BCS1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a homolog of the S. cerevisiae bcs1 protein which is involved in the assembly of complex III of the mitochondrial respiratory chain. The encoded protein does not contain a mitochondrial targeting sequence but experimental studies confirm that it is imported into mitochondria. Mutations in this gene are associated with mitochondrial complex III deficiency and the GRACILE syndrome. Several alternatively spliced transcripts encoding two different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.23232419
2ATP synthesis coupled proton transport (GO:0015986)6.48120228
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.48120228
4ribosomal small subunit assembly (GO:0000028)6.13578281
5viral transcription (GO:0019083)6.02694143
6translational termination (GO:0006415)5.88932617
7ribosomal small subunit biogenesis (GO:0042274)5.70482877
8maturation of SSU-rRNA (GO:0030490)5.58271384
9respiratory electron transport chain (GO:0022904)5.30940498
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.22486733
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.22219060
12electron transport chain (GO:0022900)5.21628110
13cotranslational protein targeting to membrane (GO:0006613)5.19799829
14translational elongation (GO:0006414)5.19494988
15protein targeting to ER (GO:0045047)5.12985011
16oxidative phosphorylation (GO:0006119)5.00346164
17protein localization to endoplasmic reticulum (GO:0070972)4.94512416
18establishment of protein localization to endoplasmic reticulum (GO:0072599)4.89841323
19L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.72073778
20cellular protein complex disassembly (GO:0043624)4.69002620
21NADH metabolic process (GO:0006734)4.67100025
22translational initiation (GO:0006413)4.49706518
23viral life cycle (GO:0019058)4.46343734
24nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.40606729
25ribosomal large subunit biogenesis (GO:0042273)4.25671916
26* mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.24642321
27* mitochondrial respiratory chain complex I assembly (GO:0032981)4.24642321
28* NADH dehydrogenase complex assembly (GO:0010257)4.24642321
29* protein complex biogenesis (GO:0070271)4.20883949
30chaperone-mediated protein transport (GO:0072321)4.13572398
31L-methionine salvage (GO:0071267)4.06132906
32L-methionine biosynthetic process (GO:0071265)4.06132906
33amino acid salvage (GO:0043102)4.06132906
34proteasome assembly (GO:0043248)4.04236422
35translation (GO:0006412)3.98804557
36protein complex disassembly (GO:0043241)3.97905394
37* mitochondrial respiratory chain complex assembly (GO:0033108)3.93887781
38telomere maintenance via semi-conservative replication (GO:0032201)3.91241187
39cullin deneddylation (GO:0010388)3.88095856
40tricarboxylic acid cycle (GO:0006099)3.86483206
41protein deneddylation (GO:0000338)3.85941063
42DNA strand elongation (GO:0022616)3.83599366
43ubiquinone biosynthetic process (GO:0006744)3.82357600
44quinone biosynthetic process (GO:1901663)3.82357600
45regulation of mitochondrial translation (GO:0070129)3.82228587
46macromolecular complex disassembly (GO:0032984)3.80699845
47establishment of protein localization to mitochondrial membrane (GO:0090151)3.79845140
48ribonucleoprotein complex biogenesis (GO:0022613)3.70449596
49maturation of 5.8S rRNA (GO:0000460)3.69991206
50pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.69519975
51inner mitochondrial membrane organization (GO:0007007)3.67962077
52* cellular component biogenesis (GO:0044085)3.63746574
53regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.57286190
54peptidyl-histidine modification (GO:0018202)3.53731221
55pseudouridine synthesis (GO:0001522)3.53139568
56* respiratory chain complex IV assembly (GO:0008535)3.52056391
57DNA deamination (GO:0045006)3.52021136
58GTP biosynthetic process (GO:0006183)3.51494032
59ribosome assembly (GO:0042255)3.50975567
60aerobic respiration (GO:0009060)3.50283484
61regulation of acyl-CoA biosynthetic process (GO:0050812)3.49002395
62purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.44708217
63purine nucleoside triphosphate biosynthetic process (GO:0009145)3.44371360
64protein targeting to membrane (GO:0006612)3.43849112
65transcription from mitochondrial promoter (GO:0006390)3.43542165
66oxaloacetate metabolic process (GO:0006107)3.42965133
67ATP biosynthetic process (GO:0006754)3.42769413
68anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.41904764
69protein targeting to mitochondrion (GO:0006626)3.39611034
70mitochondrial RNA metabolic process (GO:0000959)3.37714782
71nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.36727805
72metallo-sulfur cluster assembly (GO:0031163)3.36201020
73iron-sulfur cluster assembly (GO:0016226)3.36201020
74guanosine-containing compound biosynthetic process (GO:1901070)3.35258594
75exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.34115719
76ubiquinone metabolic process (GO:0006743)3.33773837
77regulation of cofactor metabolic process (GO:0051193)3.32564008
78regulation of coenzyme metabolic process (GO:0051196)3.32564008
79pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.30460920
80transcription-coupled nucleotide-excision repair (GO:0006283)3.29283020
81establishment of protein localization to mitochondrion (GO:0072655)3.29166078
82regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.28919503
83spliceosomal snRNP assembly (GO:0000387)3.28747861
84DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.28013486
85succinate metabolic process (GO:0006105)3.27795792
86DNA damage response, detection of DNA damage (GO:0042769)3.27464769
87ribonucleoside triphosphate biosynthetic process (GO:0009201)3.25609753
88regulation of oxidative phosphorylation (GO:0002082)3.24902903
89UTP biosynthetic process (GO:0006228)3.24663350
90signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.24521247
91signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.24521247
92signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.24521247
93negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.23274918
94pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.21756576
95signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.21554874
96intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.21554874
97positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.20271431
98transcription elongation from RNA polymerase III promoter (GO:0006385)3.20206254
99termination of RNA polymerase III transcription (GO:0006386)3.20206254
100telomere maintenance via recombination (GO:0000722)3.19121055
101UTP metabolic process (GO:0046051)3.18967649
102nucleobase biosynthetic process (GO:0046112)3.18646486
103rRNA modification (GO:0000154)3.17648194
104base-excision repair, AP site formation (GO:0006285)3.17410850
105signal transduction involved in DNA integrity checkpoint (GO:0072401)3.17067629
106signal transduction involved in DNA damage checkpoint (GO:0072422)3.17067629
107establishment of integrated proviral latency (GO:0075713)3.16003258
108protein maturation by protein folding (GO:0022417)3.15380669
109tRNA processing (GO:0008033)3.15222009
110protein localization to mitochondrion (GO:0070585)3.13813121
111nuclear-transcribed mRNA catabolic process (GO:0000956)3.13501415
112DNA catabolic process, exonucleolytic (GO:0000738)3.12150706
113pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.11549821
114signal transduction involved in cell cycle checkpoint (GO:0072395)3.10935086
115mitochondrial transport (GO:0006839)3.09551077
116tRNA metabolic process (GO:0006399)3.09462793
117regulation of cellular amino acid metabolic process (GO:0006521)3.07983880
118ribosome biogenesis (GO:0042254)3.07511515
119nucleotide-excision repair, DNA gap filling (GO:0006297)3.06871878
120deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.06056422
121rRNA methylation (GO:0031167)3.05887214
122pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.05665086
123purine nucleobase biosynthetic process (GO:0009113)3.05480498
124mitotic recombination (GO:0006312)3.05431803
125histone H2A acetylation (GO:0043968)3.04883649
126tRNA modification (GO:0006400)3.04816098
127dopamine transport (GO:0015872)3.04762016
128rRNA processing (GO:0006364)3.04232986
129amino acid activation (GO:0043038)3.04043129
130tRNA aminoacylation (GO:0043039)3.04043129
131purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.02110891
132purine nucleoside monophosphate biosynthetic process (GO:0009127)3.02110891
133CTP biosynthetic process (GO:0006241)3.01942974
134CTP metabolic process (GO:0046036)3.01942974
135negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.98114945
136negative regulation of ligase activity (GO:0051352)2.98114945
137formation of translation preinitiation complex (GO:0001731)2.95457492
138mRNA catabolic process (GO:0006402)2.92671849
139rRNA metabolic process (GO:0016072)2.91786576
140pteridine-containing compound biosynthetic process (GO:0042559)2.90752691
141positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.89502606
142cellular respiration (GO:0045333)2.89072210
143* cytochrome complex assembly (GO:0017004)2.89016553
144DNA strand elongation involved in DNA replication (GO:0006271)2.87771197
145methionine metabolic process (GO:0006555)2.86070554

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_18555785_ChIP-Seq_MESCs_Mouse4.76028575
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.49643143
3* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.43902517
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.04849056
5EST1_17652178_ChIP-ChIP_JURKAT_Human4.04482540
6GABP_17652178_ChIP-ChIP_JURKAT_Human4.04431043
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.94470497
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.80980340
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.53126181
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.41082991
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.40977445
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.35165562
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.34163191
14* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.00308727
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.82835002
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.75398922
17* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.72572341
18XRN2_22483619_ChIP-Seq_HELA_Human2.68578572
19E2F7_22180533_ChIP-Seq_HELA_Human2.68112327
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.66008387
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.49994657
22DCP1A_22483619_ChIP-Seq_HELA_Human2.48048266
23E2F1_18555785_ChIP-Seq_MESCs_Mouse2.44636152
24* VDR_23849224_ChIP-Seq_CD4+_Human2.43630040
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.37777662
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.31512141
27FOXP3_21729870_ChIP-Seq_TREG_Human2.27368606
28YY1_21170310_ChIP-Seq_MESCs_Mouse2.26592811
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.24487255
30GABP_19822575_ChIP-Seq_HepG2_Human2.22557966
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.18638021
32TTF2_22483619_ChIP-Seq_HELA_Human2.15921217
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.05279771
34ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.00878377
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.96071076
36ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.91582931
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91404451
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.88838021
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.86004451
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.85738387
41E2F4_17652178_ChIP-ChIP_JURKAT_Human1.79960310
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76756157
43* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.75499014
44ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.71342428
45CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.68575184
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.66985413
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66277590
48CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.65228228
49* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.64947145
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.62690623
51ERG_20887958_ChIP-Seq_HPC-7_Mouse1.61725918
52CIITA_25753668_ChIP-Seq_RAJI_Human1.60684577
53* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60358086
54FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.58985666
55MYC_18940864_ChIP-ChIP_HL60_Human1.50460864
56ELK1_19687146_ChIP-ChIP_HELA_Human1.50062752
57CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.45311650
58BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.45296554
59EZH2_22144423_ChIP-Seq_EOC_Human1.41679584
60DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41421083
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37337342
62CTCF_18555785_ChIP-Seq_MESCs_Mouse1.36620321
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.36608164
64MYCN_18555785_ChIP-Seq_MESCs_Mouse1.35709935
65* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.29843299
66HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25457590
67MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24189488
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22263213
69ELK1_22589737_ChIP-Seq_MCF10A_Human1.19183200
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17308729
71* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16562525
72GATA1_22025678_ChIP-Seq_K562_Human1.16037334
73KDM5A_27292631_Chip-Seq_BREAST_Human1.11786294
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10312073
75CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09614099
76ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09472701
77TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06388700
78FOXM1_23109430_ChIP-Seq_U2OS_Human1.05975920
79IRF1_19129219_ChIP-ChIP_H3396_Human1.05511206
80CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05168390
81AR_21909140_ChIP-Seq_LNCAP_Human1.05051316
82STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04654748
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.02896109
84SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01494647
85POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98205783
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96378498
87TFEB_21752829_ChIP-Seq_HELA_Human0.93396586
88CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93009180
89* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91757693
90TET1_21451524_ChIP-Seq_MESCs_Mouse0.91067310
91ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90463356
92ELF1_20517297_ChIP-Seq_JURKAT_Human0.88037127
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87757475
94* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.86052245
95* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85648367
96SRY_22984422_ChIP-ChIP_TESTIS_Rat0.85338760
97FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.84975950
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84183975
99E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84124448
100E2F1_21310950_ChIP-Seq_MCF-7_Human0.83912614
101FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83037625
102* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.81428408
103ZNF263_19887448_ChIP-Seq_K562_Human0.81075583
104YY1_22570637_ChIP-Seq_MALME-3M_Human0.80862333
105TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.79003624
106LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.78475692
107RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.78233964
108CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.77188343
109EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.76610293
110* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.72554834
111TBX5_21415370_ChIP-Seq_HL-1_Mouse0.72547243
112SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.72239619
113CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.71192736
114EGR1_23403033_ChIP-Seq_LIVER_Mouse0.69573794
115FOXP1_21924763_ChIP-Seq_HESCs_Human0.68646601

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.45132362
2MP0002837_dystrophic_cardiac_calcinosis4.04537532
3MP0006036_abnormal_mitochondrial_physio3.51158070
4MP0001529_abnormal_vocalization3.45495826
5MP0003806_abnormal_nucleotide_metabolis3.20884617
6MP0003646_muscle_fatigue2.78347996
7MP0006292_abnormal_olfactory_placode2.60874483
8MP0008007_abnormal_cellular_replicative2.57981716
9MP0008789_abnormal_olfactory_epithelium2.45494373
10MP0006035_abnormal_mitochondrial_morpho2.38209266
11MP0004957_abnormal_blastocyst_morpholog2.26952246
12MP0004215_abnormal_myocardial_fiber2.24562789
13MP0000751_myopathy2.18499151
14MP0000749_muscle_degeneration2.17954406
15MP0002139_abnormal_hepatobiliary_system2.13130050
16MP0004147_increased_porphyrin_level2.07702405
17MP0005085_abnormal_gallbladder_physiolo1.90745086
18MP0005394_taste/olfaction_phenotype1.88614878
19MP0005499_abnormal_olfactory_system1.88614878
20MP0005330_cardiomyopathy1.83667775
21MP0002638_abnormal_pupillary_reflex1.80587507
22MP0002736_abnormal_nociception_after1.78718787
23MP0003186_abnormal_redox_activity1.76321285
24MP0001905_abnormal_dopamine_level1.74037241
25MP0000747_muscle_weakness1.71724593
26MP0005360_urolithiasis1.68502070
27MP0005365_abnormal_bile_salt1.65114297
28MP0010094_abnormal_chromosome_stability1.64291589
29MP0001764_abnormal_homeostasis1.64255611
30MP0000372_irregular_coat_pigmentation1.63120290
31MP0004036_abnormal_muscle_relaxation1.62789057
32MP0003880_abnormal_central_pattern1.61759875
33MP0001986_abnormal_taste_sensitivity1.58123899
34MP0004084_abnormal_cardiac_muscle1.57319875
35MP0003693_abnormal_embryo_hatching1.56907891
36MP0004142_abnormal_muscle_tone1.53023508
37MP0002822_catalepsy1.52751365
38MP0003123_paternal_imprinting1.50607130
39MP0005084_abnormal_gallbladder_morpholo1.50204205
40MP0002163_abnormal_gland_morphology1.47453309
41MP0003786_premature_aging1.47347559
42MP0001968_abnormal_touch/_nociception1.46828687
43MP0002396_abnormal_hematopoietic_system1.46171045
44MP0001188_hyperpigmentation1.46107483
45MP0005266_abnormal_metabolism1.44742853
46MP0003656_abnormal_erythrocyte_physiolo1.43149793
47MP0004145_abnormal_muscle_electrophysio1.41373044
48MP0009697_abnormal_copulation1.38355568
49MP0003567_abnormal_fetal_cardiomyocyte1.37042048
50MP0006276_abnormal_autonomic_nervous1.33860328
51MP0005332_abnormal_amino_acid1.33580421
52MP0008058_abnormal_DNA_repair1.32936088
53MP0002102_abnormal_ear_morphology1.30427796
54MP0002132_abnormal_respiratory_system1.28610663
55MP0004484_altered_response_of1.27906782
56MP0000313_abnormal_cell_death1.27673524
57MP0008875_abnormal_xenobiotic_pharmacok1.27563782
58MP0005174_abnormal_tail_pigmentation1.26204163
59MP0005645_abnormal_hypothalamus_physiol1.25845638
60MP0001730_embryonic_growth_arrest1.24468766
61MP0002160_abnormal_reproductive_system1.24329385
62MP0005584_abnormal_enzyme/coenzyme_acti1.23668115
63MP0003011_delayed_dark_adaptation1.23519951
64MP0003137_abnormal_impulse_conducting1.22465317
65MP0009745_abnormal_behavioral_response1.22309148
66MP0008932_abnormal_embryonic_tissue1.21041398
67MP0008872_abnormal_physiological_respon1.20699125
68MP0005636_abnormal_mineral_homeostasis1.20389051
69MP0005397_hematopoietic_system_phenotyp1.19402215
70MP0001545_abnormal_hematopoietic_system1.19402215
71MP0003221_abnormal_cardiomyocyte_apopto1.17610713
72MP0003077_abnormal_cell_cycle1.17610507
73MP0005220_abnormal_exocrine_pancreas1.16813433
74MP0003718_maternal_effect1.16500170
75MP0005075_abnormal_melanosome_morpholog1.14932325
76MP0003195_calcinosis1.13795626
77MP0002210_abnormal_sex_determination1.10749170
78MP0002106_abnormal_muscle_physiology1.09313342
79MP0003111_abnormal_nucleus_morphology1.09032278
80MP0002080_prenatal_lethality1.08362358
81MP0002095_abnormal_skin_pigmentation1.07358037
82MP0002234_abnormal_pharynx_morphology1.07169405
83MP0000350_abnormal_cell_proliferation1.06715489
84MP0005376_homeostasis/metabolism_phenot1.04525220
85MP0001697_abnormal_embryo_size1.04200974
86MP0004130_abnormal_muscle_cell1.04101822
87MP0001929_abnormal_gametogenesis1.02065395
88MP0002272_abnormal_nervous_system1.01989418
89MP0003315_abnormal_perineum_morphology0.97659110
90MP0000358_abnormal_cell_content/0.97024615
91MP0001145_abnormal_male_reproductive0.95766797
92MP0005319_abnormal_enzyme/_coenzyme0.95747447
93MP0005620_abnormal_muscle_contractility0.95712427
94MP0002269_muscular_atrophy0.95347333
95MP0001293_anophthalmia0.94783848
96MP0000750_abnormal_muscle_regeneration0.94623826
97MP0006072_abnormal_retinal_apoptosis0.94408737
98MP0002938_white_spotting0.94287968
99MP0002019_abnormal_tumor_incidence0.94186300
100MP0003635_abnormal_synaptic_transmissio0.94081828
101MP0005535_abnormal_body_temperature0.92894225
102MP0001501_abnormal_sleep_pattern0.91617287
103MP0002972_abnormal_cardiac_muscle0.91374861
104MP0000653_abnormal_sex_gland0.88861194
105MP0001544_abnormal_cardiovascular_syste0.87944076
106MP0005385_cardiovascular_system_phenoty0.87944076
107MP0003122_maternal_imprinting0.87808709
108MP0005369_muscle_phenotype0.87323597
109MP0005670_abnormal_white_adipose0.86726899
110MP0001853_heart_inflammation0.85524501
111MP0001672_abnormal_embryogenesis/_devel0.85244395
112MP0005380_embryogenesis_phenotype0.85244395
113MP0010329_abnormal_lipoprotein_level0.84794789
114MP0001440_abnormal_grooming_behavior0.84703035
115MP0001661_extended_life_span0.81623618
116MP0001727_abnormal_embryo_implantation0.80938102
117MP0002064_seizures0.79374194
118MP0004233_abnormal_muscle_weight0.78183230
119MP0010030_abnormal_orbit_morphology0.75865775
120MP0002572_abnormal_emotion/affect_behav0.75704372
121MP0005423_abnormal_somatic_nervous0.75394599
122MP0000759_abnormal_skeletal_muscle0.74032925
123MP0004085_abnormal_heartbeat0.73073292
124MP0008873_increased_physiological_sensi0.71624914
125MP0000049_abnormal_middle_ear0.70294513
126MP0005379_endocrine/exocrine_gland_phen0.69658003
127MP0002085_abnormal_embryonic_tissue0.69143529
128MP0004087_abnormal_muscle_fiber0.69006324
129MP0002078_abnormal_glucose_homeostasis0.68272652
130MP0003698_abnormal_male_reproductive0.68140957
131MP0008057_abnormal_DNA_replication0.67996308
132MP0008995_early_reproductive_senescence0.67617167
133MP0003984_embryonic_growth_retardation0.66303289
134MP0000230_abnormal_systemic_arterial0.66075438
135MP0002735_abnormal_chemical_nociception0.65916395
136MP0002063_abnormal_learning/memory/cond0.65890118
137MP0001119_abnormal_female_reproductive0.65696866
138MP0002332_abnormal_exercise_endurance0.65282626
139MP0005551_abnormal_eye_electrophysiolog0.64855117
140MP0002088_abnormal_embryonic_growth/wei0.64482952
141MP0008877_abnormal_DNA_methylation0.63701486
142MP0002067_abnormal_sensory_capabilities0.63404062
143MP0004924_abnormal_behavior0.63144048
144MP0005386_behavior/neurological_phenoty0.63144048
145MP0003868_abnormal_feces_composition0.62764727
146MP0005389_reproductive_system_phenotype0.62287912
147MP0001984_abnormal_olfaction0.62053348
148MP0003950_abnormal_plasma_membrane0.61143814
149MP0000015_abnormal_ear_pigmentation0.60796556
150MP0003385_abnormal_body_wall0.60774418
151MP0002249_abnormal_larynx_morphology0.60251785
152MP0005501_abnormal_skin_physiology0.60164028
153MP0002084_abnormal_developmental_patter0.59401310
154MP0000490_abnormal_crypts_of0.58959227
155MP0005452_abnormal_adipose_tissue0.58816056
156MP0003121_genomic_imprinting0.57546341
157MP0000678_abnormal_parathyroid_gland0.57221461
158MP0005384_cellular_phenotype0.56895807

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.59784552
2Abnormal mitochondria in muscle tissue (HP:0008316)5.47004629
3* Mitochondrial inheritance (HP:0001427)5.28926859
4* Hepatocellular necrosis (HP:0001404)5.27829305
5Acute encephalopathy (HP:0006846)5.10560826
6* Increased CSF lactate (HP:0002490)5.03262115
7* Hepatic necrosis (HP:0002605)4.93134533
8Decreased activity of mitochondrial respiratory chain (HP:0008972)4.56751618
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.56751618
10Abnormality of cells of the erythroid lineage (HP:0012130)4.56475001
11Abnormal number of erythroid precursors (HP:0012131)4.51589798
12Progressive macrocephaly (HP:0004481)4.48589078
13Increased hepatocellular lipid droplets (HP:0006565)4.24382721
14Lipid accumulation in hepatocytes (HP:0006561)4.23735456
15* Increased serum pyruvate (HP:0003542)4.17053562
16* Abnormality of glycolysis (HP:0004366)4.17053562
17* Lactic acidosis (HP:0003128)4.01478233
18* Increased serum lactate (HP:0002151)4.00076455
19Cerebral edema (HP:0002181)3.93428346
20Increased intramyocellular lipid droplets (HP:0012240)3.93413727
21Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.88783015
22Increased muscle lipid content (HP:0009058)3.76140518
23Abnormality of alanine metabolism (HP:0010916)3.54527619
24Hyperalaninemia (HP:0003348)3.54527619
25Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.54527619
26* Exercise intolerance (HP:0003546)3.49577452
27* Respiratory failure (HP:0002878)3.41943700
28Renal Fanconi syndrome (HP:0001994)3.40486296
29Reticulocytopenia (HP:0001896)3.36612755
30Macrocytic anemia (HP:0001972)3.34701752
31Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.20663746
32Aplastic anemia (HP:0001915)3.19605932
333-Methylglutaconic aciduria (HP:0003535)3.15095375
34* Ragged-red muscle fibers (HP:0003200)3.11170017
35Respiratory difficulties (HP:0002880)3.01598176
36Dicarboxylic aciduria (HP:0003215)2.97425060
37Abnormality of dicarboxylic acid metabolism (HP:0010995)2.97425060
38Lethargy (HP:0001254)2.93255219
39Chromosomal breakage induced by crosslinking agents (HP:0003221)2.90183084
40* CNS demyelination (HP:0007305)2.90034700
41Chromsome breakage (HP:0040012)2.85504708
42Abnormality of the heme biosynthetic pathway (HP:0010472)2.73952516
43Optic disc pallor (HP:0000543)2.68747305
44* Microvesicular hepatic steatosis (HP:0001414)2.67940188
45Hypoglycemic coma (HP:0001325)2.67001275
46Methylmalonic aciduria (HP:0012120)2.61766066
47Testicular atrophy (HP:0000029)2.59607676
48* Emotional lability (HP:0000712)2.59180396
49Pallor (HP:0000980)2.57092933
50Hyperglycinemia (HP:0002154)2.56365277
51Progressive microcephaly (HP:0000253)2.54968203
52Abnormality of aromatic amino acid family metabolism (HP:0004338)2.52547227
53Abnormal protein glycosylation (HP:0012346)2.51876508
54Abnormal glycosylation (HP:0012345)2.51876508
55Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.51876508
56Abnormal protein N-linked glycosylation (HP:0012347)2.51876508
57Cerebral hypomyelination (HP:0006808)2.51714406
58Poor suck (HP:0002033)2.49524967
59Leukodystrophy (HP:0002415)2.48793041
60Exertional dyspnea (HP:0002875)2.45253657
61Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.44034629
62Abnormality of serum amino acid levels (HP:0003112)2.38227042
63Hyperammonemia (HP:0001987)2.31331748
64Delusions (HP:0000746)2.30208875
65Abnormality of fatty-acid metabolism (HP:0004359)2.29500811
66Progressive muscle weakness (HP:0003323)2.26645668
67Abnormality of serine family amino acid metabolism (HP:0010894)2.24276702
68Abnormality of glycine metabolism (HP:0010895)2.24276702
69Visual hallucinations (HP:0002367)2.21916761
70Unsteady gait (HP:0002317)2.19899228
71Rough bone trabeculation (HP:0100670)2.18508401
72Muscle fiber atrophy (HP:0100295)2.16862769
73Ketosis (HP:0001946)2.16790260
74Calf muscle hypertrophy (HP:0008981)2.15961238
75Muscle hypertrophy of the lower extremities (HP:0008968)2.13791458
76Type 2 muscle fiber atrophy (HP:0003554)2.12059321
77Focal motor seizures (HP:0011153)2.11947908
78Cleft eyelid (HP:0000625)2.11511296
79Methylmalonic acidemia (HP:0002912)2.11124009
80* Gliosis (HP:0002171)2.10346701
81Myoglobinuria (HP:0002913)2.10286297
82Hypoglycemic seizures (HP:0002173)2.05903357
83Neoplasm of the adrenal gland (HP:0100631)2.05881569
84Delayed CNS myelination (HP:0002188)2.04938533
85Pancytopenia (HP:0001876)2.03530969
86Opisthotonus (HP:0002179)2.03343897
87Absent thumb (HP:0009777)1.99891005
88Renal cortical cysts (HP:0000803)1.99658526
89Meckel diverticulum (HP:0002245)1.99636927
90Abnormality of urine glucose concentration (HP:0011016)1.99610479
91Glycosuria (HP:0003076)1.99610479
92Ketoacidosis (HP:0001993)1.99254263
93Type I transferrin isoform profile (HP:0003642)1.99052984
94Prominent metopic ridge (HP:0005487)1.98509945
95Hyperphosphaturia (HP:0003109)1.98161789
96Hyperglycinuria (HP:0003108)1.97239930
97Hypoplasia of the capital femoral epiphysis (HP:0003090)1.97236694
98* Metabolic acidosis (HP:0001942)1.93487922
99Multiple enchondromatosis (HP:0005701)1.92746110
100Vomiting (HP:0002013)1.91875422
101Oral leukoplakia (HP:0002745)1.91478021
102X-linked dominant inheritance (HP:0001423)1.91004210
103Spastic paraparesis (HP:0002313)1.90826517
104* Rhabdomyolysis (HP:0003201)1.90700324
105Abnormality of the preputium (HP:0100587)1.89709028
106Sudden death (HP:0001699)1.89613492
107Reduced antithrombin III activity (HP:0001976)1.88155405
108CNS hypomyelination (HP:0003429)1.86558779
109Palpitations (HP:0001962)1.86549160
110Retinal dysplasia (HP:0007973)1.85811169
111Brushfield spots (HP:0001088)1.85798292
112Abnormality of the ileum (HP:0001549)1.85298050
113Abnormality of placental membranes (HP:0011409)1.84490591
114Amniotic constriction ring (HP:0009775)1.84490591
115Abnormality of renal resorption (HP:0011038)1.84350914
116Hypothermia (HP:0002045)1.83435320
117Colon cancer (HP:0003003)1.81896671
118Abnormal pupillary function (HP:0007686)1.81327491
119Hypobetalipoproteinemia (HP:0003563)1.80621628
120Abnormality of DNA repair (HP:0003254)1.79660641
121Thrombocytosis (HP:0001894)1.77915703
122Abnormality of the anterior horn cell (HP:0006802)1.77521288
123Degeneration of anterior horn cells (HP:0002398)1.77521288
124Pheochromocytoma (HP:0002666)1.75185117
125Hyperinsulinemic hypoglycemia (HP:0000825)1.74162451
126Generalized aminoaciduria (HP:0002909)1.73946937
127Abnormality of the metopic suture (HP:0005556)1.73732061
128Neoplasm of the adrenal cortex (HP:0100641)1.73657955
129Neuroendocrine neoplasm (HP:0100634)1.73299074
130Esophageal neoplasm (HP:0100751)1.72738105
131Neoplasm of head and neck (HP:0012288)1.72738105
132Postnatal microcephaly (HP:0005484)1.69312700
133Aplasia/Hypoplasia of the sacrum (HP:0008517)1.66768711
134Megaloblastic anemia (HP:0001889)1.66497535
135Secondary amenorrhea (HP:0000869)1.64028720
136Neoplasm of the peripheral nervous system (HP:0100007)1.60864538

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.19877847
2STK164.13367976
3BUB14.04447053
4NME23.86550633
5BCKDK3.32625619
6MAP3K123.19083037
7WEE13.13619980
8EIF2AK12.69306015
9NME12.66023264
10ZAK2.55284457
11PDK42.54626238
12PDK32.54626238
13FLT32.54605946
14BMPR1B2.43730754
15MAP4K22.05826306
16TRIM282.03911254
17VRK11.95595800
18CASK1.87064993
19TTK1.81647084
20CCNB11.80077906
21PBK1.79116344
22MYLK1.78265077
23TSSK61.75237351
24PIM21.69644353
25CDK191.58748752
26MAP2K71.58600184
27TESK21.57115633
28EIF2AK31.54426677
29BRSK21.52528288
30ATR1.50559220
31NUAK11.41876389
32SRPK11.41179012
33MAPKAPK51.40146155
34MAP3K111.38564017
35PNCK1.38485738
36MST41.38461393
37TLK11.37515718
38MUSK1.37224942
39NEK11.32982093
40ADRBK21.15969513
41TAF11.15928595
42PDK21.11953893
43GRK71.11618591
44OBSCN1.07884865
45KIT1.07471229
46CHEK21.07339622
47TNIK1.05851034
48DAPK11.05668212
49AURKA1.01135570
50ILK1.00484699
51TAOK20.99671486
52MAP3K40.97854943
53BRSK10.97520537
54LIMK10.96998678
55CDK80.96162582
56TESK10.95763161
57MAPK130.95565935
58MAP2K40.95086457
59TGFBR10.92206868
60SMG10.90575564
61RPS6KB20.88557850
62MKNK10.86639687
63GRK60.83343256
64CSNK1G30.79953346
65UHMK10.76654867
66PKN20.75363432
67CHEK10.74858379
68CDC70.74687755
69FES0.74316976
70BTK0.74072958
71CSNK2A20.72013806
72LRRK20.70663665
73TIE10.69443215
74PHKG10.68567760
75PHKG20.68567760
76ATM0.68335296
77CSNK1A1L0.68283465
78EEF2K0.66613934
79CAMK10.66231563
80SYK0.65708970
81CDK90.63677368
82DYRK30.62883490
83CSNK2A10.62611075
84TEC0.62300402
85MAPKAPK30.61247471
86PRKCI0.60236317
87MAPK40.58847948
88MAP3K60.58595720
89MAP2K60.58534219
90SCYL20.58189445
91RAF10.57898885
92MKNK20.57617980
93EIF2AK20.57285216
94PLK10.56782873
95ZAP700.55719267
96AKT20.55679183
97LMTK20.55646018
98RPS6KA50.54648154
99ADRBK10.54210893
100MAP3K80.52550325
101MAP4K10.51770091
102DAPK30.49979449
103MAP2K30.49570875
104MINK10.49358792
105PLK30.49113906
106RPS6KA40.48143444
107CSNK1G20.47413125
108KDR0.47254839
109CDK40.47037716
110ABL20.46522455
111PASK0.45648817
112PIK3CG0.45395147
113PLK40.44959839
114AURKB0.44558697
115GRK50.44068639
116PRKD30.43787986
117MAP3K50.43517837
118MATK0.41806024
119ARAF0.40269656
120STK40.38361981
121CAMK2B0.38173196
122CDK20.38022803
123MAPK120.37601061
124ACVR1B0.37071732
125NTRK30.36386372
126CSNK1G10.36191529
127PAK10.35788206
128DYRK20.35305271
129CDK10.35271089
130CDK70.34288657
131CAMKK20.33606966
132CSNK1E0.32787094
133PINK10.31015815
134CAMK2D0.30826458
135CAMK2A0.30509385
136PRKCG0.30295088
137PRKDC0.29880168
138BRAF0.29473443
139STK390.28316321
140ALK0.26463031
141CDK11A0.25719292
142ERBB30.25647788
143CDK180.23383901
144CDK140.23354501
145CDK150.23280105
146CSNK1A10.23058060

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.70470899
2Oxidative phosphorylation_Homo sapiens_hsa001904.11817619
3Parkinsons disease_Homo sapiens_hsa050123.87532785
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.43181360
5Proteasome_Homo sapiens_hsa030503.26954059
6RNA polymerase_Homo sapiens_hsa030202.66534947
7Alzheimers disease_Homo sapiens_hsa050102.63300605
8Huntingtons disease_Homo sapiens_hsa050162.56847540
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.41193092
10DNA replication_Homo sapiens_hsa030302.39659090
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.22311133
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.19689211
13Mismatch repair_Homo sapiens_hsa034302.08117175
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.99789754
15Protein export_Homo sapiens_hsa030601.99082653
16Pyruvate metabolism_Homo sapiens_hsa006201.97526195
17Pyrimidine metabolism_Homo sapiens_hsa002401.93522225
18Propanoate metabolism_Homo sapiens_hsa006401.82033481
19Cardiac muscle contraction_Homo sapiens_hsa042601.77268075
20Base excision repair_Homo sapiens_hsa034101.66763736
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.63786598
22Carbon metabolism_Homo sapiens_hsa012001.62525530
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60010579
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.54214897
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.53774480
26Folate biosynthesis_Homo sapiens_hsa007901.51904075
27Homologous recombination_Homo sapiens_hsa034401.50284463
28Spliceosome_Homo sapiens_hsa030401.46485707
29Sulfur relay system_Homo sapiens_hsa041221.44647369
30Fatty acid elongation_Homo sapiens_hsa000621.44220857
31Fatty acid degradation_Homo sapiens_hsa000711.41282276
32Nucleotide excision repair_Homo sapiens_hsa034201.34862792
33Biosynthesis of amino acids_Homo sapiens_hsa012301.28289542
34Butanoate metabolism_Homo sapiens_hsa006501.27911530
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.26503225
36Purine metabolism_Homo sapiens_hsa002301.24627621
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.21571912
38Vitamin B6 metabolism_Homo sapiens_hsa007501.19648757
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17582073
40RNA transport_Homo sapiens_hsa030131.14539369
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.11347758
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.09067163
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98532880
44Drug metabolism - other enzymes_Homo sapiens_hsa009830.96216649
45One carbon pool by folate_Homo sapiens_hsa006700.95368493
46Sulfur metabolism_Homo sapiens_hsa009200.92377935
47Metabolic pathways_Homo sapiens_hsa011000.92360349
48Peroxisome_Homo sapiens_hsa041460.91501231
49Basal transcription factors_Homo sapiens_hsa030220.90826695
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88368268
51Fatty acid metabolism_Homo sapiens_hsa012120.86206413
52Pentose phosphate pathway_Homo sapiens_hsa000300.85775278
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.85528606
54Steroid biosynthesis_Homo sapiens_hsa001000.82391593
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.75472624
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74175079
57Arginine and proline metabolism_Homo sapiens_hsa003300.73823894
58beta-Alanine metabolism_Homo sapiens_hsa004100.72796821
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.68454867
60Tryptophan metabolism_Homo sapiens_hsa003800.66833360
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66556992
62mRNA surveillance pathway_Homo sapiens_hsa030150.61545024
63Non-homologous end-joining_Homo sapiens_hsa034500.60274345
64RNA degradation_Homo sapiens_hsa030180.60149834
65Arginine biosynthesis_Homo sapiens_hsa002200.56104058
66Selenocompound metabolism_Homo sapiens_hsa004500.55995238
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55611288
68Glutathione metabolism_Homo sapiens_hsa004800.53843049
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51029748
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50257532
71p53 signaling pathway_Homo sapiens_hsa041150.48234094
72Tyrosine metabolism_Homo sapiens_hsa003500.46312739
73Vibrio cholerae infection_Homo sapiens_hsa051100.45277377
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43462103
75Phenylalanine metabolism_Homo sapiens_hsa003600.40352753
76Cell cycle_Homo sapiens_hsa041100.40062595
77Nicotine addiction_Homo sapiens_hsa050330.40047708
78N-Glycan biosynthesis_Homo sapiens_hsa005100.39343224
79Fanconi anemia pathway_Homo sapiens_hsa034600.39299496
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38664305
81Galactose metabolism_Homo sapiens_hsa000520.37545747
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35456275
83Phototransduction_Homo sapiens_hsa047440.31719886
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30902865
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30350712
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29635804
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.29614399
88Regulation of autophagy_Homo sapiens_hsa041400.29006146
89Fructose and mannose metabolism_Homo sapiens_hsa000510.27417858
90Collecting duct acid secretion_Homo sapiens_hsa049660.25203896
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25113292
92Starch and sucrose metabolism_Homo sapiens_hsa005000.24493580
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23567140
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.23510796
95PPAR signaling pathway_Homo sapiens_hsa033200.23213680
96Histidine metabolism_Homo sapiens_hsa003400.21903364
97Chemical carcinogenesis_Homo sapiens_hsa052040.20961493
98Lysine degradation_Homo sapiens_hsa003100.18221204
99Epstein-Barr virus infection_Homo sapiens_hsa051690.18153102
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.17608125
101Oocyte meiosis_Homo sapiens_hsa041140.16627047
102Taste transduction_Homo sapiens_hsa047420.16338832
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.16079782
104Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.14695539
105Retinol metabolism_Homo sapiens_hsa008300.13659595
106Glucagon signaling pathway_Homo sapiens_hsa049220.13238217
107Systemic lupus erythematosus_Homo sapiens_hsa053220.12451426
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.12133946
109Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.09618999
110Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.09384694
111GABAergic synapse_Homo sapiens_hsa047270.08713597
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.07753927
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.07743235

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