BDH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1urate metabolic process (GO:0046415)8.31016995
2drug transmembrane transport (GO:0006855)7.98764402
3aminoglycoside antibiotic metabolic process (GO:0030647)7.57740678
4drug transport (GO:0015893)6.89491665
5glyoxylate metabolic process (GO:0046487)6.84037262
6lysine catabolic process (GO:0006554)6.52554593
7lysine metabolic process (GO:0006553)6.52554593
8cysteine metabolic process (GO:0006534)6.44925036
9organic cation transport (GO:0015695)6.13134977
10tryptophan catabolic process (GO:0006569)6.04058388
11indole-containing compound catabolic process (GO:0042436)6.04058388
12indolalkylamine catabolic process (GO:0046218)6.04058388
13aromatic amino acid family catabolic process (GO:0009074)5.98274263
14ribosomal small subunit assembly (GO:0000028)5.92466869
15erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.91313789
16L-phenylalanine catabolic process (GO:0006559)5.91313789
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.82854562
18L-phenylalanine metabolic process (GO:0006558)5.82854562
19tryptophan metabolic process (GO:0006568)5.75124133
20drug catabolic process (GO:0042737)5.59255360
21phosphate ion transport (GO:0006817)5.50186771
22exogenous drug catabolic process (GO:0042738)5.45475500
23fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.42361259
24homocysteine metabolic process (GO:0050667)5.42338125
25viral transcription (GO:0019083)5.33081777
26valine metabolic process (GO:0006573)5.23334009
27translational termination (GO:0006415)5.18864324
28serine family amino acid catabolic process (GO:0009071)5.15117422
29branched-chain amino acid metabolic process (GO:0009081)5.13220759
30amino-acid betaine metabolic process (GO:0006577)5.02096085
31glucuronate metabolic process (GO:0019585)4.89578472
32uronic acid metabolic process (GO:0006063)4.89578472
33SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.84824356
34short-chain fatty acid metabolic process (GO:0046459)4.84001984
35serine family amino acid metabolic process (GO:0009069)4.83367457
36phosphate ion transmembrane transport (GO:0035435)4.83009027
37cotranslational protein targeting to membrane (GO:0006613)4.80449249
38kynurenine metabolic process (GO:0070189)4.80389181
39mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.77470468
40response to mercury ion (GO:0046689)4.74086430
41protein targeting to ER (GO:0045047)4.72401803
42tricarboxylic acid metabolic process (GO:0072350)4.69942101
43quaternary ammonium group transport (GO:0015697)4.67132458
44sulfur amino acid catabolic process (GO:0000098)4.65751977
45establishment of protein localization to endoplasmic reticulum (GO:0072599)4.52989065
46branched-chain amino acid catabolic process (GO:0009083)4.52913719
47cellular glucuronidation (GO:0052695)4.49423381
48protein localization to endoplasmic reticulum (GO:0070972)4.47603245
49carnitine metabolic process (GO:0009437)4.47346975
50serine family amino acid biosynthetic process (GO:0009070)4.46165096
51cellular modified amino acid catabolic process (GO:0042219)4.41411565
52aromatic amino acid family metabolic process (GO:0009072)4.39943280
53amine catabolic process (GO:0009310)4.39611847
54cellular biogenic amine catabolic process (GO:0042402)4.39611847
55aldehyde catabolic process (GO:0046185)4.39280671
56aspartate family amino acid catabolic process (GO:0009068)4.39092403
57benzene-containing compound metabolic process (GO:0042537)4.35959662
58excretion (GO:0007588)4.33679848
59indolalkylamine metabolic process (GO:0006586)4.31747193
602-oxoglutarate metabolic process (GO:0006103)4.29123244
61bile acid biosynthetic process (GO:0006699)4.28811130
62chaperone-mediated protein transport (GO:0072321)4.27664442
63alpha-amino acid catabolic process (GO:1901606)4.26375196
64proline metabolic process (GO:0006560)4.22348201
65energy coupled proton transport, down electrochemical gradient (GO:0015985)4.21211397
66ATP synthesis coupled proton transport (GO:0015986)4.21211397
67cellular amino acid catabolic process (GO:0009063)4.18312004
68translational elongation (GO:0006414)4.16809766
69vitamin D metabolic process (GO:0042359)4.16030540
70renal absorption (GO:0070293)4.09851343
71trivalent inorganic anion homeostasis (GO:0072506)4.03982158
72phosphate ion homeostasis (GO:0055062)4.03982158
73fructose metabolic process (GO:0006000)3.96118178
74* fatty acid beta-oxidation (GO:0006635)3.91232144
75viral life cycle (GO:0019058)3.89566744
76toxin transport (GO:1901998)3.88339963
77cellular protein complex disassembly (GO:0043624)3.88203123
78xenobiotic catabolic process (GO:0042178)3.87705937
79nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.85088741
80response to nitrosative stress (GO:0051409)3.82818231
81glutathione metabolic process (GO:0006749)3.81683780
82* fatty acid oxidation (GO:0019395)3.81104239
83* organic acid catabolic process (GO:0016054)3.80376251
84* carboxylic acid catabolic process (GO:0046395)3.80376251
85* lipid oxidation (GO:0034440)3.76311957
86protein neddylation (GO:0045116)3.76170658
87maturation of SSU-rRNA (GO:0030490)3.75889878
88establishment of protein localization to mitochondrial membrane (GO:0090151)3.75519850
89metanephric tubule development (GO:0072170)3.71453244
90metanephric nephron tubule development (GO:0072234)3.71453244
91glutathione derivative biosynthetic process (GO:1901687)3.70847000
92glutathione derivative metabolic process (GO:1901685)3.70847000
93mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.70381770
94glutamate metabolic process (GO:0006536)3.68352928
95cellular ketone body metabolic process (GO:0046950)3.67593669
96indole-containing compound metabolic process (GO:0042430)3.62749578
97flavonoid metabolic process (GO:0009812)3.56754524
98translational initiation (GO:0006413)3.55893441
99* monocarboxylic acid catabolic process (GO:0072329)3.55327722
100glutathione biosynthetic process (GO:0006750)3.55091041
101* nonribosomal peptide biosynthetic process (GO:0019184)3.55091041
102L-ascorbic acid metabolic process (GO:0019852)3.54645719
103ribosomal large subunit biogenesis (GO:0042273)3.51762266
104chromatin remodeling at centromere (GO:0031055)3.48758647
105modified amino acid transport (GO:0072337)3.47325101
106* fatty acid catabolic process (GO:0009062)3.41686834
107nicotinamide nucleotide biosynthetic process (GO:0019359)3.40587139
108pyridine nucleotide biosynthetic process (GO:0019363)3.40587139
109drug metabolic process (GO:0017144)3.39818676
110NAD biosynthetic process (GO:0009435)3.39135798
111ribosomal small subunit biogenesis (GO:0042274)3.38944647
112intraciliary transport (GO:0042073)3.36101546
113glycine metabolic process (GO:0006544)3.35963643
114biotin metabolic process (GO:0006768)3.35825869
115amino-acid betaine transport (GO:0015838)3.35587065
116carnitine transport (GO:0015879)3.35587065
117* small molecule catabolic process (GO:0044282)3.35188878
118metanephric nephron epithelium development (GO:0072243)3.34326331
119tyrosine metabolic process (GO:0006570)3.34238900
120acetyl-CoA metabolic process (GO:0006084)3.31246352
121bile acid metabolic process (GO:0008206)3.30341756
122sequestering of actin monomers (GO:0042989)3.28629175
123CENP-A containing nucleosome assembly (GO:0034080)3.26334895
124protein complex disassembly (GO:0043241)3.24506941
125respiratory electron transport chain (GO:0022904)3.24454009
126polyol transport (GO:0015791)3.24081321
127dicarboxylic acid metabolic process (GO:0043648)3.23682759
128sulfur amino acid metabolic process (GO:0000096)3.23485859
129metanephric epithelium development (GO:0072207)3.23413758
130protein targeting to membrane (GO:0006612)3.14844168
131electron transport chain (GO:0022900)3.14566971
132macromolecular complex disassembly (GO:0032984)3.10137831
133positive regulation of gastrulation (GO:2000543)2.97524306
134translation (GO:0006412)2.97340377
135establishment of integrated proviral latency (GO:0075713)2.96074823
136RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.94477636
137tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.94477636
138protein complex biogenesis (GO:0070271)2.88469021
139somite development (GO:0061053)2.87968156
140nuclear-transcribed mRNA catabolic process (GO:0000956)2.86636858
141nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.83266221
142regulation of non-canonical Wnt signaling pathway (GO:2000050)2.81186085
143platelet dense granule organization (GO:0060155)2.79301258
144epithelial cilium movement (GO:0003351)2.70890658
145cullin deneddylation (GO:0010388)2.70078794
146mitochondrial respiratory chain complex assembly (GO:0033108)2.67260394
147mRNA catabolic process (GO:0006402)2.66462878
148mitochondrial respiratory chain complex I assembly (GO:0032981)2.65856645
149NADH dehydrogenase complex assembly (GO:0010257)2.65856645
150mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.65856645
151epoxygenase P450 pathway (GO:0019373)2.65239352
152neuron fate determination (GO:0048664)2.64688654
153nonmotile primary cilium assembly (GO:0035058)2.62087729
154exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.61875979
155G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.57365612
156oxidative phosphorylation (GO:0006119)2.55605967
157L-serine metabolic process (GO:0006563)2.54766440
158respiratory chain complex IV assembly (GO:0008535)2.54221028
159limb bud formation (GO:0060174)2.53380508
160axon extension involved in axon guidance (GO:0048846)2.53055336
161neuron projection extension involved in neuron projection guidance (GO:1902284)2.53055336
162negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.52799472
163histone exchange (GO:0043486)2.52407319
164lateral sprouting from an epithelium (GO:0060601)2.50301401
165regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.49226372
166DNA integration (GO:0015074)2.48510474
167water-soluble vitamin biosynthetic process (GO:0042364)2.42100725
168response to redox state (GO:0051775)2.40866985
169DNA damage response, detection of DNA damage (GO:0042769)2.40468734
170DNA replication-independent nucleosome assembly (GO:0006336)2.39869691
171DNA replication-independent nucleosome organization (GO:0034724)2.39869691
172DNA ligation (GO:0006266)2.39697542
173ATP biosynthetic process (GO:0006754)2.38127623
174protein deneddylation (GO:0000338)2.37749956
175omega-hydroxylase P450 pathway (GO:0097267)2.36122836
176proteasome assembly (GO:0043248)2.33553068
177thalamus development (GO:0021794)2.32324405
178intracellular protein transmembrane import (GO:0044743)2.31115565
179RNA catabolic process (GO:0006401)2.30915006
180regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.30835527
181ethanol oxidation (GO:0006069)2.30813239
182epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.30657034
183establishment of viral latency (GO:0019043)2.30488838
184mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.27948328
185paraxial mesoderm development (GO:0048339)2.27719038
186quinone biosynthetic process (GO:1901663)2.27415509

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.46088922
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.54948474
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.75846342
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.29166502
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.85846398
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.68378194
7CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.66341615
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.61346078
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.60815662
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.51865239
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.39541216
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.36174812
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.22016694
14EST1_17652178_ChIP-ChIP_JURKAT_Human3.10632245
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.82794916
16CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.60295801
17ELK1_19687146_ChIP-ChIP_HELA_Human2.50998683
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.50836748
19ESR1_21235772_ChIP-Seq_MCF-7_Human2.49859722
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.49038161
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.31895112
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.31610301
23MYC_18555785_ChIP-Seq_MESCs_Mouse2.22941687
24FUS_26573619_Chip-Seq_HEK293_Human2.20691134
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.18950643
26RARG_19884340_ChIP-ChIP_MEFs_Mouse2.14464368
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.13580878
28POU5F1_16153702_ChIP-ChIP_HESCs_Human2.07827084
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.98067585
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.96059164
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.95068962
32CDX2_20551321_ChIP-Seq_CACO-2_Human1.94118790
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89696430
34TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.88758432
35EWS_26573619_Chip-Seq_HEK293_Human1.86574526
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.84495003
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.77991721
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.77728913
39JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.72723646
40EZH2_22144423_ChIP-Seq_EOC_Human1.69141949
41TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66303183
42NANOG_16153702_ChIP-ChIP_HESCs_Human1.62945624
43P300_19829295_ChIP-Seq_ESCs_Human1.62289361
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61431683
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59181760
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.58852593
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.58020473
48ZNF274_21170338_ChIP-Seq_K562_Hela1.54673061
49SOX2_16153702_ChIP-ChIP_HESCs_Human1.54312629
50MYC_18940864_ChIP-ChIP_HL60_Human1.54224291
51TRIM28_21343339_ChIP-Seq_HEK293_Human1.50125629
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49826293
53E2F1_18555785_ChIP-Seq_MESCs_Mouse1.47504256
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46382521
55E2F4_17652178_ChIP-ChIP_JURKAT_Human1.44661730
56* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.42080241
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41950631
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.40082449
59FOXP3_21729870_ChIP-Seq_TREG_Human1.39319162
60NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.37891864
61* VDR_23849224_ChIP-Seq_CD4+_Human1.37231475
62Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.34921797
63* HNF4A_19822575_ChIP-Seq_HepG2_Human1.34135896
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32562975
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32512659
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31007489
67ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29496559
68NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.27098069
69ELK1_22589737_ChIP-Seq_MCF10A_Human1.26032012
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25011705
71PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24502998
72POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23159592
73ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.21907536
74MYC_19079543_ChIP-ChIP_MESCs_Mouse1.20924278
75TTF2_22483619_ChIP-Seq_HELA_Human1.20197074
76GATA4_25053715_ChIP-Seq_YYC3_Human1.19666445
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.19416687
78* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18269562
79PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18187999
80GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18187180
81RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17489897
82KAP1_22055183_ChIP-Seq_ESCs_Mouse1.15800762
83FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.15490549
84MYC_18358816_ChIP-ChIP_MESCs_Mouse1.14077898
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13856431
86ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13517066
87NFE2_27457419_Chip-Seq_LIVER_Mouse1.12894531
88FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11847608
89AR_20517297_ChIP-Seq_VCAP_Human1.11610133
90TAF15_26573619_Chip-Seq_HEK293_Human1.11278585
91CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11211013
92HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.09759727
93IRF1_19129219_ChIP-ChIP_H3396_Human1.09483933
94CLOCK_20551151_ChIP-Seq_293T_Human1.09200565
95SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.07645575
96ESR2_21235772_ChIP-Seq_MCF-7_Human1.06396550
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05203734
98TCF3_18692474_ChIP-Seq_MEFs_Mouse1.03052845
99MYC_19030024_ChIP-ChIP_MESCs_Mouse1.01990561
100CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01820324
101TP63_19390658_ChIP-ChIP_HaCaT_Human1.01266828
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01129874
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.01063295
104FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00989543
105* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99969290
106XRN2_22483619_ChIP-Seq_HELA_Human0.99408179
107STAT1_17558387_ChIP-Seq_HELA_Human0.98405894
108UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98074482
109AR_21909140_ChIP-Seq_LNCAP_Human0.97940699
110CBX2_27304074_Chip-Seq_ESCs_Mouse0.97716436
111GBX2_23144817_ChIP-Seq_PC3_Human0.96993790
112SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.96690247
113FOXA2_19822575_ChIP-Seq_HepG2_Human0.95814105
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95773796
115NANOG_19829295_ChIP-Seq_ESCs_Human0.95351181
116SOX2_19829295_ChIP-Seq_ESCs_Human0.95351181
117TCF4_22108803_ChIP-Seq_LS180_Human0.94455016
118* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.94271302
119PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93679683
120EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93019300
121SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92785239
122NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.92712069
123NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92498168
124RXRA_24833708_ChIP-Seq_LIVER_Mouse0.91256633
125NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90702925
126NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90702925
127CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90142559
128OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89799649
129SRF_21415370_ChIP-Seq_HL-1_Mouse0.88863978
130VDR_22108803_ChIP-Seq_LS180_Human0.88327930
131KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.88240619
132KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.88240619
133KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.88240619
134TBX3_20139965_ChIP-Seq_ESCs_Mouse0.87633517
135GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.86632431
136CRX_20693478_ChIP-Seq_RETINA_Mouse0.85883728
137SOX2_22085726_ChIP-Seq_NPCs_Mouse0.85749402
138STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83183235
139FLI1_27457419_Chip-Seq_LIVER_Mouse0.82761195
140PCGF2_27294783_Chip-Seq_ESCs_Mouse0.82675454
141CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.82387792
142SOX2_20726797_ChIP-Seq_SW620_Human0.82139723
143BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79843461
144SOX2_27498859_Chip-Seq_STOMACH_Mouse0.79382208
145CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.78807777
146CDX2_19796622_ChIP-Seq_MESCs_Mouse0.78211886
147OCT4_18555785_Chip-Seq_ESCs_Mouse0.77310340
148CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.76731863
149ELF1_17652178_ChIP-ChIP_JURKAT_Human0.76650482
150PPAR_26484153_Chip-Seq_NCI-H1993_Human0.75739549
151PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.73310343
152ESRRB_18555785_Chip-Seq_ESCs_Mouse0.72375194
153ESET_19884257_ChIP-Seq_ESCs_Mouse0.71042284
154AUTS2_25519132_ChIP-Seq_293T-REX_Human0.70929564
155OCT4_21477851_ChIP-Seq_ESCs_Mouse0.70170091
156IGF1R_20145208_ChIP-Seq_DFB_Human0.69307100
157CJUN_26792858_Chip-Seq_BT549_Human0.69301326
158LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.69012697
159STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.68514399
160ZFX_18555785_Chip-Seq_ESCs_Mouse0.68328183
161BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.67645868
162* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66786260
163ERG_20517297_ChIP-Seq_VCAP_Human0.65814402
164PHF8_20622853_ChIP-Seq_HELA_Human0.64040682
165SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.63984666
166RUNX1_27457419_Chip-Seq_LIVER_Mouse0.63949083
167THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.63492773
168STAT3_18555785_Chip-Seq_ESCs_Mouse0.63236168
169FOXH1_21741376_ChIP-Seq_EPCs_Human0.63218211
170TAF2_19829295_ChIP-Seq_ESCs_Human0.63005556
171HNFA_21074721_ChIP-Seq_CACO-2_Human0.62911470
172CBP_21632823_ChIP-Seq_H3396_Human0.62557761
173TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.62167333
174LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.61073025
175PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.60835772
176ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.60575436
177SCL_19346495_ChIP-Seq_HPC-7_Human0.60533756

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.05347427
2MP0002139_abnormal_hepatobiliary_system6.24678528
3MP0008875_abnormal_xenobiotic_pharmacok4.50446878
4MP0004019_abnormal_vitamin_homeostasis4.32285788
5MP0005332_abnormal_amino_acid4.29483952
6MP0005365_abnormal_bile_salt4.14240529
7MP0005085_abnormal_gallbladder_physiolo4.07320154
8MP0009379_abnormal_foot_pigmentation3.67122346
9MP0003195_calcinosis3.62064148
10MP0004043_abnormal_pH_regulation3.60093449
11MP0006292_abnormal_olfactory_placode3.36723548
12MP0002138_abnormal_hepatobiliary_system3.27258319
13MP0003252_abnormal_bile_duct3.06599723
14MP0009643_abnormal_urine_homeostasis2.96074152
15MP0002938_white_spotting2.79500329
16MP0001293_anophthalmia2.73126338
17MP0003186_abnormal_redox_activity2.61080173
18MP0003806_abnormal_nucleotide_metabolis2.35604887
19MP0005636_abnormal_mineral_homeostasis2.34823001
20MP0001765_abnormal_ion_homeostasis2.24643213
21MP0005503_abnormal_tendon_morphology2.23928755
22MP0001958_emphysema2.23885234
23MP0002136_abnormal_kidney_physiology2.19617983
24MP0001756_abnormal_urination2.03312406
25MP0002233_abnormal_nose_morphology2.02113231
26MP0005171_absent_coat_pigmentation1.99212923
27MP0010329_abnormal_lipoprotein_level1.91849634
28MP0005377_hearing/vestibular/ear_phenot1.88506596
29MP0003878_abnormal_ear_physiology1.88506596
30MP0005451_abnormal_body_composition1.88079835
31MP0005394_taste/olfaction_phenotype1.82326093
32MP0005499_abnormal_olfactory_system1.82326093
33MP0000049_abnormal_middle_ear1.76094364
34MP0005670_abnormal_white_adipose1.70951376
35MP0003283_abnormal_digestive_organ1.59896865
36MP0005319_abnormal_enzyme/_coenzyme1.58876308
37MP0006072_abnormal_retinal_apoptosis1.58768352
38MP0001666_abnormal_nutrient_absorption1.58052372
39MP0003937_abnormal_limbs/digits/tail_de1.57573654
40MP0000372_irregular_coat_pigmentation1.56075598
41MP0002653_abnormal_ependyma_morphology1.50016320
42MP0005584_abnormal_enzyme/coenzyme_acti1.47174753
43MP0001529_abnormal_vocalization1.46770794
44MP0002234_abnormal_pharynx_morphology1.46124131
45MP0005248_abnormal_Harderian_gland1.45662263
46MP0001299_abnormal_eye_distance/1.43535137
47MP0003718_maternal_effect1.43040676
48MP0001764_abnormal_homeostasis1.42005686
49MP0001286_abnormal_eye_development1.40413059
50MP0003011_delayed_dark_adaptation1.38229893
51MP0010368_abnormal_lymphatic_system1.36430205
52MP0002928_abnormal_bile_duct1.35886798
53MP0002638_abnormal_pupillary_reflex1.35679673
54MP0003938_abnormal_ear_development1.35287249
55MP0002876_abnormal_thyroid_physiology1.34225662
56MP0006054_spinal_hemorrhage1.32819630
57MP0002697_abnormal_eye_size1.31895484
58MP0005253_abnormal_eye_physiology1.29493283
59MP0009250_abnormal_appendicular_skeleto1.28933774
60MP0008438_abnormal_cutaneous_collagen1.27508854
61MP0003880_abnormal_central_pattern1.27414733
62MP0005508_abnormal_skeleton_morphology1.24074193
63MP0003122_maternal_imprinting1.23768292
64MP0005084_abnormal_gallbladder_morpholo1.23582196
65MP0000538_abnormal_urinary_bladder1.23484040
66MP0003890_abnormal_embryonic-extraembry1.22971943
67MP0002102_abnormal_ear_morphology1.22572255
68MP0002118_abnormal_lipid_homeostasis1.22391950
69MP0001485_abnormal_pinna_reflex1.21541719
70MP0003136_yellow_coat_color1.21327654
71MP0002751_abnormal_autonomic_nervous1.19750368
72MP0005391_vision/eye_phenotype1.19676122
73MP0004272_abnormal_basement_membrane1.18104210
74MP0003567_abnormal_fetal_cardiomyocyte1.17006674
75MP0003119_abnormal_digestive_system1.16553050
76MP0009764_decreased_sensitivity_to1.15845488
77MP0008058_abnormal_DNA_repair1.15707989
78MP0005647_abnormal_sex_gland1.14149923
79MP0001324_abnormal_eye_pigmentation1.14128635
80MP0006276_abnormal_autonomic_nervous1.12884546
81MP0005275_abnormal_skin_tensile1.11233243
82MP0000609_abnormal_liver_physiology1.10101969
83MP0005083_abnormal_biliary_tract1.09508671
84MP0002092_abnormal_eye_morphology1.08051529
85MP0002135_abnormal_kidney_morphology1.07807140
86MP0003755_abnormal_palate_morphology1.06693876
87MP0008932_abnormal_embryonic_tissue1.05415707
88MP0000778_abnormal_nervous_system1.03165717
89MP0004142_abnormal_muscle_tone1.02815883
90MP0001346_abnormal_lacrimal_gland0.99319786
91MP0005257_abnormal_intraocular_pressure0.97060541
92MP0003724_increased_susceptibility_to0.95164311
93MP0000631_abnormal_neuroendocrine_gland0.95118345
94MP0009697_abnormal_copulation0.95071612
95MP0000762_abnormal_tongue_morphology0.94721715
96MP0005195_abnormal_posterior_eye0.92052958
97MP0001177_atelectasis0.90697323
98MP0005551_abnormal_eye_electrophysiolog0.89644264
99MP0002090_abnormal_vision0.89142354
100MP0002168_other_aberrant_phenotype0.89060873
101MP0003385_abnormal_body_wall0.87025906
102MP0000537_abnormal_urethra_morphology0.86922268
103MP0008469_abnormal_protein_level0.86573563
104MP0002249_abnormal_larynx_morphology0.85529993
105MP0002295_abnormal_pulmonary_circulatio0.85314891
106MP0001661_extended_life_span0.84846064
107MP0005408_hypopigmentation0.83965168
108MP0002109_abnormal_limb_morphology0.83886963
109MP0003693_abnormal_embryo_hatching0.83737625
110MP0004147_increased_porphyrin_level0.82834103
111MP0005197_abnormal_uvea_morphology0.82022589
112MP0009642_abnormal_blood_homeostasis0.81671983
113MP0002932_abnormal_joint_morphology0.81060477
114MP0000462_abnormal_digestive_system0.80543745
115MP0001853_heart_inflammation0.79601280
116MP0003191_abnormal_cellular_cholesterol0.78808211
117MP0009384_cardiac_valve_regurgitation0.78322558
118MP0010386_abnormal_urinary_bladder0.78181999
119MP0002111_abnormal_tail_morphology0.78167393
120MP0003121_genomic_imprinting0.78008527
121MP0000428_abnormal_craniofacial_morphol0.77540114
122MP0000598_abnormal_liver_morphology0.77479339
123MP0005058_abnormal_lysosome_morphology0.76970584
124MP0001984_abnormal_olfaction0.76518491
125MP0006036_abnormal_mitochondrial_physio0.73610826
126MP0005220_abnormal_exocrine_pancreas0.72811871
127MP0003638_abnormal_response/metabolism_0.70705928
128MP0000230_abnormal_systemic_arterial0.69777453
129MP0009765_abnormal_xenobiotic_induced0.69350026
130MP0000371_diluted_coat_color0.69251227
131MP0004133_heterotaxia0.67879358
132MP0002089_abnormal_postnatal_growth/wei0.65485228
133MP0005535_abnormal_body_temperature0.64603277
134MP0003942_abnormal_urinary_system0.64402920
135MP0003868_abnormal_feces_composition0.63490924
136MP0005395_other_phenotype0.62464267
137MP0008961_abnormal_basal_metabolism0.61676629
138MP0003941_abnormal_skin_development0.61304399
139MP0003172_abnormal_lysosome_physiology0.59697470
140MP0004885_abnormal_endolymph0.58872495
141MP0002282_abnormal_trachea_morphology0.57992838
142MP0004782_abnormal_surfactant_physiolog0.54477964
143MP0009763_increased_sensitivity_to0.52363269
144MP0010030_abnormal_orbit_morphology0.51182352
145MP0005666_abnormal_adipose_tissue0.51093719
146MP0009840_abnormal_foam_cell0.50676798
147MP0002115_abnormal_skeleton_extremities0.48658746
148MP0000566_synostosis0.47393081
149MP0005376_homeostasis/metabolism_phenot0.47020950
150MP0001270_distended_abdomen0.45748185
151MP0000163_abnormal_cartilage_morphology0.43299999
152MP0000026_abnormal_inner_ear0.41548073
153MP0008004_abnormal_stomach_pH0.41464354
154MP0002896_abnormal_bone_mineralization0.41112467
155MP0002098_abnormal_vibrissa_morphology0.38468670
156MP0003943_abnormal_hepatobiliary_system0.37910218
157MP0004381_abnormal_hair_follicle0.37299017
158MP0001845_abnormal_inflammatory_respons0.36684765
159MP0008789_abnormal_olfactory_epithelium0.35466307
160MP0001119_abnormal_female_reproductive0.34520940
161MP0003953_abnormal_hormone_level0.34324167
162MP0005595_abnormal_vascular_smooth0.33864270
163MP0005646_abnormal_pituitary_gland0.33701930
164MP0001663_abnormal_digestive_system0.33060557
165MP0009053_abnormal_anal_canal0.32615824
166MP0000534_abnormal_ureter_morphology0.32387241
167MP0005075_abnormal_melanosome_morpholog0.31547046
168MP0002160_abnormal_reproductive_system0.31262634
169MP0005266_abnormal_metabolism0.30342684

Predicted human phenotypes

RankGene SetZ-score
1Metabolic alkalosis (HP:0200114)5.72876055
2Hyperactive renin-angiotensin system (HP:0000841)5.55971089
3Gout (HP:0001997)5.54937203
4Increased circulating renin level (HP:0000848)5.52404167
5Hyperglycinuria (HP:0003108)5.51196902
6Hypokalemic alkalosis (HP:0001949)5.44721782
7Hypomagnesemia (HP:0002917)5.31379172
8Polyuria (HP:0000103)5.08403976
9Abnormality of glutamine family amino acid metabolism (HP:0010902)5.02441144
10Abnormality of chloride homeostasis (HP:0011422)4.87862632
11Abnormal urine output (HP:0012590)4.81749362
12Proximal tubulopathy (HP:0000114)4.75505966
13Abnormality of renal excretion (HP:0011036)4.66669907
14Abnormality of glycine metabolism (HP:0010895)4.59061639
15Abnormality of serine family amino acid metabolism (HP:0010894)4.59061639
16Abnormality of magnesium homeostasis (HP:0004921)4.45809469
17Reticulocytopenia (HP:0001896)4.32474425
18Alkalosis (HP:0001948)4.32276894
19Tetany (HP:0001281)4.18863786
20Polydipsia (HP:0001959)4.18157062
21Abnormal drinking behavior (HP:0030082)4.18157062
22Abnormality of purine metabolism (HP:0004352)4.16299016
23Hyperuricemia (HP:0002149)4.15499238
24Increased purine levels (HP:0004368)4.15499238
25Generalized aminoaciduria (HP:0002909)4.15406381
26Renal tubular acidosis (HP:0001947)3.76634936
27Abnormality of aromatic amino acid family metabolism (HP:0004338)3.75615063
28Colon cancer (HP:0003003)3.74669707
29Abnormality of renin-angiotensin system (HP:0000847)3.73507281
30Hyperaldosteronism (HP:0000859)3.72681694
31Abnormality of aspartate family amino acid metabolism (HP:0010899)3.70673848
32Ketosis (HP:0001946)3.69504667
33Renal salt wasting (HP:0000127)3.64762500
34Hyperglycinemia (HP:0002154)3.64483462
35Ketoacidosis (HP:0001993)3.64259252
36Abnormality of nucleobase metabolism (HP:0010932)3.58842319
37Acute encephalopathy (HP:0006846)3.38251948
38Macrocytic anemia (HP:0001972)3.36151037
39Septo-optic dysplasia (HP:0100842)3.35851133
40Increased hepatocellular lipid droplets (HP:0006565)3.35315937
41Intrahepatic cholestasis (HP:0001406)3.34413639
42Acute necrotizing encephalopathy (HP:0006965)3.33131738
43Glycosuria (HP:0003076)3.26567800
44Abnormality of urine glucose concentration (HP:0011016)3.26567800
45Hyperammonemia (HP:0001987)3.26262128
46Abnormality of cells of the erythroid lineage (HP:0012130)3.15188372
47Abnormality of fatty-acid metabolism (HP:0004359)3.14454351
48Delayed CNS myelination (HP:0002188)3.14443652
49Vascular calcification (HP:0004934)3.11476993
50Mitochondrial inheritance (HP:0001427)3.11094214
51Hydroxyprolinuria (HP:0003080)3.10930893
52Abnormality of proline metabolism (HP:0010907)3.10930893
53Abnormality of sulfur amino acid metabolism (HP:0004339)3.04899387
54Lipid accumulation in hepatocytes (HP:0006561)3.04286951
55Enlarged kidneys (HP:0000105)2.98190208
56Hypercalciuria (HP:0002150)2.97337480
57Abnormality of dicarboxylic acid metabolism (HP:0010995)2.95544320
58Dicarboxylic aciduria (HP:0003215)2.95544320
59Abnormal mitochondria in muscle tissue (HP:0008316)2.92630287
60Abnormal number of erythroid precursors (HP:0012131)2.91465638
61True hermaphroditism (HP:0010459)2.90637887
62Abnormality of monocarboxylic acid metabolism (HP:0010996)2.86754739
63Pancreatic fibrosis (HP:0100732)2.84951776
64Partial duplication of thumb phalanx (HP:0009944)2.82519890
65Hepatocellular necrosis (HP:0001404)2.79522724
66Cardiovascular calcification (HP:0011915)2.78540538
67Metabolic acidosis (HP:0001942)2.75409577
68Renal Fanconi syndrome (HP:0001994)2.74936751
69Molar tooth sign on MRI (HP:0002419)2.73592194
70Abnormality of midbrain morphology (HP:0002418)2.73592194
71Progressive macrocephaly (HP:0004481)2.73178000
72Abnormality of serum amino acid levels (HP:0003112)2.69160258
73Partial duplication of the phalanx of hand (HP:0009999)2.68625824
74Nephrolithiasis (HP:0000787)2.65919362
75Bifid tongue (HP:0010297)2.63762858
76Medial flaring of the eyebrow (HP:0010747)2.63317457
77Xanthomatosis (HP:0000991)2.62307582
78Abnormality of the phalanges of the 2nd finger (HP:0009541)2.61178622
79Increased CSF lactate (HP:0002490)2.60283148
80Hypokalemia (HP:0002900)2.59947354
81Rickets (HP:0002748)2.57850510
823-Methylglutaconic aciduria (HP:0003535)2.55850900
83Hepatic necrosis (HP:0002605)2.55213884
84Abnormality of the labia minora (HP:0012880)2.53920128
85Abnormal urine phosphate concentration (HP:0012599)2.50676783
86Hypophosphatemia (HP:0002148)2.50422612
87Nephrocalcinosis (HP:0000121)2.50319617
88Hyperphosphaturia (HP:0003109)2.50226433
89Pancreatic cysts (HP:0001737)2.49796475
90Lethargy (HP:0001254)2.46294491
91Congenital primary aphakia (HP:0007707)2.44484838
92Abnormality of pyrimidine metabolism (HP:0004353)2.43928925
93Stenosis of the external auditory canal (HP:0000402)2.43388473
94Supernumerary spleens (HP:0009799)2.43214065
95Vomiting (HP:0002013)2.41169142
96Vacuolated lymphocytes (HP:0001922)2.40391326
97Renal tubular dysfunction (HP:0000124)2.39212043
98Vaginal atresia (HP:0000148)2.37840932
99Nephrogenic diabetes insipidus (HP:0009806)2.34515255
100Genital tract atresia (HP:0001827)2.32332708
101Occipital encephalocele (HP:0002085)2.31329732
102Aplasia/Hypoplasia of the tongue (HP:0010295)2.27201529
103Anophthalmia (HP:0000528)2.25688258
104Abnormality of potassium homeostasis (HP:0011042)2.24697968
105Gait imbalance (HP:0002141)2.24200292
106Joint hemorrhage (HP:0005261)2.21101056
107Abnormal enzyme/coenzyme activity (HP:0012379)2.20886973
108Abnormal respiratory motile cilium physiology (HP:0012261)2.20468592
109Postaxial foot polydactyly (HP:0001830)2.17741037
110Bile duct proliferation (HP:0001408)2.17318869
111Abnormal biliary tract physiology (HP:0012439)2.17318869
112Methylmalonic aciduria (HP:0012120)2.16590150
113Confusion (HP:0001289)2.15529382
114Conjugated hyperbilirubinemia (HP:0002908)2.15470657
115Dehydration (HP:0001944)2.14232288
116Increased serum pyruvate (HP:0003542)2.14013734
117Depressed nasal ridge (HP:0000457)2.13192883
118Malnutrition (HP:0004395)2.11191360
119Fat malabsorption (HP:0002630)2.08765287
120Increased intramyocellular lipid droplets (HP:0012240)2.08636375
121Abnormality of alkaline phosphatase activity (HP:0004379)2.08139763
122Abnormal ciliary motility (HP:0012262)2.06822938
123Triphalangeal thumb (HP:0001199)2.06314900
124Postaxial hand polydactyly (HP:0001162)2.05410891
125Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.02219085
126Absent septum pellucidum (HP:0001331)2.00514458
127Short tibia (HP:0005736)1.97764672
128Exertional dyspnea (HP:0002875)1.96745678
129Nausea (HP:0002018)1.95863574
130Maternal diabetes (HP:0009800)1.95575458
131Widely patent fontanelles and sutures (HP:0004492)1.94992047
132Abnormality of methionine metabolism (HP:0010901)1.93497484
133Deep venous thrombosis (HP:0002625)1.93346038
134Nephronophthisis (HP:0000090)1.92374655
135Abnormality of renal resorption (HP:0011038)1.91930487
136Chronic hepatic failure (HP:0100626)1.91866178
137Congenital, generalized hypertrichosis (HP:0004540)1.91682663
138Delayed epiphyseal ossification (HP:0002663)1.90277972
139Spastic diplegia (HP:0001264)1.90208974
140Vitreoretinal degeneration (HP:0000655)1.89443802
141Sensorimotor neuropathy (HP:0007141)1.87186463
142Pancreatitis (HP:0001733)1.86080652
143Prolonged partial thromboplastin time (HP:0003645)1.84781014
144Elevated alkaline phosphatase (HP:0003155)1.83859579
145Abnormality of the middle phalanges of the toes (HP:0010183)1.83776549
146Broad foot (HP:0001769)1.83596673
147Neonatal onset (HP:0003623)1.83016817
148Opisthotonus (HP:0002179)1.80139782
149Abnormal tarsal ossification (HP:0008369)1.79270538
150Cerebral edema (HP:0002181)1.78600599
151Rhinitis (HP:0012384)1.78488730
152Hepatocellular carcinoma (HP:0001402)1.78028898
153Duplication of thumb phalanx (HP:0009942)1.77793809
154Sclerocornea (HP:0000647)1.77597493
155Cystic liver disease (HP:0006706)1.77478818
156Facial shape deformation (HP:0011334)1.76847145
157Potter facies (HP:0002009)1.76847145
158Median cleft lip (HP:0000161)1.76614834
159Anencephaly (HP:0002323)1.76370973
160Hyponatremia (HP:0002902)1.76360429
161Chondrocalcinosis (HP:0000934)1.76158771
162Abnormality of sodium homeostasis (HP:0010931)1.75710298
163Broad metatarsal (HP:0001783)1.73485694
164Congenital hepatic fibrosis (HP:0002612)1.73250200
165Beaking of vertebral bodies (HP:0004568)1.73139126
166Respiratory failure (HP:0002878)1.72976337
167Preaxial hand polydactyly (HP:0001177)1.72350087
168Type 2 muscle fiber atrophy (HP:0003554)1.72030492
169Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.71120207
170Abnormality of the renal medulla (HP:0100957)1.70213284
171Abnormality of glycolysis (HP:0004366)1.69735912
172Increased muscle lipid content (HP:0009058)1.69645330
173Optic nerve hypoplasia (HP:0000609)1.67472484
174Male pseudohermaphroditism (HP:0000037)1.67184342
175Abnormal lung lobation (HP:0002101)1.67058399
176Methylmalonic acidemia (HP:0002912)1.65763943
177Abnormality of the vitamin B12 metabolism (HP:0004341)1.65677714
178Lactic acidosis (HP:0003128)1.65532022
179Renal hypoplasia (HP:0000089)1.65426005
180Aplasia/Hypoplasia of the tibia (HP:0005772)1.65119580
181Complement deficiency (HP:0004431)1.63272770
182Hypoplastic pelvis (HP:0008839)1.62446595
183Hypobetalipoproteinemia (HP:0003563)1.62384278
184Patchy hypopigmentation of hair (HP:0011365)1.59625549
185Decreased activity of mitochondrial respiratory chain (HP:0008972)1.59480625

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK36.82321893
2WNK46.10897189
3OXSR15.60197634
4BCKDK5.42700100
5VRK23.42926155
6MAPK152.83514115
7STK38L2.66904923
8STK392.27447414
9BUB12.07117873
10BMPR1B2.00136033
11VRK11.93921929
12EPHB21.91445648
13ACVR1B1.88862761
14CDK191.86644274
15GRK11.85459991
16EPHA41.85454134
17SRPK11.82940600
18SGK4941.82573723
19SGK2231.82573723
20PBK1.80352150
21PLK31.68398107
22TGFBR21.67544472
23SGK21.64226892
24MST1R1.61458012
25MAP4K21.60752932
26MKNK21.59512399
27CDC71.57075204
28DYRK31.54286475
29INSRR1.53986116
30TRIM281.52101554
31BCR1.50325811
32DYRK21.49898882
33FGFR21.48556507
34IRAK31.42426063
35MAP3K141.39128213
36FGFR41.38146090
37NME21.37736966
38PASK1.31433540
39TAF11.31400227
40PLK41.26415845
41TNIK1.20263687
42IKBKE1.19204766
43SGK31.18929628
44DDR21.17262236
45BRSK21.11289045
46WNK11.10132571
47PLK21.08939548
48PDK41.08832563
49PDK31.08832563
50TTK1.05593479
51MAP3K41.02838789
52STK241.00078276
53MST40.99759232
54ZAK0.97573240
55STK160.94492060
56ERN10.94263753
57ADRBK20.94163963
58TIE10.92269416
59PINK10.92073932
60BTK0.91303366
61SIK10.91042862
62EIF2AK30.90638300
63NME10.89740605
64NLK0.89644082
65MAP3K30.88735941
66LIMK10.88057746
67IRAK10.86202864
68LMTK20.84904864
69PLK10.82837476
70PIM10.82044656
71KIT0.81163679
72CSNK1G30.81159668
73TYK20.80281677
74ERBB30.79458334
75ERBB40.77877408
76GSK3A0.77579595
77FGFR10.77447486
78LATS10.76820238
79MAP2K60.76571321
80BLK0.75896923
81MAPK110.75491292
82CSNK1G20.74895247
83TAOK20.74181769
84PDK20.73681367
85MKNK10.71811665
86PRKCE0.70308537
87CSNK1A1L0.68165501
88AURKB0.67249732
89GRK70.65129738
90ABL20.64844572
91IKBKB0.62849878
92MAP3K120.62778082
93MAP2K70.62677217
94WEE10.62648775
95MAP2K30.61742112
96CASK0.59715255
97PTK60.59142927
98PRKAA20.59126627
99TEC0.57271695
100CSNK2A10.56996599
101TXK0.54502565
102JAK30.53890048
103MUSK0.53750258
104MAP3K130.51940190
105NTRK20.51255234
106IRAK20.50780227
107FRK0.50153339
108RPS6KA40.50070734
109CHUK0.49542113
110NEK10.49389526
111CSNK2A20.49259303
112PIK3CG0.48715587
113OBSCN0.48061738
114CDK80.47440496
115BRSK10.46860659
116NUAK10.46588664
117PIM20.44577737
118DYRK1A0.44466190
119PTK20.44151485
120MYLK0.43894697
121ERBB20.43728016
122NEK90.43259556
123SGK10.43226288
124STK30.42465991
125TGFBR10.41521752
126MET0.41509195
127TBK10.41294603
128ADRBK10.40542169
129ATR0.39696255
130TAOK30.39469721
131EIF2AK20.39346483
132NEK60.39110390
133MAP3K70.37887788
134PRKCZ0.37818033
135STK380.37394716
136NEK20.37388960
137CSNK1A10.37316678
138LRRK20.36516692
139PRKACA0.36148682
140AKT20.35836570
141MAPK130.35156737
142DAPK30.35097694
143NTRK10.33884147
144CHEK20.33632420
145MAPKAPK30.32713109
146PRKACB0.32555786
147CAMK2A0.31695174
148PRKCD0.30974567
149PRKG20.30623337
150PRKCI0.27455001
151DYRK1B0.26318872
152CSNK1G10.25932611
153MAPK40.25151086
154FLT30.24381660
155PRKACG0.22376544
156IRAK40.20766413
157LYN0.20073750
158MAPK120.19851733
159IGF1R0.19650451
160CSF1R0.19629629
161PRKCG0.19158212
162MAPK30.18655846
163PRKCA0.18488928
164PIK3CA0.17303871
165JAK20.17021655
166PRKAA10.16875573

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.94628407
2Ribosome_Homo sapiens_hsa030103.81763591
3Pentose and glucuronate interconversions_Homo sapiens_hsa000403.56586620
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.09127456
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.95929626
6Propanoate metabolism_Homo sapiens_hsa006402.79303673
7* Butanoate metabolism_Homo sapiens_hsa006502.76784932
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.76233318
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.72845371
10Peroxisome_Homo sapiens_hsa041462.70528291
11Tryptophan metabolism_Homo sapiens_hsa003802.61273310
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.50612161
13Proteasome_Homo sapiens_hsa030502.44294638
14Fatty acid degradation_Homo sapiens_hsa000712.42144289
15Protein export_Homo sapiens_hsa030602.32138613
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.15648812
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.15276580
18beta-Alanine metabolism_Homo sapiens_hsa004102.13527242
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.07061190
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.06477080
21Sulfur metabolism_Homo sapiens_hsa009201.90125455
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.86459644
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.84258170
24Chemical carcinogenesis_Homo sapiens_hsa052041.82528585
25Huntingtons disease_Homo sapiens_hsa050161.79645424
26Glutathione metabolism_Homo sapiens_hsa004801.78508552
27Vitamin digestion and absorption_Homo sapiens_hsa049771.76809753
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.76358096
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.76129677
30Pyruvate metabolism_Homo sapiens_hsa006201.73199922
31* Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69532990
32Histidine metabolism_Homo sapiens_hsa003401.67762184
33Arginine biosynthesis_Homo sapiens_hsa002201.66386134
34Fatty acid metabolism_Homo sapiens_hsa012121.63790744
35Mismatch repair_Homo sapiens_hsa034301.61580815
36Retinol metabolism_Homo sapiens_hsa008301.61499793
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.60297117
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.57584528
39Starch and sucrose metabolism_Homo sapiens_hsa005001.51796663
40Selenocompound metabolism_Homo sapiens_hsa004501.46979435
41Arginine and proline metabolism_Homo sapiens_hsa003301.45584362
42Alzheimers disease_Homo sapiens_hsa050101.45451668
43PPAR signaling pathway_Homo sapiens_hsa033201.45398766
44RNA polymerase_Homo sapiens_hsa030201.43431717
45Bile secretion_Homo sapiens_hsa049761.38260827
46Nitrogen metabolism_Homo sapiens_hsa009101.31331257
47Carbon metabolism_Homo sapiens_hsa012001.31247069
48Sulfur relay system_Homo sapiens_hsa041221.30366090
49Phenylalanine metabolism_Homo sapiens_hsa003601.24587383
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.24233829
51Complement and coagulation cascades_Homo sapiens_hsa046101.21659680
52Basal cell carcinoma_Homo sapiens_hsa052171.18007093
53Basal transcription factors_Homo sapiens_hsa030221.17642651
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.14744379
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.14556172
56Folate biosynthesis_Homo sapiens_hsa007901.13453805
57Lysine degradation_Homo sapiens_hsa003101.12105087
58Cardiac muscle contraction_Homo sapiens_hsa042601.09669009
59Base excision repair_Homo sapiens_hsa034101.09640761
60Nucleotide excision repair_Homo sapiens_hsa034201.09299577
61Homologous recombination_Homo sapiens_hsa034401.08023673
62Fatty acid elongation_Homo sapiens_hsa000621.07746679
63Non-homologous end-joining_Homo sapiens_hsa034501.07479347
64Biosynthesis of amino acids_Homo sapiens_hsa012301.05096554
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.04569825
66Cysteine and methionine metabolism_Homo sapiens_hsa002701.02281458
67RNA degradation_Homo sapiens_hsa030181.01389542
68Spliceosome_Homo sapiens_hsa030400.98897764
69Fanconi anemia pathway_Homo sapiens_hsa034600.95997928
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95058416
71Other glycan degradation_Homo sapiens_hsa005110.94951149
72Hedgehog signaling pathway_Homo sapiens_hsa043400.92712639
73DNA replication_Homo sapiens_hsa030300.88937774
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84922130
75Caffeine metabolism_Homo sapiens_hsa002320.83361886
76One carbon pool by folate_Homo sapiens_hsa006700.83329376
77Collecting duct acid secretion_Homo sapiens_hsa049660.82926302
78Tyrosine metabolism_Homo sapiens_hsa003500.82072541
79Glycerolipid metabolism_Homo sapiens_hsa005610.78142280
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76068811
81ABC transporters_Homo sapiens_hsa020100.75908584
82Fructose and mannose metabolism_Homo sapiens_hsa000510.74594711
83Mineral absorption_Homo sapiens_hsa049780.73061740
84* Metabolic pathways_Homo sapiens_hsa011000.68729471
85Protein digestion and absorption_Homo sapiens_hsa049740.67404954
86Purine metabolism_Homo sapiens_hsa002300.62087615
87Pentose phosphate pathway_Homo sapiens_hsa000300.60320800
88Arachidonic acid metabolism_Homo sapiens_hsa005900.59151684
89Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.57287911
90RNA transport_Homo sapiens_hsa030130.56311934
91Staphylococcus aureus infection_Homo sapiens_hsa051500.52869095
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.50944317
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50508112
94Vitamin B6 metabolism_Homo sapiens_hsa007500.49474454
95Galactose metabolism_Homo sapiens_hsa000520.48542039
96Steroid biosynthesis_Homo sapiens_hsa001000.47296521
97Hippo signaling pathway_Homo sapiens_hsa043900.47170939
98TGF-beta signaling pathway_Homo sapiens_hsa043500.44071936
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.39296318
100Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.31710162
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30566873
102Cell cycle_Homo sapiens_hsa041100.29706756
103Renin-angiotensin system_Homo sapiens_hsa046140.29189341
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.19362774
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19016036
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18971937
107Oxidative phosphorylation_Homo sapiens_hsa001900.14574338
108Lysosome_Homo sapiens_hsa041420.12827489
109Sphingolipid metabolism_Homo sapiens_hsa006000.11109163
110Fat digestion and absorption_Homo sapiens_hsa049750.10419228
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.09518280
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.08197709
113Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.08057609
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.06112514
115Pyrimidine metabolism_Homo sapiens_hsa002400.05868027
116Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.02202072
117Thyroid hormone synthesis_Homo sapiens_hsa049180.02081173
118Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0959716
119Malaria_Homo sapiens_hsa05144-0.0953678
120Parkinsons disease_Homo sapiens_hsa05012-0.0924594
121Insulin resistance_Homo sapiens_hsa04931-0.0808997
122Hepatitis C_Homo sapiens_hsa05160-0.0482906
123Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0449587
124Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0383357
125Linoleic acid metabolism_Homo sapiens_hsa00591-0.0362462
126Rheumatoid arthritis_Homo sapiens_hsa05323-0.0335651
127RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.0108452
128Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.0092962
129Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.0039683

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