ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.57584670
2	DNA deamination (GO:0045006)	4.39468267
3	indolalkylamine metabolic process (GO:0006586)	4.13746617
4	water-soluble vitamin biosynthetic process (GO:0042364)	3.79025430
5	indole-containing compound catabolic process (GO:0042436)	3.75978740
6	indolalkylamine catabolic process (GO:0046218)	3.75978740
7	tryptophan catabolic process (GO:0006569)	3.75978740
8	response to pheromone (GO:0019236)	3.72135553
9	activated T cell proliferation (GO:0050798)	3.63109921
10	positive regulation of granulocyte differentiation (GO:0030854)	3.59376464
11	L-fucose metabolic process (GO:0042354)	3.55234306
12	L-fucose catabolic process (GO:0042355)	3.55234306
13	fucose catabolic process (GO:0019317)	3.55234306
14	cellular response to interleukin-15 (GO:0071350)	3.47539230
15	mast cell activation (GO:0045576)	3.40458383
16	sulfation (GO:0051923)	3.39921212
17	mast cell degranulation (GO:0043303)	3.30328758
18	mast cell activation involved in immune response (GO:0002279)	3.30328758
19	negative regulation of telomere maintenance (GO:0032205)	3.29952886
20	neurofilament cytoskeleton organization (GO:0060052)	3.28770251
21	indole-containing compound metabolic process (GO:0042430)	3.11418328
22	tryptophan metabolic process (GO:0006568)	3.06954167
23	platelet dense granule organization (GO:0060155)	3.06361717
24	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.01524451
25	negative T cell selection (GO:0043383)	3.00202907
26	kynurenine metabolic process (GO:0070189)	3.00139599
27	cell proliferation in forebrain (GO:0021846)	2.99236147
28	positive regulation of defense response to virus by host (GO:0002230)	2.93414451
29	protein polyglutamylation (GO:0018095)	2.88010826
30	male meiosis (GO:0007140)	2.85396086
31	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.84960912
32	regulation of translation, ncRNA-mediated (GO:0045974)	2.84960912
33	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.84960912
34	cellular biogenic amine catabolic process (GO:0042402)	2.84185818
35	amine catabolic process (GO:0009310)	2.84185818
36	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.82214779
37	cytidine metabolic process (GO:0046087)	2.82111501
38	cytidine catabolic process (GO:0006216)	2.82111501
39	cytidine deamination (GO:0009972)	2.82111501
40	epithelial cilium movement (GO:0003351)	2.78330151
41	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.76132795
42	gamma-aminobutyric acid transport (GO:0015812)	2.74196481
43	response to interleukin-15 (GO:0070672)	2.73455427
44	lysosome localization (GO:0032418)	2.72001236
45	dentate gyrus development (GO:0021542)	2.71716983
46	rhodopsin mediated signaling pathway (GO:0016056)	2.70969938
47	protein K11-linked deubiquitination (GO:0035871)	2.70437422
48	serotonin metabolic process (GO:0042428)	2.69695731
49	cellular response to ATP (GO:0071318)	2.66721348
50	transmission of nerve impulse (GO:0019226)	2.66257203
51	head development (GO:0060322)	2.65556883
52	regulation of natural killer cell mediated immunity (GO:0002715)	2.65091890
53	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	2.65091890
54	glyoxylate metabolic process (GO:0046487)	2.63138193
55	interferon-gamma production (GO:0032609)	2.62832637
56	detection of light stimulus involved in sensory perception (GO:0050962)	2.61750452
57	detection of light stimulus involved in visual perception (GO:0050908)	2.61750452
58	positive T cell selection (GO:0043368)	2.61544502
59	regulation of DNA methylation (GO:0044030)	2.60471032
60	tolerance induction (GO:0002507)	2.60404388
61	protein-cofactor linkage (GO:0018065)	2.59913924
62	primary amino compound metabolic process (GO:1901160)	2.59352596
63	regulation of chronic inflammatory response (GO:0002676)	2.57730475
64	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.56338801
65	natural killer cell activation (GO:0030101)	2.55553197
66	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.52713233
67	positive regulation of fatty acid oxidation (GO:0046321)	2.51745596
68	axoneme assembly (GO:0035082)	2.51076619
69	positive regulation of calcium-mediated signaling (GO:0050850)	2.49744020
70	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.49739030
71	reflex (GO:0060004)	2.49279606
72	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.48858399
73	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.48541323
74	NADH dehydrogenase complex assembly (GO:0010257)	2.48541323
75	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.48541323
76	hypothalamus development (GO:0021854)	2.46085633
77	protein complex biogenesis (GO:0070271)	2.45110261
78	kidney morphogenesis (GO:0060993)	2.44897551
79	negative regulation of systemic arterial blood pressure (GO:0003085)	2.44026694
80	adaptation of signaling pathway (GO:0023058)	2.43927910
81	positive regulation of fatty acid transport (GO:2000193)	2.43161960
82	regulation of isotype switching to IgG isotypes (GO:0048302)	2.41379365
83	negative thymic T cell selection (GO:0045060)	2.40454141
84	thyroid hormone metabolic process (GO:0042403)	2.39716579
85	regulation of telomere maintenance (GO:0032204)	2.38711158
86	regulation of cell killing (GO:0031341)	2.38494669
87	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.37929284
88	positive regulation of gamma-delta T cell activation (GO:0046645)	2.36849425
89	cAMP catabolic process (GO:0006198)	2.36246874
90	respiratory chain complex IV assembly (GO:0008535)	2.35966615
91	neural tube formation (GO:0001841)	2.35877462
92	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.35033357
93	regulation of granulocyte differentiation (GO:0030852)	2.34776612
94	neuronal action potential (GO:0019228)	2.34624765
95	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.34331233
96	piRNA metabolic process (GO:0034587)	2.33845769
97	dopamine transport (GO:0015872)	2.33537152
98	NAD biosynthetic process (GO:0009435)	2.31873135
99	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.31511488
100	parturition (GO:0007567)	2.31265108

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.22117523
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.04362769
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.15275090
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.06238071
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.97380666
6	VDR_22108803_ChIP-Seq_LS180_Human	2.95578811
7	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.74280810
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.60427243
9	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.18799903
10	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.13511813
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.07245192
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.02376716
13	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.99151005
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.97421435
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.96447885
16	IRF1_19129219_ChIP-ChIP_H3396_Human	1.93396224
17	ER_23166858_ChIP-Seq_MCF-7_Human	1.84411764
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.77816519
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.71079630
20	RUNX_20019798_ChIP-Seq_JUKART_Human	1.69500438
21	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.64831512
22	P300_19829295_ChIP-Seq_ESCs_Human	1.62164712
23	BCAT_22108803_ChIP-Seq_LS180_Human	1.60937815
24	EWS_26573619_Chip-Seq_HEK293_Human	1.60512234
25	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.59479924
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.51757102
27	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.48688233
28	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.45717585
29	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.43649539
30	FUS_26573619_Chip-Seq_HEK293_Human	1.42925296
31	CBP_20019798_ChIP-Seq_JUKART_Human	1.42541948
32	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.42541948
33	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.41666613
34	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.40014019
35	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.38938615
36	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.37310308
37	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.37310308
38	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.35424743
39	TP53_22573176_ChIP-Seq_HFKS_Human	1.33335375
40	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.30993109
41	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.29832812
42	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.29766123
43	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.28129658
44	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.26647183
45	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.25810444
46	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.25699785
47	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.25357148
48	REST_21632747_ChIP-Seq_MESCs_Mouse	1.25060005
49	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.24958537
50	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.24735185
51	STAT3_23295773_ChIP-Seq_U87_Human	1.24058629
52	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.23831068
53	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.22343204
54	GATA3_26560356_Chip-Seq_TH2_Human	1.20370384
55	AR_25329375_ChIP-Seq_VCAP_Human	1.20230758
56	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.18660079
57	TCF4_23295773_ChIP-Seq_U87_Human	1.18281381
58	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.17775674
59	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.17775674
60	NCOR_22424771_ChIP-Seq_293T_Human	1.17333942
61	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.16203382
62	TCF4_22108803_ChIP-Seq_LS180_Human	1.15069883
63	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.14764575
64	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.14655608
65	SMAD4_21799915_ChIP-Seq_A2780_Human	1.14300692
66	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.14056413
67	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.12520977
68	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.11778037
69	GATA3_27048872_Chip-Seq_THYMUS_Human	1.11621861
70	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.10001045
71	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.08103342
72	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.07944763
73	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.07489115
74	AR_21572438_ChIP-Seq_LNCaP_Human	1.06846347
75	RUNX2_22187159_ChIP-Seq_PCA_Human	1.06614507
76	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.05973935
77	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.05628988
78	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.04654010
79	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.04418289
80	NANOG_19829295_ChIP-Seq_ESCs_Human	1.03945027
81	SOX2_19829295_ChIP-Seq_ESCs_Human	1.03945027
82	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.01131253
83	NANOG_20526341_ChIP-Seq_ESCs_Human	1.00670526
84	TAF15_26573619_Chip-Seq_HEK293_Human	1.00261323
85	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.00235836
86	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.99833729
87	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.99638403
88	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.99461920
89	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.98248199
90	MYB_26560356_Chip-Seq_TH2_Human	0.97764289
91	RNF2_27304074_Chip-Seq_NSC_Mouse	0.97757554
92	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.97129229
93	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.97055479
94	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.96891176
95	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.96630164
96	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.95797108
97	MYC_18940864_ChIP-ChIP_HL60_Human	0.94947492
98	HTT_18923047_ChIP-ChIP_STHdh_Human	0.94714266
99	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.94161008
100	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.93211859

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	3.63541775
2	MP0005671_abnormal_response_to	3.11931458
3	MP0002876_abnormal_thyroid_physiology	2.43098321
4	MP0003763_abnormal_thymus_physiology	2.39848860
5	MP0008995_early_reproductive_senescence	2.37366897
6	MP0005646_abnormal_pituitary_gland	2.35941747
7	MP0003646_muscle_fatigue	2.33496195
8	MP0008877_abnormal_DNA_methylation	2.10343140
9	MP0003195_calcinosis	2.04921920
10	MP0001986_abnormal_taste_sensitivity	1.96807036
11	MP0002837_dystrophic_cardiac_calcinosis	1.95209919
12	MP0003724_increased_susceptibility_to	1.90134116
13	MP0006292_abnormal_olfactory_placode	1.87173438
14	MP0008872_abnormal_physiological_respon	1.86166583
15	MP0001485_abnormal_pinna_reflex	1.81405930
16	MP0002102_abnormal_ear_morphology	1.81290830
17	MP0004885_abnormal_endolymph	1.75974714
18	MP0009745_abnormal_behavioral_response	1.74672229
19	MP0009046_muscle_twitch	1.73039296
20	MP0002653_abnormal_ependyma_morphology	1.71663502
21	MP0002163_abnormal_gland_morphology	1.71636259
22	MP0004142_abnormal_muscle_tone	1.69075857
23	MP0005551_abnormal_eye_electrophysiolog	1.65811896
24	MP0001968_abnormal_touch/_nociception	1.64678034
25	MP0001800_abnormal_humoral_immune	1.63122954
26	MP0009785_altered_susceptibility_to	1.62967392
27	MP0003880_abnormal_central_pattern	1.59139537
28	MP0001501_abnormal_sleep_pattern	1.55052617
29	MP0000685_abnormal_immune_system	1.54963246
30	MP0005379_endocrine/exocrine_gland_phen	1.54571188
31	MP0001790_abnormal_immune_system	1.52278355
32	MP0005387_immune_system_phenotype	1.52278355
33	MP0005645_abnormal_hypothalamus_physiol	1.46172270
34	MP0006072_abnormal_retinal_apoptosis	1.43409384
35	MP0001835_abnormal_antigen_presentation	1.41694504
36	MP0002138_abnormal_hepatobiliary_system	1.40972059
37	MP0005075_abnormal_melanosome_morpholog	1.37964577
38	MP0000631_abnormal_neuroendocrine_gland	1.37211381
39	MP0005000_abnormal_immune_tolerance	1.35286101
40	MP0001919_abnormal_reproductive_system	1.35251017
41	MP0002272_abnormal_nervous_system	1.34631584
42	MP0004742_abnormal_vestibular_system	1.32719435
43	MP0004381_abnormal_hair_follicle	1.32699631
44	MP0009333_abnormal_splenocyte_physiolog	1.31727926
45	MP0005389_reproductive_system_phenotype	1.31636490
46	MP0002723_abnormal_immune_serum	1.30179866
47	MP0006082_CNS_inflammation	1.29115093
48	MP0002420_abnormal_adaptive_immunity	1.26547043
49	MP0001819_abnormal_immune_cell	1.24800221
50	MP0002148_abnormal_hypersensitivity_rea	1.23831238
51	MP0002064_seizures	1.22761874
52	MP0006276_abnormal_autonomic_nervous	1.20109267
53	MP0002160_abnormal_reproductive_system	1.19784542
54	MP0005025_abnormal_response_to	1.16524852
55	MP0001873_stomach_inflammation	1.12782688
56	MP0005253_abnormal_eye_physiology	1.12735423
57	MP0001970_abnormal_pain_threshold	1.11816090
58	MP0003121_genomic_imprinting	1.11118909
59	MP0005410_abnormal_fertilization	1.10517959
60	MP0000569_abnormal_digit_pigmentation	1.09987590
61	MP0003011_delayed_dark_adaptation	1.08983849
62	MP0003123_paternal_imprinting	1.08667182
63	MP0008875_abnormal_xenobiotic_pharmacok	1.08472005
64	MP0002452_abnormal_antigen_presenting	1.08249213
65	MP0002733_abnormal_thermal_nociception	1.07369161
66	MP0002736_abnormal_nociception_after	1.07263136
67	MP0001529_abnormal_vocalization	1.03771832
68	MP0005310_abnormal_salivary_gland	1.02802991
69	MP0003136_yellow_coat_color	1.02183954
70	MP0005377_hearing/vestibular/ear_phenot	1.01959968
71	MP0003878_abnormal_ear_physiology	1.01959968
72	MP0000716_abnormal_immune_system	1.01091800
73	MP0002277_abnormal_respiratory_mucosa	1.00967967
74	MP0009764_decreased_sensitivity_to	0.98908447
75	MP0001486_abnormal_startle_reflex	0.97561259
76	MP0000703_abnormal_thymus_morphology	0.97091915
77	MP0002693_abnormal_pancreas_physiology	0.94356208
78	MP0002405_respiratory_system_inflammati	0.93770002
79	MP0001905_abnormal_dopamine_level	0.93476260
80	MP0005167_abnormal_blood-brain_barrier	0.92411615
81	MP0002572_abnormal_emotion/affect_behav	0.91285590
82	MP0002638_abnormal_pupillary_reflex	0.91266134
83	MP0004145_abnormal_muscle_electrophysio	0.89212815
84	MP0000372_irregular_coat_pigmentation	0.87937352
85	MP0002735_abnormal_chemical_nociception	0.87915262
86	MP0002557_abnormal_social/conspecific_i	0.87851751
87	MP0002254_reproductive_system_inflammat	0.87193800
88	MP0000689_abnormal_spleen_morphology	0.86912789
89	MP0001764_abnormal_homeostasis	0.86676021
90	MP0002398_abnormal_bone_marrow	0.86675901
91	MP0005174_abnormal_tail_pigmentation	0.86359004
92	MP0000049_abnormal_middle_ear	0.86309897
93	MP0001984_abnormal_olfaction	0.85899571
94	MP0003635_abnormal_synaptic_transmissio	0.85597634
95	MP0002067_abnormal_sensory_capabilities	0.83252461
96	MP0008789_abnormal_olfactory_epithelium	0.82571327
97	MP0001845_abnormal_inflammatory_respons	0.81612887
98	MP0005084_abnormal_gallbladder_morpholo	0.78709084
99	MP0000026_abnormal_inner_ear	0.78447687
100	MP0003786_premature_aging	0.78249845

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the renal collecting system (HP:0004742)	3.85971926
2	Pancreatic cysts (HP:0001737)	3.79789160
3	Pancreatic fibrosis (HP:0100732)	3.60265396
4	Congenital stationary night blindness (HP:0007642)	3.56452324
5	Duplicated collecting system (HP:0000081)	3.47981469
6	True hermaphroditism (HP:0010459)	3.30100984
7	Molar tooth sign on MRI (HP:0002419)	3.25454507
8	Abnormality of midbrain morphology (HP:0002418)	3.25454507
9	Abnormality of T cell number (HP:0011839)	3.22434855
10	Abnormality of B cell number (HP:0010975)	3.21406430
11	Thyroiditis (HP:0100646)	3.09548303
12	Severe combined immunodeficiency (HP:0004430)	3.06368111
13	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.98938697
14	Abnormality of DNA repair (HP:0003254)	2.97545259
15	T lymphocytopenia (HP:0005403)	2.92335381
16	Abnormal rod and cone electroretinograms (HP:0008323)	2.91764837
17	Type II lissencephaly (HP:0007260)	2.81553384
18	Nephronophthisis (HP:0000090)	2.78823736
19	Abnormality of the renal cortex (HP:0011035)	2.76514937
20	Progressive cerebellar ataxia (HP:0002073)	2.74265843
21	Eosinophilia (HP:0001880)	2.73333578
22	IgG deficiency (HP:0004315)	2.72847479
23	Abnormality of eosinophils (HP:0001879)	2.71133999
24	Stomatitis (HP:0010280)	2.68156662
25	Chronic hepatic failure (HP:0100626)	2.62444448
26	Autoimmune hemolytic anemia (HP:0001890)	2.59631128
27	Absent thumb (HP:0009777)	2.55301846
28	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.54351443
29	Autoimmune thrombocytopenia (HP:0001973)	2.52741447
30	Pendular nystagmus (HP:0012043)	2.51309322
31	Asplenia (HP:0001746)	2.49758684
32	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.49604003
33	Absent/shortened dynein arms (HP:0200106)	2.49604003
34	Abolished electroretinogram (ERG) (HP:0000550)	2.49097884
35	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.48290638
36	Abnormality of the renal medulla (HP:0100957)	2.44729141
37	Gaze-evoked nystagmus (HP:0000640)	2.43674038
38	Attenuation of retinal blood vessels (HP:0007843)	2.43304004
39	Abnormality of T cells (HP:0002843)	2.43114162
40	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.42428268
41	Ectopic kidney (HP:0000086)	2.42062220
42	Thyroid-stimulating hormone excess (HP:0002925)	2.35656494
43	Congenital sensorineural hearing impairment (HP:0008527)	2.32989434
44	Lipid accumulation in hepatocytes (HP:0006561)	2.31177466
45	Stomach cancer (HP:0012126)	2.29559721
46	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.27103710
47	Chromsome breakage (HP:0040012)	2.26961488
48	Genetic anticipation (HP:0003743)	2.26161977
49	Agitation (HP:0000713)	2.22021410
50	Combined immunodeficiency (HP:0005387)	2.20757621
51	Elevated erythrocyte sedimentation rate (HP:0003565)	2.20644821
52	B lymphocytopenia (HP:0010976)	2.20252976
53	Reticulocytopenia (HP:0001896)	2.17297556
54	Panhypogammaglobulinemia (HP:0003139)	2.17194441
55	Cystic liver disease (HP:0006706)	2.16719010
56	Hyperventilation (HP:0002883)	2.15755068
57	Increased hepatocellular lipid droplets (HP:0006565)	2.15411287
58	Large for gestational age (HP:0001520)	2.14789229
59	Increased IgM level (HP:0003496)	2.13366545
60	Hypoproteinemia (HP:0003075)	2.10517385
61	Renal cortical cysts (HP:0000803)	2.09648036
62	Abnormal drinking behavior (HP:0030082)	2.08613369
63	Polydipsia (HP:0001959)	2.08613369
64	Inability to walk (HP:0002540)	2.02004515
65	Optic neuritis (HP:0100653)	2.01369671
66	Retrobulbar optic neuritis (HP:0100654)	2.01369671
67	Decreased central vision (HP:0007663)	2.01282652
68	Granulocytopenia (HP:0001913)	2.01057359
69	3-Methylglutaconic aciduria (HP:0003535)	1.98624749
70	Leukocytosis (HP:0001974)	1.98456202
71	Methylmalonic aciduria (HP:0012120)	1.98237027
72	Clubbing of toes (HP:0100760)	1.97802607
73	Methylmalonic acidemia (HP:0002912)	1.97614355
74	Medial flaring of the eyebrow (HP:0010747)	1.97016218
75	Abnormality of the ileum (HP:0001549)	1.95526208
76	Sclerocornea (HP:0000647)	1.94483026
77	Male pseudohermaphroditism (HP:0000037)	1.91260400
78	Meckel diverticulum (HP:0002245)	1.89449476
79	Furrowed tongue (HP:0000221)	1.88858006
80	Bile duct proliferation (HP:0001408)	1.88334724
81	Abnormal biliary tract physiology (HP:0012439)	1.88334724
82	Febrile seizures (HP:0002373)	1.86232385
83	Recurrent fungal infections (HP:0002841)	1.83221110
84	Abnormality of pyrimidine metabolism (HP:0004353)	1.81827663
85	Polyuria (HP:0000103)	1.80051977
86	Bony spicule pigmentary retinopathy (HP:0007737)	1.77640807
87	Renal Fanconi syndrome (HP:0001994)	1.77148213
88	Anencephaly (HP:0002323)	1.76527819
89	Hypothermia (HP:0002045)	1.74188392
90	Abnormal respiratory motile cilium morphology (HP:0005938)	1.73684235
91	Abnormal respiratory epithelium morphology (HP:0012253)	1.73684235
92	Mitochondrial inheritance (HP:0001427)	1.73487259
93	Abnormality of the pons (HP:0007361)	1.73145250
94	Congenital, generalized hypertrichosis (HP:0004540)	1.72945043
95	Keratoconus (HP:0000563)	1.72583796
96	Increased corneal curvature (HP:0100692)	1.72583796
97	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.69878105
98	Tubular atrophy (HP:0000092)	1.69592663
99	Ketosis (HP:0001946)	1.69480038
100	Abnormal ciliary motility (HP:0012262)	1.67696021

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	5.21669487
2	TXK	4.35077726
3	FRK	4.17855093
4	TLK1	3.72874169
5	MAP4K1	3.67485861
6	ZAK	3.57542861
7	ADRBK2	3.23882602
8	GRK1	2.43364394
9	NLK	2.40676180
10	TNIK	2.22490815
11	TNK2	2.21595908
12	BMPR1B	1.79195879
13	PINK1	1.72033525
14	MAP2K7	1.60644923
15	WNK3	1.58006533
16	VRK1	1.50444846
17	MAPK13	1.49710062
18	INSRR	1.46733413
19	MAP3K4	1.45530082
20	ZAP70	1.36907717
21	CAMKK2	1.32441149
22	MARK3	1.32156111
23	NUAK1	1.29818755
24	CSNK1G1	1.28202785
25	CSNK1G3	1.25083602
26	WNK4	1.21969359
27	MAP4K2	1.20816442
28	ITK	1.18283207
29	CSNK1G2	1.17137535
30	CSNK1A1L	1.16982234
31	PRKCQ	1.14829763
32	SYK	1.14137714
33	CASK	1.11700279
34	IKBKE	0.98850985
35	TYRO3	0.96818266
36	SGK2	0.95824063
37	TEC	0.95464843
38	NTRK2	0.95235402
39	DYRK2	0.92538251
40	BTK	0.86822244
41	PAK3	0.83916644
42	ACVR1B	0.82908678
43	FES	0.81441073
44	SGK223	0.79483834
45	SGK494	0.79483834
46	GRK7	0.79331528
47	FGFR2	0.76868636
48	IKBKB	0.74501831
49	LYN	0.74481653
50	DYRK3	0.72618637
51	ADRBK1	0.72106787
52	PRKCG	0.66739588
53	EPHA4	0.65841273
54	LCK	0.65083574
55	MAP3K9	0.63752824
56	SIK2	0.61290401
57	BCKDK	0.60759157
58	STK39	0.60465464
59	STK16	0.55161841
60	CSNK1A1	0.55150052
61	PKN1	0.52789704
62	RPS6KA5	0.50669258
63	EIF2AK3	0.49839851
64	MST4	0.49525174
65	PRKCE	0.48348419
66	SGK1	0.48194539
67	HCK	0.48166841
68	PLK2	0.47659599
69	BLK	0.47236082
70	CSK	0.45897358
71	GRK6	0.44857866
72	STK11	0.43582198
73	PIM1	0.42702820
74	SGK3	0.41710015
75	KIT	0.41508186
76	CAMK4	0.41306170
77	OXSR1	0.40721376
78	RPS6KA4	0.38787216
79	TGFBR1	0.38423118
80	PTK2B	0.38065356
81	DAPK2	0.37588317
82	PRKACA	0.35421152
83	NTRK3	0.34950622
84	CAMK1	0.33699397
85	VRK2	0.33577491
86	CAMK2A	0.33200277
87	JAK1	0.32868827
88	CSNK1D	0.32214106
89	MKNK2	0.31658285
90	CAMKK1	0.31460948
91	NEK2	0.30188931
92	MAP2K6	0.29494179
93	PRKCH	0.28729301
94	PRKCA	0.27622801
95	PIK3CA	0.27541459
96	PASK	0.25724207
97	PRKCB	0.25297186
98	PLK4	0.24115266
99	INSR	0.22190819
100	PIK3CG	0.22036779

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.61959845
2	Primary immunodeficiency_Homo sapiens_hsa05340	3.43287311
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.41153951
4	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.38537691
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.17109804
6	Olfactory transduction_Homo sapiens_hsa04740	2.04600371
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.04523239
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.00541845
9	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.90987991
10	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.84893782
11	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.81563813
12	Nicotine addiction_Homo sapiens_hsa05033	1.80222452
13	Allograft rejection_Homo sapiens_hsa05330	1.77322046
14	Graft-versus-host disease_Homo sapiens_hsa05332	1.69486793
15	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.67770851
16	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.65955818
17	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.53968882
18	Parkinsons disease_Homo sapiens_hsa05012	1.50567690
19	Butanoate metabolism_Homo sapiens_hsa00650	1.50041810
20	Ether lipid metabolism_Homo sapiens_hsa00565	1.47064517
21	Basal transcription factors_Homo sapiens_hsa03022	1.43126229
22	Morphine addiction_Homo sapiens_hsa05032	1.41893709
23	Tryptophan metabolism_Homo sapiens_hsa00380	1.40909308
24	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.40731716
25	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.37967629
26	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.37700162
27	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.35907716
28	Asthma_Homo sapiens_hsa05310	1.35293124
29	Fanconi anemia pathway_Homo sapiens_hsa03460	1.34546678
30	Homologous recombination_Homo sapiens_hsa03440	1.33341111
31	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.32227719
32	Type I diabetes mellitus_Homo sapiens_hsa04940	1.24515338
33	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.23849265
34	Taste transduction_Homo sapiens_hsa04742	1.21546206
35	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.21219230
36	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.15109466
37	Alzheimers disease_Homo sapiens_hsa05010	1.11918144
38	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.11776490
39	RNA polymerase_Homo sapiens_hsa03020	1.08384320
40	Selenocompound metabolism_Homo sapiens_hsa00450	1.05316862
41	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.04352665
42	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.04039828
43	Circadian entrainment_Homo sapiens_hsa04713	1.00841393
44	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.99894985
45	Protein export_Homo sapiens_hsa03060	0.95884509
46	Serotonergic synapse_Homo sapiens_hsa04726	0.95835410
47	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.94708861
48	Caffeine metabolism_Homo sapiens_hsa00232	0.92397233
49	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.91472509
50	Peroxisome_Homo sapiens_hsa04146	0.89224194
51	GABAergic synapse_Homo sapiens_hsa04727	0.88176924
52	Ribosome_Homo sapiens_hsa03010	0.86813069
53	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.85988667
54	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.84522413
55	Cardiac muscle contraction_Homo sapiens_hsa04260	0.83772368
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.83539656
57	Glutamatergic synapse_Homo sapiens_hsa04724	0.83184063
58	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.82825107
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.81627475
60	Calcium signaling pathway_Homo sapiens_hsa04020	0.80443762
61	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.80155967
62	Collecting duct acid secretion_Homo sapiens_hsa04966	0.79607814
63	RNA degradation_Homo sapiens_hsa03018	0.79402918
64	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.76952396
65	Measles_Homo sapiens_hsa05162	0.75179371
66	Antigen processing and presentation_Homo sapiens_hsa04612	0.74602188
67	Retinol metabolism_Homo sapiens_hsa00830	0.73595804
68	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.73523773
69	Insulin secretion_Homo sapiens_hsa04911	0.73194054
70	Huntingtons disease_Homo sapiens_hsa05016	0.72576327
71	ABC transporters_Homo sapiens_hsa02010	0.72349791
72	Glycerolipid metabolism_Homo sapiens_hsa00561	0.72156326
73	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.70454339
74	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.69446714
75	Type II diabetes mellitus_Homo sapiens_hsa04930	0.69202363
76	Propanoate metabolism_Homo sapiens_hsa00640	0.65808187
77	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.65242779
78	Malaria_Homo sapiens_hsa05144	0.65172132
79	Regulation of autophagy_Homo sapiens_hsa04140	0.64805296
80	Rheumatoid arthritis_Homo sapiens_hsa05323	0.64295378
81	Salivary secretion_Homo sapiens_hsa04970	0.63342325
82	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.62998188
83	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.58178975
84	Dopaminergic synapse_Homo sapiens_hsa04728	0.56340443
85	Proteasome_Homo sapiens_hsa03050	0.55867989
86	Renin secretion_Homo sapiens_hsa04924	0.55589714
87	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.54055228
88	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.52864282
89	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.52550757
90	One carbon pool by folate_Homo sapiens_hsa00670	0.52509306
91	Cholinergic synapse_Homo sapiens_hsa04725	0.52032869
92	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.45005790
93	Amphetamine addiction_Homo sapiens_hsa05031	0.44336874
94	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.43760429
95	Gastric acid secretion_Homo sapiens_hsa04971	0.43565096
96	Ras signaling pathway_Homo sapiens_hsa04014	0.43246219
97	Alcoholism_Homo sapiens_hsa05034	0.42206734
98	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.41701978
99	cAMP signaling pathway_Homo sapiens_hsa04024	0.41617462
100	MAPK signaling pathway_Homo sapiens_hsa04010	0.37859241

BCORP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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