BCRP7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adult feeding behavior (GO:0008343)8.51798522
2epithelial cilium movement (GO:0003351)6.91347125
3regulation of transmission of nerve impulse (GO:0051969)6.55007980
4positive regulation of catecholamine secretion (GO:0033605)6.39232153
5cilium movement (GO:0003341)5.88863068
6establishment of protein localization to mitochondrial membrane (GO:0090151)5.68735390
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.40385191
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.08611611
9maturation of SSU-rRNA (GO:0030490)4.97583835
10ATP synthesis coupled proton transport (GO:0015986)4.92140094
11energy coupled proton transport, down electrochemical gradient (GO:0015985)4.92140094
12negative regulation of appetite (GO:0032099)4.74326238
13negative regulation of response to food (GO:0032096)4.74326238
14GTP biosynthetic process (GO:0006183)4.47504268
15axonemal dynein complex assembly (GO:0070286)4.40819177
16respiratory electron transport chain (GO:0022904)4.34384689
17chaperone-mediated protein transport (GO:0072321)4.30319337
18electron transport chain (GO:0022900)4.28601639
19mitochondrial respiratory chain complex I assembly (GO:0032981)4.15638760
20NADH dehydrogenase complex assembly (GO:0010257)4.15638760
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.15638760
22UTP biosynthetic process (GO:0006228)4.12762784
23viral transcription (GO:0019083)4.11397531
24regulation of mitochondrial translation (GO:0070129)4.08223055
25positive regulation of neurological system process (GO:0031646)4.07800626
26protein complex biogenesis (GO:0070271)4.06414189
27translational termination (GO:0006415)4.04432275
28intracellular protein transmembrane import (GO:0044743)3.92101693
29left/right pattern formation (GO:0060972)3.88628650
30intraciliary transport (GO:0042073)3.87544221
31mitochondrial respiratory chain complex assembly (GO:0033108)3.85216857
32nucleoside diphosphate phosphorylation (GO:0006165)3.78447533
33protein polyglutamylation (GO:0018095)3.75453869
34UTP metabolic process (GO:0046051)3.70716871
35motile cilium assembly (GO:0044458)3.69081278
36cullin deneddylation (GO:0010388)3.67990957
37protein neddylation (GO:0045116)3.63708572
38SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.61696085
39ribosomal large subunit biogenesis (GO:0042273)3.58838298
40cotranslational protein targeting to membrane (GO:0006613)3.58150328
41translational elongation (GO:0006414)3.54437586
42ribosomal small subunit biogenesis (GO:0042274)3.54023039
43guanosine-containing compound biosynthetic process (GO:1901070)3.53679747
44protein targeting to ER (GO:0045047)3.52385579
45protein deneddylation (GO:0000338)3.51726624
46CTP biosynthetic process (GO:0006241)3.50807859
47CTP metabolic process (GO:0046036)3.50807859
48negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.47415345
49inner mitochondrial membrane organization (GO:0007007)3.46047396
50ribosomal small subunit assembly (GO:0000028)3.40449998
51establishment of protein localization to endoplasmic reticulum (GO:0072599)3.39613642
52purine nucleoside triphosphate biosynthetic process (GO:0009145)3.35009014
53purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.31611376
54pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.31088810
55behavioral response to nicotine (GO:0035095)3.30958427
56cilium morphogenesis (GO:0060271)3.28545637
57protein localization to endoplasmic reticulum (GO:0070972)3.26542900
58water-soluble vitamin biosynthetic process (GO:0042364)3.20120219
59tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.15625994
60RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.15625994
61regulation of feeding behavior (GO:0060259)3.15594782
62DNA double-strand break processing (GO:0000729)3.12397696
63cellular protein complex disassembly (GO:0043624)3.07182808
64ribonucleoside triphosphate biosynthetic process (GO:0009201)3.06609217
65spliceosomal snRNP assembly (GO:0000387)3.06080446
66ventricular system development (GO:0021591)3.05512276
67cilium or flagellum-dependent cell motility (GO:0001539)3.05163410
68pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.04436497
69pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.04406241
70epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.03059450
71pseudouridine synthesis (GO:0001522)2.98704890
72nucleoside triphosphate biosynthetic process (GO:0009142)2.95729651
73ATP biosynthetic process (GO:0006754)2.95013620
74establishment of protein localization to mitochondrion (GO:0072655)2.94893736
75regulation of dopamine secretion (GO:0014059)2.93419955
76pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.92882611
77nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.92145742
78regulation of catecholamine secretion (GO:0050433)2.92040088
79intracellular protein transmembrane transport (GO:0065002)2.91146852
80proteasome assembly (GO:0043248)2.90002120
81sperm motility (GO:0030317)2.86505465
82regulation of response to food (GO:0032095)2.85673927
83pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.85214079
84viral life cycle (GO:0019058)2.82705558
85translation (GO:0006412)2.81718804
86positive regulation of amine transport (GO:0051954)2.81188058
87cellular component biogenesis (GO:0044085)2.80169644
88axoneme assembly (GO:0035082)2.79236605
89detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.79225389
90detection of temperature stimulus involved in sensory perception (GO:0050961)2.79225389
91protein localization to cilium (GO:0061512)2.76946471
92negative regulation of bone resorption (GO:0045779)2.76574534
93regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.76396924
94maturation of 5.8S rRNA (GO:0000460)2.76149720
95protein localization to mitochondrion (GO:0070585)2.75925025
96relaxation of smooth muscle (GO:0044557)2.75553405
97determination of left/right symmetry (GO:0007368)2.73897547
98GPI anchor biosynthetic process (GO:0006506)2.72443056
99negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.71698965
100translational initiation (GO:0006413)2.71209280

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human3.91920443
2EST1_17652178_ChIP-ChIP_JURKAT_Human3.63008281
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.41508235
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.31088140
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.30236957
6FUS_26573619_Chip-Seq_HEK293_Human2.89906288
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.80288396
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.65662999
9EZH2_22144423_ChIP-Seq_EOC_Human2.63811159
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.63487123
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.38404291
12VDR_22108803_ChIP-Seq_LS180_Human2.35409511
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.31480569
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.24948504
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.23663262
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.22743624
17EWS_26573619_Chip-Seq_HEK293_Human2.22111626
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.16942579
19MYC_18940864_ChIP-ChIP_HL60_Human2.13085098
20VDR_23849224_ChIP-Seq_CD4+_Human2.06690477
21ELF1_17652178_ChIP-ChIP_JURKAT_Human1.92173308
22ELK1_19687146_ChIP-ChIP_HELA_Human1.89031662
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88919345
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.88526025
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.87291378
26XRN2_22483619_ChIP-Seq_HELA_Human1.78343041
27MYC_18555785_ChIP-Seq_MESCs_Mouse1.77771003
28GATA1_26923725_Chip-Seq_HPCs_Mouse1.77226754
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.75520801
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.74837876
31FOXP3_21729870_ChIP-Seq_TREG_Human1.68735558
32TTF2_22483619_ChIP-Seq_HELA_Human1.67606226
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.65204420
34BP1_19119308_ChIP-ChIP_Hs578T_Human1.64445682
35TAF15_26573619_Chip-Seq_HEK293_Human1.63993402
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61936049
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.60490679
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.56784840
39GBX2_23144817_ChIP-Seq_PC3_Human1.54586283
40P300_19829295_ChIP-Seq_ESCs_Human1.50589414
41ZNF274_21170338_ChIP-Seq_K562_Hela1.48737762
42GABP_19822575_ChIP-Seq_HepG2_Human1.48469289
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.47628380
44TP53_22573176_ChIP-Seq_HFKS_Human1.46975862
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.43004486
46RNF2_27304074_Chip-Seq_NSC_Mouse1.41261345
47MYC_18358816_ChIP-ChIP_MESCs_Mouse1.39031440
48CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.38887904
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.33093026
50ER_23166858_ChIP-Seq_MCF-7_Human1.28907885
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26280980
52TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26280980
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25698705
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.25145504
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24423235
56THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23499456
57E2F4_17652178_ChIP-ChIP_JURKAT_Human1.23046372
58FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22284022
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22162459
60CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.21656856
61HTT_18923047_ChIP-ChIP_STHdh_Human1.20978681
62DCP1A_22483619_ChIP-Seq_HELA_Human1.19650366
63SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.18095775
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.14664053
65AUTS2_25519132_ChIP-Seq_293T-REX_Human1.14189881
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12447451
67SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.11147682
68MYC_19030024_ChIP-ChIP_MESCs_Mouse1.10323315
69SOX2_19829295_ChIP-Seq_ESCs_Human1.09777067
70NANOG_19829295_ChIP-Seq_ESCs_Human1.09777067
71NCOR_22424771_ChIP-Seq_293T_Human1.08631864
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07562260
73IRF1_19129219_ChIP-ChIP_H3396_Human1.06856335
74MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06385734
75CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05746828
76ELK1_22589737_ChIP-Seq_MCF10A_Human1.05352921
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03458149
78REST_21632747_ChIP-Seq_MESCs_Mouse1.00718639
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00581055
80MYC_19079543_ChIP-ChIP_MESCs_Mouse0.99037500
81POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98445283
82CBP_20019798_ChIP-Seq_JUKART_Human0.97705443
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97705443
84CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97500677
85TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97344023
86CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.97138139
87RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97088323
88TCF4_22108803_ChIP-Seq_LS180_Human0.96253085
89AR_25329375_ChIP-Seq_VCAP_Human0.95855641
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92726960
91FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.92624292
92EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.92190291
93KDM5A_27292631_Chip-Seq_BREAST_Human0.91519038
94E2F1_17053090_ChIP-ChIP_MCF-7_Human0.89947503
95RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.89191265
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88371671
97TP63_19390658_ChIP-ChIP_HaCaT_Human0.87823216
98EZH2_27304074_Chip-Seq_ESCs_Mouse0.86919967
99REST_18959480_ChIP-ChIP_MESCs_Mouse0.86808211
100E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.86720694

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001529_abnormal_vocalization3.19553356
2MP0009697_abnormal_copulation3.05103415
3MP0000566_synostosis2.84660888
4MP0003136_yellow_coat_color2.42564586
5MP0003567_abnormal_fetal_cardiomyocyte2.34616180
6MP0003806_abnormal_nucleotide_metabolis2.32979139
7MP0009379_abnormal_foot_pigmentation2.30564430
8MP0001661_extended_life_span2.28927099
9MP0008058_abnormal_DNA_repair2.21137355
10MP0006072_abnormal_retinal_apoptosis2.20040270
11MP0003011_delayed_dark_adaptation2.10687489
12MP0001984_abnormal_olfaction2.07803378
13MP0008995_early_reproductive_senescence2.01801286
14MP0004133_heterotaxia1.97663588
15MP0001905_abnormal_dopamine_level1.89699130
16MP0003880_abnormal_central_pattern1.79078784
17MP0006276_abnormal_autonomic_nervous1.78097662
18MP0002837_dystrophic_cardiac_calcinosis1.77593568
19MP0005551_abnormal_eye_electrophysiolog1.76833597
20MP0004043_abnormal_pH_regulation1.74399868
21MP0005646_abnormal_pituitary_gland1.74320814
22MP0003786_premature_aging1.71140594
23MP0001968_abnormal_touch/_nociception1.68532407
24MP0005410_abnormal_fertilization1.65589959
25MP0005253_abnormal_eye_physiology1.64326878
26MP0002938_white_spotting1.59272018
27MP0002736_abnormal_nociception_after1.58583541
28MP0002160_abnormal_reproductive_system1.56612363
29MP0008877_abnormal_DNA_methylation1.56113478
30MP0002822_catalepsy1.54957593
31MP0000631_abnormal_neuroendocrine_gland1.54057366
32MP0001324_abnormal_eye_pigmentation1.47261909
33MP0000516_abnormal_urinary_system1.46412329
34MP0005367_renal/urinary_system_phenotyp1.46412329
35MP0005394_taste/olfaction_phenotype1.42801518
36MP0005499_abnormal_olfactory_system1.42801518
37MP0005075_abnormal_melanosome_morpholog1.39593269
38MP0003937_abnormal_limbs/digits/tail_de1.37229678
39MP0002163_abnormal_gland_morphology1.37202589
40MP0000569_abnormal_digit_pigmentation1.35994074
41MP0006035_abnormal_mitochondrial_morpho1.35138839
42MP0004145_abnormal_muscle_electrophysio1.34498300
43MP0001188_hyperpigmentation1.33872516
44MP0000372_irregular_coat_pigmentation1.33233019
45MP0002572_abnormal_emotion/affect_behav1.32828421
46MP0002909_abnormal_adrenal_gland1.32462103
47MP0010386_abnormal_urinary_bladder1.31674408
48MP0005171_absent_coat_pigmentation1.31288028
49MP0004142_abnormal_muscle_tone1.30424145
50MP0005408_hypopigmentation1.29937205
51MP0006292_abnormal_olfactory_placode1.29366044
52MP0008007_abnormal_cellular_replicative1.28826925
53MP0003137_abnormal_impulse_conducting1.26721778
54MP0009745_abnormal_behavioral_response1.25542396
55MP0008789_abnormal_olfactory_epithelium1.24201776
56MP0003186_abnormal_redox_activity1.23604292
57MP0002272_abnormal_nervous_system1.22075185
58MP0006036_abnormal_mitochondrial_physio1.21729767
59MP0005379_endocrine/exocrine_gland_phen1.20059479
60MP0002638_abnormal_pupillary_reflex1.19874413
61MP0004885_abnormal_endolymph1.18571502
62MP0005389_reproductive_system_phenotype1.18182839
63MP0001440_abnormal_grooming_behavior1.15274392
64MP0000778_abnormal_nervous_system1.14878472
65MP0003718_maternal_effect1.12923865
66MP0009046_muscle_twitch1.09968940
67MP0000049_abnormal_middle_ear1.07182244
68MP0002735_abnormal_chemical_nociception1.03775264
69MP0005084_abnormal_gallbladder_morpholo1.01754237
70MP0003635_abnormal_synaptic_transmissio1.01351058
71MP0004019_abnormal_vitamin_homeostasis0.99871955
72MP0002102_abnormal_ear_morphology0.97073118
73MP0003698_abnormal_male_reproductive0.97052983
74MP0008932_abnormal_embryonic_tissue0.94707521
75MP0000013_abnormal_adipose_tissue0.93755479
76MP0005187_abnormal_penis_morphology0.92464004
77MP0002234_abnormal_pharynx_morphology0.92383955
78MP0005195_abnormal_posterior_eye0.90061717
79MP0002210_abnormal_sex_determination0.89354617
80MP0005448_abnormal_energy_balance0.87636305
81MP0001764_abnormal_homeostasis0.87635132
82MP0008875_abnormal_xenobiotic_pharmacok0.87384037
83MP0001929_abnormal_gametogenesis0.87363581
84MP0002095_abnormal_skin_pigmentation0.87344521
85MP0002063_abnormal_learning/memory/cond0.85752671
86MP0004858_abnormal_nervous_system0.85477373
87MP0002557_abnormal_social/conspecific_i0.82942778
88MP0001485_abnormal_pinna_reflex0.81243534
89MP0010094_abnormal_chromosome_stability0.79910924
90MP0004085_abnormal_heartbeat0.77475585
91MP0000653_abnormal_sex_gland0.76705580
92MP0000343_altered_response_to0.76539905
93MP0009250_abnormal_appendicular_skeleto0.76255404
94MP0004957_abnormal_blastocyst_morpholog0.75987487
95MP0002734_abnormal_mechanical_nocicepti0.75773560
96MP0001486_abnormal_startle_reflex0.75274002
97MP0000026_abnormal_inner_ear0.74561159
98MP0001919_abnormal_reproductive_system0.74036222
99MP0001970_abnormal_pain_threshold0.74031921
100MP0008569_lethality_at_weaning0.72390257

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.83007048
2Abnormal mitochondria in muscle tissue (HP:0008316)4.51697562
3Abnormal respiratory motile cilium physiology (HP:0012261)3.99333245
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.93447708
5Progressive macrocephaly (HP:0004481)3.93156156
6Acute encephalopathy (HP:0006846)3.84210795
7True hermaphroditism (HP:0010459)3.81652642
8Abnormal ciliary motility (HP:0012262)3.80987568
9Mitochondrial inheritance (HP:0001427)3.80098287
10Pancreatic cysts (HP:0001737)3.77977620
11Lipid accumulation in hepatocytes (HP:0006561)3.57132298
12Molar tooth sign on MRI (HP:0002419)3.55241483
13Abnormality of midbrain morphology (HP:0002418)3.55241483
14Pancreatic fibrosis (HP:0100732)3.54578431
15Increased CSF lactate (HP:0002490)3.43076900
16Increased hepatocellular lipid droplets (HP:0006565)3.24399611
17Humeroradial synostosis (HP:0003041)3.18751970
18Synostosis involving the elbow (HP:0003938)3.18751970
19Abnormal respiratory epithelium morphology (HP:0012253)3.18140328
20Abnormal respiratory motile cilium morphology (HP:0005938)3.18140328
21Nephronophthisis (HP:0000090)3.14278453
22Rhinitis (HP:0012384)3.13785054
23Cerebral edema (HP:0002181)3.09166477
24Occipital encephalocele (HP:0002085)3.03893232
253-Methylglutaconic aciduria (HP:0003535)3.02676371
26Renal Fanconi syndrome (HP:0001994)3.01332834
27Type II lissencephaly (HP:0007260)2.99075969
28Hepatocellular necrosis (HP:0001404)2.89773236
29Congenital stationary night blindness (HP:0007642)2.88276652
30Hepatic necrosis (HP:0002605)2.82689267
31Short tibia (HP:0005736)2.78066627
32Fibular aplasia (HP:0002990)2.74910690
33Retinal dysplasia (HP:0007973)2.73270074
34Delayed CNS myelination (HP:0002188)2.71655123
35Cystic liver disease (HP:0006706)2.69223916
36Medial flaring of the eyebrow (HP:0010747)2.65323087
37Exercise intolerance (HP:0003546)2.64324907
38Absent/shortened dynein arms (HP:0200106)2.63948856
39Dynein arm defect of respiratory motile cilia (HP:0012255)2.63948856
40Increased serum lactate (HP:0002151)2.62219472
41Symphalangism affecting the phalanges of the hand (HP:0009773)2.58159468
42Short 1st metacarpal (HP:0010034)2.56971120
43Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.56971120
44Aplasia/Hypoplasia of the tibia (HP:0005772)2.49721045
45Abnormality of the 1st metacarpal (HP:0010009)2.48190513
46Short phalanx of the thumb (HP:0009660)2.47612501
47Limb dystonia (HP:0002451)2.45939389
48Abnormality of the phalanges of the 2nd finger (HP:0009541)2.45142297
49Chronic hepatic failure (HP:0100626)2.43226490
50Abnormality of the proximal phalanges of the hand (HP:0009834)2.41634446
51Optic disc pallor (HP:0000543)2.36265258
52Abnormality of the anterior horn cell (HP:0006802)2.34812573
53Degeneration of anterior horn cells (HP:0002398)2.34812573
54Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.33443356
55Sclerocornea (HP:0000647)2.29738732
56Abnormal biliary tract physiology (HP:0012439)2.29111123
57Bile duct proliferation (HP:0001408)2.29111123
58Congenital hepatic fibrosis (HP:0002612)2.28711150
59Abnormal number of erythroid precursors (HP:0012131)2.28461511
60Male pseudohermaphroditism (HP:0000037)2.27185770
61Exertional dyspnea (HP:0002875)2.26624708
62Anencephaly (HP:0002323)2.26122193
63Respiratory failure (HP:0002878)2.21517575
64Lactic acidosis (HP:0003128)2.18120165
65Abnormality of the renal medulla (HP:0100957)2.17338875
66Gait imbalance (HP:0002141)2.17054185
67Cerebellar dysplasia (HP:0007033)2.16812632
68Increased muscle lipid content (HP:0009058)2.16542728
69Increased intramyocellular lipid droplets (HP:0012240)2.15570783
70Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.15334288
71Leukodystrophy (HP:0002415)2.11806455
72Aplasia/Hypoplasia of the uvula (HP:0010293)2.11354363
73Abnormality of cells of the erythroid lineage (HP:0012130)2.05787327
74Aplasia/Hypoplasia of the tongue (HP:0010295)2.05723694
75Congenital primary aphakia (HP:0007707)2.05454420
76Abnormality of the middle phalanges of the toes (HP:0010183)2.05206091
77Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.02849151
78Decreased central vision (HP:0007663)2.02332264
79Furrowed tongue (HP:0000221)2.02279099
80Pendular nystagmus (HP:0012043)2.00948424
81Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.98158325
82Meckel diverticulum (HP:0002245)1.97970923
83Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.97665409
84Nephrogenic diabetes insipidus (HP:0009806)1.96618188
85Colon cancer (HP:0003003)1.94175049
86Abnormality of the ileum (HP:0001549)1.93203408
87Methylmalonic acidemia (HP:0002912)1.87659563
88Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.85277136
89Deformed tarsal bones (HP:0008119)1.83663647
90Aplasia/hypoplasia of the uterus (HP:0008684)1.83011104
91Abnormality of the phalanges of the 5th finger (HP:0004213)1.82973950
92Postaxial hand polydactyly (HP:0001162)1.82904439
93Mesomelia (HP:0003027)1.79108281
94Enlarged epiphyses (HP:0010580)1.78315195
95Abolished electroretinogram (ERG) (HP:0000550)1.78294153
96Postaxial foot polydactyly (HP:0001830)1.78214967
97Lissencephaly (HP:0001339)1.77631382
98Abnormality of renal resorption (HP:0011038)1.76704663
99Macrocytic anemia (HP:0001972)1.76663126
100Chronic bronchitis (HP:0004469)1.76583884

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK33.92878921
2BMPR1B3.72412906
3PNCK3.14365347
4MAP4K23.01674782
5BUB12.64568369
6TRIM282.60323411
7TAOK32.45640952
8CCNB12.40899655
9PINK12.39419291
10TLK12.29899168
11WEE12.29573633
12NME22.23912129
13TIE12.18639474
14MUSK2.00371322
15BCKDK1.95623920
16WNK41.91370621
17PLK41.91057425
18GRK11.86517408
19SRPK11.81882179
20MAPKAPK31.81698043
21CDK81.78897293
22MAPKAPK51.61214158
23MARK11.60756388
24MAP2K71.58780753
25MAP3K41.58015640
26TNIK1.57014303
27DYRK21.47333234
28RPS6KA51.47260442
29ERBB31.43411404
30TESK11.38363722
31ZAK1.33745429
32DYRK31.33035140
33TGFBR11.32144266
34EPHB11.29770736
35CASK1.25009842
36NEK11.23139015
37CSNK1G21.22295812
38VRK11.20957912
39PHKG21.18827771
40PHKG11.18827771
41MKNK11.14767138
42ADRBK21.10897391
43MAPK131.06872076
44MARK31.05454145
45TSSK61.03853032
46NUAK11.00712203
47MAPK151.00694554
48PRKCG0.90432543
49VRK20.87461360
50AKT30.87461194
51STK160.84430469
52BCR0.78311048
53RPS6KA40.76082761
54PAK30.74060326
55CSNK1G30.71246164
56AURKA0.69554103
57DAPK10.62759907
58PLK10.62091457
59STK40.60596813
60INSRR0.58978299
61PTK2B0.58942039
62NEK20.57002266
63PLK20.54920997
64DYRK1A0.49847052
65TTK0.48558307
66TEC0.47640836
67LATS10.47622926
68PASK0.47517861
69PDK20.46615702
70PRKACA0.44959632
71AURKB0.44823736
72DAPK20.43522208
73PBK0.43174110
74IRAK20.43001002
75PLK30.42789712
76CSNK1G10.42031558
77CSNK2A10.41716429
78OBSCN0.41122620
79MAP2K40.39524337
80ALK0.39333272
81MKNK20.38986658
82CSNK2A20.38696251
83CSNK1A1L0.37533737
84CAMK2A0.37284651
85STK380.37173991
86STK390.36553627
87CDK30.36319482
88PAK60.36110192
89PRKCE0.35874347
90GRK50.34477867
91TNK20.33589162
92ATR0.31854158
93PRKCI0.31780364
94TRPM70.26858776
95CDK140.26200590
96CSNK1D0.26100219
97FRK0.24739714
98PRKACB0.24156208
99PIM20.24124686
100BRAF0.23416897

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.50688596
2Ribosome_Homo sapiens_hsa030104.24444710
3Parkinsons disease_Homo sapiens_hsa050124.09067320
4RNA polymerase_Homo sapiens_hsa030202.99081365
5Huntingtons disease_Homo sapiens_hsa050162.94692293
6Alzheimers disease_Homo sapiens_hsa050102.66138355
7Sulfur relay system_Homo sapiens_hsa041222.37808900
8Protein export_Homo sapiens_hsa030602.31679485
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.21559330
10Proteasome_Homo sapiens_hsa030502.15930916
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.01963156
12Pyrimidine metabolism_Homo sapiens_hsa002402.01332503
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.93898211
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.93167139
15Nitrogen metabolism_Homo sapiens_hsa009101.92570043
16Homologous recombination_Homo sapiens_hsa034401.89800311
17Cardiac muscle contraction_Homo sapiens_hsa042601.86746926
18Phototransduction_Homo sapiens_hsa047441.78395498
19Nicotine addiction_Homo sapiens_hsa050331.76708712
20Fanconi anemia pathway_Homo sapiens_hsa034601.60196313
21Selenocompound metabolism_Homo sapiens_hsa004501.56192119
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.55941982
23Nucleotide excision repair_Homo sapiens_hsa034201.55307876
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.55078774
25One carbon pool by folate_Homo sapiens_hsa006701.51514304
26DNA replication_Homo sapiens_hsa030301.51208995
27Purine metabolism_Homo sapiens_hsa002301.41786381
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.36496006
29RNA degradation_Homo sapiens_hsa030181.33311917
30Basal transcription factors_Homo sapiens_hsa030221.30837767
31Spliceosome_Homo sapiens_hsa030401.21667369
32Peroxisome_Homo sapiens_hsa041461.16120681
33Mismatch repair_Homo sapiens_hsa034301.09609349
34RNA transport_Homo sapiens_hsa030131.09295906
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.08440913
36Pyruvate metabolism_Homo sapiens_hsa006201.07221047
37Collecting duct acid secretion_Homo sapiens_hsa049661.02388803
38Base excision repair_Homo sapiens_hsa034100.94470395
39Folate biosynthesis_Homo sapiens_hsa007900.94255820
40Metabolic pathways_Homo sapiens_hsa011000.94180858
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93557184
42Propanoate metabolism_Homo sapiens_hsa006400.93074572
43Glutathione metabolism_Homo sapiens_hsa004800.92296795
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91829475
45Chemical carcinogenesis_Homo sapiens_hsa052040.87902034
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85561276
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.83634274
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80881869
49Taste transduction_Homo sapiens_hsa047420.80360176
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79600194
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78727511
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78306570
53Fatty acid elongation_Homo sapiens_hsa000620.71447796
54Arginine and proline metabolism_Homo sapiens_hsa003300.71100063
55Gap junction_Homo sapiens_hsa045400.71069468
56Olfactory transduction_Homo sapiens_hsa047400.70211376
57Linoleic acid metabolism_Homo sapiens_hsa005910.69892693
58N-Glycan biosynthesis_Homo sapiens_hsa005100.65177872
59Butanoate metabolism_Homo sapiens_hsa006500.64005707
60Tyrosine metabolism_Homo sapiens_hsa003500.63713056
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62721923
62Non-homologous end-joining_Homo sapiens_hsa034500.61578909
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61170246
64Tryptophan metabolism_Homo sapiens_hsa003800.58128408
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57291723
66Alcoholism_Homo sapiens_hsa050340.56383070
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56169549
68beta-Alanine metabolism_Homo sapiens_hsa004100.56015855
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53338405
70Regulation of autophagy_Homo sapiens_hsa041400.51433087
71Circadian entrainment_Homo sapiens_hsa047130.50813888
72GABAergic synapse_Homo sapiens_hsa047270.49771206
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48830259
74Arginine biosynthesis_Homo sapiens_hsa002200.47601314
75Galactose metabolism_Homo sapiens_hsa000520.46436024
76Morphine addiction_Homo sapiens_hsa050320.45834424
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45750333
78Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45400513
79Fatty acid degradation_Homo sapiens_hsa000710.44157182
80Hedgehog signaling pathway_Homo sapiens_hsa043400.43918076
81Glycerolipid metabolism_Homo sapiens_hsa005610.43592478
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.41678531
83Synaptic vesicle cycle_Homo sapiens_hsa047210.40639910
84Systemic lupus erythematosus_Homo sapiens_hsa053220.40137673
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40129703
86Retinol metabolism_Homo sapiens_hsa008300.39185660
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.39032529
88Fat digestion and absorption_Homo sapiens_hsa049750.38337967
89Serotonergic synapse_Homo sapiens_hsa047260.35877311
90Cocaine addiction_Homo sapiens_hsa050300.35728508
91Fructose and mannose metabolism_Homo sapiens_hsa000510.35491645
92Oocyte meiosis_Homo sapiens_hsa041140.35263293
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.32956136
94Glutamatergic synapse_Homo sapiens_hsa047240.31505233
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30691161
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.30321046
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29667414
98TGF-beta signaling pathway_Homo sapiens_hsa043500.28703571
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28665079
100Starch and sucrose metabolism_Homo sapiens_hsa005000.27775432

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