BDNF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane organization (GO:0097090)6.79715812
2presynaptic membrane assembly (GO:0097105)6.48730519
3skin morphogenesis (GO:0043589)5.58140420
4collagen fibril organization (GO:0030199)5.54410516
5kidney mesenchyme development (GO:0072074)5.20306352
6neuron cell-cell adhesion (GO:0007158)5.18522133
7vocalization behavior (GO:0071625)5.09389903
8protein localization to synapse (GO:0035418)5.08845208
9cell adhesion mediated by integrin (GO:0033627)5.07782529
10chondrocyte proliferation (GO:0035988)5.02903416
11synaptic vesicle exocytosis (GO:0016079)4.92976156
12protein heterotrimerization (GO:0070208)4.92938905
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.81143328
14endocardial cushion development (GO:0003197)4.77597734
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.76619253
16glutamate receptor signaling pathway (GO:0007215)4.70547955
17endodermal cell differentiation (GO:0035987)4.53275509
18bone trabecula formation (GO:0060346)4.47403350
19positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.46901593
20* glutamate secretion (GO:0014047)4.43867446
21synaptic vesicle docking involved in exocytosis (GO:0016081)4.42882908
22type B pancreatic cell proliferation (GO:0044342)4.40288657
23regulation of synaptic vesicle exocytosis (GO:2000300)4.30813697
24* regulation of short-term neuronal synaptic plasticity (GO:0048172)4.27312013
25postsynaptic membrane organization (GO:0001941)4.27142885
26regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.23712998
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.22523717
28synaptic transmission, glutamatergic (GO:0035249)4.22049216
29substrate-dependent cell migration (GO:0006929)4.20442003
30cellular response to vitamin (GO:0071295)4.15417465
31metanephric mesenchyme development (GO:0072075)4.12240052
32neuron-neuron synaptic transmission (GO:0007270)4.10526721
33mesenchymal-epithelial cell signaling (GO:0060638)4.09794028
34regulation of glutamate receptor signaling pathway (GO:1900449)4.04960598
35neurotransmitter-gated ion channel clustering (GO:0072578)4.03707971
36mesodermal cell differentiation (GO:0048333)3.93279199
37pericardium development (GO:0060039)3.80197186
38cell migration involved in heart development (GO:0060973)3.79873412
39regulation of synaptic vesicle transport (GO:1902803)3.77430323
40G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.75277297
41cellular response to vitamin D (GO:0071305)3.75243923
42positive regulation of synapse maturation (GO:0090129)3.74765994
43* gamma-aminobutyric acid signaling pathway (GO:0007214)3.74296702
44protein retention in ER lumen (GO:0006621)3.72783560
45cell migration involved in sprouting angiogenesis (GO:0002042)3.71489731
46* neuron recognition (GO:0008038)3.70853212
47extracellular matrix assembly (GO:0085029)3.68775289
48response to histamine (GO:0034776)3.67831855
49* regulation of excitatory postsynaptic membrane potential (GO:0060079)3.67615167
50maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.65895976
51* regulation of postsynaptic membrane potential (GO:0060078)3.65010459
52neuronal action potential propagation (GO:0019227)3.64998942
53* negative regulation of synaptic transmission, GABAergic (GO:0032229)3.64178610
54endothelial cell morphogenesis (GO:0001886)3.62945824
55membrane assembly (GO:0071709)3.62649952
56locomotory exploration behavior (GO:0035641)3.61741996
57regulation of vesicle fusion (GO:0031338)3.56463454
58long-term synaptic potentiation (GO:0060291)3.55780844
59cerebellar granule cell differentiation (GO:0021707)3.54657973
60positive regulation of blood vessel endothelial cell migration (GO:0043536)3.54583340
61* positive regulation of synapse assembly (GO:0051965)3.52964101
62axonal fasciculation (GO:0007413)3.52287365
63positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.50203712
64heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.50112253
65regulation of glutamate secretion (GO:0014048)3.49558312
66behavioral response to cocaine (GO:0048148)3.46666465
67actin filament depolymerization (GO:0030042)3.43899510
68positive regulation of fibroblast migration (GO:0010763)3.42574929
69* regulation of long-term neuronal synaptic plasticity (GO:0048169)3.40418431
70synaptic vesicle endocytosis (GO:0048488)3.37138723
71* behavioral defense response (GO:0002209)3.36296727
72* behavioral fear response (GO:0001662)3.36296727
73regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.36238588
74exploration behavior (GO:0035640)3.34803512
75synaptic vesicle maturation (GO:0016188)3.34379722
76Golgi transport vesicle coating (GO:0048200)3.34253809
77COPI coating of Golgi vesicle (GO:0048205)3.34253809
78positive regulation of neurotransmitter secretion (GO:0001956)3.32234772
79righting reflex (GO:0060013)3.30356477
80* fear response (GO:0042596)3.30026384
81regulation of synaptic transmission, glutamatergic (GO:0051966)3.29127414
82negative regulation of axon extension involved in axon guidance (GO:0048843)3.28265469
83regulation of synapse maturation (GO:0090128)3.26996228
84negative regulation of smooth muscle cell migration (GO:0014912)3.23880198
85* regulation of neuronal synaptic plasticity (GO:0048168)3.23645255
86regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.21980118
87negative regulation of chondrocyte differentiation (GO:0032331)3.19622813
88* regulation of synapse assembly (GO:0051963)3.19061361
89cell-substrate junction assembly (GO:0007044)3.18927673
90wound healing, spreading of epidermal cells (GO:0035313)3.18590979
91hypotonic response (GO:0006971)3.18076241
92collagen metabolic process (GO:0032963)3.16844942
93positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.16829274
94negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.14863435
95* regulation of synaptic plasticity (GO:0048167)3.13448917
96neurotransmitter secretion (GO:0007269)3.12041477
97negative regulation of osteoblast proliferation (GO:0033689)3.08180280
98paraxial mesoderm development (GO:0048339)3.07932662
99innervation (GO:0060384)3.07825084
100dermatan sulfate biosynthetic process (GO:0030208)3.07679655
101extracellular fibril organization (GO:0043206)3.07394115
102positive regulation of endothelial cell apoptotic process (GO:2000353)3.07347782
103negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.06463060
104protein hydroxylation (GO:0018126)3.04598305
105substrate adhesion-dependent cell spreading (GO:0034446)3.04592239
106regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.01505245
107positive regulation of membrane potential (GO:0045838)3.00656901
108regulation of neurotransmitter secretion (GO:0046928)2.99015220
109regulation of dendritic spine morphogenesis (GO:0061001)2.98765594
110transmission of nerve impulse (GO:0019226)2.98470419
111cochlea development (GO:0090102)2.98085876
112positive regulation of osteoblast proliferation (GO:0033690)2.97988721
113protein localization to endosome (GO:0036010)2.97131925
114positive regulation of synaptic transmission, GABAergic (GO:0032230)2.97043359
115positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.95690814
116adhesion of symbiont to host cell (GO:0044650)2.93734937
117virion attachment to host cell (GO:0019062)2.93734937
118* regulation of synapse organization (GO:0050807)2.91507288
119muscle cell migration (GO:0014812)2.91253845
120multicellular organismal macromolecule metabolic process (GO:0044259)2.91090290
121regulation of axon regeneration (GO:0048679)2.91075480
122regulation of neuron projection regeneration (GO:0070570)2.91075480
123collagen catabolic process (GO:0030574)2.90442397
124planar cell polarity pathway involved in neural tube closure (GO:0090179)2.90422544
125sprouting angiogenesis (GO:0002040)2.90198132
126transferrin transport (GO:0033572)2.90052194
127peptidyl-proline hydroxylation (GO:0019511)2.89673187
128positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.89632062
129dermatan sulfate metabolic process (GO:0030205)2.89311344
130positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.88792404
131synapse assembly (GO:0007416)2.88444094
132cell-substrate adherens junction assembly (GO:0007045)2.87773782
133focal adhesion assembly (GO:0048041)2.87773782
134regulation of dendritic spine development (GO:0060998)2.87717182
135basement membrane organization (GO:0071711)2.87403172
136protein localization to cell surface (GO:0034394)2.86637141
137retina vasculature morphogenesis in camera-type eye (GO:0061299)2.86262850
138female mating behavior (GO:0060180)2.86156971
139dendritic spine morphogenesis (GO:0060997)2.84967036
140smooth muscle tissue development (GO:0048745)2.84815792
141regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.84494542
142adherens junction assembly (GO:0034333)2.84443594
143positive regulation of synaptic transmission (GO:0050806)2.83977327
144* membrane depolarization (GO:0051899)2.83534464
145positive regulation of axon extension (GO:0045773)2.83518322
146lymphangiogenesis (GO:0001946)2.83074970
147ATP hydrolysis coupled proton transport (GO:0015991)2.82873930
148energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.82873930
149negative regulation of fatty acid transport (GO:2000192)2.81144269
150heparan sulfate proteoglycan metabolic process (GO:0030201)2.80174410
151learning (GO:0007612)2.79127319
152barbed-end actin filament capping (GO:0051016)2.79025403
153dopamine transport (GO:0015872)2.77983714
154negative regulation of embryonic development (GO:0045992)2.77382605
155neurotransmitter transport (GO:0006836)2.77098599
156wound healing, spreading of cells (GO:0044319)2.77010434
157sequestering of extracellular ligand from receptor (GO:0035581)2.75792008
158long-term memory (GO:0007616)2.75472358
159regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.75057789
160synaptic transmission (GO:0007268)2.74871404
161stress fiber assembly (GO:0043149)2.74834402
162dendritic spine organization (GO:0097061)2.74387568
163trivalent inorganic cation transport (GO:0072512)2.73923662
164ferric iron transport (GO:0015682)2.73923662
165regulation of plasminogen activation (GO:0010755)2.73896537
166multicellular organismal metabolic process (GO:0044236)2.73884147
167negative regulation of nitric-oxide synthase activity (GO:0051001)2.73871298
168dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.73850048
169synaptic vesicle transport (GO:0048489)2.73712037
170establishment of synaptic vesicle localization (GO:0097480)2.73712037
171positive regulation of cartilage development (GO:0061036)2.73612173
172membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.73537749
173proline transport (GO:0015824)2.73224646
174positive regulation of neurotransmitter transport (GO:0051590)2.72858842
175regulation of osteoblast proliferation (GO:0033688)2.71443720
176regulation of female receptivity (GO:0045924)2.70804559
177startle response (GO:0001964)2.70555518
178regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.70325558
179negative regulation of dendrite morphogenesis (GO:0050774)2.70189287
180regulation of axon extension involved in axon guidance (GO:0048841)2.69271126
181regulation of neurotransmitter transport (GO:0051588)2.68830256
182cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.68313949
183extracellular regulation of signal transduction (GO:1900115)2.68091002
184extracellular negative regulation of signal transduction (GO:1900116)2.68091002
185negative regulation of BMP signaling pathway (GO:0030514)2.67379654
186chondrocyte development (GO:0002063)2.67090035
187blood vessel endothelial cell migration (GO:0043534)2.66997687
188lung vasculature development (GO:0060426)2.64911167
189negative regulation of axon guidance (GO:1902668)2.62654866
190vascular endothelial growth factor signaling pathway (GO:0038084)2.62643221
191adhesion of symbiont to host (GO:0044406)2.62071178
192positive regulation of endothelial cell migration (GO:0010595)2.61760168
193apoptotic cell clearance (GO:0043277)2.60998522
194hemidesmosome assembly (GO:0031581)2.60149935
195G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.60004831
196cochlea morphogenesis (GO:0090103)2.58943937
197multicellular organismal catabolic process (GO:0044243)2.58743526
198regulation of integrin-mediated signaling pathway (GO:2001044)2.58390508

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.41658205
2GBX2_23144817_ChIP-Seq_PC3_Human4.61343654
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.47809792
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.88262231
5BRD4_25478319_ChIP-Seq_HGPS_Human3.73673809
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.11237955
7* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.06972008
8* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.92714650
9CJUN_26792858_Chip-Seq_BT549_Human2.91021379
10RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.82426205
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.76116953
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.67874462
13* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.62199636
14TAF15_26573619_Chip-Seq_HEK293_Human2.61332362
15CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.61302745
16EP300_21415370_ChIP-Seq_HL-1_Mouse2.58151809
17* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.56579754
18* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.56579754
19SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.55315541
20* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.52282845
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.51310804
22* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.49319334
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.42637291
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.42047445
25ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.33478484
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.28708974
27* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.23191548
28TP63_17297297_ChIP-ChIP_HaCaT_Human2.22539976
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.16970120
30* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.16172082
31CLOCK_20551151_ChIP-Seq_293T_Human2.14004237
32SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.12465725
33SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.12465725
34CTBP1_25329375_ChIP-Seq_LNCAP_Human2.12007233
35* REST_21632747_ChIP-Seq_MESCs_Mouse2.03767105
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03309491
37* RNF2_27304074_Chip-Seq_ESCs_Mouse2.01977530
38WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.00737425
39P300_19829295_ChIP-Seq_ESCs_Human1.98339693
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.95766312
41* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.94948192
42* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.93765431
43* SMAD4_21799915_ChIP-Seq_A2780_Human1.92668082
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91129722
45TP53_22127205_ChIP-Seq_IMR90_Human1.91032274
46* EZH2_27294783_Chip-Seq_ESCs_Mouse1.89892161
47MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.89307194
48SUZ12_27294783_Chip-Seq_ESCs_Mouse1.89100018
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87359440
50JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.86467159
51CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.85236050
52VDR_22108803_ChIP-Seq_LS180_Human1.84673998
53IGF1R_20145208_ChIP-Seq_DFB_Human1.83015877
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82538449
55FUS_26573619_Chip-Seq_HEK293_Human1.82477366
56JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.76375533
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75861639
58ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.75662788
59* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.74347852
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.74260032
61ZNF274_21170338_ChIP-Seq_K562_Hela1.73602837
62HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.72649814
63NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.71894109
64* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.67314049
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.66963056
66PPAR_26484153_Chip-Seq_NCI-H1993_Human1.64990041
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63014827
68HIF1A_21447827_ChIP-Seq_MCF-7_Human1.60357027
69P300_27058665_Chip-Seq_ZR-75-30cells_Human1.59839749
70DROSHA_22980978_ChIP-Seq_HELA_Human1.58174807
71AR_21909140_ChIP-Seq_LNCAP_Human1.57747648
72CBX2_27304074_Chip-Seq_ESCs_Mouse1.56870719
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.56625110
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.56589720
75* SMAD_19615063_ChIP-ChIP_OVARY_Human1.55508127
76TP53_18474530_ChIP-ChIP_U2OS_Human1.55052454
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.54404837
78RARB_27405468_Chip-Seq_BRAIN_Mouse1.54052041
79AR_21572438_ChIP-Seq_LNCaP_Human1.53056636
80SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.50804103
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49522112
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48581116
83EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.47174981
84SMC1_22415368_ChIP-Seq_MEFs_Mouse1.47164822
85* UBF1/2_26484160_Chip-Seq_HMECs_Human1.46871274
86* ELK3_25401928_ChIP-Seq_HUVEC_Human1.46258063
87* REST_18959480_ChIP-ChIP_MESCs_Mouse1.45593853
88SALL4_18804426_ChIP-ChIP_XEN_Mouse1.45404901
89AR_25329375_ChIP-Seq_VCAP_Human1.45124125
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44405281
91RNF2_27304074_Chip-Seq_NSC_Mouse1.41405254
92KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40907825
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39611051
94JUN_21703547_ChIP-Seq_K562_Human1.38775487
95* SA1_22415368_ChIP-Seq_MEFs_Mouse1.37539173
96NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34898852
97SOX9_24532713_ChIP-Seq_HFSC_Mouse1.33954480
98* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.33760907
99POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33242553
100GATA2_21666600_ChIP-Seq_HMVEC_Human1.33230243
101TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.32910915
102NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.32760929
103TP53_16413492_ChIP-PET_HCT116_Human1.32368007
104* TP53_23651856_ChIP-Seq_MEFs_Mouse1.29549040
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29545245
106ER_23166858_ChIP-Seq_MCF-7_Human1.28218759
107CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26308359
108CTNNB1_20460455_ChIP-Seq_HCT116_Human1.25818414
109NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24542367
110NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24542367
111TRIM28_21343339_ChIP-Seq_HEK293_Human1.24293227
112RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21183941
113SOX2_21211035_ChIP-Seq_LN229_Gbm1.19869362
114PRDM14_20953172_ChIP-Seq_ESCs_Human1.19724692
115* STAT3_23295773_ChIP-Seq_U87_Human1.19051476
116WT1_19549856_ChIP-ChIP_CCG9911_Human1.18367572
117TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17251658
118ARNT_22903824_ChIP-Seq_MCF-7_Human1.17233205
119* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16984104
120* NANOG_18555785_Chip-Seq_ESCs_Mouse1.16628395
121EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.16440709
122ATF3_27146783_Chip-Seq_COLON_Human1.14921378
123TCF4_23295773_ChIP-Seq_U87_Human1.14857478
124BCAT_22108803_ChIP-Seq_LS180_Human1.13134078
125RUNX2_22187159_ChIP-Seq_PCA_Human1.12800062
126CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11878157
127ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11184216
128ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10852243
129EWS_26573619_Chip-Seq_HEK293_Human1.10761413
130NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09917999
131SMC3_22415368_ChIP-Seq_MEFs_Mouse1.09851325
132NFI_21473784_ChIP-Seq_ESCs_Mouse1.09177835
133* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08887865
134* PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human1.06602205
135NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06308382
136TP53_20018659_ChIP-ChIP_R1E_Mouse1.05628480
137RING1B_27294783_Chip-Seq_ESCs_Mouse1.04949312
138* E2F1_18555785_Chip-Seq_ESCs_Mouse1.03249029
139BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02362587
140YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01756356
141SALL1_21062744_ChIP-ChIP_HESCs_Human1.01744468
142AHR_22903824_ChIP-Seq_MCF-7_Human1.01202082
143UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01082507
144DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01003567
145* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00054488
146KDM2B_26808549_Chip-Seq_REH_Human0.99847122
147FLI1_27457419_Chip-Seq_LIVER_Mouse0.99714439
148PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99534373
149ISL1_27105846_Chip-Seq_CPCs_Mouse0.98924489
150RXR_22108803_ChIP-Seq_LS180_Human0.98034693
151TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97704856
152* P53_22387025_ChIP-Seq_ESCs_Mouse0.97353560
153MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96852131
154TBX3_20139965_ChIP-Seq_ESCs_Mouse0.95985919
155SOX9_26525672_Chip-Seq_HEART_Mouse0.95374661
156TBX3_20139965_ChIP-Seq_MESCs_Mouse0.95225862
157FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95146488
158AR_19668381_ChIP-Seq_PC3_Human0.94813754
159ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.94694729
160PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.94304953
161FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93054595
162SOX17_20123909_ChIP-Seq_XEN_Mouse0.92754143
163EGR1_19374776_ChIP-ChIP_THP-1_Human0.92436618
164* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90023302
165HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88180426
166TBX20_22328084_ChIP-Seq_HEART_Mouse0.87932850

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern6.09478868
2* MP0004859_abnormal_synaptic_plasticity4.84222984
3MP0003705_abnormal_hypodermis_morpholog4.35548251
4MP0003279_aneurysm3.71882548
5MP0001968_abnormal_touch/_nociception3.70677085
6MP0002736_abnormal_nociception_after3.63346696
7* MP0003635_abnormal_synaptic_transmissio3.62676407
8MP0005257_abnormal_intraocular_pressure3.58911032
9MP0005275_abnormal_skin_tensile3.34273238
10MP0001958_emphysema3.32434618
11* MP0009745_abnormal_behavioral_response3.21593134
12MP0004270_analgesia3.08748508
13* MP0002063_abnormal_learning/memory/cond2.99248208
14MP0002735_abnormal_chemical_nociception2.93279450
15MP0003950_abnormal_plasma_membrane2.86688063
16MP0003566_abnormal_cell_adhesion2.86482319
17MP0010368_abnormal_lymphatic_system2.76835623
18MP0001188_hyperpigmentation2.72013298
19MP0009384_cardiac_valve_regurgitation2.71592480
20MP0006276_abnormal_autonomic_nervous2.71337655
21* MP0002064_seizures2.70934792
22MP0009046_muscle_twitch2.58511044
23* MP0002572_abnormal_emotion/affect_behav2.58042130
24MP0001542_abnormal_bone_strength2.53705866
25* MP0001440_abnormal_grooming_behavior2.34118806
26MP0002272_abnormal_nervous_system2.28430762
27MP0002734_abnormal_mechanical_nocicepti2.27489523
28MP0003091_abnormal_cell_migration2.19980436
29MP0001501_abnormal_sleep_pattern2.19971071
30MP0006054_spinal_hemorrhage2.10394646
31MP0001486_abnormal_startle_reflex2.07473357
32MP0005171_absent_coat_pigmentation2.05950793
33MP0010352_gastrointestinal_tract_polyps1.97904308
34MP0003941_abnormal_skin_development1.97142427
35* MP0002067_abnormal_sensory_capabilities1.95482484
36MP0009780_abnormal_chondrocyte_physiolo1.91232334
37MP0005023_abnormal_wound_healing1.89004140
38MP0002184_abnormal_innervation1.86368483
39MP0002733_abnormal_thermal_nociception1.86046321
40MP0000767_abnormal_smooth_muscle1.85314853
41MP0001970_abnormal_pain_threshold1.83849260
42MP0002837_dystrophic_cardiac_calcinosis1.82946681
43MP0001905_abnormal_dopamine_level1.77617505
44MP0000778_abnormal_nervous_system1.76763074
45MP0010030_abnormal_orbit_morphology1.76179204
46MP0000534_abnormal_ureter_morphology1.74179780
47MP0002877_abnormal_melanocyte_morpholog1.70976652
48MP0003879_abnormal_hair_cell1.69201657
49MP0009379_abnormal_foot_pigmentation1.67877060
50MP0005508_abnormal_skeleton_morphology1.63090201
51MP0005386_behavior/neurological_phenoty1.55296197
52MP0004924_abnormal_behavior1.55296197
53MP0003942_abnormal_urinary_system1.54159375
54MP0002060_abnormal_skin_morphology1.53626188
55MP0001529_abnormal_vocalization1.53026977
56MP0002876_abnormal_thyroid_physiology1.49857211
57* MP0002557_abnormal_social/conspecific_i1.47489009
58MP0009053_abnormal_anal_canal1.40685909
59MP0005623_abnormal_meninges_morphology1.40017981
60MP0001243_abnormal_dermal_layer1.35878522
61MP0001502_abnormal_circadian_rhythm1.35770388
62MP0002896_abnormal_bone_mineralization1.35184684
63MP0004145_abnormal_muscle_electrophysio1.34399370
64* MP0004811_abnormal_neuron_physiology1.30124240
65MP0000733_abnormal_muscle_development1.30106978
66MP0001879_abnormal_lymphatic_vessel1.27194145
67MP0010386_abnormal_urinary_bladder1.25911740
68MP0005423_abnormal_somatic_nervous1.25724718
69MP0003122_maternal_imprinting1.24078983
70MP0001984_abnormal_olfaction1.22223317
71MP0004742_abnormal_vestibular_system1.20851849
72MP0004484_altered_response_of1.20404652
73MP0000428_abnormal_craniofacial_morphol1.20103098
74* MP0002882_abnormal_neuron_morphology1.18075284
75MP0003329_amyloid_beta_deposits1.17774268
76MP0004142_abnormal_muscle_tone1.17277140
77* MP0002066_abnormal_motor_capabilities/c1.15006345
78MP0005646_abnormal_pituitary_gland1.13358451
79MP0000751_myopathy1.11864522
80MP0002108_abnormal_muscle_morphology1.11765152
81MP0000955_abnormal_spinal_cord1.07760184
82MP0004858_abnormal_nervous_system1.06489478
83MP0005503_abnormal_tendon_morphology1.05378622
84MP0005197_abnormal_uvea_morphology1.05319310
85MP0008569_lethality_at_weaning1.05214784
86MP0003755_abnormal_palate_morphology1.03815694
87MP0006292_abnormal_olfactory_placode1.03764982
88MP0005595_abnormal_vascular_smooth0.99210124
89MP0004134_abnormal_chest_morphology0.97795149
90MP0000003_abnormal_adipose_tissue0.97100189
91MP0000759_abnormal_skeletal_muscle0.94619809
92MP0008004_abnormal_stomach_pH0.94554220
93MP0005409_darkened_coat_color0.93694205
94MP0003787_abnormal_imprinting0.89894799
95MP0001664_abnormal_digestion0.89406387
96MP0000013_abnormal_adipose_tissue0.88229445
97MP0003937_abnormal_limbs/digits/tail_de0.86651369
98MP0004085_abnormal_heartbeat0.85523708
99MP0002128_abnormal_blood_circulation0.85394541
100* MP0000762_abnormal_tongue_morphology0.85290430
101MP0005551_abnormal_eye_electrophysiolog0.83099120
102MP0005164_abnormal_response_to0.82743891
103MP0003448_altered_tumor_morphology0.82505866
104MP0001849_ear_inflammation0.80512811
105MP0000015_abnormal_ear_pigmentation0.80503201
106MP0000163_abnormal_cartilage_morphology0.80234062
107* MP0002152_abnormal_brain_morphology0.80043484
108MP0000049_abnormal_middle_ear0.79005467
109* MP0001963_abnormal_hearing_physiology0.78313172
110MP0003935_abnormal_craniofacial_develop0.77801939
111* MP0003633_abnormal_nervous_system0.77305281
112MP0009697_abnormal_copulation0.76993365
113MP0004084_abnormal_cardiac_muscle0.76415777
114* MP0000432_abnormal_head_morphology0.75968154
115MP0008438_abnormal_cutaneous_collagen0.75474282
116MP0003283_abnormal_digestive_organ0.75413754
117MP0009250_abnormal_appendicular_skeleto0.75352342
118MP0005645_abnormal_hypothalamus_physiol0.74677995
119MP0000749_muscle_degeneration0.73812600
120MP0000538_abnormal_urinary_bladder0.72932976
121MP0008874_decreased_physiological_sensi0.72811875
122* MP0002069_abnormal_eating/drinking_beha0.72777842
123MP0004215_abnormal_myocardial_fiber0.72264039
124MP0005193_abnormal_anterior_eye0.72022154
125MP0000631_abnormal_neuroendocrine_gland0.71978155
126MP0000462_abnormal_digestive_system0.71626127
127MP0005390_skeleton_phenotype0.71387343
128* MP0002752_abnormal_somatic_nervous0.70996937
129* MP0002751_abnormal_autonomic_nervous0.70815107
130MP0000750_abnormal_muscle_regeneration0.70812961
131MP0003385_abnormal_body_wall0.70412730
132MP0002114_abnormal_axial_skeleton0.70283696
133MP0002295_abnormal_pulmonary_circulatio0.70234137
134MP0002115_abnormal_skeleton_extremities0.70121070
135MP0005535_abnormal_body_temperature0.69753233
136MP0001614_abnormal_blood_vessel0.69362083
137MP0002113_abnormal_skeleton_development0.69118458
138MP0002932_abnormal_joint_morphology0.69105217
139MP0001177_atelectasis0.68850489
140MP0001299_abnormal_eye_distance/0.67451830
141MP0001915_intracranial_hemorrhage0.66841847
142MP0001485_abnormal_pinna_reflex0.66601518
143* MP0000026_abnormal_inner_ear0.66539851
144MP0002282_abnormal_trachea_morphology0.65326217
145* MP0003631_nervous_system_phenotype0.64549236
146MP0005394_taste/olfaction_phenotype0.64348874
147MP0005499_abnormal_olfactory_system0.64348874
148MP0002909_abnormal_adrenal_gland0.64134947
149MP0000681_abnormal_thyroid_gland0.63781178
150MP0004272_abnormal_basement_membrane0.63250103
151MP0002116_abnormal_craniofacial_bone0.62256776
152MP0002168_other_aberrant_phenotype0.61852442
153MP0005621_abnormal_cell_physiology0.61851115
154MP0000569_abnormal_digit_pigmentation0.60951460
155MP0000537_abnormal_urethra_morphology0.60689045
156MP0001348_abnormal_lacrimal_gland0.60276885
157MP0002822_catalepsy0.59682822
158MP0005084_abnormal_gallbladder_morpholo0.59267896
159MP0002177_abnormal_outer_ear0.58651350
160MP0002925_abnormal_cardiovascular_devel0.58385548
161MP0002229_neurodegeneration0.57764792
162MP0004233_abnormal_muscle_weight0.57029913
163MP0004087_abnormal_muscle_fiber0.56936049
164MP0002269_muscular_atrophy0.56354386
165MP0008872_abnormal_physiological_respon0.56339263
166MP0005620_abnormal_muscle_contractility0.55139689
167MP0002133_abnormal_respiratory_system0.54669173
168MP0005388_respiratory_system_phenotype0.54669173
169MP0002332_abnormal_exercise_endurance0.54302611
170MP0001175_abnormal_lung_morphology0.53439661
171MP0002109_abnormal_limb_morphology0.53375169
172MP0006138_congestive_heart_failure0.53272697
173MP0005187_abnormal_penis_morphology0.52187521
174MP0002697_abnormal_eye_size0.52166599
175MP0005165_increased_susceptibility_to0.51186041
176MP0002084_abnormal_developmental_patter0.51127248
177MP0002233_abnormal_nose_morphology0.50344745
178MP0008932_abnormal_embryonic_tissue0.50249425
179MP0002085_abnormal_embryonic_tissue0.50125039
180MP0004036_abnormal_muscle_relaxation0.49057497

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.97875648
2Aortic dissection (HP:0002647)5.54507541
3Epileptic encephalopathy (HP:0200134)5.38069679
4Atonic seizures (HP:0010819)5.35537138
5Focal seizures (HP:0007359)5.09544211
6Aortic aneurysm (HP:0004942)5.03393014
7Vascular tortuosity (HP:0004948)4.87114975
8Ankle contracture (HP:0006466)4.55457322
9Soft skin (HP:0000977)4.50405115
10Arterial tortuosity (HP:0005116)4.47970929
11Febrile seizures (HP:0002373)4.46919129
12Hyperventilation (HP:0002883)4.46395494
13Bladder diverticulum (HP:0000015)4.13065012
14Absence seizures (HP:0002121)4.06581266
15Follicular hyperkeratosis (HP:0007502)4.06471039
16Visual hallucinations (HP:0002367)4.06061244
17Atrophic scars (HP:0001075)4.04073329
18Dialeptic seizures (HP:0011146)3.95938950
19Type 1 muscle fiber predominance (HP:0003803)3.81451167
20Wormian bones (HP:0002645)3.78777279
21Retinal dysplasia (HP:0007973)3.76102589
22Myokymia (HP:0002411)3.72157333
23Spondylolisthesis (HP:0003302)3.62103252
24Progressive cerebellar ataxia (HP:0002073)3.53299824
25Genu recurvatum (HP:0002816)3.53155106
26Fragile skin (HP:0001030)3.52219221
27Neonatal short-limb short stature (HP:0008921)3.41643033
28Shallow orbits (HP:0000586)3.39469824
29Type II lissencephaly (HP:0007260)3.29873631
30Generalized tonic-clonic seizures (HP:0002069)3.28404056
31Peritonitis (HP:0002586)3.25963933
32Absent speech (HP:0001344)3.14712448
33Buphthalmos (HP:0000557)3.14503790
34Broad metatarsal (HP:0001783)3.14366416
35Broad-based gait (HP:0002136)3.13240353
36Bowel diverticulosis (HP:0005222)3.09818282
37Cervical subluxation (HP:0003308)3.08413318
38Blue sclerae (HP:0000592)3.06573338
39Amblyopia (HP:0000646)3.05965813
40Dilatation of the ascending aorta (HP:0005111)3.01146154
41Mitral valve prolapse (HP:0001634)2.93871220
42Aortic regurgitation (HP:0001659)2.93446240
43Elbow flexion contracture (HP:0002987)2.91135128
44Inability to walk (HP:0002540)2.88391801
45Biconcave vertebral bodies (HP:0004586)2.77327200
46Scanning speech (HP:0002168)2.76328129
47Excessive salivation (HP:0003781)2.70811152
48Drooling (HP:0002307)2.70811152
49Ulnar bowing (HP:0003031)2.67577995
50Mitral regurgitation (HP:0001653)2.65691374
51Joint laxity (HP:0001388)2.64429995
52Hyperextensible skin (HP:0000974)2.63333888
53Gaze-evoked nystagmus (HP:0000640)2.55183454
54Vertebral compression fractures (HP:0002953)2.54647351
55Bradycardia (HP:0001662)2.52128024
56Overgrowth (HP:0001548)2.50016872
57Osteolytic defects of the hand bones (HP:0009699)2.49308184
58Osteolytic defects of the phalanges of the hand (HP:0009771)2.49308184
59Protruding tongue (HP:0010808)2.48445249
60Epileptiform EEG discharges (HP:0011182)2.48385352
61Abnormal delivery (HP:0001787)2.48310340
62Mildly elevated creatine phosphokinase (HP:0008180)2.47436835
63Short nail (HP:0001799)2.44674238
64Limb dystonia (HP:0002451)2.43627258
65Spinal rigidity (HP:0003306)2.43151553
66Wide anterior fontanel (HP:0000260)2.42053710
67Abnormality of the acetabulum (HP:0003170)2.35748534
68Spinal cord lesions (HP:0100561)2.29298331
69Syringomyelia (HP:0003396)2.29298331
70Distal lower limb amyotrophy (HP:0008944)2.28448127
71Coronal craniosynostosis (HP:0004440)2.25087300
72Truncal ataxia (HP:0002078)2.23781401
73Lower limb amyotrophy (HP:0007210)2.22933680
74Heterochromia iridis (HP:0001100)2.22672514
75Knee flexion contracture (HP:0006380)2.22614067
76Aortic valve stenosis (HP:0001650)2.22374608
77Abnormal hair whorl (HP:0010721)2.20006610
78Insidious onset (HP:0003587)2.19708696
79Termporal pattern (HP:0011008)2.19708696
80Gait imbalance (HP:0002141)2.18784625
81Poor eye contact (HP:0000817)2.18769938
82Acute necrotizing encephalopathy (HP:0006965)2.18012515
83Congenital glaucoma (HP:0001087)2.17789894
84Dysdiadochokinesis (HP:0002075)2.16895386
85Renal duplication (HP:0000075)2.16852118
86Round ear (HP:0100830)2.16564872
87Increased variability in muscle fiber diameter (HP:0003557)2.15825601
88Impaired vibration sensation in the lower limbs (HP:0002166)2.15150672
89Absent frontal sinuses (HP:0002688)2.14876045
90Disproportionate tall stature (HP:0001519)2.13063655
91Long toe (HP:0010511)2.12883003
92Mitral stenosis (HP:0001718)2.12056044
93Anxiety (HP:0000739)2.11600223
94Aneurysm (HP:0002617)2.11480500
95EEG with generalized epileptiform discharges (HP:0011198)2.10432198
96Entropion (HP:0000621)2.09845328
97Distal upper limb amyotrophy (HP:0007149)2.08981880
98Upper limb amyotrophy (HP:0009129)2.08981880
99Cerebral aneurysm (HP:0004944)2.07894986
100Cardiovascular calcification (HP:0011915)2.07869525
101Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.07585414
102Ectopia lentis (HP:0001083)2.07413984
103Mild short stature (HP:0003502)2.06766188
104Abnormality of salivation (HP:0100755)2.06373915
105Cerebellar dysplasia (HP:0007033)2.06121433
106Premature rupture of membranes (HP:0001788)2.05839490
107Mesomelia (HP:0003027)2.05473329
108Narrow nasal bridge (HP:0000446)2.02945169
109Wrist flexion contracture (HP:0001239)2.01655056
110Delayed gross motor development (HP:0002194)2.01049171
111Medial flaring of the eyebrow (HP:0010747)2.00453500
112Deviation of the hallux (HP:0010051)1.99026664
113Pheochromocytoma (HP:0002666)1.98990935
114Dysmetria (HP:0001310)1.97725092
115Congenital primary aphakia (HP:0007707)1.97506007
116Nonimmune hydrops fetalis (HP:0001790)1.97371338
117Breech presentation (HP:0001623)1.97119272
118Achilles tendon contracture (HP:0001771)1.96565870
119Camptodactyly of toe (HP:0001836)1.96266461
120Progressive macrocephaly (HP:0004481)1.96233146
121Fetal akinesia sequence (HP:0001989)1.95252428
122Limb-girdle muscle weakness (HP:0003325)1.95144794
123Abnormality of dentin (HP:0010299)1.94657619
124Difficulty climbing stairs (HP:0003551)1.94239277
125Palpebral edema (HP:0100540)1.94108916
126Hallux valgus (HP:0001822)1.93682504
127Hydroureter (HP:0000072)1.93057560
128Flat cornea (HP:0007720)1.92103942
129Protruding ear (HP:0000411)1.90527220
130Generalized amyotrophy (HP:0003700)1.89741537
131Abnormal mitochondria in muscle tissue (HP:0008316)1.89473702
132Abnormality of skeletal muscle fiber size (HP:0012084)1.86984555
133Lissencephaly (HP:0001339)1.86147082
134Protrusio acetabuli (HP:0003179)1.86127981
135Reduced subcutaneous adipose tissue (HP:0003758)1.85099947
136Bowing of the arm (HP:0006488)1.84453256
137Bowed forearm bones (HP:0003956)1.84453256
138Abnormality of the fetal cardiovascular system (HP:0010948)1.84063158
139Abnormal umbilical cord blood vessels (HP:0011403)1.84063158
140Single umbilical artery (HP:0001195)1.84063158
141Aplasia/Hypoplasia of the lens (HP:0008063)1.83703922
142Slender build (HP:0001533)1.82635854
143Delusions (HP:0000746)1.82563153
144Cerebral inclusion bodies (HP:0100314)1.82164555
145Neuroendocrine neoplasm (HP:0100634)1.81355546
146Incomplete penetrance (HP:0003829)1.80670276
147Joint stiffness (HP:0001387)1.80099667
148Hypsarrhythmia (HP:0002521)1.80052446
149Inguinal hernia (HP:0000023)1.79966367
150Spinal cord compression (HP:0002176)1.79695314
151Blue irides (HP:0000635)1.79290168
152Depression (HP:0000716)1.78744826
153Nephrogenic diabetes insipidus (HP:0009806)1.78637185
154Urinary bladder sphincter dysfunction (HP:0002839)1.78334434
155Genetic anticipation (HP:0003743)1.78269646
156Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.76178309
157Abnormality of the calf musculature (HP:0001430)1.75656688
158Action tremor (HP:0002345)1.75074779
159Broad ribs (HP:0000885)1.75023960
160Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.73616784
161* Hypoventilation (HP:0002791)1.72873212
162Abnormality of the umbilical cord (HP:0010881)1.72799457
163Fair hair (HP:0002286)1.72745957
164Mitochondrial inheritance (HP:0001427)1.72654907
165Natal tooth (HP:0000695)1.72615423
166Morphological abnormality of the middle ear (HP:0008609)1.72233750
167Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.72063544
168Degeneration of the lateral corticospinal tracts (HP:0002314)1.72063544
169Open mouth (HP:0000194)1.71705266
170Impaired social interactions (HP:0000735)1.71174414
171Abnormal social behavior (HP:0012433)1.71174414
172Anterior segment dysgenesis (HP:0007700)1.70142684
173Femoral bowing (HP:0002980)1.69085771
174Increased connective tissue (HP:0009025)1.68754494
175Oligomenorrhea (HP:0000876)1.68515563
176Generalized myoclonic seizures (HP:0002123)1.68193401
177Esotropia (HP:0000565)1.68190879
178Abnormality of the corticospinal tract (HP:0002492)1.64522240
179Poor suck (HP:0002033)1.64220678
180Bradykinesia (HP:0002067)1.64218104
181Dynein arm defect of respiratory motile cilia (HP:0012255)1.63961554
182Absent/shortened dynein arms (HP:0200106)1.63961554
183Failure to thrive in infancy (HP:0001531)1.63401131
184Lower limb muscle weakness (HP:0007340)1.61924706
185Ankle clonus (HP:0011448)1.61869410
186Sensory axonal neuropathy (HP:0003390)1.61816367
187Aplasia/Hypoplasia of the brainstem (HP:0007362)1.61498634
188Hypoplasia of the brainstem (HP:0002365)1.61498634

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.65994620
2EPHA44.12800422
3NTRK33.96495069
4PDGFRA3.37000131
5TTN3.19967614
6PTK22.94262389
7MAP2K72.93517784
8MAP3K122.88963652
9PLK22.81827448
10PAK22.67036801
11MAP3K42.48494830
12MINK12.47715545
13TESK12.38885661
14NEK92.37451180
15EPHB22.29201333
16MAP3K92.14358823
17MET2.09199306
18LATS12.07083608
19ERBB42.04970804
20RIPK42.01676310
21PNCK1.88645322
22PTK2B1.83125260
23MAP3K131.78753810
24MARK11.72414013
25DAPK21.68534314
26MST1R1.67654991
27ARAF1.65456933
28TNIK1.64395977
29PAK41.63763134
30DAPK11.60078266
31CDK191.58795600
32NME11.58358423
33GRK51.56587457
34FLT31.54563498
35PRPF4B1.54553529
36EPHA21.54352003
37FER1.50235565
38PIK3CG1.49170593
39KSR11.47274449
40TGFBR21.43285991
41PAK61.41524678
42AKT31.40809070
43MAP2K41.39918327
44PRKD21.37219882
45CDK81.34665895
46CAMK2A1.33103318
47SIK31.32055411
48BMPR21.28404949
49PRKCG1.26212984
50TRPM71.25101815
51FES1.24238948
52SIK11.22256035
53LATS21.19261321
54CAMK2B1.17613726
55PRKG21.17482247
56STK381.14523246
57PDGFRB1.11856030
58ABL21.10707553
59SIK21.07468180
60MAPK131.04448707
61CDK51.04102719
62PAK31.03533160
63SCYL21.01889817
64MELK0.99788861
65MYLK0.98048712
66CCNB10.96094178
67NTRK10.95444051
68ERBB30.93124049
69CAMKK10.91741184
70PRKCE0.87333145
71CAMK2D0.87281362
72CAMKK20.86325802
73DDR20.84989947
74ICK0.84223555
75OXSR10.83621814
76CSNK1G20.81588856
77PIM20.81413291
78DMPK0.81208944
79FRK0.80285832
80FGR0.79785327
81MUSK0.79681741
82KSR20.79062826
83ADRBK10.79053699
84GRK70.78615438
85MTOR0.77811959
86CDK180.77502557
87NTRK20.77333154
88RAF10.77273923
89MAPKAPK50.77266518
90CDK140.77265341
91RIPK10.77256097
92SGK20.74736155
93CAMK10.74697872
94WNK10.74629187
95ADRBK20.72177290
96MOS0.71224746
97BRAF0.71217707
98BCR0.71076502
99TAOK20.70991286
100STK30.70538134
101CDK150.69970130
102BUB10.69756137
103SGK4940.67912859
104SGK2230.67912859
105CAMK2G0.66596984
106CDC42BPA0.66017206
107PIK3CA0.63963481
108ERN10.62109092
109LIMK10.61963085
110DAPK30.61297473
111NEK20.60674671
112ROCK20.60484506
113CDK11A0.60266662
114PAK10.59579775
115MAP2K10.55084581
116EPHB10.54667603
117SGK10.53744414
118CSNK1G30.53507478
119GSK3A0.53281258
120MKNK20.52739392
121TRIB30.52594390
122MAP3K30.51219002
123PRKD30.51080584
124NEK60.49324646
125WNK40.46261506
126PBK0.45396959
127DYRK1A0.42994239
128CDK90.42783501
129RET0.41877098
130CLK10.40177193
131ROCK10.38133302
132NEK10.37544050
133MAP3K80.37426775
134PRKG10.36850418
135BRSK10.35633297
136RPS6KA20.35575814
137PLK30.35475975
138AURKB0.35219459
139MAP3K70.34766625
140MAP3K60.34290598
141AURKA0.34288457
142TNK20.34066565
143PRKACA0.33680613
144MAPK120.33123461
145STK160.32704104
146CDK30.31498440
147CDK120.30841729
148GRK60.30790741
149MAP3K50.30546148
150PRKCA0.29978117
151CSNK1G10.29975632
152FGFR10.29536036
153CSNK1A1L0.29170228
154BMX0.28519335
155DYRK1B0.28266597
156MAP2K30.27677123
157UHMK10.27520705
158MARK20.27329562
159STK100.27020122
160STK38L0.26500272
161PKN20.26013216
162PRKCZ0.25044355
163ILK0.24491596

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.43178045
2Synaptic vesicle cycle_Homo sapiens_hsa047213.45977457
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.92258136
4Circadian entrainment_Homo sapiens_hsa047132.67762467
5Collecting duct acid secretion_Homo sapiens_hsa049662.56239218
6Amphetamine addiction_Homo sapiens_hsa050312.55900782
7Long-term potentiation_Homo sapiens_hsa047202.55230576
8Glutamatergic synapse_Homo sapiens_hsa047242.51389768
9Morphine addiction_Homo sapiens_hsa050322.36483090
10GABAergic synapse_Homo sapiens_hsa047272.27460366
11Olfactory transduction_Homo sapiens_hsa047402.25226782
12Proteoglycans in cancer_Homo sapiens_hsa052052.22836963
13Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.19507028
14Dopaminergic synapse_Homo sapiens_hsa047282.14358392
15Hippo signaling pathway_Homo sapiens_hsa043902.11101081
16Salivary secretion_Homo sapiens_hsa049702.06989362
17Taste transduction_Homo sapiens_hsa047422.01513978
18Serotonergic synapse_Homo sapiens_hsa047261.99933877
19Renin secretion_Homo sapiens_hsa049241.99677787
20Adherens junction_Homo sapiens_hsa045201.95303114
21Long-term depression_Homo sapiens_hsa047301.93046165
22Oxidative phosphorylation_Homo sapiens_hsa001901.85401989
23TGF-beta signaling pathway_Homo sapiens_hsa043501.74957156
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.74052217
25Vibrio cholerae infection_Homo sapiens_hsa051101.73849866
26Insulin secretion_Homo sapiens_hsa049111.73409971
27Hedgehog signaling pathway_Homo sapiens_hsa043401.72509654
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.67876647
29Protein digestion and absorption_Homo sapiens_hsa049741.67831440
30Oxytocin signaling pathway_Homo sapiens_hsa049211.67694262
31Cholinergic synapse_Homo sapiens_hsa047251.63319399
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.62232054
33Calcium signaling pathway_Homo sapiens_hsa040201.61305508
34AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.57838716
35Small cell lung cancer_Homo sapiens_hsa052221.57814997
36Gastric acid secretion_Homo sapiens_hsa049711.53473118
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.52793109
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.49873138
39PI3K-Akt signaling pathway_Homo sapiens_hsa041511.48193888
40Bladder cancer_Homo sapiens_hsa052191.46947129
41Alzheimers disease_Homo sapiens_hsa050101.43947785
42Basal cell carcinoma_Homo sapiens_hsa052171.42655798
43Cardiac muscle contraction_Homo sapiens_hsa042601.39627648
44Axon guidance_Homo sapiens_hsa043601.36938820
45MicroRNAs in cancer_Homo sapiens_hsa052061.34857318
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.34230729
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.33182831
48Gap junction_Homo sapiens_hsa045401.30073740
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.29854719
50* Cocaine addiction_Homo sapiens_hsa050301.27238319
51GnRH signaling pathway_Homo sapiens_hsa049121.26329365
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.21853564
53Parkinsons disease_Homo sapiens_hsa050121.18472664
54Pathways in cancer_Homo sapiens_hsa052001.16077691
55p53 signaling pathway_Homo sapiens_hsa041151.15276837
56Central carbon metabolism in cancer_Homo sapiens_hsa052301.14726477
57Tight junction_Homo sapiens_hsa045301.11586508
58Glycosaminoglycan degradation_Homo sapiens_hsa005311.10320229
59Phototransduction_Homo sapiens_hsa047441.08006604
60* cAMP signaling pathway_Homo sapiens_hsa040241.07312969
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06843127
62Vascular smooth muscle contraction_Homo sapiens_hsa042701.03980723
63N-Glycan biosynthesis_Homo sapiens_hsa005101.03136272
64Rheumatoid arthritis_Homo sapiens_hsa053231.02985803
65cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02190253
66Dilated cardiomyopathy_Homo sapiens_hsa054141.00451948
67Chronic myeloid leukemia_Homo sapiens_hsa052200.99655710
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95479866
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92458769
70Estrogen signaling pathway_Homo sapiens_hsa049150.91633710
71Melanogenesis_Homo sapiens_hsa049160.91512310
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90402083
73ErbB signaling pathway_Homo sapiens_hsa040120.90371727
74Glioma_Homo sapiens_hsa052140.87425490
75Huntingtons disease_Homo sapiens_hsa050160.82267722
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.80786508
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79646030
78Thyroid cancer_Homo sapiens_hsa052160.79344352
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.78536079
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78102690
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78084780
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76563825
83Endocytosis_Homo sapiens_hsa041440.76371770
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.76015834
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74830728
86Pancreatic cancer_Homo sapiens_hsa052120.74213016
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73907786
88Nucleotide excision repair_Homo sapiens_hsa034200.72808284
89Prostate cancer_Homo sapiens_hsa052150.72291487
90Phagosome_Homo sapiens_hsa041450.71243859
91Ras signaling pathway_Homo sapiens_hsa040140.67768728
92* MAPK signaling pathway_Homo sapiens_hsa040100.65518315
93African trypanosomiasis_Homo sapiens_hsa051430.65140804
94Melanoma_Homo sapiens_hsa052180.64082984
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62609236
96Protein export_Homo sapiens_hsa030600.62509393
97Sulfur metabolism_Homo sapiens_hsa009200.61576354
98Cell cycle_Homo sapiens_hsa041100.61539430
99Rap1 signaling pathway_Homo sapiens_hsa040150.61494510
100Thyroid hormone synthesis_Homo sapiens_hsa049180.58963215
101Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56401786
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53802618
103Selenocompound metabolism_Homo sapiens_hsa004500.53611695
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53088795
105Pancreatic secretion_Homo sapiens_hsa049720.52814498
106Choline metabolism in cancer_Homo sapiens_hsa052310.52684860
107Pentose phosphate pathway_Homo sapiens_hsa000300.52156989
108Wnt signaling pathway_Homo sapiens_hsa043100.52108407
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51974340
110Oocyte meiosis_Homo sapiens_hsa041140.51706988
111Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50887398
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.50573353
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49692165
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49425530
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46680308
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44205484
117Glucagon signaling pathway_Homo sapiens_hsa049220.43857766
118Galactose metabolism_Homo sapiens_hsa000520.42728302
119Circadian rhythm_Homo sapiens_hsa047100.40481582
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40453305
121Type II diabetes mellitus_Homo sapiens_hsa049300.40328529
122Regulation of autophagy_Homo sapiens_hsa041400.40287816
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37788738
124Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.35794963
125Basal transcription factors_Homo sapiens_hsa030220.35690238
126VEGF signaling pathway_Homo sapiens_hsa043700.35490945
127* Alcoholism_Homo sapiens_hsa050340.34700062
128Malaria_Homo sapiens_hsa051440.32922068
129Folate biosynthesis_Homo sapiens_hsa007900.32653712
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.31259738
131Ovarian steroidogenesis_Homo sapiens_hsa049130.28457681
132* Neurotrophin signaling pathway_Homo sapiens_hsa047220.24737278
133ECM-receptor interaction_Homo sapiens_hsa045120.24705164
134Focal adhesion_Homo sapiens_hsa045100.24688657
135Dorso-ventral axis formation_Homo sapiens_hsa043200.23934999
136Prion diseases_Homo sapiens_hsa050200.20593869
137Amoebiasis_Homo sapiens_hsa051460.19020753
138Platelet activation_Homo sapiens_hsa046110.18670306
139Endometrial cancer_Homo sapiens_hsa052130.18611709
140Colorectal cancer_Homo sapiens_hsa052100.18596005
141Salmonella infection_Homo sapiens_hsa051320.17460723
142Shigellosis_Homo sapiens_hsa051310.16590738
143Renal cell carcinoma_Homo sapiens_hsa052110.16183446

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »