BDP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is a subunit of the TFIIIB transcription initiation complex, which recruits RNA polymerase III to target promoters in order to initiate transcription. The encoded protein localizes to concentrated aggregates in the nucleus, and is required for transcription from all three types of polymerase III promoters. It is phosphorylated by casein kinase II during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K4 trimethylation (GO:0080182)6.19408083
2nuclear pore complex assembly (GO:0051292)6.14581550
3nuclear pore organization (GO:0006999)5.54592482
4mitotic sister chromatid cohesion (GO:0007064)5.30059884
5pore complex assembly (GO:0046931)4.81224124
6peptidyl-lysine trimethylation (GO:0018023)4.23451217
7regulation of DNA endoreduplication (GO:0032875)4.08739749
8regulation of RNA export from nucleus (GO:0046831)3.88207861
9positive regulation of histone H3-K4 methylation (GO:0051571)3.84975713
10histone H3-K4 methylation (GO:0051568)3.73858299
11histone mRNA catabolic process (GO:0071044)3.71998922
12regulation of helicase activity (GO:0051095)3.70070770
13centriole replication (GO:0007099)3.66959361
14dosage compensation (GO:0007549)3.62167787
15kinetochore organization (GO:0051383)3.61754519
16establishment of protein localization to Golgi (GO:0072600)3.54347813
17regulation of establishment of cell polarity (GO:2000114)3.52438436
18cytoplasmic mRNA processing body assembly (GO:0033962)3.47597507
19regulation of interleukin-12 biosynthetic process (GO:0045075)3.45809786
20microtubule anchoring (GO:0034453)3.44709120
21pre-miRNA processing (GO:0031054)3.43660335
22regulation of centrosome duplication (GO:0010824)3.42569851
23regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.41198242
24negative regulation of DNA-dependent DNA replication (GO:2000104)3.40087514
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.39752945
26regulation of histone H3-K9 methylation (GO:0051570)3.38117843
27mitotic chromosome condensation (GO:0007076)3.36768151
28interkinetic nuclear migration (GO:0022027)3.36253564
29regulation of nucleobase-containing compound transport (GO:0032239)3.33794526
30regulation of pigment cell differentiation (GO:0050932)3.31973109
31negative regulation of histone methylation (GO:0031061)3.26487090
32histone H3-K9 methylation (GO:0051567)3.26167530
33positive regulation of T cell cytokine production (GO:0002726)3.24575956
34replication fork processing (GO:0031297)3.24392551
35peptidyl-lysine methylation (GO:0018022)3.23491808
36neural tube formation (GO:0001841)3.19026178
37negative regulation of necroptotic process (GO:0060546)3.16587144
38I-kappaB phosphorylation (GO:0007252)3.14602666
39snRNA transcription (GO:0009301)3.14360316
40DNA topological change (GO:0006265)3.13387346
41positive regulation of developmental pigmentation (GO:0048087)3.12978721
42regulation of gamma-delta T cell differentiation (GO:0045586)3.12484429
43protein localization to kinetochore (GO:0034501)3.12196178
44regulation of centrosome cycle (GO:0046605)3.09501517
45negative regulation of thymocyte apoptotic process (GO:0070244)3.08461511
46sister chromatid cohesion (GO:0007062)3.06491358
47monoubiquitinated protein deubiquitination (GO:0035520)3.06283375
48regulation of necroptotic process (GO:0060544)3.04632645
49regulation of histone H3-K4 methylation (GO:0051569)3.03041903
50regulation of gamma-delta T cell activation (GO:0046643)3.02235703
51protein targeting to Golgi (GO:0000042)2.99859812
52DNA duplex unwinding (GO:0032508)2.99316017
53DNA geometric change (GO:0032392)2.98449095
54positive regulation of histone methylation (GO:0031062)2.95227682
55sister chromatid segregation (GO:0000819)2.93619552
56meiotic chromosome segregation (GO:0045132)2.89801705
57protein K11-linked deubiquitination (GO:0035871)2.89759756
58NLS-bearing protein import into nucleus (GO:0006607)2.87975208
59regulation of histone methylation (GO:0031060)2.87886784
60regulation of translational termination (GO:0006449)2.87787260
61regulation of establishment or maintenance of cell polarity (GO:0032878)2.87226665
62positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.86332679
63positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.86332679
64positive regulation of mitotic sister chromatid separation (GO:1901970)2.86332679
65retrograde transport, vesicle recycling within Golgi (GO:0000301)2.86102575
66regulation of mitotic spindle organization (GO:0060236)2.86089684
67microtubule organizing center organization (GO:0031023)2.86045771
68phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.85533485
69histone H3-K9 modification (GO:0061647)2.84956212
70maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.84904223
71mitotic nuclear envelope disassembly (GO:0007077)2.84630428
72regulation of telomere maintenance (GO:0032204)2.84178285
73chromatin remodeling at centromere (GO:0031055)2.83998979
74alternative mRNA splicing, via spliceosome (GO:0000380)2.83145711
75centrosome organization (GO:0051297)2.77151466
76regulation of spindle organization (GO:0090224)2.75535328
77kinetochore assembly (GO:0051382)2.74514094
78protein K48-linked deubiquitination (GO:0071108)2.74280695
79centrosome duplication (GO:0051298)2.74000288
80histone lysine methylation (GO:0034968)2.72050812
81negative regulation of translation, ncRNA-mediated (GO:0040033)2.70374123
82regulation of translation, ncRNA-mediated (GO:0045974)2.70374123
83negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.70374123
84positive regulation of mRNA processing (GO:0050685)2.67833973
85regulation of mitotic spindle checkpoint (GO:1903504)2.67592541
86regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.67592541
87membrane disassembly (GO:0030397)2.66544358
88nuclear envelope disassembly (GO:0051081)2.66544358
89protein localization to chromosome, centromeric region (GO:0071459)2.66490630
90protein localization to chromosome (GO:0034502)2.66009511
91double-strand break repair via homologous recombination (GO:0000724)2.65870632
92mitotic metaphase plate congression (GO:0007080)2.64220929
93CENP-A containing nucleosome assembly (GO:0034080)2.63629348
94positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.63456481
95regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.63456481
96recombinational repair (GO:0000725)2.61112223
97cell fate commitment involved in formation of primary germ layer (GO:0060795)2.60521759
98metaphase plate congression (GO:0051310)2.59199540
99embryonic retina morphogenesis in camera-type eye (GO:0060059)2.59155034
100negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.58257376
101histone H3-K36 demethylation (GO:0070544)2.57001876
102regulation of centriole replication (GO:0046599)2.56291937
103olfactory bulb development (GO:0021772)2.56035052
104microtubule nucleation (GO:0007020)2.55979755
105nucleus localization (GO:0051647)2.54396618
106chromatin assembly (GO:0031497)2.54043105
107positive regulation of mRNA 3-end processing (GO:0031442)2.53607650
108regulation of thymocyte apoptotic process (GO:0070243)2.53532478
109DNA unwinding involved in DNA replication (GO:0006268)2.53288347
110negative regulation of neurotransmitter secretion (GO:0046929)2.53242098
111regulation of mRNA 3-end processing (GO:0031440)2.53135090
112DNA replication-independent nucleosome assembly (GO:0006336)2.52688529
113DNA replication-independent nucleosome organization (GO:0034724)2.52688529
114chromatin assembly or disassembly (GO:0006333)2.52467785
115non-recombinational repair (GO:0000726)2.52355250
116double-strand break repair via nonhomologous end joining (GO:0006303)2.52355250
117DNA conformation change (GO:0071103)2.51958668
118positive regulation of cell cycle checkpoint (GO:1901978)2.51193519
119positive regulation of gamma-delta T cell activation (GO:0046645)2.51023140
120heterochromatin organization (GO:0070828)2.49750304
121CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.49588419
122T-helper cell differentiation (GO:0042093)2.49588419
123RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.49491582
124genitalia morphogenesis (GO:0035112)2.48728462
125positive regulation of dendritic spine morphogenesis (GO:0061003)2.48721984
126protein localization to synapse (GO:0035418)2.47905518
127rRNA catabolic process (GO:0016075)2.46956797
128regulation of protein polyubiquitination (GO:1902914)2.46776704
129mitotic sister chromatid segregation (GO:0000070)2.46319871
130prenylation (GO:0097354)2.45985335
131protein prenylation (GO:0018342)2.45985335
132attachment of spindle microtubules to kinetochore (GO:0008608)2.44974634
133IMP biosynthetic process (GO:0006188)2.44952605
134positive regulation of mRNA metabolic process (GO:1903313)2.44622819
135regulation of nuclear cell cycle DNA replication (GO:0033262)2.41622269
136DNA double-strand break processing (GO:0000729)2.41325469
137corticosteroid receptor signaling pathway (GO:0031958)2.41276555
138negative regulation of DNA recombination (GO:0045910)2.41273920
139RNA stabilization (GO:0043489)2.39035378
140mRNA stabilization (GO:0048255)2.39035378
141negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.37655688
142ncRNA catabolic process (GO:0034661)2.37469744
143histone-serine phosphorylation (GO:0035404)2.37352052
144positive regulation of chromosome segregation (GO:0051984)2.36891511
145regulation of T cell cytokine production (GO:0002724)2.36660993
146histone lysine demethylation (GO:0070076)2.35981817
147protein localization to Golgi apparatus (GO:0034067)2.35760613
148translesion synthesis (GO:0019985)2.35651372
149resolution of meiotic recombination intermediates (GO:0000712)2.35462877
150histone H3-K9 demethylation (GO:0033169)2.35251765
151reciprocal DNA recombination (GO:0035825)2.34113239
152reciprocal meiotic recombination (GO:0007131)2.34113239
153mRNA splice site selection (GO:0006376)2.34093597
154epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.34006899
155glucocorticoid receptor signaling pathway (GO:0042921)2.33662952
156telomere maintenance via telomerase (GO:0007004)2.33579518
157negative regulation of DNA repair (GO:0045738)2.32712747
158negative regulation of histone modification (GO:0031057)2.31614342
159DNA replication checkpoint (GO:0000076)2.31511297
160histone demethylation (GO:0016577)2.31379556
161establishment of chromosome localization (GO:0051303)2.31349933

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.92360757
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.41784537
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.03005201
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.86709001
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.80421209
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.42317941
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.18854097
8GBX2_23144817_ChIP-Seq_PC3_Human2.87607294
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.86832395
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.83109254
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.72019122
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48693504
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.43620699
14TAF15_26573619_Chip-Seq_HEK293_Human2.42375152
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.41952564
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.41331328
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.37281065
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.34168041
19TP63_19390658_ChIP-ChIP_HaCaT_Human2.28970458
20E2F1_21310950_ChIP-Seq_MCF-7_Human2.25287880
21IGF1R_20145208_ChIP-Seq_DFB_Human2.21592594
22VDR_22108803_ChIP-Seq_LS180_Human2.15218699
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.13668376
24RBPJ_22232070_ChIP-Seq_NCS_Mouse2.10105235
25E2F7_22180533_ChIP-Seq_HELA_Human10.0969537
26ZNF274_21170338_ChIP-Seq_K562_Hela1.93963550
27P300_19829295_ChIP-Seq_ESCs_Human1.90596953
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85524863
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.82081250
30MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.79673352
31SMAD4_21799915_ChIP-Seq_A2780_Human1.79000254
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77751347
33EZH2_22144423_ChIP-Seq_EOC_Human1.77328053
34STAT3_23295773_ChIP-Seq_U87_Human1.74425119
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.74193624
36MYC_22102868_ChIP-Seq_BL_Human1.73309498
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70815533
38AR_21909140_ChIP-Seq_LNCAP_Human1.69100095
39AR_21572438_ChIP-Seq_LNCaP_Human1.66733668
40ER_23166858_ChIP-Seq_MCF-7_Human1.66090019
41TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.62139434
42ELK1_19687146_ChIP-ChIP_HELA_Human1.58580113
43IRF8_22096565_ChIP-ChIP_GC-B_Human1.58422430
44TCF4_23295773_ChIP-Seq_U87_Human1.58271004
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57950446
46HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.56931556
47FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.56051299
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53598689
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.53090759
50RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50441497
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49797245
52IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.49174116
53GATA1_22025678_ChIP-Seq_K562_Human1.48514572
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.44608078
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43049264
56CBP_20019798_ChIP-Seq_JUKART_Human1.43049264
57* TP53_16413492_ChIP-PET_HCT116_Human1.43026239
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40491039
59MYB_26560356_Chip-Seq_TH1_Human1.40385629
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.40147207
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39213812
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39213812
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38073617
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37799484
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.35667261
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.35183212
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34076743
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34063872
69RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.34029753
70FOXM1_26456572_ChIP-Seq_MCF-7_Human1.33749006
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.33339255
72MYC_18555785_ChIP-Seq_MESCs_Mouse1.31903138
73MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30100229
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29918890
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29360259
76AR_25329375_ChIP-Seq_VCAP_Human1.29106082
77SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.28460910
78MYB_26560356_Chip-Seq_TH2_Human1.27861625
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.27835804
80MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.26706564
81PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24595910
82FLI1_21867929_ChIP-Seq_TH2_Mouse1.24588586
83CBX2_27304074_Chip-Seq_ESCs_Mouse1.24373043
84POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24254171
85SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24099931
86RUNX_20019798_ChIP-Seq_JUKART_Human1.22967088
87BCAT_22108803_ChIP-Seq_LS180_Human1.22177147
88PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21740165
89CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21633882
90EWS_26573619_Chip-Seq_HEK293_Human1.21426493
91NELFA_20434984_ChIP-Seq_ESCs_Mouse1.21185812
92MYB_21317192_ChIP-Seq_ERMYB_Mouse1.20960532
93E2F1_18555785_Chip-Seq_ESCs_Mouse1.20677947
94TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.20579183
95PKCTHETA_26484144_Chip-Seq_BREAST_Human1.19423659
96CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.18659593
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17414850
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17218367
99SOX9_26525672_Chip-Seq_HEART_Mouse1.17206550
100FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.16854727
101TCF4_18268006_ChIP-ChIP_LS174T_Human1.16604426
102SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16184393
103STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.15692348
104CIITA_25753668_ChIP-Seq_RAJI_Human1.15451262
105RNF2_27304074_Chip-Seq_NSC_Mouse1.15135362
106RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14633652
107SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14428531
108BRD4_25478319_ChIP-Seq_HGPS_Human1.14049068
109IRF8_21731497_ChIP-ChIP_J774_Mouse1.12844740
110SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12752607
111FUS_26573619_Chip-Seq_HEK293_Human1.11683661
112P53_22387025_ChIP-Seq_ESCs_Mouse1.09971896
113NFE2_27457419_Chip-Seq_LIVER_Mouse1.08700745
114TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08682261
115TCF4_22108803_ChIP-Seq_LS180_Human1.07748955
116MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07303754
117RUNX2_22187159_ChIP-Seq_PCA_Human1.06864061
118NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06308084
119SOX2_21211035_ChIP-Seq_LN229_Gbm1.06145294
120CMYC_18555785_Chip-Seq_ESCs_Mouse1.05387300
121STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05294435
122FLI1_27457419_Chip-Seq_LIVER_Mouse1.05256605
123IRF8_27001747_Chip-Seq_BMDM_Mouse1.05216091
124CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03663072
125BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03329166
126SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.02665724
127MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02501784
128SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01188757
129KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00180547
130TCF7_22412390_ChIP-Seq_EML_Mouse0.99788080
131PRDM14_20953172_ChIP-Seq_ESCs_Human0.99488706
132* JUN_21703547_ChIP-Seq_K562_Human0.99483800
133BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99370634
134KDM5A_27292631_Chip-Seq_BREAST_Human0.98781471
135* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97785360
136YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96805241
137PU_27001747_Chip-Seq_BMDM_Mouse0.92190289
138* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.92180384
139FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92013730
140FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91755332
141* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91541810
142HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91228576
143BP1_19119308_ChIP-ChIP_Hs578T_Human0.91128176
144MYCN_18555785_ChIP-Seq_MESCs_Mouse0.91119464
145TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90429118
146* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.89553662
147SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.89484407
148SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.89484407
149Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.88724361
150SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.88279076
151VDR_23849224_ChIP-Seq_CD4+_Human0.88190536
152SPI1_23547873_ChIP-Seq_NB4_Human0.87191671
153MYC_19079543_ChIP-ChIP_MESCs_Mouse0.87030389
154MAF_26560356_Chip-Seq_TH1_Human0.85563937
155GATA3_27048872_Chip-Seq_THYMUS_Human0.84147010
156KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.83654138
157SCL_19346495_ChIP-Seq_HPC-7_Human0.82576711
158FOXO3_23340844_ChIP-Seq_DLD1_Human0.82247047
159SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82086271
160ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.80145171
161RUNX1_22412390_ChIP-Seq_EML_Mouse0.80103544
162CTNNB1_20460455_ChIP-Seq_HCT116_Human0.79368710
163PCGF2_27294783_Chip-Seq_ESCs_Mouse0.79174183
164FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.78460192
165FOXP3_21729870_ChIP-Seq_TREG_Human0.78043356
166UTX_26944678_Chip-Seq_JUKART_Human0.76432117
167VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.75993143
168* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.75471400
169PCGF2_27294783_Chip-Seq_NPCs_Mouse0.74217467
170TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.72187485

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.16454726
2MP0003300_gastrointestinal_ulcer3.56439476
3MP0002009_preneoplasia2.98456115
4MP0000569_abnormal_digit_pigmentation2.95313966
5MP0010094_abnormal_chromosome_stability2.86602597
6MP0002396_abnormal_hematopoietic_system2.72705779
7MP0003787_abnormal_imprinting2.70751027
8MP0010352_gastrointestinal_tract_polyps2.63667262
9MP0003111_abnormal_nucleus_morphology2.61523452
10MP0002166_altered_tumor_susceptibility2.60813539
11MP0003077_abnormal_cell_cycle2.56913718
12MP0003693_abnormal_embryo_hatching2.55196027
13MP0002006_tumorigenesis2.53303183
14MP0010307_abnormal_tumor_latency2.32458451
15MP0008877_abnormal_DNA_methylation2.29258089
16MP0004957_abnormal_blastocyst_morpholog2.24337455
17MP0005076_abnormal_cell_differentiation2.16075475
18MP0003763_abnormal_thymus_physiology2.09717545
19MP0004808_abnormal_hematopoietic_stem2.00377549
20MP0008007_abnormal_cellular_replicative1.91372626
21MP0003121_genomic_imprinting1.91129012
22MP0008058_abnormal_DNA_repair1.87189171
23MP0003123_paternal_imprinting1.76698838
24MP0003566_abnormal_cell_adhesion1.75383803
25MP0005187_abnormal_penis_morphology1.70672481
26MP0000350_abnormal_cell_proliferation1.69571187
27MP0000427_abnormal_hair_cycle1.63241489
28MP0001835_abnormal_antigen_presentation1.62883145
29MP0001800_abnormal_humoral_immune1.62174396
30MP0006072_abnormal_retinal_apoptosis1.58536875
31MP0000778_abnormal_nervous_system1.55083586
32MP0009697_abnormal_copulation1.54972583
33MP0004264_abnormal_extraembryonic_tissu1.53861631
34MP0003866_abnormal_defecation1.53422294
35MP0010155_abnormal_intestine_physiology1.47518344
36MP0000490_abnormal_crypts_of1.46606328
37MP0005387_immune_system_phenotype1.45490392
38MP0001790_abnormal_immune_system1.45490392
39MP0002163_abnormal_gland_morphology1.44043851
40MP0002086_abnormal_extraembryonic_tissu1.43470540
41MP0002398_abnormal_bone_marrow1.42998302
42MP0006292_abnormal_olfactory_placode1.42590012
43MP0005174_abnormal_tail_pigmentation1.42582010
44MP0002928_abnormal_bile_duct1.41487597
45MP0001486_abnormal_startle_reflex1.40951191
46MP0005671_abnormal_response_to1.40016159
47MP0002102_abnormal_ear_morphology1.39628741
48MP0001672_abnormal_embryogenesis/_devel1.38897718
49MP0005380_embryogenesis_phenotype1.38897718
50MP0003984_embryonic_growth_retardation1.38563445
51MP0003436_decreased_susceptibility_to1.36259427
52MP0002088_abnormal_embryonic_growth/wei1.35789831
53MP0000703_abnormal_thymus_morphology1.34044019
54MP0001730_embryonic_growth_arrest1.32335325
55MP0003045_fibrosis1.31635600
56MP0003567_abnormal_fetal_cardiomyocyte1.28780779
57MP0005551_abnormal_eye_electrophysiolog1.28451121
58MP0002877_abnormal_melanocyte_morpholog1.26794514
59MP0002452_abnormal_antigen_presenting1.26612392
60MP0008961_abnormal_basal_metabolism1.25214989
61MP0009046_muscle_twitch1.22985673
62MP0003890_abnormal_embryonic-extraembry1.22082063
63MP0004197_abnormal_fetal_growth/weight/1.21309510
64MP0008995_early_reproductive_senescence1.21027102
65MP0004142_abnormal_muscle_tone1.18595747
66MP0003303_peritoneal_inflammation1.18217949
67MP0005397_hematopoietic_system_phenotyp1.18051879
68MP0001545_abnormal_hematopoietic_system1.18051879
69MP0003195_calcinosis1.16455339
70MP0002420_abnormal_adaptive_immunity1.15946322
71MP0001819_abnormal_immune_cell1.15011395
72MP0002938_white_spotting1.13217061
73MP0002723_abnormal_immune_serum1.11601193
74MP0005386_behavior/neurological_phenoty1.10803407
75MP0004924_abnormal_behavior1.10803407
76MP0004742_abnormal_vestibular_system1.10006351
77MP0002184_abnormal_innervation1.09720401
78MP0009703_decreased_birth_body1.09286863
79MP0001697_abnormal_embryo_size1.08344412
80MP0000716_abnormal_immune_system1.08079780
81MP0001188_hyperpigmentation1.06152421
82MP0002722_abnormal_immune_system1.05585195
83MP0003828_pulmonary_edema1.04685707
84MP0001286_abnormal_eye_development1.03878076
85MP0000689_abnormal_spleen_morphology1.03508069
86MP0003937_abnormal_limbs/digits/tail_de1.03410136
87MP0005253_abnormal_eye_physiology1.03075612
88MP0002095_abnormal_skin_pigmentation1.03024319
89MP0002234_abnormal_pharynx_morphology1.02450223
90MP0002084_abnormal_developmental_patter1.02154037
91MP0000631_abnormal_neuroendocrine_gland1.01407314
92MP0003136_yellow_coat_color1.01305754
93MP0002822_catalepsy1.00970437
94MP0001984_abnormal_olfaction0.99984215
95MP0005000_abnormal_immune_tolerance0.99562056
96MP0009780_abnormal_chondrocyte_physiolo0.99522054
97MP0000383_abnormal_hair_follicle0.98849902
98MP0002085_abnormal_embryonic_tissue0.98756920
99MP0003705_abnormal_hypodermis_morpholog0.98373776
100MP0005646_abnormal_pituitary_gland0.98037172
101MP0000647_abnormal_sebaceous_gland0.97889080
102MP0003880_abnormal_central_pattern0.97832622
103MP0002019_abnormal_tumor_incidence0.97339501
104MP0002751_abnormal_autonomic_nervous0.95509672
105MP0005379_endocrine/exocrine_gland_phen0.95250019
106MP0002405_respiratory_system_inflammati0.94928570
107MP0000955_abnormal_spinal_cord0.94572396
108MP0002735_abnormal_chemical_nociception0.93595664
109MP0002429_abnormal_blood_cell0.91778978
110MP0002160_abnormal_reproductive_system0.90199435
111MP0000015_abnormal_ear_pigmentation0.89879275
112MP0002233_abnormal_nose_morphology0.89650829
113MP0002557_abnormal_social/conspecific_i0.89404908
114MP0000313_abnormal_cell_death0.89009021
115MP0000432_abnormal_head_morphology0.88640155
116MP0001968_abnormal_touch/_nociception0.88404418
117MP0009278_abnormal_bone_marrow0.87216627
118MP0003861_abnormal_nervous_system0.86988136
119MP0000477_abnormal_intestine_morphology0.86112543
120MP0001915_intracranial_hemorrhage0.85411174
121MP0002925_abnormal_cardiovascular_devel0.85230266
122MP0010678_abnormal_skin_adnexa0.84655998
123MP0003935_abnormal_craniofacial_develop0.84406570
124MP0002080_prenatal_lethality0.84309073
125MP0001929_abnormal_gametogenesis0.83959269
126MP0009745_abnormal_behavioral_response0.83381163
127MP0002067_abnormal_sensory_capabilities0.83351840
128MP0001873_stomach_inflammation0.83116171
129MP0002638_abnormal_pupillary_reflex0.82791295
130MP0003868_abnormal_feces_composition0.82603401
131MP0002697_abnormal_eye_size0.82382396
132MP0005025_abnormal_response_to0.82255352
133MP0003183_abnormal_peptide_metabolism0.81806274
134MP0003448_altered_tumor_morphology0.81215553
135MP0000733_abnormal_muscle_development0.81058720
136MP0002109_abnormal_limb_morphology0.80785603
137MP0003385_abnormal_body_wall0.80415875
138MP0003453_abnormal_keratinocyte_physiol0.80035412
139MP0003755_abnormal_palate_morphology0.78970222
140MP0002210_abnormal_sex_determination0.78767645
141MP0005391_vision/eye_phenotype0.78369971
142MP0002272_abnormal_nervous_system0.78302413
143MP0008932_abnormal_embryonic_tissue0.78277742
144MP0004134_abnormal_chest_morphology0.78111046
145MP0006276_abnormal_autonomic_nervous0.77371441
146MP0010630_abnormal_cardiac_muscle0.76898123
147MP0003718_maternal_effect0.76876688
148MP0004947_skin_inflammation0.76783947
149MP0001299_abnormal_eye_distance/0.75956732
150MP0009785_altered_susceptibility_to0.75672858
151MP0009672_abnormal_birth_weight0.75489172
152MP0000767_abnormal_smooth_muscle0.75307327
153MP0001293_anophthalmia0.75265464
154MP0003943_abnormal_hepatobiliary_system0.75152446
155MP0000371_diluted_coat_color0.74835623
156MP0003698_abnormal_male_reproductive0.74644531
157MP0000627_abnormal_mammary_gland0.74351149
158MP0002063_abnormal_learning/memory/cond0.74161586
159MP0005621_abnormal_cell_physiology0.74118246
160MP0003786_premature_aging0.73997570
161MP0000428_abnormal_craniofacial_morphol0.73054857
162MP0010234_abnormal_vibrissa_follicle0.72959335
163MP0003941_abnormal_skin_development0.72737886
164MP0003635_abnormal_synaptic_transmissio0.71951553
165MP0005310_abnormal_salivary_gland0.69423811
166MP0000516_abnormal_urinary_system0.67419611

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)6.32855399
2Abnormality of the fingertips (HP:0001211)4.05050554
3Chromsome breakage (HP:0040012)3.69753576
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.15208774
5Protruding tongue (HP:0010808)3.03278881
6Oligodactyly (hands) (HP:0001180)3.00996972
7Deviation of the thumb (HP:0009603)2.99866501
8Long eyelashes (HP:0000527)2.97191157
9Proximal placement of thumb (HP:0009623)2.96790909
10Acute myeloid leukemia (HP:0004808)2.95530022
11Ectopic kidney (HP:0000086)2.82537525
12Truncal obesity (HP:0001956)2.78991786
13Prominent nose (HP:0000448)2.77867248
14Abnormality of chromosome stability (HP:0003220)2.73325761
15Hyperventilation (HP:0002883)2.69468157
16Genetic anticipation (HP:0003743)2.67029168
17Gaze-evoked nystagmus (HP:0000640)2.63552037
18Abnormality of the nasal septum (HP:0000419)2.62643468
19Increased nuchal translucency (HP:0010880)2.62423479
20Lip pit (HP:0100267)2.58033754
21Drooling (HP:0002307)2.55783827
22Absent frontal sinuses (HP:0002688)2.55511555
23Blepharitis (HP:0000498)2.52787632
24Urethral obstruction (HP:0000796)2.48203820
25Pancreatic fibrosis (HP:0100732)2.44370232
26Pancreatic cysts (HP:0001737)2.40708375
27Cutis marmorata (HP:0000965)2.39653025
28Abnormality of the renal cortex (HP:0011035)2.39283259
29Fair hair (HP:0002286)2.39261506
30Low anterior hairline (HP:0000294)2.34246055
31Recurrent viral infections (HP:0004429)2.33267013
32Chronic hepatic failure (HP:0100626)2.31942277
33Abnormality of midbrain morphology (HP:0002418)2.30378790
34Molar tooth sign on MRI (HP:0002419)2.30378790
35Aplasia/Hypoplasia of the tibia (HP:0005772)2.29966147
36T lymphocytopenia (HP:0005403)2.29495607
37Poor coordination (HP:0002370)2.29362234
38Febrile seizures (HP:0002373)2.28289976
39Broad-based gait (HP:0002136)2.26255181
40Excessive salivation (HP:0003781)2.25674509
41Subacute progressive viral hepatitis (HP:0006572)2.21812876
42Nephronophthisis (HP:0000090)2.20071357
43Macroorchidism (HP:0000053)2.19463850
44Deep philtrum (HP:0002002)2.19429692
45Papillary thyroid carcinoma (HP:0002895)2.16010726
46Abnormality of the renal medulla (HP:0100957)2.15839997
47Midline defect of the nose (HP:0004122)2.15771612
48Hypoplastic labia majora (HP:0000059)2.15416545
49Renal cortical cysts (HP:0000803)2.14356443
50Prostate neoplasm (HP:0100787)2.14319899
51Abnormality of T cell number (HP:0011839)2.13546676
52Myelodysplasia (HP:0002863)2.13516077
53Intestinal atresia (HP:0011100)2.10426531
54Sloping forehead (HP:0000340)2.10295321
55Progressive cerebellar ataxia (HP:0002073)2.10102820
56Hepatoblastoma (HP:0002884)2.08822346
57Medulloblastoma (HP:0002885)2.08505607
58Obsessive-compulsive behavior (HP:0000722)2.07803023
59Recurrent fungal infections (HP:0002841)2.06958687
60Neoplasm of striated muscle (HP:0009728)2.06659060
61Submucous cleft hard palate (HP:0000176)2.06163097
62Impulsivity (HP:0100710)2.06143356
63Short 4th metacarpal (HP:0010044)2.05072097
64Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.05072097
65Medial flaring of the eyebrow (HP:0010747)2.03920378
66Oligodactyly (HP:0012165)2.03771978
67Supernumerary ribs (HP:0005815)2.03407544
68Smooth philtrum (HP:0000319)2.03388989
69Syringomyelia (HP:0003396)2.03348215
70Spinal cord lesions (HP:0100561)2.03348215
71Abnormal pancreas size (HP:0012094)2.02478526
72Birth length less than 3rd percentile (HP:0003561)2.00831688
73Hematochezia (HP:0002573)1.99311594
74Abnormality of the labia majora (HP:0012881)1.99124434
75Highly arched eyebrow (HP:0002553)1.96013756
76Aplasia/Hypoplasia of the sternum (HP:0006714)1.95934018
77Aplasia/Hypoplasia of the uvula (HP:0010293)1.95280988
78Narrow palate (HP:0000189)1.94874943
79Limited elbow extension (HP:0001377)1.92926011
80Diastasis recti (HP:0001540)1.91417645
81Short chin (HP:0000331)1.90775855
82Amaurosis fugax (HP:0100576)1.90269036
83Gait imbalance (HP:0002141)1.87506370
84Glioma (HP:0009733)1.85966380
85Meckel diverticulum (HP:0002245)1.85879668
86Genital tract atresia (HP:0001827)1.84923919
87Abnormality of the ischium (HP:0003174)1.84869137
88Sandal gap (HP:0001852)1.84544364
89Abnormality of the columella (HP:0009929)1.84335535
90Abnormality of the labia minora (HP:0012880)1.83447910
91True hermaphroditism (HP:0010459)1.83231358
92Abnormality of the preputium (HP:0100587)1.83183944
93Widely spaced teeth (HP:0000687)1.82680104
94Aqueductal stenosis (HP:0002410)1.81019391
95Abnormality of chromosome segregation (HP:0002916)1.80596459
96Nephroblastoma (Wilms tumor) (HP:0002667)1.80493440
97Lymphoma (HP:0002665)1.80488461
98Abnormality of homocysteine metabolism (HP:0010919)1.80317146
99Homocystinuria (HP:0002156)1.80317146
100Biliary tract neoplasm (HP:0100574)1.80133125
101Labial hypoplasia (HP:0000066)1.78983371
102Congenital primary aphakia (HP:0007707)1.78762786
103Generalized hypopigmentation of hair (HP:0011358)1.78662944
104Thyroid carcinoma (HP:0002890)1.78423999
105Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.78125072
106IgA deficiency (HP:0002720)1.78061361
107Neoplasm of the adrenal cortex (HP:0100641)1.78016416
108Thick eyebrow (HP:0000574)1.77884362
109Thyroiditis (HP:0100646)1.77500845
110Gastrointestinal atresia (HP:0002589)1.77260463
111Neoplasm of the oral cavity (HP:0100649)1.76924015
112Malignant gastrointestinal tract tumors (HP:0006749)1.76720082
113Gastrointestinal carcinoma (HP:0002672)1.76720082
114Heterotopia (HP:0002282)1.76549809
115Abnormality of the ileum (HP:0001549)1.76238958
116Exostoses (HP:0100777)1.75713689
117Clubbing of toes (HP:0100760)1.74919199
118Exotropia (HP:0000577)1.74562669
119Abnormality of the carotid arteries (HP:0005344)1.72499141
120Bifid tongue (HP:0010297)1.72452067
121Sparse lateral eyebrow (HP:0005338)1.71349420
122Anal stenosis (HP:0002025)1.71289391
123Absent radius (HP:0003974)1.70437606
124Abnormal number of incisors (HP:0011064)1.70046323
125Chronic mucocutaneous candidiasis (HP:0002728)1.69492680
126Recurrent cutaneous fungal infections (HP:0011370)1.69492680
127Supernumerary bones of the axial skeleton (HP:0009144)1.69300799
128Embryonal renal neoplasm (HP:0011794)1.69119566
129Cupped ear (HP:0000378)1.68542071
130Vaginal atresia (HP:0000148)1.68037652
131Periodontitis (HP:0000704)1.67780724
132Atonic seizures (HP:0010819)1.67161554
133Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.66958195
134Rhabdomyosarcoma (HP:0002859)1.66854434
135Broad palm (HP:0001169)1.66673648
136Focal seizures (HP:0007359)1.65813745
137Neonatal hypoglycemia (HP:0001998)1.65451085
138Abnormality of the pubic bones (HP:0003172)1.65344089
139Chronic diarrhea (HP:0002028)1.65299961
140Tubulointerstitial nephritis (HP:0001970)1.65207483
141Acute lymphatic leukemia (HP:0006721)1.65155765
142Cafe-au-lait spot (HP:0000957)1.65124320
143Transitional cell carcinoma of the bladder (HP:0006740)1.64834951
144Hip dysplasia (HP:0001385)1.64826187
145Postaxial foot polydactyly (HP:0001830)1.64464913
146Skull defect (HP:0001362)1.64026470
147Preaxial hand polydactyly (HP:0001177)1.63057791
148Dialeptic seizures (HP:0011146)1.62955325
149Abnormality of B cell number (HP:0010975)1.62048275
150B lymphocytopenia (HP:0010976)1.62048275
151Increased density of long bones (HP:0006392)1.61099574
152Synophrys (HP:0000664)1.61090204
153Abnormality of the frontal sinuses (HP:0002687)1.60305003
154High pitched voice (HP:0001620)1.59983271
155Dislocated radial head (HP:0003083)1.59434868
156Vertebral clefting (HP:0008428)1.59070255
157Astrocytoma (HP:0009592)1.57637614
158Abnormality of the astrocytes (HP:0100707)1.57637614
159Arterial thrombosis (HP:0004420)1.57552327
160Abnormality of the incisor (HP:0000676)1.57482092
161Intestinal fistula (HP:0100819)1.57348309
162Small intestinal stenosis (HP:0012848)1.56931850
163Duodenal stenosis (HP:0100867)1.56931850

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NUAK15.08688635
2CDK124.33135585
3DMPK3.12127921
4CDC73.09808285
5AKT32.92132026
6ZAK2.58093438
7CASK2.50390906
8STK38L2.45929751
9MAP3K42.15364167
10PIK3CA2.15187650
11STK392.06998217
12BRD42.06268937
13BMPR1B2.05625509
14MST42.00767776
15TNIK1.94628416
16LATS11.80787878
17MAP3K71.80553922
18TXK1.75186551
19CAMK1D1.74156619
20JAK31.66192038
21MAP3K141.62802205
22MAPK131.53018815
23MAP4K11.52719483
24NEK21.50824945
25SRPK11.49553405
26RAF11.48496164
27ATR1.46355421
28STK31.42385118
29WNK31.41570352
30FRK1.39794800
31MKNK21.37334845
32CDK41.37160694
33CAMK1G1.32001425
34NTRK31.31891858
35CHUK1.30987776
36PLK31.30216632
37PAK31.25724838
38STK101.24937676
39TTK1.24610722
40CHEK21.21826349
41CHEK11.21393019
42SCYL21.18464840
43TYK21.18006052
44STK41.16949130
45EIF2AK31.16260991
46BRSK21.15353470
47TSSK61.14758370
48FGFR31.13546584
49ATM1.12769125
50WNK41.12652686
51CDK61.11741556
52MELK1.11049659
53AURKB1.10588734
54RPS6KA41.10165218
55PIM11.08028754
56WNK11.06975193
57JAK11.05981945
58MARK11.04194075
59MAP2K71.03359526
60NEK61.00696307
61MKNK11.00443495
62PLK10.97258456
63ALK0.94802949
64NLK0.94554611
65PLK20.93567268
66EPHA40.92734558
67PDGFRB0.91786870
68CDK30.90766873
69EIF2AK20.86400736
70MARK30.85294740
71PLK40.83417676
72CSNK1E0.82639491
73IKBKB0.80363344
74CAMKK20.78228075
75FGFR20.77376905
76MTOR0.77166606
77CDK20.76600031
78BCR0.75608796
79ITK0.74370782
80TAF10.74150822
81SGK10.71983191
82WEE10.71351911
83CLK10.71275564
84CDK90.69324690
85IRAK40.69160727
86PINK10.68273413
87RPS6KB10.66924201
88SGK4940.66798759
89SGK2230.66798759
90OXSR10.65388738
91CSK0.65327436
92BMPR20.65085526
93PRKDC0.63043562
94IKBKE0.62195494
95CDK10.61957590
96NEK10.61323788
97RPS6KA50.59510774
98RPS6KB20.58780337
99MAPK140.58641918
100TLK10.58579092
101KIT0.58508949
102PRKCQ0.58240757
103SGK30.56750432
104NTRK20.56242609
105STK240.55710296
106FGFR10.55215060
107SGK20.54819721
108GRK10.54087704
109CCNB10.53824042
110TRIM280.53490051
111CDK70.53039208
112HCK0.52446724
113MAP4K20.51501462
114KSR10.51049371
115MAP3K80.51006624
116TTN0.50442737
117PRKCE0.49890617
118PKN10.49397031
119PASK0.48890732
120CSNK1D0.48510316
121TAOK30.48495292
122INSRR0.48492064
123BTK0.48375587
124EPHA20.48209628
125MAP2K40.47201513
126PNCK0.46664623
127CSF1R0.46490021
128EIF2AK10.45832261
129LCK0.45668859
130RPS6KA30.45550425
131ERBB20.45045321
132PRKAA20.44184763
133MAPK100.44013965
134MAP3K100.43931355
135STK380.43385316
136PRKACB0.42659843
137DYRK1A0.42624664
138ACVR1B0.42602211
139GSK3B0.41803675
140ERBB30.41456567
141MAPK10.40199658
142PRKAA10.40136974
143AKT10.40125366
144TAOK10.39446137
145* TEC0.38473666
146TRPM70.37297929

Predicted pathways (KEGG)

RankGene SetZ-score
1NF-kappa B signaling pathway_Homo sapiens_hsa040642.33466765
2Mismatch repair_Homo sapiens_hsa034302.25725026
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.23193005
4Non-homologous end-joining_Homo sapiens_hsa034502.20804337
5Homologous recombination_Homo sapiens_hsa034402.10988772
6Cell cycle_Homo sapiens_hsa041102.08650825
7Intestinal immune network for IgA production_Homo sapiens_hsa046721.95970070
8DNA replication_Homo sapiens_hsa030301.94958999
9Nicotine addiction_Homo sapiens_hsa050331.89708757
10NOD-like receptor signaling pathway_Homo sapiens_hsa046211.87827363
11Adherens junction_Homo sapiens_hsa045201.83991271
12Fanconi anemia pathway_Homo sapiens_hsa034601.83406379
13Systemic lupus erythematosus_Homo sapiens_hsa053221.81950423
14Selenocompound metabolism_Homo sapiens_hsa004501.81152472
15RNA transport_Homo sapiens_hsa030131.80396190
16Leishmaniasis_Homo sapiens_hsa051401.71697870
17Circadian rhythm_Homo sapiens_hsa047101.68659135
18Herpes simplex infection_Homo sapiens_hsa051681.67982127
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.66312637
20Measles_Homo sapiens_hsa051621.63210438
21Taste transduction_Homo sapiens_hsa047421.58704936
22One carbon pool by folate_Homo sapiens_hsa006701.58453094
23Antigen processing and presentation_Homo sapiens_hsa046121.52827384
24mRNA surveillance pathway_Homo sapiens_hsa030151.51746475
25MicroRNAs in cancer_Homo sapiens_hsa052061.46978404
26Primary immunodeficiency_Homo sapiens_hsa053401.43753438
27RNA degradation_Homo sapiens_hsa030181.36666174
28p53 signaling pathway_Homo sapiens_hsa041151.35588203
29Transcriptional misregulation in cancer_Homo sapiens_hsa052021.35121073
30T cell receptor signaling pathway_Homo sapiens_hsa046601.34625057
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.33412130
32Spliceosome_Homo sapiens_hsa030401.32342293
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.31148776
34Viral carcinogenesis_Homo sapiens_hsa052031.30734442
35Osteoclast differentiation_Homo sapiens_hsa043801.27702126
36Hematopoietic cell lineage_Homo sapiens_hsa046401.27160116
37TNF signaling pathway_Homo sapiens_hsa046681.25137840
38Toxoplasmosis_Homo sapiens_hsa051451.24926187
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.23013314
40Small cell lung cancer_Homo sapiens_hsa052221.21398765
41Allograft rejection_Homo sapiens_hsa053301.21103120
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.19091456
43Base excision repair_Homo sapiens_hsa034101.18608616
44B cell receptor signaling pathway_Homo sapiens_hsa046621.18140021
45Phototransduction_Homo sapiens_hsa047441.18029387
46Oocyte meiosis_Homo sapiens_hsa041141.17806193
47Glutamatergic synapse_Homo sapiens_hsa047241.15954249
48Protein export_Homo sapiens_hsa030601.15831391
49HTLV-I infection_Homo sapiens_hsa051661.13710422
50Jak-STAT signaling pathway_Homo sapiens_hsa046301.13525918
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.12871381
52Viral myocarditis_Homo sapiens_hsa054161.12848094
53Hepatitis B_Homo sapiens_hsa051611.10499586
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08098933
55Graft-versus-host disease_Homo sapiens_hsa053321.06596960
56Epstein-Barr virus infection_Homo sapiens_hsa051691.06046061
57Chronic myeloid leukemia_Homo sapiens_hsa052201.05276797
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05066444
59Lysine degradation_Homo sapiens_hsa003101.05055660
60Long-term potentiation_Homo sapiens_hsa047201.05041463
61Dopaminergic synapse_Homo sapiens_hsa047281.04813590
62Influenza A_Homo sapiens_hsa051641.03105080
63Long-term depression_Homo sapiens_hsa047301.01204890
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.00629550
65Amphetamine addiction_Homo sapiens_hsa050311.00239616
66Insulin secretion_Homo sapiens_hsa049111.00045286
67Nucleotide excision repair_Homo sapiens_hsa034200.99600348
68Endometrial cancer_Homo sapiens_hsa052130.98394889
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96877046
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.95963868
71Basal transcription factors_Homo sapiens_hsa030220.95809572
72Circadian entrainment_Homo sapiens_hsa047130.94421467
73Propanoate metabolism_Homo sapiens_hsa006400.92784371
74Prostate cancer_Homo sapiens_hsa052150.92538169
75Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91943592
76Olfactory transduction_Homo sapiens_hsa047400.89274036
77Acute myeloid leukemia_Homo sapiens_hsa052210.88211493
78Type II diabetes mellitus_Homo sapiens_hsa049300.87167671
79Cholinergic synapse_Homo sapiens_hsa047250.86833235
80Fatty acid biosynthesis_Homo sapiens_hsa000610.86466759
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.85213521
82Type I diabetes mellitus_Homo sapiens_hsa049400.85116343
83Asthma_Homo sapiens_hsa053100.83526626
84Legionellosis_Homo sapiens_hsa051340.83273158
85Salivary secretion_Homo sapiens_hsa049700.83267040
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82252135
87Apoptosis_Homo sapiens_hsa042100.82234496
88Pancreatic cancer_Homo sapiens_hsa052120.82082002
89TGF-beta signaling pathway_Homo sapiens_hsa043500.81070038
90cAMP signaling pathway_Homo sapiens_hsa040240.80515620
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79297833
92Regulation of autophagy_Homo sapiens_hsa041400.78206530
93Calcium signaling pathway_Homo sapiens_hsa040200.78042524
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77886126
95mTOR signaling pathway_Homo sapiens_hsa041500.77588775
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77013212
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76280394
98Hedgehog signaling pathway_Homo sapiens_hsa043400.75772007
99Proteoglycans in cancer_Homo sapiens_hsa052050.75319876
100Morphine addiction_Homo sapiens_hsa050320.74517659
101Alcoholism_Homo sapiens_hsa050340.74243265
102Renin secretion_Homo sapiens_hsa049240.72798771
103ABC transporters_Homo sapiens_hsa020100.72791781
104Serotonergic synapse_Homo sapiens_hsa047260.72371347
105Tuberculosis_Homo sapiens_hsa051520.72091231
106FoxO signaling pathway_Homo sapiens_hsa040680.72085186
107Colorectal cancer_Homo sapiens_hsa052100.71196908
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71024336
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69609878
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69157005
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68112965
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.67821896
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67454849
114Glioma_Homo sapiens_hsa052140.66514624
115Autoimmune thyroid disease_Homo sapiens_hsa053200.66492473
116Axon guidance_Homo sapiens_hsa043600.65673481
117Oxytocin signaling pathway_Homo sapiens_hsa049210.65405104
118Pathways in cancer_Homo sapiens_hsa052000.64675088
119Chemokine signaling pathway_Homo sapiens_hsa040620.64335791
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64123616
121Dorso-ventral axis formation_Homo sapiens_hsa043200.64016871
122Cocaine addiction_Homo sapiens_hsa050300.63277205
123Choline metabolism in cancer_Homo sapiens_hsa052310.62680508
124Butanoate metabolism_Homo sapiens_hsa006500.62362727
125Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62027803
126ErbB signaling pathway_Homo sapiens_hsa040120.61373510
127Salmonella infection_Homo sapiens_hsa051320.60757121
128Platelet activation_Homo sapiens_hsa046110.60422432
129Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59993628
130AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59896876
131Thyroid hormone synthesis_Homo sapiens_hsa049180.59883367
132Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59771042
133Ether lipid metabolism_Homo sapiens_hsa005650.59172749
134Malaria_Homo sapiens_hsa051440.58871712
135MAPK signaling pathway_Homo sapiens_hsa040100.57465667
136GABAergic synapse_Homo sapiens_hsa047270.55563628
137African trypanosomiasis_Homo sapiens_hsa051430.54530927
138Melanoma_Homo sapiens_hsa052180.53787326
139Steroid biosynthesis_Homo sapiens_hsa001000.52746404
140Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52543642
141Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52252026
142Estrogen signaling pathway_Homo sapiens_hsa049150.51942537
143Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51345755
144Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50379529
145HIF-1 signaling pathway_Homo sapiens_hsa040660.50372595
146Wnt signaling pathway_Homo sapiens_hsa043100.50264683
147Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50149333
148Notch signaling pathway_Homo sapiens_hsa043300.50081102
149Non-small cell lung cancer_Homo sapiens_hsa052230.49994455
150Hippo signaling pathway_Homo sapiens_hsa043900.49330594
151Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48723423
152Basal cell carcinoma_Homo sapiens_hsa052170.48522734
153Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47456520
154Focal adhesion_Homo sapiens_hsa045100.47425858
155Glucagon signaling pathway_Homo sapiens_hsa049220.47377486
156RNA polymerase_Homo sapiens_hsa030200.47277785
157Hepatitis C_Homo sapiens_hsa051600.45966992
158Inositol phosphate metabolism_Homo sapiens_hsa005620.45950954
159Prolactin signaling pathway_Homo sapiens_hsa049170.45910879

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