Rank | Gene Set | Z-score |
---|---|---|
1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 7.23232419 |
2 | ATP synthesis coupled proton transport (GO:0015986) | 6.48120228 |
3 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 6.48120228 |
4 | ribosomal small subunit assembly (GO:0000028) | 6.13578281 |
5 | viral transcription (GO:0019083) | 6.02694143 |
6 | translational termination (GO:0006415) | 5.88932617 |
7 | ribosomal small subunit biogenesis (GO:0042274) | 5.70482877 |
8 | maturation of SSU-rRNA (GO:0030490) | 5.58271384 |
9 | respiratory electron transport chain (GO:0022904) | 5.30940498 |
10 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 5.22486733 |
11 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 5.22219060 |
12 | electron transport chain (GO:0022900) | 5.21628110 |
13 | cotranslational protein targeting to membrane (GO:0006613) | 5.19799829 |
14 | translational elongation (GO:0006414) | 5.19494988 |
15 | protein targeting to ER (GO:0045047) | 5.12985011 |
16 | oxidative phosphorylation (GO:0006119) | 5.00346164 |
17 | protein localization to endoplasmic reticulum (GO:0070972) | 4.94512416 |
18 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.89841323 |
19 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 4.72073778 |
20 | cellular protein complex disassembly (GO:0043624) | 4.69002620 |
21 | NADH metabolic process (GO:0006734) | 4.67100025 |
22 | translational initiation (GO:0006413) | 4.49706518 |
23 | viral life cycle (GO:0019058) | 4.46343734 |
24 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.40606729 |
25 | ribosomal large subunit biogenesis (GO:0042273) | 4.25671916 |
26 | * mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.24642321 |
27 | * mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.24642321 |
28 | * NADH dehydrogenase complex assembly (GO:0010257) | 4.24642321 |
29 | * protein complex biogenesis (GO:0070271) | 4.20883949 |
30 | chaperone-mediated protein transport (GO:0072321) | 4.13572398 |
31 | L-methionine salvage (GO:0071267) | 4.06132906 |
32 | L-methionine biosynthetic process (GO:0071265) | 4.06132906 |
33 | amino acid salvage (GO:0043102) | 4.06132906 |
34 | proteasome assembly (GO:0043248) | 4.04236422 |
35 | translation (GO:0006412) | 3.98804557 |
36 | protein complex disassembly (GO:0043241) | 3.97905394 |
37 | * mitochondrial respiratory chain complex assembly (GO:0033108) | 3.93887781 |
38 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.91241187 |
39 | cullin deneddylation (GO:0010388) | 3.88095856 |
40 | tricarboxylic acid cycle (GO:0006099) | 3.86483206 |
41 | protein deneddylation (GO:0000338) | 3.85941063 |
42 | DNA strand elongation (GO:0022616) | 3.83599366 |
43 | ubiquinone biosynthetic process (GO:0006744) | 3.82357600 |
44 | quinone biosynthetic process (GO:1901663) | 3.82357600 |
45 | regulation of mitochondrial translation (GO:0070129) | 3.82228587 |
46 | macromolecular complex disassembly (GO:0032984) | 3.80699845 |
47 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.79845140 |
48 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.70449596 |
49 | maturation of 5.8S rRNA (GO:0000460) | 3.69991206 |
50 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.69519975 |
51 | inner mitochondrial membrane organization (GO:0007007) | 3.67962077 |
52 | * cellular component biogenesis (GO:0044085) | 3.63746574 |
53 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.57286190 |
54 | peptidyl-histidine modification (GO:0018202) | 3.53731221 |
55 | pseudouridine synthesis (GO:0001522) | 3.53139568 |
56 | * respiratory chain complex IV assembly (GO:0008535) | 3.52056391 |
57 | DNA deamination (GO:0045006) | 3.52021136 |
58 | GTP biosynthetic process (GO:0006183) | 3.51494032 |
59 | ribosome assembly (GO:0042255) | 3.50975567 |
60 | aerobic respiration (GO:0009060) | 3.50283484 |
61 | regulation of acyl-CoA biosynthetic process (GO:0050812) | 3.49002395 |
62 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.44708217 |
63 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.44371360 |
64 | protein targeting to membrane (GO:0006612) | 3.43849112 |
65 | transcription from mitochondrial promoter (GO:0006390) | 3.43542165 |
66 | oxaloacetate metabolic process (GO:0006107) | 3.42965133 |
67 | ATP biosynthetic process (GO:0006754) | 3.42769413 |
68 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.41904764 |
69 | protein targeting to mitochondrion (GO:0006626) | 3.39611034 |
70 | mitochondrial RNA metabolic process (GO:0000959) | 3.37714782 |
71 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.36727805 |
72 | metallo-sulfur cluster assembly (GO:0031163) | 3.36201020 |
73 | iron-sulfur cluster assembly (GO:0016226) | 3.36201020 |
74 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.35258594 |
75 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.34115719 |
76 | ubiquinone metabolic process (GO:0006743) | 3.33773837 |
77 | regulation of cofactor metabolic process (GO:0051193) | 3.32564008 |
78 | regulation of coenzyme metabolic process (GO:0051196) | 3.32564008 |
79 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 3.30460920 |
80 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.29283020 |
81 | establishment of protein localization to mitochondrion (GO:0072655) | 3.29166078 |
82 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 3.28919503 |
83 | spliceosomal snRNP assembly (GO:0000387) | 3.28747861 |
84 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.28013486 |
85 | succinate metabolic process (GO:0006105) | 3.27795792 |
86 | DNA damage response, detection of DNA damage (GO:0042769) | 3.27464769 |
87 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.25609753 |
88 | regulation of oxidative phosphorylation (GO:0002082) | 3.24902903 |
89 | UTP biosynthetic process (GO:0006228) | 3.24663350 |
90 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.24521247 |
91 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.24521247 |
92 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.24521247 |
93 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.23274918 |
94 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 3.21756576 |
95 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.21554874 |
96 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.21554874 |
97 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.20271431 |
98 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.20206254 |
99 | termination of RNA polymerase III transcription (GO:0006386) | 3.20206254 |
100 | telomere maintenance via recombination (GO:0000722) | 3.19121055 |
101 | UTP metabolic process (GO:0046051) | 3.18967649 |
102 | nucleobase biosynthetic process (GO:0046112) | 3.18646486 |
103 | rRNA modification (GO:0000154) | 3.17648194 |
104 | base-excision repair, AP site formation (GO:0006285) | 3.17410850 |
105 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.17067629 |
106 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.17067629 |
107 | establishment of integrated proviral latency (GO:0075713) | 3.16003258 |
108 | protein maturation by protein folding (GO:0022417) | 3.15380669 |
109 | tRNA processing (GO:0008033) | 3.15222009 |
110 | protein localization to mitochondrion (GO:0070585) | 3.13813121 |
111 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.13501415 |
112 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.12150706 |
113 | pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209) | 3.11549821 |
114 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.10935086 |
115 | mitochondrial transport (GO:0006839) | 3.09551077 |
116 | tRNA metabolic process (GO:0006399) | 3.09462793 |
117 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.07983880 |
118 | ribosome biogenesis (GO:0042254) | 3.07511515 |
119 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.06871878 |
120 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.06056422 |
121 | rRNA methylation (GO:0031167) | 3.05887214 |
122 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.05665086 |
123 | purine nucleobase biosynthetic process (GO:0009113) | 3.05480498 |
124 | mitotic recombination (GO:0006312) | 3.05431803 |
125 | histone H2A acetylation (GO:0043968) | 3.04883649 |
126 | tRNA modification (GO:0006400) | 3.04816098 |
127 | dopamine transport (GO:0015872) | 3.04762016 |
128 | rRNA processing (GO:0006364) | 3.04232986 |
129 | amino acid activation (GO:0043038) | 3.04043129 |
130 | tRNA aminoacylation (GO:0043039) | 3.04043129 |
131 | purine ribonucleoside monophosphate biosynthetic process (GO:0009168) | 3.02110891 |
132 | purine nucleoside monophosphate biosynthetic process (GO:0009127) | 3.02110891 |
133 | CTP biosynthetic process (GO:0006241) | 3.01942974 |
134 | CTP metabolic process (GO:0046036) | 3.01942974 |
135 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.98114945 |
136 | negative regulation of ligase activity (GO:0051352) | 2.98114945 |
137 | formation of translation preinitiation complex (GO:0001731) | 2.95457492 |
138 | mRNA catabolic process (GO:0006402) | 2.92671849 |
139 | rRNA metabolic process (GO:0016072) | 2.91786576 |
140 | pteridine-containing compound biosynthetic process (GO:0042559) | 2.90752691 |
141 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.89502606 |
142 | cellular respiration (GO:0045333) | 2.89072210 |
143 | * cytochrome complex assembly (GO:0017004) | 2.89016553 |
144 | DNA strand elongation involved in DNA replication (GO:0006271) | 2.87771197 |
145 | methionine metabolic process (GO:0006555) | 2.86070554 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.76028575 |
2 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 4.49643143 |
3 | * KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.43902517 |
4 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 4.04849056 |
5 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.04482540 |
6 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.04431043 |
7 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.94470497 |
8 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.80980340 |
9 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.53126181 |
10 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.41082991 |
11 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.40977445 |
12 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.35165562 |
13 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.34163191 |
14 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.00308727 |
15 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.82835002 |
16 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.75398922 |
17 | * THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.72572341 |
18 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.68578572 |
19 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.68112327 |
20 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.66008387 |
21 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.49994657 |
22 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.48048266 |
23 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.44636152 |
24 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.43630040 |
25 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.37777662 |
26 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.31512141 |
27 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.27368606 |
28 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.26592811 |
29 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 2.24487255 |
30 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.22557966 |
31 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.18638021 |
32 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.15921217 |
33 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.05279771 |
34 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 2.00878377 |
35 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.96071076 |
36 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.91582931 |
37 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.91404451 |
38 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.88838021 |
39 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.86004451 |
40 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.85738387 |
41 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.79960310 |
42 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.76756157 |
43 | * SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.75499014 |
44 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.71342428 |
45 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.68575184 |
46 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.66985413 |
47 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.66277590 |
48 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.65228228 |
49 | * FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.64947145 |
50 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.62690623 |
51 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.61725918 |
52 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.60684577 |
53 | * POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.60358086 |
54 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.58985666 |
55 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.50460864 |
56 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.50062752 |
57 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.45311650 |
58 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.45296554 |
59 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.41679584 |
60 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.41421083 |
61 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.37337342 |
62 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.36620321 |
63 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.36608164 |
64 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.35709935 |
65 | * CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.29843299 |
66 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.25457590 |
67 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.24189488 |
68 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.22263213 |
69 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.19183200 |
70 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.17308729 |
71 | * SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.16562525 |
72 | GATA1_22025678_ChIP-Seq_K562_Human | 1.16037334 |
73 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.11786294 |
74 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.10312073 |
75 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.09614099 |
76 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.09472701 |
77 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.06388700 |
78 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.05975920 |
79 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.05511206 |
80 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.05168390 |
81 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.05051316 |
82 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.04654748 |
83 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.02896109 |
84 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.01494647 |
85 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.98205783 |
86 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.96378498 |
87 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.93396586 |
88 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.93009180 |
89 | * GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.91757693 |
90 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.91067310 |
91 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.90463356 |
92 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.88037127 |
93 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.87757475 |
94 | * SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.86052245 |
95 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.85648367 |
96 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.85338760 |
97 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.84975950 |
98 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.84183975 |
99 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.84124448 |
100 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.83912614 |
101 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.83037625 |
102 | * CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.81428408 |
103 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.81075583 |
104 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.80862333 |
105 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.79003624 |
106 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.78475692 |
107 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 0.78233964 |
108 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.77188343 |
109 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.76610293 |
110 | * KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.72554834 |
111 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.72547243 |
112 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.72239619 |
113 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.71192736 |
114 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.69573794 |
115 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.68646601 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0009379_abnormal_foot_pigmentation | 5.45132362 |
2 | MP0002837_dystrophic_cardiac_calcinosis | 4.04537532 |
3 | MP0006036_abnormal_mitochondrial_physio | 3.51158070 |
4 | MP0001529_abnormal_vocalization | 3.45495826 |
5 | MP0003806_abnormal_nucleotide_metabolis | 3.20884617 |
6 | MP0003646_muscle_fatigue | 2.78347996 |
7 | MP0006292_abnormal_olfactory_placode | 2.60874483 |
8 | MP0008007_abnormal_cellular_replicative | 2.57981716 |
9 | MP0008789_abnormal_olfactory_epithelium | 2.45494373 |
10 | MP0006035_abnormal_mitochondrial_morpho | 2.38209266 |
11 | MP0004957_abnormal_blastocyst_morpholog | 2.26952246 |
12 | MP0004215_abnormal_myocardial_fiber | 2.24562789 |
13 | MP0000751_myopathy | 2.18499151 |
14 | MP0000749_muscle_degeneration | 2.17954406 |
15 | MP0002139_abnormal_hepatobiliary_system | 2.13130050 |
16 | MP0004147_increased_porphyrin_level | 2.07702405 |
17 | MP0005085_abnormal_gallbladder_physiolo | 1.90745086 |
18 | MP0005394_taste/olfaction_phenotype | 1.88614878 |
19 | MP0005499_abnormal_olfactory_system | 1.88614878 |
20 | MP0005330_cardiomyopathy | 1.83667775 |
21 | MP0002638_abnormal_pupillary_reflex | 1.80587507 |
22 | MP0002736_abnormal_nociception_after | 1.78718787 |
23 | MP0003186_abnormal_redox_activity | 1.76321285 |
24 | MP0001905_abnormal_dopamine_level | 1.74037241 |
25 | MP0000747_muscle_weakness | 1.71724593 |
26 | MP0005360_urolithiasis | 1.68502070 |
27 | MP0005365_abnormal_bile_salt | 1.65114297 |
28 | MP0010094_abnormal_chromosome_stability | 1.64291589 |
29 | MP0001764_abnormal_homeostasis | 1.64255611 |
30 | MP0000372_irregular_coat_pigmentation | 1.63120290 |
31 | MP0004036_abnormal_muscle_relaxation | 1.62789057 |
32 | MP0003880_abnormal_central_pattern | 1.61759875 |
33 | MP0001986_abnormal_taste_sensitivity | 1.58123899 |
34 | MP0004084_abnormal_cardiac_muscle | 1.57319875 |
35 | MP0003693_abnormal_embryo_hatching | 1.56907891 |
36 | MP0004142_abnormal_muscle_tone | 1.53023508 |
37 | MP0002822_catalepsy | 1.52751365 |
38 | MP0003123_paternal_imprinting | 1.50607130 |
39 | MP0005084_abnormal_gallbladder_morpholo | 1.50204205 |
40 | MP0002163_abnormal_gland_morphology | 1.47453309 |
41 | MP0003786_premature_aging | 1.47347559 |
42 | MP0001968_abnormal_touch/_nociception | 1.46828687 |
43 | MP0002396_abnormal_hematopoietic_system | 1.46171045 |
44 | MP0001188_hyperpigmentation | 1.46107483 |
45 | MP0005266_abnormal_metabolism | 1.44742853 |
46 | MP0003656_abnormal_erythrocyte_physiolo | 1.43149793 |
47 | MP0004145_abnormal_muscle_electrophysio | 1.41373044 |
48 | MP0009697_abnormal_copulation | 1.38355568 |
49 | MP0003567_abnormal_fetal_cardiomyocyte | 1.37042048 |
50 | MP0006276_abnormal_autonomic_nervous | 1.33860328 |
51 | MP0005332_abnormal_amino_acid | 1.33580421 |
52 | MP0008058_abnormal_DNA_repair | 1.32936088 |
53 | MP0002102_abnormal_ear_morphology | 1.30427796 |
54 | MP0002132_abnormal_respiratory_system | 1.28610663 |
55 | MP0004484_altered_response_of | 1.27906782 |
56 | MP0000313_abnormal_cell_death | 1.27673524 |
57 | MP0008875_abnormal_xenobiotic_pharmacok | 1.27563782 |
58 | MP0005174_abnormal_tail_pigmentation | 1.26204163 |
59 | MP0005645_abnormal_hypothalamus_physiol | 1.25845638 |
60 | MP0001730_embryonic_growth_arrest | 1.24468766 |
61 | MP0002160_abnormal_reproductive_system | 1.24329385 |
62 | MP0005584_abnormal_enzyme/coenzyme_acti | 1.23668115 |
63 | MP0003011_delayed_dark_adaptation | 1.23519951 |
64 | MP0003137_abnormal_impulse_conducting | 1.22465317 |
65 | MP0009745_abnormal_behavioral_response | 1.22309148 |
66 | MP0008932_abnormal_embryonic_tissue | 1.21041398 |
67 | MP0008872_abnormal_physiological_respon | 1.20699125 |
68 | MP0005636_abnormal_mineral_homeostasis | 1.20389051 |
69 | MP0005397_hematopoietic_system_phenotyp | 1.19402215 |
70 | MP0001545_abnormal_hematopoietic_system | 1.19402215 |
71 | MP0003221_abnormal_cardiomyocyte_apopto | 1.17610713 |
72 | MP0003077_abnormal_cell_cycle | 1.17610507 |
73 | MP0005220_abnormal_exocrine_pancreas | 1.16813433 |
74 | MP0003718_maternal_effect | 1.16500170 |
75 | MP0005075_abnormal_melanosome_morpholog | 1.14932325 |
76 | MP0003195_calcinosis | 1.13795626 |
77 | MP0002210_abnormal_sex_determination | 1.10749170 |
78 | MP0002106_abnormal_muscle_physiology | 1.09313342 |
79 | MP0003111_abnormal_nucleus_morphology | 1.09032278 |
80 | MP0002080_prenatal_lethality | 1.08362358 |
81 | MP0002095_abnormal_skin_pigmentation | 1.07358037 |
82 | MP0002234_abnormal_pharynx_morphology | 1.07169405 |
83 | MP0000350_abnormal_cell_proliferation | 1.06715489 |
84 | MP0005376_homeostasis/metabolism_phenot | 1.04525220 |
85 | MP0001697_abnormal_embryo_size | 1.04200974 |
86 | MP0004130_abnormal_muscle_cell | 1.04101822 |
87 | MP0001929_abnormal_gametogenesis | 1.02065395 |
88 | MP0002272_abnormal_nervous_system | 1.01989418 |
89 | MP0003315_abnormal_perineum_morphology | 0.97659110 |
90 | MP0000358_abnormal_cell_content/ | 0.97024615 |
91 | MP0001145_abnormal_male_reproductive | 0.95766797 |
92 | MP0005319_abnormal_enzyme/_coenzyme | 0.95747447 |
93 | MP0005620_abnormal_muscle_contractility | 0.95712427 |
94 | MP0002269_muscular_atrophy | 0.95347333 |
95 | MP0001293_anophthalmia | 0.94783848 |
96 | MP0000750_abnormal_muscle_regeneration | 0.94623826 |
97 | MP0006072_abnormal_retinal_apoptosis | 0.94408737 |
98 | MP0002938_white_spotting | 0.94287968 |
99 | MP0002019_abnormal_tumor_incidence | 0.94186300 |
100 | MP0003635_abnormal_synaptic_transmissio | 0.94081828 |
101 | MP0005535_abnormal_body_temperature | 0.92894225 |
102 | MP0001501_abnormal_sleep_pattern | 0.91617287 |
103 | MP0002972_abnormal_cardiac_muscle | 0.91374861 |
104 | MP0000653_abnormal_sex_gland | 0.88861194 |
105 | MP0001544_abnormal_cardiovascular_syste | 0.87944076 |
106 | MP0005385_cardiovascular_system_phenoty | 0.87944076 |
107 | MP0003122_maternal_imprinting | 0.87808709 |
108 | MP0005369_muscle_phenotype | 0.87323597 |
109 | MP0005670_abnormal_white_adipose | 0.86726899 |
110 | MP0001853_heart_inflammation | 0.85524501 |
111 | MP0001672_abnormal_embryogenesis/_devel | 0.85244395 |
112 | MP0005380_embryogenesis_phenotype | 0.85244395 |
113 | MP0010329_abnormal_lipoprotein_level | 0.84794789 |
114 | MP0001440_abnormal_grooming_behavior | 0.84703035 |
115 | MP0001661_extended_life_span | 0.81623618 |
116 | MP0001727_abnormal_embryo_implantation | 0.80938102 |
117 | MP0002064_seizures | 0.79374194 |
118 | MP0004233_abnormal_muscle_weight | 0.78183230 |
119 | MP0010030_abnormal_orbit_morphology | 0.75865775 |
120 | MP0002572_abnormal_emotion/affect_behav | 0.75704372 |
121 | MP0005423_abnormal_somatic_nervous | 0.75394599 |
122 | MP0000759_abnormal_skeletal_muscle | 0.74032925 |
123 | MP0004085_abnormal_heartbeat | 0.73073292 |
124 | MP0008873_increased_physiological_sensi | 0.71624914 |
125 | MP0000049_abnormal_middle_ear | 0.70294513 |
126 | MP0005379_endocrine/exocrine_gland_phen | 0.69658003 |
127 | MP0002085_abnormal_embryonic_tissue | 0.69143529 |
128 | MP0004087_abnormal_muscle_fiber | 0.69006324 |
129 | MP0002078_abnormal_glucose_homeostasis | 0.68272652 |
130 | MP0003698_abnormal_male_reproductive | 0.68140957 |
131 | MP0008057_abnormal_DNA_replication | 0.67996308 |
132 | MP0008995_early_reproductive_senescence | 0.67617167 |
133 | MP0003984_embryonic_growth_retardation | 0.66303289 |
134 | MP0000230_abnormal_systemic_arterial | 0.66075438 |
135 | MP0002735_abnormal_chemical_nociception | 0.65916395 |
136 | MP0002063_abnormal_learning/memory/cond | 0.65890118 |
137 | MP0001119_abnormal_female_reproductive | 0.65696866 |
138 | MP0002332_abnormal_exercise_endurance | 0.65282626 |
139 | MP0005551_abnormal_eye_electrophysiolog | 0.64855117 |
140 | MP0002088_abnormal_embryonic_growth/wei | 0.64482952 |
141 | MP0008877_abnormal_DNA_methylation | 0.63701486 |
142 | MP0002067_abnormal_sensory_capabilities | 0.63404062 |
143 | MP0004924_abnormal_behavior | 0.63144048 |
144 | MP0005386_behavior/neurological_phenoty | 0.63144048 |
145 | MP0003868_abnormal_feces_composition | 0.62764727 |
146 | MP0005389_reproductive_system_phenotype | 0.62287912 |
147 | MP0001984_abnormal_olfaction | 0.62053348 |
148 | MP0003950_abnormal_plasma_membrane | 0.61143814 |
149 | MP0000015_abnormal_ear_pigmentation | 0.60796556 |
150 | MP0003385_abnormal_body_wall | 0.60774418 |
151 | MP0002249_abnormal_larynx_morphology | 0.60251785 |
152 | MP0005501_abnormal_skin_physiology | 0.60164028 |
153 | MP0002084_abnormal_developmental_patter | 0.59401310 |
154 | MP0000490_abnormal_crypts_of | 0.58959227 |
155 | MP0005452_abnormal_adipose_tissue | 0.58816056 |
156 | MP0003121_genomic_imprinting | 0.57546341 |
157 | MP0000678_abnormal_parathyroid_gland | 0.57221461 |
158 | MP0005384_cellular_phenotype | 0.56895807 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Acute necrotizing encephalopathy (HP:0006965) | 5.59784552 |
2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 5.47004629 |
3 | * Mitochondrial inheritance (HP:0001427) | 5.28926859 |
4 | * Hepatocellular necrosis (HP:0001404) | 5.27829305 |
5 | Acute encephalopathy (HP:0006846) | 5.10560826 |
6 | * Increased CSF lactate (HP:0002490) | 5.03262115 |
7 | * Hepatic necrosis (HP:0002605) | 4.93134533 |
8 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 4.56751618 |
9 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 4.56751618 |
10 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.56475001 |
11 | Abnormal number of erythroid precursors (HP:0012131) | 4.51589798 |
12 | Progressive macrocephaly (HP:0004481) | 4.48589078 |
13 | Increased hepatocellular lipid droplets (HP:0006565) | 4.24382721 |
14 | Lipid accumulation in hepatocytes (HP:0006561) | 4.23735456 |
15 | * Increased serum pyruvate (HP:0003542) | 4.17053562 |
16 | * Abnormality of glycolysis (HP:0004366) | 4.17053562 |
17 | * Lactic acidosis (HP:0003128) | 4.01478233 |
18 | * Increased serum lactate (HP:0002151) | 4.00076455 |
19 | Cerebral edema (HP:0002181) | 3.93428346 |
20 | Increased intramyocellular lipid droplets (HP:0012240) | 3.93413727 |
21 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.88783015 |
22 | Increased muscle lipid content (HP:0009058) | 3.76140518 |
23 | Abnormality of alanine metabolism (HP:0010916) | 3.54527619 |
24 | Hyperalaninemia (HP:0003348) | 3.54527619 |
25 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.54527619 |
26 | * Exercise intolerance (HP:0003546) | 3.49577452 |
27 | * Respiratory failure (HP:0002878) | 3.41943700 |
28 | Renal Fanconi syndrome (HP:0001994) | 3.40486296 |
29 | Reticulocytopenia (HP:0001896) | 3.36612755 |
30 | Macrocytic anemia (HP:0001972) | 3.34701752 |
31 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.20663746 |
32 | Aplastic anemia (HP:0001915) | 3.19605932 |
33 | 3-Methylglutaconic aciduria (HP:0003535) | 3.15095375 |
34 | * Ragged-red muscle fibers (HP:0003200) | 3.11170017 |
35 | Respiratory difficulties (HP:0002880) | 3.01598176 |
36 | Dicarboxylic aciduria (HP:0003215) | 2.97425060 |
37 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.97425060 |
38 | Lethargy (HP:0001254) | 2.93255219 |
39 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.90183084 |
40 | * CNS demyelination (HP:0007305) | 2.90034700 |
41 | Chromsome breakage (HP:0040012) | 2.85504708 |
42 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.73952516 |
43 | Optic disc pallor (HP:0000543) | 2.68747305 |
44 | * Microvesicular hepatic steatosis (HP:0001414) | 2.67940188 |
45 | Hypoglycemic coma (HP:0001325) | 2.67001275 |
46 | Methylmalonic aciduria (HP:0012120) | 2.61766066 |
47 | Testicular atrophy (HP:0000029) | 2.59607676 |
48 | * Emotional lability (HP:0000712) | 2.59180396 |
49 | Pallor (HP:0000980) | 2.57092933 |
50 | Hyperglycinemia (HP:0002154) | 2.56365277 |
51 | Progressive microcephaly (HP:0000253) | 2.54968203 |
52 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 2.52547227 |
53 | Abnormal protein glycosylation (HP:0012346) | 2.51876508 |
54 | Abnormal glycosylation (HP:0012345) | 2.51876508 |
55 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.51876508 |
56 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.51876508 |
57 | Cerebral hypomyelination (HP:0006808) | 2.51714406 |
58 | Poor suck (HP:0002033) | 2.49524967 |
59 | Leukodystrophy (HP:0002415) | 2.48793041 |
60 | Exertional dyspnea (HP:0002875) | 2.45253657 |
61 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 2.44034629 |
62 | Abnormality of serum amino acid levels (HP:0003112) | 2.38227042 |
63 | Hyperammonemia (HP:0001987) | 2.31331748 |
64 | Delusions (HP:0000746) | 2.30208875 |
65 | Abnormality of fatty-acid metabolism (HP:0004359) | 2.29500811 |
66 | Progressive muscle weakness (HP:0003323) | 2.26645668 |
67 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.24276702 |
68 | Abnormality of glycine metabolism (HP:0010895) | 2.24276702 |
69 | Visual hallucinations (HP:0002367) | 2.21916761 |
70 | Unsteady gait (HP:0002317) | 2.19899228 |
71 | Rough bone trabeculation (HP:0100670) | 2.18508401 |
72 | Muscle fiber atrophy (HP:0100295) | 2.16862769 |
73 | Ketosis (HP:0001946) | 2.16790260 |
74 | Calf muscle hypertrophy (HP:0008981) | 2.15961238 |
75 | Muscle hypertrophy of the lower extremities (HP:0008968) | 2.13791458 |
76 | Type 2 muscle fiber atrophy (HP:0003554) | 2.12059321 |
77 | Focal motor seizures (HP:0011153) | 2.11947908 |
78 | Cleft eyelid (HP:0000625) | 2.11511296 |
79 | Methylmalonic acidemia (HP:0002912) | 2.11124009 |
80 | * Gliosis (HP:0002171) | 2.10346701 |
81 | Myoglobinuria (HP:0002913) | 2.10286297 |
82 | Hypoglycemic seizures (HP:0002173) | 2.05903357 |
83 | Neoplasm of the adrenal gland (HP:0100631) | 2.05881569 |
84 | Delayed CNS myelination (HP:0002188) | 2.04938533 |
85 | Pancytopenia (HP:0001876) | 2.03530969 |
86 | Opisthotonus (HP:0002179) | 2.03343897 |
87 | Absent thumb (HP:0009777) | 1.99891005 |
88 | Renal cortical cysts (HP:0000803) | 1.99658526 |
89 | Meckel diverticulum (HP:0002245) | 1.99636927 |
90 | Abnormality of urine glucose concentration (HP:0011016) | 1.99610479 |
91 | Glycosuria (HP:0003076) | 1.99610479 |
92 | Ketoacidosis (HP:0001993) | 1.99254263 |
93 | Type I transferrin isoform profile (HP:0003642) | 1.99052984 |
94 | Prominent metopic ridge (HP:0005487) | 1.98509945 |
95 | Hyperphosphaturia (HP:0003109) | 1.98161789 |
96 | Hyperglycinuria (HP:0003108) | 1.97239930 |
97 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.97236694 |
98 | * Metabolic acidosis (HP:0001942) | 1.93487922 |
99 | Multiple enchondromatosis (HP:0005701) | 1.92746110 |
100 | Vomiting (HP:0002013) | 1.91875422 |
101 | Oral leukoplakia (HP:0002745) | 1.91478021 |
102 | X-linked dominant inheritance (HP:0001423) | 1.91004210 |
103 | Spastic paraparesis (HP:0002313) | 1.90826517 |
104 | * Rhabdomyolysis (HP:0003201) | 1.90700324 |
105 | Abnormality of the preputium (HP:0100587) | 1.89709028 |
106 | Sudden death (HP:0001699) | 1.89613492 |
107 | Reduced antithrombin III activity (HP:0001976) | 1.88155405 |
108 | CNS hypomyelination (HP:0003429) | 1.86558779 |
109 | Palpitations (HP:0001962) | 1.86549160 |
110 | Retinal dysplasia (HP:0007973) | 1.85811169 |
111 | Brushfield spots (HP:0001088) | 1.85798292 |
112 | Abnormality of the ileum (HP:0001549) | 1.85298050 |
113 | Abnormality of placental membranes (HP:0011409) | 1.84490591 |
114 | Amniotic constriction ring (HP:0009775) | 1.84490591 |
115 | Abnormality of renal resorption (HP:0011038) | 1.84350914 |
116 | Hypothermia (HP:0002045) | 1.83435320 |
117 | Colon cancer (HP:0003003) | 1.81896671 |
118 | Abnormal pupillary function (HP:0007686) | 1.81327491 |
119 | Hypobetalipoproteinemia (HP:0003563) | 1.80621628 |
120 | Abnormality of DNA repair (HP:0003254) | 1.79660641 |
121 | Thrombocytosis (HP:0001894) | 1.77915703 |
122 | Abnormality of the anterior horn cell (HP:0006802) | 1.77521288 |
123 | Degeneration of anterior horn cells (HP:0002398) | 1.77521288 |
124 | Pheochromocytoma (HP:0002666) | 1.75185117 |
125 | Hyperinsulinemic hypoglycemia (HP:0000825) | 1.74162451 |
126 | Generalized aminoaciduria (HP:0002909) | 1.73946937 |
127 | Abnormality of the metopic suture (HP:0005556) | 1.73732061 |
128 | Neoplasm of the adrenal cortex (HP:0100641) | 1.73657955 |
129 | Neuroendocrine neoplasm (HP:0100634) | 1.73299074 |
130 | Esophageal neoplasm (HP:0100751) | 1.72738105 |
131 | Neoplasm of head and neck (HP:0012288) | 1.72738105 |
132 | Postnatal microcephaly (HP:0005484) | 1.69312700 |
133 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.66768711 |
134 | Megaloblastic anemia (HP:0001889) | 1.66497535 |
135 | Secondary amenorrhea (HP:0000869) | 1.64028720 |
136 | Neoplasm of the peripheral nervous system (HP:0100007) | 1.60864538 |
Rank | Gene Set | Z-score |
---|---|---|
1 | VRK2 | 5.19877847 |
2 | STK16 | 4.13367976 |
3 | BUB1 | 4.04447053 |
4 | NME2 | 3.86550633 |
5 | BCKDK | 3.32625619 |
6 | MAP3K12 | 3.19083037 |
7 | WEE1 | 3.13619980 |
8 | EIF2AK1 | 2.69306015 |
9 | NME1 | 2.66023264 |
10 | ZAK | 2.55284457 |
11 | PDK4 | 2.54626238 |
12 | PDK3 | 2.54626238 |
13 | FLT3 | 2.54605946 |
14 | BMPR1B | 2.43730754 |
15 | MAP4K2 | 2.05826306 |
16 | TRIM28 | 2.03911254 |
17 | VRK1 | 1.95595800 |
18 | CASK | 1.87064993 |
19 | TTK | 1.81647084 |
20 | CCNB1 | 1.80077906 |
21 | PBK | 1.79116344 |
22 | MYLK | 1.78265077 |
23 | TSSK6 | 1.75237351 |
24 | PIM2 | 1.69644353 |
25 | CDK19 | 1.58748752 |
26 | MAP2K7 | 1.58600184 |
27 | TESK2 | 1.57115633 |
28 | EIF2AK3 | 1.54426677 |
29 | BRSK2 | 1.52528288 |
30 | ATR | 1.50559220 |
31 | NUAK1 | 1.41876389 |
32 | SRPK1 | 1.41179012 |
33 | MAPKAPK5 | 1.40146155 |
34 | MAP3K11 | 1.38564017 |
35 | PNCK | 1.38485738 |
36 | MST4 | 1.38461393 |
37 | TLK1 | 1.37515718 |
38 | MUSK | 1.37224942 |
39 | NEK1 | 1.32982093 |
40 | ADRBK2 | 1.15969513 |
41 | TAF1 | 1.15928595 |
42 | PDK2 | 1.11953893 |
43 | GRK7 | 1.11618591 |
44 | OBSCN | 1.07884865 |
45 | KIT | 1.07471229 |
46 | CHEK2 | 1.07339622 |
47 | TNIK | 1.05851034 |
48 | DAPK1 | 1.05668212 |
49 | AURKA | 1.01135570 |
50 | ILK | 1.00484699 |
51 | TAOK2 | 0.99671486 |
52 | MAP3K4 | 0.97854943 |
53 | BRSK1 | 0.97520537 |
54 | LIMK1 | 0.96998678 |
55 | CDK8 | 0.96162582 |
56 | TESK1 | 0.95763161 |
57 | MAPK13 | 0.95565935 |
58 | MAP2K4 | 0.95086457 |
59 | TGFBR1 | 0.92206868 |
60 | SMG1 | 0.90575564 |
61 | RPS6KB2 | 0.88557850 |
62 | MKNK1 | 0.86639687 |
63 | GRK6 | 0.83343256 |
64 | CSNK1G3 | 0.79953346 |
65 | UHMK1 | 0.76654867 |
66 | PKN2 | 0.75363432 |
67 | CHEK1 | 0.74858379 |
68 | CDC7 | 0.74687755 |
69 | FES | 0.74316976 |
70 | BTK | 0.74072958 |
71 | CSNK2A2 | 0.72013806 |
72 | LRRK2 | 0.70663665 |
73 | TIE1 | 0.69443215 |
74 | PHKG1 | 0.68567760 |
75 | PHKG2 | 0.68567760 |
76 | ATM | 0.68335296 |
77 | CSNK1A1L | 0.68283465 |
78 | EEF2K | 0.66613934 |
79 | CAMK1 | 0.66231563 |
80 | SYK | 0.65708970 |
81 | CDK9 | 0.63677368 |
82 | DYRK3 | 0.62883490 |
83 | CSNK2A1 | 0.62611075 |
84 | TEC | 0.62300402 |
85 | MAPKAPK3 | 0.61247471 |
86 | PRKCI | 0.60236317 |
87 | MAPK4 | 0.58847948 |
88 | MAP3K6 | 0.58595720 |
89 | MAP2K6 | 0.58534219 |
90 | SCYL2 | 0.58189445 |
91 | RAF1 | 0.57898885 |
92 | MKNK2 | 0.57617980 |
93 | EIF2AK2 | 0.57285216 |
94 | PLK1 | 0.56782873 |
95 | ZAP70 | 0.55719267 |
96 | AKT2 | 0.55679183 |
97 | LMTK2 | 0.55646018 |
98 | RPS6KA5 | 0.54648154 |
99 | ADRBK1 | 0.54210893 |
100 | MAP3K8 | 0.52550325 |
101 | MAP4K1 | 0.51770091 |
102 | DAPK3 | 0.49979449 |
103 | MAP2K3 | 0.49570875 |
104 | MINK1 | 0.49358792 |
105 | PLK3 | 0.49113906 |
106 | RPS6KA4 | 0.48143444 |
107 | CSNK1G2 | 0.47413125 |
108 | KDR | 0.47254839 |
109 | CDK4 | 0.47037716 |
110 | ABL2 | 0.46522455 |
111 | PASK | 0.45648817 |
112 | PIK3CG | 0.45395147 |
113 | PLK4 | 0.44959839 |
114 | AURKB | 0.44558697 |
115 | GRK5 | 0.44068639 |
116 | PRKD3 | 0.43787986 |
117 | MAP3K5 | 0.43517837 |
118 | MATK | 0.41806024 |
119 | ARAF | 0.40269656 |
120 | STK4 | 0.38361981 |
121 | CAMK2B | 0.38173196 |
122 | CDK2 | 0.38022803 |
123 | MAPK12 | 0.37601061 |
124 | ACVR1B | 0.37071732 |
125 | NTRK3 | 0.36386372 |
126 | CSNK1G1 | 0.36191529 |
127 | PAK1 | 0.35788206 |
128 | DYRK2 | 0.35305271 |
129 | CDK1 | 0.35271089 |
130 | CDK7 | 0.34288657 |
131 | CAMKK2 | 0.33606966 |
132 | CSNK1E | 0.32787094 |
133 | PINK1 | 0.31015815 |
134 | CAMK2D | 0.30826458 |
135 | CAMK2A | 0.30509385 |
136 | PRKCG | 0.30295088 |
137 | PRKDC | 0.29880168 |
138 | BRAF | 0.29473443 |
139 | STK39 | 0.28316321 |
140 | ALK | 0.26463031 |
141 | CDK11A | 0.25719292 |
142 | ERBB3 | 0.25647788 |
143 | CDK18 | 0.23383901 |
144 | CDK14 | 0.23354501 |
145 | CDK15 | 0.23280105 |
146 | CSNK1A1 | 0.23058060 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Ribosome_Homo sapiens_hsa03010 | 4.70470899 |
2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 4.11817619 |
3 | Parkinsons disease_Homo sapiens_hsa05012 | 3.87532785 |
4 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 3.43181360 |
5 | Proteasome_Homo sapiens_hsa03050 | 3.26954059 |
6 | RNA polymerase_Homo sapiens_hsa03020 | 2.66534947 |
7 | Alzheimers disease_Homo sapiens_hsa05010 | 2.63300605 |
8 | Huntingtons disease_Homo sapiens_hsa05016 | 2.56847540 |
9 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 2.41193092 |
10 | DNA replication_Homo sapiens_hsa03030 | 2.39659090 |
11 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.22311133 |
12 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 2.19689211 |
13 | Mismatch repair_Homo sapiens_hsa03430 | 2.08117175 |
14 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.99789754 |
15 | Protein export_Homo sapiens_hsa03060 | 1.99082653 |
16 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.97526195 |
17 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.93522225 |
18 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.82033481 |
19 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.77268075 |
20 | Base excision repair_Homo sapiens_hsa03410 | 1.66763736 |
21 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.63786598 |
22 | Carbon metabolism_Homo sapiens_hsa01200 | 1.62525530 |
23 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.60010579 |
24 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.54214897 |
25 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.53774480 |
26 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.51904075 |
27 | Homologous recombination_Homo sapiens_hsa03440 | 1.50284463 |
28 | Spliceosome_Homo sapiens_hsa03040 | 1.46485707 |
29 | Sulfur relay system_Homo sapiens_hsa04122 | 1.44647369 |
30 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.44220857 |
31 | Fatty acid degradation_Homo sapiens_hsa00071 | 1.41282276 |
32 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.34862792 |
33 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.28289542 |
34 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.27911530 |
35 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.26503225 |
36 | Purine metabolism_Homo sapiens_hsa00230 | 1.24627621 |
37 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.21571912 |
38 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.19648757 |
39 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.17582073 |
40 | RNA transport_Homo sapiens_hsa03013 | 1.14539369 |
41 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.11347758 |
42 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.09067163 |
43 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.98532880 |
44 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.96216649 |
45 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.95368493 |
46 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.92377935 |
47 | Metabolic pathways_Homo sapiens_hsa01100 | 0.92360349 |
48 | Peroxisome_Homo sapiens_hsa04146 | 0.91501231 |
49 | Basal transcription factors_Homo sapiens_hsa03022 | 0.90826695 |
50 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.88368268 |
51 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.86206413 |
52 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.85775278 |
53 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.85528606 |
54 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.82391593 |
55 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.75472624 |
56 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.74175079 |
57 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.73823894 |
58 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.72796821 |
59 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.68454867 |
60 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.66833360 |
61 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.66556992 |
62 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.61545024 |
63 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.60274345 |
64 | RNA degradation_Homo sapiens_hsa03018 | 0.60149834 |
65 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.56104058 |
66 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.55995238 |
67 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.55611288 |
68 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.53843049 |
69 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.51029748 |
70 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.50257532 |
71 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.48234094 |
72 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.46312739 |
73 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.45277377 |
74 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.43462103 |
75 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.40352753 |
76 | Cell cycle_Homo sapiens_hsa04110 | 0.40062595 |
77 | Nicotine addiction_Homo sapiens_hsa05033 | 0.40047708 |
78 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.39343224 |
79 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.39299496 |
80 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.38664305 |
81 | Galactose metabolism_Homo sapiens_hsa00052 | 0.37545747 |
82 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.35456275 |
83 | Phototransduction_Homo sapiens_hsa04744 | 0.31719886 |
84 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.30902865 |
85 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.30350712 |
86 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.29635804 |
87 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.29614399 |
88 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.29006146 |
89 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.27417858 |
90 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.25203896 |
91 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.25113292 |
92 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.24493580 |
93 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.23567140 |
94 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.23510796 |
95 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.23213680 |
96 | Histidine metabolism_Homo sapiens_hsa00340 | 0.21903364 |
97 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.20961493 |
98 | Lysine degradation_Homo sapiens_hsa00310 | 0.18221204 |
99 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.18153102 |
100 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.17608125 |
101 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.16627047 |
102 | Taste transduction_Homo sapiens_hsa04742 | 0.16338832 |
103 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.16079782 |
104 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.14695539 |
105 | Retinol metabolism_Homo sapiens_hsa00830 | 0.13659595 |
106 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.13238217 |
107 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.12451426 |
108 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.12133946 |
109 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.09618999 |
110 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.09384694 |
111 | GABAergic synapse_Homo sapiens_hsa04727 | 0.08713597 |
112 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.07753927 |
113 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.07743235 |