BCR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)5.56108244
2negative regulation of erythrocyte differentiation (GO:0045647)5.55079905
3synaptic vesicle maturation (GO:0016188)5.40141721
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.34425098
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.31656820
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.98854997
7vocalization behavior (GO:0071625)4.98404282
8regulation of synapse structural plasticity (GO:0051823)4.93208341
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.57579329
10layer formation in cerebral cortex (GO:0021819)4.53277418
11prepulse inhibition (GO:0060134)4.51370292
12regulation of long-term neuronal synaptic plasticity (GO:0048169)4.43444353
13regulation of glutamate receptor signaling pathway (GO:1900449)4.42750291
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.31649855
15dendritic spine morphogenesis (GO:0060997)4.31532253
16regulation of neuronal synaptic plasticity (GO:0048168)4.23652469
17synaptic vesicle exocytosis (GO:0016079)4.18570489
18regulation of synaptic vesicle exocytosis (GO:2000300)4.05276370
19exploration behavior (GO:0035640)3.98707165
20neurotransmitter secretion (GO:0007269)3.94769047
21regulation of dendritic spine morphogenesis (GO:0061001)3.91496063
22auditory behavior (GO:0031223)3.89072687
23glutamate secretion (GO:0014047)3.84274668
24neurotransmitter-gated ion channel clustering (GO:0072578)3.83299650
25membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.80050900
26protein localization to synapse (GO:0035418)3.78466803
27positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.75537315
28G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.74215540
29ionotropic glutamate receptor signaling pathway (GO:0035235)3.74108948
30positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.71926840
31adherens junction assembly (GO:0034333)3.67969826
32activation of protein kinase A activity (GO:0034199)3.65757830
33positive regulation of synaptic transmission, GABAergic (GO:0032230)3.64444389
34adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.62168539
35adenosine receptor signaling pathway (GO:0001973)3.61652560
36synaptic transmission, dopaminergic (GO:0001963)3.60210025
37dopamine receptor signaling pathway (GO:0007212)3.59859233
38* neuromuscular process controlling balance (GO:0050885)3.58977703
39gamma-aminobutyric acid transport (GO:0015812)3.56147563
40epithelial cell differentiation involved in prostate gland development (GO:0060742)3.55493487
41regulation of synaptic vesicle transport (GO:1902803)3.54022756
42sodium ion export (GO:0071436)3.46218076
43negative regulation of cytosolic calcium ion concentration (GO:0051481)3.45971302
44long-term memory (GO:0007616)3.44693262
45striatum development (GO:0021756)3.43559812
46focal adhesion assembly (GO:0048041)3.42265612
47cell-substrate adherens junction assembly (GO:0007045)3.42265612
48hemidesmosome assembly (GO:0031581)3.41418661
49positive regulation of membrane potential (GO:0045838)3.40394301
50regulation of female receptivity (GO:0045924)3.38769066
51regulation of excitatory postsynaptic membrane potential (GO:0060079)3.38440317
52apoptotic process involved in morphogenesis (GO:0060561)3.38225145
53neuron-neuron synaptic transmission (GO:0007270)3.36336924
54synaptic transmission, glutamatergic (GO:0035249)3.35705429
55response to auditory stimulus (GO:0010996)3.35460426
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.34596404
57planar cell polarity pathway involved in neural tube closure (GO:0090179)3.34093725
58cell-substrate junction assembly (GO:0007044)3.34011991
59cellular potassium ion homeostasis (GO:0030007)3.33073634
60positive regulation of synapse maturation (GO:0090129)3.27532735
61regulation of synaptic plasticity (GO:0048167)3.26011652
62regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.25976119
63positive regulation of neurotransmitter transport (GO:0051590)3.23291035
64peptidyl-tyrosine autophosphorylation (GO:0038083)3.20437525
65cerebellar granule cell differentiation (GO:0021707)3.20146087
66histone H3-K36 demethylation (GO:0070544)3.19567847
67regulation of postsynaptic membrane potential (GO:0060078)3.18756201
68neuronal ion channel clustering (GO:0045161)3.15860807
69regulation of synaptic transmission, glutamatergic (GO:0051966)3.15652776
70glutamate receptor signaling pathway (GO:0007215)3.15560011
71amino acid import (GO:0043090)3.13689200
72positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.11956481
73neuron cell-cell adhesion (GO:0007158)3.11405486
74proline transport (GO:0015824)3.09975839
75negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.09643186
76L-amino acid import (GO:0043092)3.09005196
77mating behavior (GO:0007617)3.08990065
78protein-DNA complex disassembly (GO:0032986)3.08273699
79nucleosome disassembly (GO:0006337)3.08273699
80response to amphetamine (GO:0001975)3.07528586
81transmission of nerve impulse (GO:0019226)3.07312939
82mannose metabolic process (GO:0006013)3.06811455
83dendritic spine organization (GO:0097061)3.06491832
84negative regulation of histone methylation (GO:0031061)3.06484304
85regulation of ARF protein signal transduction (GO:0032012)3.06441590
86behavioral response to cocaine (GO:0048148)3.06059334
87positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.05283033
88cytoskeletal anchoring at plasma membrane (GO:0007016)3.05266046
89neuronal action potential propagation (GO:0019227)3.05145383
90regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.04651500
91glycine transport (GO:0015816)3.03937808
92atrioventricular valve morphogenesis (GO:0003181)3.02082809
93regulation of NFAT protein import into nucleus (GO:0051532)3.00242910
94neurotransmitter transport (GO:0006836)2.99766170
95activation of Rac GTPase activity (GO:0032863)2.97895236
96dendrite morphogenesis (GO:0048813)2.97888720
97regulation of dendritic spine development (GO:0060998)2.94731451
98regulation of nucleobase-containing compound transport (GO:0032239)2.93353743
99positive regulation of dendritic spine morphogenesis (GO:0061003)2.93300514
100cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.93076916
101cAMP catabolic process (GO:0006198)2.92722257
102regulation of neurotransmitter levels (GO:0001505)2.92458924
103cellular protein complex localization (GO:0034629)2.91904825
104cerebellar Purkinje cell layer development (GO:0021680)2.90968385
105positive regulation of neurotransmitter secretion (GO:0001956)2.90854924
106behavioral fear response (GO:0001662)2.90714375
107behavioral defense response (GO:0002209)2.90714375
108long-term synaptic potentiation (GO:0060291)2.89315391
109female mating behavior (GO:0060180)2.88830943
110cell communication by electrical coupling (GO:0010644)2.87840463
111neural tube development (GO:0021915)2.87572844
112negative regulation of myotube differentiation (GO:0010832)2.87442126
113membrane hyperpolarization (GO:0060081)2.87323735
114cellular response to epidermal growth factor stimulus (GO:0071364)2.86722656
115negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.86606799
116response to histamine (GO:0034776)2.84242909
117semaphorin-plexin signaling pathway (GO:0071526)2.83809034
118protein complex localization (GO:0031503)2.83609300
119neuron recognition (GO:0008038)2.82765351
120visual learning (GO:0008542)2.81241296
121regulation of early endosome to late endosome transport (GO:2000641)2.78732780
122positive regulation of dendritic spine development (GO:0060999)2.77494704
123cell migration in hindbrain (GO:0021535)2.77342567
124regulation of RNA export from nucleus (GO:0046831)2.76239998
125regulation of ARF GTPase activity (GO:0032312)2.75176759
126mechanosensory behavior (GO:0007638)2.74550348
127neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.74117962
128DNA unwinding involved in DNA replication (GO:0006268)2.73776552
129membrane depolarization during action potential (GO:0086010)2.72908879
130desmosome organization (GO:0002934)2.72745141
131regulation of mammary gland epithelial cell proliferation (GO:0033599)2.72677204
132positive regulation of synaptic transmission (GO:0050806)2.72645165
133learning (GO:0007612)2.71873284
134membrane depolarization (GO:0051899)2.71647655
135vesicle transport along microtubule (GO:0047496)2.70721611
136regulation of Rap GTPase activity (GO:0032317)2.70292602
137protein localization to endosome (GO:0036010)2.70119717
138signal complex assembly (GO:0007172)2.69867105
139regulation of glucose import in response to insulin stimulus (GO:2001273)2.69646355
140regulation of synaptic transmission, GABAergic (GO:0032228)2.67839991
141* neuromuscular process (GO:0050905)2.67706002
142response to epidermal growth factor (GO:0070849)2.66881626
143establishment of apical/basal cell polarity (GO:0035089)2.64970250
144glucocorticoid receptor signaling pathway (GO:0042921)2.64223133
145insulin-like growth factor receptor signaling pathway (GO:0048009)2.61705983
146positive regulation of Rap GTPase activity (GO:0032854)2.58640437
147peptidyl-threonine modification (GO:0018210)2.57559114
148peptidyl-threonine phosphorylation (GO:0018107)2.54846623
149histone lysine demethylation (GO:0070076)2.54831228
150cell volume homeostasis (GO:0006884)2.51236411
151negative regulation of cell size (GO:0045792)2.50082899
1523-UTR-mediated mRNA stabilization (GO:0070935)2.49244500
153regulation of histone H3-K27 methylation (GO:0061085)2.47968864
154positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.47094416
155protein targeting to plasma membrane (GO:0072661)2.47050475
156cell-cell junction maintenance (GO:0045217)2.40112902
157intracellular estrogen receptor signaling pathway (GO:0030520)2.38652049
158heterochromatin organization (GO:0070828)2.37434751
159histone demethylation (GO:0016577)2.37238630
160RNA stabilization (GO:0043489)2.36774517
161mRNA stabilization (GO:0048255)2.36774517
162convergent extension (GO:0060026)2.35856287
163embryonic eye morphogenesis (GO:0048048)2.34129660
164response to muramyl dipeptide (GO:0032495)2.33356579
165ear development (GO:0043583)2.30071552
166regulation of chromatin binding (GO:0035561)2.29291478
167positive regulation of blood vessel endothelial cell migration (GO:0043536)2.28899137
168negative regulation of cell fate specification (GO:0009996)2.26379531
169histone deacetylation (GO:0016575)2.23493037
170epithelial cell fate commitment (GO:0072148)2.22274872
171cortical actin cytoskeleton organization (GO:0030866)2.21756609
172histone H4 deacetylation (GO:0070933)2.21501604
173negative regulation of fatty acid transport (GO:2000192)2.21319873
174positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.20972079
175negative regulation of striated muscle cell differentiation (GO:0051154)2.20822907
176pre-miRNA processing (GO:0031054)2.20410174
177spliceosomal tri-snRNP complex assembly (GO:0000244)2.20142832
178stress fiber assembly (GO:0043149)2.19889222
179maternal placenta development (GO:0001893)2.19336828
180chromatin silencing (GO:0006342)2.19236261
181regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.18560980
182Peyers patch development (GO:0048541)2.15790795
183mucosal-associated lymphoid tissue development (GO:0048537)2.15790795

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.74277491
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.61956964
3RARB_27405468_Chip-Seq_BRAIN_Mouse3.24459574
4MYC_22102868_ChIP-Seq_BL_Human3.22163551
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.80743829
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.74430174
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.73941089
8DROSHA_22980978_ChIP-Seq_HELA_Human2.70017787
9EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.68523017
10KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.68379186
11VDR_21846776_ChIP-Seq_THP-1_Human2.67197851
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.65221083
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.58798430
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.58798430
15TCF7_22412390_ChIP-Seq_EML_Mouse2.55105639
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.51590842
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.47975166
18* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.40056596
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.38966924
20ELK3_25401928_ChIP-Seq_HUVEC_Human2.38552451
21REST_21632747_ChIP-Seq_MESCs_Mouse2.37194335
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.31885529
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.29265375
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.27437190
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.21921762
26GBX2_23144817_ChIP-Seq_PC3_Human2.21557400
27EZH2_27304074_Chip-Seq_ESCs_Mouse2.19976694
28* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.15363104
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.12444583
30* EZH2_27294783_Chip-Seq_ESCs_Mouse2.11708969
31* RNF2_27304074_Chip-Seq_ESCs_Mouse2.06579712
32* RACK7_27058665_Chip-Seq_MCF-7_Human2.02454397
33REST_18959480_ChIP-ChIP_MESCs_Mouse2.00039518
34* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.99752959
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.94319820
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.92250930
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.85181874
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.80788202
39CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77123549
40* KDM2B_26808549_Chip-Seq_K562_Human1.76316225
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.73160585
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.70784743
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70624466
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.69525821
45ZFP281_18757296_ChIP-ChIP_E14_Mouse1.69069114
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.67116084
47AR_21572438_ChIP-Seq_LNCaP_Human1.66516821
48ZNF263_19887448_ChIP-Seq_K562_Human1.62331719
49E2F7_22180533_ChIP-Seq_HELA_Human1.59073844
50DNAJC2_21179169_ChIP-ChIP_NT2_Human1.58387607
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57508948
52UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.53219987
53* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.50465606
54VDR_24763502_ChIP-Seq_THP-1_Human1.49425216
55* SMC4_20622854_ChIP-Seq_HELA_Human1.49344217
56* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.49240266
57P68_20966046_ChIP-Seq_HELA_Human1.49031911
58* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.48808924
59* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.48049732
60* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.46629614
61SA1_27219007_Chip-Seq_ERYTHROID_Human1.46014183
62SCL_19346495_ChIP-Seq_HPC-7_Human1.45798690
63* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.44501364
64* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.43116221
65CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.41103130
66* RING1B_27294783_Chip-Seq_ESCs_Mouse1.38267572
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37466867
68NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.35753006
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.35644167
70* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35620657
71TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34179219
72DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.34076051
73CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.32336139
74RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.31678780
75* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.29164599
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27506365
77* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.25832374
78* RING1B_27294783_Chip-Seq_NPCs_Mouse1.25363440
79* UTX_26944678_Chip-Seq_JUKART_Human1.25341114
80TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.25304233
81AR_19668381_ChIP-Seq_PC3_Human1.25205515
82RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.24192837
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23390350
84RUNX1_27514584_Chip-Seq_MCF-7_Human1.22483261
85TET1_21451524_ChIP-Seq_MESCs_Mouse1.21660994
86CLOCK_20551151_ChIP-Seq_293T_Human1.21604508
87SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.19722467
88* NCOR1_26117541_ChIP-Seq_K562_Human1.18924793
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18911967
90* MAF_26560356_Chip-Seq_TH1_Human1.18701605
91NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17623757
92* GATA1_19941827_ChIP-Seq_MEL_Mouse1.17463116
93SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.17278446
94PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16540550
95* SOX2_21211035_ChIP-Seq_LN229_Gbm1.15946709
96SOX9_24532713_ChIP-Seq_HFSC_Mouse1.14528734
97TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14365755
98AHR_22903824_ChIP-Seq_MCF-7_Human1.14130867
99ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.13994017
100SMAD4_21799915_ChIP-Seq_A2780_Human1.12626142
101KDM2B_26808549_Chip-Seq_DND41_Human1.12486580
102CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11613891
103CTCF_27219007_Chip-Seq_Bcells_Human1.11596693
104* KDM2B_26808549_Chip-Seq_JURKAT_Human1.10841757
105* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10417968
106SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09106936
107* RUNX1_22412390_ChIP-Seq_EML_Mouse1.09075700
108SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08737171
109MAF_26560356_Chip-Seq_TH2_Human1.08441506
110KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.05677058
111KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.05677058
112KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.05677058
113TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05623476
114EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.04971845
115POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04894854
116ARNT_22903824_ChIP-Seq_MCF-7_Human1.04510348
117SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03752006
118ESR1_20079471_ChIP-ChIP_T-47D_Human1.03501176
119NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03016254
120ZNF274_21170338_ChIP-Seq_K562_Hela1.02447604
121LXR_22292898_ChIP-Seq_THP-1_Human1.02324877
122VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01715470
123ESR2_21235772_ChIP-Seq_MCF-7_Human1.01059290
124GATA1_19941826_ChIP-Seq_K562_Human1.00474540
125* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00347283
126PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99968450
127* SMAD3_21741376_ChIP-Seq_HESCs_Human0.99930739
128TP63_22573176_ChIP-Seq_HFKS_Human0.98933588
129* SMAD4_21741376_ChIP-Seq_HESCs_Human0.98749016
130CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98583977
131DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98534569
132GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98177850
133CREB1_26743006_Chip-Seq_LNCaP_Human0.98052209
134ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97913899
135SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.97451161
136TET1_21490601_ChIP-Seq_MESCs_Mouse0.97186124
137P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96915144
138PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.95956758
139STAT3_23295773_ChIP-Seq_U87_Human0.95886953
140MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.95596009
141KAP1_27257070_Chip-Seq_ESCs_Mouse0.95210062
142SMAD3_21741376_ChIP-Seq_EPCs_Human0.94960372
143POU5F1_16518401_ChIP-PET_MESCs_Mouse0.94868756
144* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.93020857
145* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92656124
146OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92309766
147RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91709685
148RXR_22108803_ChIP-Seq_LS180_Human0.91429288
149PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.90992924
150RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.90610733
151CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90561418
152SMAD3_21741376_ChIP-Seq_ESCs_Human0.89056908
153CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88833792
154SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88613576
155* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.88259219
156* KLF4_19829295_ChIP-Seq_ESCs_Human0.88169652
157* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87648362
158ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.87291848
159NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.86019183
160* ISL1_27105846_Chip-Seq_CPCs_Mouse0.85393157
161MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85388219
162* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.85050454
163CDX2_19796622_ChIP-Seq_MESCs_Mouse0.84066750
164* FOXA2_19822575_ChIP-Seq_HepG2_Human0.83183483
165CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83064746
166* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81637145
167* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.81221468
168TP53_16413492_ChIP-PET_HCT116_Human0.81220804

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.47248631
2MP0002822_catalepsy5.99455338
3MP0003635_abnormal_synaptic_transmissio4.01768945
4MP0004270_analgesia3.43882843
5MP0003880_abnormal_central_pattern3.39164028
6MP0002063_abnormal_learning/memory/cond3.31839944
7MP0009745_abnormal_behavioral_response3.24764230
8MP0001849_ear_inflammation3.20287064
9MP0002909_abnormal_adrenal_gland2.85638555
10MP0005076_abnormal_cell_differentiation2.74930958
11MP0000579_abnormal_nail_morphology2.74327550
12MP0002064_seizures2.70916222
13MP0002572_abnormal_emotion/affect_behav2.57304572
14MP0002796_impaired_skin_barrier2.51718286
15MP0009780_abnormal_chondrocyte_physiolo2.49979821
16MP0002396_abnormal_hematopoietic_system2.43363796
17MP0003566_abnormal_cell_adhesion2.39239136
18MP0009278_abnormal_bone_marrow2.38912991
19MP0005423_abnormal_somatic_nervous2.38757445
20MP0009046_muscle_twitch2.34730617
21MP0001968_abnormal_touch/_nociception2.31716228
22MP0001486_abnormal_startle_reflex2.30828181
23MP0000566_synostosis2.18860892
24MP0002734_abnormal_mechanical_nocicepti2.07574122
25MP0002272_abnormal_nervous_system2.06590498
26MP0004185_abnormal_adipocyte_glucose2.01059465
27MP0003453_abnormal_keratinocyte_physiol1.99111198
28MP0001501_abnormal_sleep_pattern1.89152514
29MP0009672_abnormal_birth_weight1.88084957
30MP0004811_abnormal_neuron_physiology1.79196700
31MP0004858_abnormal_nervous_system1.79099738
32MP0010352_gastrointestinal_tract_polyps1.77908689
33MP0005646_abnormal_pituitary_gland1.77641810
34MP0010234_abnormal_vibrissa_follicle1.77335561
35MP0000678_abnormal_parathyroid_gland1.77039229
36MP0002733_abnormal_thermal_nociception1.74477183
37MP0003283_abnormal_digestive_organ1.71706265
38MP0008961_abnormal_basal_metabolism1.69948831
39MP0002249_abnormal_larynx_morphology1.69152279
40MP0008569_lethality_at_weaning1.68549554
41MP0004808_abnormal_hematopoietic_stem1.68332408
42MP0004885_abnormal_endolymph1.66684019
43MP0002557_abnormal_social/conspecific_i1.65438765
44MP0003329_amyloid_beta_deposits1.65246880
45MP0005666_abnormal_adipose_tissue1.63313951
46MP0001440_abnormal_grooming_behavior1.63002032
47MP0005386_behavior/neurological_phenoty1.62619377
48MP0004924_abnormal_behavior1.62619377
49MP0001970_abnormal_pain_threshold1.61358419
50MP0001730_embryonic_growth_arrest1.57189809
51MP0002736_abnormal_nociception_after1.55584758
52MP0004381_abnormal_hair_follicle1.54368143
53MP0005501_abnormal_skin_physiology1.53786337
54MP0001529_abnormal_vocalization1.53597619
55MP0000013_abnormal_adipose_tissue1.48791185
56MP0008260_abnormal_autophagy1.43439039
57MP0004264_abnormal_extraembryonic_tissu1.41099580
58MP0000955_abnormal_spinal_cord1.39173316
59MP0002184_abnormal_innervation1.39055854
60MP0000778_abnormal_nervous_system1.39016548
61MP0001177_atelectasis1.38651914
62MP0003091_abnormal_cell_migration1.35556764
63MP0002067_abnormal_sensory_capabilities1.34301072
64MP0003172_abnormal_lysosome_physiology1.33992229
65MP0003879_abnormal_hair_cell1.31587425
66MP0005167_abnormal_blood-brain_barrier1.31534883
67MP0002735_abnormal_chemical_nociception1.26751620
68MP0003633_abnormal_nervous_system1.25578190
69MP0001984_abnormal_olfaction1.25397103
70MP0003075_altered_response_to1.25309010
71MP0004947_skin_inflammation1.23544366
72MP0005464_abnormal_platelet_physiology1.22619815
73MP0002066_abnormal_motor_capabilities/c1.22160531
74MP0005375_adipose_tissue_phenotype1.20108407
75MP0001915_intracranial_hemorrhage1.20101297
76MP0003941_abnormal_skin_development1.19650207
77MP0003787_abnormal_imprinting1.19273572
78MP0010368_abnormal_lymphatic_system1.18589838
79MP0005409_darkened_coat_color1.17857982
80MP0002882_abnormal_neuron_morphology1.17679168
81MP0008874_decreased_physiological_sensi1.16964430
82MP0003123_paternal_imprinting1.15961776
83MP0003763_abnormal_thymus_physiology1.15607820
84MP0000569_abnormal_digit_pigmentation1.14636913
85MP0002060_abnormal_skin_morphology1.13298013
86MP0005645_abnormal_hypothalamus_physiol1.12649954
87MP0002086_abnormal_extraembryonic_tissu1.12081225
88MP0000462_abnormal_digestive_system1.11049571
89MP0001502_abnormal_circadian_rhythm1.09197946
90MP0001216_abnormal_epidermal_layer1.08421585
91MP0005187_abnormal_penis_morphology1.08114057
92MP0000350_abnormal_cell_proliferation1.07683461
93MP0000467_abnormal_esophagus_morphology1.06879710
94MP0005621_abnormal_cell_physiology1.06514036
95MP0002877_abnormal_melanocyte_morpholog1.05893015
96MP0004782_abnormal_surfactant_physiolog1.05822074
97MP0003984_embryonic_growth_retardation1.05718325
98MP0002098_abnormal_vibrissa_morphology1.04653335
99MP0002152_abnormal_brain_morphology1.04136119
100MP0001672_abnormal_embryogenesis/_devel1.03168530
101MP0005380_embryogenesis_phenotype1.03168530
102MP0000377_abnormal_hair_follicle1.03101506
103MP0000762_abnormal_tongue_morphology1.01394212
104MP0002069_abnormal_eating/drinking_beha1.00047781
105MP0010030_abnormal_orbit_morphology0.99687899
106MP0004085_abnormal_heartbeat0.99438198
107MP0004272_abnormal_basement_membrane0.99137906
108MP0002088_abnormal_embryonic_growth/wei0.98581586
109MP0009931_abnormal_skin_appearance0.97789241
110MP0003631_nervous_system_phenotype0.96974459
111MP0000428_abnormal_craniofacial_morphol0.96557647
112MP0008872_abnormal_physiological_respon0.96346087
113MP0002084_abnormal_developmental_patter0.95789401
114MP0002080_prenatal_lethality0.95402244
115MP0003122_maternal_imprinting0.94508292
116MP0002234_abnormal_pharynx_morphology0.93686903
117MP0005394_taste/olfaction_phenotype0.92057074
118MP0005499_abnormal_olfactory_system0.92057074
119MP0002925_abnormal_cardiovascular_devel0.90945631
120MP0010630_abnormal_cardiac_muscle0.90748224
121MP0000703_abnormal_thymus_morphology0.90449252
122MP0003115_abnormal_respiratory_system0.90423736
123MP0002085_abnormal_embryonic_tissue0.89489372
124MP0005623_abnormal_meninges_morphology0.88026405
125MP0002090_abnormal_vision0.87453925
126MP0001188_hyperpigmentation0.86853694
127MP0010771_integument_phenotype0.86574634
128MP0005535_abnormal_body_temperature0.85558730
129MP0009703_decreased_birth_body0.85020494
130MP0005670_abnormal_white_adipose0.84829273
131MP0003705_abnormal_hypodermis_morpholog0.83651765
132MP0004233_abnormal_muscle_weight0.82189512
133MP0002009_preneoplasia0.78513861
134MP0005023_abnormal_wound_healing0.78212868
135MP0000534_abnormal_ureter_morphology0.78113942
136MP0000003_abnormal_adipose_tissue0.77911510
137MP0003690_abnormal_glial_cell0.77295316
138MP0000681_abnormal_thyroid_gland0.77137028
139MP0000631_abnormal_neuroendocrine_gland0.76898723
140MP0006276_abnormal_autonomic_nervous0.76800101
141MP0005058_abnormal_lysosome_morphology0.75151695
142MP0001545_abnormal_hematopoietic_system0.73429110
143MP0005397_hematopoietic_system_phenotyp0.73429110
144MP0003111_abnormal_nucleus_morphology0.72562004
145MP0003300_gastrointestinal_ulcer0.71773533
146MP0003935_abnormal_craniofacial_develop0.70264805
147MP0000751_myopathy0.69810841
148* MP0001784_abnormal_fluid_regulation0.69194837
149MP0008004_abnormal_stomach_pH0.67313218
150MP0003385_abnormal_body_wall0.67067740
151MP0001851_eye_inflammation0.67028056
152MP0003045_fibrosis0.66767849
153MP0003634_abnormal_glial_cell0.63412876
154MP0000537_abnormal_urethra_morphology0.63276511
155MP0002229_neurodegeneration0.61696378
156MP0001664_abnormal_digestion0.61317527
157MP0003632_abnormal_nervous_system0.61035726
158MP0001905_abnormal_dopamine_level0.60596985
159MP0000604_amyloidosis0.59852064
160MP0005551_abnormal_eye_electrophysiolog0.58822891
161MP0005248_abnormal_Harderian_gland0.58511503
162MP0004043_abnormal_pH_regulation0.58361055
163MP0001943_abnormal_respiration0.58117358
164MP0003861_abnormal_nervous_system0.56929354
165MP0004130_abnormal_muscle_cell0.52746130
166MP0001299_abnormal_eye_distance/0.51327482
167MP0005166_decreased_susceptibility_to0.50719110
168MP0010769_abnormal_survival0.49553466
169MP0003303_peritoneal_inflammation0.48938299
170MP0002089_abnormal_postnatal_growth/wei0.48501101
171MP0010770_preweaning_lethality0.47405628
172MP0002082_postnatal_lethality0.47405628
173MP0002078_abnormal_glucose_homeostasis0.47288551

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.98718464
2Focal motor seizures (HP:0011153)5.63874851
3Focal seizures (HP:0007359)4.68631451
4Visual hallucinations (HP:0002367)4.00296341
5Action tremor (HP:0002345)3.59184393
6Torticollis (HP:0000473)3.49327061
7Broad face (HP:0000283)3.32433639
8Poor eye contact (HP:0000817)3.31544868
9Papilledema (HP:0001085)3.23858889
10Ankle clonus (HP:0011448)3.23729635
11Abnormal social behavior (HP:0012433)3.23589782
12Impaired social interactions (HP:0000735)3.23589782
13Depression (HP:0000716)3.22893849
14Resting tremor (HP:0002322)3.19964759
15Impaired vibration sensation in the lower limbs (HP:0002166)3.16535584
16Annular pancreas (HP:0001734)3.12293310
17Supranuclear gaze palsy (HP:0000605)3.08282684
18Abnormality of the lower motor neuron (HP:0002366)3.03605175
19Focal dystonia (HP:0004373)3.00744110
20Anxiety (HP:0000739)3.00006086
21Urinary bladder sphincter dysfunction (HP:0002839)2.93109143
22Epileptic encephalopathy (HP:0200134)2.92919821
23Generalized tonic-clonic seizures (HP:0002069)2.92503737
24Absence seizures (HP:0002121)2.89209919
25Craniofacial dystonia (HP:0012179)2.88843567
26Dysdiadochokinesis (HP:0002075)2.78663442
27Abnormality of the fingertips (HP:0001211)2.74580624
28Postural instability (HP:0002172)2.73571688
29Progressive cerebellar ataxia (HP:0002073)2.72231945
30Hemiplegia (HP:0002301)2.71206176
31Insomnia (HP:0100785)2.69536188
32Megalencephaly (HP:0001355)2.68634873
33Dysmetric saccades (HP:0000641)2.65007848
34Broad-based gait (HP:0002136)2.63467308
35Urethral obstruction (HP:0000796)2.63376842
36Urinary urgency (HP:0000012)2.54600414
37Atonic seizures (HP:0010819)2.54011878
38Truncal ataxia (HP:0002078)2.53001301
39Dialeptic seizures (HP:0011146)2.50856172
40* Pointed chin (HP:0000307)2.49726585
41Amblyopia (HP:0000646)2.49523988
42Febrile seizures (HP:0002373)2.47705880
43Cerebral inclusion bodies (HP:0100314)2.46940938
44Selective tooth agenesis (HP:0001592)2.45567333
45Lower limb amyotrophy (HP:0007210)2.45445459
46Abnormal eating behavior (HP:0100738)2.44261630
47* Ankyloglossia (HP:0010296)2.43520365
48Impaired smooth pursuit (HP:0007772)2.43054388
49Shallow orbits (HP:0000586)2.39959763
50Distal upper limb amyotrophy (HP:0007149)2.39026373
51Upper limb amyotrophy (HP:0009129)2.39026373
52Genetic anticipation (HP:0003743)2.38092310
53Hyperacusis (HP:0010780)2.35032286
54Intention tremor (HP:0002080)2.34208814
55Dysmetria (HP:0001310)2.34113004
56Germ cell neoplasia (HP:0100728)2.32978910
57Bronchomalacia (HP:0002780)2.32524567
58Milia (HP:0001056)2.28022943
59Macroorchidism (HP:0000053)2.27077854
60Spastic gait (HP:0002064)2.25248342
61Abnormality of the salivary glands (HP:0010286)2.22131863
62Insidious onset (HP:0003587)2.20939125
63Termporal pattern (HP:0011008)2.20939125
64Gaze-evoked nystagmus (HP:0000640)2.19570401
65Ventricular fibrillation (HP:0001663)2.19080169
66* Bowel incontinence (HP:0002607)2.18389775
67* Stereotypic behavior (HP:0000733)2.18137148
68Ulnar bowing (HP:0003031)2.17960025
69* Abnormality of oral frenula (HP:0000190)2.16586804
70Bradykinesia (HP:0002067)2.16107440
71EEG with generalized epileptiform discharges (HP:0011198)2.15998206
72Abnormality of the distal phalanx of the thumb (HP:0009617)2.15064304
73Disproportionate tall stature (HP:0001519)2.14977614
74Epileptiform EEG discharges (HP:0011182)2.14816011
75Hypsarrhythmia (HP:0002521)2.14005156
76Neurofibrillary tangles (HP:0002185)2.13619445
77Skull defect (HP:0001362)2.11814532
78Scanning speech (HP:0002168)2.10488995
79Hyperthyroidism (HP:0000836)2.10313111
80Excessive salivation (HP:0003781)2.09855126
81Drooling (HP:0002307)2.09855126
82Hemiparesis (HP:0001269)2.07172076
83Arnold-Chiari malformation (HP:0002308)2.07131195
84Abnormality of ocular smooth pursuit (HP:0000617)2.06139178
85Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.05302769
86Elfin facies (HP:0004428)2.03768202
87Fragile skin (HP:0001030)2.03604773
88Prolonged QT interval (HP:0001657)2.02987834
89Impaired vibratory sensation (HP:0002495)2.02404572
90Mutism (HP:0002300)2.02036859
91Patellar dislocation (HP:0002999)2.00560677
92Status epilepticus (HP:0002133)2.00519007
93Clonus (HP:0002169)2.00362681
94Agitation (HP:0000713)1.99674775
95Obstructive sleep apnea (HP:0002870)1.98081783
96* Abnormal large intestine physiology (HP:0012700)1.97711017
97Neoplasm of the heart (HP:0100544)1.96982991
98Lower limb muscle weakness (HP:0007340)1.96487059
99Lower limb asymmetry (HP:0100559)1.96055430
100Hyperventilation (HP:0002883)1.95393085
101Overriding aorta (HP:0002623)1.95244645
102Abnormality of nail color (HP:0100643)1.95233562
103Long eyelashes (HP:0000527)1.95038698
104Atrioventricular block (HP:0001678)1.91275490
105Abnormality of cochlea (HP:0000375)1.90694146
106Distal lower limb amyotrophy (HP:0008944)1.90445294
107Bundle branch block (HP:0011710)1.89737331
108Limb dystonia (HP:0002451)1.89689334
109Vertebral arch anomaly (HP:0008438)1.88236941
110Premature skin wrinkling (HP:0100678)1.87334295
111Buphthalmos (HP:0000557)1.87088281
112Cellulitis (HP:0100658)1.87009748
113Abnormal EKG (HP:0003115)1.86734096
114Abnormality of the columella (HP:0009929)1.83032742
115Turricephaly (HP:0000262)1.82998127
116Fragile nails (HP:0001808)1.82268532
117Hypercortisolism (HP:0001578)1.80544079
118Mitral valve prolapse (HP:0001634)1.80088577
119Hemangiomatosis (HP:0007461)1.79555588
120Partial duplication of thumb phalanx (HP:0009944)1.78522112
121Neuronal loss in central nervous system (HP:0002529)1.78493575
122Hypoventilation (HP:0002791)1.77556492
123Asymmetry of the thorax (HP:0001555)1.77445205
124Rapidly progressive (HP:0003678)1.76598040
125* Truncus arteriosus (HP:0001660)1.76415445
126Peripheral hypomyelination (HP:0007182)1.76145066
127Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.76047744
128Spinal cord compression (HP:0002176)1.75162740
129Flat acetabular roof (HP:0003180)1.74743996
130Diplopia (HP:0000651)1.74521533
131Abnormality of binocular vision (HP:0011514)1.74521533
132Pili torti (HP:0003777)1.74014305
133Advanced eruption of teeth (HP:0006288)1.73988618
134Incomplete penetrance (HP:0003829)1.73464047
135Visceral angiomatosis (HP:0100761)1.73312209
136Broad distal phalanx of finger (HP:0009836)1.73219273
137Long palpebral fissure (HP:0000637)1.73145209
138Intellectual disability, profound (HP:0002187)1.73107299
139Precocious puberty (HP:0000826)1.72604404
140Aplasia involving bones of the upper limbs (HP:0009823)1.71386067
141Aplasia of the phalanges of the hand (HP:0009802)1.71386067
142Aplasia involving bones of the extremities (HP:0009825)1.71386067
143Deep palmar crease (HP:0006191)1.69964511
144Relative macrocephaly (HP:0004482)1.68900930
145Atrophic scars (HP:0001075)1.68672461
146Back pain (HP:0003418)1.68284284
147Renovascular hypertension (HP:0100817)1.68253361
148Cerebral aneurysm (HP:0004944)1.67740745
149Centrally nucleated skeletal muscle fibers (HP:0003687)1.67165340
150Abnormality of the thoracic spine (HP:0100711)1.66453596
151Prolonged bleeding time (HP:0003010)1.65091186
152Esophageal varix (HP:0002040)1.64490325
153Aplasia cutis congenita (HP:0001057)1.63493647
154Laryngomalacia (HP:0001601)1.62887746
155Split hand (HP:0001171)1.62171610
156Onion bulb formation (HP:0003383)1.59960590
157Ridged nail (HP:0001807)1.58721976
158Sparse scalp hair (HP:0002209)1.58274169
159Heterotopia (HP:0002282)1.57012129
160Nasolacrimal duct obstruction (HP:0000579)1.56891369
161Increased IgE level (HP:0003212)1.56244117
162Renal duplication (HP:0000075)1.54975471
163Colitis (HP:0002583)1.53611732
164Protrusio acetabuli (HP:0003179)1.53091885
165Mitral regurgitation (HP:0001653)1.53060321
166Hammertoe (HP:0001765)1.51085309
167Spina bifida occulta (HP:0003298)1.49854961
168Thickened helices (HP:0000391)1.49614727
169Persistence of primary teeth (HP:0006335)1.49001240
170Trigonocephaly (HP:0000243)1.45393944

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.45036254
2NTRK33.75838287
3SMG13.62622273
4PRKD33.40467102
5CDK123.38247804
6MAP3K93.38056701
7DAPK22.55177907
8KSR22.52493916
9MARK12.46534470
10MINK12.27536968
11CAMKK12.21172648
12MAP3K42.11070301
13TRIB32.07106715
14PAK62.02488562
15NTRK11.97124249
16NTRK21.89807660
17SIK21.84765484
18RIPK11.75442023
19TAOK11.70636629
20MAP3K21.68659476
21KSR11.64535968
22TYRO31.60450604
23FGFR41.59587942
24CDK51.51240094
25RIPK41.48888411
26STK381.31761809
27MTOR1.31615946
28MAP2K41.30449271
29PRKCH1.30168424
30ERN11.23060676
31RET1.22172313
32DAPK11.21137172
33EPHA21.20880712
34PDGFRA1.12003412
35ALK1.10788104
36MARK21.06426893
37PKN21.03752870
38SGK31.02727868
39UHMK11.02509848
40FGFR21.02183360
41EEF2K1.01623534
42LATS20.99932834
43STK110.99142467
44MAP2K70.98798677
45CAMK1D0.96515056
46BRD40.93150052
47SGK2230.92593213
48SGK4940.92593213
49MAPK130.88378682
50MAP3K10.87643575
51SGK20.87122044
52EPHB10.86433054
53FGFR30.84936727
54MAP3K100.84586947
55PRKD20.84195767
56MAP4K10.84154259
57PNCK0.84018071
58MAP3K130.83032380
59CAMK1G0.82656802
60PRKCG0.81911409
61CDK150.80237559
62CDK180.78875995
63TIE10.78671558
64SCYL20.77815296
65LMTK20.77737208
66MAP2K30.77603043
67CDK40.76822561
68IRAK20.76629614
69CDK140.76418299
70PTK2B0.74857164
71CAMK10.74506958
72MAP2K20.73708362
73ICK0.71015261
74BTK0.70892041
75MAP2K10.70308113
76TTN0.69739883
77SGK10.69483602
78RAF10.69375910
79CAMKK20.69295689
80RPS6KB20.69292376
81MAP3K70.69077451
82CDK11A0.69019838
83CDC42BPA0.69009210
84ARAF0.68544668
85PAK30.68167647
86PDPK10.67483422
87DMPK0.67285476
88MAPK120.66676534
89ZAP700.66542998
90MST1R0.65350858
91FER0.63864544
92BMX0.63347117
93PRKCZ0.62054377
94RPS6KA20.61360130
95PDK10.61081413
96MAPK110.60387011
97GRK50.59050112
98CAMK2A0.58612439
99IRAK30.58423866
100RPS6KC10.57859562
101RPS6KL10.57859562
102MAP3K80.57312078
103RPS6KA30.57071311
104PRPF4B0.57060063
105NEK10.55876073
106MET0.55805653
107RPS6KB10.55588707
108PAK40.52754469
109PHKG10.52334798
110PHKG20.52334798
111CDK60.50607472
112CAMK40.50578479
113NEK60.50461729
114BRSK10.49246982
115LRRK20.48903896
116WNK30.48804106
117FRK0.48556297
118DDR20.48020560
119CSNK1G20.47860827
120CAMK2B0.47756600
121PRKD10.47272846
122PTK60.47207179
123PTK20.46851653
124TNK20.46828688
125MAPK100.46770067
126HIPK20.46272580
127WNK10.46025336
128PRKG20.45917885
129RPS6KA10.44562149
130MAP3K60.44490522
131BRAF0.43623374
132* FYN0.43273225
133DYRK1A0.42824172
134SIK10.41350504
135ERBB20.41107446
136PDGFRB0.40660212
137PAK20.40460949
138ITK0.38363704
139CDK90.36101738
140GRK60.36096348
141PRKCB0.35871852
142MAPK80.34008969

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047402.80762085
2Nitrogen metabolism_Homo sapiens_hsa009102.49414648
3Nicotine addiction_Homo sapiens_hsa050332.44669101
4Circadian entrainment_Homo sapiens_hsa047132.37184393
5Amphetamine addiction_Homo sapiens_hsa050312.35393211
6GABAergic synapse_Homo sapiens_hsa047272.34172197
7Synaptic vesicle cycle_Homo sapiens_hsa047212.33324273
8Long-term potentiation_Homo sapiens_hsa047202.32325688
9Morphine addiction_Homo sapiens_hsa050322.26118305
10Glutamatergic synapse_Homo sapiens_hsa047242.16816778
11Cocaine addiction_Homo sapiens_hsa050302.15888720
12Dopaminergic synapse_Homo sapiens_hsa047282.11492098
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.07888063
14* Chronic myeloid leukemia_Homo sapiens_hsa052202.04713505
15Acute myeloid leukemia_Homo sapiens_hsa052212.04335622
16Notch signaling pathway_Homo sapiens_hsa043301.99996841
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.99944726
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.93367739
19Insulin secretion_Homo sapiens_hsa049111.93283995
20Cholinergic synapse_Homo sapiens_hsa047251.89942163
21Salivary secretion_Homo sapiens_hsa049701.88601417
22Renin secretion_Homo sapiens_hsa049241.75167236
23Gastric acid secretion_Homo sapiens_hsa049711.73930804
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62775669
25Thyroid cancer_Homo sapiens_hsa052161.56463251
26Oxytocin signaling pathway_Homo sapiens_hsa049211.51830805
27Pancreatic cancer_Homo sapiens_hsa052121.51302056
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.48041196
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.47201523
30Gap junction_Homo sapiens_hsa045401.45339592
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.42270644
32GnRH signaling pathway_Homo sapiens_hsa049121.41624450
33Glioma_Homo sapiens_hsa052141.38663483
34Type II diabetes mellitus_Homo sapiens_hsa049301.37032807
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35134423
36Long-term depression_Homo sapiens_hsa047301.33653429
37B cell receptor signaling pathway_Homo sapiens_hsa046621.30557194
38Calcium signaling pathway_Homo sapiens_hsa040201.29358577
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.29257433
40Taste transduction_Homo sapiens_hsa047421.28438247
41Estrogen signaling pathway_Homo sapiens_hsa049151.27085133
42Serotonergic synapse_Homo sapiens_hsa047261.22179279
43cAMP signaling pathway_Homo sapiens_hsa040241.22090363
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20281895
45MicroRNAs in cancer_Homo sapiens_hsa052061.15570968
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13840468
47Adherens junction_Homo sapiens_hsa045201.13148186
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11337264
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10505070
50Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10203170
51cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05631302
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05083123
53Melanogenesis_Homo sapiens_hsa049161.04975358
54Bile secretion_Homo sapiens_hsa049761.01912802
55ErbB signaling pathway_Homo sapiens_hsa040121.00493384
56Small cell lung cancer_Homo sapiens_hsa052221.00178944
57Prostate cancer_Homo sapiens_hsa052150.99887155
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.99729913
59ECM-receptor interaction_Homo sapiens_hsa045120.99129128
60Axon guidance_Homo sapiens_hsa043600.99057835
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96896034
62Dorso-ventral axis formation_Homo sapiens_hsa043200.94616676
63Thyroid hormone synthesis_Homo sapiens_hsa049180.94290199
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.92354371
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.91908053
66Non-small cell lung cancer_Homo sapiens_hsa052230.91036428
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.89533762
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86091245
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.85379975
70Other glycan degradation_Homo sapiens_hsa005110.85196710
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84774633
72mTOR signaling pathway_Homo sapiens_hsa041500.84695421
73Amoebiasis_Homo sapiens_hsa051460.82728854
74Lysine degradation_Homo sapiens_hsa003100.82564757
75Pancreatic secretion_Homo sapiens_hsa049720.82281474
76T cell receptor signaling pathway_Homo sapiens_hsa046600.81951166
77Arginine biosynthesis_Homo sapiens_hsa002200.81067130
78mRNA surveillance pathway_Homo sapiens_hsa030150.80067372
79Endometrial cancer_Homo sapiens_hsa052130.79196406
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79176245
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79046252
82VEGF signaling pathway_Homo sapiens_hsa043700.78695039
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.78651047
84Glucagon signaling pathway_Homo sapiens_hsa049220.75902367
85Rap1 signaling pathway_Homo sapiens_hsa040150.75060835
86Dilated cardiomyopathy_Homo sapiens_hsa054140.73009621
87HIF-1 signaling pathway_Homo sapiens_hsa040660.72016371
88Hippo signaling pathway_Homo sapiens_hsa043900.71986802
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71725762
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71683831
91Choline metabolism in cancer_Homo sapiens_hsa052310.71162746
92Oocyte meiosis_Homo sapiens_hsa041140.70195574
93* Pathways in cancer_Homo sapiens_hsa052000.69831433
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66644827
95MAPK signaling pathway_Homo sapiens_hsa040100.65662733
96Hepatitis C_Homo sapiens_hsa051600.64787683
97Phototransduction_Homo sapiens_hsa047440.64503174
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62523883
99Alcoholism_Homo sapiens_hsa050340.62066947
100Basal cell carcinoma_Homo sapiens_hsa052170.61900024
101Vitamin B6 metabolism_Homo sapiens_hsa007500.61769589
102Insulin signaling pathway_Homo sapiens_hsa049100.58666528
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56764605
104Melanoma_Homo sapiens_hsa052180.55469883
105Hepatitis B_Homo sapiens_hsa051610.55273614
106Renal cell carcinoma_Homo sapiens_hsa052110.55172270
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50654577
108Endocytosis_Homo sapiens_hsa041440.50451195
109Ras signaling pathway_Homo sapiens_hsa040140.50297934
110Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47968408
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.46567604
112Prion diseases_Homo sapiens_hsa050200.45844807
113Inositol phosphate metabolism_Homo sapiens_hsa005620.45234788
114Insulin resistance_Homo sapiens_hsa049310.44115148
115Butanoate metabolism_Homo sapiens_hsa006500.43052328
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42999936
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42403425
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.41629887
119Wnt signaling pathway_Homo sapiens_hsa043100.40879976
120Platelet activation_Homo sapiens_hsa046110.40610429
121Circadian rhythm_Homo sapiens_hsa047100.39621790
122Ovarian steroidogenesis_Homo sapiens_hsa049130.39065419
123Prolactin signaling pathway_Homo sapiens_hsa049170.38899619
124Bladder cancer_Homo sapiens_hsa052190.38231370
125Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36448826
126Tight junction_Homo sapiens_hsa045300.36055691
127AMPK signaling pathway_Homo sapiens_hsa041520.35973340
128Proteoglycans in cancer_Homo sapiens_hsa052050.35787279
129Type I diabetes mellitus_Homo sapiens_hsa049400.34555427
130Colorectal cancer_Homo sapiens_hsa052100.34079342
131Chemokine signaling pathway_Homo sapiens_hsa040620.33853389
132Focal adhesion_Homo sapiens_hsa045100.32099399
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31863092

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