BDH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the short-chain dehydrogenase/reductase gene family. The encoded protein forms a homotetrameric lipid-requiring enzyme of the mitochondrial membrane and has a specific requirement for phosphatidylcholine for optimal enzymatic activity. The encoded protein catalyzes the interconversion of acetoacetate and (R)-3-hydroxybutyrate, the two major ketone bodies produced during fatty acid catabolism. Alternatively spliced transcript variants encoding the same protein have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)8.30594817
2L-phenylalanine catabolic process (GO:0006559)7.01451879
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.01451879
4epoxygenase P450 pathway (GO:0019373)6.85550334
5L-phenylalanine metabolic process (GO:0006558)6.77301536
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.77301536
7aromatic amino acid family catabolic process (GO:0009074)6.41234285
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.08738875
9kynurenine metabolic process (GO:0070189)5.99976746
10indole-containing compound catabolic process (GO:0042436)5.86138015
11indolalkylamine catabolic process (GO:0046218)5.86138015
12tryptophan catabolic process (GO:0006569)5.86138015
13glyoxylate metabolic process (GO:0046487)5.85902312
14omega-hydroxylase P450 pathway (GO:0097267)5.79383412
15ethanol metabolic process (GO:0006067)5.52573058
16alpha-linolenic acid metabolic process (GO:0036109)5.50088685
17tryptophan metabolic process (GO:0006568)5.48112361
18drug metabolic process (GO:0017144)5.44738165
19bile acid biosynthetic process (GO:0006699)5.40828275
20oxidative demethylation (GO:0070989)5.34776283
21cysteine metabolic process (GO:0006534)5.33332325
22lysine catabolic process (GO:0006554)5.25980143
23lysine metabolic process (GO:0006553)5.25980143
24sulfur amino acid catabolic process (GO:0000098)5.19819252
25high-density lipoprotein particle remodeling (GO:0034375)5.13880022
26* cellular ketone body metabolic process (GO:0046950)5.05092733
27negative regulation of fibrinolysis (GO:0051918)5.02518585
28urea metabolic process (GO:0019627)4.99255350
29urea cycle (GO:0000050)4.99255350
30serine family amino acid catabolic process (GO:0009071)4.90953858
31fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.82872528
32regulation of fibrinolysis (GO:0051917)4.81001368
33bile acid metabolic process (GO:0008206)4.68936641
34protein carboxylation (GO:0018214)4.68717359
35peptidyl-glutamic acid carboxylation (GO:0017187)4.68717359
36regulation of cholesterol esterification (GO:0010872)4.67966600
37aromatic amino acid family metabolic process (GO:0009072)4.67076116
38amino-acid betaine metabolic process (GO:0006577)4.64170817
39nitrogen cycle metabolic process (GO:0071941)4.62503901
40regulation of triglyceride catabolic process (GO:0010896)4.60172999
41homocysteine metabolic process (GO:0050667)4.56843829
42reverse cholesterol transport (GO:0043691)4.52766956
43regulation of protein activation cascade (GO:2000257)4.51457340
44alpha-amino acid catabolic process (GO:1901606)4.51097427
45complement activation, alternative pathway (GO:0006957)4.48060868
46negative regulation of cholesterol transport (GO:0032375)4.46599952
47negative regulation of sterol transport (GO:0032372)4.46599952
48protein-lipid complex remodeling (GO:0034368)4.42745904
49macromolecular complex remodeling (GO:0034367)4.42745904
50plasma lipoprotein particle remodeling (GO:0034369)4.42745904
51glutamate metabolic process (GO:0006536)4.39074247
52tyrosine metabolic process (GO:0006570)4.35540866
53* ketone body metabolic process (GO:1902224)4.29743981
54acylglycerol homeostasis (GO:0055090)4.29428009
55triglyceride homeostasis (GO:0070328)4.29428009
56phospholipid efflux (GO:0033700)4.27388347
57phenylpropanoid metabolic process (GO:0009698)4.24268151
58cellular amino acid catabolic process (GO:0009063)4.24160419
59short-chain fatty acid metabolic process (GO:0046459)4.24023342
60S-adenosylmethionine metabolic process (GO:0046500)4.23327444
61alkaloid metabolic process (GO:0009820)4.21906183
62regulation of complement activation (GO:0030449)4.17795571
63coenzyme catabolic process (GO:0009109)4.16349881
64acetyl-CoA metabolic process (GO:0006084)4.12865591
65aspartate family amino acid catabolic process (GO:0009068)4.12706343
66indolalkylamine metabolic process (GO:0006586)4.10695472
67dicarboxylic acid biosynthetic process (GO:0043650)4.09213441
68cellular modified amino acid catabolic process (GO:0042219)4.09159314
69plasma lipoprotein particle clearance (GO:0034381)4.06632982
70ethanol oxidation (GO:0006069)4.01465506
71bile acid and bile salt transport (GO:0015721)4.01442802
72cellular biogenic amine catabolic process (GO:0042402)4.00682229
73amine catabolic process (GO:0009310)4.00682229
74serine family amino acid metabolic process (GO:0009069)3.99994534
75drug catabolic process (GO:0042737)3.99447998
76glycine metabolic process (GO:0006544)3.97891452
77benzene-containing compound metabolic process (GO:0042537)3.97313842
78cellular glucuronidation (GO:0052695)3.96237133
792-oxoglutarate metabolic process (GO:0006103)3.94771056
80cholesterol efflux (GO:0033344)3.90237241
81primary alcohol catabolic process (GO:0034310)3.81755561
82serine family amino acid biosynthetic process (GO:0009070)3.80463597
83carboxylic acid catabolic process (GO:0046395)3.79681534
84organic acid catabolic process (GO:0016054)3.79681534
85fatty acid beta-oxidation (GO:0006635)3.76353156
86phospholipid homeostasis (GO:0055091)3.74392807
87arginine metabolic process (GO:0006525)3.74126463
88plasma lipoprotein particle assembly (GO:0034377)3.68801621
89fatty acid oxidation (GO:0019395)3.67993427
90monocarboxylic acid catabolic process (GO:0072329)3.66510251
91imidazole-containing compound metabolic process (GO:0052803)3.63133123
92drug transmembrane transport (GO:0006855)3.62432251
93lipid oxidation (GO:0034440)3.61512151
94positive regulation of triglyceride lipase activity (GO:0061365)3.59321127
95positive regulation of lipoprotein lipase activity (GO:0051006)3.59321127
96low-density lipoprotein particle remodeling (GO:0034374)3.58905341
97carnitine metabolic process (GO:0009437)3.58692222
98fatty acid catabolic process (GO:0009062)3.58641245
99positive regulation of lipid catabolic process (GO:0050996)3.58363208
100flavonoid metabolic process (GO:0009812)3.58031028
101cholesterol homeostasis (GO:0042632)3.56819271
102regulation of cholesterol homeostasis (GO:2000188)3.56774712
103aldehyde catabolic process (GO:0046185)3.56660762
104glucuronate metabolic process (GO:0019585)3.52568783
105uronic acid metabolic process (GO:0006063)3.52568783
106sterol homeostasis (GO:0055092)3.51898408
107blood coagulation, intrinsic pathway (GO:0007597)3.51676048
108urate metabolic process (GO:0046415)3.51447505
109regulation of bile acid biosynthetic process (GO:0070857)3.50715904
110fibrinolysis (GO:0042730)3.49962109
111pyrimidine nucleobase catabolic process (GO:0006208)3.49423025
112cilium or flagellum-dependent cell motility (GO:0001539)3.45084454
113xenobiotic metabolic process (GO:0006805)3.30887817
114axonemal dynein complex assembly (GO:0070286)3.25414708
115vitamin transmembrane transport (GO:0035461)3.19730154
116behavioral response to nicotine (GO:0035095)3.17406186
117fucose catabolic process (GO:0019317)3.14736057
118L-fucose metabolic process (GO:0042354)3.14736057
119L-fucose catabolic process (GO:0042355)3.14736057
120amino acid salvage (GO:0043102)3.12431449
121L-methionine salvage (GO:0071267)3.12431449
122L-methionine biosynthetic process (GO:0071265)3.12431449
123protein activation cascade (GO:0072376)3.10635123
124quinone biosynthetic process (GO:1901663)3.09608206
125epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.98907172
126primary alcohol metabolic process (GO:0034308)2.97975108
127complement activation, classical pathway (GO:0006958)2.92652924
128complement activation (GO:0006956)2.91846012
129arginine catabolic process (GO:0006527)2.90975826
130cytolysis (GO:0019835)2.89529349
131positive regulation of fatty acid transport (GO:2000193)2.89373286
132intestinal cholesterol absorption (GO:0030299)2.88412630
133sodium-independent organic anion transport (GO:0043252)2.85078229
134neurotransmitter catabolic process (GO:0042135)2.84600513
135regulation of humoral immune response (GO:0002920)2.80807266

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.69936840
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.61420910
3* LXR_22158963_ChIP-Seq_LIVER_Mouse5.97759954
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.80076597
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.06685821
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.97618279
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.34659709
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.81215304
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.26996826
10VDR_22108803_ChIP-Seq_LS180_Human2.36366074
11DROSHA_22980978_ChIP-Seq_HELA_Human2.34426726
12ZNF274_21170338_ChIP-Seq_K562_Hela2.11194887
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.08521173
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05476192
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.8813304
16TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.99213539
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.90239093
18EZH2_22144423_ChIP-Seq_EOC_Human1.87894911
19ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.81048284
20CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.80800197
21* FOXA2_19822575_ChIP-Seq_HepG2_Human1.60200481
22ERA_21632823_ChIP-Seq_H3396_Human1.52474019
23E2F1_20622854_ChIP-Seq_HELA_Human1.50179876
24REST_21632747_ChIP-Seq_MESCs_Mouse1.48338524
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46855278
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44705101
27HTT_18923047_ChIP-ChIP_STHdh_Human1.43365806
28CLOCK_20551151_ChIP-Seq_293T_Human1.42454230
29* HNF4A_19822575_ChIP-Seq_HepG2_Human1.36977819
30BCL6_27268052_Chip-Seq_Bcells_Human1.34647489
31* AR_20517297_ChIP-Seq_VCAP_Human1.32666343
32GATA3_21878914_ChIP-Seq_MCF-7_Human1.32660732
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32521315
34* P300_27268052_Chip-Seq_Bcells_Human1.32391469
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31914551
36* ER_23166858_ChIP-Seq_MCF-7_Human1.31619022
37EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.29724791
38FOXA1_25329375_ChIP-Seq_VCAP_Human1.29632006
39FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29632006
40ZNF263_19887448_ChIP-Seq_K562_Human1.29551259
41MYC_19829295_ChIP-Seq_ESCs_Human1.29410174
42EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.27201081
43* PHF8_20622854_ChIP-Seq_HELA_Human1.27107795
44NANOG_20526341_ChIP-Seq_ESCs_Human1.26602852
45* P68_20966046_ChIP-Seq_HELA_Human1.23637378
46RAC3_21632823_ChIP-Seq_H3396_Human1.23536504
47IRF1_19129219_ChIP-ChIP_H3396_Human1.22980850
48ETV2_25802403_ChIP-Seq_MESCs_Mouse1.20344255
49CTCF_20526341_ChIP-Seq_ESCs_Human1.18501602
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15781338
51BCOR_27268052_Chip-Seq_Bcells_Human1.14628405
52ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13914160
53TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12024293
54FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10881472
55SA1_27219007_Chip-Seq_Bcells_Human1.10421698
56ELF1_20517297_ChIP-Seq_JURKAT_Human1.09245664
57RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.07518047
58YY1_22570637_ChIP-Seq_MALME-3M_Human1.06913970
59SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05649667
60EZH2_27294783_Chip-Seq_ESCs_Mouse1.05434100
61NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03881838
62* FOXH1_21741376_ChIP-Seq_ESCs_Human1.03739376
63PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02342462
64* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.00177754
65FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99842362
66SMC4_20622854_ChIP-Seq_HELA_Human0.99604488
67* HOXB7_26014856_ChIP-Seq_BT474_Human0.98650790
68* REST_18959480_ChIP-ChIP_MESCs_Mouse0.98107323
69ESR2_21235772_ChIP-Seq_MCF-7_Human0.97510470
70CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95597828
71TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94938832
72ERG_20517297_ChIP-Seq_VCAP_Human0.93889736
73LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.93323542
74NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.92569429
75* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91760865
76IGF1R_20145208_ChIP-Seq_DFB_Human0.90969347
77* TP63_22573176_ChIP-Seq_HFKS_Human0.90886092
78RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90246873
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88620380
80ESR1_21235772_ChIP-Seq_MCF-7_Human0.88370728
81GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88237372
82AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88231861
83ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87556027
84* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87462259
85FOXH1_21741376_ChIP-Seq_EPCs_Human0.86902772
86NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86440767
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86438314
88* OCT4_19829295_ChIP-Seq_ESCs_Human0.83949337
89RARG_19884340_ChIP-ChIP_MEFs_Mouse0.83467950
90ERG_21242973_ChIP-ChIP_JURKAT_Human0.83019586
91LXR_22292898_ChIP-Seq_THP-1_Human0.82885864
92STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.82461142
93ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81231614
94EGR1_19032775_ChIP-ChIP_M12_Human0.80041507
95SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79134186
96* GATA4_25053715_ChIP-Seq_YYC3_Human0.77628140
97AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76607274
98ESR1_20079471_ChIP-ChIP_T-47D_Human0.76164916
99RAD21_21589869_ChIP-Seq_MESCs_Mouse0.75852356
100PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.75300628
101BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.74374258
102MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.73728700
103GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.71328248
104SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.70117973
105CDX2_20551321_ChIP-Seq_CACO-2_Human0.70024947
106E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.69571997
107PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.69168256
108CTCF_27219007_Chip-Seq_Bcells_Human0.67060119
109CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.64754849
110RARA_24833708_ChIP-Seq_LIVER_Mouse0.63898472
111NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.63570227
112NRF2_20460467_ChIP-Seq_MEFs_Mouse0.63570227
113GATA1_22025678_ChIP-Seq_K562_Human0.62019110
114SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.60913006
115KAP1_22055183_ChIP-Seq_ESCs_Mouse0.59559761
116PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.59211903
117MYC_19915707_ChIP-ChIP_AK7_Human0.58859115
118TBX20_22080862_ChIP-Seq_HEART_Mouse0.56719365
119TBX20_22328084_ChIP-Seq_HEART_Mouse0.56719365
120SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.55919616
121DNAJC2_21179169_ChIP-ChIP_NT2_Human0.55293172
122PPAR_26484153_Chip-Seq_NCI-H1993_Human0.54273772
123TAF2_19829295_ChIP-Seq_ESCs_Human0.54270912
124CEBPB_22108803_ChIP-Seq_LS180_Human0.53157150
125* RARB_24833708_ChIP-Seq_LIVER_Mouse0.52111552
126OCT4_20526341_ChIP-Seq_ESCs_Human0.52078605
127SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.51892026
128TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.51271168
129FOXA1_25552417_ChIP-Seq_VCAP_Human0.50878940
130MYC_27129775_Chip-Seq_CORNEA_Mouse0.50628953
131P53_21459846_ChIP-Seq_SAOS-2_Human0.49953441
132CBP_21632823_ChIP-Seq_H3396_Human0.49837037
133P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.49658448
134BCAT_22108803_ChIP-Seq_LS180_Human0.49594890
135CDX2_19796622_ChIP-Seq_MESCs_Mouse0.49447735
136TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.48852828
137EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.47882396
138* GATA1_19941826_ChIP-Seq_K562_Human0.47527904
139* ESET_19884257_ChIP-Seq_ESCs_Mouse0.47354660
140STAT3_1855785_ChIP-Seq_MESCs_Mouse0.47322270
141TAF15_26573619_Chip-Seq_HEK293_Human0.46889675
142* SMAD4_21741376_ChIP-Seq_HESCs_Human0.46824270
143SALL4_18804426_ChIP-ChIP_XEN_Mouse0.46341537
144* GATA2_19941826_ChIP-Seq_K562_Human0.46244104
145NCOR_22424771_ChIP-Seq_293T_Human0.46124069
146* GATA1_19941827_ChIP-Seq_MEL_Mouse0.44890799
147RACK7_27058665_Chip-Seq_MCF-7_Human0.44714689
148* FOXO3_23340844_ChIP-Seq_DLD1_Human0.43610030
149GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.43567745
150* CREB1_26743006_Chip-Seq_LNCaP_Human0.43532249
151FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.43463238
152IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.42894392
153STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.42753112
154PIAS1_25552417_ChIP-Seq_VCAP_Human0.42462543
155TET1_21451524_ChIP-Seq_MESCs_Mouse0.42384724
156SOX2_21211035_ChIP-Seq_LN229_Human0.42106717

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.95165381
2MP0005360_urolithiasis7.64775963
3MP0005085_abnormal_gallbladder_physiolo6.10400770
4MP0005365_abnormal_bile_salt5.76285421
5MP0008875_abnormal_xenobiotic_pharmacok5.00189451
6MP0003806_abnormal_nucleotide_metabolis4.19910794
7MP0003252_abnormal_bile_duct3.67434337
8MP0010329_abnormal_lipoprotein_level3.37094591
9MP0009840_abnormal_foam_cell3.17489178
10MP0005332_abnormal_amino_acid2.98565946
11MP0003195_calcinosis2.92411698
12MP0005083_abnormal_biliary_tract2.82851961
13MP0001666_abnormal_nutrient_absorption2.55588089
14MP0003191_abnormal_cellular_cholesterol2.25003528
15MP0004019_abnormal_vitamin_homeostasis2.24427617
16MP0002118_abnormal_lipid_homeostasis2.10365545
17MP0000609_abnormal_liver_physiology1.98066646
18MP0002138_abnormal_hepatobiliary_system1.78549812
19MP0005319_abnormal_enzyme/_coenzyme1.78165239
20MP0003868_abnormal_feces_composition1.73302885
21MP0002837_dystrophic_cardiac_calcinosis1.70372594
22MP0005584_abnormal_enzyme/coenzyme_acti1.65889794
23MP0005451_abnormal_body_composition1.61623257
24MP0009745_abnormal_behavioral_response1.52072308
25MP0001968_abnormal_touch/_nociception1.45659021
26MP0001764_abnormal_homeostasis1.43963396
27MP0005645_abnormal_hypothalamus_physiol1.43011908
28MP0009643_abnormal_urine_homeostasis1.40781568
29MP0005551_abnormal_eye_electrophysiolog1.39391252
30MP0001485_abnormal_pinna_reflex1.33177627
31MP0003879_abnormal_hair_cell1.28770906
32MP0002653_abnormal_ependyma_morphology1.26856245
33MP0005646_abnormal_pituitary_gland1.26144100
34MP0000604_amyloidosis1.24631244
35MP0001986_abnormal_taste_sensitivity1.24322326
36MP0003656_abnormal_erythrocyte_physiolo1.21837053
37MP0003011_delayed_dark_adaptation1.21097611
38MP0001501_abnormal_sleep_pattern1.20422180
39MP0003329_amyloid_beta_deposits1.17858795
40MP0004130_abnormal_muscle_cell1.17610903
41MP0006036_abnormal_mitochondrial_physio1.17575251
42MP0002064_seizures1.17417194
43MP0009697_abnormal_copulation1.13588826
44MP0000566_synostosis1.13520007
45MP0005636_abnormal_mineral_homeostasis1.08102441
46MP0002822_catalepsy1.06929914
47MP0002272_abnormal_nervous_system1.06537871
48MP0003186_abnormal_redox_activity1.06500912
49MP0004885_abnormal_endolymph1.06440861
50MP0009046_muscle_twitch1.04564766
51MP0002132_abnormal_respiratory_system1.04164775
52MP0004742_abnormal_vestibular_system1.03906919
53MP0003646_muscle_fatigue0.97176950
54MP0004043_abnormal_pH_regulation0.97131174
55MP0000598_abnormal_liver_morphology0.96727375
56MP0002736_abnormal_nociception_after0.94521294
57MP0003866_abnormal_defecation0.91631136
58MP0004142_abnormal_muscle_tone0.91014513
59MP0003705_abnormal_hypodermis_morpholog0.90812539
60MP0005647_abnormal_sex_gland0.90530395
61MP0006035_abnormal_mitochondrial_morpho0.89822913
62MP0002735_abnormal_chemical_nociception0.88804443
63MP0001905_abnormal_dopamine_level0.86490134
64MP0001873_stomach_inflammation0.85517984
65MP0002572_abnormal_emotion/affect_behav0.85320087
66MP0002078_abnormal_glucose_homeostasis0.84893677
67MP0001486_abnormal_startle_reflex0.83838042
68MP0009642_abnormal_blood_homeostasis0.83711032
69MP0005377_hearing/vestibular/ear_phenot0.83693625
70MP0003878_abnormal_ear_physiology0.83693625
71MP0005535_abnormal_body_temperature0.82672217
72MP0001756_abnormal_urination0.81311130
73MP0004924_abnormal_behavior0.81144601
74MP0005386_behavior/neurological_phenoty0.81144601
75MP0003690_abnormal_glial_cell0.80884125
76MP0001664_abnormal_digestion0.80022225
77MP0002876_abnormal_thyroid_physiology0.78326584
78MP0005266_abnormal_metabolism0.77988825
79MP0005330_cardiomyopathy0.77046263
80MP0000427_abnormal_hair_cycle0.76942744
81MP0009763_increased_sensitivity_to0.76724245
82MP0009764_decreased_sensitivity_to0.76349945
83MP0005670_abnormal_white_adipose0.74991089
84MP0005376_homeostasis/metabolism_phenot0.74075101
85MP0002254_reproductive_system_inflammat0.71972261
86MP0002971_abnormal_brown_adipose0.70845698
87MP0008877_abnormal_DNA_methylation0.70558890
88MP0003183_abnormal_peptide_metabolism0.70507156
89MP0003880_abnormal_central_pattern0.70443863
90MP0002063_abnormal_learning/memory/cond0.69831517
91MP0003635_abnormal_synaptic_transmissio0.67281367
92MP0001661_extended_life_span0.66570748
93MP0010368_abnormal_lymphatic_system0.65243150
94MP0008469_abnormal_protein_level0.64634763
95MP0005666_abnormal_adipose_tissue0.64127821
96MP0000383_abnormal_hair_follicle0.63952541
97MP0005334_abnormal_fat_pad0.63938884
98MP0002557_abnormal_social/conspecific_i0.62900554
99MP0001970_abnormal_pain_threshold0.62277118
100MP0002733_abnormal_thermal_nociception0.62224820
101MP0005423_abnormal_somatic_nervous0.61888948
102MP0005084_abnormal_gallbladder_morpholo0.61833389
103MP0002229_neurodegeneration0.61792822
104MP0009379_abnormal_foot_pigmentation0.61642328
105MP0001502_abnormal_circadian_rhythm0.60785277
106MP0003787_abnormal_imprinting0.60530260
107MP0004133_heterotaxia0.59180568
108MP0002067_abnormal_sensory_capabilities0.58589636
109MP0005448_abnormal_energy_balance0.58117121
110MP0002909_abnormal_adrenal_gland0.57994385
111MP0002734_abnormal_mechanical_nocicepti0.57912460
112MP0001944_abnormal_pancreas_morphology0.57564600
113MP0008961_abnormal_basal_metabolism0.57387739
114MP0009765_abnormal_xenobiotic_induced0.56756478
115MP0001663_abnormal_digestive_system0.56506014
116MP0000230_abnormal_systemic_arterial0.55094734
117MP0002269_muscular_atrophy0.53831337
118MP0005408_hypopigmentation0.52833041
119MP0008874_decreased_physiological_sensi0.52792835
120MP0002136_abnormal_kidney_physiology0.52009979
121MP0003718_maternal_effect0.49558060
122MP0001765_abnormal_ion_homeostasis0.48255657
123MP0004215_abnormal_myocardial_fiber0.48065905
124MP0003953_abnormal_hormone_level0.47525744
125MP0000751_myopathy0.47247606
126MP0005395_other_phenotype0.46720967
127MP0008872_abnormal_physiological_respon0.44900207
128MP0005220_abnormal_exocrine_pancreas0.44161045
129MP0000639_abnormal_adrenal_gland0.43993817
130MP0004036_abnormal_muscle_relaxation0.42930153
131MP0003638_abnormal_response/metabolism_0.42627177
132MP0005166_decreased_susceptibility_to0.40822754
133MP0000579_abnormal_nail_morphology0.39243514
134MP0003075_altered_response_to0.38920902
135MP0005187_abnormal_penis_morphology0.38477200
136MP0003137_abnormal_impulse_conducting0.38267346
137MP0009053_abnormal_anal_canal0.37623942
138MP0008873_increased_physiological_sensi0.37539892
139MP0002796_impaired_skin_barrier0.37352256
140MP0003221_abnormal_cardiomyocyte_apopto0.34993828
141MP0004147_increased_porphyrin_level0.34628423
142MP0004185_abnormal_adipocyte_glucose0.33081107
143MP0000747_muscle_weakness0.32958364
144MP0001544_abnormal_cardiovascular_syste0.32683629
145MP0005385_cardiovascular_system_phenoty0.32683629
146MP0002972_abnormal_cardiac_muscle0.32174864
147MP0005167_abnormal_blood-brain_barrier0.31789056
148MP0004087_abnormal_muscle_fiber0.30777419
149MP0005248_abnormal_Harderian_gland0.30493481
150MP0002928_abnormal_bile_duct0.28943315
151MP0002069_abnormal_eating/drinking_beha0.28769652
152MP0002090_abnormal_vision0.28580218

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.62745657
2Deep venous thrombosis (HP:0002625)6.61561981
3Intrahepatic cholestasis (HP:0001406)6.47382251
4Xanthomatosis (HP:0000991)5.77373692
5Hypobetalipoproteinemia (HP:0003563)5.65512448
6Abnormality of monocarboxylic acid metabolism (HP:0010996)5.64076516
7Prolonged partial thromboplastin time (HP:0003645)5.51605173
8Hyperlipoproteinemia (HP:0010980)5.12411341
9Hyperammonemia (HP:0001987)4.71048451
10Ketosis (HP:0001946)4.69992098
11Hyperglycinemia (HP:0002154)4.47568639
12Hyperglycinuria (HP:0003108)4.44233705
13Hypolipoproteinemia (HP:0010981)4.43410114
14Abnormality of serine family amino acid metabolism (HP:0010894)4.31975693
15Abnormality of glycine metabolism (HP:0010895)4.31975693
16Complement deficiency (HP:0004431)4.24881165
17Abnormality of glutamine family amino acid metabolism (HP:0010902)4.10584159
18Hypoalphalipoproteinemia (HP:0003233)4.04241745
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.00958480
20Joint hemorrhage (HP:0005261)3.98318683
21Epidermoid cyst (HP:0200040)3.97640405
22Hypoglycemic coma (HP:0001325)3.96117207
23Abnormality of aspartate family amino acid metabolism (HP:0010899)3.93692535
24Abnormality of sulfur amino acid metabolism (HP:0004339)3.91138511
25Ketoacidosis (HP:0001993)3.88834801
26Abnormality of fatty-acid metabolism (HP:0004359)3.85221366
27Abnormality of methionine metabolism (HP:0010901)3.68185532
28Dynein arm defect of respiratory motile cilia (HP:0012255)3.62351197
29Absent/shortened dynein arms (HP:0200106)3.62351197
30Abnormality of the common coagulation pathway (HP:0010990)3.60928881
31Fat malabsorption (HP:0002630)3.54744605
32Abnormal respiratory epithelium morphology (HP:0012253)3.53752496
33Abnormal respiratory motile cilium morphology (HP:0005938)3.53752496
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.35648854
35Delayed CNS myelination (HP:0002188)3.35053343
36Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.29358027
37Gout (HP:0001997)3.18142741
38Decreased circulating renin level (HP:0003351)3.16174825
39Abnormal ciliary motility (HP:0012262)3.14786457
40Conjugated hyperbilirubinemia (HP:0002908)3.12983133
41Dicarboxylic aciduria (HP:0003215)3.11605058
42Abnormality of dicarboxylic acid metabolism (HP:0010995)3.11605058
43Hypercholesterolemia (HP:0003124)3.11397294
44Abnormal respiratory motile cilium physiology (HP:0012261)3.11054533
45Hyperbilirubinemia (HP:0002904)3.08767819
46Metabolic acidosis (HP:0001942)3.08242883
47Abnormality of the intrinsic pathway (HP:0010989)3.03534250
48Cerebral edema (HP:0002181)3.03140583
49Abnormality of complement system (HP:0005339)2.98457471
50Lethargy (HP:0001254)2.98392619
51Abnormality of serum amino acid levels (HP:0003112)2.97932307
52Pancreatic cysts (HP:0001737)2.92768490
53Abnormality of purine metabolism (HP:0004352)2.91464581
54Abnormality of nucleobase metabolism (HP:0010932)2.90694643
55Abnormality of pyrimidine metabolism (HP:0004353)2.89154765
56Hepatocellular carcinoma (HP:0001402)2.67765318
57True hermaphroditism (HP:0010459)2.66754870
58Pancreatic fibrosis (HP:0100732)2.59470051
59Rhinitis (HP:0012384)2.59001514
60Congenital stationary night blindness (HP:0007642)2.57434878
61Steatorrhea (HP:0002570)2.54978398
62Bile duct proliferation (HP:0001408)2.53629127
63Abnormal biliary tract physiology (HP:0012439)2.53629127
64Spontaneous abortion (HP:0005268)2.53111534
65Skin nodule (HP:0200036)2.52473792
66Abnormal gallbladder morphology (HP:0012437)2.52019918
67Cholelithiasis (HP:0001081)2.51977812
68Hypochromic microcytic anemia (HP:0004840)2.51671456
69Hyperactive renin-angiotensin system (HP:0000841)2.48797793
70Malnutrition (HP:0004395)2.48179072
71Vomiting (HP:0002013)2.47773751
72Irritability (HP:0000737)2.44929449
73Cholecystitis (HP:0001082)2.43781474
74Abnormal gallbladder physiology (HP:0012438)2.43781474
75Abnormality of the renal cortex (HP:0011035)2.43033333
76Vascular calcification (HP:0004934)2.42023603
77Abnormality of alanine metabolism (HP:0010916)2.41506917
78Hyperalaninemia (HP:0003348)2.41506917
79Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.41506917
80Molar tooth sign on MRI (HP:0002419)2.40546520
81Abnormality of midbrain morphology (HP:0002418)2.40546520
82Cerebral palsy (HP:0100021)2.39468524
83Neonatal onset (HP:0003623)2.37829580
84Cystic liver disease (HP:0006706)2.37736211
85Abnormality of renin-angiotensin system (HP:0000847)2.36526608
86Generalized aminoaciduria (HP:0002909)2.36431120
87Chronic bronchitis (HP:0004469)2.29516092
88Increased purine levels (HP:0004368)2.29232884
89Hyperuricemia (HP:0002149)2.29232884
90Sensorimotor neuropathy (HP:0007141)2.26894645
91Hypoglycemic seizures (HP:0002173)2.26372577
92Bronchiectasis (HP:0002110)2.25416961
93Proximal tubulopathy (HP:0000114)2.23791468
94Decreased central vision (HP:0007663)2.22108757
95Myocardial infarction (HP:0001658)2.22065455
96Late onset (HP:0003584)2.20789197
97Acanthocytosis (HP:0001927)2.18959446
98Alkalosis (HP:0001948)2.16179323
99Cardiovascular calcification (HP:0011915)2.09471564
100Spastic diplegia (HP:0001264)2.08869970
101Fair hair (HP:0002286)2.07762336
102Hyperinsulinemic hypoglycemia (HP:0000825)2.07616891
103Nephronophthisis (HP:0000090)2.07182804
104Chronic hepatic failure (HP:0100626)2.06364808
105Acute encephalopathy (HP:0006846)2.05556095
106Mitral stenosis (HP:0001718)2.02954268
107Abnormality of urine glucose concentration (HP:0011016)2.01700034
108Glycosuria (HP:0003076)2.01700034
109Metabolic alkalosis (HP:0200114)2.01567446
110Abnormality of the gallbladder (HP:0005264)2.00827469
111Myoglobinuria (HP:0002913)1.98945960
112Pancreatitis (HP:0001733)1.98678567
113Systemic lupus erythematosus (HP:0002725)1.94809367
114Brushfield spots (HP:0001088)1.94728287
115Hemorrhage of the eye (HP:0011885)1.94189244
116Abnormal cartilage morphology (HP:0002763)1.93777180
117Hydroxyprolinuria (HP:0003080)1.91661301
118Abnormality of proline metabolism (HP:0010907)1.91661301
119Amyloidosis (HP:0011034)1.91306418
120Type II lissencephaly (HP:0007260)1.91240783
121Furrowed tongue (HP:0000221)1.91171494
122Rickets (HP:0002748)1.90886697
123Renal cortical cysts (HP:0000803)1.90399463
124Enlarged kidneys (HP:0000105)1.88314759
125Hyperventilation (HP:0002883)1.86936813
126Status epilepticus (HP:0002133)1.85957573
127Esophageal varix (HP:0002040)1.84736445
128Abnormality of vitamin metabolism (HP:0100508)1.84493939
129Glomerulonephritis (HP:0000099)1.82955987
130Nephritis (HP:0000123)1.82631562
131Tubular atrophy (HP:0000092)1.81987649
132Abnormality of the renal medulla (HP:0100957)1.80835088
133Poikilocytosis (HP:0004447)1.79149783
134Large for gestational age (HP:0001520)1.78775046
135Generalized hypopigmentation of hair (HP:0011358)1.78188080
136Increased serum pyruvate (HP:0003542)1.77760425
137Abnormality of glycolysis (HP:0004366)1.77760425
138Confusion (HP:0001289)1.77699743
139Hepatic necrosis (HP:0002605)1.77313213
140Inability to walk (HP:0002540)1.76924471
141Recurrent gram-negative bacterial infections (HP:0005420)1.75233687
142Hypophosphatemic rickets (HP:0004912)1.75039666
143Acute hepatic failure (HP:0006554)1.74299986
144Amelogenesis imperfecta (HP:0000705)1.70633182
145Abnormal drinking behavior (HP:0030082)1.70102065
146Polydipsia (HP:0001959)1.70102065
147Congenital hepatic fibrosis (HP:0002612)1.69754329
148Hyperaldosteronism (HP:0000859)1.69748093
149Pigmentary retinal degeneration (HP:0001146)1.69733458
150Reduced antithrombin III activity (HP:0001976)1.69573120
151Hepatocellular necrosis (HP:0001404)1.67560789

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.68841324
2FGFR43.39844791
3SIK13.32267377
4MAPK153.23943526
5ADRBK23.23556043
6TLK12.78872685
7ERN12.62123674
8MAPKAPK32.53083053
9PKN22.51791187
10ACVR1B2.44610736
11MAP2K42.30679530
12MARK12.25804322
13MST1R2.18905146
14TRIB32.04926008
15ERBB42.02926243
16GRK12.02286788
17BMPR1B1.99211139
18INSRR1.94610588
19EPHA21.91781190
20PHKG11.91542501
21PHKG21.91542501
22WNK31.85609690
23MAPK131.80518168
24LMTK21.76358630
25PIK3CA1.72826354
26PINK11.72806066
27DAPK21.72641853
28TNK21.64835783
29MAP4K21.64822678
30PDK31.64634252
31PDK41.64634252
32EPHA41.57222726
33CAMKK11.56273741
34VRK21.52563934
35SIK21.48381039
36ZAK1.46259506
37MAP3K71.39000453
38OXSR11.37659533
39MAPK111.31888720
40TAOK31.30909377
41NEK11.29223492
42WNK41.28922597
43FGFR21.26129634
44MAP4K11.25985481
45NTRK31.25842592
46ABL21.18628655
47CAMKK21.17849902
48MAPK121.17702182
49ICK1.11371257
50MAPKAPK51.11350459
51GRK61.10319485
52PAK31.07982003
53NUAK11.05280297
54EPHB11.04220680
55PRKAA21.04108364
56PRKCZ1.03039104
57TTN1.02946646
58KIT1.01553265
59MAP2K21.01496036
60STK38L1.00786634
61PRKAA10.98797251
62PKN10.98754950
63PRKCI0.98453682
64NME10.94713518
65ADRBK10.94075976
66MAP3K40.93736409
67PTK60.93014290
68OBSCN0.91097226
69PIK3CG0.91095081
70CAMK2G0.88803898
71MAPK40.88025050
72FLT30.87453258
73MYLK0.87276003
74JAK20.85480712
75PRKACG0.84837691
76FRK0.83310923
77DAPK10.82861955
78ERBB20.80198418
79MAP2K60.80011254
80LATS20.79969090
81MET0.79863830
82MUSK0.79603061
83TXK0.77951239
84KDR0.77472871
85ITK0.77286087
86PDK20.76194222
87PDPK10.74575947
88KSR20.72902810
89STK390.68856007
90PAK60.66960236
91CAMK10.65551933
92LATS10.65178679
93SGK4940.64847687
94SGK2230.64847687
95RET0.64052623
96RIPK10.63836042
97PRKD30.62993482
98PRKCG0.60805606
99CASK0.60763475
100IKBKE0.59906634
101SGK30.59771955
102SYK0.59353471
103RPS6KB20.58545669
104IRAK10.58470695
105STK380.57798510
106IKBKB0.57504517
107VRK10.57492444
108TAOK10.56542060
109PRKCH0.55108243
110GSK3A0.53814140
111CSNK1A10.53751098
112MAP3K110.53699992
113CSNK1G20.53584163
114CHUK0.53539754
115TYK20.53179583
116PDK10.52794222
117PRKCA0.52625106
118CAMK2D0.52619544
119TSSK60.52453634
120EPHB20.51399885
121TIE10.50375846
122EPHA30.49821606
123CSF1R0.48901635
124PRKD10.48419853
125CAMK2A0.48077825
126DYRK20.46735341
127NTRK20.46189441
128PRKCQ0.45892657
129CAMK40.44555283
130CSK0.44300294
131CAMK1D0.43995268
132MAP3K60.43900931
133PRKCE0.42190559
134MINK10.42128401
135MAP3K50.41377463
136NEK90.40739573
137TYRO30.40473620
138DYRK1B0.40018125
139MAP2K10.39168063
140CSNK1G10.39084893
141CAMK1G0.39047265
142RPS6KA50.38993614
143SGK20.38887495
144STK110.38823510
145MAP3K100.38347639
146TEC0.37859632
147MAPK70.37798623
148GRK50.37232813
149NTRK10.37179852
150PRKACA0.36869906
151MAP3K90.36769606
152TBK10.36445355
153TAF10.36380334
154TESK20.36330304
155SGK10.33613513
156TGFBR10.32142457

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.94112386
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.37825540
3Nitrogen metabolism_Homo sapiens_hsa009103.33571744
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.14169042
5Arginine biosynthesis_Homo sapiens_hsa002202.88925851
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.84493560
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.79384484
8Fatty acid degradation_Homo sapiens_hsa000712.73320240
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.72541221
10Tryptophan metabolism_Homo sapiens_hsa003802.68321146
11* Butanoate metabolism_Homo sapiens_hsa006502.51125094
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.38853893
13Propanoate metabolism_Homo sapiens_hsa006402.34548510
14Complement and coagulation cascades_Homo sapiens_hsa046102.24723893
15Fatty acid metabolism_Homo sapiens_hsa012122.10645980
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.09181904
17Peroxisome_Homo sapiens_hsa041462.08222623
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.06541743
19* Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05669184
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.92681909
21PPAR signaling pathway_Homo sapiens_hsa033201.90818778
22beta-Alanine metabolism_Homo sapiens_hsa004101.74004374
23Histidine metabolism_Homo sapiens_hsa003401.73566585
24Chemical carcinogenesis_Homo sapiens_hsa052041.72184806
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.70213476
26Sulfur metabolism_Homo sapiens_hsa009201.66779437
27Pyruvate metabolism_Homo sapiens_hsa006201.66479892
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.65240424
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.64448780
30Bile secretion_Homo sapiens_hsa049761.60461726
31Fatty acid elongation_Homo sapiens_hsa000621.53183983
32Arachidonic acid metabolism_Homo sapiens_hsa005901.49578879
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.46470200
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.44960248
35Retinol metabolism_Homo sapiens_hsa008301.44729519
36Phenylalanine metabolism_Homo sapiens_hsa003601.44011689
37Carbon metabolism_Homo sapiens_hsa012001.40081547
38Caffeine metabolism_Homo sapiens_hsa002321.36185978
39Selenocompound metabolism_Homo sapiens_hsa004501.33666214
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30176328
41Tyrosine metabolism_Homo sapiens_hsa003501.29464569
42Staphylococcus aureus infection_Homo sapiens_hsa051501.27729252
43Starch and sucrose metabolism_Homo sapiens_hsa005001.25516663
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.23887051
45Biosynthesis of amino acids_Homo sapiens_hsa012301.23782055
46Fat digestion and absorption_Homo sapiens_hsa049751.21676064
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.21497676
48Steroid biosynthesis_Homo sapiens_hsa001001.17205558
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.11476656
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10683021
51Arginine and proline metabolism_Homo sapiens_hsa003301.07720491
52Folate biosynthesis_Homo sapiens_hsa007901.06735894
53ABC transporters_Homo sapiens_hsa020101.04190927
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03740196
55Sulfur relay system_Homo sapiens_hsa041220.94857588
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87317351
57Vitamin digestion and absorption_Homo sapiens_hsa049770.85809156
58Lysine degradation_Homo sapiens_hsa003100.81664240
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80983684
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.78407356
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77876805
62Vitamin B6 metabolism_Homo sapiens_hsa007500.77296605
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72837568
64Glycerolipid metabolism_Homo sapiens_hsa005610.72573083
65Glutathione metabolism_Homo sapiens_hsa004800.66906845
66Fatty acid biosynthesis_Homo sapiens_hsa000610.65526870
67Phototransduction_Homo sapiens_hsa047440.58275908
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57902597
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57692971
70Nicotine addiction_Homo sapiens_hsa050330.55820585
71Pentose phosphate pathway_Homo sapiens_hsa000300.52303263
72* Metabolic pathways_Homo sapiens_hsa011000.49969607
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49037470
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38767933
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38706571
76Fructose and mannose metabolism_Homo sapiens_hsa000510.38619644
77Serotonergic synapse_Homo sapiens_hsa047260.37074757
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36033557
79One carbon pool by folate_Homo sapiens_hsa006700.33899724
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.31188214
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30898910
82Oxidative phosphorylation_Homo sapiens_hsa001900.30508483
83Insulin secretion_Homo sapiens_hsa049110.29232364
84Galactose metabolism_Homo sapiens_hsa000520.28613894
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.28385822
86Taste transduction_Homo sapiens_hsa047420.27963836
87Insulin resistance_Homo sapiens_hsa049310.27144086
88Prion diseases_Homo sapiens_hsa050200.22140939
89Parkinsons disease_Homo sapiens_hsa050120.21885785
90Primary immunodeficiency_Homo sapiens_hsa053400.21751391
91Linoleic acid metabolism_Homo sapiens_hsa005910.20232068
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.19209606
93Glucagon signaling pathway_Homo sapiens_hsa049220.17625306
94Salivary secretion_Homo sapiens_hsa049700.16208438
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.14876583
96Alzheimers disease_Homo sapiens_hsa050100.14584205
97Amphetamine addiction_Homo sapiens_hsa050310.13010714
98AMPK signaling pathway_Homo sapiens_hsa041520.12875314
99Glutamatergic synapse_Homo sapiens_hsa047240.12760437
100Cardiac muscle contraction_Homo sapiens_hsa042600.10093440
101Renin-angiotensin system_Homo sapiens_hsa046140.08552161
102Insulin signaling pathway_Homo sapiens_hsa049100.00210641
103GABAergic synapse_Homo sapiens_hsa04727-0.1903262
104Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1844462
105African trypanosomiasis_Homo sapiens_hsa05143-0.1776152
106Ether lipid metabolism_Homo sapiens_hsa00565-0.1655243
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1638977
108Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1441134
109Type II diabetes mellitus_Homo sapiens_hsa04930-0.1439411
110Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1415324
111Regulation of autophagy_Homo sapiens_hsa04140-0.1382008
112Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1254620
113Mineral absorption_Homo sapiens_hsa04978-0.1054579
114Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0865241
115Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0830958
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0808082
117Huntingtons disease_Homo sapiens_hsa05016-0.0751112

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