad thumb (HP:0011304)1.97162817
89Acute myeloid leukemia (HP:0004808)1.97067015
90Transposition of the great arteries (HP:0001669)1.97018076
91Abnormal connection of the cardiac segments (HP:0011545)1.97018076
92Abnormal ventriculo-arterial connection (HP:0011563)1.97018076
93Short middle phalanx of the 5th finger (HP:0004220)1.93797965
94Abnormality of the parathyroid morphology (HP:0011766)1.93735839
95Lymphopenia (HP:0001888)1.92132970
96Spontaneous hematomas (HP:0007420)1.91356517
97Abnormality of cells of the lymphoid lineage (HP:0012140)1.91280028
98Ankyloglossia (HP:0010296)1.90734526
99Elevated erythrocyte sedimentation rate (HP:0003565)1.89853877
100Macroorchidism (HP:0000053)1.89848100
101Patellar aplasia (HP:0006443)1.89606375
102Short 5th finger (HP:0009237)1.89469353
103Meckel diverticulum (HP:0002245)1.89297894
104Abnormality of the preputium (HP:0100587)1.89252355
105Choanal atresia (HP:0000453)1.89200408
106Patellar dislocation (HP:0002999)1.89046160
107Aplasia/Hypoplasia of the uvula (HP:0010293)1.88824941
108Attention deficit hyperactivity disorder (HP:0007018)1.87896540
109Diastasis recti (HP:0001540)1.87784246
110Abnormal platelet volume (HP:0011876)1.87514236
111Proximal placement of thumb (HP:0009623)1.87344721
112Dislocated radial head (HP:0003083)1.86780227
113Abnormality of the ileum (HP:0001549)1.86344192
114Interstitial pulmonary disease (HP:0006530)1.85898078
115Progressive external ophthalmoplegia (HP:0000590)1.85869499
116Ependymoma (HP:0002888)1.85488375
117Abnormality of the 4th metacarpal (HP:0010012)1.85384366
118Hematochezia (HP:0002573)1.84063664
119Mediastinal lymphadenopathy (HP:0100721)1.82750741
120Abnormally folded helix (HP:0008544)1.82608467
121Rectal prolapse (HP:0002035)1.82438043
122Arterial thrombosis (HP:0004420)1.81661525
123Embryonal neoplasm (HP:0002898)1.80101451
124Abnormality of the intervertebral disk (HP:0005108)1.79907919
125Abnormality of the radial head (HP:0003995)1.79507382
126Lymphoma (HP:0002665)1.78550552
127Acute lymphatic leukemia (HP:0006721)1.77659609
128Impaired proprioception (HP:0010831)1.77335038
129Neoplasm of the adrenal cortex (HP:0100641)1.76762315
130Short thumb (HP:0009778)1.76724120
131Thyroiditis (HP:0100646)1.76569831
132Prolonged bleeding time (HP:0003010)1.76443531
133Chronic mucocutaneous candidiasis (HP:0002728)1.76106784
134Recurrent cutaneous fungal infections (HP:0011370)1.76106784
135Rectovaginal fistula (HP:0000143)1.75540456
136Rectal fistula (HP:0100590)1.75540456
137Periodontitis (HP:0000704)1.75529496
138Vertebral arch anomaly (HP:0008438)1.74394827
139Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.73337036
140Petechiae (HP:0000967)1.72676202
141Selective tooth agenesis (HP:0001592)1.72402076
142Narrow palate (HP:0000189)1.71944961
143Hyperthyroidism (HP:0000836)1.71820042
144Recurrent abscess formation (HP:0002722)1.71784464
145Skull defect (HP:0001362)1.71781133
146Disproportionate tall stature (HP:0001519)1.71382570
147Ureteral duplication (HP:0000073)1.70195035
148Increased IgE level (HP:0003212)1.70115901
149Renovascular hypertension (HP:0100817)1.69889917
150Colon cancer (HP:0003003)1.69794711
151Multiple enchondromatosis (HP:0005701)1.69477046
152Myelodysplasia (HP:0002863)1.69373372
153Spinal cord lesions (HP:0100561)1.69362245
154Syringomyelia (HP:0003396)1.69362245
155Chronic otitis media (HP:0000389)1.69094530
156Combined immunodeficiency (HP:0005387)1.69016223
157Nasal polyposis (HP:0100582)1.68961361
158* Skin tags (HP:0010609)1.68817811
159Self-mutilation (HP:0000742)1.68106278
160Medulloblastoma (HP:0002885)1.67056342
161Vaginal fistula (HP:0004320)1.66235668
162Elfin facies (HP:0004428)1.65533735
163High pitched voice (HP:0001620)1.65529282
164Coarctation of aorta (HP:0001680)1.64666493
165Eosinophilia (HP:0001880)1.64037953
166Truncal obesity (HP:0001956)1.63658354
167Fatigue (HP:0012378)1.63473366
168Viral hepatitis (HP:0006562)1.61675941
169Severe combined immunodeficiency (HP:0004430)1.61203174
170Cutaneous melanoma (HP:0012056)1.60792718
171Deep philtrum (HP:0002002)1.60648143
172Obsessive-compulsive behavior (HP:0000722)1.60563124
173Trigonocephaly (HP:0000243)1.60206220
174Severe short stature (HP:0003510)1.59937068
175Recurrent bacterial skin infections (HP:0005406)1.59348301
176Urethral obstruction (HP:0000796)1.59294336
17711 pairs of ribs (HP:0000878)1.59009010
178Leukocytosis (HP:0001974)1.58592028
179Pustule (HP:0200039)1.58153653
180Broad face (HP:0000283)1.58149154

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.78740747
2MAP4K13.77281385
3MAP3K103.75503241
4CAMK1G3.49856859
5CDK123.28791663
6PKN22.69345617
7ICK2.67385607
8SMG12.60902231
9TRIB32.54883314
10STK102.32246501
11TTK2.18037426
12CDC72.08436560
13SRPK12.07412580
14BUB11.98994661
15PNCK1.91719650
16PASK1.78490502
17TXK1.74313237
18ZAP701.71177162
19JAK31.70073213
20RPS6KA41.64281902
21BTK1.62772263
22CHEK21.55597288
23LRRK21.52216888
24RPS6KB21.50933014
25PRPF4B1.44470350
26ERN11.41134657
27ITK1.40408209
28BRD41.40064483
29IRAK31.36386141
30MAP2K31.35753801
31PTK61.31927525
32GRK61.30571764
33ALK1.29878356
34PIM11.29683890
35NEK21.25111620
36CSF1R1.17290131
37TYK21.17256540
38EPHA31.15572063
39FGFR31.14932754
40EIF2AK11.14798215
41IRAK21.14484622
42KSR21.14424269
43CHUK1.13251150
44AKT31.13243225
45SCYL21.12979695
46CDK41.12885188
47TTN1.10752200
48RIPK11.10248882
49TGFBR11.10203679
50TBK11.08278113
51RAF11.06529307
52BRSK21.04754664
53FLT31.02800776
54FGFR41.00463860
55HIPK20.98988058
56MAP3K80.96782337
57HCK0.95908485
58MTOR0.95393091
59CDK10.94981667
60SYK0.94446416
61TGFBR20.93489145
62TAOK10.90881560
63CDK60.90710353
64TAOK30.90151337
65PLK40.89538163
66TSSK60.88869887
67SIK10.88611592
68SIK30.88539471
69TEC0.87719708
70MAP3K140.87548562
71STK40.87093325
72SIK20.85499999
73MARK30.84409842
74IKBKE0.84364896
75IKBKB0.80932117
76CDK30.80834684
77PIM20.77953053
78BRSK10.77769888
79PLK10.77470516
80CDK90.76249626
81CHEK10.75810174
82DMPK0.75712703
83CLK10.75669713
84JAK10.75342105
85MAP3K30.75126004
86LCK0.75026699
87EPHB10.73575152
88ATR0.73113332
89CSK0.73080598
90IRAK40.73030370
91KSR10.71979107
92CAMK1D0.69053146
93YES10.69007090
94ACVR1B0.68038449
95CDK70.66767983
96LATS10.65878895
97PDGFRA0.65595189
98GSK3B0.64716446
99PLK30.64562547
100MAP3K70.62938388
101PRKAA10.62075189
102MKNK10.61311882
103BLK0.61098311
104JAK20.60727072
105MAPK140.60469376
106KIT0.59662605
107PAK40.59542145
108TAF10.59274746
109RPS6KB10.59232754
110MKNK20.59033281
111NLK0.58974576
112PAK20.58467169
113RPS6KA60.57759184
114WNK10.57663632
115PDGFRB0.57651623
116TYRO30.56765183
117MAPK110.55202376
118AKT10.54932629
119WEE10.53723879
120RPS6KC10.53547057
121RPS6KL10.53547057
122CSNK1E0.53504443
123FGFR20.53406037
124AURKB0.53291710
125PRKDC0.53245758
126MAPKAPK20.52573701
127CDK20.52239978
128DYRK30.51067123
129STK30.50291394
130MAP3K20.50204154
131ATM0.49959115
132RPS6KA10.49655857
133MELK0.49556993
134* MAPK100.49345452
135AURKA0.48886236
136CAMK40.48865129
137CDK80.47365589
138RPS6KA20.45914902
139AKT20.45868127
140LYN0.43320571
141SGK30.43032362
142RET0.42013939
143MAP3K110.41902870
144MAPK10.36724568
145MAPK80.33224861
146SGK20.32171683
147MAPK90.31220202
148MARK20.30141568
149PRKAA20.29567017
150FGFR10.28454657
151SGK10.27300980

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.30222918
2NF-kappa B signaling pathway_Homo sapiens_hsa040641.97037092
3DNA replication_Homo sapiens_hsa030301.96317212
4B cell receptor signaling pathway_Homo sapiens_hsa046621.94839280
5Chronic myeloid leukemia_Homo sapiens_hsa052201.94405407
6Fanconi anemia pathway_Homo sapiens_hsa034601.82133675
7Antigen processing and presentation_Homo sapiens_hsa046121.80401426
8Spliceosome_Homo sapiens_hsa030401.72938834
9Leishmaniasis_Homo sapiens_hsa051401.71743934
10T cell receptor signaling pathway_Homo sapiens_hsa046601.70838804
11Measles_Homo sapiens_hsa051621.61446549
12Acute myeloid leukemia_Homo sapiens_hsa052211.59445927
13Osteoclast differentiation_Homo sapiens_hsa043801.54283598
14Herpes simplex infection_Homo sapiens_hsa051681.54142547
15Cell cycle_Homo sapiens_hsa041101.53249675
16Viral myocarditis_Homo sapiens_hsa054161.49565621
17RNA transport_Homo sapiens_hsa030131.47626510
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.46936919
19Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.45217223
20Selenocompound metabolism_Homo sapiens_hsa004501.43287832
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.43138569
22Mismatch repair_Homo sapiens_hsa034301.42393870
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.41630598
24Base excision repair_Homo sapiens_hsa034101.41620851
25Small cell lung cancer_Homo sapiens_hsa052221.39383657
26MicroRNAs in cancer_Homo sapiens_hsa052061.38817231
27RNA polymerase_Homo sapiens_hsa030201.38782871
28Transcriptional misregulation in cancer_Homo sapiens_hsa052021.38499760
29Toxoplasmosis_Homo sapiens_hsa051451.37690198
30mRNA surveillance pathway_Homo sapiens_hsa030151.36445367
31Hepatitis B_Homo sapiens_hsa051611.35433668
32Allograft rejection_Homo sapiens_hsa053301.35363655
33Viral carcinogenesis_Homo sapiens_hsa052031.33945759
34HTLV-I infection_Homo sapiens_hsa051661.33019325
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.30619430
36Longevity regulating pathway - mammal_Homo sapiens_hsa042111.30350665
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.29174226
38Hematopoietic cell lineage_Homo sapiens_hsa046401.24796477
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.22600796
40Apoptosis_Homo sapiens_hsa042101.21404503
41Notch signaling pathway_Homo sapiens_hsa043301.19960698
42Pancreatic cancer_Homo sapiens_hsa052121.19577717
43Epstein-Barr virus infection_Homo sapiens_hsa051691.19336412
44One carbon pool by folate_Homo sapiens_hsa006701.18613439
45Colorectal cancer_Homo sapiens_hsa052101.15453113
46Basal transcription factors_Homo sapiens_hsa030221.14968132
47Non-small cell lung cancer_Homo sapiens_hsa052231.14794443
48mTOR signaling pathway_Homo sapiens_hsa041501.12325998
49Lysine degradation_Homo sapiens_hsa003101.11890827
50Neurotrophin signaling pathway_Homo sapiens_hsa047221.10836970
51Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.10597563
52Leukocyte transendothelial migration_Homo sapiens_hsa046701.10445479
53Type II diabetes mellitus_Homo sapiens_hsa049301.09816501
54Biosynthesis of amino acids_Homo sapiens_hsa012301.08397415
55Legionellosis_Homo sapiens_hsa051341.07220731
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.07076785
57Oocyte meiosis_Homo sapiens_hsa041141.06687015
58Influenza A_Homo sapiens_hsa051641.05609479
59ErbB signaling pathway_Homo sapiens_hsa040121.04842589
60Toll-like receptor signaling pathway_Homo sapiens_hsa046201.04387031
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01708456
62NOD-like receptor signaling pathway_Homo sapiens_hsa046211.01580347
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01072265
64p53 signaling pathway_Homo sapiens_hsa041151.01021198
65TNF signaling pathway_Homo sapiens_hsa046681.00590091
66Insulin signaling pathway_Homo sapiens_hsa049101.00179542
67Pyrimidine metabolism_Homo sapiens_hsa002400.98984254
68Endometrial cancer_Homo sapiens_hsa052130.95182717
69RNA degradation_Homo sapiens_hsa030180.94866026
70Prolactin signaling pathway_Homo sapiens_hsa049170.94045990
71Non-homologous end-joining_Homo sapiens_hsa034500.93776800
72Ribosome_Homo sapiens_hsa030100.92310318
73Shigellosis_Homo sapiens_hsa051310.92185944
74Proteoglycans in cancer_Homo sapiens_hsa052050.92045221
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91992713
76Thyroid cancer_Homo sapiens_hsa052160.91705817
77Platelet activation_Homo sapiens_hsa046110.91328864
78Asthma_Homo sapiens_hsa053100.89361802
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89358730
80Chemokine signaling pathway_Homo sapiens_hsa040620.89138537
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87384985
82Prostate cancer_Homo sapiens_hsa052150.86489171
83Adherens junction_Homo sapiens_hsa045200.86123145
84AMPK signaling pathway_Homo sapiens_hsa041520.85801599
85Systemic lupus erythematosus_Homo sapiens_hsa053220.83003124
86Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.82524467
87Insulin resistance_Homo sapiens_hsa049310.80594504
88VEGF signaling pathway_Homo sapiens_hsa043700.80232589
89HIF-1 signaling pathway_Homo sapiens_hsa040660.79651498
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.79024957
91TGF-beta signaling pathway_Homo sapiens_hsa043500.78827263
92Nucleotide excision repair_Homo sapiens_hsa034200.78375662
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77879873
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.76423379
95Graft-versus-host disease_Homo sapiens_hsa053320.76361488
96Renal cell carcinoma_Homo sapiens_hsa052110.75240231
97Tuberculosis_Homo sapiens_hsa051520.75048846
98Homologous recombination_Homo sapiens_hsa034400.74520163
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73179529
100Type I diabetes mellitus_Homo sapiens_hsa049400.72926267
101Wnt signaling pathway_Homo sapiens_hsa043100.70359714
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70115230
103Pathways in cancer_Homo sapiens_hsa052000.70013901
104FoxO signaling pathway_Homo sapiens_hsa040680.69496796
105Focal adhesion_Homo sapiens_hsa045100.69160039
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67508636
107Inositol phosphate metabolism_Homo sapiens_hsa005620.66172965
108Malaria_Homo sapiens_hsa051440.64850549
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64141155
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63277289
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63088982
112Melanoma_Homo sapiens_hsa052180.61597699
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61376587
114Fatty acid biosynthesis_Homo sapiens_hsa000610.60777341
115Hepatitis C_Homo sapiens_hsa051600.58977423
116Choline metabolism in cancer_Homo sapiens_hsa052310.58870753
117Glioma_Homo sapiens_hsa052140.58700798
118Basal cell carcinoma_Homo sapiens_hsa052170.57574596
119Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57441468
120Pertussis_Homo sapiens_hsa051330.56873486
121Vitamin B6 metabolism_Homo sapiens_hsa007500.56467038
122Glucagon signaling pathway_Homo sapiens_hsa049220.55963337
123Purine metabolism_Homo sapiens_hsa002300.55703061
124Bladder cancer_Homo sapiens_hsa052190.55518578
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55401606
1262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55295531
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.53737834
128Circadian rhythm_Homo sapiens_hsa047100.53550280
129Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53269523
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51211293
131Autoimmune thyroid disease_Homo sapiens_hsa053200.50932780
132Hedgehog signaling pathway_Homo sapiens_hsa043400.50360632
133Pentose phosphate pathway_Homo sapiens_hsa000300.45772528
134Maturity onset diabetes of the young_Homo sapiens_hsa049500.42825190
135Carbon metabolism_Homo sapiens_hsa012000.42593303
136Estrogen signaling pathway_Homo sapiens_hsa049150.39599197
137Hippo signaling pathway_Homo sapiens_hsa043900.36702303
138Dorso-ventral axis formation_Homo sapiens_hsa043200.32842431
139Prion diseases_Homo sapiens_hsa050200.29787170
140Long-term potentiation_Homo sapiens_hsa047200.26030632

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