BDH2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tryptophan metabolic process (GO:0006568)6.43821548
2DNA deamination (GO:0045006)6.35338354
3tryptophan catabolic process (GO:0006569)6.07704428
4indole-containing compound catabolic process (GO:0042436)6.07704428
5indolalkylamine catabolic process (GO:0046218)6.07704428
6kynurenine metabolic process (GO:0070189)5.87563988
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.27889371
8cytidine metabolic process (GO:0046087)4.81123790
9cytidine catabolic process (GO:0006216)4.81123790
10cytidine deamination (GO:0009972)4.81123790
11indolalkylamine metabolic process (GO:0006586)4.79032163
12protein complex biogenesis (GO:0070271)4.72726416
13oxidative phosphorylation (GO:0006119)4.55030856
14rRNA modification (GO:0000154)4.47648006
15cytochrome complex assembly (GO:0017004)4.45011625
16pyrimidine ribonucleoside catabolic process (GO:0046133)4.33833937
17mitochondrial respiratory chain complex assembly (GO:0033108)4.32106739
18rRNA methylation (GO:0031167)4.27368613
19tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.25955778
20RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.25955778
21amine catabolic process (GO:0009310)4.16002143
22cellular biogenic amine catabolic process (GO:0042402)4.16002143
23aromatic amino acid family catabolic process (GO:0009074)3.83701467
24protein maturation by protein folding (GO:0022417)3.81561030
25respiratory chain complex IV assembly (GO:0008535)3.79166933
26L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.71141294
27mitochondrial respiratory chain complex I assembly (GO:0032981)3.63643966
28NADH dehydrogenase complex assembly (GO:0010257)3.63643966
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.63643966
30mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.44457583
31metallo-sulfur cluster assembly (GO:0031163)3.44155105
32iron-sulfur cluster assembly (GO:0016226)3.44155105
33ubiquinone biosynthetic process (GO:0006744)3.43752842
34GMP metabolic process (GO:0046037)3.41033803
35positive regulation of protein homodimerization activity (GO:0090073)3.34586580
36negative regulation of calcium ion transport into cytosol (GO:0010523)3.31032741
37negative regulation by host of viral transcription (GO:0043922)3.30801196
38positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.28852905
39amino acid salvage (GO:0043102)3.27820949
40L-methionine salvage (GO:0071267)3.27820949
41L-methionine biosynthetic process (GO:0071265)3.27820949
42indole-containing compound metabolic process (GO:0042430)3.27661782
43energy coupled proton transport, down electrochemical gradient (GO:0015985)3.22979601
44ATP synthesis coupled proton transport (GO:0015986)3.22979601
45negative regulation of neurotransmitter transport (GO:0051589)3.21785495
46regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.20909873
47lysine catabolic process (GO:0006554)3.20893400
48lysine metabolic process (GO:0006553)3.20893400
49protein neddylation (GO:0045116)3.19632797
50aldehyde catabolic process (GO:0046185)3.19272373
51DNA demethylation (GO:0080111)3.18137785
52aromatic amino acid family metabolic process (GO:0009072)3.17882967
53positive regulation of prostaglandin secretion (GO:0032308)3.11535038
54lysosome localization (GO:0032418)3.10379676
55S-adenosylmethionine metabolic process (GO:0046500)3.10132970
56phosphatidylinositol acyl-chain remodeling (GO:0036149)3.09758549
57ubiquinone metabolic process (GO:0006743)3.08804160
58cornea development in camera-type eye (GO:0061303)3.04543923
59mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.02672780
60GPI anchor biosynthetic process (GO:0006506)2.98581394
61regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.96494565
62aspartate family amino acid catabolic process (GO:0009068)2.95288877
63mannosylation (GO:0097502)2.94831810
64transcription from mitochondrial promoter (GO:0006390)2.90335021
65cell fate commitment involved in formation of primary germ layer (GO:0060795)2.87228294
66signal peptide processing (GO:0006465)2.86003927
67GPI anchor metabolic process (GO:0006505)2.84991179
68quinone biosynthetic process (GO:1901663)2.83750705
69retinal cone cell development (GO:0046549)2.81449723
70mast cell activation involved in immune response (GO:0002279)2.79618463
71mast cell degranulation (GO:0043303)2.79618463
72preassembly of GPI anchor in ER membrane (GO:0016254)2.77817453
73respiratory electron transport chain (GO:0022904)2.76762032
74negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.76564146
75electron transport chain (GO:0022900)2.76285720
76response to interferon-beta (GO:0035456)2.73965004
77chaperone mediated protein folding requiring cofactor (GO:0051085)2.73952806
78NAD biosynthetic process (GO:0009435)2.71076339
79regulation of cellular amino acid metabolic process (GO:0006521)2.69859338
80negative regulation of neurotransmitter secretion (GO:0046929)2.69327311
81benzene-containing compound metabolic process (GO:0042537)2.67233027
82DNA double-strand break processing (GO:0000729)2.65155405
83protein deneddylation (GO:0000338)2.64455617
84histamine transport (GO:0051608)2.61736414
85oxidative demethylation (GO:0070989)2.61591202
86proteasome assembly (GO:0043248)2.59499036
87DNA damage response, detection of DNA damage (GO:0042769)2.58142362
88immunoglobulin mediated immune response (GO:0016064)2.54687478
89dicarboxylic acid biosynthetic process (GO:0043650)2.52768694
90chaperone-mediated protein transport (GO:0072321)2.52730163
91behavioral response to nicotine (GO:0035095)2.51785103
92cardiolipin metabolic process (GO:0032048)2.51415419
93cobalamin metabolic process (GO:0009235)2.51040415
94cullin deneddylation (GO:0010388)2.49153875
95nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.48990150
96DNA dealkylation (GO:0035510)2.48652555
97regulation of hexokinase activity (GO:1903299)2.48519682
98regulation of glucokinase activity (GO:0033131)2.48519682
99regulation of prostaglandin secretion (GO:0032306)2.47313940
100cytolysis (GO:0019835)2.46344791

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ELF1_17652178_ChIP-ChIP_JURKAT_Human5.23739874
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.19049967
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.96131230
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.93392003
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.68363226
6ZNF274_21170338_ChIP-Seq_K562_Hela3.48564436
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.24802445
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.18819500
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.85594058
10IGF1R_20145208_ChIP-Seq_DFB_Human2.53407187
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.52494174
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.45235774
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.43381908
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.33397240
15SRF_21415370_ChIP-Seq_HL-1_Mouse2.32620350
16VDR_23849224_ChIP-Seq_CD4+_Human2.26368708
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.25058006
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15348820
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.02903542
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.93768269
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.92593947
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.90431973
23EWS_26573619_Chip-Seq_HEK293_Human1.90241920
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.85901264
25ELK1_19687146_ChIP-ChIP_HELA_Human1.84640191
26VDR_22108803_ChIP-Seq_LS180_Human1.83223017
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.79509501
28FOXP3_21729870_ChIP-Seq_TREG_Human1.76298422
29AR_20517297_ChIP-Seq_VCAP_Human1.72698254
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72078283
31IRF8_22096565_ChIP-ChIP_GC-B_Human1.54101339
32FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.52767201
33FOXA1_27270436_Chip-Seq_PROSTATE_Human1.50440188
34FOXA1_25329375_ChIP-Seq_VCAP_Human1.50440188
35FOXA1_21572438_ChIP-Seq_LNCaP_Human1.48706601
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46017431
37GATA3_26560356_Chip-Seq_TH2_Human1.44700038
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.42517154
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41823563
40EGR1_23403033_ChIP-Seq_LIVER_Mouse1.39096888
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.38118504
42GABP_19822575_ChIP-Seq_HepG2_Human1.36195010
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35516733
44ETV2_25802403_ChIP-Seq_MESCs_Mouse1.34851040
45GBX2_23144817_ChIP-Seq_PC3_Human1.34691477
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32593828
47EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.32355729
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.31194008
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30038151
50CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28694787
51NANOG_19829295_ChIP-Seq_ESCs_Human1.28374442
52SOX2_19829295_ChIP-Seq_ESCs_Human1.28374442
53TAF2_19829295_ChIP-Seq_ESCs_Human1.27724536
54TP53_22573176_ChIP-Seq_HFKS_Human1.27539463
55CBP_20019798_ChIP-Seq_JUKART_Human1.27187860
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27187860
57LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.26793499
58STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.25839009
59CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22744890
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17311626
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17195062
62LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17188476
63RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.16875126
64CIITA_25753668_ChIP-Seq_RAJI_Human1.16177263
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15558026
66FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14538830
67EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.12082069
68LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10523876
69ERG_20517297_ChIP-Seq_VCAP_Human1.09306551
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09053612
71GATA3_21878914_ChIP-Seq_MCF-7_Human1.08890513
72P53_21459846_ChIP-Seq_SAOS-2_Human1.08439598
73MYB_26560356_Chip-Seq_TH2_Human1.07357204
74MYC_18358816_ChIP-ChIP_MESCs_Mouse1.07342883
75RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06715131
76GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06605135
77GATA3_26560356_Chip-Seq_TH1_Human1.06183919
78AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04872651
79HTT_18923047_ChIP-ChIP_STHdh_Human1.03389624
80ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02374309
81YY1_21170310_ChIP-Seq_MESCs_Mouse1.00908046
82TAF15_26573619_Chip-Seq_HEK293_Human1.00179549
83CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98449740
84E2F4_17652178_ChIP-ChIP_JURKAT_Human0.97826347
85TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96673525
86GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.96624673
87FUS_26573619_Chip-Seq_HEK293_Human0.96522066
88MYC_18940864_ChIP-ChIP_HL60_Human0.96324498
89IRF8_21731497_ChIP-ChIP_J774_Mouse0.96204624
90FOXH1_21741376_ChIP-Seq_EPCs_Human0.94431581
91PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.94016813
92CRX_20693478_ChIP-Seq_RETINA_Mouse0.92937840
93PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91853493
94HOXB7_26014856_ChIP-Seq_BT474_Human0.91422500
95KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91155785
96ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89697048
97CEBPB_22108803_ChIP-Seq_LS180_Human0.89572992
98PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89227722
99CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.89078910
100E2F1_18555785_ChIP-Seq_MESCs_Mouse0.88492053

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system4.93331466
2MP0008875_abnormal_xenobiotic_pharmacok4.75843901
3MP0005167_abnormal_blood-brain_barrier3.06983125
4MP0003724_increased_susceptibility_to2.78377022
5MP0002166_altered_tumor_susceptibility2.76817932
6MP0002163_abnormal_gland_morphology2.58303085
7MP0008775_abnormal_heart_ventricle2.38662290
8MP0002006_tumorigenesis2.24891203
9MP0004145_abnormal_muscle_electrophysio2.23222845
10MP0004084_abnormal_cardiac_muscle2.19521395
11MP0009333_abnormal_splenocyte_physiolog2.17621382
12MP0005646_abnormal_pituitary_gland2.13452050
13MP0009697_abnormal_copulation2.11906786
14MP0009780_abnormal_chondrocyte_physiolo2.09039371
15MP0001968_abnormal_touch/_nociception2.01227640
16MP0003252_abnormal_bile_duct1.95734541
17MP0002837_dystrophic_cardiac_calcinosis1.95230600
18MP0001835_abnormal_antigen_presentation1.94747717
19MP0002736_abnormal_nociception_after1.88365134
20MP0005671_abnormal_response_to1.83971948
21MP0005379_endocrine/exocrine_gland_phen1.82281651
22MP0002277_abnormal_respiratory_mucosa1.73527871
23MP0001764_abnormal_homeostasis1.63242556
24MP0004043_abnormal_pH_regulation1.55931593
25MP0001919_abnormal_reproductive_system1.51993209
26MP0002148_abnormal_hypersensitivity_rea1.50502623
27MP0008872_abnormal_physiological_respon1.49760354
28MP0002876_abnormal_thyroid_physiology1.49042835
29MP0009785_altered_susceptibility_to1.45107306
30MP0003186_abnormal_redox_activity1.44729714
31MP0002102_abnormal_ear_morphology1.42701078
32MP0005220_abnormal_exocrine_pancreas1.40835705
33MP0004036_abnormal_muscle_relaxation1.38835691
34MP0005389_reproductive_system_phenotype1.36506313
35MP0006036_abnormal_mitochondrial_physio1.34576402
36MP0002928_abnormal_bile_duct1.30202784
37MP0003950_abnormal_plasma_membrane1.30096014
38MP0002160_abnormal_reproductive_system1.29911235
39MP0001529_abnormal_vocalization1.27423634
40MP0000749_muscle_degeneration1.23759693
41MP0004215_abnormal_myocardial_fiber1.18895397
42MP0002132_abnormal_respiratory_system1.17896268
43MP0005410_abnormal_fertilization1.16786110
44MP0008877_abnormal_DNA_methylation1.16446309
45MP0009643_abnormal_urine_homeostasis1.14477974
46MP0001905_abnormal_dopamine_level1.11885786
47MP0000613_abnormal_salivary_gland1.10600863
48MP0005083_abnormal_biliary_tract1.09504413
49MP0003075_altered_response_to1.09081723
50MP0005551_abnormal_eye_electrophysiolog1.08181797
51MP0006082_CNS_inflammation1.06030244
52MP0003693_abnormal_embryo_hatching1.05690676
53MP0005165_increased_susceptibility_to1.04726910
54MP0006292_abnormal_olfactory_placode1.04345737
55MP0003763_abnormal_thymus_physiology1.03072616
56MP0005084_abnormal_gallbladder_morpholo1.01448883
57MP0001790_abnormal_immune_system1.01120903
58MP0005387_immune_system_phenotype1.01120903
59MP0003806_abnormal_nucleotide_metabolis1.00077818
60MP0003195_calcinosis0.97947462
61MP0001800_abnormal_humoral_immune0.97761626
62MP0005365_abnormal_bile_salt0.97516136
63MP0005000_abnormal_immune_tolerance0.97321363
64MP0005253_abnormal_eye_physiology0.96875209
65MP0005332_abnormal_amino_acid0.96838383
66MP0003279_aneurysm0.96726312
67MP0006072_abnormal_retinal_apoptosis0.96659668
68MP0005085_abnormal_gallbladder_physiolo0.96538100
69MP0003045_fibrosis0.93830780
70MP0003646_muscle_fatigue0.93730669
71MP0000358_abnormal_cell_content/0.92227990
72MP0000569_abnormal_digit_pigmentation0.90970993
73MP0010386_abnormal_urinary_bladder0.89017087
74MP0005174_abnormal_tail_pigmentation0.87497751
75MP0008058_abnormal_DNA_repair0.86164224
76MP0003866_abnormal_defecation0.85513771
77MP0000639_abnormal_adrenal_gland0.84755718
78MP0002420_abnormal_adaptive_immunity0.84186964
79MP0006276_abnormal_autonomic_nervous0.83524413
80MP0000427_abnormal_hair_cycle0.80849440
81MP0002282_abnormal_trachea_morphology0.80382261
82MP0005645_abnormal_hypothalamus_physiol0.79905592
83MP0001819_abnormal_immune_cell0.79745130
84MP0010094_abnormal_chromosome_stability0.78226668
85MP0005360_urolithiasis0.78177874
86MP0002452_abnormal_antigen_presenting0.76766583
87MP0001661_extended_life_span0.76675912
88MP0003638_abnormal_response/metabolism_0.74792670
89MP0000230_abnormal_systemic_arterial0.71858193
90MP0001664_abnormal_digestion0.71529210
91MP0005636_abnormal_mineral_homeostasis0.70390357
92MP0005330_cardiomyopathy0.70213458
93MP0009764_decreased_sensitivity_to0.69829504
94MP0002909_abnormal_adrenal_gland0.69802393
95MP0004147_increased_porphyrin_level0.69781371
96MP0000689_abnormal_spleen_morphology0.69630228
97MP0006035_abnormal_mitochondrial_morpho0.69278885
98MP0003718_maternal_effect0.69249198
99MP0004484_altered_response_of0.66973719
100MP0000538_abnormal_urinary_bladder0.66816105

Predicted human phenotypes

RankGene SetZ-score
1Type 2 muscle fiber atrophy (HP:0003554)4.84299572
2Panhypogammaglobulinemia (HP:0003139)4.32988944
3Muscle fiber atrophy (HP:0100295)4.31783789
4Mitochondrial inheritance (HP:0001427)3.90655807
5Abnormal mitochondria in muscle tissue (HP:0008316)3.66945857
6Increased CSF lactate (HP:0002490)3.64545493
7Hepatocellular necrosis (HP:0001404)3.56824334
8Acute necrotizing encephalopathy (HP:0006965)3.54935910
9Hepatic necrosis (HP:0002605)3.33577167
103-Methylglutaconic aciduria (HP:0003535)3.25602686
11Testicular atrophy (HP:0000029)3.23386789
12Lipid accumulation in hepatocytes (HP:0006561)3.18740807
13Hypoproteinemia (HP:0003075)3.17371381
14Methylmalonic aciduria (HP:0012120)3.14754370
15Increased intramyocellular lipid droplets (HP:0012240)3.13568969
16Progressive macrocephaly (HP:0004481)3.05393958
17Acute encephalopathy (HP:0006846)3.03155212
18Hypoplasia of the uterus (HP:0000013)3.01038909
19Methylmalonic acidemia (HP:0002912)2.96511506
20Agammaglobulinemia (HP:0004432)2.95591929
21Azoospermia (HP:0000027)2.94946592
22Increased hepatocellular lipid droplets (HP:0006565)2.94734249
23Hyperglycinuria (HP:0003108)2.93878022
24Increased muscle lipid content (HP:0009058)2.92247409
25Tubulointerstitial fibrosis (HP:0005576)2.91710812
26Elevated erythrocyte sedimentation rate (HP:0003565)2.88819188
27Abnormality of glycine metabolism (HP:0010895)2.83241017
28Abnormality of serine family amino acid metabolism (HP:0010894)2.83241017
29Hyperglycinemia (HP:0002154)2.82848295
30Malignant hyperthermia (HP:0002047)2.82775518
31Renal Fanconi syndrome (HP:0001994)2.74048272
32Opisthotonus (HP:0002179)2.73624171
33Dicarboxylic aciduria (HP:0003215)2.65898672
34Abnormality of dicarboxylic acid metabolism (HP:0010995)2.65898672
35Aplasia/hypoplasia of the uterus (HP:0008684)2.65643662
36Abnormality of midbrain morphology (HP:0002418)2.62070846
37Molar tooth sign on MRI (HP:0002419)2.62070846
38Aplastic anemia (HP:0001915)2.60356412
39Cerebral edema (HP:0002181)2.59970935
40Weak cry (HP:0001612)2.57775230
41Abnormality of the renal cortex (HP:0011035)2.57377856
42Gaze-evoked nystagmus (HP:0000640)2.54756742
43True hermaphroditism (HP:0010459)2.54442914
44Reduced antithrombin III activity (HP:0001976)2.53341417
45Abnormal delayed hypersensitivity skin test (HP:0002963)2.52243530
46Pancreatic cysts (HP:0001737)2.51319699
47Increased serum lactate (HP:0002151)2.50927943
48Abnormal spermatogenesis (HP:0008669)2.49029069
49Calf muscle hypertrophy (HP:0008981)2.48216559
50Type I transferrin isoform profile (HP:0003642)2.44418766
51Abnormal protein glycosylation (HP:0012346)2.43871960
52Abnormal glycosylation (HP:0012345)2.43871960
53Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.43871960
54Abnormal protein N-linked glycosylation (HP:0012347)2.43871960
55Severe combined immunodeficiency (HP:0004430)2.37632480
56Respiratory failure (HP:0002878)2.32888360
57Lactic acidosis (HP:0003128)2.32354439
58Pancreatic fibrosis (HP:0100732)2.30599500
59Thyroiditis (HP:0100646)2.29751080
60Tubulointerstitial abnormality (HP:0001969)2.27489662
61Ketosis (HP:0001946)2.23327141
62Abnormality of the prostate (HP:0008775)2.18209500
63Abnormal biliary tract physiology (HP:0012439)2.16463277
64Bile duct proliferation (HP:0001408)2.16463277
65Lethargy (HP:0001254)2.15940655
66Disproportionate short-trunk short stature (HP:0003521)2.15160783
67Spastic paraparesis (HP:0002313)2.14881402
68Nephronophthisis (HP:0000090)2.14717901
69Congenital stationary night blindness (HP:0007642)2.14393781
70Decreased activity of mitochondrial respiratory chain (HP:0008972)2.14393168
71Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.14393168
72Muscle hypertrophy of the lower extremities (HP:0008968)2.14066678
73Abnormality of the phalanges of the 2nd finger (HP:0009541)2.13701295
74Periodontitis (HP:0000704)2.02796904
75CNS demyelination (HP:0007305)2.01417531
76Abnormality of the renal medulla (HP:0100957)1.99847810
77Abnormality of lateral ventricle (HP:0030047)1.99027608
78IgM deficiency (HP:0002850)1.98926454
79Attenuation of retinal blood vessels (HP:0007843)1.97921295
80Large eyes (HP:0001090)1.95641727
81Abnormality of the proximal phalanges of the hand (HP:0009834)1.95225937
82Fatigable weakness (HP:0003473)1.94987558
83Abnormality of the neuromuscular junction (HP:0003398)1.94987558
84Posterior subcapsular cataract (HP:0007787)1.94775401
85Renal cortical cysts (HP:0000803)1.93703732
86Chronic mucocutaneous candidiasis (HP:0002728)1.91556660
87Recurrent cutaneous fungal infections (HP:0011370)1.91556660
88Abnormality of the vitamin B12 metabolism (HP:0004341)1.90991795
89Amniotic constriction ring (HP:0009775)1.90893206
90Abnormality of placental membranes (HP:0011409)1.90893206
91Exertional dyspnea (HP:0002875)1.89955780
92Congenital, generalized hypertrichosis (HP:0004540)1.89567744
93Aplasia/Hypoplasia involving the musculature (HP:0001460)1.88184525
94Eosinophilia (HP:0001880)1.86341735
95Stomatitis (HP:0010280)1.84828196
96Abnormality of T cells (HP:0002843)1.83703046
97B lymphocytopenia (HP:0010976)1.82024424
98Absent rod-and cone-mediated responses on ERG (HP:0007688)1.81980666
99Abnormality of vitamin B metabolism (HP:0004340)1.81120062
100Mesangial abnormality (HP:0001966)1.80223633

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR1B5.10375665
2BCKDK4.13005249
3MAP4K23.94048664
4VRK23.16424734
5LMTK22.94165309
6CDK82.70548252
7TGFBR12.57153036
8NUAK12.50243561
9TNK22.30844456
10EIF2AK32.25020075
11FRK2.24980990
12MST42.23684664
13ZAK2.16519255
14PLK22.07531350
15PIK3CA2.01261976
16MAPKAPK51.87895917
17KIT1.84567138
18TAOK31.59466073
19MKNK11.57760217
20KDR1.53977350
21VRK11.46804587
22GRK11.44510781
23EIF2AK11.44215068
24FES1.31407810
25DAPK21.31269152
26TLK11.29838294
27TAF11.27811408
28CDK91.22398437
29TESK21.20881931
30BMPR21.18305153
31PIM21.16194226
32OBSCN1.13583712
33PRKG21.06687667
34BCR1.04745265
35LIMK11.04405953
36TIE11.00458515
37SIK30.98168694
38SYK0.97979833
39ADRBK20.96068207
40FLT30.95752944
41ITK0.94645444
42NME20.88066703
43PRKCQ0.88015561
44CDK70.83258773
45RPS6KA50.83049857
46ACVR1B0.82881343
47MET0.82555196
48MAPK130.82486477
49PLK30.81503526
50EPHA30.79875456
51WNK30.79694644
52PINK10.76385616
53FER0.76332743
54PRKCI0.74689256
55TEC0.73712238
56RIPK40.73434445
57RPS6KA40.72226934
58MAP4K10.71672805
59STK160.71363107
60ERN10.70561459
61CSNK1G30.69805763
62ATR0.67841380
63CAMKK20.66350368
64LYN0.66337114
65GRK50.66245720
66CCNB10.64479621
67TBK10.62640339
68TXK0.61345147
69CSNK1G20.58595692
70ABL20.57228621
71INSRR0.56209171
72TRIM280.51350264
73DAPK10.49159058
74EIF2AK20.49032574
75CSNK1A1L0.48443550
76CSNK1G10.48128530
77GRK70.46430528
78PRKCE0.46120697
79CSNK1A10.45574920
80IKBKB0.43810298
81TESK10.43520349
82MAPKAPK30.43040344
83DAPK30.41957913
84CAMK2A0.41380132
85BTK0.41320218
86WNK40.40357369
87OXSR10.38741914
88CAMK10.34478865
89PRKCA0.34389871
90AURKA0.34299755
91ADRBK10.32792417
92ABL10.31260839
93LRRK20.30899575
94CAMK2D0.30070125
95ERBB30.27200386
96HIPK20.24993899
97NEK90.24437404
98LCK0.24011445
99CSNK2A10.23971232
100MYLK0.23705531

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002327.46716475
2Proteasome_Homo sapiens_hsa030502.99636899
3Allograft rejection_Homo sapiens_hsa053302.56855171
4Graft-versus-host disease_Homo sapiens_hsa053322.49330368
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.48368748
6Asthma_Homo sapiens_hsa053102.42551799
7Autoimmune thyroid disease_Homo sapiens_hsa053202.38582639
8Oxidative phosphorylation_Homo sapiens_hsa001902.35876750
9Primary immunodeficiency_Homo sapiens_hsa053402.25160408
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.23617542
11Antigen processing and presentation_Homo sapiens_hsa046122.07371588
12Parkinsons disease_Homo sapiens_hsa050122.04883019
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.00750647
14Type I diabetes mellitus_Homo sapiens_hsa049401.99825912
15Propanoate metabolism_Homo sapiens_hsa006401.79401305
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.74408135
17Tryptophan metabolism_Homo sapiens_hsa003801.67295202
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.63643672
19Protein export_Homo sapiens_hsa030601.57370238
20RNA polymerase_Homo sapiens_hsa030201.45810685
21Peroxisome_Homo sapiens_hsa041461.43530877
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.33690115
23Linoleic acid metabolism_Homo sapiens_hsa005911.33601094
24SNARE interactions in vesicular transport_Homo sapiens_hsa041301.31516898
25Alzheimers disease_Homo sapiens_hsa050101.28994889
26Huntingtons disease_Homo sapiens_hsa050161.27482179
27Butanoate metabolism_Homo sapiens_hsa006501.25207838
28Phototransduction_Homo sapiens_hsa047441.21072486
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15090605
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.11522948
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10679278
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.08312050
33Cardiac muscle contraction_Homo sapiens_hsa042601.07025827
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02527652
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01325168
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.00921011
37Chemical carcinogenesis_Homo sapiens_hsa052041.00679413
38Systemic lupus erythematosus_Homo sapiens_hsa053220.97453504
39Mineral absorption_Homo sapiens_hsa049780.97024965
40Rheumatoid arthritis_Homo sapiens_hsa053230.96789809
41RNA degradation_Homo sapiens_hsa030180.92754629
42Cysteine and methionine metabolism_Homo sapiens_hsa002700.92630934
43Fatty acid elongation_Homo sapiens_hsa000620.92168946
44Olfactory transduction_Homo sapiens_hsa047400.90787124
45Staphylococcus aureus infection_Homo sapiens_hsa051500.89225304
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88131355
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86345642
48One carbon pool by folate_Homo sapiens_hsa006700.84123766
49Retinol metabolism_Homo sapiens_hsa008300.82598088
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.79715495
51Ribosome_Homo sapiens_hsa030100.78515779
52Ether lipid metabolism_Homo sapiens_hsa005650.77961429
53Fatty acid degradation_Homo sapiens_hsa000710.75886262
54Hematopoietic cell lineage_Homo sapiens_hsa046400.75878149
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.75648402
56Fanconi anemia pathway_Homo sapiens_hsa034600.75637181
57Arachidonic acid metabolism_Homo sapiens_hsa005900.75264803
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74047864
59Viral myocarditis_Homo sapiens_hsa054160.73212793
60N-Glycan biosynthesis_Homo sapiens_hsa005100.70421470
61Basal transcription factors_Homo sapiens_hsa030220.68978756
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68535079
63Salivary secretion_Homo sapiens_hsa049700.65512644
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64100635
65Nitrogen metabolism_Homo sapiens_hsa009100.62602065
66Metabolic pathways_Homo sapiens_hsa011000.62442255
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.61939284
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57664898
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55753342
70Purine metabolism_Homo sapiens_hsa002300.55585251
71Pyrimidine metabolism_Homo sapiens_hsa002400.53634534
72Arginine and proline metabolism_Homo sapiens_hsa003300.51776522
73Non-homologous end-joining_Homo sapiens_hsa034500.51147429
74Glutathione metabolism_Homo sapiens_hsa004800.50098928
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49042316
76Phenylalanine metabolism_Homo sapiens_hsa003600.48150984
77Regulation of autophagy_Homo sapiens_hsa041400.47352856
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46805132
79Selenocompound metabolism_Homo sapiens_hsa004500.46466512
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.44123784
81Base excision repair_Homo sapiens_hsa034100.43736139
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.42680144
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39913662
84Folate biosynthesis_Homo sapiens_hsa007900.38332334
85Carbon metabolism_Homo sapiens_hsa012000.37430820
86ABC transporters_Homo sapiens_hsa020100.36940207
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36700658
88Sulfur metabolism_Homo sapiens_hsa009200.36618335
89beta-Alanine metabolism_Homo sapiens_hsa004100.35562473
90Spliceosome_Homo sapiens_hsa030400.34972850
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32959381
92Homologous recombination_Homo sapiens_hsa034400.28103134
93Circadian rhythm_Homo sapiens_hsa047100.26795773
94Fatty acid metabolism_Homo sapiens_hsa012120.26308951
95Nucleotide excision repair_Homo sapiens_hsa034200.24912822
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23877940
97Herpes simplex infection_Homo sapiens_hsa051680.23085771
98Starch and sucrose metabolism_Homo sapiens_hsa005000.22971130
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.21044852
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.19324170

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »